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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LNPEP-PPIP5K2 (FusionGDB2 ID:45868)

Fusion Gene Summary for LNPEP-PPIP5K2

check button Fusion gene summary
Fusion gene informationFusion gene name: LNPEP-PPIP5K2
Fusion gene ID: 45868
HgeneTgene
Gene symbol

LNPEP

PPIP5K2

Gene ID

4012

23262

Gene nameleucyl and cystinyl aminopeptidasediphosphoinositol pentakisphosphate kinase 2
SynonymsCAP|IRAP|P-LAP|PLAPCFAP160|DFNB100|HISPPD1|IP7K2|VIP2
Cytomap

5q15

5q21.1

Type of geneprotein-codingprotein-coding
Descriptionleucyl-cystinyl aminopeptidaseAT (4) receptorangiotensin IV receptorcystinyl aminopeptidaseinsulin-regulated aminopeptidaseinsulin-regulated membrane aminopeptidaseinsulin-responsive aminopeptidaseotaseoxytocinaseplacental leucine aminopeptidaseinositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2VIP1 homolog 2deafness, autosomal recessive 100histidine acid phosphatase domain-containing protein 1inositol heptaphosphate kinase 2insP6 and PP-IP5 kinase 2
Modification date2020031320200313
UniProtAcc

Q9UIQ6

.
Ensembl transtripts involved in fusion geneENST00000231368, ENST00000395770, 
ENST00000395784, 		ENST00000414217, 
ENST00000513500, ENST00000321521, 
ENST00000358359, 
Fusion gene scores* DoF score9 X 8 X 6=4325 X 6 X 3=90
# samples 105
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LNPEP [Title/Abstract] AND PPIP5K2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLNPEP(96322374)-PPIP5K2(102537222), # samples:2
LNPEP(96322374)-PPIP5K2(102537223), # samples:2
Anticipated loss of major functional domain due to fusion event.LNPEP-PPIP5K2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LNPEP-PPIP5K2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LNPEP-PPIP5K2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LNPEP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPIP5K2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XK-AAJ3-01ALNPEPchr5

96322374

-PPIP5K2chr5

102537223

+
ChimerDB4PRADTCGA-XK-AAJ3LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
ChimerDB4PRADTCGA-XK-AAJ3LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+


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Fusion Gene ORF analysis for LNPEP-PPIP5K2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000231368ENST00000414217LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
5CDS-3UTRENST00000231368ENST00000414217LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
5CDS-3UTRENST00000231368ENST00000513500LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
5CDS-3UTRENST00000231368ENST00000513500LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
5CDS-3UTRENST00000395770ENST00000414217LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
5CDS-3UTRENST00000395770ENST00000414217LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
5CDS-3UTRENST00000395770ENST00000513500LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
5CDS-3UTRENST00000395770ENST00000513500LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
Frame-shiftENST00000231368ENST00000321521LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
Frame-shiftENST00000231368ENST00000321521LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
Frame-shiftENST00000395770ENST00000321521LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
Frame-shiftENST00000395770ENST00000321521LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
In-frameENST00000231368ENST00000358359LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
In-frameENST00000231368ENST00000358359LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
In-frameENST00000395770ENST00000358359LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
In-frameENST00000395770ENST00000358359LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
intron-3CDSENST00000395784ENST00000321521LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
intron-3CDSENST00000395784ENST00000321521LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
intron-3CDSENST00000395784ENST00000358359LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
intron-3CDSENST00000395784ENST00000358359LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
intron-3UTRENST00000395784ENST00000414217LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
intron-3UTRENST00000395784ENST00000414217LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+
intron-3UTRENST00000395784ENST00000513500LNPEPchr5

96322374

+PPIP5K2chr5

102537222

+
intron-3UTRENST00000395784ENST00000513500LNPEPchr5

96322374

+PPIP5K2chr5

102537223

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000231368LNPEPchr596322374+ENST00000358359PPIP5K2chr5102537222+350818234911882463
ENST00000395770LNPEPchr596322374+ENST00000358359PPIP5K2chr5102537222+312314382291497422
ENST00000231368LNPEPchr596322374+ENST00000358359PPIP5K2chr5102537223+350818234911882463
ENST00000395770LNPEPchr596322374+ENST00000358359PPIP5K2chr5102537223+312314382291497422

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000231368ENST00000358359LNPEPchr596322374+PPIP5K2chr5102537222+0.0001301390.9998698
ENST00000395770ENST00000358359LNPEPchr596322374+PPIP5K2chr5102537222+0.0003424030.99965763
ENST00000231368ENST00000358359LNPEPchr596322374+PPIP5K2chr5102537223+0.0001301390.9998698
ENST00000395770ENST00000358359LNPEPchr596322374+PPIP5K2chr5102537223+0.0003424030.99965763

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Fusion Genomic Features for LNPEP-PPIP5K2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LNPEPchr596322374+PPIP5K2chr5102537222+1.45E-070.9999999
LNPEPchr596322374+PPIP5K2chr5102537222+1.45E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LNPEP-PPIP5K2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:96322374/chr5:102537222)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LNPEP

Q9UIQ6

.
FUNCTION: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269|PubMed:11389728, ECO:0000269|PubMed:11707427, ECO:0000269|PubMed:1731608}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLNPEPchr5:96322374chr5:102537222ENST00000231368+41853_543771026.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537222ENST00000231368+41876_773771026.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537222ENST00000395770+41853_543631012.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537222ENST00000395770+41876_773631012.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537223ENST00000231368+41853_543771026.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537223ENST00000231368+41876_773771026.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537223ENST00000395770+41853_543631012.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537223ENST00000395770+41876_773631012.0MotifDileucine internalization motif
HgeneLNPEPchr5:96322374chr5:102537222ENST00000231368+41896_1013771026.0RegionNote=Tankyrase binding
HgeneLNPEPchr5:96322374chr5:102537222ENST00000395770+41896_1013631012.0RegionNote=Tankyrase binding
HgeneLNPEPchr5:96322374chr5:102537223ENST00000231368+41896_1013771026.0RegionNote=Tankyrase binding
HgeneLNPEPchr5:96322374chr5:102537223ENST00000395770+41896_1013631012.0RegionNote=Tankyrase binding
HgeneLNPEPchr5:96322374chr5:102537222ENST00000231368+4181_1103771026.0Topological domainCytoplasmic
HgeneLNPEPchr5:96322374chr5:102537222ENST00000395770+4181_1103631012.0Topological domainCytoplasmic
HgeneLNPEPchr5:96322374chr5:102537223ENST00000231368+4181_1103771026.0Topological domainCytoplasmic
HgeneLNPEPchr5:96322374chr5:102537223ENST00000395770+4181_1103631012.0Topological domainCytoplasmic
HgeneLNPEPchr5:96322374chr5:102537222ENST00000231368+418111_1313771026.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLNPEPchr5:96322374chr5:102537222ENST00000395770+418111_1313631012.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLNPEPchr5:96322374chr5:102537223ENST00000231368+418111_1313771026.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneLNPEPchr5:96322374chr5:102537223ENST00000395770+418111_1313631012.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLNPEPchr5:96322374chr5:102537222ENST00000231368+418428_4323771026.0RegionSubstrate binding
HgeneLNPEPchr5:96322374chr5:102537222ENST00000395770+418428_4323631012.0RegionSubstrate binding
HgeneLNPEPchr5:96322374chr5:102537223ENST00000231368+418428_4323771026.0RegionSubstrate binding
HgeneLNPEPchr5:96322374chr5:102537223ENST00000395770+418428_4323631012.0RegionSubstrate binding
HgeneLNPEPchr5:96322374chr5:102537222ENST00000231368+418132_10253771026.0Topological domainExtracellular
HgeneLNPEPchr5:96322374chr5:102537222ENST00000395770+418132_10253631012.0Topological domainExtracellular
HgeneLNPEPchr5:96322374chr5:102537223ENST00000231368+418132_10253771026.0Topological domainExtracellular
HgeneLNPEPchr5:96322374chr5:102537223ENST00000395770+418132_10253631012.0Topological domainExtracellular
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003215212830237_24011851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003215212830246_24811851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003215212830321_32311851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003583592931237_24012061244.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003583592931246_24812061244.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003583592931321_32312061244.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000004142172729237_24011851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000004142172729246_24811851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000004142172729321_32311851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003215212830237_24011851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003215212830246_24811851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003215212830321_32311851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003583592931237_24012061244.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003583592931246_24812061244.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003583592931321_32312061244.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000004142172729237_24011851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000004142172729246_24811851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537223ENST000004142172729321_32311851223.0Nucleotide bindingATP
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003215212830213_21411851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003215212830326_32911851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003215212830371_44211851223.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr5:96322374chr5:102537222ENST00000321521283053_5411851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003583592931213_21412061244.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003583592931326_32912061244.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000003583592931371_44212061244.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr5:96322374chr5:102537222ENST00000358359293153_5412061244.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000004142172729213_21411851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000004142172729326_32911851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537222ENST000004142172729371_44211851223.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr5:96322374chr5:102537222ENST00000414217272953_5411851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003215212830213_21411851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003215212830326_32911851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003215212830371_44211851223.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr5:96322374chr5:102537223ENST00000321521283053_5411851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003583592931213_21412061244.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003583592931326_32912061244.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000003583592931371_44212061244.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr5:96322374chr5:102537223ENST00000358359293153_5412061244.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000004142172729213_21411851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000004142172729326_32911851223.0RegionSubstrate binding
TgenePPIP5K2chr5:96322374chr5:102537223ENST000004142172729371_44211851223.0RegionPolyphosphoinositide-binding domain
TgenePPIP5K2chr5:96322374chr5:102537223ENST00000414217272953_5411851223.0RegionSubstrate binding


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Fusion Gene Sequence for LNPEP-PPIP5K2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>45868_45868_1_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000231368_PPIP5K2_chr5_102537222_ENST00000358359_length(transcript)=3508nt_BP=1823nt
TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG
CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA
TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA
TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT
CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC
CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA
AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG
CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGATCGGCTTC
AGCTCCCCAGGAATATGATTGAAAACAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCTTGTTTACATCCTCTAG
AGCCTGATGAGGTGGAATATGAGCCCCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATT
ATGAGTCATCAGCAAAGCTGCTGGGCATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGTTACAGGCAGAGCCCAG
ATGGGGCTTGTTCAGTACCCTCTGCAAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACT
TACTGCCCAGATGTACCTTTACCAAAGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTTGCAACAAATGGGAAAT
TGTTTCCATGGGCACAGATCAGGCTTCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACAT
TCAGGGGTTCTGTGACAATTTCAGTTCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCATAATATTTCAAGAGTGA
CCTTTATGTCAGCAGTTTCAAGCCAAGAAAAACAAGCTGAGATCCTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAG
CCCTTCTAGCAGGGCACAATTATACGTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTTTATGGCTTCTCCTACA
CAGATGAAAGTAATGAGAAAAAGTACTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAG
CATTTAAAGCCACTTTTATCATCAAGATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAGTCATCAGTCGTTCTAG
ATGATGGACTTGTTCAGGATGAGTTTTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGA
GTCAGGACGTAAATGGAACCCTGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAA
AACAGAAACGCATGAACACAAAAAAAACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAATAGTA
TGTTCTTATGTTTCTCCTTATGCATTTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAAGGAAC
TGTTGTCATGATCTGGAAATGTTTAAAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTTGTTAA
TATGATGTTTACCATGTGCACATAGTAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTATGTACT
GCAGAGTCTGATGAGCTGGCCTTTGTGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTTGACAG
CCAGGGTTACATATTGGGGACTTTTAAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGTTACAG
TGACATATATGCTGCAATATTTAACAACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGTGTGTT
ATTTAAAATATTACATATGCAGCTGGGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTTATATA
TTTCCTTACCATACAAGGTGCCTTGTTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTTTAAGT
ATAGTTGACAAGTGTATAAATGTTACACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACAATGTT
AGGAGAAATCTGAATTCTGTTAAGTTAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATCAGTTG
ATCACACTAAGAAAGCTTAAAGATTGAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCATTGCG
CTGTGATTTCATCTGTGATGTGAAAAATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGCTTGAA
ATGACTTAAACTGTAATCCAAATGGGACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTAGCTTG
AAATTTATGTTTAGAAAAACTATTGATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAAATAGT
CATATATTAATTAACTTATAGGAAATAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATGCAATT
AAAGAAGTTCATAGATTTCACATGAATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTGTTTGT

>45868_45868_1_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000231368_PPIP5K2_chr5_102537222_ENST00000358359_length(amino acids)=463AA_BP=444
MCFSLLLPSLFLQLPRKPGTAERRRPSRHLPGSPWRPRWACSVSWAASALGVGSSGAPAVRSRGGGKMEPFTNDRLQLPRNMIENSMFEE
EPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVV
CAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQV
TWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQ
FEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLLQVDLL

--------------------------------------------------------------
>45868_45868_2_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000231368_PPIP5K2_chr5_102537223_ENST00000358359_length(transcript)=3508nt_BP=1823nt
TCCGCGGCCAACCTCCCCAGGGAAACCAGCGATTCGCGGTTCAGATAGCGACCTTCGCCCGCAGGTTCCTGCTCTGCCTTCAGACTTCGG
CTTCAGTGGCACCTGCTCAGCGAGGCCTCGTCTAACCAAGCCATCCGAATTAACTACCCACTCACTCGCCATCACATCACCCCGATTTAA
TTCGCAGCGGGGCACTGACTTTACACTCGTGTGTCTTCTGTGTTTATTTATGGTCTGTTTCTGGAATGTCCGCTCCTGGGACTGGGACCA
TGATTTTCTGGCGCAGTGCGGGTGTCTCGGCGTCCGGGATCGGGCGGGTCGCAGTAGGGCTCCACATTTGTTGAGTGACTGAACACCGTT
CCCGGCCGGGGAGAGCGCCGCAGCCGGGTCCACTTCAGGTAGGGGCTGGGCTTTCCCGGCCCCGCCTAGGCCCCGCCCCCAGCGCGAACC
CGCTCCCACCTCGCCTGTCCACGGAGCAGCAGGGGGTTTGACTGTGCTTTTCCCTCTTGCTTCCCTCGCTCTTTCTGCAGCTGCCACGAA
AACCCGGAACGGCGGAGCGGCGCCGCCCCTCGCGGCACCTCCCTGGCAGCCCTTGGAGGCCGCGCTGGGCATGCTCAGTCAGCTGGGCCG
CCTCAGCTCTCGGAGTAGGAAGCTCGGGCGCTCCGGCTGTAAGGAGCCGCGGCGGGGGGAAAATGGAGCCCTTCACCAATGATCGGCTTC
AGCTCCCCAGGAATATGATTGAAAACAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCTTGTTTACATCCTCTAG
AGCCTGATGAGGTGGAATATGAGCCCCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATT
ATGAGTCATCAGCAAAGCTGCTGGGCATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGTTACAGGCAGAGCCCAG
ATGGGGCTTGTTCAGTACCCTCTGCAAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACT
TACTGCCCAGATGTACCTTTACCAAAGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTTGCAACAAATGGGAAAT
TGTTTCCATGGGCACAGATCAGGCTTCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACAT
TCAGGGGTTCTGTGACAATTTCAGTTCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCATAATATTTCAAGAGTGA
CCTTTATGTCAGCAGTTTCAAGCCAAGAAAAACAAGCTGAGATCCTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAG
CCCTTCTAGCAGGGCACAATTATACGTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTTTATGGCTTCTCCTACA
CAGATGAAAGTAATGAGAAAAAGTACTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAG
CATTTAAAGCCACTTTTATCATCAAGATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAGTCATCAGTCGTTCTAG
ATGATGGACTTGTTCAGGATGAGTTTTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGA
GTCAGGACGTAAATGGAACCCTGCTACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAA
AACAGAAACGCATGAACACAAAAAAAACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAATAGTA
TGTTCTTATGTTTCTCCTTATGCATTTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAAGGAAC
TGTTGTCATGATCTGGAAATGTTTAAAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTTGTTAA
TATGATGTTTACCATGTGCACATAGTAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTATGTACT
GCAGAGTCTGATGAGCTGGCCTTTGTGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTTGACAG
CCAGGGTTACATATTGGGGACTTTTAAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGTTACAG
TGACATATATGCTGCAATATTTAACAACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGTGTGTT
ATTTAAAATATTACATATGCAGCTGGGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTTATATA
TTTCCTTACCATACAAGGTGCCTTGTTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTTTAAGT
ATAGTTGACAAGTGTATAAATGTTACACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACAATGTT
AGGAGAAATCTGAATTCTGTTAAGTTAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATCAGTTG
ATCACACTAAGAAAGCTTAAAGATTGAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCATTGCG
CTGTGATTTCATCTGTGATGTGAAAAATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGCTTGAA
ATGACTTAAACTGTAATCCAAATGGGACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTAGCTTG
AAATTTATGTTTAGAAAAACTATTGATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAAATAGT
CATATATTAATTAACTTATAGGAAATAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATGCAATT
AAAGAAGTTCATAGATTTCACATGAATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTGTTTGT

>45868_45868_2_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000231368_PPIP5K2_chr5_102537223_ENST00000358359_length(amino acids)=463AA_BP=444
MCFSLLLPSLFLQLPRKPGTAERRRPSRHLPGSPWRPRWACSVSWAASALGVGSSGAPAVRSRGGGKMEPFTNDRLQLPRNMIENSMFEE
EPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMEEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVV
CAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQV
TWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQ
FEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLLQVDLL

--------------------------------------------------------------
>45868_45868_3_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000395770_PPIP5K2_chr5_102537222_ENST00000358359_length(transcript)=3123nt_BP=1438nt
GCTCCTAACTCCACTAAGTACAGAAGTGGAGCCGTACAGCCATGAATGTCAGGCATGTTGTGGGGACTAGTTGTATTAGTTTTCTATTGC
CACCATAACAAATTACCACAAACTTAAGCAATATAGTACAAATTTATCTTAAAGTTATTGGCAGGTCAGAAGCCTGATACGGATCTCATT
GGGCTAAAACGAAGGAGTTGGCAGGGCTGTGTGTTCCTTTCTGTAGGCTCTGGGCAGGATCCATTTCCTGCACTTTTTTGGCTTTTGGAG
GTCGTCCACATTCCTTGGCTCCTGGCCCTGCTCCTTCATCTTCAAAGCTACCAAAGATCGGCTTCAGCTCCCCAGGAATATGATTGAAAA
CAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCTTGTTTACATCCTCTAGAGCCTGATGAGGTGGAATATGAGCC
CCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATTATGAGTCATCAGCAAAGCTGCTGGG
CATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGTTACAGGCAGAGCCCAGATGGGGCTTGTTCAGTACCCTCTGC
AAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACTTACTGCCCAGATGTACCTTTACCAA
AGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTTGCAACAAATGGGAAATTGTTTCCATGGGCACAGATCAGGCT
TCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACATTCAGGGGTTCTGTGACAATTTCAGT
TCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCATAATATTTCAAGAGTGACCTTTATGTCAGCAGTTTCAAGCCA
AGAAAAACAAGCTGAGATCCTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAGCCCTTCTAGCAGGGCACAATTATAC
GTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTTTATGGCTTCTCCTACACAGATGAAAGTAATGAGAAAAAGTA
CTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAGCATTTAAAGCCACTTTTATCATCAA
GATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAGTCATCAGTCGTTCTAGATGATGGACTTGTTCAGGATGAGTT
TTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGAGTCAGGACGTAAATGGAACCCTGCT
ACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAAAACAGAAACGCATGAACACAAAAAA
AACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAATAGTATGTTCTTATGTTTCTCCTTATGCAT
TTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAAGGAACTGTTGTCATGATCTGGAAATGTTTA
AAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTTGTTAATATGATGTTTACCATGTGCACATAG
TAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTATGTACTGCAGAGTCTGATGAGCTGGCCTTTG
TGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTTGACAGCCAGGGTTACATATTGGGGACTTTT
AAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGTTACAGTGACATATATGCTGCAATATTTAAC
AACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGTGTGTTATTTAAAATATTACATATGCAGCTG
GGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTTATATATTTCCTTACCATACAAGGTGCCTTG
TTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTTTAAGTATAGTTGACAAGTGTATAAATGTTA
CACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACAATGTTAGGAGAAATCTGAATTCTGTTAAGT
TAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATCAGTTGATCACACTAAGAAAGCTTAAAGATT
GAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCATTGCGCTGTGATTTCATCTGTGATGTGAAA
AATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGCTTGAAATGACTTAAACTGTAATCCAAATGG
GACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTAGCTTGAAATTTATGTTTAGAAAAACTATTG
ATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAAATAGTCATATATTAATTAACTTATAGGAAA
TAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATGCAATTAAAGAAGTTCATAGATTTCACATGA
ATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTGTTTGTGAAAATGTAGTTAATGTACTCACTG

>45868_45868_3_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000395770_PPIP5K2_chr5_102537222_ENST00000358359_length(amino acids)=422AA_BP=403
MGRIHFLHFFGFWRSSTFLGSWPCSFIFKATKDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEME
EDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPF
ATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIA
IVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKK

--------------------------------------------------------------
>45868_45868_4_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000395770_PPIP5K2_chr5_102537223_ENST00000358359_length(transcript)=3123nt_BP=1438nt
GCTCCTAACTCCACTAAGTACAGAAGTGGAGCCGTACAGCCATGAATGTCAGGCATGTTGTGGGGACTAGTTGTATTAGTTTTCTATTGC
CACCATAACAAATTACCACAAACTTAAGCAATATAGTACAAATTTATCTTAAAGTTATTGGCAGGTCAGAAGCCTGATACGGATCTCATT
GGGCTAAAACGAAGGAGTTGGCAGGGCTGTGTGTTCCTTTCTGTAGGCTCTGGGCAGGATCCATTTCCTGCACTTTTTTGGCTTTTGGAG
GTCGTCCACATTCCTTGGCTCCTGGCCCTGCTCCTTCATCTTCAAAGCTACCAAAGATCGGCTTCAGCTCCCCAGGAATATGATTGAAAA
CAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCTTGTTTACATCCTCTAGAGCCTGATGAGGTGGAATATGAGCC
CCGGGGTTCCCGACTGCTGGTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATTATGAGTCATCAGCAAAGCTGCTGGG
CATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGTTACAGGCAGAGCCCAGATGGGGCTTGTTCAGTACCCTCTGC
AAGGACCATGGTGGTCTGTGCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACTTACTGCCCAGATGTACCTTTACCAA
AGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTTGCAACAAATGGGAAATTGTTTCCATGGGCACAGATCAGGCT
TCCCACTGCCGTTGTGCCACTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACATTCAGGGGTTCTGTGACAATTTCAGT
TCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCATAATATTTCAAGAGTGACCTTTATGTCAGCAGTTTCAAGCCA
AGAAAAACAAGCTGAGATCCTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAGCCCTTCTAGCAGGGCACAATTATAC
GTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTTTATGGCTTCTCCTACACAGATGAAAGTAATGAGAAAAAGTA
CTTTGCAGCAACTCAGTTTGAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAGCATTTAAAGCCACTTTTATCATCAA
GATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAGTCATCAGTCGTTCTAGATGATGGACTTGTTCAGGATGAGTT
TTCTGAGAGTGTGAAGATGAGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGAGTCAGGACGTAAATGGAACCCTGCT
ACAAGTGGACCTTCTAGTGCAGTTGTTCCTAATACCTCATCTCGGAAAAAGAATATAACTAGCAAAACAGAAACGCATGAACACAAAAAA
AACACTGGGAAAAAGAAATGAAATCTTAGCAGAAGCTGGAACTTTTTATACTTATAAAAATAGTATGTTCTTATGTTTCTCCTTATGCAT
TTATGTGTTCACTTAAAAATGTTTTTAAATCTAAGGTTTTCTTTGTTTATGTTCAGGTAAGGAACTGTTGTCATGATCTGGAAATGTTTA
AAACAATGTTTGTTAGCATTCTGTGAGCAGCAAAACTTATAGTGATAAAAATCGATTGTTGTTAATATGATGTTTACCATGTGCACATAG
TAATGAAAAGGAACATAAAAGCCCAGCAGGCTCGTACCAAAGTCACAGCAGTAATGCTATGTACTGCAGAGTCTGATGAGCTGGCCTTTG
TGCACACTTTTATTTTCATGGGATTGCATCTTAGCTGTTAAAACTTCTAGATTGAAATTTGACAGCCAGGGTTACATATTGGGGACTTTT
AAAGTGTCTTTCCAAAGAGATTTCATTAACCGTTTAGATTAGAATATCTTTCCCAATTGTTACAGTGACATATATGCTGCAATATTTAAC
AACTGGAGTATTAGCCACATGGGTTATTTTTTCAATCTGTGTTTTGAATTTTTTTATTGTGTGTTATTTAAAATATTACATATGCAGCTG
GGAGAACTACACCTTTGTGCACATAGATTTATATATTAATTTGTAGAAAATATTTTCTTTATATATTTCCTTACCATACAAGGTGCCTTG
TTCATCAGGAAAACTTTTGTTTTGTATTTTGACAAGAAAGGCACCTTCAGAGTTTCTTTTTAAGTATAGTTGACAAGTGTATAAATGTTA
CACTTACTTTCAGAGTTCTTTTTAGATCTAAAGAAGTCAGTTCAAAAATGGAAATCAACAATGTTAGGAGAAATCTGAATTCTGTTAAGT
TAGTAAGTATTATGTATAGCATCTGTTTTTAACCATTTCCATTCTTATCCCTAGTGTATCAGTTGATCACACTAAGAAAGCTTAAAGATT
GAGCATTTGAAATAAATGCTCTTTATAAATGATTAGATTTTTGAAGGGATATTGAAATCATTGCGCTGTGATTTCATCTGTGATGTGAAA
AATCAATTTATTATCCTTGGTGCTTTCCCCCCCACCAATGCACAAATAATTGTGAACAGCTTGAAATGACTTAAACTGTAATCCAAATGG
GACAATCTGATAAGAATTTCATGCATTGGTAGTTAAATAACTTAAATTGCTAAAGCTTTAGCTTGAAATTTATGTTTAGAAAAACTATTG
ATTTCCCATGGTATGAATATAACTATTGTAATTCTTCAAATGAGACTCTTCTCACCTTAAATAGTCATATATTAATTAACTTATAGGAAA
TAAGCATACTATATGTTAGCTGTTTTAAAAGGTACCAGATGTAAGAGTCATAAATATATGCAATTAAAGAAGTTCATAGATTTCACATGA
ATGTAAATGTGTTATATGGAGACATGTCTTGTAAACAGTTGAATGTATGTAAGTTTTCTGTTTGTGAAAATGTAGTTAATGTACTCACTG

>45868_45868_4_LNPEP-PPIP5K2_LNPEP_chr5_96322374_ENST00000395770_PPIP5K2_chr5_102537223_ENST00000358359_length(amino acids)=422AA_BP=403
MGRIHFLHFFGFWRSSTFLGSWPCSFIFKATKDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEME
EDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGACSVPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEGCHKKNQSIGLIQPF
ATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIA
IVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LNPEP-PPIP5K2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LNPEP-PPIP5K2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LNPEP-PPIP5K2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource