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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANLN-POU6F2 (FusionGDB2 ID:4834)

Fusion Gene Summary for ANLN-POU6F2

check button Fusion gene summary
Fusion gene informationFusion gene name: ANLN-POU6F2
Fusion gene ID: 4834
HgeneTgene
Gene symbol

ANLN

POU6F2

Gene ID

54443

11281

Gene nameanillin actin binding proteinPOU class 6 homeobox 2
SynonymsFSGS8|Scraps|scraRPF-1|WT5|WTSL
Cytomap

7p14.2

7p14.1

Type of geneprotein-codingprotein-coding
DescriptionanillinPOU domain, class 6, transcription factor 2Wilms tumor suppressor locusretina-derived POU-domain factor-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265748, ENST00000396068, 
ENST00000495714, 		ENST00000517348, 
ENST00000464276, ENST00000559001, 
ENST00000403058, ENST00000518318, 
Fusion gene scores* DoF score6 X 8 X 7=3367 X 9 X 9=567
# samples 1012
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/567*10)=-2.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANLN [Title/Abstract] AND POU6F2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANLN(36483471)-POU6F2(39125460), # samples:3
Anticipated loss of major functional domain due to fusion event.ANLN-POU6F2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ANLN-POU6F2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
ANLN-POU6F2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANLN

GO:0000281

mitotic cytokinesis

10931866


check buttonFusion gene breakpoints across ANLN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POU6F2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A3IV-01AANLNchr7

36483471

-POU6F2chr7

39125460

+
ChimerDB4BLCATCGA-DK-A3IV-01AANLNchr7

36483471

+POU6F2chr7

39125460

+
ChimerDB4GBMTCGA-26-A7UX-01BANLNchr7

36463552

+POU6F2chr7

39500146

+


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Fusion Gene ORF analysis for ANLN-POU6F2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000265748ENST00000517348ANLNchr7

36483471

+POU6F2chr7

39125460

+
5CDS-3UTRENST00000396068ENST00000517348ANLNchr7

36483471

+POU6F2chr7

39125460

+
5CDS-5UTRENST00000265748ENST00000464276ANLNchr7

36483471

+POU6F2chr7

39125460

+
5CDS-5UTRENST00000265748ENST00000559001ANLNchr7

36483471

+POU6F2chr7

39125460

+
5CDS-5UTRENST00000396068ENST00000464276ANLNchr7

36483471

+POU6F2chr7

39125460

+
5CDS-5UTRENST00000396068ENST00000559001ANLNchr7

36483471

+POU6F2chr7

39125460

+
5CDS-intronENST00000265748ENST00000464276ANLNchr7

36463552

+POU6F2chr7

39500146

+
5CDS-intronENST00000265748ENST00000517348ANLNchr7

36463552

+POU6F2chr7

39500146

+
5CDS-intronENST00000265748ENST00000559001ANLNchr7

36463552

+POU6F2chr7

39500146

+
5CDS-intronENST00000396068ENST00000464276ANLNchr7

36463552

+POU6F2chr7

39500146

+
5CDS-intronENST00000396068ENST00000517348ANLNchr7

36463552

+POU6F2chr7

39500146

+
5CDS-intronENST00000396068ENST00000559001ANLNchr7

36463552

+POU6F2chr7

39500146

+
Frame-shiftENST00000265748ENST00000403058ANLNchr7

36463552

+POU6F2chr7

39500146

+
Frame-shiftENST00000265748ENST00000518318ANLNchr7

36463552

+POU6F2chr7

39500146

+
Frame-shiftENST00000396068ENST00000403058ANLNchr7

36463552

+POU6F2chr7

39500146

+
Frame-shiftENST00000396068ENST00000518318ANLNchr7

36463552

+POU6F2chr7

39500146

+
In-frameENST00000265748ENST00000403058ANLNchr7

36483471

+POU6F2chr7

39125460

+
In-frameENST00000265748ENST00000518318ANLNchr7

36483471

+POU6F2chr7

39125460

+
In-frameENST00000396068ENST00000403058ANLNchr7

36483471

+POU6F2chr7

39125460

+
In-frameENST00000396068ENST00000518318ANLNchr7

36483471

+POU6F2chr7

39125460

+
intron-3CDSENST00000495714ENST00000403058ANLNchr7

36483471

+POU6F2chr7

39125460

+
intron-3CDSENST00000495714ENST00000403058ANLNchr7

36463552

+POU6F2chr7

39500146

+
intron-3CDSENST00000495714ENST00000518318ANLNchr7

36483471

+POU6F2chr7

39125460

+
intron-3CDSENST00000495714ENST00000518318ANLNchr7

36463552

+POU6F2chr7

39500146

+
intron-3UTRENST00000495714ENST00000517348ANLNchr7

36483471

+POU6F2chr7

39125460

+
intron-5UTRENST00000495714ENST00000464276ANLNchr7

36483471

+POU6F2chr7

39125460

+
intron-5UTRENST00000495714ENST00000559001ANLNchr7

36483471

+POU6F2chr7

39125460

+
intron-intronENST00000495714ENST00000464276ANLNchr7

36463552

+POU6F2chr7

39500146

+
intron-intronENST00000495714ENST00000517348ANLNchr7

36463552

+POU6F2chr7

39500146

+
intron-intronENST00000495714ENST00000559001ANLNchr7

36463552

+POU6F2chr7

39500146

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265748ANLNchr736483471+ENST00000403058POU6F2chr739125460+5462329922153561711
ENST00000265748ANLNchr736483471+ENST00000518318POU6F2chr739125460+9164329922152481675
ENST00000396068ANLNchr736483471+ENST00000403058POU6F2chr739125460+5336317320652301674
ENST00000396068ANLNchr736483471+ENST00000518318POU6F2chr739125460+9038317320651221638

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265748ENST00000403058ANLNchr736483471+POU6F2chr739125460+0.0055673180.9944326
ENST00000265748ENST00000518318ANLNchr736483471+POU6F2chr739125460+0.0003878030.9996123
ENST00000396068ENST00000403058ANLNchr736483471+POU6F2chr739125460+0.0057498730.9942502
ENST00000396068ENST00000518318ANLNchr736483471+POU6F2chr739125460+0.0003788390.99962115

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Fusion Genomic Features for ANLN-POU6F2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANLNchr736463552+POU6F2chr739500145+4.53E-060.99999547
ANLNchr736483471+POU6F2chr739125460+2.06E-060.999998
ANLNchr736463552+POU6F2chr739500145+4.53E-060.99999547
ANLNchr736483471+POU6F2chr739125460+2.06E-060.999998

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANLN-POU6F2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:36483471/chr7:39125460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANLNchr7:36483471chr7:39125460ENST00000265748+2224569_60410261125.0Coiled coilOntology_term=ECO:0000255
HgeneANLNchr7:36483471chr7:39125460ENST00000396068+2123569_6049891088.0Coiled coilOntology_term=ECO:0000255
HgeneANLNchr7:36483471chr7:39125460ENST00000265748+22241_23010261125.0RegionNote=Nuclear localization
HgeneANLNchr7:36483471chr7:39125460ENST00000265748+22241_4510261125.0RegionNote=Required for ubiquitination
HgeneANLNchr7:36483471chr7:39125460ENST00000396068+21231_2309891088.0RegionNote=Nuclear localization
HgeneANLNchr7:36483471chr7:39125460ENST00000396068+21231_459891088.0RegionNote=Required for ubiquitination
TgenePOU6F2chr7:36483471chr7:39125460ENST00000403058111167_4466692.0Compositional biasNote=Gln-rich
TgenePOU6F2chr7:36483471chr7:39125460ENST00000403058111197_2936692.0Compositional biasNote=Pro-rich
TgenePOU6F2chr7:36483471chr7:39125460ENST00000403058111435_4616692.0Compositional biasNote=Ser-rich
TgenePOU6F2chr7:36483471chr7:39125460ENST00000518318010167_4466656.0Compositional biasNote=Gln-rich
TgenePOU6F2chr7:36483471chr7:39125460ENST00000518318010197_2936656.0Compositional biasNote=Pro-rich
TgenePOU6F2chr7:36483471chr7:39125460ENST00000518318010435_4616656.0Compositional biasNote=Ser-rich
TgenePOU6F2chr7:36483471chr7:39125460ENST00000403058111607_6666692.0DNA bindingHomeobox
TgenePOU6F2chr7:36483471chr7:39125460ENST00000518318010607_6666656.0DNA bindingHomeobox
TgenePOU6F2chr7:36483471chr7:39125460ENST00000403058111476_5866692.0DomainPOU-specific
TgenePOU6F2chr7:36483471chr7:39125460ENST00000518318010476_5866656.0DomainPOU-specific

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANLNchr7:36483471chr7:39125460ENST00000265748+2224983_110710261125.0DomainPH
HgeneANLNchr7:36483471chr7:39125460ENST00000396068+2123983_11079891088.0DomainPH
HgeneANLNchr7:36483471chr7:39125460ENST00000265748+2224730_112410261125.0RegionNote=Localization to the cleavage furrow
HgeneANLNchr7:36483471chr7:39125460ENST00000396068+2123730_11249891088.0RegionNote=Localization to the cleavage furrow


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Fusion Gene Sequence for ANLN-POU6F2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4834_4834_1_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000265748_POU6F2_chr7_39125460_ENST00000403058_length(transcript)=5462nt_BP=3299nt
AGCGCGCATGCTCGCGGCTCGGCGCTGAAATTCAAATTTGAACGGCTGCAGAGGCCGAGTCCGTCACTGGAAGCCGAGAGGAGAGGACAG
CTGGTTGTGGGAGAGTTCCCCCGCCTCAGACTCCTGGTTTTTTCCAGGAGACACACTGAGCTGAGACTCACTTTTCTCTTCCTGAATTTG
AACCACCGTTTCCATCGTCTCGTAGTCCGACGCCTGGGGCGATGGATCCGTTTACGGAGAAACTGCTGGAGCGAACCCGTGCCAGGCGAG
AGAATCTTCAGAGAAAAATGGCTGAGAGGCCCACAGCAGCTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGAAG
CAAGTAACCAGCAGCCCCTCTCTGGTGGTGAAGAGAAATCTTGTACAAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAG
TAGAAGTTTCTAACTTGGAAAATAAACAACCAGTTGAGTCGACATCTGCAAAATCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGC
CACAAGCAGCAGATACCATCAGTGATTCTGTTGCTGTCCCGGCATCACTGCTGGGCATGAGGAGAGGGCTGAACTCAAGATTGGAAGCAA
CTGCAGCCTCCTCAGTTAAAACACGTATGCAAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGATGATATGACAGATGACATTCCTG
AAAGCTCACTCTTCTCACCAATGCCATCAGAGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCTCGGCAACTCCAGTTG
GCAGAAGGGGCCGTCTGGCCAATCTTGCTGCAACTATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAACAGTGTAC
AAGAACAGCCTGGTACCGCTTGTTTATCCAAATTTTCCTCTGCAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAG
CTACATTCTGTTCCCAAAGGGATGGCGATGCCTCTTTGAATAAAGCCCTATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAA
TTTCCAGCTCTGTGAAAGCTACTTCTCCAGTGAAATCTACTACATCTATCACTGATGCTAAAAGTTGTGAGGGACAAAATCCTGAGCTAC
TTCCAAAAACTCCTATTAGTCCTCTGAAAACGGGGGTATCGAAACCAATTGTGAAGTCAACTTTATCCCAGACAGTTCCATCCAAGGGAG
AATTAAGTAGAGAAATTTGTCTGCAATCTCAATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTAAGCCTTTCCTGGAACGCT
TTGGAGAGCGTTGTCAAGAACATAGCAAAGAAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAATACAAAGGCCA
TCCAAGAAAGATTATTCAAGCAAGACACATCTTCATCTACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTAGCAT
GTCTTCGTGGCCGATTTGACAAGGGCAATATATGGAGTGCAGAAAAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAA
CTCACTGTCAGAGCACTCCCCTCAAAAAACACCAAGGTGTTTCAAAAACTCAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGA
TACCAGCCAAAAATTCTAGTACAGAACCTAAAGGTTTCACTGAATGCGAAATGACGAAATCTAGCCCTTTGAAAATAACATTGTTTTTAG
AAGAGGACAAATCCTTAAAAGTAACATCAGACCCAAAGGTTGAGCAGAAAATTGAAGTGATACGTGAAATTGAGATGAGTGTGGATGATG
ATGATATCAATAGTTCGAAAGTAATTAATGACCTCTTCAGTGATGTCCTAGAGGAAGGTGAACTAGATATGGAGAAGAGCCAAGAGGAGA
TGGATCAAGCATTAGCAGAAAGCAGCGAAGAACAGGAAGATGCACTGAATATCTCCTCAATGTCTTTACTTGCACCATTGGCACAAACAG
TTGGTGTGGTAAGTCCAGAGAGTTTAGTGTCCACACCTAGACTGGAATTGAAAGACACCAGCAGAAGTGATGAAAGTCCAAAACCAGGAA
AATTCCAAAGAACTCGTGTCCCTCGAGCTGAATCTGGTGATAGCCTTGGTTCTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATA
GATCTCAAAGATTCAAAGAAACAGAACGTCCATCAATAAAGCAGGTGATTGTTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAA
ATAATGCCTTTCCTTGTCAAGTTAATATCAAACAGAAAATGCAGGAACTCAATAACGAAATAAATATGCAACAGACAGTGATCTATCAAG
CTAGCCAGGCTCTTAACTGCTGTGTTGATGAAGAACATGGAAAAGGGTCCCTAGAAGAAGCTGAAGCAGAAAGACTTCTTCTAATTGCAA
CTGGGAAGAGAACACTTTTGATTGATGAATTGAATAAATTGAAGAACGAAGGACCTCAGAGGAAGAATAAGGCTAGTCCCCAAAGTGAAT
TTATGCCATCCAAAGGATCAGTTACTTTGTCAGAAATCCGCTTGCCTCTAAAAGCAGATTTTGTCTGCAGTACGGTTCAGAAACCAGATG
CAGCAAATTACTATTACTTAATTATACTAAAAGCAGGAGCTGAAAATATGGTAGCCACACCATTAGCAAGTACTTCAAACTCTCTTAACG
GTGATGCTCTGACATTCACTACTACATTTACTCTGCAAGATGTATCCAATGACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAA
AGAAAGATCCCTCAGGCCTTGATAAGAAGAAAAAAACATCCAAGTCCAAGGCTATTACTCCAAAGCGACTCCTCACATCTATAACCACAA
AAAGCAACATTCATTCTTCAGTCATGGCCAGTCCAGGAGGTCTTAGTGCTGTGCGAACCAGCAACTTCGCCCTTGTTGGATCTTACACAT
TATCATTGTCTTCAGTAGGAAATACTAAGTTTGTTCTGGACAAGGTCCCCTTTTTATCTTCTTTGGAAGGTCATATTTATTTAAAAATAA
AATGTCAAGTGAATTCCAGTGTTGAAGAAAGAGGTTTTCTAACCATATTTGAAGATGTTAGTGGTTTTGGTGCCTGGCATCGAAGATGGT
GTGTTCTTTCTGGAAACTGTATATCTTATTGGACTTATCCAGATGATGAGAAACGCAAGGATCCAATGATAGCTGGACAAGTCAGTAAGC
CCTTGCTGTCAGTGCGGAGTGAAATGAATGCGGAGTTGAGAGGTGAGGACAAGGCTGCTACTTCAGACAGCGAGCTGAATGAGCCCCTGC
TTGCGCCTGTGGAATCAAATGACAGCGAGGACACTCCCAGCAAGCTCTTCGGGGCTAGAGGAAACCCAGCATTATCAGACCCAGGCACTC
CTGACCAACACCAGGCCAGTCAGACCCACCCCCCATTTCCAGTTGGGCCACAGCCACTTCTGACGGCACAGCAGTTAGCTTCTGCTGTGG
CCGGCGTGATGCCGGGAGGCCCCCCAGCCCTCAACCAGCCAATCCTCATTCCCTTCAACATGGCGGGACAGCTAGGAGGCCAGCAAGGAC
TGGTTCTCACACTGCCAACAGCGAATCTCACCAACATCCAAGGGCTGGTGGCAGCAGCTGCAGCCGGAGGCATTATGACTCTGCCACTGC
AAAATCTACAAGCTACCTCATCCCTGAACTCCCAGCTCCAGCAGCTCCAGCTCCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC
CTCCCCCGTCAACCAACCAGCACCCGCAACCAGCCCCACAGGCGCCCTCGCAGTCCCAGCAGCAGCCGCTGCAGCCCACCCCACCCCAGC
AGCCACCACCCGCCTCTCAGCAGCCGCCAGCTCCTACATCTCAGCTGCAACAGGCGCCTCAGCCCCAGCAGCACCAACCCCACTCCCACT
CCCAGAACCAGAACCAACCATCTCCAACCCAGCAGAGCTCCAGCCCCCCGCAGAAACCTAGTCAGTCTCCAGGACATGGCCTGCCTTCAC
CGCTCACGCCACCCAATCCTCTACAGCTGGTTAATAATCCACTAGCAAGTCAGGCTGCAGCGGCTGCAGCAGCCATGAGCTCCATAGCAA
GCTCACAGGCCTTTGGCAATGCCCTCTCCAGTCTTCAGGGGGTCACAGGTCAACTAGTTACTAATGCACAAGGACAGATTATCGGGACCA
TTCCACTGATGCCTAATCCAGGGCCATCGAGCCAAGCAGCAAGCGGCACTCAGGGCTTGCAAGTGCAGCCAATCACCCCCCAGCTCCTCA
CAAACGCCCAGGGCCAGATCATCGCCACAGTCATTGGGAACCAGATCCTGCCCGTGATCAACACCCAGGGCATCACGCTGTCACCCATCA
AGCCCGGCCAGCAGCTCCACCAACCCTCCCAGACGTCAGTGGGTCAAGCAGCCTCCCAAGGCAACCTTCTGCACCTGGCTCACAGCCAAG
CATCCATGTCTCAAAGTCCCGTCCGGCAGGCTTCCTCTTCTTCCTCCTCATCCTCCTCTTCTTCAGCTTTGAGCGTGGGCCAGTTAGTCA
GCAATCCTCAAACGGCAGCGGGTGAGGTGGATGGGGTTAATCTGGAGGAGATCCGAGAATTTGCCAAAGCTTTTAAAATCCGGCGCCTGT
CCCTTGGCCTGACCCAGACTCAGGTGGGACAGGCTCTCAGTGCTACAGAGGGCCCCGCGTACAGCCAGTCGGCCATCTGCAGACACACCA
TCCTGAGAAGCCACTTTTTCCTACCACAGGAAGCCCAAGAGAACACTATAGCTAGCAGTCTGACAGCCAAACTGAACCCTGGCCTTTTGT
ATCCTGCCAGGTTTGAAAAGCTGGACATCACCCCTAAAAGTGCCCAGAAGATCAAGCCGGTGCTTGAGCGGTGGATGGCTGAGGCTGAGG
CCCGCCATCGAGCAGGTATGCAGAACCTGACCGAGTTTATCGGGAGTGAACCATCCAAAAAGCGCAAGCGGCGCACCTCCTTCACACCCC
AGGCCCTTGAGATCCTCAATGCCCACTTTGAGAAGAACACACACCCTTCTGGGCAGGAAATGACCGAAATTGCTGAGAAGCTGAACTATG
ACCGAGAAGTAGTTAGAGTTTGGTTCTGCAATAAGAGGCAAGCCCTGAAGAACACAATTAAACGCTTAAAACAGCACGAGCCGGCCACGG
CAGTCCCTTTGGAGCCCTTAACAGACTCTCTGGAAGAAAACTCCTAAAGAGATGCCCACCCATAATCAGAAGCAAAATTCACAGAAACTA

>4834_4834_1_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000265748_POU6F2_chr7_39125460_ENST00000403058_length(amino acids)=1711AA_BP=6
MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVES
TSAKSCSPSPVSPQVQPQAADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKA
ASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLN
KALSSSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKD
KSTTPGGTGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSA
EKGGNSKSKQLETKQETHCQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKGFTECEMTKSSPLKITLFLEEDKSLKVTSDPKV
EQKIEVIREIEMSVDDDDINSSKVINDLFSDVLEEGELDMEKSQEEMDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPR
LELKDTSRSDESPKPGKFQRTRVPRAESGDSLGSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKM
QELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIR
LPLKADFVCSTVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTS
KSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFL
TIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPS
KLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLLTAQQLASAVAGVMPGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQ
GLVAAAAAGGIMTLPLQNLQATSSLNSQLQQLQLQLQQQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTS
QLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPSQSPGHGLPSPLTPPNPLQLVNNPLASQAAAAAAAMSSIASSQAFGNALSSLQG
VTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSV
GQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALS
ATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFI
GSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPATAVPLEPLTDSLEEN

--------------------------------------------------------------
>4834_4834_2_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000265748_POU6F2_chr7_39125460_ENST00000518318_length(transcript)=9164nt_BP=3299nt
AGCGCGCATGCTCGCGGCTCGGCGCTGAAATTCAAATTTGAACGGCTGCAGAGGCCGAGTCCGTCACTGGAAGCCGAGAGGAGAGGACAG
CTGGTTGTGGGAGAGTTCCCCCGCCTCAGACTCCTGGTTTTTTCCAGGAGACACACTGAGCTGAGACTCACTTTTCTCTTCCTGAATTTG
AACCACCGTTTCCATCGTCTCGTAGTCCGACGCCTGGGGCGATGGATCCGTTTACGGAGAAACTGCTGGAGCGAACCCGTGCCAGGCGAG
AGAATCTTCAGAGAAAAATGGCTGAGAGGCCCACAGCAGCTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGAAG
CAAGTAACCAGCAGCCCCTCTCTGGTGGTGAAGAGAAATCTTGTACAAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAG
TAGAAGTTTCTAACTTGGAAAATAAACAACCAGTTGAGTCGACATCTGCAAAATCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGC
CACAAGCAGCAGATACCATCAGTGATTCTGTTGCTGTCCCGGCATCACTGCTGGGCATGAGGAGAGGGCTGAACTCAAGATTGGAAGCAA
CTGCAGCCTCCTCAGTTAAAACACGTATGCAAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGATGATATGACAGATGACATTCCTG
AAAGCTCACTCTTCTCACCAATGCCATCAGAGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCTCGGCAACTCCAGTTG
GCAGAAGGGGCCGTCTGGCCAATCTTGCTGCAACTATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAACAGTGTAC
AAGAACAGCCTGGTACCGCTTGTTTATCCAAATTTTCCTCTGCAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAG
CTACATTCTGTTCCCAAAGGGATGGCGATGCCTCTTTGAATAAAGCCCTATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAA
TTTCCAGCTCTGTGAAAGCTACTTCTCCAGTGAAATCTACTACATCTATCACTGATGCTAAAAGTTGTGAGGGACAAAATCCTGAGCTAC
TTCCAAAAACTCCTATTAGTCCTCTGAAAACGGGGGTATCGAAACCAATTGTGAAGTCAACTTTATCCCAGACAGTTCCATCCAAGGGAG
AATTAAGTAGAGAAATTTGTCTGCAATCTCAATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTAAGCCTTTCCTGGAACGCT
TTGGAGAGCGTTGTCAAGAACATAGCAAAGAAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAATACAAAGGCCA
TCCAAGAAAGATTATTCAAGCAAGACACATCTTCATCTACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTAGCAT
GTCTTCGTGGCCGATTTGACAAGGGCAATATATGGAGTGCAGAAAAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAA
CTCACTGTCAGAGCACTCCCCTCAAAAAACACCAAGGTGTTTCAAAAACTCAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGA
TACCAGCCAAAAATTCTAGTACAGAACCTAAAGGTTTCACTGAATGCGAAATGACGAAATCTAGCCCTTTGAAAATAACATTGTTTTTAG
AAGAGGACAAATCCTTAAAAGTAACATCAGACCCAAAGGTTGAGCAGAAAATTGAAGTGATACGTGAAATTGAGATGAGTGTGGATGATG
ATGATATCAATAGTTCGAAAGTAATTAATGACCTCTTCAGTGATGTCCTAGAGGAAGGTGAACTAGATATGGAGAAGAGCCAAGAGGAGA
TGGATCAAGCATTAGCAGAAAGCAGCGAAGAACAGGAAGATGCACTGAATATCTCCTCAATGTCTTTACTTGCACCATTGGCACAAACAG
TTGGTGTGGTAAGTCCAGAGAGTTTAGTGTCCACACCTAGACTGGAATTGAAAGACACCAGCAGAAGTGATGAAAGTCCAAAACCAGGAA
AATTCCAAAGAACTCGTGTCCCTCGAGCTGAATCTGGTGATAGCCTTGGTTCTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATA
GATCTCAAAGATTCAAAGAAACAGAACGTCCATCAATAAAGCAGGTGATTGTTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAA
ATAATGCCTTTCCTTGTCAAGTTAATATCAAACAGAAAATGCAGGAACTCAATAACGAAATAAATATGCAACAGACAGTGATCTATCAAG
CTAGCCAGGCTCTTAACTGCTGTGTTGATGAAGAACATGGAAAAGGGTCCCTAGAAGAAGCTGAAGCAGAAAGACTTCTTCTAATTGCAA
CTGGGAAGAGAACACTTTTGATTGATGAATTGAATAAATTGAAGAACGAAGGACCTCAGAGGAAGAATAAGGCTAGTCCCCAAAGTGAAT
TTATGCCATCCAAAGGATCAGTTACTTTGTCAGAAATCCGCTTGCCTCTAAAAGCAGATTTTGTCTGCAGTACGGTTCAGAAACCAGATG
CAGCAAATTACTATTACTTAATTATACTAAAAGCAGGAGCTGAAAATATGGTAGCCACACCATTAGCAAGTACTTCAAACTCTCTTAACG
GTGATGCTCTGACATTCACTACTACATTTACTCTGCAAGATGTATCCAATGACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAA
AGAAAGATCCCTCAGGCCTTGATAAGAAGAAAAAAACATCCAAGTCCAAGGCTATTACTCCAAAGCGACTCCTCACATCTATAACCACAA
AAAGCAACATTCATTCTTCAGTCATGGCCAGTCCAGGAGGTCTTAGTGCTGTGCGAACCAGCAACTTCGCCCTTGTTGGATCTTACACAT
TATCATTGTCTTCAGTAGGAAATACTAAGTTTGTTCTGGACAAGGTCCCCTTTTTATCTTCTTTGGAAGGTCATATTTATTTAAAAATAA
AATGTCAAGTGAATTCCAGTGTTGAAGAAAGAGGTTTTCTAACCATATTTGAAGATGTTAGTGGTTTTGGTGCCTGGCATCGAAGATGGT
GTGTTCTTTCTGGAAACTGTATATCTTATTGGACTTATCCAGATGATGAGAAACGCAAGGATCCAATGATAGCTGGACAAGTCAGTAAGC
CCTTGCTGTCAGTGCGGAGTGAAATGAATGCGGAGTTGAGAGGTGAGGACAAGGCTGCTACTTCAGACAGCGAGCTGAATGAGCCCCTGC
TTGCGCCTGTGGAATCAAATGACAGCGAGGACACTCCCAGCAAGCTCTTCGGGGCTAGAGGAAACCCAGCATTATCAGACCCAGGCACTC
CTGACCAACACCAGGCCAGTCAGACCCACCCCCCATTTCCAGTTGGGCCACAGCCACTTCTGACGGCACAGCAGTTAGCTTCTGCTGTGG
CCGGCGTGATGCCGGGAGGCCCCCCAGCCCTCAACCAGCCAATCCTCATTCCCTTCAACATGGCGGGACAGCTAGGAGGCCAGCAAGGAC
TGGTTCTCACACTGCCAACAGCGAATCTCACCAACATCCAAGGGCTGGTGGCAGCAGCTGCAGCCGGAGGCATTATGACTCTGCCACTGC
AAAATCTACAAGCTACCTCATCCCTGAACTCCCAGCTCCAGCAGCTCCAGCTCCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC
CTCCCCCGTCAACCAACCAGCACCCGCAACCAGCCCCACAGGCGCCCTCGCAGTCCCAGCAGCAGCCGCTGCAGCCCACCCCACCCCAGC
AGCCACCACCCGCCTCTCAGCAGCCGCCAGCTCCTACATCTCAGCTGCAACAGGCGCCTCAGCCCCAGCAGCACCAACCCCACTCCCACT
CCCAGAACCAGAACCAACCATCTCCAACCCAGCAGAGCTCCAGCCCCCCGCAGAAACCTAGTCAGTCTCCAGGACATGGCCTGCCTTCAC
CGCTCACGCCACCCAATCCTCTACAGCTGGTTAATAATCCACTAGCAAGTCAGGCTGCAGCGGCTGCAGCAGCCATGAGCTCCATAGCAA
GCTCACAGGCCTTTGGCAATGCCCTCTCCAGTCTTCAGGGGGTCACAGGTCAACTAGTTACTAATGCACAAGGACAGATTATCGGGACCA
TTCCACTGATGCCTAATCCAGGGCCATCGAGCCAAGCAGCAAGCGGCACTCAGGGCTTGCAAGTGCAGCCAATCACCCCCCAGCTCCTCA
CAAACGCCCAGGGCCAGATCATCGCCACAGTCATTGGGAACCAGATCCTGCCCGTGATCAACACCCAGGGCATCACGCTGTCACCCATCA
AGCCCGGCCAGCAGCTCCACCAACCCTCCCAGACGTCAGTGGGTCAAGCAGCCTCCCAAGGCAACCTTCTGCACCTGGCTCACAGCCAAG
CATCCATGTCTCAAAGTCCCGTCCGGCAGGCTTCCTCTTCTTCCTCCTCATCCTCCTCTTCTTCAGCTTTGAGCGTGGGCCAGTTAGTCA
GCAATCCTCAAACGGCAGCGGGTGAGGTGGATGGGGTTAATCTGGAGGAGATCCGAGAATTTGCCAAAGCTTTTAAAATCCGGCGCCTGT
CCCTTGGCCTGACCCAGACTCAGGTGGGACAGGCTCTCAGTGCTACAGAGGGCCCCGCGTACAGCCAGTCGGCCATCTGCAGGTTTGAAA
AGCTGGACATCACCCCTAAAAGTGCCCAGAAGATCAAGCCGGTGCTTGAGCGGTGGATGGCTGAGGCTGAGGCCCGCCATCGAGCAGGTA
TGCAGAACCTGACCGAGTTTATCGGGAGTGAACCATCCAAAAAGCGCAAGCGGCGCACCTCCTTCACACCCCAGGCCCTTGAGATCCTCA
ATGCCCACTTTGAGAAGAACACACACCCTTCTGGGCAGGAAATGACCGAAATTGCTGAGAAGCTGAACTATGACCGAGAAGTAGTTAGAG
TTTGGTTCTGCAATAAGAGGCAAGCCCTGAAGAACACAATTAAACGCTTAAAACAGCACGAGCCGGCCACGGCAGTCCCTTTGGAGCCCT
TAACAGACTCTCTGGAAGAAAACTCCTAAAGAGATGCCCACCCATAATCAGAAGCAAAATTCACAGAAACTAAACTCCACCCTTGGGACT
CCACAACAACAACAACAACAAAATTTAATTTAATTTAAAAATAGCCCCAGTCGTCATCACCCTTGTAAGTAAATGACTAAGAAAACTACC
AAGTGGACAGAATGGTTTCTACATGTCCGTTGGTTTTCCAAAAAGGAAAGAAGAAAATTTTTAGAAAATTTTTAAACAAGGAATACACCA
CACTGAAGGTGTGTGTGGTAGGATAGTTCCCTTCCCCCACCTGTCTCCCCCAAAGCCAGTTTTTTAATGGACTTAAAGCAAACCAAATAA
CCACGTACTTTTTTCTGTATATTATGAAAATGTGAACACATTTTAAGGAAAAAGAAAAAAAAAAACTAAACCAAAAACCAACAACGAAGG
AACAAAAACTTTGATCTGTTCAAAGCGAATACAAGCCTGCCACCTGGAGGAAGGACTGCACCCCTTCAGGTACTAAGTGCTGATTCACTA
TGAAACCTATTAACCAAAGTCAGAAACATGGCATTGCAACGCGATCGTTCGTCTACGCTTCTCCGCACGTAAAGTTGTGTTACGAATTTT
TACATTTGTACTAACAGAACAATAGGAAGCCTGATTTCTCCCATCTTTCCCATCTACTGTCTCCACCCATGGGGTGGGTACCATTGTTGA
AGCCATTCTGTGAGGCTCACTATTGGGTTTTTTTGTGGGGGTGGTAGGGAGGGTGGTCTTTTTTCTTTGTCTTTCTTTTTGACGGGAGGG
CATCCTGGATCGTGTGCCAAAGCATTTGTTGCTTTTTTCTCACTATGACTTGTGGGTTTGAGAAAAGAAAATGGAGCTCGCATTTCTCTC
TTTTCCTCCATTTCTCCATCTCCCTCGCGCGTGGCTCCTGGGGTCTGCTGGAAGGCCACAGAAGTGGGGAGAAGCAGTGTCTTTTCCACT
CAGATCCTAGTGAAATGCAGGAGAGACTCCAAAATAACTAGGGCTTTGCTCGATGAACTGTCAACACTGGCATAAGCTGTAATTGTGCTC
ACTGTCCACACCAGAGCTTGGGATTTTTCTCAGTCTGTTGGCCACGTACATGGAGAGCTGACCAAAACTAATTTTGTAATATAAACATAA
GCTGCACATTTGGTTCAATACTTACATCTATGTTATGCTTCTGTGCAAAGCAATTTCTCTCAGAAGTCTGATAGCCAAAGAAATGTCTCA
AGATTTCAGTCAAATACACACATGACATGCACACACCCATAAACACACACACAAAGAAACAGGCTAAAAAGAAAGTGATAGCAACTGGAT
CATTAAAGGCCATCGTGTATCCTGTTAATCTCATCTTTTCTGCTACTTCTTTCATTCCAATAGCGATGGCAGACTTTTTTCAGGGGGAAT
AATTACTCTTCGGGATATATAAATGGAGCAGAAAGGTGGCGGGCAAATTTAAACAACTGGAATTGGGGGCCAGGTTCTTCAGGGGAAAGG
AAGTTTGAAGAAGCTTTCACCAAAAGAAAAAAATATAGAAGGGGCTTATCTAACAATCAGAATAGCCTGCAATATGAGAACTAGAGGATT
ATTTCCTTTAAAAAAAATAACTTAAAAGATCTGTGGGCCACAATAACCTAATAAGCAAGGACATGTTGGGATGTGAGGACGGCTGTGCAG
GTGAGCACTTGGCAGCTGCCACTGGTGTTTTCACCCAGGTACAGGCAGACGGTGTTCCATTAAAGGAGCAGGCAAAAGAGAGCTGTCAAT
TTGCTTGCTGTTGAAATGTACATATTTATGCATAATTTATAATCATGCTAATGTATTATCTAGAAGTAAGTTGTGAAAGAAAAAAGAGAA
ACCCAATCTCAAGTTGCCCAACTGATTAGAAATGCCATCTCCTTCCCCTAATACACTCCCTCTCCCTGGGGAGTTTGAGTTTCTTCTGTT
GGCTCCTTTGCTGTTTGTGTAAATGCTACAGTATAATTGTCCCCTCCAATGATTCATGCAGCAATCAAGAGACTACCAGCAAGGAAACTC
TAAAAGGAATCCTGGAAGTGGAACAAGTCACTCGTAAAGGTGTTTCCATTTTACCAGTCAATGCTAACTGGACCACAGCTAACTTGATCT
TCAATGCCAACATCACAGAGCCCCTTTCGCCACCTCAAAAACTGCACAAACATGGACAACCCAGAAACCCAAAACTTTATTGATTAAAAC
AGATTTTGGATTCTCCTAGGACCTGCTCCAAATTCCATCAAGAAAAGCTCCCTGCGAAGAGAAGTTAACAAGATAACATATGATGGATGC
TAAATATTTAAATATATGCCGGCAGCGGTTACATAAGGCCTGCTCAGTTCTGAGATCTATAATTGGGAGGGTCTAACTAGGACAGGGAAA
ATATAAAATAAAAGTAATCTTCCAGAGTGGAACAAAAAAGAAATATATTCATCCGACAGTCGTAACACCATTCATGTGCAGTGATTTTTT
TATAGTTTTATAATTTTGTATTGTTTTATAAATTATTTATAAGGTGTTGTAATGCTTCTTATATTAATTTTTTACAGATAAATTTTTTGC
TACAAGGCATAAAAAGGTGCCTGAACCGATTCTTAGGAATATAAATTATACTGTGTAACTCATAAGTCTTTGGGACCACACCTAATGCTT
AATTTTATGATGACATTTCTCATGTCTACTTGTAAACAACTTCATATGCCAATGGCGTTTAAGTGTCTTTTATGTTTCCATGAACTGAAG
GTTAAGGTTGCCACCCACAAAAAATAAAAGCCACTTTGGGCATATGTGATTGTATTTCAAGCTTCAGTATTTTTCTCACATAATTTTTAA
TTATTGTTATCTGCATTTTCATTACTTCATGAAAAAATGACAGTGGATATTACATTTTACACTTGTTTATAGATTTTCTTTCTTTTTCAA
CCAAGAAAATATTTTGAACAATTGAAACTTTTAATTGCATTTGCAAGGTTTTGGCTTCTTTATGTTGTCATCACACAGATGCACACACAC
ATACACATACAACACAAAAGAGAGAACAAAAAAGCAAAAGGAGCTAGGAAAAAAACAAAACAAAACAAGTAGAGGTGTATCAAAGAACTC
AAGCTATAACCAAAAAGAAATCGTAAAATGCCTTTGCTCGTTTCTCTACGCTGGACCAAAGCTCAATATTTGTAGGTATATGCACATTGT
ATAGATATGGCTAAATGTTGCTGACAATCTCGCAATACTAAACTGTTCCTATTTTAAGAAAAAAAAAAGAAATACAAACTGTTCATCAAT
GTTTTACCTCAGCACTCTACTTGTACCCAGTTAATGACCAAGCTTAAAAAAAAATTGAGATAAAGGAAATTGATTTTCATTTCAATGTTT
GACTGTAAAATCTGTTTGGATAACATTTTGTAATGAGCTTTTTGTCATGTGATTTGCTTGTCTTCAACTTGAAATTATGTGAGGCACATT
TGTTTATTTGTTGTTAAGAAAGTGATTTTTTTTTTTTTTTGTCCTATGTGCTGTGATCTAGACTGGTCACCGGGGTCACTTATGAGGCAC
CACAAAGAGATCTGCTTCTCCGTGCCCGGAGCAGGCAGCAGGAGGGAGGGCAGGAAACAGGACTGGGTTGCTTTGGAAAAATCATCATGA
CAAGAAGTTGACATGATAGACTTGTGACCAAGAAGCCAAACTGAATATTTAAAAGCTCCTTACTTGCTCTGACATTGAAACCAAAGCTGA
TTTTATCTGCACAGGTTGCTTAATATTTAAAAAAAAAAAAAACTGTACTTAATCTAGAGCAATATCTGTATGGTCAGTAAAGCTGCACTT

>4834_4834_2_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000265748_POU6F2_chr7_39125460_ENST00000518318_length(amino acids)=1675AA_BP=6
MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVES
TSAKSCSPSPVSPQVQPQAADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKA
ASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLN
KALSSSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKD
KSTTPGGTGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSA
EKGGNSKSKQLETKQETHCQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKGFTECEMTKSSPLKITLFLEEDKSLKVTSDPKV
EQKIEVIREIEMSVDDDDINSSKVINDLFSDVLEEGELDMEKSQEEMDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPR
LELKDTSRSDESPKPGKFQRTRVPRAESGDSLGSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKM
QELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIR
LPLKADFVCSTVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTS
KSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFL
TIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPS
KLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLLTAQQLASAVAGVMPGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQ
GLVAAAAAGGIMTLPLQNLQATSSLNSQLQQLQLQLQQQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTS
QLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPSQSPGHGLPSPLTPPNPLQLVNNPLASQAAAAAAAMSSIASSQAFGNALSSLQG
VTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSV
GQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALS
ATEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQE

--------------------------------------------------------------
>4834_4834_3_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000396068_POU6F2_chr7_39125460_ENST00000403058_length(transcript)=5336nt_BP=3173nt
GGCTCGGCGCTGAAATTCAAATTTGAACGGCTGCAGAGGCCGAGTCCGTCACTGGAAGCCGAGAGGAGAGGACAGCTGGTTGTGGGAGAG
TTCCCCCGCCTCAGACTCCTGGTTTTTTCCAGGAGACACACTGAGCTGAGACTCACTTTTCTCTTCCTGAATTTGAACCACCGTTTCCAT
CGTCTCGTAGTCCGACGCCTGGGGCGATGGATCCGTTTACGGAGAAACTGCTGGAGCGAACCCGTGCCAGGCGAGAGAATCTTCAGAGAA
AAATGGCTGAGAGGCCCACAGCAGCTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGAAGCAAGTAACCAGCAGC
CCCTCTCTGGTGGTGAAGAGAAATCTTGTACAAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAGTAGAAGTTTCTAACT
TGGAAAATAAACAACCAGTTGAGTCGACATCTGCAAAATCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGCCACAAGCAGCAGATA
CCATCAGTGATTCTGTTGCTGTCCCGGCATCACTGCTGGGCATGAGGAGAGGGCTGAACTCAAGATTGGAAGCAACTGCAGCCTCCTCAG
TTAAAACACGTATGCAAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGATGATATGACAGATGACATTCCTGAAAGCTCACTCTTCT
CACCAATGCCATCAGAGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCTCGGCAACTCCAGTTGGCAGAAGGGGCCGTC
TGGCCAATCTTGCTGCAACTATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAACAGTGTACAAGAACAGCCTGGTA
CCGCTTGTTTATCCAAATTTTCCTCTGCAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAGCTACATTCTGTTCCC
AAAGGGATGGCGATGCCTCTTTGAATAAAGCCCTATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAATTTCCAGCTCTGTGA
AAGCTACTTCTCCAGTGAAATCTACTACATCTATCACTGATGCTAAAAGTTGTGAGGGACAAAATCCTGAGCTACTTCCAAAAACTCCTA
TTAGTCCTCTGAAAACGGGGGTATCGAAACCAATTGTGAAGTCAACTTTATCCCAGACAGTTCCATCCAAGGGAGAATTAAGTAGAGAAA
TTTGTCTGCAATCTCAATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTAAGCCTTTCCTGGAACGCTTTGGAGAGCGTTGTC
AAGAACATAGCAAAGAAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAATACAAAGGCCATCCAAGAAAGATTAT
TCAAGCAAGACACATCTTCATCTACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTAGCATGTCTTCGTGGCCGAT
TTGACAAGGGCAATATATGGAGTGCAGAAAAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAACTCACTGTCAGAGCA
CTCCCCTCAAAAAACACCAAGGTGTTTCAAAAACTCAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGATACCAGCCAAAAATT
CTAGTACAGAACCTAAAGAAGTGATACGTGAAATTGAGATGAGTGTGGATGATGATGATATCAATAGTTCGAAAGTAATTAATGACCTCT
TCAGTGATGTCCTAGAGGAAGGTGAACTAGATATGGAGAAGAGCCAAGAGGAGATGGATCAAGCATTAGCAGAAAGCAGCGAAGAACAGG
AAGATGCACTGAATATCTCCTCAATGTCTTTACTTGCACCATTGGCACAAACAGTTGGTGTGGTAAGTCCAGAGAGTTTAGTGTCCACAC
CTAGACTGGAATTGAAAGACACCAGCAGAAGTGATGAAAGTCCAAAACCAGGAAAATTCCAAAGAACTCGTGTCCCTCGAGCTGAATCTG
GTGATAGCCTTGGTTCTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATAGATCTCAAAGATTCAAAGAAACAGAACGTCCATCAA
TAAAGCAGGTGATTGTTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAAATAATGCCTTTCCTTGTCAAGTTAATATCAAACAGA
AAATGCAGGAACTCAATAACGAAATAAATATGCAACAGACAGTGATCTATCAAGCTAGCCAGGCTCTTAACTGCTGTGTTGATGAAGAAC
ATGGAAAAGGGTCCCTAGAAGAAGCTGAAGCAGAAAGACTTCTTCTAATTGCAACTGGGAAGAGAACACTTTTGATTGATGAATTGAATA
AATTGAAGAACGAAGGACCTCAGAGGAAGAATAAGGCTAGTCCCCAAAGTGAATTTATGCCATCCAAAGGATCAGTTACTTTGTCAGAAA
TCCGCTTGCCTCTAAAAGCAGATTTTGTCTGCAGTACGGTTCAGAAACCAGATGCAGCAAATTACTATTACTTAATTATACTAAAAGCAG
GAGCTGAAAATATGGTAGCCACACCATTAGCAAGTACTTCAAACTCTCTTAACGGTGATGCTCTGACATTCACTACTACATTTACTCTGC
AAGATGTATCCAATGACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAAAGAAAGATCCCTCAGGCCTTGATAAGAAGAAAAAAA
CATCCAAGTCCAAGGCTATTACTCCAAAGCGACTCCTCACATCTATAACCACAAAAAGCAACATTCATTCTTCAGTCATGGCCAGTCCAG
GAGGTCTTAGTGCTGTGCGAACCAGCAACTTCGCCCTTGTTGGATCTTACACATTATCATTGTCTTCAGTAGGAAATACTAAGTTTGTTC
TGGACAAGGTCCCCTTTTTATCTTCTTTGGAAGGTCATATTTATTTAAAAATAAAATGTCAAGTGAATTCCAGTGTTGAAGAAAGAGGTT
TTCTAACCATATTTGAAGATGTTAGTGGTTTTGGTGCCTGGCATCGAAGATGGTGTGTTCTTTCTGGAAACTGTATATCTTATTGGACTT
ATCCAGATGATGAGAAACGCAAGGATCCAATGATAGCTGGACAAGTCAGTAAGCCCTTGCTGTCAGTGCGGAGTGAAATGAATGCGGAGT
TGAGAGGTGAGGACAAGGCTGCTACTTCAGACAGCGAGCTGAATGAGCCCCTGCTTGCGCCTGTGGAATCAAATGACAGCGAGGACACTC
CCAGCAAGCTCTTCGGGGCTAGAGGAAACCCAGCATTATCAGACCCAGGCACTCCTGACCAACACCAGGCCAGTCAGACCCACCCCCCAT
TTCCAGTTGGGCCACAGCCACTTCTGACGGCACAGCAGTTAGCTTCTGCTGTGGCCGGCGTGATGCCGGGAGGCCCCCCAGCCCTCAACC
AGCCAATCCTCATTCCCTTCAACATGGCGGGACAGCTAGGAGGCCAGCAAGGACTGGTTCTCACACTGCCAACAGCGAATCTCACCAACA
TCCAAGGGCTGGTGGCAGCAGCTGCAGCCGGAGGCATTATGACTCTGCCACTGCAAAATCTACAAGCTACCTCATCCCTGAACTCCCAGC
TCCAGCAGCTCCAGCTCCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCCTCCCCCGTCAACCAACCAGCACCCGCAACCAGCCC
CACAGGCGCCCTCGCAGTCCCAGCAGCAGCCGCTGCAGCCCACCCCACCCCAGCAGCCACCACCCGCCTCTCAGCAGCCGCCAGCTCCTA
CATCTCAGCTGCAACAGGCGCCTCAGCCCCAGCAGCACCAACCCCACTCCCACTCCCAGAACCAGAACCAACCATCTCCAACCCAGCAGA
GCTCCAGCCCCCCGCAGAAACCTAGTCAGTCTCCAGGACATGGCCTGCCTTCACCGCTCACGCCACCCAATCCTCTACAGCTGGTTAATA
ATCCACTAGCAAGTCAGGCTGCAGCGGCTGCAGCAGCCATGAGCTCCATAGCAAGCTCACAGGCCTTTGGCAATGCCCTCTCCAGTCTTC
AGGGGGTCACAGGTCAACTAGTTACTAATGCACAAGGACAGATTATCGGGACCATTCCACTGATGCCTAATCCAGGGCCATCGAGCCAAG
CAGCAAGCGGCACTCAGGGCTTGCAAGTGCAGCCAATCACCCCCCAGCTCCTCACAAACGCCCAGGGCCAGATCATCGCCACAGTCATTG
GGAACCAGATCCTGCCCGTGATCAACACCCAGGGCATCACGCTGTCACCCATCAAGCCCGGCCAGCAGCTCCACCAACCCTCCCAGACGT
CAGTGGGTCAAGCAGCCTCCCAAGGCAACCTTCTGCACCTGGCTCACAGCCAAGCATCCATGTCTCAAAGTCCCGTCCGGCAGGCTTCCT
CTTCTTCCTCCTCATCCTCCTCTTCTTCAGCTTTGAGCGTGGGCCAGTTAGTCAGCAATCCTCAAACGGCAGCGGGTGAGGTGGATGGGG
TTAATCTGGAGGAGATCCGAGAATTTGCCAAAGCTTTTAAAATCCGGCGCCTGTCCCTTGGCCTGACCCAGACTCAGGTGGGACAGGCTC
TCAGTGCTACAGAGGGCCCCGCGTACAGCCAGTCGGCCATCTGCAGACACACCATCCTGAGAAGCCACTTTTTCCTACCACAGGAAGCCC
AAGAGAACACTATAGCTAGCAGTCTGACAGCCAAACTGAACCCTGGCCTTTTGTATCCTGCCAGGTTTGAAAAGCTGGACATCACCCCTA
AAAGTGCCCAGAAGATCAAGCCGGTGCTTGAGCGGTGGATGGCTGAGGCTGAGGCCCGCCATCGAGCAGGTATGCAGAACCTGACCGAGT
TTATCGGGAGTGAACCATCCAAAAAGCGCAAGCGGCGCACCTCCTTCACACCCCAGGCCCTTGAGATCCTCAATGCCCACTTTGAGAAGA
ACACACACCCTTCTGGGCAGGAAATGACCGAAATTGCTGAGAAGCTGAACTATGACCGAGAAGTAGTTAGAGTTTGGTTCTGCAATAAGA
GGCAAGCCCTGAAGAACACAATTAAACGCTTAAAACAGCACGAGCCGGCCACGGCAGTCCCTTTGGAGCCCTTAACAGACTCTCTGGAAG
AAAACTCCTAAAGAGATGCCCACCCATAATCAGAAGCAAAATTCACAGAAACTAAACTCCACCCTTGGGACTCCACAACAACAACAACAA

>4834_4834_3_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000396068_POU6F2_chr7_39125460_ENST00000403058_length(amino acids)=1674AA_BP=6
MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVES
TSAKSCSPSPVSPQVQPQAADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKA
ASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLN
KALSSSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKD
KSTTPGGTGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSA
EKGGNSKSKQLETKQETHCQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKEVIREIEMSVDDDDINSSKVINDLFSDVLEEGE
LDMEKSQEEMDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPRLELKDTSRSDESPKPGKFQRTRVPRAESGDSLGSEDR
DLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKMQELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEA
EAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCSTVQKPDAANYYYLIILKAGAENMVATP
LASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTSKSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTS
NFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKD
PMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPSKLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLL
TAQQLASAVAGVMPGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQQLQLQLQ
QQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTSQLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPS
QSPGHGLPSPLTPPNPLQLVNNPLASQAAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQ
VQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSVGQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSS
SALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSL
TAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEM

--------------------------------------------------------------
>4834_4834_4_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000396068_POU6F2_chr7_39125460_ENST00000518318_length(transcript)=9038nt_BP=3173nt
GGCTCGGCGCTGAAATTCAAATTTGAACGGCTGCAGAGGCCGAGTCCGTCACTGGAAGCCGAGAGGAGAGGACAGCTGGTTGTGGGAGAG
TTCCCCCGCCTCAGACTCCTGGTTTTTTCCAGGAGACACACTGAGCTGAGACTCACTTTTCTCTTCCTGAATTTGAACCACCGTTTCCAT
CGTCTCGTAGTCCGACGCCTGGGGCGATGGATCCGTTTACGGAGAAACTGCTGGAGCGAACCCGTGCCAGGCGAGAGAATCTTCAGAGAA
AAATGGCTGAGAGGCCCACAGCAGCTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGAAGCAAGTAACCAGCAGC
CCCTCTCTGGTGGTGAAGAGAAATCTTGTACAAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAGTAGAAGTTTCTAACT
TGGAAAATAAACAACCAGTTGAGTCGACATCTGCAAAATCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGCCACAAGCAGCAGATA
CCATCAGTGATTCTGTTGCTGTCCCGGCATCACTGCTGGGCATGAGGAGAGGGCTGAACTCAAGATTGGAAGCAACTGCAGCCTCCTCAG
TTAAAACACGTATGCAAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGATGATATGACAGATGACATTCCTGAAAGCTCACTCTTCT
CACCAATGCCATCAGAGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCTCGGCAACTCCAGTTGGCAGAAGGGGCCGTC
TGGCCAATCTTGCTGCAACTATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAACAGTGTACAAGAACAGCCTGGTA
CCGCTTGTTTATCCAAATTTTCCTCTGCAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAGCTACATTCTGTTCCC
AAAGGGATGGCGATGCCTCTTTGAATAAAGCCCTATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAATTTCCAGCTCTGTGA
AAGCTACTTCTCCAGTGAAATCTACTACATCTATCACTGATGCTAAAAGTTGTGAGGGACAAAATCCTGAGCTACTTCCAAAAACTCCTA
TTAGTCCTCTGAAAACGGGGGTATCGAAACCAATTGTGAAGTCAACTTTATCCCAGACAGTTCCATCCAAGGGAGAATTAAGTAGAGAAA
TTTGTCTGCAATCTCAATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTAAGCCTTTCCTGGAACGCTTTGGAGAGCGTTGTC
AAGAACATAGCAAAGAAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAATACAAAGGCCATCCAAGAAAGATTAT
TCAAGCAAGACACATCTTCATCTACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTAGCATGTCTTCGTGGCCGAT
TTGACAAGGGCAATATATGGAGTGCAGAAAAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAACTCACTGTCAGAGCA
CTCCCCTCAAAAAACACCAAGGTGTTTCAAAAACTCAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGATACCAGCCAAAAATT
CTAGTACAGAACCTAAAGAAGTGATACGTGAAATTGAGATGAGTGTGGATGATGATGATATCAATAGTTCGAAAGTAATTAATGACCTCT
TCAGTGATGTCCTAGAGGAAGGTGAACTAGATATGGAGAAGAGCCAAGAGGAGATGGATCAAGCATTAGCAGAAAGCAGCGAAGAACAGG
AAGATGCACTGAATATCTCCTCAATGTCTTTACTTGCACCATTGGCACAAACAGTTGGTGTGGTAAGTCCAGAGAGTTTAGTGTCCACAC
CTAGACTGGAATTGAAAGACACCAGCAGAAGTGATGAAAGTCCAAAACCAGGAAAATTCCAAAGAACTCGTGTCCCTCGAGCTGAATCTG
GTGATAGCCTTGGTTCTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATAGATCTCAAAGATTCAAAGAAACAGAACGTCCATCAA
TAAAGCAGGTGATTGTTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAAATAATGCCTTTCCTTGTCAAGTTAATATCAAACAGA
AAATGCAGGAACTCAATAACGAAATAAATATGCAACAGACAGTGATCTATCAAGCTAGCCAGGCTCTTAACTGCTGTGTTGATGAAGAAC
ATGGAAAAGGGTCCCTAGAAGAAGCTGAAGCAGAAAGACTTCTTCTAATTGCAACTGGGAAGAGAACACTTTTGATTGATGAATTGAATA
AATTGAAGAACGAAGGACCTCAGAGGAAGAATAAGGCTAGTCCCCAAAGTGAATTTATGCCATCCAAAGGATCAGTTACTTTGTCAGAAA
TCCGCTTGCCTCTAAAAGCAGATTTTGTCTGCAGTACGGTTCAGAAACCAGATGCAGCAAATTACTATTACTTAATTATACTAAAAGCAG
GAGCTGAAAATATGGTAGCCACACCATTAGCAAGTACTTCAAACTCTCTTAACGGTGATGCTCTGACATTCACTACTACATTTACTCTGC
AAGATGTATCCAATGACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAAAGAAAGATCCCTCAGGCCTTGATAAGAAGAAAAAAA
CATCCAAGTCCAAGGCTATTACTCCAAAGCGACTCCTCACATCTATAACCACAAAAAGCAACATTCATTCTTCAGTCATGGCCAGTCCAG
GAGGTCTTAGTGCTGTGCGAACCAGCAACTTCGCCCTTGTTGGATCTTACACATTATCATTGTCTTCAGTAGGAAATACTAAGTTTGTTC
TGGACAAGGTCCCCTTTTTATCTTCTTTGGAAGGTCATATTTATTTAAAAATAAAATGTCAAGTGAATTCCAGTGTTGAAGAAAGAGGTT
TTCTAACCATATTTGAAGATGTTAGTGGTTTTGGTGCCTGGCATCGAAGATGGTGTGTTCTTTCTGGAAACTGTATATCTTATTGGACTT
ATCCAGATGATGAGAAACGCAAGGATCCAATGATAGCTGGACAAGTCAGTAAGCCCTTGCTGTCAGTGCGGAGTGAAATGAATGCGGAGT
TGAGAGGTGAGGACAAGGCTGCTACTTCAGACAGCGAGCTGAATGAGCCCCTGCTTGCGCCTGTGGAATCAAATGACAGCGAGGACACTC
CCAGCAAGCTCTTCGGGGCTAGAGGAAACCCAGCATTATCAGACCCAGGCACTCCTGACCAACACCAGGCCAGTCAGACCCACCCCCCAT
TTCCAGTTGGGCCACAGCCACTTCTGACGGCACAGCAGTTAGCTTCTGCTGTGGCCGGCGTGATGCCGGGAGGCCCCCCAGCCCTCAACC
AGCCAATCCTCATTCCCTTCAACATGGCGGGACAGCTAGGAGGCCAGCAAGGACTGGTTCTCACACTGCCAACAGCGAATCTCACCAACA
TCCAAGGGCTGGTGGCAGCAGCTGCAGCCGGAGGCATTATGACTCTGCCACTGCAAAATCTACAAGCTACCTCATCCCTGAACTCCCAGC
TCCAGCAGCTCCAGCTCCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCCTCCCCCGTCAACCAACCAGCACCCGCAACCAGCCC
CACAGGCGCCCTCGCAGTCCCAGCAGCAGCCGCTGCAGCCCACCCCACCCCAGCAGCCACCACCCGCCTCTCAGCAGCCGCCAGCTCCTA
CATCTCAGCTGCAACAGGCGCCTCAGCCCCAGCAGCACCAACCCCACTCCCACTCCCAGAACCAGAACCAACCATCTCCAACCCAGCAGA
GCTCCAGCCCCCCGCAGAAACCTAGTCAGTCTCCAGGACATGGCCTGCCTTCACCGCTCACGCCACCCAATCCTCTACAGCTGGTTAATA
ATCCACTAGCAAGTCAGGCTGCAGCGGCTGCAGCAGCCATGAGCTCCATAGCAAGCTCACAGGCCTTTGGCAATGCCCTCTCCAGTCTTC
AGGGGGTCACAGGTCAACTAGTTACTAATGCACAAGGACAGATTATCGGGACCATTCCACTGATGCCTAATCCAGGGCCATCGAGCCAAG
CAGCAAGCGGCACTCAGGGCTTGCAAGTGCAGCCAATCACCCCCCAGCTCCTCACAAACGCCCAGGGCCAGATCATCGCCACAGTCATTG
GGAACCAGATCCTGCCCGTGATCAACACCCAGGGCATCACGCTGTCACCCATCAAGCCCGGCCAGCAGCTCCACCAACCCTCCCAGACGT
CAGTGGGTCAAGCAGCCTCCCAAGGCAACCTTCTGCACCTGGCTCACAGCCAAGCATCCATGTCTCAAAGTCCCGTCCGGCAGGCTTCCT
CTTCTTCCTCCTCATCCTCCTCTTCTTCAGCTTTGAGCGTGGGCCAGTTAGTCAGCAATCCTCAAACGGCAGCGGGTGAGGTGGATGGGG
TTAATCTGGAGGAGATCCGAGAATTTGCCAAAGCTTTTAAAATCCGGCGCCTGTCCCTTGGCCTGACCCAGACTCAGGTGGGACAGGCTC
TCAGTGCTACAGAGGGCCCCGCGTACAGCCAGTCGGCCATCTGCAGGTTTGAAAAGCTGGACATCACCCCTAAAAGTGCCCAGAAGATCA
AGCCGGTGCTTGAGCGGTGGATGGCTGAGGCTGAGGCCCGCCATCGAGCAGGTATGCAGAACCTGACCGAGTTTATCGGGAGTGAACCAT
CCAAAAAGCGCAAGCGGCGCACCTCCTTCACACCCCAGGCCCTTGAGATCCTCAATGCCCACTTTGAGAAGAACACACACCCTTCTGGGC
AGGAAATGACCGAAATTGCTGAGAAGCTGAACTATGACCGAGAAGTAGTTAGAGTTTGGTTCTGCAATAAGAGGCAAGCCCTGAAGAACA
CAATTAAACGCTTAAAACAGCACGAGCCGGCCACGGCAGTCCCTTTGGAGCCCTTAACAGACTCTCTGGAAGAAAACTCCTAAAGAGATG
CCCACCCATAATCAGAAGCAAAATTCACAGAAACTAAACTCCACCCTTGGGACTCCACAACAACAACAACAACAAAATTTAATTTAATTT
AAAAATAGCCCCAGTCGTCATCACCCTTGTAAGTAAATGACTAAGAAAACTACCAAGTGGACAGAATGGTTTCTACATGTCCGTTGGTTT
TCCAAAAAGGAAAGAAGAAAATTTTTAGAAAATTTTTAAACAAGGAATACACCACACTGAAGGTGTGTGTGGTAGGATAGTTCCCTTCCC
CCACCTGTCTCCCCCAAAGCCAGTTTTTTAATGGACTTAAAGCAAACCAAATAACCACGTACTTTTTTCTGTATATTATGAAAATGTGAA
CACATTTTAAGGAAAAAGAAAAAAAAAAACTAAACCAAAAACCAACAACGAAGGAACAAAAACTTTGATCTGTTCAAAGCGAATACAAGC
CTGCCACCTGGAGGAAGGACTGCACCCCTTCAGGTACTAAGTGCTGATTCACTATGAAACCTATTAACCAAAGTCAGAAACATGGCATTG
CAACGCGATCGTTCGTCTACGCTTCTCCGCACGTAAAGTTGTGTTACGAATTTTTACATTTGTACTAACAGAACAATAGGAAGCCTGATT
TCTCCCATCTTTCCCATCTACTGTCTCCACCCATGGGGTGGGTACCATTGTTGAAGCCATTCTGTGAGGCTCACTATTGGGTTTTTTTGT
GGGGGTGGTAGGGAGGGTGGTCTTTTTTCTTTGTCTTTCTTTTTGACGGGAGGGCATCCTGGATCGTGTGCCAAAGCATTTGTTGCTTTT
TTCTCACTATGACTTGTGGGTTTGAGAAAAGAAAATGGAGCTCGCATTTCTCTCTTTTCCTCCATTTCTCCATCTCCCTCGCGCGTGGCT
CCTGGGGTCTGCTGGAAGGCCACAGAAGTGGGGAGAAGCAGTGTCTTTTCCACTCAGATCCTAGTGAAATGCAGGAGAGACTCCAAAATA
ACTAGGGCTTTGCTCGATGAACTGTCAACACTGGCATAAGCTGTAATTGTGCTCACTGTCCACACCAGAGCTTGGGATTTTTCTCAGTCT
GTTGGCCACGTACATGGAGAGCTGACCAAAACTAATTTTGTAATATAAACATAAGCTGCACATTTGGTTCAATACTTACATCTATGTTAT
GCTTCTGTGCAAAGCAATTTCTCTCAGAAGTCTGATAGCCAAAGAAATGTCTCAAGATTTCAGTCAAATACACACATGACATGCACACAC
CCATAAACACACACACAAAGAAACAGGCTAAAAAGAAAGTGATAGCAACTGGATCATTAAAGGCCATCGTGTATCCTGTTAATCTCATCT
TTTCTGCTACTTCTTTCATTCCAATAGCGATGGCAGACTTTTTTCAGGGGGAATAATTACTCTTCGGGATATATAAATGGAGCAGAAAGG
TGGCGGGCAAATTTAAACAACTGGAATTGGGGGCCAGGTTCTTCAGGGGAAAGGAAGTTTGAAGAAGCTTTCACCAAAAGAAAAAAATAT
AGAAGGGGCTTATCTAACAATCAGAATAGCCTGCAATATGAGAACTAGAGGATTATTTCCTTTAAAAAAAATAACTTAAAAGATCTGTGG
GCCACAATAACCTAATAAGCAAGGACATGTTGGGATGTGAGGACGGCTGTGCAGGTGAGCACTTGGCAGCTGCCACTGGTGTTTTCACCC
AGGTACAGGCAGACGGTGTTCCATTAAAGGAGCAGGCAAAAGAGAGCTGTCAATTTGCTTGCTGTTGAAATGTACATATTTATGCATAAT
TTATAATCATGCTAATGTATTATCTAGAAGTAAGTTGTGAAAGAAAAAAGAGAAACCCAATCTCAAGTTGCCCAACTGATTAGAAATGCC
ATCTCCTTCCCCTAATACACTCCCTCTCCCTGGGGAGTTTGAGTTTCTTCTGTTGGCTCCTTTGCTGTTTGTGTAAATGCTACAGTATAA
TTGTCCCCTCCAATGATTCATGCAGCAATCAAGAGACTACCAGCAAGGAAACTCTAAAAGGAATCCTGGAAGTGGAACAAGTCACTCGTA
AAGGTGTTTCCATTTTACCAGTCAATGCTAACTGGACCACAGCTAACTTGATCTTCAATGCCAACATCACAGAGCCCCTTTCGCCACCTC
AAAAACTGCACAAACATGGACAACCCAGAAACCCAAAACTTTATTGATTAAAACAGATTTTGGATTCTCCTAGGACCTGCTCCAAATTCC
ATCAAGAAAAGCTCCCTGCGAAGAGAAGTTAACAAGATAACATATGATGGATGCTAAATATTTAAATATATGCCGGCAGCGGTTACATAA
GGCCTGCTCAGTTCTGAGATCTATAATTGGGAGGGTCTAACTAGGACAGGGAAAATATAAAATAAAAGTAATCTTCCAGAGTGGAACAAA
AAAGAAATATATTCATCCGACAGTCGTAACACCATTCATGTGCAGTGATTTTTTTATAGTTTTATAATTTTGTATTGTTTTATAAATTAT
TTATAAGGTGTTGTAATGCTTCTTATATTAATTTTTTACAGATAAATTTTTTGCTACAAGGCATAAAAAGGTGCCTGAACCGATTCTTAG
GAATATAAATTATACTGTGTAACTCATAAGTCTTTGGGACCACACCTAATGCTTAATTTTATGATGACATTTCTCATGTCTACTTGTAAA
CAACTTCATATGCCAATGGCGTTTAAGTGTCTTTTATGTTTCCATGAACTGAAGGTTAAGGTTGCCACCCACAAAAAATAAAAGCCACTT
TGGGCATATGTGATTGTATTTCAAGCTTCAGTATTTTTCTCACATAATTTTTAATTATTGTTATCTGCATTTTCATTACTTCATGAAAAA
ATGACAGTGGATATTACATTTTACACTTGTTTATAGATTTTCTTTCTTTTTCAACCAAGAAAATATTTTGAACAATTGAAACTTTTAATT
GCATTTGCAAGGTTTTGGCTTCTTTATGTTGTCATCACACAGATGCACACACACATACACATACAACACAAAAGAGAGAACAAAAAAGCA
AAAGGAGCTAGGAAAAAAACAAAACAAAACAAGTAGAGGTGTATCAAAGAACTCAAGCTATAACCAAAAAGAAATCGTAAAATGCCTTTG
CTCGTTTCTCTACGCTGGACCAAAGCTCAATATTTGTAGGTATATGCACATTGTATAGATATGGCTAAATGTTGCTGACAATCTCGCAAT
ACTAAACTGTTCCTATTTTAAGAAAAAAAAAAGAAATACAAACTGTTCATCAATGTTTTACCTCAGCACTCTACTTGTACCCAGTTAATG
ACCAAGCTTAAAAAAAAATTGAGATAAAGGAAATTGATTTTCATTTCAATGTTTGACTGTAAAATCTGTTTGGATAACATTTTGTAATGA
GCTTTTTGTCATGTGATTTGCTTGTCTTCAACTTGAAATTATGTGAGGCACATTTGTTTATTTGTTGTTAAGAAAGTGATTTTTTTTTTT
TTTTGTCCTATGTGCTGTGATCTAGACTGGTCACCGGGGTCACTTATGAGGCACCACAAAGAGATCTGCTTCTCCGTGCCCGGAGCAGGC
AGCAGGAGGGAGGGCAGGAAACAGGACTGGGTTGCTTTGGAAAAATCATCATGACAAGAAGTTGACATGATAGACTTGTGACCAAGAAGC
CAAACTGAATATTTAAAAGCTCCTTACTTGCTCTGACATTGAAACCAAAGCTGATTTTATCTGCACAGGTTGCTTAATATTTAAAAAAAA
AAAAAACTGTACTTAATCTAGAGCAATATCTGTATGGTCAGTAAAGCTGCACTTTGTGTATTTCTTAACAGCTTCAGATCTGTCACTTTT

>4834_4834_4_ANLN-POU6F2_ANLN_chr7_36483471_ENST00000396068_POU6F2_chr7_39125460_ENST00000518318_length(amino acids)=1638AA_BP=6
MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVES
TSAKSCSPSPVSPQVQPQAADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKA
ASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLN
KALSSSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKD
KSTTPGGTGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSA
EKGGNSKSKQLETKQETHCQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKEVIREIEMSVDDDDINSSKVINDLFSDVLEEGE
LDMEKSQEEMDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPRLELKDTSRSDESPKPGKFQRTRVPRAESGDSLGSEDR
DLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKMQELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEA
EAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCSTVQKPDAANYYYLIILKAGAENMVATP
LASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTSKSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTS
NFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKD
PMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPSKLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLL
TAQQLASAVAGVMPGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQQLQLQLQ
QQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTSQLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPS
QSPGHGLPSPLTPPNPLQLVNNPLASQAAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQ
VQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSVGQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSS
SALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMA
EAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANLN-POU6F2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneANLNchr7:36483471chr7:39125460ENST00000265748+22241_1551026.01125.0CD2AP
HgeneANLNchr7:36483471chr7:39125460ENST00000396068+21231_155989.01088.0CD2AP
HgeneANLNchr7:36483471chr7:39125460ENST00000265748+2224231_6761026.01125.0F-actin
HgeneANLNchr7:36483471chr7:39125460ENST00000396068+2123231_676989.01088.0F-actin


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANLN-POU6F2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANLN-POU6F2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource