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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABL1-BCR (FusionGDB2 ID:478)

Fusion Gene Summary for ABL1-BCR

Fusion gene summary

Fusion gene information	Fusion gene name: ABL1-BCR
	Fusion gene ID: 478
		Hgene	Tgene
	Gene symbol	ABL1	BCR
	Gene ID	25	613
	Gene name	ABL proto-oncogene 1, non-receptor tyrosine kinase	BCR activator of RhoGEF and GTPase
	Synonyms	ABL\|BCR-ABL\|CHDSKM\|JTK7\|bcr/abl\|c-ABL\|c-ABL1\|p150\|v-abl	ALL\|BCR1\|CML\|D22S11\|D22S662\|PHL
	Cytomap	9q34.12	22q11.23
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1truncated	breakpoint cluster region proteinBCR, RhoGEF and GTPase activating proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26
	Modification date	20200327	20200313
	UniProtAcc	P00519	P11274
	Ensembl transtripts involved in fusion gene	ENST00000318560,	ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990,
Fusion gene scores	* DoF score	21 X 55 X 13=15015	15 X 58 X 7=6090
	# samples	68	61
	** MAII score	log2(68/15015*10)=-4.46472591830681 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(61/6090*10)=-3.31956108034345 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABL1 [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract] Expression of the ABL-BCR Fusion Gene in Philadelphia-Positive Acute Lymphoblastic Leukemia (pmid: 8490164) A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9 (pmid: 9809034)
Most frequent breakpoint	BCR(23632600)-ABL1(133729451), # samples:12 ABL1(133589842)-BCR(23634728), # samples:6
Anticipated loss of major functional domain due to fusion event.	BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BCR-ABL1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABL1	GO:0006974	cellular response to DNA damage stimulus	15657060
Hgene	ABL1	GO:0006975	DNA damage induced protein phosphorylation	18280240
Hgene	ABL1	GO:0018108	peptidyl-tyrosine phosphorylation	7590236\|9144171\|10713049\|11121037
Hgene	ABL1	GO:0038083	peptidyl-tyrosine autophosphorylation	10518561
Hgene	ABL1	GO:0042770	signal transduction in response to DNA damage	9037071\|15657060
Hgene	ABL1	GO:0043065	positive regulation of apoptotic process	9037071
Hgene	ABL1	GO:0046777	protein autophosphorylation	10713049
Hgene	ABL1	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	15657060
Hgene	ABL1	GO:0051353	positive regulation of oxidoreductase activity	12893824
Hgene	ABL1	GO:0051444	negative regulation of ubiquitin-protein transferase activity	20823226
Hgene	ABL1	GO:0070301	cellular response to hydrogen peroxide	10713049
Hgene	ABL1	GO:0071103	DNA conformation change	9558345
Hgene	ABL1	GO:0071901	negative regulation of protein serine/threonine kinase activity	11121037
Hgene	ABL1	GO:1990051	activation of protein kinase C activity	10713049
Hgene	ABL1	GO:2001020	regulation of response to DNA damage stimulus	9461559
Tgene	BCR	GO:0090630	activation of GTPase activity	7479768

Fusion gene breakpoints across ABL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BCR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LAML	TCGA-AB-2817-03A	ABL1	chr9	133589842	-	BCR	chr22	23595986	+
ChimerDB4	LAML	TCGA-AB-2901-03A	ABL1	chr9	133589842	-	BCR	chr22	23634728	+
ChimerDB4	LAML	TCGA-AB-2901_61GABAAXX_2	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
ChimerDB4	LAML	TCGA-AB-2901_700FEAAXX_2	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
ChimerDB4	LAML	TCGA-AB-2941-03A	ABL1	chr9	133589842	-	BCR	chr22	23634728	+
ChimerDB4	LAML	TCGA-AB-2941_703RKAAXX_5	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
ChimerDB4	LAML	TCGA-AB-2941_70417AAXX_8	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
ChimerDB4	LAML	TCGA-AB-2941	ABL1	chr9	133589842	+	BCR	chr22	23634727	+
ChiTaRS5.0	N/A	FN869132	ABL1	chr9	133661281	+	BCR	chr22	23329601	+
ChiTaRS5.0	N/A	FN869133	ABL1	chr9	133665065	+	BCR	chr22	23632278	+
ChiTaRS5.0	N/A	FN869135	ABL1	chr9	133662856	+	BCR	chr22	23634037	+
ChiTaRS5.0	N/A	FN869136	ABL1	chr9	133601712	+	BCR	chr22	23634625	+
ChiTaRS5.0	N/A	FN869138	ABL1	chr9	133640438	+	BCR	chr22	23632376	+
ChiTaRS5.0	N/A	FN869140	ABL1	chr9	133608655	+	BCR	chr22	23632746	+
ChiTaRS5.0	N/A	FN869141	ABL1	chr9	133728433	+	BCR	chr22	23633949	+
ChiTaRS5.0	N/A	FN869142	ABL1	chr9	133707481	+	BCR	chr22	23633310	+
ChiTaRS5.0	N/A	FN869143	ABL1	chr9	133720322	+	BCR	chr22	23634652	+
ChiTaRS5.0	N/A	FN869144	ABL1	chr9	133718268	+	BCR	chr22	23632030	+
ChiTaRS5.0	N/A	FN869145	ABL1	chr9	133688104	+	BCR	chr22	23631893	+
ChiTaRS5.0	N/A	FN869146	ABL1	chr9	133710292	+	BCR	chr22	23632310	+
ChiTaRS5.0	N/A	FN869147	ABL1	chr9	133659980	+	BCR	chr22	23632150	+
ChiTaRS5.0	N/A	FN869148	ABL1	chr9	133637880	+	BCR	chr22	23632063	+
ChiTaRS5.0	N/A	FN869149	ABL1	chr9	133648542	+	BCR	chr22	23631641	+
ChiTaRS5.0	N/A	FN869151	ABL1	chr9	133656687	+	BCR	chr22	23632085	+
ChiTaRS5.0	N/A	FN869152	ABL1	chr9	133717558	+	BCR	chr22	23632009	+
ChiTaRS5.0	N/A	FN869153	ABL1	chr9	133605484	+	BCR	chr22	23594824	+
ChiTaRS5.0	N/A	FN869156	ABL1	chr9	133619871	+	BCR	chr22	23371217	+
ChiTaRS5.0	N/A	FN869157	ABL1	chr9	133657429	+	BCR	chr22	23632936	+
ChiTaRS5.0	N/A	FN869159	ABL1	chr9	133677898	+	BCR	chr22	23631846	+
ChiTaRS5.0	N/A	FN869160	ABL1	chr9	133640782	+	BCR	chr22	23634788	+
ChiTaRS5.0	N/A	FN869161	ABL1	chr9	133721863	+	BCR	chr22	23632679	+
ChiTaRS5.0	N/A	FN869162	ABL1	chr9	133708503	+	BCR	chr22	23632334	+
ChiTaRS5.0	N/A	FN869163	ABL1	chr9	133631737	+	BCR	chr22	23631966	+
ChiTaRS5.0	N/A	FN869164	ABL1	chr9	133632336	+	BCR	chr22	23632430	+
ChiTaRS5.0	N/A	FN869165	ABL1	chr9	133714309	+	BCR	chr22	23634313	+
ChiTaRS5.0	N/A	FN869166	ABL1	chr9	133723232	+	BCR	chr22	23633596	+
ChiTaRS5.0	N/A	FN869168	ABL1	chr9	133605256	+	BCR	chr22	23383190	+
ChiTaRS5.0	N/A	FN869169	ABL1	chr9	133593182	+	BCR	chr22	23355254	+
ChiTaRS5.0	N/A	FN869171	ABL1	chr9	133597121	+	BCR	chr22	23632824	+
ChiTaRS5.0	N/A	FN869172	ABL1	chr9	133610029	+	BCR	chr22	23631563	+
ChiTaRS5.0	N/A	FN869173	ABL1	chr9	133649377	+	BCR	chr22	23631757	+
ChiTaRS5.0	N/A	FN869174	ABL1	chr9	133656666	+	BCR	chr22	23632342	+
ChiTaRS5.0	N/A	FN869175	ABL1	chr9	133680063	+	BCR	chr22	23634651	+
ChiTaRS5.0	N/A	FN869176	ABL1	chr9	133591406	+	BCR	chr22	23632030	+
ChiTaRS5.0	N/A	JQ425240	ABL1	chr9	133686164	+	BCR	chr22	23632728	+
ChiTaRS5.0	N/A	JQ425243	ABL1	chr9	133609600	+	BCR	chr22	23633410	+
ChiTaRS5.0	N/A	JQ425245	ABL1	chr9	133614221	+	BCR	chr22	23632569	+
ChiTaRS5.0	N/A	JQ425248	ABL1	chr9	133715193	+	BCR	chr22	23632419	+
ChiTaRS5.0	N/A	JQ425250	ABL1	chr9	133651594	+	BCR	chr22	23633431	+
ChiTaRS5.0	N/A	JQ425252	ABL1	chr9	133611321	+	BCR	chr22	23632429	+

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Fusion Gene ORF analysis for ABL1-BCR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000318560	ENST00000305877	ABL1	chr9	133589842	-	BCR	chr22	23595986	+
intron-3CDS	ENST00000318560	ENST00000305877	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
intron-3CDS	ENST00000318560	ENST00000305877	ABL1	chr9	133589842	+	BCR	chr22	23634727	+
intron-3CDS	ENST00000318560	ENST00000305877	ABL1	chr9	133640782	+	BCR	chr22	23634788	+
intron-3CDS	ENST00000318560	ENST00000305877	ABL1	chr9	133649377	+	BCR	chr22	23631757	+
intron-3CDS	ENST00000318560	ENST00000305877	ABL1	chr9	133614221	+	BCR	chr22	23632569	+
intron-3CDS	ENST00000318560	ENST00000359540	ABL1	chr9	133589842	-	BCR	chr22	23595986	+
intron-3CDS	ENST00000318560	ENST00000359540	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
intron-3CDS	ENST00000318560	ENST00000359540	ABL1	chr9	133589842	+	BCR	chr22	23634727	+
intron-3CDS	ENST00000318560	ENST00000359540	ABL1	chr9	133640782	+	BCR	chr22	23634788	+
intron-3CDS	ENST00000318560	ENST00000359540	ABL1	chr9	133649377	+	BCR	chr22	23631757	+
intron-3CDS	ENST00000318560	ENST00000359540	ABL1	chr9	133614221	+	BCR	chr22	23632569	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133661281	+	BCR	chr22	23329601	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133665065	+	BCR	chr22	23632278	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133662856	+	BCR	chr22	23634037	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133601712	+	BCR	chr22	23634625	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133640438	+	BCR	chr22	23632376	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133608655	+	BCR	chr22	23632746	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133728433	+	BCR	chr22	23633949	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133707481	+	BCR	chr22	23633310	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133720322	+	BCR	chr22	23634652	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133718268	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133688104	+	BCR	chr22	23631893	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133710292	+	BCR	chr22	23632310	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133659980	+	BCR	chr22	23632150	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133637880	+	BCR	chr22	23632063	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133648542	+	BCR	chr22	23631641	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133656687	+	BCR	chr22	23632085	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133717558	+	BCR	chr22	23632009	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133605484	+	BCR	chr22	23594824	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133619871	+	BCR	chr22	23371217	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133657429	+	BCR	chr22	23632936	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133677898	+	BCR	chr22	23631846	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133721863	+	BCR	chr22	23632679	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133708503	+	BCR	chr22	23632334	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133631737	+	BCR	chr22	23631966	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133632336	+	BCR	chr22	23632430	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133714309	+	BCR	chr22	23634313	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133723232	+	BCR	chr22	23633596	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133605256	+	BCR	chr22	23383190	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133593182	+	BCR	chr22	23355254	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133597121	+	BCR	chr22	23632824	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133610029	+	BCR	chr22	23631563	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133656666	+	BCR	chr22	23632342	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133680063	+	BCR	chr22	23634651	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133591406	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133686164	+	BCR	chr22	23632728	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133609600	+	BCR	chr22	23633410	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133715193	+	BCR	chr22	23632419	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133651594	+	BCR	chr22	23633431	+
intron-intron	ENST00000318560	ENST00000305877	ABL1	chr9	133611321	+	BCR	chr22	23632429	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133661281	+	BCR	chr22	23329601	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133665065	+	BCR	chr22	23632278	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133662856	+	BCR	chr22	23634037	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133601712	+	BCR	chr22	23634625	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133640438	+	BCR	chr22	23632376	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133608655	+	BCR	chr22	23632746	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133728433	+	BCR	chr22	23633949	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133707481	+	BCR	chr22	23633310	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133720322	+	BCR	chr22	23634652	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133718268	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133688104	+	BCR	chr22	23631893	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133710292	+	BCR	chr22	23632310	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133659980	+	BCR	chr22	23632150	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133637880	+	BCR	chr22	23632063	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133648542	+	BCR	chr22	23631641	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133656687	+	BCR	chr22	23632085	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133717558	+	BCR	chr22	23632009	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133605484	+	BCR	chr22	23594824	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133619871	+	BCR	chr22	23371217	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133657429	+	BCR	chr22	23632936	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133677898	+	BCR	chr22	23631846	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133721863	+	BCR	chr22	23632679	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133708503	+	BCR	chr22	23632334	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133631737	+	BCR	chr22	23631966	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133632336	+	BCR	chr22	23632430	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133714309	+	BCR	chr22	23634313	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133723232	+	BCR	chr22	23633596	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133605256	+	BCR	chr22	23383190	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133593182	+	BCR	chr22	23355254	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133597121	+	BCR	chr22	23632824	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133610029	+	BCR	chr22	23631563	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133656666	+	BCR	chr22	23632342	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133680063	+	BCR	chr22	23634651	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133591406	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133686164	+	BCR	chr22	23632728	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133609600	+	BCR	chr22	23633410	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133715193	+	BCR	chr22	23632419	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133651594	+	BCR	chr22	23633431	+
intron-intron	ENST00000318560	ENST00000359540	ABL1	chr9	133611321	+	BCR	chr22	23632429	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133589842	-	BCR	chr22	23595986	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133589842	+	BCR	chr22	23634727	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133661281	+	BCR	chr22	23329601	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133665065	+	BCR	chr22	23632278	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133662856	+	BCR	chr22	23634037	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133601712	+	BCR	chr22	23634625	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133640438	+	BCR	chr22	23632376	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133608655	+	BCR	chr22	23632746	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133728433	+	BCR	chr22	23633949	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133707481	+	BCR	chr22	23633310	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133720322	+	BCR	chr22	23634652	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133718268	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133688104	+	BCR	chr22	23631893	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133710292	+	BCR	chr22	23632310	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133659980	+	BCR	chr22	23632150	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133637880	+	BCR	chr22	23632063	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133648542	+	BCR	chr22	23631641	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133656687	+	BCR	chr22	23632085	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133717558	+	BCR	chr22	23632009	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133605484	+	BCR	chr22	23594824	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133619871	+	BCR	chr22	23371217	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133657429	+	BCR	chr22	23632936	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133677898	+	BCR	chr22	23631846	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133640782	+	BCR	chr22	23634788	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133721863	+	BCR	chr22	23632679	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133708503	+	BCR	chr22	23632334	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133631737	+	BCR	chr22	23631966	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133632336	+	BCR	chr22	23632430	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133714309	+	BCR	chr22	23634313	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133723232	+	BCR	chr22	23633596	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133605256	+	BCR	chr22	23383190	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133593182	+	BCR	chr22	23355254	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133597121	+	BCR	chr22	23632824	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133610029	+	BCR	chr22	23631563	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133649377	+	BCR	chr22	23631757	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133656666	+	BCR	chr22	23632342	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133680063	+	BCR	chr22	23634651	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133591406	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133686164	+	BCR	chr22	23632728	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133609600	+	BCR	chr22	23633410	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133614221	+	BCR	chr22	23632569	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133715193	+	BCR	chr22	23632419	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133651594	+	BCR	chr22	23633431	+
intron-intron	ENST00000318560	ENST00000398512	ABL1	chr9	133611321	+	BCR	chr22	23632429	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133589842	-	BCR	chr22	23595986	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133589842	+	BCR	chr22	23634728	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133589842	+	BCR	chr22	23634727	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133661281	+	BCR	chr22	23329601	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133665065	+	BCR	chr22	23632278	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133662856	+	BCR	chr22	23634037	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133601712	+	BCR	chr22	23634625	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133640438	+	BCR	chr22	23632376	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133608655	+	BCR	chr22	23632746	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133728433	+	BCR	chr22	23633949	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133707481	+	BCR	chr22	23633310	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133720322	+	BCR	chr22	23634652	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133718268	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133688104	+	BCR	chr22	23631893	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133710292	+	BCR	chr22	23632310	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133659980	+	BCR	chr22	23632150	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133637880	+	BCR	chr22	23632063	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133648542	+	BCR	chr22	23631641	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133656687	+	BCR	chr22	23632085	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133717558	+	BCR	chr22	23632009	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133605484	+	BCR	chr22	23594824	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133619871	+	BCR	chr22	23371217	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133657429	+	BCR	chr22	23632936	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133677898	+	BCR	chr22	23631846	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133640782	+	BCR	chr22	23634788	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133721863	+	BCR	chr22	23632679	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133708503	+	BCR	chr22	23632334	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133631737	+	BCR	chr22	23631966	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133632336	+	BCR	chr22	23632430	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133714309	+	BCR	chr22	23634313	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133723232	+	BCR	chr22	23633596	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133605256	+	BCR	chr22	23383190	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133593182	+	BCR	chr22	23355254	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133597121	+	BCR	chr22	23632824	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133610029	+	BCR	chr22	23631563	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133649377	+	BCR	chr22	23631757	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133656666	+	BCR	chr22	23632342	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133680063	+	BCR	chr22	23634651	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133591406	+	BCR	chr22	23632030	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133686164	+	BCR	chr22	23632728	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133609600	+	BCR	chr22	23633410	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133614221	+	BCR	chr22	23632569	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133715193	+	BCR	chr22	23632419	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133651594	+	BCR	chr22	23633431	+
intron-intron	ENST00000318560	ENST00000436990	ABL1	chr9	133611321	+	BCR	chr22	23632429	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ABL1-BCR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABL1-BCR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:23632600/:133729451)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABL1 P00519	BCR P11274
FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250\|UniProtKB:P00520, ECO:0000269\|PubMed:10391250, ECO:0000269\|PubMed:11971963, ECO:0000269\|PubMed:12379650, ECO:0000269\|PubMed:12531427, ECO:0000269\|PubMed:12672821, ECO:0000269\|PubMed:15031292, ECO:0000269\|PubMed:15556646, ECO:0000269\|PubMed:15657060, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16424036, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:16943190, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:17623672, ECO:0000269\|PubMed:18328268, ECO:0000269\|PubMed:18945674, ECO:0000269\|PubMed:19891780, ECO:0000269\|PubMed:20357770, ECO:0000269\|PubMed:20417104, ECO:0000269\|PubMed:28428613, ECO:0000269\|PubMed:9037071, ECO:0000269\|PubMed:9144171, ECO:0000269\|PubMed:9461559}.	FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250\|UniProtKB:Q6PAJ1, ECO:0000269\|PubMed:1657398, ECO:0000269\|PubMed:17116687, ECO:0000269\|PubMed:1903516, ECO:0000269\|PubMed:23940119, ECO:0000269\|PubMed:7479768}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ABL1-BCR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABL1-BCR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABL1-BCR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABL1-BCR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source