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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD44-TTLL5 (FusionGDB2 ID:4746)

Fusion Gene Summary for ANKRD44-TTLL5

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD44-TTLL5
Fusion gene ID: 4746
HgeneTgene
Gene symbol

ANKRD44

TTLL5

Gene ID

91526

254173

Gene nameankyrin repeat domain 44tubulin tyrosine ligase like 10
SynonymsPP6-ARS-BTTLL5
Cytomap

2q33.1

1p36.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit Bankyrin repeat domain-containing protein 44serine/threonine-protein phosphatase 6 regulatory subunit ARS-Binactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000409153, ENST00000409919, 
ENST00000539527, ENST00000282272, 
ENST00000328737, ENST00000337207, 
ENST00000450567, ENST00000477852, 
ENST00000286650, ENST00000298832, 
ENST00000554510, ENST00000555422, 
ENST00000556893, ENST00000556977, 
ENST00000557636, 
Fusion gene scores* DoF score11 X 6 X 6=39619 X 18 X 11=3762
# samples 1124
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3762*10)=-3.97039353791468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD44 [Title/Abstract] AND TTLL5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD44(198175301)-TTLL5(76286349), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTTLL5

GO:0018094

protein polyglycylation

19524510


check buttonFusion gene breakpoints across ANKRD44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TTLL5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer145NANKRD44chr2

198175301

-TTLL5chr14

76286349

+


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Fusion Gene ORF analysis for ANKRD44-TTLL5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409153ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409153ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409153ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409153ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409153ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409153ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409919ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409919ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409919ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409919ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409919ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5CDS-intronENST00000409919ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5UTR-3CDSENST00000539527ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5UTR-intronENST00000539527ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5UTR-intronENST00000539527ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5UTR-intronENST00000539527ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5UTR-intronENST00000539527ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5UTR-intronENST00000539527ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
5UTR-intronENST00000539527ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
In-frameENST00000409153ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
In-frameENST00000409919ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-3CDSENST00000282272ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-3CDSENST00000328737ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-3CDSENST00000337207ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-3CDSENST00000450567ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-3CDSENST00000477852ENST00000557636ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000282272ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000282272ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000282272ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000282272ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000282272ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000282272ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000328737ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000328737ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000328737ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000328737ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000328737ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000328737ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000337207ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000337207ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000337207ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000337207ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000337207ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000337207ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000450567ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000450567ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000450567ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000450567ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000450567ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000450567ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000477852ENST00000286650ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000477852ENST00000298832ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000477852ENST00000554510ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000477852ENST00000555422ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000477852ENST00000556893ANKRD44chr2

198175301

-TTLL5chr14

76286349

+
intron-intronENST00000477852ENST00000556977ANKRD44chr2

198175301

-TTLL5chr14

76286349

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409153ANKRD44chr2198175301-ENST00000557636TTLL5chr1476286349+94721096839247
ENST00000409919ANKRD44chr2198175301-ENST00000557636TTLL5chr1476286349+94721096839247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409153ENST00000557636ANKRD44chr2198175301-TTLL5chr1476286349+0.032179680.96782035
ENST00000409919ENST00000557636ANKRD44chr2198175301-TTLL5chr1476286349+0.032179680.96782035

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Fusion Genomic Features for ANKRD44-TTLL5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD44chr2198175301-TTLL5chr1476286349+1.28E-050.9999871
ANKRD44chr2198175301-TTLL5chr1476286349+1.28E-050.9999871

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ANKRD44-TTLL5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:198175301/chr14:76286349)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTLL5chr2:198175301chr14:76286349ENST00000286650010552_5570270.0Compositional biasNote=Poly-Arg
TgeneTTLL5chr2:198175301chr14:76286349ENST00000286650010582_5900270.0Compositional biasNote=Poly-Glu
TgeneTTLL5chr2:198175301chr14:76286349ENST00000286650010776_7800270.0Compositional biasNote=Poly-Glu
TgeneTTLL5chr2:198175301chr14:76286349ENST00000286650010827_8300270.0Compositional biasNote=Poly-Asn
TgeneTTLL5chr2:198175301chr14:76286349ENST000005568931217776_780608818.0Compositional biasNote=Poly-Glu
TgeneTTLL5chr2:198175301chr14:76286349ENST000005568931217827_830608818.0Compositional biasNote=Poly-Asn
TgeneTTLL5chr2:198175301chr14:76286349ENST0000028665001062_4070270.0DomainTTL
TgeneTTLL5chr2:198175301chr14:76286349ENST00000286650010208_2110270.0Nucleotide bindingATP binding
TgeneTTLL5chr2:198175301chr14:76286349ENST00000286650010378_4880270.0Regionc-MTBD region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126106_1350920.0RepeatNote=ANK 4
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126139_1680920.0RepeatNote=ANK 5
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126172_2010920.0RepeatNote=ANK 6
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126205_2340920.0RepeatNote=ANK 7
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126238_2670920.0RepeatNote=ANK 8
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126271_3010920.0RepeatNote=ANK 9
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126305_3340920.0RepeatNote=ANK 10
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126338_3670920.0RepeatNote=ANK 11
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126371_4000920.0RepeatNote=ANK 12
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126404_4330920.0RepeatNote=ANK 13
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-12640_690920.0RepeatNote=ANK 2
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126437_4660920.0RepeatNote=ANK 14
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126470_4980920.0RepeatNote=ANK 15
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126531_5610920.0RepeatNote=ANK 16
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126566_5950920.0RepeatNote=ANK 17
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126599_6280920.0RepeatNote=ANK 18
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126633_6620920.0RepeatNote=ANK 19
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126669_6980920.0RepeatNote=ANK 20
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126702_7310920.0RepeatNote=ANK 21
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126735_7640920.0RepeatNote=ANK 22
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-12673_1020920.0RepeatNote=ANK 3
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126771_8000920.0RepeatNote=ANK 23
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-1267_360920.0RepeatNote=ANK 1
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126803_8320920.0RepeatNote=ANK 24
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126838_8670920.0RepeatNote=ANK 25
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126871_9010920.0RepeatNote=ANK 26
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126905_9340920.0RepeatNote=ANK 27
HgeneANKRD44chr2:198175301chr14:76286349ENST00000328737-126941_9700920.0RepeatNote=ANK 28
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116106_1359580.0RepeatNote=ANK 4
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116139_1689580.0RepeatNote=ANK 5
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116172_2019580.0RepeatNote=ANK 6
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116205_2349580.0RepeatNote=ANK 7
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116238_2679580.0RepeatNote=ANK 8
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116271_3019580.0RepeatNote=ANK 9
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116305_3349580.0RepeatNote=ANK 10
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116338_3679580.0RepeatNote=ANK 11
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116371_4009580.0RepeatNote=ANK 12
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116404_4339580.0RepeatNote=ANK 13
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-11640_699580.0RepeatNote=ANK 2
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116437_4669580.0RepeatNote=ANK 14
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116470_4989580.0RepeatNote=ANK 15
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116531_5619580.0RepeatNote=ANK 16
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116566_5959580.0RepeatNote=ANK 17
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116599_6289580.0RepeatNote=ANK 18
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116633_6629580.0RepeatNote=ANK 19
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116669_6989580.0RepeatNote=ANK 20
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116702_7319580.0RepeatNote=ANK 21
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116735_7649580.0RepeatNote=ANK 22
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-11673_1029580.0RepeatNote=ANK 3
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116771_8009580.0RepeatNote=ANK 23
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-1167_369580.0RepeatNote=ANK 1
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116803_8329580.0RepeatNote=ANK 24
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116838_8679580.0RepeatNote=ANK 25
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116871_9019580.0RepeatNote=ANK 26
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116905_9349580.0RepeatNote=ANK 27
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409153-116941_9709580.0RepeatNote=ANK 28
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110106_1359368.0RepeatNote=ANK 4
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110139_1689368.0RepeatNote=ANK 5
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110172_2019368.0RepeatNote=ANK 6
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110205_2349368.0RepeatNote=ANK 7
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110238_2679368.0RepeatNote=ANK 8
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110271_3019368.0RepeatNote=ANK 9
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110305_3349368.0RepeatNote=ANK 10
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110338_3679368.0RepeatNote=ANK 11
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110371_4009368.0RepeatNote=ANK 12
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110404_4339368.0RepeatNote=ANK 13
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-11040_699368.0RepeatNote=ANK 2
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110437_4669368.0RepeatNote=ANK 14
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110470_4989368.0RepeatNote=ANK 15
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110531_5619368.0RepeatNote=ANK 16
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110566_5959368.0RepeatNote=ANK 17
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110599_6289368.0RepeatNote=ANK 18
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110633_6629368.0RepeatNote=ANK 19
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110669_6989368.0RepeatNote=ANK 20
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110702_7319368.0RepeatNote=ANK 21
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110735_7649368.0RepeatNote=ANK 22
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-11073_1029368.0RepeatNote=ANK 3
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110771_8009368.0RepeatNote=ANK 23
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-1107_369368.0RepeatNote=ANK 1
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110803_8329368.0RepeatNote=ANK 24
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110838_8679368.0RepeatNote=ANK 25
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110871_9019368.0RepeatNote=ANK 26
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110905_9349368.0RepeatNote=ANK 27
HgeneANKRD44chr2:198175301chr14:76286349ENST00000409919-110941_9709368.0RepeatNote=ANK 28
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125106_1350920.0RepeatNote=ANK 4
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125139_1680920.0RepeatNote=ANK 5
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125172_2010920.0RepeatNote=ANK 6
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125205_2340920.0RepeatNote=ANK 7
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125238_2670920.0RepeatNote=ANK 8
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125271_3010920.0RepeatNote=ANK 9
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125305_3340920.0RepeatNote=ANK 10
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125338_3670920.0RepeatNote=ANK 11
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125371_4000920.0RepeatNote=ANK 12
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125404_4330920.0RepeatNote=ANK 13
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-12540_690920.0RepeatNote=ANK 2
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125437_4660920.0RepeatNote=ANK 14
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125470_4980920.0RepeatNote=ANK 15
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125531_5610920.0RepeatNote=ANK 16
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125566_5950920.0RepeatNote=ANK 17
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125599_6280920.0RepeatNote=ANK 18
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125633_6620920.0RepeatNote=ANK 19
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125669_6980920.0RepeatNote=ANK 20
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125702_7310920.0RepeatNote=ANK 21
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125735_7640920.0RepeatNote=ANK 22
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-12573_1020920.0RepeatNote=ANK 3
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125771_8000920.0RepeatNote=ANK 23
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-1257_360920.0RepeatNote=ANK 1
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125803_8320920.0RepeatNote=ANK 24
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125838_8670920.0RepeatNote=ANK 25
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125871_9010920.0RepeatNote=ANK 26
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125905_9340920.0RepeatNote=ANK 27
HgeneANKRD44chr2:198175301chr14:76286349ENST00000450567-125941_9700920.0RepeatNote=ANK 28
TgeneTTLL5chr2:198175301chr14:76286349ENST000002988322632552_55710571282.0Compositional biasNote=Poly-Arg
TgeneTTLL5chr2:198175301chr14:76286349ENST000002988322632582_59010571282.0Compositional biasNote=Poly-Glu
TgeneTTLL5chr2:198175301chr14:76286349ENST000002988322632776_78010571282.0Compositional biasNote=Poly-Glu
TgeneTTLL5chr2:198175301chr14:76286349ENST000002988322632827_83010571282.0Compositional biasNote=Poly-Asn
TgeneTTLL5chr2:198175301chr14:76286349ENST000005568931217552_557608818.0Compositional biasNote=Poly-Arg
TgeneTTLL5chr2:198175301chr14:76286349ENST000005568931217582_590608818.0Compositional biasNote=Poly-Glu
TgeneTTLL5chr2:198175301chr14:76286349ENST00000298832263262_40710571282.0DomainTTL
TgeneTTLL5chr2:198175301chr14:76286349ENST00000556893121762_407608818.0DomainTTL
TgeneTTLL5chr2:198175301chr14:76286349ENST000002988322632208_21110571282.0Nucleotide bindingATP binding
TgeneTTLL5chr2:198175301chr14:76286349ENST000005568931217208_211608818.0Nucleotide bindingATP binding
TgeneTTLL5chr2:198175301chr14:76286349ENST000002988322632378_48810571282.0Regionc-MTBD region
TgeneTTLL5chr2:198175301chr14:76286349ENST000005568931217378_488608818.0Regionc-MTBD region


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Fusion Gene Sequence for ANKRD44-TTLL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4746_4746_1_ANKRD44-TTLL5_ANKRD44_chr2_198175301_ENST00000409153_TTLL5_chr14_76286349_ENST00000557636_length(transcript)=947nt_BP=210nt
ACTAGCCAGTGTCAGCCTCTCGGCGGGAGGAGGCGGCGGCGGAGGAGGAGCAGGGGGAGGGCTGTCAAATTCGGGAGCCAGATTTTTTCC
CTTCTCCTGGCAATCCCTTCCGCTTCCCCGGCTCCCGGCGTGACATCTGCGGGCCGGGGACCTGCATGTGTGTGCGCGCGAAGGAGCGGA
AGAATGGCAGTGCTCAAACTCACCGACCAGGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCA
ACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGA
AGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCAC
AAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGAC
CAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGA
ATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCC
AAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTAT
TTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCT

>4746_4746_1_ANKRD44-TTLL5_ANKRD44_chr2_198175301_ENST00000409153_TTLL5_chr14_76286349_ENST00000557636_length(amino acids)=247AA_BP=38
MAIPSASPAPGVTSAGRGPACVCARRSGRMAVLKLTDQVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSR
SLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRIS

--------------------------------------------------------------
>4746_4746_2_ANKRD44-TTLL5_ANKRD44_chr2_198175301_ENST00000409919_TTLL5_chr14_76286349_ENST00000557636_length(transcript)=947nt_BP=210nt
ACTAGCCAGTGTCAGCCTCTCGGCGGGAGGAGGCGGCGGCGGAGGAGGAGCAGGGGGAGGGCTGTCAAATTCGGGAGCCAGATTTTTTCC
CTTCTCCTGGCAATCCCTTCCGCTTCCCCGGCTCCCGGCGTGACATCTGCGGGCCGGGGACCTGCATGTGTGTGCGCGCGAAGGAGCGGA
AGAATGGCAGTGCTCAAACTCACCGACCAGGTAACAAACCTGAATTTGGCAACTGGCATCATAAACAGAAGCAGTGCTTCAGCTCCCCCA
ACCCTCCGACCCATCATCAGTCCTAGTGGCCCGACATGGTCTACACAGTCAGACCCCCAAGCTCCCGAGAATCACTCCAGCTCTCCTGGA
AGCAGGAGCCTGCAGACAGGGGGATTTGCCTGGGAAGGAGAAGTAGAAAACAACGTGTACAGCCAGGCTACAGGGGTGGTCCCCCAGCAC
AAGTATCACCCCACAGCAGGCAGCTATCAGCTTCAATTTGCCCTGCAGCAACTTGAACAACAAAAACTTCAGTCCCGGCAGCTCCTGGAC
CAGAGTCGAGCCCGGCACCAGGCAATCTTTGGCAGCCAGACACTACCTAACTCCAATTTATGGACAATGAATAATGGTGCAGGTTGTAGA
ATTTCCAGTGCCACAGCTAGTGGCCAGAAGCCAACCACTCTGCCACAAAAAGTGGTACCACCTCCAAGTTCTTGCGCCTCCCTGGTTCCC
AAACCCCCACCCAACCACGAACAAGTGCTCAGAAGGGCAACATCCCAGAAAGCTTCCAATACCCGCTTCAGATCCTCCTTTCAAAACTAT
TTGTGGTATTTCTTCCAAGCAGTCAGCTGAACTGAGGACGACAGCCTACAAACAACTACATGCATCTGAACTGTCTCTTGTAAATGAGCT

>4746_4746_2_ANKRD44-TTLL5_ANKRD44_chr2_198175301_ENST00000409919_TTLL5_chr14_76286349_ENST00000557636_length(amino acids)=247AA_BP=38
MAIPSASPAPGVTSAGRGPACVCARRSGRMAVLKLTDQVTNLNLATGIINRSSASAPPTLRPIISPSGPTWSTQSDPQAPENHSSSPGSR
SLQTGGFAWEGEVENNVYSQATGVVPQHKYHPTAGSYQLQFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRIS

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Fusion Gene PPI Analysis for ANKRD44-TTLL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD44-TTLL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD44-TTLL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource