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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANO4-ALDOA (FusionGDB2 ID:4890)

Fusion Gene Summary for ANO4-ALDOA

check button Fusion gene summary
Fusion gene informationFusion gene name: ANO4-ALDOA
Fusion gene ID: 4890
HgeneTgene
Gene symbol

ANO4

ALDOA

Gene ID

121601

112694756

Gene nameanoctamin 4uncharaterized LOC112694756
SynonymsTMEM16DALDA|ALDOA
Cytomap

12q23.1

-

Type of geneprotein-codingprotein-coding
Descriptionanoctamin-4transmembrane protein 16Duncharaterized LOC112694756Fructose-bisphosphate aldolase ALung cancer antigen NY-LU-1Muscle-type aldolase
Modification date2020031320200303
UniProtAcc

Q32M45

P04075

Ensembl transtripts involved in fusion geneENST00000299222, ENST00000392977, 
ENST00000392979, ENST00000538618, 
ENST00000550015, ENST00000551148, 
ENST00000338110, ENST00000395248, 
ENST00000395240, ENST00000412304, 
ENST00000563060, ENST00000564546, 
ENST00000564595, ENST00000566897, 
ENST00000569545, ENST00000569798, 
ENST00000575627, 
Fusion gene scores* DoF score4 X 4 X 2=3216 X 16 X 6=1536
# samples 418
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/1536*10)=-3.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANO4 [Title/Abstract] AND ALDOA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANO4(101412510)-ALDOA(30079995), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANO4

GO:0006821

chloride transport

22946059


check buttonFusion gene breakpoints across ANO4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALDOA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG990377ANO4chr12

101412510

-ALDOAchr16

30079995

+


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Fusion Gene ORF analysis for ANO4-ALDOA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000299222ENST00000338110ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000299222ENST00000395248ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000392977ENST00000338110ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000392977ENST00000395248ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000392979ENST00000338110ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000392979ENST00000395248ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000538618ENST00000338110ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000538618ENST00000395248ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000550015ENST00000338110ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000550015ENST00000395248ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000551148ENST00000338110ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-3CDSENST00000551148ENST00000395248ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000395240ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000412304ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000563060ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000564546ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000564595ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000566897ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000569545ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000569798ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000299222ENST00000575627ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000395240ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000412304ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000563060ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000564546ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000564595ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000566897ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000569545ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000569798ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392977ENST00000575627ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000395240ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000412304ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000563060ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000564546ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000564595ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000566897ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000569545ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000569798ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000392979ENST00000575627ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000395240ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000412304ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000563060ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000564546ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000564595ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000566897ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000569545ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000569798ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000538618ENST00000575627ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000395240ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000412304ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000563060ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000564546ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000564595ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000566897ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000569545ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000569798ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000550015ENST00000575627ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000395240ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000412304ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000563060ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000564546ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000564595ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000566897ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000569545ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000569798ANO4chr12

101412510

-ALDOAchr16

30079995

+
intron-intronENST00000551148ENST00000575627ANO4chr12

101412510

-ALDOAchr16

30079995

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANO4-ALDOA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANO4-ALDOA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:101412510/:30079995)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANO4

Q32M45

ALDOA

P04075

FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). {ECO:0000250|UniProtKB:Q8C5H1}.FUNCTION: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANO4-ALDOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANO4-ALDOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANO4-ALDOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANO4-ALDOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource