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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANO4-C12orf66 (FusionGDB2 ID:4891)

Fusion Gene Summary for ANO4-C12orf66

check button Fusion gene summary
Fusion gene informationFusion gene name: ANO4-C12orf66
Fusion gene ID: 4891
HgeneTgene
Gene symbol

ANO4

C12orf66

Gene ID

121601

144577

Gene nameanoctamin 4chromosome 12 open reading frame 66
SynonymsTMEM16D-
Cytomap

12q23.1

12q14.2

Type of geneprotein-codingprotein-coding
Descriptionanoctamin-4transmembrane protein 16DKICSTOR complex protein C12orf66UPF0536 protein C12orf66
Modification date2020031320200313
UniProtAcc

Q32M45

Q96MD2

Ensembl transtripts involved in fusion geneENST00000538618, ENST00000299222, 
ENST00000392977, ENST00000392979, 
ENST00000550015, ENST00000551148, 
ENST00000540673, ENST00000311915, 
ENST00000398055, ENST00000544871, 
Fusion gene scores* DoF score4 X 4 X 2=327 X 3 X 5=105
# samples 48
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/105*10)=-0.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANO4 [Title/Abstract] AND C12orf66 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANO4(101111325)-C12orf66(64609743), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANO4

GO:0006821

chloride transport

22946059


check buttonFusion gene breakpoints across ANO4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C12orf66 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A2QS-01AANO4chr12

101111325

-C12orf66chr12

64609743

-
ChimerDB4SARCTCGA-FX-A2QS-01AANO4chr12

101111325

+C12orf66chr12

64609743

-


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Fusion Gene ORF analysis for ANO4-C12orf66

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000538618ENST00000540673ANO4chr12

101111325

+C12orf66chr12

64609743

-
In-frameENST00000538618ENST00000311915ANO4chr12

101111325

+C12orf66chr12

64609743

-
In-frameENST00000538618ENST00000398055ANO4chr12

101111325

+C12orf66chr12

64609743

-
In-frameENST00000538618ENST00000544871ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000299222ENST00000311915ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000299222ENST00000398055ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000299222ENST00000544871ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000392977ENST00000311915ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000392977ENST00000398055ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000392977ENST00000544871ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000392979ENST00000311915ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000392979ENST00000398055ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000392979ENST00000544871ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000550015ENST00000311915ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000550015ENST00000398055ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000550015ENST00000544871ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000551148ENST00000311915ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000551148ENST00000398055ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-3CDSENST00000551148ENST00000544871ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-intronENST00000299222ENST00000540673ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-intronENST00000392977ENST00000540673ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-intronENST00000392979ENST00000540673ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-intronENST00000550015ENST00000540673ANO4chr12

101111325

+C12orf66chr12

64609743

-
intron-intronENST00000551148ENST00000540673ANO4chr12

101111325

+C12orf66chr12

64609743

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538618ANO4chr12101111325+ENST00000311915C12orf66chr1264609743-24572201193397
ENST00000538618ANO4chr12101111325+ENST00000544871C12orf66chr1264609743-23282201124374
ENST00000538618ANO4chr12101111325+ENST00000398055C12orf66chr1264609743-23262201124374

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538618ENST00000311915ANO4chr12101111325+C12orf66chr1264609743-0.0005575110.9994425
ENST00000538618ENST00000544871ANO4chr12101111325+C12orf66chr1264609743-0.0006440680.999356
ENST00000538618ENST00000398055ANO4chr12101111325+C12orf66chr1264609743-0.0006518950.9993481

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Fusion Genomic Features for ANO4-C12orf66


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANO4-C12orf66


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:101111325/chr12:64609743)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANO4

Q32M45

C12orf66

Q96MD2

FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). {ECO:0000250|UniProtKB:Q8C5H1}.FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127462_4670611.0Compositional biasNote=Poly-Glu
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128462_46701075.0Compositional biasNote=Poly-Glu
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127462_46701107.6666666666667Compositional biasNote=Poly-Glu
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115462_4670716.3333333333334Compositional biasNote=Poly-Glu
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+1271_3520611.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127374_4240611.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127446_5050611.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127527_5470611.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127569_5950611.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127617_7150611.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127737_7680611.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127790_8850611.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127907_9550611.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+1281_35201075.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128374_42401075.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128446_50501075.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128527_54701075.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128569_59501075.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128617_71501075.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128737_76801075.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128790_88501075.0Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128907_95501075.0Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+1271_35201107.6666666666667Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127374_42401107.6666666666667Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127446_50501107.6666666666667Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127527_54701107.6666666666667Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127569_59501107.6666666666667Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127617_71501107.6666666666667Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127737_76801107.6666666666667Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127790_88501107.6666666666667Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127907_95501107.6666666666667Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+1151_3520716.3333333333334Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115374_4240716.3333333333334Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115446_5050716.3333333333334Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115527_5470716.3333333333334Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115569_5950716.3333333333334Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115617_7150716.3333333333334Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115737_7680716.3333333333334Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115790_8850716.3333333333334Topological domainCytoplasmic
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115907_9550716.3333333333334Topological domainExtracellular
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127353_3730611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127425_4450611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127506_5260611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127548_5680611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127596_6160611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127716_7360611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127769_7890611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000299222+127886_9060611.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128353_37301075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128425_44501075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128506_52601075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128548_56801075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128596_61601075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128716_73601075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128769_78901075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392977+128886_90601075.0TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127353_37301107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127425_44501107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127506_52601107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127548_56801107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127596_61601107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127716_73601107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127769_78901107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000392979+127886_90601107.6666666666667TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115353_3730716.3333333333334TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115425_4450716.3333333333334TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115506_5260716.3333333333334TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115548_5680716.3333333333334TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115596_6160716.3333333333334TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115716_7360716.3333333333334TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115769_7890716.3333333333334TransmembraneHelical
HgeneANO4chr12:101111325chr12:64609743ENST00000550015+115886_9060716.3333333333334TransmembraneHelical


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Fusion Gene Sequence for ANO4-C12orf66


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4891_4891_1_ANO4-C12orf66_ANO4_chr12_101111325_ENST00000538618_C12orf66_chr12_64609743_ENST00000311915_length(transcript)=2457nt_BP=22nt
ATGGCCTCCCTCACCGCATACGGGGGCCAGTCTTTCTTCAGCAGGAAGGATTCCATCCGCACCATCTATACTTCATTGCATAATGAGCTG
AAGAAGGTGGTGACTGGCCGTGGTGCCCTGGGTGGGACTGCTCCTCACGTGGAAGAACTCCTTTCCCACCTGTCAGAGCAGCTCTGCTTC
TTTGTTCAGGCTCGGATGGAGATGGCAGACTTCTATGAGAAGATGTACACCCTCAGCACACAGAAGTTCATCAATGCTGAAGAGCTCGTT
GGCCTTTTGGATGCCATCATGAAAAAATACAGCTCCAGATTTCACCACCCAATCCTCAGTCCTTTGGAAAGCAGTTTCCAGCTGGAAGTT
GACGTCCTGTGTCATCTCCTGAAAGCCCAGGCCCAGGTCTCAGAGTGGAAGTTCCTCCCATCTCTGGTTAATTTACACAGTGCGCACACC
AAACTGCAGACGTGGGGCCAGATCTTTGAGAAACAGCGGGAGACCAAGAAACATCTGTTTGGAGGGCAGTCTCAGAAGGCCGTGCAGCCT
CCACACCTTTTCCTTTGGCTGATGAAACTCAAAAACATGCTTCTTGCCAAGTTTAGCTTTTACTTTCATGAGGCTCTGAGCCGACAAACG
ACTGCTTCAGAAATGAAAACGTTGACAGCAAAAGCTAACCCAGACTTTTTTGGAAAGATTTCCAGCTTCATCAGAAAATATGATGCTGCC
AATGTGTCCTTAATTTTTGACAACAGAGGTTCTGAGAGTTTTCAGGGTCATGGTTATCACCACCCCCATTCCTACAGAGAGGCCCCCAAG
GGTGTGGACCAGTATCCAGCTGTAGTGTCTCTGCCCAGCGACAGGCCAGTCATGCACTGGCCCAATGTCATCATGATCATGACGGACCGC
ACATCTGATCTGAACAGCTTGGAGAAAGTGGTCCACTTCTATGATGACAAAGTTCAGAGTACCTACTTCCTAACCCGCCCGGAACCTCAC
TTTACCATTGTCATCATTTTTGAGTCAAAGAAATCTGAGAGAGACTCCCACTTTATTTCCTTCCTCAATGAGGTCTCACTTGCCCTTAAG
AACCCCAAAGTGTTTGCAAGTCTGAAACCTGGAGCCAAAGGTTCCTGTTACCAATGCAATTATTTCGTGGCCTTTTGCCTGAATTATTCT
AAGCTGCTTCTCCAGAGGAAATGAGTCAGAAGAAATAGGCTTGATGTGCATTTCTGCCTTTGGAGACTTCTCTTGATATGGTGTAAATCC
GTAAGGTTTCATTAATGCCTTGTCTGCATATTTTTTCAATCTGCTTTTGATAACAAGGTCTGTTTCTAGGGTACTTCAAATTTAAAACCG
TAGGGTATGTGTAAAATATCACCACTAGAAAATGGAGAGATGCAAATGGGTTCCCCCTTCTGTAGTCCCTCCTAATGTCAGAATCTGGGG
TTAGGGTTCTAAGTGATGGTAGCACTCAGGAGAGGGTCACAAGAGGCAATGACATGGGACTGCATCCTGAAAGATGACTGCTTAGACGTG
CGGCGAGAATGGCCGGAAAACGGAGGATGGCGCTTGACATTGATCTAGGAAAGGAAGACAGTCATTGGGACTTTTGCTAACTTTGTCCCT
AGAGAGTGAATTCTGCTTTTGCTGGTCCTAAAAACTGTAGAGTAATTCTACAATCCAGTTAAATTTGTAAATCTAATGCCTGATTCAGTC
TGAGATTTATGACTCAGCCGGTTGATCCAGCTTAGGTCTAGACTCATTTCACTTTTGTTATGACAAGATACGACAATGTAGGGCACACCC
TTTACCCCCCAGGGTCATCCTGATGTCAGTCATTTCAGGCTAGGCCAGTGTCAGAGCAGTCCCTGAAGCAGAAGTGGATGGAAAGAGGTG
AATGATTTCTAATATTCAACATTCATTAATTTAACATCAACTATGTTAAGGGTAATGATATAGCAGTTAACCAAGACCAACATGGTGTCT
GCTTGGTTGATGCTTGAAATAAGGTGACCTGGCCCCAGCCACCCGGGTGGCCAGGAGCTGAAAGGGCTGTAACAAGTAGGCAGTGAATAG
TCTTCAAACTTGTTACTTGCATACCTCCCTACAAATTTTGGAAAAACCATGAGACTCTGATTGATTTTTTAAAAGAATATCTAAAATCAT
TATGTTTAAATAGCCTCAAAAGAAGCATTTTATTATGTATTGTAAATATTGGCATTTTAAAATGTTATTCGGTCTTTTAAATGTATCCAG
TGAAATGTTGGTACAATAGAGTTTTGATAGCTACCATTTTCCATTTTTAAAAATACTTTAACACGCTTTGTAACAGTTGGAAATATTGTT
TGATTCCTTTTGCTCCCTGAACTCCATTCTTCTTCTTCTGAAGAATTTTATCCTAAAATGAATTTATTTTTTGCTTAACAGTCTTATTGG

>4891_4891_1_ANO4-C12orf66_ANO4_chr12_101111325_ENST00000538618_C12orf66_chr12_64609743_ENST00000311915_length(amino acids)=397AA_BP=7
MASLTAYGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGALGGTAPHVEELLSHLSEQLCFFVQARMEMADFYEKMYTLSTQKFINAEELV
GLLDAIMKKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKAVQP
PHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPK
GVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIFESKKSERDSHFISFLNEVSLALK

--------------------------------------------------------------
>4891_4891_2_ANO4-C12orf66_ANO4_chr12_101111325_ENST00000538618_C12orf66_chr12_64609743_ENST00000398055_length(transcript)=2326nt_BP=22nt
ATGGCCTCCCTCACCGCATACGGGGGCCAGTCTTTCTTCAGCAGGAAGGATTCCATCCGCACCATCTATACTTCATTGCATAATGAGCTG
AAGAAGGTGGTGACTGGCCGTGGTGCCCTGGGTGGGACTGCTCCTCACGTGGAAGAACTCCTTTCCCACCTGTCAGAGCAGCTCTGCTTC
TTTGTTCAGGCTCGGATGGAGATGGCAGACTTCTATGAGAAGATGTACACCCTCAGCACACAGAAGTTCATCAATGCTGAAGAGCTCGTT
GGCCTTTTGGATGCCATCATGAAAAAATACAGCTCCAGATTTCACCACCCAATCCTCAGTCCTTTGGAAAGCAGTTTCCAGCTGGAAGTT
GACGTCCTGTGTCATCTCCTGAAAGCCCAGGCCCAGGTCTCAGAGTGGAAGTTCCTCCCATCTCTGGTTAATTTACACAGTGCGCACACC
AAACTGCAGACGTGGGGCCAGATCTTTGAGAAACAGCGGGAGACCAAGAAACATCTGTTTGGAGGGCAGTCTCAGAAGGCCGTGCAGCCT
CCACACCTTTTCCTTTGGCTGATGAAACTCAAAAACATGCTTCTTGCCAAGTTTAGCTTTTACTTTCATGAGGCTCTGAGCCGACAAACG
ACTGCTTCAGAAATGAAAACGTTGACAGCAAAAGCTAACCCAGACTTTTTTGGAAAGATTTCCAGCTTCATCAGAAAATATGATGCTGCC
AATGTGTCCTTAATTTTTGACAACAGAGGTTCTGAGAGTTTTCAGGGTCATGGTTATCACCACCCCCATTCCTACAGAGAGGCCCCCAAG
GGTGTGGACCAGTATCCAGCTGTAGTGTCTCTGCCCAGCGACAGGCCAGTCATGCACTGGCCCAATGTCATCATGATCATGACGGACCGC
ACATCTGATCTGAACAGCTTGGAGAAAGTGGTCCACTTCTATGATGACAAAGTTCAGAGTACCTACTTCCTAACCCGCCCGGAACCTCAC
TTTACCATTGTCATCATTTTTGAGTCAAAGAAATCTGAGAGAGACTCCCACTTTATTTCCTTCCTCAATGAGGTCTCACTTGCCCTTAAG
AACCCCAAAGTGTTTGCAAGTCTGAAACCTGGAGCCAAAGGTTAGCAGGTGATTTGCGTGGAGGGGTTTCAAGACTAGAAACTGTTCTTA
ATTGCCCTAATGATCTACGGTGGTCTGTGAATAGAGTTTACATCCATTCATGCCTCTTTCAGAACTAAATTAAAGACAAATCCTCCCTGT
GTTGCACACTTTATAAGCAATTAAGGCCAATTGAATTAAGTTTCCAAAGAGTAATCTAGGAAGTGGTCATGGGCTACCATGTGTCTCCAT
GGTACAGCAAAGTAGTTTCAGTATTTTCCCCTATTTTGCTATATTTCTTGTAGATTGAATATTTATTGGGCTTTTTTTTTTCCCATATGT
TTTTCTGTTGTTCTAAACATTGTGTTCTACTGCAATTCCAAACAGCCTCTCTGTTTCCCTCCTTCTTGGAAGAGTAATAGGGATGAGATA
TTAAATGGCCTTTTTAGAATTAAGAACTATATGTTTTCTGTCTCATAAATTAGCAAATGAATATGGAGTTAGTAGATTTATGATTCTGAT
CTACAAATTAACATTTTTGATGCCAAAATTAGGGTCTTGGTAAGAAATTTCTATCAGTTATTGAAACTGAAAGTGAGTCAGATTGGTAGC
ATGACGTAAGGTTTTAACAGTTCAGAAGATCCTCATGGCAGCTTTAATAGCCATGGGTTCTTTTGGGGTAATGTACACACCTAACTGCAT
TTGTTTTGACTTCTTTAATGTTTGAATGTTTCACTCTGTTGTAAAGTCAGCATAAGCCATCATGTGGGCTTTCTTCATTCTTCAGCATAT
TATCCGCTTCGCTTTCTGTTTATCACTTTTCTGCTGAAATGTACATGTTTGGCTCTACTCCTTGGTTATTTTTAGGCTTAAAAGCATGCA
GTCGGTTTTTCAGCCACTTTTAGATACTCATGCAACATAGCCTACTTTTATAAAATCAAAATGAAGGTCTTCATACGCTGTACTTGCTAA
AAATCAACTGTGCGCTTGAAAGACCTCTTCATAGTTGAGTAATCACCTCAGTACTTAAGCACTTCTGAACTTGGGTTTCATGCCTGCCCC
CCACAAATTATGTTTAGAAGCAGCACTGCATCTTAGCACATGCTGCCTTATTTCTTTCCTTCGGCAGGTGTTCATGGGAAGTAGGTGGAT

>4891_4891_2_ANO4-C12orf66_ANO4_chr12_101111325_ENST00000538618_C12orf66_chr12_64609743_ENST00000398055_length(amino acids)=374AA_BP=7
MASLTAYGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGALGGTAPHVEELLSHLSEQLCFFVQARMEMADFYEKMYTLSTQKFINAEELV
GLLDAIMKKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKAVQP
PHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPK
GVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIFESKKSERDSHFISFLNEVSLALK

--------------------------------------------------------------
>4891_4891_3_ANO4-C12orf66_ANO4_chr12_101111325_ENST00000538618_C12orf66_chr12_64609743_ENST00000544871_length(transcript)=2328nt_BP=22nt
ATGGCCTCCCTCACCGCATACGGGGGCCAGTCTTTCTTCAGCAGGAAGGATTCCATCCGCACCATCTATACTTCATTGCATAATGAGCTG
AAGAAGGTGGTGACTGGCCGTGGTGCCCTGGGTGGGACTGCTCCTCACGTGGAAGAACTCCTTTCCCACCTGTCAGAGCAGCTCTGCTTC
TTTGTTCAGGCTCGGATGGAGATGGCAGACTTCTATGAGAAGATGTACACCCTCAGCACACAGAAGTTCATCAATGCTGAAGAGCTCGTT
GGCCTTTTGGATGCCATCATGAAAAAATACAGCTCCAGATTTCACCACCCAATCCTCAGTCCTTTGGAAAGCAGTTTCCAGCTGGAAGTT
GACGTCCTGTGTCATCTCCTGAAAGCCCAGGCCCAGGTCTCAGAGTGGAAGTTCCTCCCATCTCTGGTTAATTTACACAGTGCGCACACC
AAACTGCAGACGTGGGGCCAGATCTTTGAGAAACAGCGGGAGACCAAGAAACATCTGTTTGGAGGGCAGTCTCAGAAGGCCGTGCAGCCT
CCACACCTTTTCCTTTGGCTGATGAAACTCAAAAACATGCTTCTTGCCAAGTTTAGCTTTTACTTTCATGAGGCTCTGAGCCGACAAACG
ACTGCTTCAGAAATGAAAACGTTGACAGCAAAAGCTAACCCAGACTTTTTTGGAAAGATTTCCAGCTTCATCAGAAAATATGATGCTGCC
AATGTGTCCTTAATTTTTGACAACAGAGGTTCTGAGAGTTTTCAGGGTCATGGTTATCACCACCCCCATTCCTACAGAGAGGCCCCCAAG
GGTGTGGACCAGTATCCAGCTGTAGTGTCTCTGCCCAGCGACAGGCCAGTCATGCACTGGCCCAATGTCATCATGATCATGACGGACCGC
ACATCTGATCTGAACAGCTTGGAGAAAGTGGTCCACTTCTATGATGACAAAGTTCAGAGTACCTACTTCCTAACCCGCCCGGAACCTCAC
TTTACCATTGTCATCATTTTTGAGTCAAAGAAATCTGAGAGAGACTCCCACTTTATTTCCTTCCTCAATGAGGTCTCACTTGCCCTTAAG
AACCCCAAAGTGTTTGCAAGTCTGAAACCTGGAGCCAAAGGTTAGCAGGTGATTTGCGTGGAGGGGTTTCAAGACTAGAAACTGTTCTTA
ATTGCCCTAATGATCTACGGTGGTCTGTGAATAGAGTTTACATCCATTCATGCCTCTTTCAGAACTAAATTAAAGACAAATCCTCCCTGT
GTTGCACACTTTATAAGCAATTAAGGCCAATTGAATTAAGTTTCCAAAGAGTAATCTAGGAAGTGGTCATGGGCTACCATGTGTCTCCAT
GGTACAGCAAAGTAGTTTCAGTATTTTCCCCTATTTTGCTATATTTCTTGTAGATTGAATATTTATTGGGCTTTTTTTTTTCCCATATGT
TTTTCTGTTGTTCTAAACATTGTGTTCTACTGCAATTCCAAACAGCCTCTCTGTTTCCCTCCTTCTTGGAAGAGTAATAGGGATGAGATA
TTAAATGGCCTTTTTAGAATTAAGAACTATATGTTTTCTGTCTCATAAATTAGCAAATGAATATGGAGTTAGTAGATTTATGATTCTGAT
CTACAAATTAACATTTTTGATGCCAAAATTAGGGTCTTGGTAAGAAATTTCTATCAGTTATTGAAACTGAAAGTGAGTCAGATTGGTAGC
ATGACGTAAGGTTTTAACAGTTCAGAAGATCCTCATGGCAGCTTTAATAGCCATGGGTTCTTTTGGGGTAATGTACACACCTAACTGCAT
TTGTTTTGACTTCTTTAATGTTTGAATGTTTCACTCTGTTGTAAAGTCAGCATAAGCCATCATGTGGGCTTTCTTCATTCTTCAGCATAT
TATCCGCTTCGCTTTCTGTTTATCACTTTTCTGCTGAAATGTACATGTTTGGCTCTACTCCTTGGTTATTTTTAGGCTTAAAAGCATGCA
GTCGGTTTTTCAGCCACTTTTAGATACTCATGCAACATAGCCTACTTTTATAAAATCAAAATGAAGGTCTTCATACGCTGTACTTGCTAA
AAATCAACTGTGCGCTTGAAAGACCTCTTCATAGTTGAGTAATCACCTCAGTACTTAAGCACTTCTGAACTTGGGTTTCATGCCTGCCCC
CCACAAATTATGTTTAGAAGCAGCACTGCATCTTAGCACATGCTGCCTTATTTCTTTCCTTCGGCAGGTGTTCATGGGAAGTAGGTGGAT

>4891_4891_3_ANO4-C12orf66_ANO4_chr12_101111325_ENST00000538618_C12orf66_chr12_64609743_ENST00000544871_length(amino acids)=374AA_BP=7
MASLTAYGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGALGGTAPHVEELLSHLSEQLCFFVQARMEMADFYEKMYTLSTQKFINAEELV
GLLDAIMKKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKAVQP
PHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPK
GVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIFESKKSERDSHFISFLNEVSLALK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANO4-C12orf66


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANO4-C12orf66


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANO4-C12orf66


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource