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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ANKRD27-ZFP14 (FusionGDB2 ID:4656) |
Fusion Gene Summary for ANKRD27-ZFP14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKRD27-ZFP14 | Fusion gene ID: 4656 | Hgene | Tgene | Gene symbol | ANKRD27 | ZFP14 | Gene ID | 84079 | 57677 |
| Gene name | ankyrin repeat domain 27 | ZFP14 zinc finger protein | |
| Synonyms | PP12899|VARP | ZNF531 | |
| Cytomap | 19q13.11 | 19q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat domain-containing protein 27VPS9 domain-containing proteinVPS9-ankyrin-repeat proteinVps9 domain and ankyrin-repeat-containing proteinankyrin repeat domain 27 (VPS9 domain) | zinc finger protein 14 homologzinc finger protein 531 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q96NW4 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000306065, ENST00000587352, | ENST00000589280, ENST00000270001, | |
| Fusion gene scores | * DoF score | 14 X 14 X 8=1568 | 1 X 1 X 1=1 |
| # samples | 16 | 1 | |
| ** MAII score | log2(16/1568*10)=-3.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ANKRD27 [Title/Abstract] AND ZFP14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ANKRD27(33134029)-ZFP14(36832492), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANKRD27 | GO:0035544 | negative regulation of SNARE complex assembly | 24856514 |
| Hgene | ANKRD27 | GO:0045022 | early endosome to late endosome transport | 16525121 |
| Fusion gene breakpoints across ANKRD27 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ZFP14 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-66-2742-01A | ANKRD27 | chr19 | 33134029 | - | ZFP14 | chr19 | 36832492 | - |
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Fusion Gene ORF analysis for ANKRD27-ZFP14 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000306065 | ENST00000589280 | ANKRD27 | chr19 | 33134029 | - | ZFP14 | chr19 | 36832492 | - |
| 5CDS-intron | ENST00000587352 | ENST00000589280 | ANKRD27 | chr19 | 33134029 | - | ZFP14 | chr19 | 36832492 | - |
| In-frame | ENST00000306065 | ENST00000270001 | ANKRD27 | chr19 | 33134029 | - | ZFP14 | chr19 | 36832492 | - |
| In-frame | ENST00000587352 | ENST00000270001 | ANKRD27 | chr19 | 33134029 | - | ZFP14 | chr19 | 36832492 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000306065 | ANKRD27 | chr19 | 33134029 | - | ENST00000270001 | ZFP14 | chr19 | 36832492 | - | 6272 | 941 | 943 | 2307 | 454 |
| ENST00000587352 | ANKRD27 | chr19 | 33134029 | - | ENST00000270001 | ZFP14 | chr19 | 36832492 | - | 6242 | 911 | 913 | 2277 | 454 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000306065 | ENST00000270001 | ANKRD27 | chr19 | 33134029 | - | ZFP14 | chr19 | 36832492 | - | 0.000282194 | 0.9997178 |
| ENST00000587352 | ENST00000270001 | ANKRD27 | chr19 | 33134029 | - | ZFP14 | chr19 | 36832492 | - | 0.000282044 | 0.9997179 |
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Fusion Genomic Features for ANKRD27-ZFP14 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ANKRD27-ZFP14 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:33134029/chr19:36832492) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKRD27 | . |
| FUNCTION: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:Q3UMR0, ECO:0000269|PubMed:23104059, ECO:0000269|PubMed:24856514, ECO:0000305|PubMed:16525121, ECO:0000305|PubMed:18477474, ECO:0000305|PubMed:22705394}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 172_194 | 78 | 534.0 | Zinc finger | C2H2-type 1 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 200_222 | 78 | 534.0 | Zinc finger | C2H2-type 2 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 228_250 | 78 | 534.0 | Zinc finger | C2H2-type 3 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 256_278 | 78 | 534.0 | Zinc finger | C2H2-type 4 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 284_306 | 78 | 534.0 | Zinc finger | C2H2-type 5 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 312_334 | 78 | 534.0 | Zinc finger | C2H2-type 6 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 340_362 | 78 | 534.0 | Zinc finger | C2H2-type 7 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 368_390 | 78 | 534.0 | Zinc finger | C2H2-type 8 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 396_418 | 78 | 534.0 | Zinc finger | C2H2-type 9 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 424_446 | 78 | 534.0 | Zinc finger | C2H2-type 10 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 452_474 | 78 | 534.0 | Zinc finger | C2H2-type 11 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 480_502 | 78 | 534.0 | Zinc finger | C2H2-type 12 | |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 508_530 | 78 | 534.0 | Zinc finger | C2H2-type 13 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 233_371 | 260 | 1051.0 | Domain | VPS9 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 1_372 | 260 | 1051.0 | Region | Sufficient for GEF activity towards RAB21 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 396_426 | 260 | 1051.0 | Repeat | Note=ANK 1 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 462_491 | 260 | 1051.0 | Repeat | Note=ANK 2 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 495_524 | 260 | 1051.0 | Repeat | Note=ANK 3 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 528_560 | 260 | 1051.0 | Repeat | Note=ANK 4 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 564_593 | 260 | 1051.0 | Repeat | Note=ANK 5 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 597_627 | 260 | 1051.0 | Repeat | Note=ANK 6 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 668_698 | 260 | 1051.0 | Repeat | Note=ANK 7 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 743_772 | 260 | 1051.0 | Repeat | Note=ANK 8 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 776_805 | 260 | 1051.0 | Repeat | Note=ANK 9 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 809_838 | 260 | 1051.0 | Repeat | Note=ANK 10 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 842_871 | 260 | 1051.0 | Repeat | Note=ANK 11 |
| Tgene | ZFP14 | chr19:33134029 | chr19:36832492 | ENST00000270001 | 3 | 5 | 6_78 | 78 | 534.0 | Domain | KRAB |
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Fusion Gene Sequence for ANKRD27-ZFP14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >4656_4656_1_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000306065_ZFP14_chr19_36832492_ENST00000270001_length(transcript)=6272nt_BP=941nt GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGATTTGGAGTCCAGATACAGGACCAATACTTTATCTCCAGAAAAGGACAT TTATGAAATATATTCATTTCAGTGGGATATAATGGAAAGAATTAAAAGCTATAGCCTTCAGGGTTCCATTTTTAGGAATGATTGGGAATG CAAAAGCAAGATTGAGGGGGAAAAGGAACAACAAGAGGGATATTTTGGGCAAGTGAAAATTACCTCTGAAAAAATGACCACTTACAAAAG GCACAATTTTCTTACTGAGTATCAGATCGTTCATAATGGAGAAAAGGTGTATGAGTGTAAGGAGTGTAGGAAGACCTTTATTCGTCGCTC AACACTTAGTCAACACCTGAGAATTCATACTGGTGAGAAACCTTATAAGTGTAAGGAATGTGGGCAGGCCTTTAGACAGCGTGCACATCT TATTCGACATCACAAACTTCACACCGGTGAGAAACCCTATGAATGTAAGGAGTGTGGGAAGGCCTTTACAGTGCTCCAAGAACTTACTCA ACATCAGAGACTTCATACGGGTGAAAAACCCTATGAATGTAAGGAATGTGGAAAGGCCTTTAGAGTACATCAGCAACTGGCTCGACATCA GAGAATTCACACTGGTGAGAAACCCTATGAATGTAAGGACTGTGGAAAGACCTTTAGACAGTGTACACACCTTACACGCCATCAGAGACT TCATACTGCTGAAAAGCTCTATGAATGTAAGGAATGTGGGAAAGCCTTCGTATGTGGTCCAGACCTTAGAGTACATCAGAAAATTCATTT TGGTGAGAAACCCTATGAATGTAAGGAGTGTGGAAAGGCTTTTAGAATATGCCAACAACTTACTGTTCATCAGAGTATTCATACTGGTGA GAAACCCTACGAATGTAAGGAATGTGGGAAGACTTTTAGATTAAGACAACAACTAGTTCGCCATCAGAGAATACATACTCGTGAGAAACC CTATGAATGTATGGAATGTTGGAAGACCTTTAGTAGTTACTCACAGCTTATTTCACACCAGAGCATTCATATTGGTGAGAGACCCTATGA ATGTGAAGAGTGTGGAAAGGCCTTTAGACTGCTCTCACAACTTACTCAGCATCAAAGTATTCACACTGGTGAGAAACCTTATGAATGTAA GGAATGTAGAAAACCTTTTAGACTGCTCTCACAACTTACCCAACATCAGAGTATTCACACTGGTGAGAAACCTTATGAATGTAAGGAATG TGGTAAGGCTTTTAGACTTTATTCATTTCTTACTCAACACCAGAGAATTCATACTGGTGAGAAGCCCTACAAGTGTAAGGAGTGTAAGAA GGCCTTTAGACAGCATTCACACCTTACTCAGCATCAGAAGATTCATAATGGAATTTAATAGAAGAAAGCCTTCAAATGTATATGATGTTA CAGAACATCAGAAAATTCATTTTTGAGAAAATGTGTTTCATGCTCAATTCCAAGCATAATAAATTTTATATTAGAGAAAGAATATGTTGA TTTAAAAGCCTTCCAACACCATTTAAACATGGTTTATCTTCAGCAAATTCCTATGAGAGAATAATGTAATGAATGTAGGAAAATCTTTAG CCTTATCTGTCATTATCTCCCTTTCTCCACTTGATTACCAGTTTGATTTATTGGACAAGATACTAAGCTTCTGTGCCTCATTTTGCTGAC TTGTAAAATGGTAATAATAGTACTTATATGTATTAGTTATTTATTGCTGCGTAATAAATTACCACAGACTTAGTAGCATAAAATAACATA TAATTATATCTTATAATTTGGATCAGGAGTATAGGCATGACTTAGTTGGGTCCTCTGCTTCAGGGTCTCTTGCAAGGCTACAGATTTCAG CCAGGGCTGAGGTCTCATCTGAAGGCTCAACTGGGGAAGGATCCACATCCAGACTAACATAGTTGTTACCCAATGTATTTCCGTGAGGCC TGTTGCATTGAGATTCTCAGTTTCTAGCTGGCTGTTGGCTGAACGCTGACTGCAGCTCCTGGCCACAATAGCCTCATCAACATGGCTGCT TGCTTCATCAAGGCATGCAAGCCAAAAGGGAGGACAGTCTGCTAGCAAGATGGAAGTTACCATCTTGTGTAATCTAATCATGGAAGTAAC ATTCCCTCACCTTCTACTGGTAGAAGTAAGTTACTAGGATAGTCCACACTCAAGAGAACGGGATGATACAAGAGTGTGAATAAGTCCTGG AGACAGGACCACTGGGGGGCCTGTTTAGAGTCAGCCTGCCACACTGTGGAATAGGATTGTTGCAAGGAGTAAGTAGTTAATACTTGGAGG AATCACAGTCATATAGCATGTATTCTGTAAATATTATCTGTAATTGTTATTATTGTCATTAGTATTAGTGAATTCACGTAAAAGGAAGAT CTGTAGACATAATAAATGTAGAAATGCCTCCTGTCACCTCTCAGAAATTATTAAACATAATTTATTCTAGGTAAAATTTAGATTGTAGTG AATGTAGGAAGTTCTTCAGCACTTGAGCTGCATTAGAAATTTCATGCCAAAAATGAATTTCATGAATGTGAGGTCACTAGTAATACAGCT GTTGAAGAATTAGAGGGAAATAGGAAATGATTTTCCCATAATTCCAGAAAGCAAAAGGCTTACAATCCCTGTTGTCTGACCACAGTTTAA AATTAATTAGAAACTATCAAAAATGTGGCTTAAAAGAAATTAACCACCTAGGAATTTAATATTGTTGTGTATATTTATGTGTGTGTATAA AACTCCTGTGGGAAAGAAACAAAACATCATTCTATAAGTCAGTATACTTTTGGATGCTCAAAATGCCATATCTTCAACCAGTAGGAGTTG TTTCAAGTTGAGTTTTTGATGTGATCCCACCAATAATTTGATAGTTTACTTGATTGTGGCTGCATAATTTGGTAACCTATGAAAGATGCT AGAGCACCAATGTATAATTTTTTTGAGACAGGGTGTCACTTTGTCCCCCAGGCTGGAGTGCAGTGGTACAAGCACAGTTCACTGTACCCT GTTCCTCCTGGGCTCAAGTGATTCTTCCACCTAAATTTTTTTTTTTTTTTTAGAGAAAGGGTCTCACTATGTTGCCCAGGCTGGTCTTGA ACTTCTGGGCTCAAGTGATCCTCCCTCCTTGGCCTCCAAAGGTGCTGGGGTTACAGGTATGAGCCACCACACCCAGCCCAACTCATTATT CTTGAAATCAATAAATCAGAGGAAAAATTGTCATTTAGTTTCCTTTTCCCATGTGAACCAAATTTCAGGGTCACCAGAAGTTCATCAAAT TCAAATGAATTTGGCCTGGCACAGGGGTCACACCTGTAATCCCAGCACTTTGGGAGGACAAGGTGGGTGGATCACTTGAGGCCAGGAGTT TGAGACCAACCTGGTTAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAATTTAGCCAGGCATGGTGGCACACACCTGTAGTCCCAG GCTGAGGTGGGAGGATCACTTGAACCCAAGAGGCAGAGTTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTG AGACCCTGTCTCAAAAAAAAAATTTGTTTTTTGAATGGGTTTTTCTTTTTTGAAGAAGTCTAATAAATCTAGAAGGAATTAGAGGATTAG AAAAATCACCATTTTCTAGACCTTAATGGAATAATGGGTCCAGAAAACATGATCTTCAATGGGTACTACAACTAATAGGTGAAATATTTT ATAGCGAGATTTTTATGGTGGATCTATCAAACTGGCCACCTCTGAACCCTTTGATCTGTTTTAACCTTAATAAAAATGGGTCTATCAGAC AACACACTTCCTGACGTAATGCAATAGGAAGTCCACACCACCATCTACAAAGCCTTATTGCTGGAATAATGAACTGAAAGCAGACAGGGA CTAGATGAACAGTATATGGTCATCCCTTGGTATCCATGGGGAATTGGTTCCAGGATCCTCCACTGATGGTAAAATCTGAGGATGCTCAAG TCCCTTGTATAAAATGGCATAGTATGTATTTGCATATTACCTACTCACATCTTCCTGTATACTTTAAATTATCTTTAGATCACTTATACC TATCACAATGTAAATACTATGTAAATAGTTGTTATACTGTATTTTTCAATTTGCATTATTTTTATTGTATTTTATTTTTATTGTTTTTTT TTGAGTATTTTCTATTTGAGATTGGTTGAATCTGCACATATGGAGGGCTGGCTATAAAGGGCACCACAAGGAAGAAGCCAAACAGATCCA GAATGTGTGAAATTCTACAGAGCAAATTACCTGATTTCTTCAACTAACAGGTAGCATGAAAATACAAGGGGAAGGGCAACCATTAACAGA TTAAAAGAGACTTAAAGAGACATATCAACTAAATTCAGTATGTTGGCATTACTTGGACCTGGTTTGAACAAAACATAAAAAGCCATTTTG GAGACAGTGAGGGAAGTGTGGACATGGACTAAATATTAAATGATATTTACATATATTAATTTGGTTAGGGATTATGTCAGTGTGATTATA AAAAATAAAAGATCGTATGATATGAGATACATACTATGAAATGAAGATAGACACATTTGGATTAAAATATTCTAGCAAAAGAAATAATTG GCAAAGAGAGCTGGAAACTAAATTGGCAACATGTTGATAATTTAAGTGGAGTGTTTTGTTCATGGAGACTTATTGTTCTAATATTTCTAC TTTTGTATGTGTTTGAAATTTCAATAATAAAATGTTTAAAATCAAAACCAAAATTATAGACTATGTAGAAATGAATGACAGTGAGATGCC TGCACATCTAACCTTGTCAGATATAATCAAAGTTCTGTTCAGTGACAAATTAATGCCCTGTAATGTGGTAAGGAAATCTTATTTGTGGAT ACAGTCTTCATCTTCTTCACTTACCCACAGCAGCAACACCAGGCCTGTCACACAGATGAATGTGTTGAGGGAATGAATAAGTATTTCCGT CAAGAAAAAGGAAACAACAAAATAAAACCAACCCAAGTAAAGAACAGCCAAGTGGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCAC TTTGGGAGGCCATGGCAGGTGGATCACCTGAGGTCGGGATTTTGAGACCAGCCTGACCAACACTGAGAAACCCCATCTCTATTAAAGATA CAAAATTAGCCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTAAGGCAGGAGAATCACTTGAATCCAGGAGGCGGAG >4656_4656_1_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000306065_ZFP14_chr19_36832492_ENST00000270001_length(amino acids)=454AA_BP=79 MESRYRTNTLSPEKDIYEIYSFQWDIMERIKSYSLQGSIFRNDWECKSKIEGEKEQQEGYFGQVKITSEKMTTYKRHNFLTEYQIVHNGE KVYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECK ECGKAFRVHQQLARHQRIHTGEKPYECKDCGKTFRQCTHLTRHQRLHTAEKLYECKECGKAFVCGPDLRVHQKIHFGEKPYECKECGKAF RICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQL TQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKI -------------------------------------------------------------- >4656_4656_2_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000587352_ZFP14_chr19_36832492_ENST00000270001_length(transcript)=6242nt_BP=911nt GCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCGCCCAGGATGGGCTGGGAATGAAGCGATGTA GCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGACCTCCTGAAAAATCCTTTCTATCTGGCTCTG CAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTACCCTGCAAAGGAAGCCTGTCGAGCAGCATC CAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACCTTAAATGGAAAGGATGTCTTTATTCAAGGG AACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAAGAAACTTTCTACAATGAAAAAGAAGAGAGT TTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTGGCACCCTCAGATCCCTTTTCCCTGAAAACC ATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCCTCTTTCCATCGAACATTCCGAGAATGCGAG AGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAGCAGCTTCTGAGGGACTCTCACCTGAAAATG CTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCATCATGAAATTTACAACCTGATCTTTAAATAC GTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAAGATCTTCAGCAGAAAGATATTGGTGTGAAA CCGGAGTTCAGATTTGGAGTCCAGATACAGGACCAATACTTTATCTCCAGAAAAGGACATTTATGAAATATATTCATTTCAGTGGGATAT AATGGAAAGAATTAAAAGCTATAGCCTTCAGGGTTCCATTTTTAGGAATGATTGGGAATGCAAAAGCAAGATTGAGGGGGAAAAGGAACA ACAAGAGGGATATTTTGGGCAAGTGAAAATTACCTCTGAAAAAATGACCACTTACAAAAGGCACAATTTTCTTACTGAGTATCAGATCGT TCATAATGGAGAAAAGGTGTATGAGTGTAAGGAGTGTAGGAAGACCTTTATTCGTCGCTCAACACTTAGTCAACACCTGAGAATTCATAC TGGTGAGAAACCTTATAAGTGTAAGGAATGTGGGCAGGCCTTTAGACAGCGTGCACATCTTATTCGACATCACAAACTTCACACCGGTGA GAAACCCTATGAATGTAAGGAGTGTGGGAAGGCCTTTACAGTGCTCCAAGAACTTACTCAACATCAGAGACTTCATACGGGTGAAAAACC CTATGAATGTAAGGAATGTGGAAAGGCCTTTAGAGTACATCAGCAACTGGCTCGACATCAGAGAATTCACACTGGTGAGAAACCCTATGA ATGTAAGGACTGTGGAAAGACCTTTAGACAGTGTACACACCTTACACGCCATCAGAGACTTCATACTGCTGAAAAGCTCTATGAATGTAA GGAATGTGGGAAAGCCTTCGTATGTGGTCCAGACCTTAGAGTACATCAGAAAATTCATTTTGGTGAGAAACCCTATGAATGTAAGGAGTG TGGAAAGGCTTTTAGAATATGCCAACAACTTACTGTTCATCAGAGTATTCATACTGGTGAGAAACCCTACGAATGTAAGGAATGTGGGAA GACTTTTAGATTAAGACAACAACTAGTTCGCCATCAGAGAATACATACTCGTGAGAAACCCTATGAATGTATGGAATGTTGGAAGACCTT TAGTAGTTACTCACAGCTTATTTCACACCAGAGCATTCATATTGGTGAGAGACCCTATGAATGTGAAGAGTGTGGAAAGGCCTTTAGACT GCTCTCACAACTTACTCAGCATCAAAGTATTCACACTGGTGAGAAACCTTATGAATGTAAGGAATGTAGAAAACCTTTTAGACTGCTCTC ACAACTTACCCAACATCAGAGTATTCACACTGGTGAGAAACCTTATGAATGTAAGGAATGTGGTAAGGCTTTTAGACTTTATTCATTTCT TACTCAACACCAGAGAATTCATACTGGTGAGAAGCCCTACAAGTGTAAGGAGTGTAAGAAGGCCTTTAGACAGCATTCACACCTTACTCA GCATCAGAAGATTCATAATGGAATTTAATAGAAGAAAGCCTTCAAATGTATATGATGTTACAGAACATCAGAAAATTCATTTTTGAGAAA ATGTGTTTCATGCTCAATTCCAAGCATAATAAATTTTATATTAGAGAAAGAATATGTTGATTTAAAAGCCTTCCAACACCATTTAAACAT GGTTTATCTTCAGCAAATTCCTATGAGAGAATAATGTAATGAATGTAGGAAAATCTTTAGCCTTATCTGTCATTATCTCCCTTTCTCCAC TTGATTACCAGTTTGATTTATTGGACAAGATACTAAGCTTCTGTGCCTCATTTTGCTGACTTGTAAAATGGTAATAATAGTACTTATATG TATTAGTTATTTATTGCTGCGTAATAAATTACCACAGACTTAGTAGCATAAAATAACATATAATTATATCTTATAATTTGGATCAGGAGT ATAGGCATGACTTAGTTGGGTCCTCTGCTTCAGGGTCTCTTGCAAGGCTACAGATTTCAGCCAGGGCTGAGGTCTCATCTGAAGGCTCAA CTGGGGAAGGATCCACATCCAGACTAACATAGTTGTTACCCAATGTATTTCCGTGAGGCCTGTTGCATTGAGATTCTCAGTTTCTAGCTG GCTGTTGGCTGAACGCTGACTGCAGCTCCTGGCCACAATAGCCTCATCAACATGGCTGCTTGCTTCATCAAGGCATGCAAGCCAAAAGGG AGGACAGTCTGCTAGCAAGATGGAAGTTACCATCTTGTGTAATCTAATCATGGAAGTAACATTCCCTCACCTTCTACTGGTAGAAGTAAG TTACTAGGATAGTCCACACTCAAGAGAACGGGATGATACAAGAGTGTGAATAAGTCCTGGAGACAGGACCACTGGGGGGCCTGTTTAGAG TCAGCCTGCCACACTGTGGAATAGGATTGTTGCAAGGAGTAAGTAGTTAATACTTGGAGGAATCACAGTCATATAGCATGTATTCTGTAA ATATTATCTGTAATTGTTATTATTGTCATTAGTATTAGTGAATTCACGTAAAAGGAAGATCTGTAGACATAATAAATGTAGAAATGCCTC CTGTCACCTCTCAGAAATTATTAAACATAATTTATTCTAGGTAAAATTTAGATTGTAGTGAATGTAGGAAGTTCTTCAGCACTTGAGCTG CATTAGAAATTTCATGCCAAAAATGAATTTCATGAATGTGAGGTCACTAGTAATACAGCTGTTGAAGAATTAGAGGGAAATAGGAAATGA TTTTCCCATAATTCCAGAAAGCAAAAGGCTTACAATCCCTGTTGTCTGACCACAGTTTAAAATTAATTAGAAACTATCAAAAATGTGGCT TAAAAGAAATTAACCACCTAGGAATTTAATATTGTTGTGTATATTTATGTGTGTGTATAAAACTCCTGTGGGAAAGAAACAAAACATCAT TCTATAAGTCAGTATACTTTTGGATGCTCAAAATGCCATATCTTCAACCAGTAGGAGTTGTTTCAAGTTGAGTTTTTGATGTGATCCCAC CAATAATTTGATAGTTTACTTGATTGTGGCTGCATAATTTGGTAACCTATGAAAGATGCTAGAGCACCAATGTATAATTTTTTTGAGACA GGGTGTCACTTTGTCCCCCAGGCTGGAGTGCAGTGGTACAAGCACAGTTCACTGTACCCTGTTCCTCCTGGGCTCAAGTGATTCTTCCAC CTAAATTTTTTTTTTTTTTTTAGAGAAAGGGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTTCTGGGCTCAAGTGATCCTCCCTCCTT GGCCTCCAAAGGTGCTGGGGTTACAGGTATGAGCCACCACACCCAGCCCAACTCATTATTCTTGAAATCAATAAATCAGAGGAAAAATTG TCATTTAGTTTCCTTTTCCCATGTGAACCAAATTTCAGGGTCACCAGAAGTTCATCAAATTCAAATGAATTTGGCCTGGCACAGGGGTCA CACCTGTAATCCCAGCACTTTGGGAGGACAAGGTGGGTGGATCACTTGAGGCCAGGAGTTTGAGACCAACCTGGTTAACATGGTGAAACC CTGTCTGTACTAAAAATACAAAATTTAGCCAGGCATGGTGGCACACACCTGTAGTCCCAGGCTGAGGTGGGAGGATCACTTGAACCCAAG AGGCAGAGTTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAATTTGTTTT TTGAATGGGTTTTTCTTTTTTGAAGAAGTCTAATAAATCTAGAAGGAATTAGAGGATTAGAAAAATCACCATTTTCTAGACCTTAATGGA ATAATGGGTCCAGAAAACATGATCTTCAATGGGTACTACAACTAATAGGTGAAATATTTTATAGCGAGATTTTTATGGTGGATCTATCAA ACTGGCCACCTCTGAACCCTTTGATCTGTTTTAACCTTAATAAAAATGGGTCTATCAGACAACACACTTCCTGACGTAATGCAATAGGAA GTCCACACCACCATCTACAAAGCCTTATTGCTGGAATAATGAACTGAAAGCAGACAGGGACTAGATGAACAGTATATGGTCATCCCTTGG TATCCATGGGGAATTGGTTCCAGGATCCTCCACTGATGGTAAAATCTGAGGATGCTCAAGTCCCTTGTATAAAATGGCATAGTATGTATT TGCATATTACCTACTCACATCTTCCTGTATACTTTAAATTATCTTTAGATCACTTATACCTATCACAATGTAAATACTATGTAAATAGTT GTTATACTGTATTTTTCAATTTGCATTATTTTTATTGTATTTTATTTTTATTGTTTTTTTTTGAGTATTTTCTATTTGAGATTGGTTGAA TCTGCACATATGGAGGGCTGGCTATAAAGGGCACCACAAGGAAGAAGCCAAACAGATCCAGAATGTGTGAAATTCTACAGAGCAAATTAC CTGATTTCTTCAACTAACAGGTAGCATGAAAATACAAGGGGAAGGGCAACCATTAACAGATTAAAAGAGACTTAAAGAGACATATCAACT AAATTCAGTATGTTGGCATTACTTGGACCTGGTTTGAACAAAACATAAAAAGCCATTTTGGAGACAGTGAGGGAAGTGTGGACATGGACT AAATATTAAATGATATTTACATATATTAATTTGGTTAGGGATTATGTCAGTGTGATTATAAAAAATAAAAGATCGTATGATATGAGATAC ATACTATGAAATGAAGATAGACACATTTGGATTAAAATATTCTAGCAAAAGAAATAATTGGCAAAGAGAGCTGGAAACTAAATTGGCAAC ATGTTGATAATTTAAGTGGAGTGTTTTGTTCATGGAGACTTATTGTTCTAATATTTCTACTTTTGTATGTGTTTGAAATTTCAATAATAA AATGTTTAAAATCAAAACCAAAATTATAGACTATGTAGAAATGAATGACAGTGAGATGCCTGCACATCTAACCTTGTCAGATATAATCAA AGTTCTGTTCAGTGACAAATTAATGCCCTGTAATGTGGTAAGGAAATCTTATTTGTGGATACAGTCTTCATCTTCTTCACTTACCCACAG CAGCAACACCAGGCCTGTCACACAGATGAATGTGTTGAGGGAATGAATAAGTATTTCCGTCAAGAAAAAGGAAACAACAAAATAAAACCA ACCCAAGTAAAGAACAGCCAAGTGGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCATGGCAGGTGGATCACCTG AGGTCGGGATTTTGAGACCAGCCTGACCAACACTGAGAAACCCCATCTCTATTAAAGATACAAAATTAGCCAGGCATGGTGGTGCATGCC TGTAATCCCAGCTACTTGGGAGGCTAAGGCAGGAGAATCACTTGAATCCAGGAGGCGGAGTTTGTGGTGAGTTGAGATCGCGCCACTGCA >4656_4656_2_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000587352_ZFP14_chr19_36832492_ENST00000270001_length(amino acids)=454AA_BP=79 MESRYRTNTLSPEKDIYEIYSFQWDIMERIKSYSLQGSIFRNDWECKSKIEGEKEQQEGYFGQVKITSEKMTTYKRHNFLTEYQIVHNGE KVYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECK ECGKAFRVHQQLARHQRIHTGEKPYECKDCGKTFRQCTHLTRHQRLHTAEKLYECKECGKAFVCGPDLRVHQKIHFGEKPYECKECGKAF RICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQL TQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ANKRD27-ZFP14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 451_730 | 260.6666666666667 | 1051.0 | RAB32 |
| Hgene | ANKRD27 | chr19:33134029 | chr19:36832492 | ENST00000306065 | - | 9 | 29 | 451_600 | 260.6666666666667 | 1051.0 | RAB38 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ANKRD27-ZFP14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ANKRD27-ZFP14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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