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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD33B-MAML1 (FusionGDB2 ID:4703)

Fusion Gene Summary for ANKRD33B-MAML1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD33B-MAML1
Fusion gene ID: 4703
HgeneTgene
Gene symbol

ANKRD33B

MAML1

Gene ID

651746

9794

Gene nameankyrin repeat domain 33Bmastermind like transcriptional coactivator 1
Synonyms-Mam-1|Mam1
Cytomap

5p15.2

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 33BAnkyrin repeat domain-containing protein LOC651746mastermind-like protein 1mastermind homologmastermind-like 1
Modification date2020031320200322
UniProtAcc.

Q92585

Ensembl transtripts involved in fusion geneENST00000296657, ENST00000503050, 
ENST00000292599, 
Fusion gene scores* DoF score9 X 3 X 6=1625 X 5 X 4=100
# samples 126
** MAII scorelog2(12/162*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD33B [Title/Abstract] AND MAML1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD33B(10564945)-MAML1(179192327), # samples:1
ANKRD33B(10564945)-MAML1(179192326), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAML1

GO:0006468

protein phosphorylation

16510869

TgeneMAML1

GO:0007219

Notch signaling pathway

11101851

TgeneMAML1

GO:0045944

positive regulation of transcription by RNA polymerase II

11101851|16510869


check buttonFusion gene breakpoints across ANKRD33B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAML1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A914-01AANKRD33Bchr5

10564945

+MAML1chr5

179192327

+
ChimerDB4UCECTCGA-PG-A914ANKRD33Bchr5

10564945

+MAML1chr5

179192326

+


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Fusion Gene ORF analysis for ANKRD33B-MAML1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000296657ENST00000503050ANKRD33Bchr5

10564945

+MAML1chr5

179192327

+
5CDS-3UTRENST00000296657ENST00000503050ANKRD33Bchr5

10564945

+MAML1chr5

179192326

+
In-frameENST00000296657ENST00000292599ANKRD33Bchr5

10564945

+MAML1chr5

179192327

+
In-frameENST00000296657ENST00000292599ANKRD33Bchr5

10564945

+MAML1chr5

179192326

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296657ANKRD33Bchr510564945+ENST00000292599MAML1chr5179192327+5511366031011033
ENST00000296657ANKRD33Bchr510564945+ENST00000292599MAML1chr5179192326+5511366031011033

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296657ENST00000292599ANKRD33Bchr510564945+MAML1chr5179192327+0.0004108170.99958915
ENST00000296657ENST00000292599ANKRD33Bchr510564945+MAML1chr5179192326+0.0004108170.99958915

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Fusion Genomic Features for ANKRD33B-MAML1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD33Bchr510564945+MAML1chr5179192326+3.42E-060.99999654
ANKRD33Bchr510564945+MAML1chr5179192326+3.42E-060.99999654
ANKRD33Bchr510564945+MAML1chr5179192326+3.42E-060.99999654
ANKRD33Bchr510564945+MAML1chr5179192326+3.42E-060.99999654

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD33B-MAML1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:10564945/chr5:179192327)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAML1

Q92585

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+1419_25122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+1419_25122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+1484_113122495.0RepeatNote=ANK 1
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+1484_113122495.0RepeatNote=ANK 1
TgeneMAML1chr5:10564945chr5:179192326ENST0000029259905642_6451051017.0Compositional biasNote=Poly-Gln
TgeneMAML1chr5:10564945chr5:179192327ENST0000029259905642_6451051017.0Compositional biasNote=Poly-Gln

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+14459_488122495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+14459_488122495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+14264_267122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+14264_267122495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+14120_150122495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+14154_183122495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+14189_218122495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:179192326ENST00000296657+14223_255122495.0RepeatNote=ANK 5
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+14120_150122495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+14154_183122495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+14189_218122495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:179192327ENST00000296657+14223_255122495.0RepeatNote=ANK 5


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Fusion Gene Sequence for ANKRD33B-MAML1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4703_4703_1_ANKRD33B-MAML1_ANKRD33B_chr5_10564945_ENST00000296657_MAML1_chr5_179192326_ENST00000292599_length(transcript)=5511nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGCATCTTCATGATACAGTTAAGAGGAATCTTGACAGCGCCACTTCCCCTCAGAATGGCGATCAACAGAATGGCTACGGGGACCTC
TTTCCTGGGCATAAGAAGACTCGCCGGGAGGCCCCTCTGGGAGTTGCCATCTCTTCCAATGGACTGCCTCCAGCCTCCCCCCTCGGTCAG
TCTGACAAGCCTTCTGGAGCCGACGCCCTGCAGTCCAGTGGGAAGCACTCTCTGGGGCTAGACTCTCTCAACAAAAAGCGTCTGGCTGAC
TCCAGCCTTCACTTGAATGGAGGCAGTAACCCCAGTGAGTCATTTCCTCTGAGCCTGAATAAAGAACTGAAGCAGGAGCCTGTCGAAGAC
CTGCCTTGCATGATCACTGGGACTGTCGGCTCCATATCGCAAAGCAACCTCATGCCAGACCTCAACCTTAACGAGCAGGAGTGGAAGGAG
CTCATCGAGGAGCTGAACAGGTCGGTGCCCGATGAAGACATGAAGGACCTGTTTAATGAGGACTTCGAGGAGAAGAAGGACCCAGAGTCT
TCTGGCTCTGCCACACAAACCCCCTTGGCACAGGACATTAATATTAAGACGGAATTCTCTCCAGCAGCCTTTGAGCAAGAACAGTTAGGC
TCTCCACAAGTGAGGGCCGGGTCTGCAGGGCAGACCTTTCTGGGGCCTTCCTCTGCCCCTGTGAGTACAGATTCCCCCAGCCTAGGGGGC
TCCCAAACCTTATTCCACACCTCTGGTCAGCCCCGGGCGGACAATCCCAGTCCAAACCTGATGCCGGCATCAGCCCAGGCCCAGAACGCA
CAAAGAGCCCTTGCAGGTGTGGTATTGCCCAGTCAGGGCCCAGGAGGGGCCTCAGAGCTGTCCTCTGCCCACCAGCTCCAGCAGATCGCT
GCCAAGCAGAAGCGCGAGCAGATGCTCCAGAACCCACAGCAGGCCACCCCGGCACCAGCCCCGGGCCAGATGTCCACATGGCAGCAGACG
GGGCCCTCCCACAGTTCCTTAGATGTCCCTTACCCCATGGAGAAGCCTGCCAGCCCTTCCAGCTACAAGCAAGACTTCACTAACTCCAAA
CTGCTCATGATGCCTAGTGTGAATAAGAGTTCCCCTCGGCCCGGAGGCCCCTACCTCCAGCCCAGCCATGTGAACCTGCTGAGTCACCAG
CCACCGAGTAACTTGAATCAGAACTCCGCGAATAACCAGGGGTCTGTGCTGGACTACGGCAATACAAAACCCCTTTCTCATTACAAAGCG
GACTGTGGGCAAGGCAGCCCGGGGTCTGGCCAGAGCAAGCCAGCCCTGATGGCTTATCTTCCCCAGCAGCTGTCCCATATAAGTCACGAG
CAGAACTCCCTGTTTCTGATGAAGCCAAAGCCAGGAAATATGCCTTTCCGATCACTGGTTCCACCTGGCCAGGAGCAGAACCCTTCCAGT
GTCCCTGTGCAAGCCCAGGCTACCAGTGTTGGGACCCAGCCGCCTGCCGTGTCCGTGGCCAGCTCCCACAACAGCTCCCCCTATCTCAGC
AGCCAGCAACAGGCCGCTGTAATGAAGCAGCATCAGTTGCTTTTGGACCAACAGAAACAAAGGGAGCAGCAGCAAAAGCATTTACAGCAA
CAGCAGTTCCTTCAGAGGCAACAGCACCTTCTCGCGGAACAGGAGAAGCAACAGTTTCAGCGCCATCTGACCCGCCCACCACCCCAGTAC
CAAGACCCGACACAAGGCAGCTTCCCACAGCAGGTTGGACAGTTCACAGGGTCCTCTGCTGCCGTGCCCGGCATGAACACCTTGGGTCCA
TCCAACTCCAGCTGTCCTCGAGTGTTCCCTCAGGCTGGGAATCTGATGCCAATGGGCCCTGGACATGCTTCAGTTTCCTCTCTCCCCACA
AACTCAGGCCAACAGGACCGGGGTGTGGCTCAGTTCCCTGGCTCCCAAAACATGCCTCAGAGCAGCCTCTATGGCATGGCTTCTGGCATA
ACCCAGATAGTTGCCCAGCCCCCGCCACAGGCCACCAATGGACATGCCCACATTCCACGGCAGACCAACGTGGGCCAGAACACCTCCGTC
TCAGCTGCCTATGGGCAGAACTCTCTGGGAAGCTCTGGCCTCTCCCAGCAGCACAATAAGGGGACCCTGAACCCTGGTTTAACAAAGCCA
CCGGTCCCAAGGGTGTCACCAGCCATGGGAGGCCAGAATTCCTCCTGGCAGCATCAGGGAATGCCGAACCTCAGTGGCCAGACCCCAGGG
AACAGCAACGTGAGTCCCTTCACTGCAGCCTCCAGTTTCCACATGCAGCAGCAGGCCCACCTGAAAATGTCTAGCCCGCAATTCTCCCAG
GCAGTGCCCAACAGGCCCATGGCTCCCATGAGCTCAGCAGCTGCCGTGGGGTCCTTGCTACCCCCAGTGAGTGCACAGCAGAGGACCAGC
GCCCCTGCCCCAGCACCACCCCCAACAGCCCCTCAGCAGGGCTTGCCTGGCCTGAGCCCAGCAGGGCCTGAGCTGGGGGCCTTCAGCCAG
AGCCCTGCCTCACAGATGGGCGGTCGGGCGGGGCTGCACTGCACCCAGGCCTACCCTGTGCGGACCGCGGGCCAGGAGCTGCCTTTTGCC
TATAGCGGGCAGCCAGGTGGCAGTGGGCTCTCTAGTGTGGCTGGACACACCGATCTGATCGACTCCCTGCTGAAGAACAGGACTTCAGAG
GAGTGGATGAGTGATTTGGACGACCTGTTAGGGTCTCAGTAATGGAAGGATTTGTAGTGTTTTTAGTGTTCATTCATCCTATATTTTTAT
TCTCAGATTCAAAGAAAGAGCAACTACTTTGGACCAAAAGCCCATGGCCTGGGGAGCTGGGCAGGTAGAGCCCAAGCTCCAGGTGAGGCC
TGGCCCTGGGCAGGGTCTGTGGCTGCGCCCCTCAGGCCAGCAGTTGAGGTCCATCGGGCTGGCCCCAGCCCATCTGCTGGCATCAGTACC
TGGTGTTGGGACAGCAGGATAGGGTTCTAAAGGTGGTTTTCTATCCAAACGACCAAAAAACCAACAGTAACACCAGTGAAACCCCACACT
GTCGGGCTTATAAAAATCTGTGCCATCATGGTGATTTTATCCAAGACTGCTCCACTTACCCCAGTGCTGGGGACAAGTTTCTGTTGAAAC
TTTAGATAGCAGAATTATTTGCAATTTGTAGCATAGAAAAGATTTTTAAATTTTTTTACAAAAGGTTTTTAAACAGATTAGGGTAGGTGA
TGGTTTAAATCAATTAAGTGGCATTGGAAACCTAGGGTTTCCTTTTGATTAAGAGCCTTTTTTGTTTCTGCTCTTTGTCAGCTTTCAGGG
GAGAAGGAGGCCACTGGAAAATTATTTCCCTAAGTGCAGGCTGTTGACTGCGTATGCCAAAAAGGGACAGGAGGCATGGGATAGCAGGTC
TGGTGACACAGCTAGGGTCTTCCTAGCAGCTCCTCCTCCTCCCTCCCAAGGCCCCCAGGAATCCCTTCCTCCCATGTCCTGGCAGCAGGA
CCCCAGGCTACATATGGAAGGTAGAGATGTGGGGGTCCTGTATCCTGGAGTATTATGTCTCCCCACCTTCTGCAGTTTTCTCTGAACATG
TATGTTGCCCATGGTGGGAGCGTGGTCACTGTGCAGTTGTGCACAGATGTCTTTCCTTTACCGTTGGCCTTTCTGTCTGCCTCTCCTTCC
TCTCTGCAGCCCAAATGGAAAACAATTATTTACTCCATTGGAGGGAAAGGAAGAGTCTTAGAATTCCTAAGGGAACCTTAGCATAAAGGT
TTTGGGGAAGGAGGCCGTAGGCCGGCCCGGAGGAAGCAATTCCACTTGGTTTGACAACTTCTGCCACTCCCATGTCAGATGACTTGCACT
TCTTAAAGAGATTGCTTTATAACACTAAGACATCCTTTCTAAAGATTCAAGTGGACTTGACTAAGCTGAGGGTCCACGAAATAGAATATG
ACATGTGAGCTGTTTTTGGAAAACGAAGATGGAGAGAGCACTTCCCCGTAACGAAAGCAAAGTGGTAAGCACAGGGTGAGACCCTTTTAC
ACAGAATGGTGGAGAGAAAAGAGAATGCTGAAAAGTGGCTCAGATGCAGAGTGTTCTGTGGAGAAACTGCAGCCCCACTTCTGTTTCCCT
GGAGTCTCCCAATGGATCATTCAGGAGTGTCCTATGTGAGAATTGAGCCAAGGAAAATACTCATGCAACCAGCCTGAGTCGCGGTGAGGG
GACGAGAGGTTGTACACACATTGGTAGTTATTTTGCACCAGCAGTGCCTTTCTCACTGGGGGTACTTGGACCCTCAGATCTTCTTTTCTA
ATAGCCATTTGCCACCCCAAGTGGTATGTCGGCCATTTCTCCTTAAAACACCTTCCCTACCTTTCCCATGTACTCAGTTTAGCTCTCAAA
GAAGGGGTGAATCATAAAGCCAGTGAAAATTTCACCCTCTGAGGGAGTTCCCCAATCTGAAGGGGAAGAGGGTGACCTCAGCGGCTTTTC
TCCCAAAAATCGGCTGAAGGCTGGTTGTGGATCCTTGTTCCTCTCCTGACCCCATCTGGCTGCTGCCCCGTCTCCCACCCCTGTCCCCGG
GGCTCGCTGGCCCTGCACTCCGCCTTAGTCCTGGGGCCGGCGACACAGTGGGGGCTCCTCACTTGCTGCAGTGTCATAGCAATAAAATGT
GATTCTTGGGGTCCCCCCAGGGAGCTGCCCATGGCTTTATTTATGAACCTGGTTTTCGGGAGTCAGGGGAGGAGATGACTTTGCTTCTGT
GCACAGCCCCGTCTTCCAGGAGCCACAACTCAGAAGAAAAGGGTGCTCAGACTTTTGTTATACACATTTGCTTTGTGTAAATAAATGTTT
ACAATTTTATATGAAAGATGGAATAAGCGCTAGAGCTTCCAACTGTATATTTTTTACTTTTATAGATTTTAAAACTATGATCCTTTATAT
GTGTGTTTTGGGGGAGCTATGATAAGTTTTATGGCAAACGGTTGGTATTGTTAACTTTTTATTGTCATCAAAAGTTCATAAAAGTCCTAT
TAATCCCCATATTCTTCTACTGCCCTTAACTCTGGTATACACCAAAAAGAAATCTTTACTTTCCTTGTTTTATCATTATAAAAATAAAGT

>4703_4703_1_ANKRD33B-MAML1_ANKRD33B_chr5_10564945_ENST00000296657_MAML1_chr5_179192326_ENST00000292599_length(amino acids)=1033AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRHLHDTVKRNLDSATSPQNGDQQNGYGDLFPGHKKTRREAPLGVAISSNGLPPASPLGQ
SDKPSGADALQSSGKHSLGLDSLNKKRLADSSLHLNGGSNPSESFPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDLNLNEQEWKE
LIEELNRSVPDEDMKDLFNEDFEEKKDPESSGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGG
SQTLFHTSGQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQATPAPAPGQMSTWQQT
GPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKA
DCGQGSPGSGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAVSVASSHNSSPYLS
SQQQAAVMKQHQLLLDQQKQREQQQKHLQQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQDPTQGSFPQQVGQFTGSSAAVPGMNTLGP
SNSSCPRVFPQAGNLMPMGPGHASVSSLPTNSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQATNGHAHIPRQTNVGQNTSV
SAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSSWQHQGMPNLSGQTPGNSNVSPFTAASSFHMQQQAHLKMSSPQFSQ
AVPNRPMAPMSSAAAVGSLLPPVSAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQMGGRAGLHCTQAYPVRTAGQELPFA

--------------------------------------------------------------
>4703_4703_2_ANKRD33B-MAML1_ANKRD33B_chr5_10564945_ENST00000296657_MAML1_chr5_179192327_ENST00000292599_length(transcript)=5511nt_BP=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTC
GAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGCAGCATCGCCTCGGACGACTCTTTCTACCCT
TTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTG
CGCGCCGCCTGCGCCAACAACGTGGGGCTGCTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAAC
GGCAGGCATCTTCATGATACAGTTAAGAGGAATCTTGACAGCGCCACTTCCCCTCAGAATGGCGATCAACAGAATGGCTACGGGGACCTC
TTTCCTGGGCATAAGAAGACTCGCCGGGAGGCCCCTCTGGGAGTTGCCATCTCTTCCAATGGACTGCCTCCAGCCTCCCCCCTCGGTCAG
TCTGACAAGCCTTCTGGAGCCGACGCCCTGCAGTCCAGTGGGAAGCACTCTCTGGGGCTAGACTCTCTCAACAAAAAGCGTCTGGCTGAC
TCCAGCCTTCACTTGAATGGAGGCAGTAACCCCAGTGAGTCATTTCCTCTGAGCCTGAATAAAGAACTGAAGCAGGAGCCTGTCGAAGAC
CTGCCTTGCATGATCACTGGGACTGTCGGCTCCATATCGCAAAGCAACCTCATGCCAGACCTCAACCTTAACGAGCAGGAGTGGAAGGAG
CTCATCGAGGAGCTGAACAGGTCGGTGCCCGATGAAGACATGAAGGACCTGTTTAATGAGGACTTCGAGGAGAAGAAGGACCCAGAGTCT
TCTGGCTCTGCCACACAAACCCCCTTGGCACAGGACATTAATATTAAGACGGAATTCTCTCCAGCAGCCTTTGAGCAAGAACAGTTAGGC
TCTCCACAAGTGAGGGCCGGGTCTGCAGGGCAGACCTTTCTGGGGCCTTCCTCTGCCCCTGTGAGTACAGATTCCCCCAGCCTAGGGGGC
TCCCAAACCTTATTCCACACCTCTGGTCAGCCCCGGGCGGACAATCCCAGTCCAAACCTGATGCCGGCATCAGCCCAGGCCCAGAACGCA
CAAAGAGCCCTTGCAGGTGTGGTATTGCCCAGTCAGGGCCCAGGAGGGGCCTCAGAGCTGTCCTCTGCCCACCAGCTCCAGCAGATCGCT
GCCAAGCAGAAGCGCGAGCAGATGCTCCAGAACCCACAGCAGGCCACCCCGGCACCAGCCCCGGGCCAGATGTCCACATGGCAGCAGACG
GGGCCCTCCCACAGTTCCTTAGATGTCCCTTACCCCATGGAGAAGCCTGCCAGCCCTTCCAGCTACAAGCAAGACTTCACTAACTCCAAA
CTGCTCATGATGCCTAGTGTGAATAAGAGTTCCCCTCGGCCCGGAGGCCCCTACCTCCAGCCCAGCCATGTGAACCTGCTGAGTCACCAG
CCACCGAGTAACTTGAATCAGAACTCCGCGAATAACCAGGGGTCTGTGCTGGACTACGGCAATACAAAACCCCTTTCTCATTACAAAGCG
GACTGTGGGCAAGGCAGCCCGGGGTCTGGCCAGAGCAAGCCAGCCCTGATGGCTTATCTTCCCCAGCAGCTGTCCCATATAAGTCACGAG
CAGAACTCCCTGTTTCTGATGAAGCCAAAGCCAGGAAATATGCCTTTCCGATCACTGGTTCCACCTGGCCAGGAGCAGAACCCTTCCAGT
GTCCCTGTGCAAGCCCAGGCTACCAGTGTTGGGACCCAGCCGCCTGCCGTGTCCGTGGCCAGCTCCCACAACAGCTCCCCCTATCTCAGC
AGCCAGCAACAGGCCGCTGTAATGAAGCAGCATCAGTTGCTTTTGGACCAACAGAAACAAAGGGAGCAGCAGCAAAAGCATTTACAGCAA
CAGCAGTTCCTTCAGAGGCAACAGCACCTTCTCGCGGAACAGGAGAAGCAACAGTTTCAGCGCCATCTGACCCGCCCACCACCCCAGTAC
CAAGACCCGACACAAGGCAGCTTCCCACAGCAGGTTGGACAGTTCACAGGGTCCTCTGCTGCCGTGCCCGGCATGAACACCTTGGGTCCA
TCCAACTCCAGCTGTCCTCGAGTGTTCCCTCAGGCTGGGAATCTGATGCCAATGGGCCCTGGACATGCTTCAGTTTCCTCTCTCCCCACA
AACTCAGGCCAACAGGACCGGGGTGTGGCTCAGTTCCCTGGCTCCCAAAACATGCCTCAGAGCAGCCTCTATGGCATGGCTTCTGGCATA
ACCCAGATAGTTGCCCAGCCCCCGCCACAGGCCACCAATGGACATGCCCACATTCCACGGCAGACCAACGTGGGCCAGAACACCTCCGTC
TCAGCTGCCTATGGGCAGAACTCTCTGGGAAGCTCTGGCCTCTCCCAGCAGCACAATAAGGGGACCCTGAACCCTGGTTTAACAAAGCCA
CCGGTCCCAAGGGTGTCACCAGCCATGGGAGGCCAGAATTCCTCCTGGCAGCATCAGGGAATGCCGAACCTCAGTGGCCAGACCCCAGGG
AACAGCAACGTGAGTCCCTTCACTGCAGCCTCCAGTTTCCACATGCAGCAGCAGGCCCACCTGAAAATGTCTAGCCCGCAATTCTCCCAG
GCAGTGCCCAACAGGCCCATGGCTCCCATGAGCTCAGCAGCTGCCGTGGGGTCCTTGCTACCCCCAGTGAGTGCACAGCAGAGGACCAGC
GCCCCTGCCCCAGCACCACCCCCAACAGCCCCTCAGCAGGGCTTGCCTGGCCTGAGCCCAGCAGGGCCTGAGCTGGGGGCCTTCAGCCAG
AGCCCTGCCTCACAGATGGGCGGTCGGGCGGGGCTGCACTGCACCCAGGCCTACCCTGTGCGGACCGCGGGCCAGGAGCTGCCTTTTGCC
TATAGCGGGCAGCCAGGTGGCAGTGGGCTCTCTAGTGTGGCTGGACACACCGATCTGATCGACTCCCTGCTGAAGAACAGGACTTCAGAG
GAGTGGATGAGTGATTTGGACGACCTGTTAGGGTCTCAGTAATGGAAGGATTTGTAGTGTTTTTAGTGTTCATTCATCCTATATTTTTAT
TCTCAGATTCAAAGAAAGAGCAACTACTTTGGACCAAAAGCCCATGGCCTGGGGAGCTGGGCAGGTAGAGCCCAAGCTCCAGGTGAGGCC
TGGCCCTGGGCAGGGTCTGTGGCTGCGCCCCTCAGGCCAGCAGTTGAGGTCCATCGGGCTGGCCCCAGCCCATCTGCTGGCATCAGTACC
TGGTGTTGGGACAGCAGGATAGGGTTCTAAAGGTGGTTTTCTATCCAAACGACCAAAAAACCAACAGTAACACCAGTGAAACCCCACACT
GTCGGGCTTATAAAAATCTGTGCCATCATGGTGATTTTATCCAAGACTGCTCCACTTACCCCAGTGCTGGGGACAAGTTTCTGTTGAAAC
TTTAGATAGCAGAATTATTTGCAATTTGTAGCATAGAAAAGATTTTTAAATTTTTTTACAAAAGGTTTTTAAACAGATTAGGGTAGGTGA
TGGTTTAAATCAATTAAGTGGCATTGGAAACCTAGGGTTTCCTTTTGATTAAGAGCCTTTTTTGTTTCTGCTCTTTGTCAGCTTTCAGGG
GAGAAGGAGGCCACTGGAAAATTATTTCCCTAAGTGCAGGCTGTTGACTGCGTATGCCAAAAAGGGACAGGAGGCATGGGATAGCAGGTC
TGGTGACACAGCTAGGGTCTTCCTAGCAGCTCCTCCTCCTCCCTCCCAAGGCCCCCAGGAATCCCTTCCTCCCATGTCCTGGCAGCAGGA
CCCCAGGCTACATATGGAAGGTAGAGATGTGGGGGTCCTGTATCCTGGAGTATTATGTCTCCCCACCTTCTGCAGTTTTCTCTGAACATG
TATGTTGCCCATGGTGGGAGCGTGGTCACTGTGCAGTTGTGCACAGATGTCTTTCCTTTACCGTTGGCCTTTCTGTCTGCCTCTCCTTCC
TCTCTGCAGCCCAAATGGAAAACAATTATTTACTCCATTGGAGGGAAAGGAAGAGTCTTAGAATTCCTAAGGGAACCTTAGCATAAAGGT
TTTGGGGAAGGAGGCCGTAGGCCGGCCCGGAGGAAGCAATTCCACTTGGTTTGACAACTTCTGCCACTCCCATGTCAGATGACTTGCACT
TCTTAAAGAGATTGCTTTATAACACTAAGACATCCTTTCTAAAGATTCAAGTGGACTTGACTAAGCTGAGGGTCCACGAAATAGAATATG
ACATGTGAGCTGTTTTTGGAAAACGAAGATGGAGAGAGCACTTCCCCGTAACGAAAGCAAAGTGGTAAGCACAGGGTGAGACCCTTTTAC
ACAGAATGGTGGAGAGAAAAGAGAATGCTGAAAAGTGGCTCAGATGCAGAGTGTTCTGTGGAGAAACTGCAGCCCCACTTCTGTTTCCCT
GGAGTCTCCCAATGGATCATTCAGGAGTGTCCTATGTGAGAATTGAGCCAAGGAAAATACTCATGCAACCAGCCTGAGTCGCGGTGAGGG
GACGAGAGGTTGTACACACATTGGTAGTTATTTTGCACCAGCAGTGCCTTTCTCACTGGGGGTACTTGGACCCTCAGATCTTCTTTTCTA
ATAGCCATTTGCCACCCCAAGTGGTATGTCGGCCATTTCTCCTTAAAACACCTTCCCTACCTTTCCCATGTACTCAGTTTAGCTCTCAAA
GAAGGGGTGAATCATAAAGCCAGTGAAAATTTCACCCTCTGAGGGAGTTCCCCAATCTGAAGGGGAAGAGGGTGACCTCAGCGGCTTTTC
TCCCAAAAATCGGCTGAAGGCTGGTTGTGGATCCTTGTTCCTCTCCTGACCCCATCTGGCTGCTGCCCCGTCTCCCACCCCTGTCCCCGG
GGCTCGCTGGCCCTGCACTCCGCCTTAGTCCTGGGGCCGGCGACACAGTGGGGGCTCCTCACTTGCTGCAGTGTCATAGCAATAAAATGT
GATTCTTGGGGTCCCCCCAGGGAGCTGCCCATGGCTTTATTTATGAACCTGGTTTTCGGGAGTCAGGGGAGGAGATGACTTTGCTTCTGT
GCACAGCCCCGTCTTCCAGGAGCCACAACTCAGAAGAAAAGGGTGCTCAGACTTTTGTTATACACATTTGCTTTGTGTAAATAAATGTTT
ACAATTTTATATGAAAGATGGAATAAGCGCTAGAGCTTCCAACTGTATATTTTTTACTTTTATAGATTTTAAAACTATGATCCTTTATAT
GTGTGTTTTGGGGGAGCTATGATAAGTTTTATGGCAAACGGTTGGTATTGTTAACTTTTTATTGTCATCAAAAGTTCATAAAAGTCCTAT
TAATCCCCATATTCTTCTACTGCCCTTAACTCTGGTATACACCAAAAAGAAATCTTTACTTTCCTTGTTTTATCATTATAAAAATAAAGT

>4703_4703_2_ANKRD33B-MAML1_ANKRD33B_chr5_10564945_ENST00000296657_MAML1_chr5_179192327_ENST00000292599_length(amino acids)=1033AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRHLHDTVKRNLDSATSPQNGDQQNGYGDLFPGHKKTRREAPLGVAISSNGLPPASPLGQ
SDKPSGADALQSSGKHSLGLDSLNKKRLADSSLHLNGGSNPSESFPLSLNKELKQEPVEDLPCMITGTVGSISQSNLMPDLNLNEQEWKE
LIEELNRSVPDEDMKDLFNEDFEEKKDPESSGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGPSSAPVSTDSPSLGG
SQTLFHTSGQPRADNPSPNLMPASAQAQNAQRALAGVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQATPAPAPGQMSTWQQT
GPSHSSLDVPYPMEKPASPSSYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHVNLLSHQPPSNLNQNSANNQGSVLDYGNTKPLSHYKA
DCGQGSPGSGQSKPALMAYLPQQLSHISHEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVQAQATSVGTQPPAVSVASSHNSSPYLS
SQQQAAVMKQHQLLLDQQKQREQQQKHLQQQQFLQRQQHLLAEQEKQQFQRHLTRPPPQYQDPTQGSFPQQVGQFTGSSAAVPGMNTLGP
SNSSCPRVFPQAGNLMPMGPGHASVSSLPTNSGQQDRGVAQFPGSQNMPQSSLYGMASGITQIVAQPPPQATNGHAHIPRQTNVGQNTSV
SAAYGQNSLGSSGLSQQHNKGTLNPGLTKPPVPRVSPAMGGQNSSWQHQGMPNLSGQTPGNSNVSPFTAASSFHMQQQAHLKMSSPQFSQ
AVPNRPMAPMSSAAAVGSLLPPVSAQQRTSAPAPAPPPTAPQQGLPGLSPAGPELGAFSQSPASQMGGRAGLHCTQAYPVRTAGQELPFA

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Fusion Gene PPI Analysis for ANKRD33B-MAML1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD33B-MAML1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD33B-MAML1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource