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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LNPEP-FLT4 (FusionGDB2 ID:45864)

Fusion Gene Summary for LNPEP-FLT4

Fusion gene summary

Fusion gene information	Fusion gene name: LNPEP-FLT4
	Fusion gene ID: 45864
		Hgene	Tgene
	Gene symbol	LNPEP	FLT4
	Gene ID	4012	2324
	Gene name	leucyl and cystinyl aminopeptidase	fms related receptor tyrosine kinase 4
	Synonyms	CAP\|IRAP\|P-LAP\|PLAP	CHTD7\|FLT-4\|FLT41\|LMPH1A\|LMPHM1\|PCL\|VEGFR-3\|VEGFR3
	Cytomap	5q15	5q35.3
	Type of gene	protein-coding	protein-coding
	Description	leucyl-cystinyl aminopeptidaseAT (4) receptorangiotensin IV receptorcystinyl aminopeptidaseinsulin-regulated aminopeptidaseinsulin-regulated membrane aminopeptidaseinsulin-responsive aminopeptidaseotaseoxytocinaseplacental leucine aminopeptidase	vascular endothelial growth factor receptor 3Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4VEGF receptor-3fms related tyrosine kinase 4fms-like tyrosine kinase 4primary congenital lymphedematyrosine-protein kinase receptor FLT4
	Modification date	20200313	20200313
	UniProtAcc	Q9UIQ6	P35916
	Ensembl transtripts involved in fusion gene	ENST00000395784, ENST00000231368, ENST00000395770,	ENST00000261937, ENST00000393347, ENST00000502649, ENST00000424276,
Fusion gene scores	* DoF score	9 X 8 X 6=432	5 X 4 X 3=60
	# samples	10	5
	** MAII score	log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LNPEP [Title/Abstract] AND FLT4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LNPEP(96271878)-FLT4(180048904), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FLT4	GO:0018108	peptidyl-tyrosine phosphorylation	7898938
Tgene	FLT4	GO:0035924	cellular response to vascular endothelial growth factor stimulus	9435229
Tgene	FLT4	GO:0038084	vascular endothelial growth factor signaling pathway	23878260
Tgene	FLT4	GO:0046777	protein autophosphorylation	7675451\|9435229\|23878260
Tgene	FLT4	GO:0048010	vascular endothelial growth factor receptor signaling pathway	9012504

Fusion gene breakpoints across LNPEP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FLT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-D3-A8GN-06A	LNPEP	chr5	96271878	-	FLT4	chr5	180048904	-
ChimerDB4	SKCM	TCGA-D3-A8GN-06A	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-

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Fusion Gene ORF analysis for LNPEP-FLT4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000395784	ENST00000261937	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
3UTR-3CDS	ENST00000395784	ENST00000393347	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
3UTR-3CDS	ENST00000395784	ENST00000502649	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
3UTR-5UTR	ENST00000395784	ENST00000424276	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
5CDS-5UTR	ENST00000231368	ENST00000424276	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
In-frame	ENST00000231368	ENST00000261937	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
In-frame	ENST00000231368	ENST00000393347	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
In-frame	ENST00000231368	ENST00000502649	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
intron-3CDS	ENST00000395770	ENST00000261937	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
intron-3CDS	ENST00000395770	ENST00000393347	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
intron-3CDS	ENST00000395770	ENST00000502649	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-
intron-5UTR	ENST00000395770	ENST00000424276	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000231368	LNPEP	chr5	96271878	+	ENST00000261937	FLT4	chr5	180048904	-	4832	711	491	3145	884
ENST00000231368	LNPEP	chr5	96271878	+	ENST00000393347	FLT4	chr5	180048904	-	3267	711	491	2950	819
ENST00000231368	LNPEP	chr5	96271878	+	ENST00000502649	FLT4	chr5	180048904	-	3139	711	491	2974	827

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000231368	ENST00000261937	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-	0.008007697	0.9919923
ENST00000231368	ENST00000393347	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-	0.015719682	0.98428035
ENST00000231368	ENST00000502649	LNPEP	chr5	96271878	+	FLT4	chr5	180048904	-	0.014945247	0.98505473

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Fusion Genomic Features for LNPEP-FLT4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LNPEP-FLT4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:96271878/chr5:180048904)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LNPEP Q9UIQ6	FLT4 P35916
FUNCTION: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269\|PubMed:11389728, ECO:0000269\|PubMed:11707427, ECO:0000269\|PubMed:1731608}.	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269\|PubMed:11532940, ECO:0000269\|PubMed:15102829, ECO:0000269\|PubMed:15474514, ECO:0000269\|PubMed:16076871, ECO:0000269\|PubMed:16452200, ECO:0000269\|PubMed:17210781, ECO:0000269\|PubMed:19610651, ECO:0000269\|PubMed:19779139, ECO:0000269\|PubMed:20224550, ECO:0000269\|PubMed:20431062, ECO:0000269\|PubMed:20445537, ECO:0000269\|PubMed:21273538, ECO:0000269\|PubMed:7675451, ECO:0000269\|PubMed:8700872, ECO:0000269\|PubMed:9435229}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

555_671

552

1364.0

Domain

Note=Ig-like C2-type 6

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

678_764

552

1364.0

Domain

Note=Ig-like C2-type 7

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

845_1173

552

1364.0

Domain

Protein kinase

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

555_671

552

1299.0

Domain

Note=Ig-like C2-type 6

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

678_764

552

1299.0

Domain

Note=Ig-like C2-type 7

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

845_1173

552

1299.0

Domain

Protein kinase

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

851_859

552

1364.0

Nucleotide binding

ATP

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

851_859

552

1299.0

Nucleotide binding

ATP

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

797_1363

552

1364.0

Topological domain

Cytoplasmic

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

797_1363

552

1299.0

Topological domain

Cytoplasmic

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

776_796

552

1364.0

Transmembrane

Helical

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

776_796

552

1299.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000231368

53_54

1026.0

Motif

Dileucine internalization motif

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000231368

76_77

1026.0

Motif

Dileucine internalization motif

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000395770

53_54

1012.0

Motif

Dileucine internalization motif

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000395770

76_77

1012.0

Motif

Dileucine internalization motif

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000231368

428_432

1026.0

Region

Substrate binding

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000231368

96_101

1026.0

Region

Note=Tankyrase binding

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000395770

428_432

1012.0

Region

Substrate binding

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000395770

96_101

1012.0

Region

Note=Tankyrase binding

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000231368

132_1025

1026.0

Topological domain

Extracellular

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000231368

1_110

1026.0

Topological domain

Cytoplasmic

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000395770

132_1025

1012.0

Topological domain

Extracellular

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000395770

1_110

1012.0

Topological domain

Cytoplasmic

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000231368

111_131

1026.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

LNPEP

chr5:96271878

chr5:180048904

ENST00000395770

111_131

1012.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

151_213

552

1364.0

Domain

Note=Ig-like C2-type 2

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

219_326

552

1364.0

Domain

Note=Ig-like C2-type 3

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

30_127

552

1364.0

Domain

Note=Ig-like C2-type 1

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

331_415

552

1364.0

Domain

Note=Ig-like C2-type 4

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

422_552

552

1364.0

Domain

Note=Ig-like C2-type 5

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

151_213

552

1299.0

Domain

Note=Ig-like C2-type 2

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

219_326

552

1299.0

Domain

Note=Ig-like C2-type 3

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

30_127

552

1299.0

Domain

Note=Ig-like C2-type 1

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

331_415

552

1299.0

Domain

Note=Ig-like C2-type 4

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

422_552

552

1299.0

Domain

Note=Ig-like C2-type 5

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000261937

25_775

552

1364.0

Topological domain

Extracellular

Tgene

FLT4

chr5:96271878

chr5:180048904

ENST00000393347

25_775

552

1299.0

Topological domain

Extracellular

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Fusion Gene Sequence for LNPEP-FLT4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>45864_45864_1_LNPEP-FLT4_LNPEP_chr5_96271878_ENST00000231368_FLT4_chr5_180048904_ENST00000261937_length(transcript)=4832nt_BP=711nt
TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG
CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA
TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA
TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT
CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC
CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA
AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG
CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGCCATCCCCG
ACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACG
AGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCATCTGT
TCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCG
AGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGG
AAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACG
CGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCC
AGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGG
AAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCA
TCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGG
AGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGCTACGGCGCCT
TCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCA
CGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCCTCGGGGCGT
GCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCT
TCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGA
GCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACCTGTGGC
TGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGTGCATCCACA
GAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACC
CCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTG
ACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCC
AGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATCATGCTGAACTGCTGGTCCGGAGACC
CCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCA
TGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACGCTGAGG
ACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGA
CCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGTG
GGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCTTCAGCTGTAAAGGACCTGGCCAGAATG
TGGCTGTGACCAGGGCACACCCTGACTCCCAAGGGAGGCGGCGGCGGCCTGAGCGGGGGGCCCGAGGAGGCCAGGTGTTTTACAACAGCG
AGTATGGGGAGCTGTCGGAGCCAAGCGAGGAGGACCACTGCTCCCCGTCTGCCCGCGTGACTTTCTTCACAGACAACAGCTACTAAGCAG
CATCGGACAAGACCCCCAGCACTTGGGGGTTCAGGCCCGGCAGGGCGGGCAGAGGGCTGGAGGCCCAGGCTGGGAACTCATCTGGTTGAA
CTCTGGTGGCACAGGAGTGTCCTCTTCCCTCTCTGCAGACTTCCCAGCTAGGAAGAGCAGGACTCCAGGCCCAAGGCTCCCGGAATTCCG
TCACCACGACTGGCCAGGGCCACGCTCCAGCTGCCCCGGCCCCTCCCCCTGAGATTCAGATGTCATTTAGTTCAGCATCCGCAGGTGCTG
GTCCCGGGGCCAGCACTTCCATGGGAATGTCTCTTTGGCGACCTCCTTTCATCACACTGGGTGGTGGCCTGGTCCCTGTTTTCCCACGAG
GAATCTGTGGGTCTGGGAGTCACACAGTGTTGGAGGTTAAGGCATACGAGAGCAGAGGTCTCCCAAACGCCCTTTCCTCCTCAGGCACAC
AGCTACTCTCCCCACGAGGGCTGGCTGGCCTCACCCACCCCTGCACAGTTGAAGGGAGGGGCTGTGTTTCCATCTCAAAGAAGGCATTTG
CAGGGTCCTCTTCTGGGCCTGACCAAACAGCCAACTAGCCCCTGGGGTGGCCACCAGTATGACAGTATTATACGCTGGCAACACAGAGGC
AGCCCGCACACCTGCGCCTGGGTGTTGAGAGCCATCCTGCAAGTCTTTTTCAACAGAACTTCACAGACTGTTAGAGCTGCTGAGAAGAAT
TTGCTTTCCGAATTCAGCCTGGAAGGCGCCCAGGGACAGCTGTACTGAGTCTAGATGACTCTGACCCCCGCCCCAGGTCAAGGCCAGCAG
AGCAGTCAGTGCCTCTGGAGAAGGCCCTTGCTCTCCCACCTGGCCCAGACTCCGAGGAGCCTGGGTCTGGAGCTGCCGGTCTGGTTCTTC
CCTTTAGAGCCCGGATCTGCCACCTGCGGCCCCTCCCAAGCCGTGAACCAGCTCATGAGAGATGAACACTGTGGGATCCACTCAGGAAGG
CTCGGGGCTGGCACAAAGGACCACCCAGCATTGCCCTGTGCCACCCAGCACTCAGTGGACATTCTGGGGACCTGCCTTCAGCCTTTTCCT
GCCCTGTGCCTGACATCAGCACCCTGGCTGGTCAGAATGCCGCCCTCCCAGAGGAGCAGCCGAGAGATCCCCTGAAGGCTGGAGGCATTC
TGCTCAGGACCCCTATCCCAGCTCACAGTGCCCAACCATCTCACCAGGAGAAAGAGCCACATCCCCACGTTAGGACCACGGAGACTGACC
ACCACCCTGACCCCCCAAACCCACGCACCAGACGCTTGCAGGACAGGCGCCGCGCAGCGGGCAGGGGCTTGCCCGGCCGACCCTCCCCTC
CCCACCTCCCCCACTGCGCGTTACTCCAGGATATGCCGAGTGCACGTATAAGGTCATCTTCGTCGTCCCCGTGGACCTCCCCCTTCCTCT
GCACGTCGTCCAACGTGGGACTGGCGTGTCAGGCTTCCCTGGGAGGATCTGGAGGTTGTTCTCTGCAGAGAACCAGCCTGGCTCCTGGCG
CGCACCTCTGCTCCCTTCTCCTCACTACCCACCCACGCATGTACCGGGAAAAAAACTACTATGCCCTTCTAGACCATGTTCTGAGAAAAG

>45864_45864_1_LNPEP-FLT4_LNPEP_chr5_96271878_ENST00000231368_FLT4_chr5_180048904_ENST00000261937_length(amino acids)=884AA_BP=73
MCFSLLLPSLFLQLPRKPGTAERRRPSRHLPGSPWRPRWACSVSWAASALGVGSSGAPAVRSRGGGKMEPFTNAIPDGFTIESKPSEELL
EGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRR
SHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCS
VCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWE
FPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEF
CKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSF
QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFS
LGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSF
SQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIES

--------------------------------------------------------------
>45864_45864_2_LNPEP-FLT4_LNPEP_chr5_96271878_ENST00000231368_FLT4_chr5_180048904_ENST00000393347_length(transcript)=3267nt_BP=711nt
TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG
CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA
TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA
TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT
CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC
CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA
AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG
CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGCCATCCCCG
ACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACG
AGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCATCTGT
TCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCG
AGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGG
AAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACG
CGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCC
AGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGG
AAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCA
TCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGG
AGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGCTACGGCGCCT
TCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCA
CGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCCTCGGGGCGT
GCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCT
TCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGA
GCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACCTGTGGC
TGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGTGCATCCACA
GAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACC
CCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTG
ACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCC
AGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATCATGCTGAACTGCTGGTCCGGAGACC
CCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCA
TGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACGCTGAGG
ACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGA
CCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGTG
GGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCTTCAGGTAGCTGAAGCAGAGAGAGAGAA
GGCAGCATACGTCAGCATTTTCTTCTCTGCACTTATAAGAAAGATCAAAGACTTTAAGACTTTCGCTATTTCTTCTACTGCTATCTACTA
CAAACTTCAAAGAGGAACCAGGAGGACAAGAGGAGCATGAAAGTGGACAAGGAGTGTGACCACTGAAGCACCACAGGGAGGGGTTAGGCC
TCCGGATGACTGCGGGCAGGCCTGGATAATATCCAGCCTCCCACAAGAAGCTGGTGGAGCAGAGTGTTCCCTGACTCCTCCAAGGAAAGG

>45864_45864_2_LNPEP-FLT4_LNPEP_chr5_96271878_ENST00000231368_FLT4_chr5_180048904_ENST00000393347_length(amino acids)=819AA_BP=73
MCFSLLLPSLFLQLPRKPGTAERRRPSRHLPGSPWRPRWACSVSWAASALGVGSSGAPAVRSRGGGKMEPFTNAIPDGFTIESKPSEELL
EGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRR
SHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCS
VCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWE
FPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEF
CKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSF
QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFS
LGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSF
SQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIES

--------------------------------------------------------------
>45864_45864_3_LNPEP-FLT4_LNPEP_chr5_96271878_ENST00000231368_FLT4_chr5_180048904_ENST00000502649_length(transcript)=3139nt_BP=711nt
TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG
CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA
TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA
TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT
CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC
CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA
AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG
CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGCCATCCCCG
ACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACG
AGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCATCTGT
TCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCG
AGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGG
AAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACG
CGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCC
AGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGG
AAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCA
TCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGG
AGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGCTACGGCGCCT
TCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCA
CGGCCAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCCTCGGGGCGT
GCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCT
TCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGA
GCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACCTGTGGC
TGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGTGCATCCACA
GAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACC
CCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTG
ACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCC
AGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATCATGCTGAACTGCTGGTCCGGAGACC
CCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCA
TGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACGCTGAGG
ACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGA
CCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGTG
GGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCTTCAGAGGAACCAGGAGGACAAGAGGAG
CATGAAAGTGGACAAGGAGTGTGACCACTGAAGCACCACAGGGAGGGGTTAGGCCTCCGGATGACTGCGGGCAGGCCTGGATAATATCCA

>45864_45864_3_LNPEP-FLT4_LNPEP_chr5_96271878_ENST00000231368_FLT4_chr5_180048904_ENST00000502649_length(amino acids)=827AA_BP=73
MCFSLLLPSLFLQLPRKPGTAERRRPSRHLPGSPWRPRWACSVSWAASALGVGSSGAPAVRSRGGGKMEPFTNAIPDGFTIESKPSEELL
EGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRR
SHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCS
VCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWE
FPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEF
CKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSF
QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFS
LGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSF
SQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIES

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LNPEP-FLT4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LNPEP-FLT4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LNPEP-FLT4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source