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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD12-VAPA (FusionGDB2 ID:4584)

Fusion Gene Summary for ANKRD12-VAPA

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD12-VAPA
Fusion gene ID: 4584
HgeneTgene
Gene symbol

ANKRD12

VAPA

Gene ID

23253

9218

Gene nameankyrin repeat domain 12VAMP associated protein A
SynonymsANCO-2|ANCO1|GAC-1|Nbla00144VAP-33|VAP-A|VAP33|hVAP-33
Cytomap

18p11.22

18p11.22

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 12ankyrin repeat-containing cofactor 2vesicle-associated membrane protein-associated protein A33 kDa VAMP-associated proteinVAMP (vesicle-associated membrane protein)-associated protein A, 33kDaVAMP-Aepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc

Q6UB98

.
Ensembl transtripts involved in fusion geneENST00000540578, ENST00000262126, 
ENST00000383440, ENST00000400020, 
ENST00000340541, ENST00000400000, 
ENST00000584796, 
Fusion gene scores* DoF score17 X 12 X 9=183612 X 11 X 6=792
# samples 2114
** MAII scorelog2(21/1836*10)=-3.12810482574769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/792*10)=-2.50007360313464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD12 [Title/Abstract] AND VAPA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD12(9136963)-VAPA(9950392), # samples:1
ANKRD12(9221997)-VAPA(9931807), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVAPA

GO:0044791

positive regulation by host of viral release from host cell

19515777

TgeneVAPA

GO:0044828

negative regulation by host of viral genome replication

19515777

TgeneVAPA

GO:0044829

positive regulation by host of viral genome replication

19515777


check buttonFusion gene breakpoints across ANKRD12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VAPA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AANKRD12chr18

9221997

+VAPAchr18

9931807

+
ChimerDB4STADTCGA-CD-8530-01AANKRD12chr18

9136963

+VAPAchr18

9950392

+


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Fusion Gene ORF analysis for ANKRD12-VAPA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000540578ENST00000340541ANKRD12chr18

9221997

+VAPAchr18

9931807

+
3UTR-3CDSENST00000540578ENST00000340541ANKRD12chr18

9136963

+VAPAchr18

9950392

+
3UTR-3CDSENST00000540578ENST00000400000ANKRD12chr18

9221997

+VAPAchr18

9931807

+
3UTR-3CDSENST00000540578ENST00000400000ANKRD12chr18

9136963

+VAPAchr18

9950392

+
3UTR-3UTRENST00000540578ENST00000584796ANKRD12chr18

9221997

+VAPAchr18

9931807

+
3UTR-3UTRENST00000540578ENST00000584796ANKRD12chr18

9136963

+VAPAchr18

9950392

+
5CDS-3UTRENST00000262126ENST00000584796ANKRD12chr18

9221997

+VAPAchr18

9931807

+
5CDS-3UTRENST00000383440ENST00000584796ANKRD12chr18

9221997

+VAPAchr18

9931807

+
5CDS-3UTRENST00000400020ENST00000584796ANKRD12chr18

9221997

+VAPAchr18

9931807

+
5UTR-3CDSENST00000262126ENST00000340541ANKRD12chr18

9136963

+VAPAchr18

9950392

+
5UTR-3CDSENST00000262126ENST00000400000ANKRD12chr18

9136963

+VAPAchr18

9950392

+
5UTR-3CDSENST00000383440ENST00000340541ANKRD12chr18

9136963

+VAPAchr18

9950392

+
5UTR-3CDSENST00000383440ENST00000400000ANKRD12chr18

9136963

+VAPAchr18

9950392

+
5UTR-3UTRENST00000262126ENST00000584796ANKRD12chr18

9136963

+VAPAchr18

9950392

+
5UTR-3UTRENST00000383440ENST00000584796ANKRD12chr18

9136963

+VAPAchr18

9950392

+
In-frameENST00000262126ENST00000340541ANKRD12chr18

9221997

+VAPAchr18

9931807

+
In-frameENST00000262126ENST00000400000ANKRD12chr18

9221997

+VAPAchr18

9931807

+
In-frameENST00000383440ENST00000340541ANKRD12chr18

9221997

+VAPAchr18

9931807

+
In-frameENST00000383440ENST00000400000ANKRD12chr18

9221997

+VAPAchr18

9931807

+
In-frameENST00000400020ENST00000340541ANKRD12chr18

9221997

+VAPAchr18

9931807

+
In-frameENST00000400020ENST00000400000ANKRD12chr18

9221997

+VAPAchr18

9931807

+
intron-3CDSENST00000400020ENST00000340541ANKRD12chr18

9136963

+VAPAchr18

9950392

+
intron-3CDSENST00000400020ENST00000400000ANKRD12chr18

9136963

+VAPAchr18

9950392

+
intron-3UTRENST00000400020ENST00000584796ANKRD12chr18

9136963

+VAPAchr18

9950392

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000383440ANKRD12chr189221997+ENST00000400000VAPAchr189931807+761211312421801519
ENST00000383440ANKRD12chr189221997+ENST00000340541VAPAchr189931807+208411312421936564
ENST00000262126ANKRD12chr189221997+ENST00000400000VAPAchr189931807+766411832251853542
ENST00000262126ANKRD12chr189221997+ENST00000340541VAPAchr189931807+213611832251988587
ENST00000400020ANKRD12chr189221997+ENST00000400000VAPAchr189931807+771712363471906519
ENST00000400020ANKRD12chr189221997+ENST00000340541VAPAchr189931807+218912363472041564

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000383440ENST00000400000ANKRD12chr189221997+VAPAchr189931807+0.0001178610.9998821
ENST00000383440ENST00000340541ANKRD12chr189221997+VAPAchr189931807+0.0016142570.9983858
ENST00000262126ENST00000400000ANKRD12chr189221997+VAPAchr189931807+0.0001099920.99988997
ENST00000262126ENST00000340541ANKRD12chr189221997+VAPAchr189931807+0.0013712310.99862874
ENST00000400020ENST00000400000ANKRD12chr189221997+VAPAchr189931807+0.0001119510.99988806
ENST00000400020ENST00000340541ANKRD12chr189221997+VAPAchr189931807+0.0010055320.9989944

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Fusion Genomic Features for ANKRD12-VAPA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD12chr189221997+VAPAchr189931806+0.0001822880.9998178
ANKRD12chr189136963+VAPAchr189950391+3.04E-050.9999696
ANKRD12chr189221997+VAPAchr189931806+0.0001822880.9998178
ANKRD12chr189136963+VAPAchr189950391+3.04E-050.9999696

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD12-VAPA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:9136963/chr18:9950392)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD12

Q6UB98

.
FUNCTION: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD12chr18:9221997chr18:9931807ENST00000262126+813184_2133142063.0RepeatNote=ANK 1
HgeneANKRD12chr18:9221997chr18:9931807ENST00000262126+813217_2463142063.0RepeatNote=ANK 2
HgeneANKRD12chr18:9221997chr18:9931807ENST00000262126+813250_2803142063.0RepeatNote=ANK 3
HgeneANKRD12chr18:9221997chr18:9931807ENST00000383440+712184_2132912040.0RepeatNote=ANK 1
HgeneANKRD12chr18:9221997chr18:9931807ENST00000383440+712217_2462912040.0RepeatNote=ANK 2
HgeneANKRD12chr18:9221997chr18:9931807ENST00000383440+712250_2802912040.0RepeatNote=ANK 3
HgeneANKRD12chr18:9221997chr18:9931807ENST00000400020+712184_2132912040.0RepeatNote=ANK 1
HgeneANKRD12chr18:9221997chr18:9931807ENST00000400020+712217_2462912040.0RepeatNote=ANK 2
HgeneANKRD12chr18:9221997chr18:9931807ENST00000400020+712250_2802912040.0RepeatNote=ANK 3
TgeneVAPAchr18:9221997chr18:9931807ENST0000034054107169_20526295.0Coiled coilOntology_term=ECO:0000255
TgeneVAPAchr18:9221997chr18:9931807ENST0000040000006169_20526250.0Coiled coilOntology_term=ECO:0000255
TgeneVAPAchr18:9221997chr18:9931807ENST0000034054107228_24826295.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneVAPAchr18:9221997chr18:9931807ENST0000040000006228_24826250.0TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVAPAchr18:9221997chr18:9931807ENST000003405410714_13126295.0DomainMSP
TgeneVAPAchr18:9221997chr18:9931807ENST000004000000614_13126250.0DomainMSP
TgeneVAPAchr18:9221997chr18:9931807ENST00000340541072_22726295.0Topological domainCytoplasmic
TgeneVAPAchr18:9221997chr18:9931807ENST00000400000062_22726250.0Topological domainCytoplasmic


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Fusion Gene Sequence for ANKRD12-VAPA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4584_4584_1_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000262126_VAPA_chr18_9931807_ENST00000340541_length(transcript)=2136nt_BP=1183nt
AATCGCGGGGCGACGCTGTCCTGGGAGCGAGGAGGCTGTGGTGAGAGACGGACCGAGACCGGAGATGTTTTCAAGCCCGGCTCCGGCGGC
TTTACAGGCGGCTGCAGCGGCGACGAAGACAACGACAGCGACGGCTACGCCGAAGCACTCGTTCCGGGGGTGAAGCCTCCTGCGCCGGCC
TTGCCTCGGATCCAGGATGAGAAGACTGATAAAAGAAGAAGCTAGCTGAACAGCTGTAAAATGCCCAAATCTGGGTTCACAAAACCAATT
CAGAGTGAAAATTCTGACAGTGACAGCAATATGGTAGAGAAACCATATGGAAGAAAGAGTAAAGACAAGATTGCATCCTACAGCAAAACT
CCAAAAATTGAACGAAGTGATGTGAGCAAGGAGATGAAAGAGAAATCATCCATGAAACGTAAACTTCCTTTTACTATTAGCCCATCAAGA
AATGAAGAACGAGATTCAGACACAGATTCAGATCCAGGACATACAAGTGAAAATTGGGGGGAGAGACTTATATCTTCTTACAGGACATAC
TCAGAGAAAGAAGGTCCAGAAAAGAAGAAGACAAAAAAGGAAGCTGGAAATAAGAAATCCACACCAGTTAGCATTCTTTTTGGTTATCCA
CTCTCTGAGCGAAAACAGATGGCACTTCTTATGCAGATGACAGCAAGAGACAACAGTCCAGATTCCACACCAAATCATCCATCACAAACA
ACGCCTGCCCAAAAGAAAACTCCCAGTTCTTCATCTCGACAGAAAGATAAAGTTAATAAAAGAAATGAACGTGGTGAAACTCCTTTACAC
ATGGCTGCTATTCGAGGAGATGTGAAACAAGTTAAAGAATTAATAAGTTTAGGGGCAAATGTGAATGTGAAAGATTTTGCAGGTTGGACA
CCACTGCATGAAGCTTGCAATGTTGGATATTACGATGTTGCTAAGATACTTATAGCAGCTGGAGCAGATGTTAACACACAAGGATTAGAT
GATGACACTCCACTCCATGATTCTGCTAGTAGTGGGCACAGAGATATAGTAAAGCTGTTACTTCGTCACGGTGGAAATCCATTTCAAGCT
AATAAACATGGGGAGCGTCCAGTGGATGTAGCAGAAACAGAGGAGTTGGAGTTGCTACTAAAAAGAGAGGTGCCTTTATCTGATGATGAT
GAAAGTTACACAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAG
ACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCC
TTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTG
TGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGGTATAACT
CCACCAGGGAATGCTCCGACTGTCACTTCAATGAGCAGCATCAACAACACAGTTGCAACACCTGCCAGTTATCACACGAAGGATGACCCC
AGGGGACTCAGTGTGTTGAAACAGGAGAAACAGAAGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGA
CCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATG
AAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACT
GCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTC
ATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGT

>4584_4584_1_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000262126_VAPA_chr18_9931807_ENST00000340541_length(amino acids)=587AA_BP=1
MNSCKMPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHT
SENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQK
DKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRD
IVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGI
IDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLGITPPGNAPTVTSMSSIN
NTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLR

--------------------------------------------------------------
>4584_4584_2_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000262126_VAPA_chr18_9931807_ENST00000400000_length(transcript)=7664nt_BP=1183nt
AATCGCGGGGCGACGCTGTCCTGGGAGCGAGGAGGCTGTGGTGAGAGACGGACCGAGACCGGAGATGTTTTCAAGCCCGGCTCCGGCGGC
TTTACAGGCGGCTGCAGCGGCGACGAAGACAACGACAGCGACGGCTACGCCGAAGCACTCGTTCCGGGGGTGAAGCCTCCTGCGCCGGCC
TTGCCTCGGATCCAGGATGAGAAGACTGATAAAAGAAGAAGCTAGCTGAACAGCTGTAAAATGCCCAAATCTGGGTTCACAAAACCAATT
CAGAGTGAAAATTCTGACAGTGACAGCAATATGGTAGAGAAACCATATGGAAGAAAGAGTAAAGACAAGATTGCATCCTACAGCAAAACT
CCAAAAATTGAACGAAGTGATGTGAGCAAGGAGATGAAAGAGAAATCATCCATGAAACGTAAACTTCCTTTTACTATTAGCCCATCAAGA
AATGAAGAACGAGATTCAGACACAGATTCAGATCCAGGACATACAAGTGAAAATTGGGGGGAGAGACTTATATCTTCTTACAGGACATAC
TCAGAGAAAGAAGGTCCAGAAAAGAAGAAGACAAAAAAGGAAGCTGGAAATAAGAAATCCACACCAGTTAGCATTCTTTTTGGTTATCCA
CTCTCTGAGCGAAAACAGATGGCACTTCTTATGCAGATGACAGCAAGAGACAACAGTCCAGATTCCACACCAAATCATCCATCACAAACA
ACGCCTGCCCAAAAGAAAACTCCCAGTTCTTCATCTCGACAGAAAGATAAAGTTAATAAAAGAAATGAACGTGGTGAAACTCCTTTACAC
ATGGCTGCTATTCGAGGAGATGTGAAACAAGTTAAAGAATTAATAAGTTTAGGGGCAAATGTGAATGTGAAAGATTTTGCAGGTTGGACA
CCACTGCATGAAGCTTGCAATGTTGGATATTACGATGTTGCTAAGATACTTATAGCAGCTGGAGCAGATGTTAACACACAAGGATTAGAT
GATGACACTCCACTCCATGATTCTGCTAGTAGTGGGCACAGAGATATAGTAAAGCTGTTACTTCGTCACGGTGGAAATCCATTTCAAGCT
AATAAACATGGGGAGCGTCCAGTGGATGTAGCAGAAACAGAGGAGTTGGAGTTGCTACTAAAAAGAGAGGTGCCTTTATCTGATGATGAT
GAAAGTTACACAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAG
ACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCC
TTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTG
TGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGAATGATATG
GAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACA
AGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGG
CTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTT
GTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTT
TTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATAT
AGGCTTTGCCTTTAATGATCTCTTACGGTTAGAAAACACAATAAAAACAAACTGTTCGGCTACTGGACAGGTTGTATATTACCAGATCAT
CACTAGCAGATGTCAGTTGCACATTGAGTCCTTTATGAAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAG
AATTGTTCAGAGTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATT
GCTAATCCCACTCATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGC
TAATATCATGGCAGAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACA
TAAAAAAAAATAAAACTGTTAACAGATTCTTGCTCGATAGCTTGTTTGTGTCTGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCA
CTTGAAATTATGATGCAAAGGTTTCTCTTGCATTGAAACCCTCTTGGATATTACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGA
AAGGAGTTGATTAAATTTTAAGGTACCACTGGTATTTTGGGAGATTATAATCAGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAG
AATAGAAGTTATGTGATTTCAGTGAGTTGATGTGTACAGCATGGCTGTGCTCCATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGT
TCTCAAGGAAGATTTAACTCTCTTTGGTTTTAAATTACTTTTTAACCAGCCTAATAAATAAGTCTTACTACTTTTCATAATATTTCATAA
TAGTTAAAAGTAGGTGTTTTTTTCGTGCTCAATTTGGCACTCAAAATAATGTTCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGG
AATTTTCTTTATGAAAAATGATTTTAGCCTTTGCAAATGTTAACCATGTGAAACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGAT
ACTTTCCTGCACTTAGGTTTGTCCTATTCTTCATTTATTCATACTAGGATAGAAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCT
ACATACAATCTAGTACAAGTGAATTTTTATTCTTAAACATAGGTGTGTTGGCTCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAAT
TGGATTTTAGAACTGGATGTGGTGCAGTGAAGTATTTTAGGCCCAGGTCTGTGTACACATTTTATAGAAGAATGAAGTACTCTGAAGTAT
TTTGGTTGCCTTTTCATTTCAACTGTGTTTTGAATTTGTCAGATCACACATATATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAAC
CTCTTGCTTGTGTGCAAAAGTTCCTAAAAGGAAACACAAGTAATGCCTATCCATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTG
CTGTATGCTTTACTGTCTTTGTAAAAATCCCCCTCTCCCCTTTTCTGGTAACTGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCC
CATAAATGCAGAATCAGTAATTCCTTGGCTTAAAGCTCTTATATAATCAATATTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCT
ATCTTTTTTTAAAGAAATTAAGTTCTTGAAAATTTAGCCAAATCCCGTTTTATGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTT
TGTTCTATGGTTGAGAAATCTGAGGCCTTACGAAGGTTAAGAGAACTTTCCCCGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAG
ATATCTGGTCTGTTGACTCTAGCTCAGTGTCTTCTGGTAACTGTTGAAAATTGTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAA
ATGCTATTTATAATAACAAGTATATGTGAAATTTCTTATTGTAAGACTACTACCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGG
CTAGAAATGCCTCCCACATTGGTAATAAACATTACAAAATACAATGTATTTTTAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTG
CTTTTGAGATAGATTGTAGTCTGGGTAGCATCTTTAAAATGTATGTGGGCTTAACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAG
GTGAGACTCTGTTTCTGTTATTTTTAATTGCTGTATGAAATGTGATCAGATTATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTG
TATTAATTGACTGATAATATGATAATATAGAGATTAAATTGTTTGTCTTCATTCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGC
TTACTTGTATATGTAAGCATGAGGGAAATACACTGTTGCTAATACTGAAATTACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACA
CTGAATGCACTAGCTTCCTTCGTTCTATAACTAATGTACCTTAACTTCCCCCATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTG
AGTGTGTGGTATGTTCCCTTAAAAAAAAATGACACTTGGAAGAAAAATGTATGAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTT
CTTTTTTTTTTTGAGACAGAGTCTTGCTTTGTTGCCCAGGCTGGAGGGCAGTGGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGG
TTCAAGTGATTCTCATGGCTCAGCCGCCTGAGTAGCTGGGATTACAGGTGTGAGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGA
GACAAGGTTTCACCATGTTGGTCAGGCTGGGCTCAAACTCCTGAATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAG
CTGCCGCACCCAGCCAAGAAAAATAATACTCTTAAATACTTAGATGTTCACCTAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAA
CTGTAATCTTTCAGATTACACCACTTTGAAAACAAGTTTTAACAGTAGGGTAAAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCT
TCTACCACTTTAGAGACATTCAAGTAATAGTTTTCTTAGAGCTTTGCACATTCCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCG
AGGGAAGGATCAATGCTTATTACCATTTGGAAAAACGAAGATCAGAAGGTAAATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACC
ATTCATGAATAAACTTTAAAAATGTGAAGTGTCCTTTTCCTTTTCACAATACAAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTA
TATCCTGTTAAGCATTAATAGCTAATCACTGGGACTTGAATTCTGATGGCAGATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTT
TAGTAGGAAGTGAGAACAGCTGATTTTCATGCCACGTTTCATAGCCCCACTTTTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTG
GCATCTTGGGAATGAATGCCCAGCCGCTCGTGGGTTGGTGCAAAGAAGTATAAACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCC
CTTCTGACACAGTGTGTGCACTTCAGGCAATTTTTGGAAAATATAAAAAATTCCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAAC
ATTTCATTCATTTCCCTGTAATATTAATGTTCTTTAAGCATAATCACTAATTATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGT
GGTTTATTGAAAACCAAGTATAAATGTGACTAAAAGCATTTTGCTTTGTTTTTATAGTTAACTTTCTTAAGGTTATGGACATTTTATAAT
GTAACATTTGATTGGCCTGGCCTCTTGACAATTCCCTTCTAGTTATGCATATCCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTT
CTTGTTTTCCAGTTGTTGCTATGTATAACACCCATCTTGAAAGAGAGTATATAGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTC
AACTATAGCAGTACCTTAACTCATGATGAGCTTAGGAACATAAAAGATAATTGTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATT
GGTCTGGGGTGGAGATCTGGCATGGTAGTTTTTTTCAAGCTCCAATCATCGGCCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAG
GCAGATATGAAGTAGATTTAATTAAGACTTGACTTCAGCAATACAGGGGAACTTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACT
GTTAGGTATTGCTTAAAAAAAATTGCATAAAAGCTTTGCTTGTCAAGTTAGGATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAAT
AAATGAGCTGTCATCGCAAAAAGGCGATTTGAGAAATGTGGGCTTCAGTATTAATTGCCATTTTGCTGACACCCAGTGTACCTACCTACC
TGAGAAATTTATTTTGTCCATCATGTATTTCTCAAAGCAAAAGGTGGTTTTCAAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTT
TTACGTCAGCTCATTTCATCATCATTGATAACTTGTGAAATACTTATCTCCATCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAA
TTAGCTCAAGTCTACACAGCTGAAGTAGCAGAGAAAGTGGGATCTAGATGGTCTGATCCTAGTGATCTACCATATGAAGGACATAGTTTG
TGTCCTGGTCCAAGTCAAATATTGACTCCTCACAAACAGTAAGTATGGCAATTTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTA
TTATTTGTGAAATGTCTTTAAGATTTTTGGTCTTAAATTTTTGAAGACTGCTTTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAA
CTCCTGCCCACTAACAATCTCAGTCCGTGAACAAAACCAACATGAACATTCCTAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATA
GAATTTATGGAAATGGCTTATGTAACCTACAAGACTGGAGAACAGAATGTGACTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTA
AAGCAAGAGTTTTTTATAATTGACTTTGTGGTCTAAATTCTTGATACTGTTTATAATTCTACAAAGAACAAAAATTGTTATGTACTATAG
GCACTTAAGAACCCTGAGGAAAAATAATACAATGTGTGTGTGTGAGAGAGAGAGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAA
AAAAAAAAAATGTGGAGGGTTGAAATGGTAAGGAATTGGAATCTTTTGTATTTTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGA
GGTTTGTTAGGAATTACAGTTGTGGGGAGCAAACTTTCTTTTTTGTGCTGTTTTAATTCAAAATGTATATCCTTAATTGTATATAATATG
TAGATAAATATATGAGGGTATTAAGCTACTTTGAATTAAATTTAAGGATATATTTCACATGAAAACAAATACAAACGAGAATCAAAATAA

>4584_4584_2_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000262126_VAPA_chr18_9931807_ENST00000400000_length(amino acids)=542AA_BP=1
MNSCKMPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTDSDPGHT
SENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQK
DKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRD
IVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLSDDDESYTGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGI
IDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDG
PMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTSPLPSLLVVIAAIFIGFFLGKF

--------------------------------------------------------------
>4584_4584_3_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000383440_VAPA_chr18_9931807_ENST00000340541_length(transcript)=2084nt_BP=1131nt
GTGCTCGCGTCGCAGCCAATCGCGGGGCGACGCTGTCCTGGGAGCGAGGAGGCTGTGGTGAGAGACGGACCGAGACCGGAGATGTTTTCA
AGCCCGGCTCCGGCGGCTTTACAGGCGGCTGCAGCGGCGACGAAGACAACGACAGCGACGGCTACGCCGAAGCACTCGTTCCGGGGGTGA
AGCCTCCTGCGCCGGCCTTGCCTCGGATCCAGGATGAGAAGACTGATAAAAGAAGAAGCTAGCTGAACAGCTGTAAAATGCCCAAATCTG
GGTTCACAAAACCAATTCAGAGTGAAAATTCTGACAGTGACAGCAATATGGTAGAGAAACCATATGGAAGAAAGAGTAAAGACAAGATTG
CATCCTACAGCAAAACTCCAAAAATTGAACGAAGTGATGTGAGCAAGGAGATGAAAGAGAAATCATCCATGAAACGTAAACTTCCTTTTA
CTATTAGCCCATCAAGAAATGAAGAACGAGATTCAGACACAGAGAAAGAAGGTCCAGAAAAGAAGAAGACAAAAAAGGAAGCTGGAAATA
AGAAATCCACACCAGTTAGCATTCTTTTTGGTTATCCACTCTCTGAGCGAAAACAGATGGCACTTCTTATGCAGATGACAGCAAGAGACA
ACAGTCCAGATTCCACACCAAATCATCCATCACAAACAACGCCTGCCCAAAAGAAAACTCCCAGTTCTTCATCTCGACAGAAAGATAAAG
TTAATAAAAGAAATGAACGTGGTGAAACTCCTTTACACATGGCTGCTATTCGAGGAGATGTGAAACAAGTTAAAGAATTAATAAGTTTAG
GGGCAAATGTGAATGTGAAAGATTTTGCAGGTTGGACACCACTGCATGAAGCTTGCAATGTTGGATATTACGATGTTGCTAAGATACTTA
TAGCAGCTGGAGCAGATGTTAACACACAAGGATTAGATGATGACACTCCACTCCATGATTCTGCTAGTAGTGGGCACAGAGATATAGTAA
AGCTGTTACTTCGTCACGGTGGAAATCCATTTCAAGCTAATAAACATGGGGAGCGTCCAGTGGATGTAGCAGAAACAGAGGAGTTGGAGT
TGCTACTAAAAAGAGAGGTGCCTTTATCTGATGATGATGAAAGTTACACAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGC
GAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACC
CAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAA
TTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTAT
TTGAAATGCCCAATGAAAATGATAAATTGGGTATAACTCCACCAGGGAATGCTCCGACTGTCACTTCAATGAGCAGCATCAACAACACAG
TTGCAACACCTGCCAGTTATCACACGAAGGATGACCCCAGGGGACTCAGTGTGTTGAAACAGGAGAAACAGAAGAATGATATGGAACCTA
GCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAAC
TAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAA
AGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAA
TTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTT
GACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTT

>4584_4584_3_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000383440_VAPA_chr18_9931807_ENST00000340541_length(amino acids)=564AA_BP=1
MNSCKMPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEK
KKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDV
KQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPV
DVAETEELELLLKREVPLSDDDESYTGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEK
SKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQ
EKQKNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVT

--------------------------------------------------------------
>4584_4584_4_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000383440_VAPA_chr18_9931807_ENST00000400000_length(transcript)=7612nt_BP=1131nt
GTGCTCGCGTCGCAGCCAATCGCGGGGCGACGCTGTCCTGGGAGCGAGGAGGCTGTGGTGAGAGACGGACCGAGACCGGAGATGTTTTCA
AGCCCGGCTCCGGCGGCTTTACAGGCGGCTGCAGCGGCGACGAAGACAACGACAGCGACGGCTACGCCGAAGCACTCGTTCCGGGGGTGA
AGCCTCCTGCGCCGGCCTTGCCTCGGATCCAGGATGAGAAGACTGATAAAAGAAGAAGCTAGCTGAACAGCTGTAAAATGCCCAAATCTG
GGTTCACAAAACCAATTCAGAGTGAAAATTCTGACAGTGACAGCAATATGGTAGAGAAACCATATGGAAGAAAGAGTAAAGACAAGATTG
CATCCTACAGCAAAACTCCAAAAATTGAACGAAGTGATGTGAGCAAGGAGATGAAAGAGAAATCATCCATGAAACGTAAACTTCCTTTTA
CTATTAGCCCATCAAGAAATGAAGAACGAGATTCAGACACAGAGAAAGAAGGTCCAGAAAAGAAGAAGACAAAAAAGGAAGCTGGAAATA
AGAAATCCACACCAGTTAGCATTCTTTTTGGTTATCCACTCTCTGAGCGAAAACAGATGGCACTTCTTATGCAGATGACAGCAAGAGACA
ACAGTCCAGATTCCACACCAAATCATCCATCACAAACAACGCCTGCCCAAAAGAAAACTCCCAGTTCTTCATCTCGACAGAAAGATAAAG
TTAATAAAAGAAATGAACGTGGTGAAACTCCTTTACACATGGCTGCTATTCGAGGAGATGTGAAACAAGTTAAAGAATTAATAAGTTTAG
GGGCAAATGTGAATGTGAAAGATTTTGCAGGTTGGACACCACTGCATGAAGCTTGCAATGTTGGATATTACGATGTTGCTAAGATACTTA
TAGCAGCTGGAGCAGATGTTAACACACAAGGATTAGATGATGACACTCCACTCCATGATTCTGCTAGTAGTGGGCACAGAGATATAGTAA
AGCTGTTACTTCGTCACGGTGGAAATCCATTTCAAGCTAATAAACATGGGGAGCGTCCAGTGGATGTAGCAGAAACAGAGGAGTTGGAGT
TGCTACTAAAAAGAGAGGTGCCTTTATCTGATGATGATGAAAGTTACACAGGCCCCTTCACAGATGTAGTCACTACAAATCTTAAATTGC
GAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACAGTGGAATTATTGACC
CAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGTTTATGGTACAGACAA
TTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCAAATTGAGATGCGTAT
TTGAAATGCCCAATGAAAATGATAAATTGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGC
CAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTAT
CAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCT
TCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGT
AGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGG
CCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCTTTAATGATCTCTTACGGTTAGAAAACACAATAAAAACAAAC
TGTTCGGCTACTGGACAGGTTGTATATTACCAGATCATCACTAGCAGATGTCAGTTGCACATTGAGTCCTTTATGAAATTCATAAATAAA
GAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGTCTTGTAAATGTTATTTTAATAATCCCTTTAAATTTTATC
TGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTCATTCAGGAAATGCCAAGAGGTATTCCTTGGGGAAATGGT
GCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGGCAGAATTTTTCTTATCCCTTGTGAGGCAGTTGTTGACTGAG
TTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAATAAAACTGTTAACAGATTCTTGCTCGATAGCTTGTTTGTGTC
TGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCACTTGAAATTATGATGCAAAGGTTTCTCTTGCATTGAAACCCTCTTGGATATT
ACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGAAAGGAGTTGATTAAATTTTAAGGTACCACTGGTATTTTGGGAGATTATAATC
AGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAGAATAGAAGTTATGTGATTTCAGTGAGTTGATGTGTACAGCATGGCTGTGCTC
CATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGTTCTCAAGGAAGATTTAACTCTCTTTGGTTTTAAATTACTTTTTAACCAGCCT
AATAAATAAGTCTTACTACTTTTCATAATATTTCATAATAGTTAAAAGTAGGTGTTTTTTTCGTGCTCAATTTGGCACTCAAAATAATGT
TCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGGAATTTTCTTTATGAAAAATGATTTTAGCCTTTGCAAATGTTAACCATGTGAA
ACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGATACTTTCCTGCACTTAGGTTTGTCCTATTCTTCATTTATTCATACTAGGATAG
AAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCTACATACAATCTAGTACAAGTGAATTTTTATTCTTAAACATAGGTGTGTTGGC
TCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAATTGGATTTTAGAACTGGATGTGGTGCAGTGAAGTATTTTAGGCCCAGGTCTGT
GTACACATTTTATAGAAGAATGAAGTACTCTGAAGTATTTTGGTTGCCTTTTCATTTCAACTGTGTTTTGAATTTGTCAGATCACACATA
TATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAACCTCTTGCTTGTGTGCAAAAGTTCCTAAAAGGAAACACAAGTAATGCCTATCC
ATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTGCTGTATGCTTTACTGTCTTTGTAAAAATCCCCCTCTCCCCTTTTCTGGTAAC
TGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCCCATAAATGCAGAATCAGTAATTCCTTGGCTTAAAGCTCTTATATAATCAATA
TTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCTATCTTTTTTTAAAGAAATTAAGTTCTTGAAAATTTAGCCAAATCCCGTTTTA
TGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTTTGTTCTATGGTTGAGAAATCTGAGGCCTTACGAAGGTTAAGAGAACTTTCCC
CGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAGATATCTGGTCTGTTGACTCTAGCTCAGTGTCTTCTGGTAACTGTTGAAAATT
GTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAAATGCTATTTATAATAACAAGTATATGTGAAATTTCTTATTGTAAGACTACTA
CCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGGCTAGAAATGCCTCCCACATTGGTAATAAACATTACAAAATACAATGTATTTT
TAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTGCTTTTGAGATAGATTGTAGTCTGGGTAGCATCTTTAAAATGTATGTGGGCTT
AACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAGGTGAGACTCTGTTTCTGTTATTTTTAATTGCTGTATGAAATGTGATCAGATT
ATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTGTATTAATTGACTGATAATATGATAATATAGAGATTAAATTGTTTGTCTTCAT
TCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGCTTACTTGTATATGTAAGCATGAGGGAAATACACTGTTGCTAATACTGAAATT
ACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACACTGAATGCACTAGCTTCCTTCGTTCTATAACTAATGTACCTTAACTTCCCCC
ATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTGAGTGTGTGGTATGTTCCCTTAAAAAAAAATGACACTTGGAAGAAAAATGTAT
GAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTTCTTTTTTTTTTTGAGACAGAGTCTTGCTTTGTTGCCCAGGCTGGAGGGCAGT
GGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGGTTCAAGTGATTCTCATGGCTCAGCCGCCTGAGTAGCTGGGATTACAGGTGTG
AGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGTCAGGCTGGGCTCAAACTCCTGAATCCGCCT
GCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCGCACCCAGCCAAGAAAAATAATACTCTTAAATACTTAGATGTTCACC
TAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAACTGTAATCTTTCAGATTACACCACTTTGAAAACAAGTTTTAACAGTAGGGTA
AAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCTTCTACCACTTTAGAGACATTCAAGTAATAGTTTTCTTAGAGCTTTGCACATT
CCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCGAGGGAAGGATCAATGCTTATTACCATTTGGAAAAACGAAGATCAGAAGGTAA
ATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACCATTCATGAATAAACTTTAAAAATGTGAAGTGTCCTTTTCCTTTTCACAATAC
AAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTATATCCTGTTAAGCATTAATAGCTAATCACTGGGACTTGAATTCTGATGGCAG
ATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTTTAGTAGGAAGTGAGAACAGCTGATTTTCATGCCACGTTTCATAGCCCCACTT
TTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTGGCATCTTGGGAATGAATGCCCAGCCGCTCGTGGGTTGGTGCAAAGAAGTATA
AACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCCCTTCTGACACAGTGTGTGCACTTCAGGCAATTTTTGGAAAATATAAAAAATT
CCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAACATTTCATTCATTTCCCTGTAATATTAATGTTCTTTAAGCATAATCACTAATT
ATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGTGGTTTATTGAAAACCAAGTATAAATGTGACTAAAAGCATTTTGCTTTGTTTT
TATAGTTAACTTTCTTAAGGTTATGGACATTTTATAATGTAACATTTGATTGGCCTGGCCTCTTGACAATTCCCTTCTAGTTATGCATAT
CCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTTCTTGTTTTCCAGTTGTTGCTATGTATAACACCCATCTTGAAAGAGAGTATAT
AGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTCAACTATAGCAGTACCTTAACTCATGATGAGCTTAGGAACATAAAAGATAATT
GTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATTGGTCTGGGGTGGAGATCTGGCATGGTAGTTTTTTTCAAGCTCCAATCATCGG
CCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAGGCAGATATGAAGTAGATTTAATTAAGACTTGACTTCAGCAATACAGGGGAAC
TTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACTGTTAGGTATTGCTTAAAAAAAATTGCATAAAAGCTTTGCTTGTCAAGTTAGG
ATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAATAAATGAGCTGTCATCGCAAAAAGGCGATTTGAGAAATGTGGGCTTCAGTATT
AATTGCCATTTTGCTGACACCCAGTGTACCTACCTACCTGAGAAATTTATTTTGTCCATCATGTATTTCTCAAAGCAAAAGGTGGTTTTC
AAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTTTTACGTCAGCTCATTTCATCATCATTGATAACTTGTGAAATACTTATCTCCA
TCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAATTAGCTCAAGTCTACACAGCTGAAGTAGCAGAGAAAGTGGGATCTAGATGGT
CTGATCCTAGTGATCTACCATATGAAGGACATAGTTTGTGTCCTGGTCCAAGTCAAATATTGACTCCTCACAAACAGTAAGTATGGCAAT
TTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTATTATTTGTGAAATGTCTTTAAGATTTTTGGTCTTAAATTTTTGAAGACTGCT
TTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAACTCCTGCCCACTAACAATCTCAGTCCGTGAACAAAACCAACATGAACATTCC
TAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATAGAATTTATGGAAATGGCTTATGTAACCTACAAGACTGGAGAACAGAATGTGA
CTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTAAAGCAAGAGTTTTTTATAATTGACTTTGTGGTCTAAATTCTTGATACTGTTT
ATAATTCTACAAAGAACAAAAATTGTTATGTACTATAGGCACTTAAGAACCCTGAGGAAAAATAATACAATGTGTGTGTGTGAGAGAGAG
AGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAATGTGGAGGGTTGAAATGGTAAGGAATTGGAATCTTTTGTATT
TTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGAGGTTTGTTAGGAATTACAGTTGTGGGGAGCAAACTTTCTTTTTTGTGCTGTT
TTAATTCAAAATGTATATCCTTAATTGTATATAATATGTAGATAAATATATGAGGGTATTAAGCTACTTTGAATTAAATTTAAGGATATA

>4584_4584_4_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000383440_VAPA_chr18_9931807_ENST00000400000_length(amino acids)=519AA_BP=1
MNSCKMPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEK
KKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDV
KQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPV
DVAETEELELLLKREVPLSDDDESYTGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEK
SKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECK

--------------------------------------------------------------
>4584_4584_5_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000400020_VAPA_chr18_9931807_ENST00000340541_length(transcript)=2189nt_BP=1236nt
CGGCCGCTCGGGCCGGGAGCGTCGGAGGTACCCGGGTCCTGGGAGAGGTGGATGAAATCAAGAAGGGGAAATTGCTGCTTTAGTAGTGTC
CGGGGAAAGAGCAGCCACTCTACAGTTCTGTCTTAAATGCCAGTGTAAAATAACCTTGCCGCATTGGACAGGCAGTTCCCGTCATCGTTT
TTCAAGTACCCACTTGTGATGCTTCAAGACCCCTGGAGCACGTCAGGTTCTTAGATCTCGTTTTGAGGAGTGATGTGGAGTGACGCATCC
TTACAGATCCCAAAGCGTTGAATAAACGGTTGTACAAAGAGATCCAGGATGAGAAGACTGATAAAAGAAGAAGCTAGCTGAACAGCTGTA
AAATGCCCAAATCTGGGTTCACAAAACCAATTCAGAGTGAAAATTCTGACAGTGACAGCAATATGGTAGAGAAACCATATGGAAGAAAGA
GTAAAGACAAGATTGCATCCTACAGCAAAACTCCAAAAATTGAACGAAGTGATGTGAGCAAGGAGATGAAAGAGAAATCATCCATGAAAC
GTAAACTTCCTTTTACTATTAGCCCATCAAGAAATGAAGAACGAGATTCAGACACAGAGAAAGAAGGTCCAGAAAAGAAGAAGACAAAAA
AGGAAGCTGGAAATAAGAAATCCACACCAGTTAGCATTCTTTTTGGTTATCCACTCTCTGAGCGAAAACAGATGGCACTTCTTATGCAGA
TGACAGCAAGAGACAACAGTCCAGATTCCACACCAAATCATCCATCACAAACAACGCCTGCCCAAAAGAAAACTCCCAGTTCTTCATCTC
GACAGAAAGATAAAGTTAATAAAAGAAATGAACGTGGTGAAACTCCTTTACACATGGCTGCTATTCGAGGAGATGTGAAACAAGTTAAAG
AATTAATAAGTTTAGGGGCAAATGTGAATGTGAAAGATTTTGCAGGTTGGACACCACTGCATGAAGCTTGCAATGTTGGATATTACGATG
TTGCTAAGATACTTATAGCAGCTGGAGCAGATGTTAACACACAAGGATTAGATGATGACACTCCACTCCATGATTCTGCTAGTAGTGGGC
ACAGAGATATAGTAAAGCTGTTACTTCGTCACGGTGGAAATCCATTTCAAGCTAATAAACATGGGGAGCGTCCAGTGGATGTAGCAGAAA
CAGAGGAGTTGGAGTTGCTACTAAAAAGAGAGGTGCCTTTATCTGATGATGATGAAAGTTACACAGGCCCCTTCACAGATGTAGTCACTA
CAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACA
GTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGT
TTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCA
AATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGGGTATAACTCCACCAGGGAATGCTCCGACTGTCACTTCAATGAGCA
GCATCAACAACACAGTTGCAACACCTGCCAGTTATCACACGAAGGATGACCCCAGGGGACTCAGTGTGTTGAAACAGGAGAAACAGAAGA
ATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGCAAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATA
CCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAGAAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAG
GTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAACCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTT
CACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAGGGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTT
TTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATTTCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAG

>4584_4584_5_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000400020_VAPA_chr18_9931807_ENST00000340541_length(amino acids)=564AA_BP=1
MNSCKMPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEK
KKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDV
KQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPV
DVAETEELELLLKREVPLSDDDESYTGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEK
SKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQ
EKQKNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVT

--------------------------------------------------------------
>4584_4584_6_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000400020_VAPA_chr18_9931807_ENST00000400000_length(transcript)=7717nt_BP=1236nt
CGGCCGCTCGGGCCGGGAGCGTCGGAGGTACCCGGGTCCTGGGAGAGGTGGATGAAATCAAGAAGGGGAAATTGCTGCTTTAGTAGTGTC
CGGGGAAAGAGCAGCCACTCTACAGTTCTGTCTTAAATGCCAGTGTAAAATAACCTTGCCGCATTGGACAGGCAGTTCCCGTCATCGTTT
TTCAAGTACCCACTTGTGATGCTTCAAGACCCCTGGAGCACGTCAGGTTCTTAGATCTCGTTTTGAGGAGTGATGTGGAGTGACGCATCC
TTACAGATCCCAAAGCGTTGAATAAACGGTTGTACAAAGAGATCCAGGATGAGAAGACTGATAAAAGAAGAAGCTAGCTGAACAGCTGTA
AAATGCCCAAATCTGGGTTCACAAAACCAATTCAGAGTGAAAATTCTGACAGTGACAGCAATATGGTAGAGAAACCATATGGAAGAAAGA
GTAAAGACAAGATTGCATCCTACAGCAAAACTCCAAAAATTGAACGAAGTGATGTGAGCAAGGAGATGAAAGAGAAATCATCCATGAAAC
GTAAACTTCCTTTTACTATTAGCCCATCAAGAAATGAAGAACGAGATTCAGACACAGAGAAAGAAGGTCCAGAAAAGAAGAAGACAAAAA
AGGAAGCTGGAAATAAGAAATCCACACCAGTTAGCATTCTTTTTGGTTATCCACTCTCTGAGCGAAAACAGATGGCACTTCTTATGCAGA
TGACAGCAAGAGACAACAGTCCAGATTCCACACCAAATCATCCATCACAAACAACGCCTGCCCAAAAGAAAACTCCCAGTTCTTCATCTC
GACAGAAAGATAAAGTTAATAAAAGAAATGAACGTGGTGAAACTCCTTTACACATGGCTGCTATTCGAGGAGATGTGAAACAAGTTAAAG
AATTAATAAGTTTAGGGGCAAATGTGAATGTGAAAGATTTTGCAGGTTGGACACCACTGCATGAAGCTTGCAATGTTGGATATTACGATG
TTGCTAAGATACTTATAGCAGCTGGAGCAGATGTTAACACACAAGGATTAGATGATGACACTCCACTCCATGATTCTGCTAGTAGTGGGC
ACAGAGATATAGTAAAGCTGTTACTTCGTCACGGTGGAAATCCATTTCAAGCTAATAAACATGGGGAGCGTCCAGTGGATGTAGCAGAAA
CAGAGGAGTTGGAGTTGCTACTAAAAAGAGAGGTGCCTTTATCTGATGATGATGAAAGTTACACAGGCCCCTTCACAGATGTAGTCACTA
CAAATCTTAAATTGCGAAATCCATCGGATAGAAAAGTGTGTTTCAAAGTGAAGACTACAGCACCTCGCCGGTACTGTGTGAGGCCCAACA
GTGGAATTATTGACCCAGGGTCAACTGTGACTGTTTCAGTAATGCTACAGCCCTTTGACTATGATCCGAATGAAAAGAGTAAACACAAGT
TTATGGTACAGACAATTTTTGCTCCACCAAACACTTCAGATATGGAAGCTGTGTGGAAAGAGGCAAAACCTGATGAATTAATGGATTCCA
AATTGAGATGCGTATTTGAAATGCCCAATGAAAATGATAAATTGAATGATATGGAACCTAGCAAAGCTGTTCCACTGAATGCATCTAAGC
AAGATGGACCTATGCCAAAACCACACAGTGTTTCACTTAATGATACCGAAACAAGGAAACTAATGGAAGAGTGTAAAAGACTTCAGGGAG
AAATGATGAAGCTATCAGAAGAAAATCGGCACCTGAGAGATGAAGGTTTAAGGCTCAGAAAGGTAGCACATTCGGATAAACCTGGATCAA
CCTCAACTGCATCCTTCAGAGATAATGTCACCAGTCCTCTTCCTTCACTTCTTGTTGTAATTGCAGCCATTTTCATTGGATTCTTTCTAG
GGAAATTCATCTTGTAGAGTGAAGCATGCAGAGTGCTGTTTCTTTTTTTTTTTTTCTCTTGACCAGAAAAAGATTTGTTTACCTACCATT
TCATTGGTAGTATGGCCCACGGTGACCATTTTTTTGTGTGTACAGCGTCATATAGGCTTTGCCTTTAATGATCTCTTACGGTTAGAAAAC
ACAATAAAAACAAACTGTTCGGCTACTGGACAGGTTGTATATTACCAGATCATCACTAGCAGATGTCAGTTGCACATTGAGTCCTTTATG
AAATTCATAAATAAAGAATTGTTCTTTCTTTGTGGTTTTAATAAGAGTTCAAGAATTGTTCAGAGTCTTGTAAATGTTATTTTAATAATC
CCTTTAAATTTTATCTGTTGCTGTTACCTCTTGAAATATGATTTATTTAGATTGCTAATCCCACTCATTCAGGAAATGCCAAGAGGTATT
CCTTGGGGAAATGGTGCCTCTTACAGTGTAAATTTTTCCTCCTTTACCTTTGCTAATATCATGGCAGAATTTTTCTTATCCCTTGTGAGG
CAGTTGTTGACTGAGTTTTTCATCCTTACAATCCTGTCCCATGGTATTTAACATAAAAAAAAATAAAACTGTTAACAGATTCTTGCTCGA
TAGCTTGTTTGTGTCTGTCGTGTTATTAGAGGGAACTCCACTATATATGGTCACTTGAAATTATGATGCAAAGGTTTCTCTTGCATTGAA
ACCCTCTTGGATATTACAGTATTTTTAATTGAAAGTCCTAATTCTGTTAAGGAAAGGAGTTGATTAAATTTTAAGGTACCACTGGTATTT
TGGGAGATTATAATCAGTTTGTTTTCAAGATAATAGAAAATAAGGTCCATGAGAATAGAAGTTATGTGATTTCAGTGAGTTGATGTGTAC
AGCATGGCTGTGCTCCATCTGATTTACCCCATTCTTAAGTTCTGAGAGTATGTTCTCAAGGAAGATTTAACTCTCTTTGGTTTTAAATTA
CTTTTTAACCAGCCTAATAAATAAGTCTTACTACTTTTCATAATATTTCATAATAGTTAAAAGTAGGTGTTTTTTTCGTGCTCAATTTGG
CACTCAAAATAATGTTCATTATGGAAGTTTGGTAATACTGAGCAAGCCTGTGGAATTTTCTTTATGAAAAATGATTTTAGCCTTTGCAAA
TGTTAACCATGTGAAACACATTTTCAGTATAAGTATGCGTTACAGGGTTTGATACTTTCCTGCACTTAGGTTTGTCCTATTCTTCATTTA
TTCATACTAGGATAGAAAATTTTGGAATCAGAAAATAGATCCAGTGTTTAGCTACATACAATCTAGTACAAGTGAATTTTTATTCTTAAA
CATAGGTGTGTTGGCTCTTTTTTTAAAAGATGCGCTCTACCTGAAAAGGAAATTGGATTTTAGAACTGGATGTGGTGCAGTGAAGTATTT
TAGGCCCAGGTCTGTGTACACATTTTATAGAAGAATGAAGTACTCTGAAGTATTTTGGTTGCCTTTTCATTTCAACTGTGTTTTGAATTT
GTCAGATCACACATATATTGTGTTATTGGGCGCTGTGGTATCTTTTATAAAACCTCTTGCTTGTGTGCAAAAGTTCCTAAAAGGAAACAC
AAGTAATGCCTATCCATTACTAGCATGCTATGCTGCATGCTTTACTGCCATTGCTGTATGCTTTACTGTCTTTGTAAAAATCCCCCTCTC
CCCTTTTCTGGTAACTGGAAAAGCATGCTAAAAATAGTCTTATATTTTCACCCCATAAATGCAGAATCAGTAATTCCTTGGCTTAAAGCT
CTTATATAATCAATATTATTGGTGGTAAATACCAAGTTTGGTATCTCATAGCTATCTTTTTTTAAAGAAATTAAGTTCTTGAAAATTTAG
CCAAATCCCGTTTTATGGGAATGCTCTTTAGAATTCATTTTGTTCAGCCCCTTTGTTCTATGGTTGAGAAATCTGAGGCCTTACGAAGGT
TAAGAGAACTTTCCCCGTGTCTCACAGGTAGGTAGAGGCAGAGCTGGAACTAGATATCTGGTCTGTTGACTCTAGCTCAGTGTCTTCTGG
TAACTGTTGAAAATTGTCTTAGTTTGAGAGATGGCTGAAATAATGAACATAAAATGCTATTTATAATAACAAGTATATGTGAAATTTCTT
ATTGTAAGACTACTACCGGCTTACTGTTGAATAGTTTGGTTATAGTGTTTAGGCTAGAAATGCCTCCCACATTGGTAATAAACATTACAA
AATACAATGTATTTTTAGGTAGGCATTTTATAAAATGCATTATGCCATGGTTGCTTTTGAGATAGATTGTAGTCTGGGTAGCATCTTTAA
AATGTATGTGGGCTTAACTGTTGTTCATATCAGGAGATGCTCTGATTGTATAGGTGAGACTCTGTTTCTGTTATTTTTAATTGCTGTATG
AAATGTGATCAGATTATTTTACTACCAACAGTTATAGTTTGAAAGTCCAACTGTATTAATTGACTGATAATATGATAATATAGAGATTAA
ATTGTTTGTCTTCATTCCTTATATGTTTAGAAGTTTTTGCTTTGTCTGCCTGCTTACTTGTATATGTAAGCATGAGGGAAATACACTGTT
GCTAATACTGAAATTACAATCAAGTAACTAAGGCCTTGAGTTCATATGTGACACTGAATGCACTAGCTTCCTTCGTTCTATAACTAATGT
ACCTTAACTTCCCCCATTCTTATATTTACAAGAAGCTAAGTCATTATGTTCTGAGTGTGTGGTATGTTCCCTTAAAAAAAAATGACACTT
GGAAGAAAAATGTATGAAATTCAGAAATTCCGATCAAAGAAAAGTAATTCTTTCTTTTTTTTTTTGAGACAGAGTCTTGCTTTGTTGCCC
AGGCTGGAGGGCAGTGGTGTGATCTCACCTCACTGCAGCTTCCGCCTCCTGGGTTCAAGTGATTCTCATGGCTCAGCCGCCTGAGTAGCT
GGGATTACAGGTGTGAGCCAACAAGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGTCAGGCTGGGCTCAAA
CTCCTGAATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTGCCGCACCCAGCCAAGAAAAATAATACTCTTAAAT
ACTTAGATGTTCACCTAAAGTTGATATTATTTGGTATGGGAATTACTTTTGAACTGTAATCTTTCAGATTACACCACTTTGAAAACAAGT
TTTAACAGTAGGGTAAAAATATAGTTTTTGAGGGTATTCCCAACTTGTGATCTTCTACCACTTTAGAGACATTCAAGTAATAGTTTTCTT
AGAGCTTTGCACATTCCTATTCACTGAGATTTTAAAAATTTCACCTTTATTCGAGGGAAGGATCAATGCTTATTACCATTTGGAAAAACG
AAGATCAGAAGGTAAATGATCTTTATTTTCTAGCTTTAAAGGGAAATTAAACCATTCATGAATAAACTTTAAAAATGTGAAGTGTCCTTT
TCCTTTTCACAATACAAAAAAAATTTCAACAGATTGTGTGGTTTGTGCATTTATATCCTGTTAAGCATTAATAGCTAATCACTGGGACTT
GAATTCTGATGGCAGATAGTCTCTTGCTTAGTGAGATGGAGTTAACTATTTTTTAGTAGGAAGTGAGAACAGCTGATTTTCATGCCACGT
TTCATAGCCCCACTTTTGGTAGACTACCACCACGCTTCTTCGCGTAAGCAGTGGCATCTTGGGAATGAATGCCCAGCCGCTCGTGGGTTG
GTGCAAAGAAGTATAAACATATATCACTAAGGAAAAAGAAAGTTTGTCTTGCCCTTCTGACACAGTGTGTGCACTTCAGGCAATTTTTGG
AAAATATAAAAAATTCCAAATTCTGCCTTTCAGCAGCATCAATTGCTAGGAACATTTCATTCATTTCCCTGTAATATTAATGTTCTTTAA
GCATAATCACTAATTATAAGTTGTATCCTATTTTTTTCCAGCTTAATTTCTGTGGTTTATTGAAAACCAAGTATAAATGTGACTAAAAGC
ATTTTGCTTTGTTTTTATAGTTAACTTTCTTAAGGTTATGGACATTTTATAATGTAACATTTGATTGGCCTGGCCTCTTGACAATTCCCT
TCTAGTTATGCATATCCTCCTGTTGCCACATTTCTTGTTTTAAAACTCAGTTTCTTGTTTTCCAGTTGTTGCTATGTATAACACCCATCT
TGAAAGAGAGTATATAGGAAGTTATTCAGATAACTTTTGTAGTAGTGATATTCAACTATAGCAGTACCTTAACTCATGATGAGCTTAGGA
ACATAAAAGATAATTGTTGCTTGAATAGCACCCCCAGAGATACTGACCTAATTGGTCTGGGGTGGAGATCTGGCATGGTAGTTTTTTTCA
AGCTCCAATCATCGGCCAGACAGTTGCTTTATGTAGGTTTTTAAATGCCAAAGGCAGATATGAAGTAGATTTAATTAAGACTTGACTTCA
GCAATACAGGGGAACTTAAAATACTTATTTTTCTTTAAACTGCAGGAGTCACTGTTAGGTATTGCTTAAAAAAAATTGCATAAAAGCTTT
GCTTGTCAAGTTAGGATTGCTGGAATACCACTAAAGATTTTTGACTTGTGAATAAATGAGCTGTCATCGCAAAAAGGCGATTTGAGAAAT
GTGGGCTTCAGTATTAATTGCCATTTTGCTGACACCCAGTGTACCTACCTACCTGAGAAATTTATTTTGTCCATCATGTATTTCTCAAAG
CAAAAGGTGGTTTTCAAGTATAATGTCGTTTTCAACATGCTTATTACTTAGTTTTACGTCAGCTCATTTCATCATCATTGATAACTTGTG
AAATACTTATCTCCATCCTATGGAATAGGGGAGACGGGTTTAGACAGGTTCAATTAGCTCAAGTCTACACAGCTGAAGTAGCAGAGAAAG
TGGGATCTAGATGGTCTGATCCTAGTGATCTACCATATGAAGGACATAGTTTGTGTCCTGGTCCAAGTCAAATATTGACTCCTCACAAAC
AGTAAGTATGGCAATTTTGTGATGCCTTTGATTCCACTTTACATGGAGTACTATTATTTGTGAAATGTCTTTAAGATTTTTGGTCTTAAA
TTTTTGAAGACTGCTTTCCCCCTTTATCTCCCAGAAAATTGAGAAGAAGTAAACTCCTGCCCACTAACAATCTCAGTCCGTGAACAAAAC
CAACATGAACATTCCTAAACAAGAGTGTGTGTTACTCTAAGAAGAAGGCTATAGAATTTATGGAAATGGCTTATGTAACCTACAAGACTG
GAGAACAGAATGTGACTGGCCTTTTCTAATGGTCCTTTAAGATTTAATGATTAAAGCAAGAGTTTTTTATAATTGACTTTGTGGTCTAAA
TTCTTGATACTGTTTATAATTCTACAAAGAACAAAAATTGTTATGTACTATAGGCACTTAAGAACCCTGAGGAAAAATAATACAATGTGT
GTGTGTGAGAGAGAGAGTGAGTTACTGACATTGTTCCAAAAAAAAAAAAAAAAAAAAAAAAAATGTGGAGGGTTGAAATGGTAAGGAATT
GGAATCTTTTGTATTTTCGAGCAATAAGAATTCCTATTCTTGTTTCAAATAGAGGTTTGTTAGGAATTACAGTTGTGGGGAGCAAACTTT
CTTTTTTGTGCTGTTTTAATTCAAAATGTATATCCTTAATTGTATATAATATGTAGATAAATATATGAGGGTATTAAGCTACTTTGAATT

>4584_4584_6_ANKRD12-VAPA_ANKRD12_chr18_9221997_ENST00000400020_VAPA_chr18_9931807_ENST00000400000_length(amino acids)=519AA_BP=1
MNSCKMPKSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEK
KKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDV
KQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPV
DVAETEELELLLKREVPLSDDDESYTGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEK
SKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD12-VAPA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD12-VAPA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD12-VAPA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource