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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LNPEP-GPBP1 (FusionGDB2 ID:45865)

Fusion Gene Summary for LNPEP-GPBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LNPEP-GPBP1
Fusion gene ID: 45865
HgeneTgene
Gene symbol

LNPEP

GPBP1

Gene ID

4012

65056

Gene nameleucyl and cystinyl aminopeptidaseGC-rich promoter binding protein 1
SynonymsCAP|IRAP|P-LAP|PLAPGPBP|SSH6|VASCULIN
Cytomap

5q15

5q11.2

Type of geneprotein-codingprotein-coding
Descriptionleucyl-cystinyl aminopeptidaseAT (4) receptorangiotensin IV receptorcystinyl aminopeptidaseinsulin-regulated aminopeptidaseinsulin-regulated membrane aminopeptidaseinsulin-responsive aminopeptidaseotaseoxytocinaseplacental leucine aminopeptidasevasculinvascular wall-linked protein
Modification date2020031320200327
UniProtAcc

Q9UIQ6

Q9HC44

Ensembl transtripts involved in fusion geneENST00000395784, ENST00000231368, 
ENST00000395770, 		ENST00000264779, 
ENST00000424459, ENST00000454432, 
ENST00000506184, ENST00000511209, 
ENST00000514387, ENST00000538707, 
Fusion gene scores* DoF score9 X 8 X 6=43217 X 16 X 9=2448
# samples 1017
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/2448*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LNPEP [Title/Abstract] AND GPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLNPEP(96271878)-GPBP1(56545281), # samples:3
Anticipated loss of major functional domain due to fusion event.LNPEP-GPBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LNPEP-GPBP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LNPEP-GPBP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LNPEP-GPBP1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LNPEP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GPBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KICHTCGA-KM-8443-01ALNPEPchr5

96271878

+GPBP1chr5

56545236

+
ChimerDB4KICHTCGA-KM-8443-01ALNPEPchr5

96271878

-GPBP1chr5

56545281

+
ChimerDB4KICHTCGA-KM-8443-01ALNPEPchr5

96271878

+GPBP1chr5

56545281

+
ChimerDB4KICHTCGA-KM-8443-01ALNPEPchr5

96271878

+GPBP1chr5

56545284

+
ChimerDB4KICHTCGA-KM-8443-01ALNPEPchr5

96271878

+GPBP1chr5

56557007

+


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Fusion Gene ORF analysis for LNPEP-GPBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000395784ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545281

+
3UTR-3CDSENST00000395784ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545284

+
3UTR-3CDSENST00000395784ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56557007

+
3UTR-3CDSENST00000395784ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545236

+
3UTR-3CDSENST00000395784ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545281

+
3UTR-3CDSENST00000395784ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545284

+
3UTR-3CDSENST00000395784ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56557007

+
3UTR-3CDSENST00000395784ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545236

+
3UTR-3CDSENST00000395784ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545281

+
3UTR-3CDSENST00000395784ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545284

+
3UTR-3CDSENST00000395784ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56557007

+
3UTR-3CDSENST00000395784ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545236

+
3UTR-3CDSENST00000395784ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545281

+
3UTR-3CDSENST00000395784ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545284

+
3UTR-3CDSENST00000395784ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56557007

+
3UTR-3CDSENST00000395784ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545281

+
3UTR-3CDSENST00000395784ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545284

+
3UTR-3CDSENST00000395784ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56557007

+
3UTR-3CDSENST00000395784ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545236

+
3UTR-3CDSENST00000395784ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545281

+
3UTR-3CDSENST00000395784ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545284

+
3UTR-3CDSENST00000395784ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56557007

+
3UTR-3CDSENST00000395784ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545281

+
3UTR-3CDSENST00000395784ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545284

+
3UTR-3CDSENST00000395784ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56557007

+
3UTR-intronENST00000395784ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545236

+
3UTR-intronENST00000395784ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545236

+
3UTR-intronENST00000395784ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545236

+
5CDS-intronENST00000231368ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545236

+
5CDS-intronENST00000231368ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545236

+
5CDS-intronENST00000231368ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545236

+
Frame-shiftENST00000231368ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545281

+
Frame-shiftENST00000231368ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545284

+
Frame-shiftENST00000231368ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56557007

+
Frame-shiftENST00000231368ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545236

+
Frame-shiftENST00000231368ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545281

+
Frame-shiftENST00000231368ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545284

+
Frame-shiftENST00000231368ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56557007

+
Frame-shiftENST00000231368ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545236

+
Frame-shiftENST00000231368ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545281

+
Frame-shiftENST00000231368ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545284

+
Frame-shiftENST00000231368ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56557007

+
Frame-shiftENST00000231368ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545236

+
Frame-shiftENST00000231368ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545281

+
Frame-shiftENST00000231368ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545284

+
Frame-shiftENST00000231368ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56557007

+
Frame-shiftENST00000231368ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545281

+
Frame-shiftENST00000231368ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545284

+
Frame-shiftENST00000231368ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56557007

+
Frame-shiftENST00000231368ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545236

+
Frame-shiftENST00000231368ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545281

+
Frame-shiftENST00000231368ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545284

+
Frame-shiftENST00000231368ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56557007

+
Frame-shiftENST00000231368ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545281

+
Frame-shiftENST00000231368ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545284

+
Frame-shiftENST00000231368ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-3CDSENST00000395770ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545281

+
intron-3CDSENST00000395770ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545284

+
intron-3CDSENST00000395770ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-3CDSENST00000395770ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545236

+
intron-3CDSENST00000395770ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545281

+
intron-3CDSENST00000395770ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56545284

+
intron-3CDSENST00000395770ENST00000424459LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-3CDSENST00000395770ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545236

+
intron-3CDSENST00000395770ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545281

+
intron-3CDSENST00000395770ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56545284

+
intron-3CDSENST00000395770ENST00000454432LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-3CDSENST00000395770ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545236

+
intron-3CDSENST00000395770ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545281

+
intron-3CDSENST00000395770ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56545284

+
intron-3CDSENST00000395770ENST00000506184LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-3CDSENST00000395770ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545281

+
intron-3CDSENST00000395770ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545284

+
intron-3CDSENST00000395770ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-3CDSENST00000395770ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545236

+
intron-3CDSENST00000395770ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545281

+
intron-3CDSENST00000395770ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56545284

+
intron-3CDSENST00000395770ENST00000514387LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-3CDSENST00000395770ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545281

+
intron-3CDSENST00000395770ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545284

+
intron-3CDSENST00000395770ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56557007

+
intron-intronENST00000395770ENST00000264779LNPEPchr5

96271878

+GPBP1chr5

56545236

+
intron-intronENST00000395770ENST00000511209LNPEPchr5

96271878

+GPBP1chr5

56545236

+
intron-intronENST00000395770ENST00000538707LNPEPchr5

96271878

+GPBP1chr5

56545236

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LNPEP-GPBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LNPEPchr596271878+GPBP1chr556557006+0.0001028750.9998971
LNPEPchr596271878+GPBP1chr556545280+4.46E-060.9999956
LNPEPchr596271878+GPBP1chr556545235+8.23E-080.9999999
LNPEPchr596271878+GPBP1chr556557006+0.0001028750.9998971
LNPEPchr596271878+GPBP1chr556545280+4.46E-060.9999956
LNPEPchr596271878+GPBP1chr556545235+8.23E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LNPEP-GPBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:96271878/:56545281)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LNPEP

Q9UIQ6

GPBP1

Q9HC44

FUNCTION: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.FUNCTION: Possible transcription factor. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LNPEP-GPBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LNPEP-GPBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LNPEP-GPBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LNPEP-GPBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource