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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABL1-NTRK2 (FusionGDB2 ID:490)

Fusion Gene Summary for ABL1-NTRK2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABL1-NTRK2
Fusion gene ID: 490
HgeneTgene
Gene symbol

ABL1

NTRK2

Gene ID

25

4915

Gene nameABL proto-oncogene 1, non-receptor tyrosine kinaseneurotrophic receptor tyrosine kinase 2
SynonymsABL|BCR-ABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-ablEIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

9q34.12

9q21.33

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1truncatedBDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020032720200313
UniProtAcc

P00519

Q16620

Ensembl transtripts involved in fusion geneENST00000318560, ENST00000277120, 
ENST00000304053, ENST00000323115, 
ENST00000359847, ENST00000376208, 
ENST00000376213, ENST00000376214, 
ENST00000395866, ENST00000395882, 
Fusion gene scores* DoF score21 X 55 X 13=1501510 X 9 X 7=630
# samples 6810
** MAII scorelog2(68/15015*10)=-4.46472591830681
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABL1 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABL1(133710912)-NTRK2(87338487), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABL1

GO:0006974

cellular response to DNA damage stimulus

15657060

HgeneABL1

GO:0006975

DNA damage induced protein phosphorylation

18280240

HgeneABL1

GO:0018108

peptidyl-tyrosine phosphorylation

7590236|9144171|10713049|11121037

HgeneABL1

GO:0038083

peptidyl-tyrosine autophosphorylation

10518561

HgeneABL1

GO:0042770

signal transduction in response to DNA damage

9037071|15657060

HgeneABL1

GO:0043065

positive regulation of apoptotic process

9037071

HgeneABL1

GO:0046777

protein autophosphorylation

10713049

HgeneABL1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

15657060

HgeneABL1

GO:0051353

positive regulation of oxidoreductase activity

12893824

HgeneABL1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

20823226

HgeneABL1

GO:0070301

cellular response to hydrogen peroxide

10713049

HgeneABL1

GO:0071103

DNA conformation change

9558345

HgeneABL1

GO:0071901

negative regulation of protein serine/threonine kinase activity

11121037

HgeneABL1

GO:1990051

activation of protein kinase C activity

10713049

HgeneABL1

GO:2001020

regulation of response to DNA damage stimulus

9461559


check buttonFusion gene breakpoints across ABL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EWABL1chr9

133710912

+NTRK2chr9

87338487

+


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Fusion Gene ORF analysis for ABL1-NTRK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000318560ENST00000277120ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000304053ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000323115ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000359847ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000376208ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000376213ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000376214ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000395866ABL1chr9

133710912

+NTRK2chr9

87338487

+
In-frameENST00000318560ENST00000395882ABL1chr9

133710912

+NTRK2chr9

87338487

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318560ABL1chr9133710912+ENST00000376214NTRK2chr987338487+45474602702393707
ENST00000318560ABL1chr9133710912+ENST00000376213NTRK2chr987338487+44994602702345691
ENST00000318560ABL1chr9133710912+ENST00000395882NTRK2chr987338487+64384602701310346
ENST00000318560ABL1chr9133710912+ENST00000304053NTRK2chr987338487+76204602701538422
ENST00000318560ABL1chr9133710912+ENST00000376208NTRK2chr987338487+75724602701490406
ENST00000318560ABL1chr9133710912+ENST00000277120NTRK2chr987338487+34514602702393707
ENST00000318560ABL1chr9133710912+ENST00000323115NTRK2chr987338487+32324602702345691
ENST00000318560ABL1chr9133710912+ENST00000359847NTRK2chr987338487+64344602701310346
ENST00000318560ABL1chr9133710912+ENST00000395866NTRK2chr987338487+17954602701310346

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318560ENST00000376214ABL1chr9133710912+NTRK2chr987338487+0.0013605440.9986394
ENST00000318560ENST00000376213ABL1chr9133710912+NTRK2chr987338487+0.0015985280.99840146
ENST00000318560ENST00000395882ABL1chr9133710912+NTRK2chr987338487+0.0008531470.9991468
ENST00000318560ENST00000304053ABL1chr9133710912+NTRK2chr987338487+0.0006861330.99931383
ENST00000318560ENST00000376208ABL1chr9133710912+NTRK2chr987338487+0.0007339110.9992661
ENST00000318560ENST00000277120ABL1chr9133710912+NTRK2chr987338487+0.0018912090.99810874
ENST00000318560ENST00000323115ABL1chr9133710912+NTRK2chr987338487+0.002284490.9977155
ENST00000318560ENST00000359847ABL1chr9133710912+NTRK2chr987338487+0.0008154420.99918455
ENST00000318560ENST00000395866ABL1chr9133710912+NTRK2chr987338487+0.0006708470.9993292

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Fusion Genomic Features for ABL1-NTRK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABL1chr9133710912+NTRK2chr987338487+4.11E-050.999959
ABL1chr9133710912+NTRK2chr987338487+4.11E-050.999959

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABL1-NTRK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:133710912/chr9:87338487)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABL1

P00519

NTRK2

Q16620

FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+11118_22261131.0Compositional biasNote=Poly-Ser
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519197_282194839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519295_365194839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519538_807194839.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515197_282194554.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515295_365194554.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515538_807194554.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417197_282194823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417295_365194823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417538_807194823.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412197_282194478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412295_365194478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412538_807194478.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514197_282194538.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514295_365194538.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514538_807194538.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720197_282194823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720295_365194823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720538_807194823.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721197_282194839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721295_365194839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721538_807194839.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412148_19638322.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412197_28238322.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412295_36538322.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412538_80738322.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513197_282194478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513295_365194478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513538_807194478.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519544_552194839.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515544_552194554.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417544_552194823.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412544_552194478.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514544_552194538.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720544_552194823.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721544_552194839.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412544_55238322.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513544_552194478.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412116_13738322.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039586641292_11338322.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519455_822194839.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515455_822194554.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417455_822194823.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412455_822194478.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514455_822194538.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720455_822194823.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721455_822194839.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412455_82238322.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513455_822194478.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519431_454194839.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515431_454194554.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417431_454194823.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412431_454194478.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514431_454194538.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720431_454194823.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721431_454194839.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412431_45438322.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513431_454194478.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111605_609261131.0Compositional biasNote=Poly-Lys
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111782_1019261131.0Compositional biasNote=Pro-rich
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111897_903261131.0Compositional biasNote=Poly-Pro
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111127_217261131.0DomainSH2
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111242_493261131.0DomainProtein kinase
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+11161_121261131.0DomainSH3
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+1111090_1100261131.0MotifNuclear export signal
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111381_405261131.0MotifNote=Kinase activation loop
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111709_715261131.0MotifNuclear localization signal 2
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111762_769261131.0MotifNuclear localization signal 3
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111248_256261131.0Nucleotide bindingNote=ATP
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111316_322261131.0Nucleotide bindingNote=ATP
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+1111_60261131.0RegionNote=CAP
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111869_968261131.0RegionDNA-binding
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111953_1130261131.0RegionNote=F-actin-binding
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519148_196194839.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000027712051932_61194839.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515148_196194554.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000030405351532_61194554.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417148_196194823.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000032311541732_61194823.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412148_196194478.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000035984741232_61194478.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514148_196194538.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037620851432_61194538.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720148_196194823.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621372032_61194823.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721148_196194839.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621472132_61194839.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039586641232_6138322.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513148_196194478.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039588251332_61194478.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519116_137194839.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000027712051992_113194839.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515116_137194554.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000030405351592_113194554.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417116_137194823.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000032311541792_113194823.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412116_137194478.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000035984741292_113194478.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514116_137194538.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037620851492_113194538.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720116_137194823.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621372092_113194823.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721116_137194839.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621472192_113194839.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513116_137194478.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039588251392_113194478.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST0000027712051932_430194839.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000030405351532_430194554.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000032311541732_430194823.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000035984741232_430194478.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037620851432_430194538.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621372032_430194823.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621472132_430194839.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039586641232_43038322.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039588251332_430194478.0Topological domainExtracellular


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Fusion Gene Sequence for ABL1-NTRK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>490_490_1_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000277120_length(transcript)=3451nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGATTTCTCATGGTTTGGATTTGGGAAAGTAAAATCAAGACAAGGTGTTGGCCCAGCCTCCGTTATCAGCAATGATGAT
GACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATG
ACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGA
CATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGAC
AAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTC
CAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTC
AACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCAT
ATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGG
GAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTG
CCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAG
ATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCC
CGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACC
CTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACT
CCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAA
GACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCT
TTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTT
CTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCC
AGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTT
TGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGC
TTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATT
ATGAACCGCAATATGGGAGGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGG
GAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATC
ACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTC
GTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCC

>490_490_1_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000277120_length(amino acids)=707AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD
DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

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>490_490_2_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000304053_length(transcript)=7620nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGATTTCTCATGGTTTGGATTTGGGAAAGTAAAATCAAGACAAGGTGTTGGCCCAGCCTCCGTTATCAGCAATGATGAT
GACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATG
ACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATGGCCCAGAGGTTCCCCCAAG
ACCGCCTGATAATAATTTGGTATTTGGAGGCTCCTGTGTCACTGCAGGAACTAAAGGAGGCTAAATCCATGCCTGATGGAGGAGAAGAGT
TCTATGGTTATCTGCAAATTCTGGCCAGACAACATCTTGACGTCACTCCTTAGCTTCCATAACCTAGCCAAGCAAGAAGTTGCCTTTCCA
AGACAAAGCAGTGTGCTCTAATGACTAACCCCTCAAAGTACTATGCCACTTTAACTATAGACCCATCTCCTCGATCAATCAGGATGGCAA
GATGGAGCTGAGGAGCTCAGCAACATCAAGTCTGGAGTTGGTCTTTAACTCAACTAGCTCGTTTAGACGTGTCTGAACACCACATCACCT
GACAGCACGGGGTGGTTTCCCAGTAAAATTTACAAACTCAGCTCAAGGGCAGCTGTGTTGCTTTCCTTTCCTTGACTGCTGAGAAACTTT
TTGACAGGGAACAATGGAAACACACCTTCTGAGCTGAAACAAACAAACAGAAACAAAACATACTAACCAGCAAAATCCCCAAATCATCAA
TCTTGGGTTCTCTTGAAGGGCAGGAGTGTGTTTTATCTTCTCCCGTCGGAGCAAACACTATAGATGTCCTCCCTAAAATTCTGTCTTCCC
TAGAGCAGCCTTGTAAATTAGCTAGGGTCCTAGGGTTGAGGCCTAAATCAACTTAAAATTGTCTCTAAATATGTACCTGGATGTGTTTGT
ACTTGCAGAGCATGCCCTCTTCATGTGCCTAGGGCTAGTAACTCCCTGTGGCAGAGGCATGTAAAGTATTCTGACTTTTTTTTTTTCAAC
TTAATTCCATTTCCAATGAAATGGATTTTTAAAAATTTTCTCCAGAGTGTGCCATACTTCTCCAGCTATTATAGTTAATGTGTGTGTATC
CTTGTGTATATGTGTGTTTGTGTGTGCATATGTGTTTTCCTAGTGGTTACATGCTTACTAGGCAATTATGTAAATAAGCACAGATTCATA
GGCCAGCTAGGCCTGAGGAAAGAAGACATTATAAAGGGAGGGAGTATTTTAACATTAGCTAAAGCTATCACACAAGGCACCCATTCTGCT
CCCCTCAACAGCCACAGCCCACTTCGTCCTTGTCTTACCAATAAGGGGAAAGGCTGGAGGTGATATTTTTCACAGAACCGCAGAGGTTTT
GAACATATTTGCAACATTACTTTGAGTACACATGAGCAAAAATTCTGAATTACATCCAGGACCCCAGAAGCTCATTAGATCAAAGAGTGC
GGGGCCCCTCAGAGTTACCAGAGATTATCTGCAGACTTCAGTGCAATCGAATGACCATGGTCCATTTTGATGGTCAGAGGTAGGACTGAA
AAACGGGTAGAAACAATTGCTTTAGCGCTTCCTTCTGTACTTTGCCTATTAATGTTTTGTCTTTCAAAAATATATTTTCTCCTAATTGTT
TAATTGGCCAAATAATGGCTGCTTTGGGAGTTGTTTGTATGCCTTGGAAGGCCATGGCCTGCACTTTAAAAATAAGCTAAGTCCATTCTG
CCCAGCACGAGCATTAGGACAGAGAATGCACTTATTTTAGGATCCTTAAAAATTGCTTCTTTTATGGCACACTGGGTTGACGACTCATCT
CGTGGGAGCCTTCATGGCACATTGCTGCTGTTCTGCAGGTCCCAATACAATTCCTTCCCCCTCTCAGTGCCACGGCCCCCCCATTGCTAG
CTACAACAATTTGATATCATATTCCCTTTTCAACTCCAAAGGAGATGATAAGAAGCTATCAAATAATGCTTTAAAAAAGCAACTTGAGTT
TCTTAAAAGAAAGGAAATGAATACATGCTGCATAATTACATTTAAAATGTAAGCCATGTTATTATAAGCCGCACTGAGATGAAGATTTGT
TAGCAAACCAGTTTCAAGCACACTCACAGTGAAGTAAAATCATGTTTTTAGCATCTGACCATTGGGTAATATTATTCTTTGTTATCAAAA
GAGAAATATCACCCAAGTATAGTATACTTAGACCTCCTAGAGGAAACACTCCAGTCCTAAGCTTGGTGTCTGAAAAGAAAAACAAAAATA
AAGATTATGGATTTAGGTCAGGGAGACAGAGTGATATTCTGAAGACTGTGTTTACTCCCTCATCATCGGCCAACCAAGATGGAGTTCTGC
ATCCTGCACATATCAGACATTTCAGTCCAATTTCACCAAAGCATCAGTGATGTTCTAGAAGCATCCCAGCAGATGGAGGATCCTAATGTA
TTTGTTCTGGGTATTTCCCAAGGCCCAGCCTGACTGGAGTGTGTGTACCAACAGGATGAATCCAATCAAGCTACGCCCCCATTTTGGTTT
CGGATTGGCCACTCTTGCATGTGCTAGTAGATTGTGGACCAGGACCAGCTGAGCAAACACAGTTGCAGAGTAGCCTCCTATGTTGCTAAG
AAGCTCCTGCTACCCAGGTGCTTTGAACAATTGAGTGCTCCCTCTGGTTAAGTAGAGATGGCACCACCGGAGTTTTTCTTGGATGTGAGG
CTCAATCCTTTACGGCAGCTATTATAACAAAGTGAAGGTTTTCTCCCTGGGAAATGCAGCTTTTCTCTGTCTTTACTAATTCTGCCAGCC
TGTGAGAGTAACCACCGTAGCTGGGCTTCTTCTCAGATTAATTGTCATGCCAGGTCTCCTTCCTGGGGAGCTGTGATGCTGCTCTGAGGT
TGATTGCTGAGGTTGTAGTGGGTTTTTGTTTGTTTTTGTTTAGTTTTTCTTGATTGTTCTTCTTTCTCTTGAATGGCAAGAGAAGAAACA
CTTTCTCTAACCCACGGCCAGGAAGGAAATGGGGAGAGAGCTACTTCTTAGTTCAACCTGGTTGCCACATAAAGGAATCTCTCTCCTTGG
ACTCAGCCCCTAACTGGAAGCAAGAGCCACTGCCCTCTGAGACTGAGAGAGCAGCCCGAGGAGGAGATGAATCCATTCTGCCCTTTGTTT
GGGTTTGCTTCCTGTCAGTGAGAGAATGCTGAGGCAGTTCCTGTTATGTGAAACTTTCATTTTTAAAACCAGGACAGTCCTAAACAGACT
GGAATGAGTTGGTCAATCCCAGTTGGTATAGGCCCAATGATTTTTGCTAGTAAGATAGGATTGTCTTCCTCACCCAAAATGCCTTCAAGT
GCCCTAAAATGGGTATTTTAAAATAAGAATAAATAATGTAGATTTAGTAGAAAACCTGGAAAACATAAGAAACAAAGATGAAACGAAAAG
TCCCATGTAATTCCACCAGTTAGAGTTAACCACTGATATCGTTTGGATATATGGCTTTCTAGTCTTGTGGATATCCTTTTAATCTCTTGT
AATATAAAGTCTGACCATATGTGTCCTTGCATTTGTTTGTACTGGACTCTGTTAATATTTCTATAGTAATGGCTCACTTTGGGGAGATTG
TGCTGCACAGTGTGTAGGAAGCACATTGGGTGTATTATTCCCAGTTTTGTATTTTGTATTTCCTTGGAGATGTGCAGGGGTTAAGAGCGG
GGGTCTGGCCATAGCTGGCCACGTCAGACTCTCATATGGTAAGTATCACAGAGCACATGAGGCCTGTGTTATGCGCTGGAAAGACTCAGG
AAATGAGAGGCTCTCTTGTTCTGACAAGGCAGGCTGAGAGCTCTCATTTAGGGTCATCACTCCAGATAACTCCAAATGCAGTTTATTGCT
CAACTGAAGCAGATGATCACTTTTTGCCTCCAAGTTCTTCACCCTAGCTAGCTCCTTTCAAAGAGCCGAGTATGCTGGATCTTAAAGGGC
CAAACTAGTTACATCTCATACATTTCCTGATGTTTAGGGATGCCTTCACTTCCATCAAGGATACCTTGGCTGTGCAAGGACCTCTGATAG
CTGGAGTCTCCTTTTGGTCACTCCCAGCTTTGCTTAAACTTGATGGAGTTTGCTGTCCAGTGATCCCCGGATCTTTCATCATGAAAGCCT
TCCTTCCTCTCCTGATGTCTCAGGCCTCTAGACCTAGACTGGGGTTCTGGCAAGGAGGCCTCTATCAATAGTATGACATCCAATAATATG
TTAGTGTTGATATTTTGCACAGTAATATTAAGTTTAAGAGATTATAAAAATGAGTTCAAATGAATAAGTTCCTGTGATGTAAGAGATTAG
ATATGTGTGATTTCAGAACCAAAGGCAGGGGGGAATCCCAGAAAGAAAACAATAATATAATCCTAGTTTCTATATATTATTTTTATTCAT
TACTGTATATGGGTAGAGATCAATATTCTTTCTTATGCTGTTACTATTAATTAACACATTTTTTAACCATGCCATTGAACTTTTGGGTGC
ATTAAAGTGGAACCCAAGCTCCTCATTAGATAATAATGGCATTTGGACTGAGTGCCATATTCCTAAATTTCCAATAAAGTGGTTGATATA
GAGAGGACAGGATAAAGCCCTATAGTGTGCAGTTATATCAAAACAGCTAGTCTCCACTTTAGGGAATGCCTTTACTAGAGATTACATGAA
ATGTCTGCTTATAAAATAAGCAGAGATGGCACCACTAAGCAGCCACCTGAATTGTTTTCCTACAGGAATGATTACTTTTCAGATCCATTT
ATGTTTTCATGCTCAATACTTACTCCCCTTCCCTGCAACACCCAAAGAGTTTACTTTTGCAAGTCATTTGGTCTTCAGTCTACTACTGAG
GAATAGAGAGGCACTAACTGCTTTACCCAGGATCAGAACTCATGTTCTTACCTTCTATTAATAGAGTACTTGAGCCAGATGGACTAACTG
GTCTCACATTTTCTCTATCTTGGTTTTACTTCCATAAACATCAATATCTTTACCCACATGATTTTTCCATCCTCCCATTTTTTTCCATAT
GTATTAGGGTTCAGGAACTATGATGCTAATGATCACATTTCTTCCTAGTTCCTAATTTCATTAGTGCCATTTCCTGATATCTACAGAAAC
AATTATCAATACATGTAGCTGCTTGAGCCTTATTTAGAAGGCTAGCCTTTCTTTTCCAAGTGCTGTCAGAATGTATACATTTAGTCTGTC
TTTTTCCCTTTTAGGAGTCTTTGTTCTGGGTTGATGGCAAAATTCCTCTTTTTACATGTGAGATTTTTGATTTCACTGAATTCTACCTAG
ATTTTTATGGACATTGGATTTTAAAGAGGAAAACACTCATTTTCTTAGTAAGATATTGGTGATACATAGCTATGCCATTGATTTCCATAC
TCCTGAGCTTTGGGGAGGGAGACAGTGGCCAAGTAGCAGGCAGAATAAGATCATCACTCATGTCCTGAATCAATCACACTTTCCTTCTCG
GATTGTGTATATGCTCTGCCACTTCCTACATATTACATCCTGAGTTTTTAAGTAAAGTGGATCTTAGCCAGATTTGAGTCTAATGGCTGA
TTCATCGGCATAGTTCTTGGCGTTAACATCTCAGTGTCCTCTTTAGTTCTCTTTGAGGATTCATGTCATTGAGGGCCTTTGTGCCTCCAC
TTGTCTCAGTATGAGGAAGAACTTTGGTGTGAGGGCGGAGCTATGTGAAGGGTTGCTGGGTTGGGGGATTAGTTCATATGGTCCCCATGC
CATCTATTTACTTTTGGAGAGAGGGGACTTTGAGTGGGTGGGTATGGATAGATGTTCCTCAAGGAAACCCTGCTGGCTAATGGGCACTAC
ATCTGTGTATTACTGTGATTCTCTCTGTAAGCTCCCCATGTGGCCAAGGACCCCCCTCCTACCAGGGCACTTCCTGCCACCTCATTGCAC
TGGTCTCAACCATTCAGCCTGCTGCTGCTGCACCATGTTGGGCTGCGGTAGGATAGGGAAGGGGTTCTGTTGATTGCTAAATGTTGCCTA
ACTTTATTTCCCTCTCCCACATTTCATGCAAGGGAGCGGACCTAACACATGACTTGCATTCTCTTCCTATGTTCAGAAACTCCAGGGCTT
GCCCACGTGTATGTATGAGTGACCAATGGAGCTTGGAATTCTTTATCTATATGATCTGTCCGAAAATGAGATCTTTTGTACTGGAATTTG

>490_490_2_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000304053_length(amino acids)=422AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD

--------------------------------------------------------------
>490_490_3_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000323115_length(transcript)=3232nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGGCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCA
TCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAAC
AGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAA
GTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCA
CGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGAC
CCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAG
GGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCAC
TTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTG
TACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACG
ACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAG
GTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAG
CGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTA
GGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGC
CACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTCTTCATCCATA
GACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTT
CTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCTGCATAGACA
AAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGA
TGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCT
ATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATCTGTGAAGCCT
TTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGGGATCAGCTGG
TGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCTGAGGAGTAAA

>490_490_3_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000323115_length(amino acids)=691AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP
SSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA
RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQH
FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNE

--------------------------------------------------------------
>490_490_4_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000359847_length(transcript)=6434nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGGTTTTGTTTTGTTTCATAAGATCCCACTGGATGGGTAGCTGAAATAAAGGAAAAGACAGAGAAAGGGGCTGTGGTGC
TTGTTGGTTGATGCTGCCATGTAAGCTGGACTCCTGGGACTGCTGTTGGCTTATCCCGGGAAGTGCTGCTTATCTGGGGTTTTCTGGTAG
ATGTGGGCGGTGTTTGGAGGCTGTACTATATGAAGCCTGCATATACTGTGAGCTGTGATTGGGGAACACCAATGCAGAGGTAACTCTCAG
GCAGCTAAGCAGCACCTCAAGAAAACATGTTAAATTAATGCTTCTCTTCTTACAGTAGTTCAAATACAAAACTGAAATGAAATCCCATTG
GATTGTACTTCTCTTCTGAAAAGTGTGCTTTTTGACCCTACTGGACATTTATTGACTTAATTGCTTCTGTTTATTAAAATTGACCTGCAA
AGTTAAAAAAAAATTAAAGTTGAGAACAGGTATAAGTGCACACTGAATAGTCTAATCTACATGTAACACATATTTTAGTGTGATTTTCTA
TACTCTAATCAGCACTGAATTCAGAGGGTTTGACTTTTTCATCTATAACACAGTGACTAAAAGAGTTAAGGGTATATATACCATCACTTT
GGGACTTGGTAGTATTATTAAAAGGTTATTTCCTTCACTGTCAATAAAAGTCCAAATGTTTAGCTTAGGTCTGAGAGTCAAACAATGTTA
AGGATTGTCTTAAAGTTCCTTAGCCAGCAAAACAAAACAAAACAAAACAAACAAATGAAAAACGTTTAAAAAGAAGAAGAAGAAAAAAAA
CAAGAACAAGCAGCAACAGCTGTTTTGTTGGGGCTATAGATTTAAGTTAGGCATAGTCAATTTCAGAATAACTAAGAGTGGAATATATGC
ATATGGTGAAATTATAACCTTGCCCTTTTTTATTTGCCCTCTGCGATCCACCTGCTTTTTAGAAGTCTGCCGAGTGAGAAGGCCACAGTA
TCTCATGCTGTTTGCATTACAGAACTGCAGCTTTTCTACTCTGAAAAGGCCTGGGAGCAGAATGGCTGGCCTGCTGTGAGCAGGAGAGGA
GATTCTAAGAAGGATAGTCCCCCCTACAACATACTGTCATACTGCTGGGTTTTCATGGGTAGGAAAGCTTGTCCTGACCCCAGCAGCAAA
GAGGTGGCAGGTCGCTAATGAATATATGCTTTATAATGTCCTTCTTCATTGCTGAGAGGGCAGCCTTAGAGCTGTGGATTTCTGCATCCC
CCCTGAGTCTGACCCATGGACACCTGTTTCATTCACTTTAGCATCACAGTGACCTTTGTATGCTCTGTTCAGTCTGTGTCAGGCAGTATG
CTTGTCCTGAAGAGAGGTTTGGCTATCCCCACCCCACCCCACCCCACCCTGTTCCTTTTTTATCAGGAGGACTTCAGAGCCAGGCCTGCA
GCATTTTGTTTGAAAACACAATCAGCTCTGACAGTTAGACATGCACACAGACGCCATAGCTGGATTGGAAACATTGATGTTTTAAAAATT
TATTTTTTTTGGAAATAGTTGCACAAATGCTGCAATTTAGCTTTAAGGTTCTATAGATTTTTAACTAGTCCAACACAGTCAGAAACATTG
TTTTGAATCCTCTGTAAACCAAGGCATTAATCTTAATAAACCAGGATCCATTTAGGTACCACTTGATATAAAAAGGATATCCATAATGAA
TATTTTATACTGCATCCTTTACATTAGCCACTAAATACGTTATTGCTTGATGAAGACCTTTCACAGAATCCTATGGATTGCAGCATTTCA
CTTGGCTACTTCATACCCATGCCTTAAAGAGGGGCAGTTTCTCAAAAGCAGAAACATGCCGCCAGTTCTCAAGTTTTCCTCCTAACTCCA
TTTGAATGTAAGGGCAGCTGGCCCCCAATGTGGGGAGGTCCGAACATTTTCTGAATTCCCATTTTCTTGTTCGCGGCTAAATGACAGTTT
CTGTCATTACTTAGATTCCGATCTTTCCCAAAGGTGTTGATTTACAAAGAGGCCAGCTAATAGCAGAAATCATGACCCTGAAAGAGAGAT
GAAATTCAAGCTGTGAGCCAGGCAGGAGCTCAGTATGGCAAAGGTTCTTGAGAATCAGCCATTTGGTACAAAAAAGATTTTTAAAGCTTT
TATGTTATACCATGGAGCCATAGAAAGGCTATGGATTGTTTAAGAACTATTTTAAAGTGTTCCAGACCCAAAAAGGAAAAATAAAAAAAA
AGGAATATTTGTACCCAACAGCTAGAAGGATTGCAAGGTAGATTTTTGTTTTAAAATGGAGAGAAGTGGACAGATAAGGCCATTTAATAT
ATCAAAGATCAGTTGACATCTCCTAGGGAATGATGAAAACAGCAGGCTATTAGAAAATTATTTCATATAGTTCTCGTGTTCTTTTCTTTT
TTTTAATCCCTGAAGGGATGATCAGTAACATAGCTTCTCTTTTCTGTACTCTAGACCACCCCTTTTCATCATTTTGCTTTTTATGTCTCC
CATAAGAAATGTGCTTTTTAGAGCTTCCTAATGCATGTGTTGCATTATTGCAGCATTAGAAAAGGAGAGGTAGCATTTTTGCTGAAATCG
GGCCTGTCACTCTCCAATAAAGGTTCTGGCACTTCAATGCCAGGCAGGTCTCCTAAATGAACAGAATGATCTGTGTGAGCCGATGCCTGC
CCTTCCAGAGGGGCCACTGTCCCCAGCCGCAGCCAACTGTGTCCCACAGGAATGGGAGCCTAGGTTTCCAAATCTTGTGATTCTTTAGGA
GAAACATGAAACCTGGATTTCGTGTGAAATGTCCCGATTGTTAAAAAGTTGGCTCAATTATTTTTAAAACATTTTGTAAGCCAACAAAAG
TCTGTGGGCTGCCAGTTTATTACTTTTGTCTTAAAACATGATCATTGTTCTCTCACGGTATCCTTCTGTCTTCCCGTTGCAAATTCACTT
TTCTTTCTTCCTGACATTGCCATTGAGGGCTTTGTTACCACAAGCTAAGAAACTGAGTTTAACAGCCCAGTTATCTGCAACATGTCAATT
ACCTTTGCTCCTCTCCTGTGATTCCCACCATGCTGTGACCCTCAGCTGTCTCCCTTTGCTGGGAATTCTGCACCAATGTCTCCCCTCAAC
CCATTCCCTGGTTGGTCCTACTCCCGTGTGGCCAGAGACATCCTAGCAAATCCTTCCTCCTATTATATCTGACACTAATTTCTTTTCAAC
AGCGCTCATGTCTCTTGGCCCAGTCAGGTGCTGCCAGGTTTAGATAGGAAAGTACATGTCCCATTTTCATGGGTGCCCTTAATGTGGTCC
ACGTCCTATATCTTATTATATTTACTCATGGCTCAATGGGGGCCTCCAGAGACCCTCTCAGGCTGCTGAGCTAGACTAAGGAATGCATCC
ACCGTCATCACATGAGACACTGACTCTGTGACGACAAAAGTACAAACAGTCTGAGGCTAAGAAAGGTTCATCTCACAACAGGAAAAACAA
ATCTCAACACACATTAGAGATAATTGATTCAGGGGTTTTCTCTCCCAGTCTCCCAGCAGGGACTGATTTCATTTCTGACCCACTAGGTTT
TCTTTCCAGAAATAGGTAGCAAGGACAAGAACTAAACAATCCCAGCCCCACCCAGCAACACAGAACACAGGAGTTTGCTTTTGGCTTCTC
ACTCTCCAAGTAACCCTGAATTAGGCCCAGAATGGCTGAGGCTTGGAGCATCTCCTCAGACAGAGCAGAGGCGACACCTCTTCAGGGGTG
TGTGGAGTAAATAGCTCGAAGAGCTGAAGACAGAAAACCAGTTTCACGCCAGGTGCGAGAGAGAGCATAATGGAGGGAAGCCCGCTTTCT
CTCTCCTCTTCTTTTCTCTTTATTTCTTTAGAGCACTTGACTTTTTTTTCTCTCTCTCTCTAGTATTCTAAACTGACCCCATGACCAACT
GAGAATTTATTTTTGTTTCATTGGTTGTTTCACAGAATTAGAACACACACGACTTTTTATTCCTCCATTGCAAAATGGAATCAAGATACT
ACACAAGACCTGTGCTTTCTTCCTTTGCATGATTTACACCTCCGCCTGTTTTGGTGCTAGCTGTCTAGAACTTCTCTCTTGGTTTGAATC
TGATTCCTTCACACTACACTAGAAGTTTATTTCATCTTGTTTTGTCTAGACTCCAGATACAGAGGGACAGCTGGACTGAGGACAAGCAAT
TCCATCTAGCATAGGGTCTCTCAGGGTTGGTGCATCCAGCCACATGGGCAGGGCCAGTCACATCTAGTCTATGTCCCCAGAGCCCTTGGA
GTTGCGCAGCTTAGCTGACTTGACTCCAAGGAAATTAGTACAGAAGTAACCACTCTATTAAGTGTGTTCTGCTATGTTCACATGCCTGTA
GTACCTGCAAACCATGCCAGGTTCATCTAAAGACATAGGGGAAGATTAAGGACTCTTTTGGACAGACCATGAATTGAATTTGCTGCCAGG
TGCTGCCAGACTGAATTTGGCTGACAGAACTCCCAGCCCAGGAAAGTTCCATGACAATGACTGTCGCAGAAGGAAATTTCCCACTAAAGT
CAGTCCATTTTCAAGTTTTGGTCTTCAGAGACAAAAGAACGTCCCAGCCACCTGATTTTGATGGTGAGGTAACTCTAAGTTGAATTCAGG
CTAGTGTTGCAGTATAGCTTTGGCATGTTCATGAGTGAGCACCCAGAATGTGTTGAACCAACCCCCACCCCTAACTACTGACTATGACTG
CAGTGGGTTTTTATGGGGAAAAAAAGTGTGAAAAGCAAAAAGAAAGGAACAGAGATTTTTTATCACCTTTATTGTAAGACAGTCCATTTA
TGAATTGAGTATAAACACATACAAAGTAACAAGAGATTCCTAAGAAACGCAAATCCTTGAGTTTCACGCACTTCATGTTCAACCATTTGC
TGTAATCCAGAGGCAGCCTGTGAATCATTCTCATGCCCTGTTTTTTTTTTTTTTTTCCTATAATGTTCTGGGTTTAAAAGCCATCTTTTC
CACATTTTCTGTAAATAATGGATAATCATTTTAAAAATTTTTATTTTTAGTGCTGTTTTAACAATGTAGATAGATCATAAATGTACTTGC

>490_490_4_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000359847_length(amino acids)=346AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG

--------------------------------------------------------------
>490_490_5_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376208_length(transcript)=7572nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGGCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCA
TCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAAC
AGTCAGCTCAAGCCAGACACATGGCCCAGAGGTTCCCCCAAGACCGCCTGATAATAATTTGGTATTTGGAGGCTCCTGTGTCACTGCAGG
AACTAAAGGAGGCTAAATCCATGCCTGATGGAGGAGAAGAGTTCTATGGTTATCTGCAAATTCTGGCCAGACAACATCTTGACGTCACTC
CTTAGCTTCCATAACCTAGCCAAGCAAGAAGTTGCCTTTCCAAGACAAAGCAGTGTGCTCTAATGACTAACCCCTCAAAGTACTATGCCA
CTTTAACTATAGACCCATCTCCTCGATCAATCAGGATGGCAAGATGGAGCTGAGGAGCTCAGCAACATCAAGTCTGGAGTTGGTCTTTAA
CTCAACTAGCTCGTTTAGACGTGTCTGAACACCACATCACCTGACAGCACGGGGTGGTTTCCCAGTAAAATTTACAAACTCAGCTCAAGG
GCAGCTGTGTTGCTTTCCTTTCCTTGACTGCTGAGAAACTTTTTGACAGGGAACAATGGAAACACACCTTCTGAGCTGAAACAAACAAAC
AGAAACAAAACATACTAACCAGCAAAATCCCCAAATCATCAATCTTGGGTTCTCTTGAAGGGCAGGAGTGTGTTTTATCTTCTCCCGTCG
GAGCAAACACTATAGATGTCCTCCCTAAAATTCTGTCTTCCCTAGAGCAGCCTTGTAAATTAGCTAGGGTCCTAGGGTTGAGGCCTAAAT
CAACTTAAAATTGTCTCTAAATATGTACCTGGATGTGTTTGTACTTGCAGAGCATGCCCTCTTCATGTGCCTAGGGCTAGTAACTCCCTG
TGGCAGAGGCATGTAAAGTATTCTGACTTTTTTTTTTTCAACTTAATTCCATTTCCAATGAAATGGATTTTTAAAAATTTTCTCCAGAGT
GTGCCATACTTCTCCAGCTATTATAGTTAATGTGTGTGTATCCTTGTGTATATGTGTGTTTGTGTGTGCATATGTGTTTTCCTAGTGGTT
ACATGCTTACTAGGCAATTATGTAAATAAGCACAGATTCATAGGCCAGCTAGGCCTGAGGAAAGAAGACATTATAAAGGGAGGGAGTATT
TTAACATTAGCTAAAGCTATCACACAAGGCACCCATTCTGCTCCCCTCAACAGCCACAGCCCACTTCGTCCTTGTCTTACCAATAAGGGG
AAAGGCTGGAGGTGATATTTTTCACAGAACCGCAGAGGTTTTGAACATATTTGCAACATTACTTTGAGTACACATGAGCAAAAATTCTGA
ATTACATCCAGGACCCCAGAAGCTCATTAGATCAAAGAGTGCGGGGCCCCTCAGAGTTACCAGAGATTATCTGCAGACTTCAGTGCAATC
GAATGACCATGGTCCATTTTGATGGTCAGAGGTAGGACTGAAAAACGGGTAGAAACAATTGCTTTAGCGCTTCCTTCTGTACTTTGCCTA
TTAATGTTTTGTCTTTCAAAAATATATTTTCTCCTAATTGTTTAATTGGCCAAATAATGGCTGCTTTGGGAGTTGTTTGTATGCCTTGGA
AGGCCATGGCCTGCACTTTAAAAATAAGCTAAGTCCATTCTGCCCAGCACGAGCATTAGGACAGAGAATGCACTTATTTTAGGATCCTTA
AAAATTGCTTCTTTTATGGCACACTGGGTTGACGACTCATCTCGTGGGAGCCTTCATGGCACATTGCTGCTGTTCTGCAGGTCCCAATAC
AATTCCTTCCCCCTCTCAGTGCCACGGCCCCCCCATTGCTAGCTACAACAATTTGATATCATATTCCCTTTTCAACTCCAAAGGAGATGA
TAAGAAGCTATCAAATAATGCTTTAAAAAAGCAACTTGAGTTTCTTAAAAGAAAGGAAATGAATACATGCTGCATAATTACATTTAAAAT
GTAAGCCATGTTATTATAAGCCGCACTGAGATGAAGATTTGTTAGCAAACCAGTTTCAAGCACACTCACAGTGAAGTAAAATCATGTTTT
TAGCATCTGACCATTGGGTAATATTATTCTTTGTTATCAAAAGAGAAATATCACCCAAGTATAGTATACTTAGACCTCCTAGAGGAAACA
CTCCAGTCCTAAGCTTGGTGTCTGAAAAGAAAAACAAAAATAAAGATTATGGATTTAGGTCAGGGAGACAGAGTGATATTCTGAAGACTG
TGTTTACTCCCTCATCATCGGCCAACCAAGATGGAGTTCTGCATCCTGCACATATCAGACATTTCAGTCCAATTTCACCAAAGCATCAGT
GATGTTCTAGAAGCATCCCAGCAGATGGAGGATCCTAATGTATTTGTTCTGGGTATTTCCCAAGGCCCAGCCTGACTGGAGTGTGTGTAC
CAACAGGATGAATCCAATCAAGCTACGCCCCCATTTTGGTTTCGGATTGGCCACTCTTGCATGTGCTAGTAGATTGTGGACCAGGACCAG
CTGAGCAAACACAGTTGCAGAGTAGCCTCCTATGTTGCTAAGAAGCTCCTGCTACCCAGGTGCTTTGAACAATTGAGTGCTCCCTCTGGT
TAAGTAGAGATGGCACCACCGGAGTTTTTCTTGGATGTGAGGCTCAATCCTTTACGGCAGCTATTATAACAAAGTGAAGGTTTTCTCCCT
GGGAAATGCAGCTTTTCTCTGTCTTTACTAATTCTGCCAGCCTGTGAGAGTAACCACCGTAGCTGGGCTTCTTCTCAGATTAATTGTCAT
GCCAGGTCTCCTTCCTGGGGAGCTGTGATGCTGCTCTGAGGTTGATTGCTGAGGTTGTAGTGGGTTTTTGTTTGTTTTTGTTTAGTTTTT
CTTGATTGTTCTTCTTTCTCTTGAATGGCAAGAGAAGAAACACTTTCTCTAACCCACGGCCAGGAAGGAAATGGGGAGAGAGCTACTTCT
TAGTTCAACCTGGTTGCCACATAAAGGAATCTCTCTCCTTGGACTCAGCCCCTAACTGGAAGCAAGAGCCACTGCCCTCTGAGACTGAGA
GAGCAGCCCGAGGAGGAGATGAATCCATTCTGCCCTTTGTTTGGGTTTGCTTCCTGTCAGTGAGAGAATGCTGAGGCAGTTCCTGTTATG
TGAAACTTTCATTTTTAAAACCAGGACAGTCCTAAACAGACTGGAATGAGTTGGTCAATCCCAGTTGGTATAGGCCCAATGATTTTTGCT
AGTAAGATAGGATTGTCTTCCTCACCCAAAATGCCTTCAAGTGCCCTAAAATGGGTATTTTAAAATAAGAATAAATAATGTAGATTTAGT
AGAAAACCTGGAAAACATAAGAAACAAAGATGAAACGAAAAGTCCCATGTAATTCCACCAGTTAGAGTTAACCACTGATATCGTTTGGAT
ATATGGCTTTCTAGTCTTGTGGATATCCTTTTAATCTCTTGTAATATAAAGTCTGACCATATGTGTCCTTGCATTTGTTTGTACTGGACT
CTGTTAATATTTCTATAGTAATGGCTCACTTTGGGGAGATTGTGCTGCACAGTGTGTAGGAAGCACATTGGGTGTATTATTCCCAGTTTT
GTATTTTGTATTTCCTTGGAGATGTGCAGGGGTTAAGAGCGGGGGTCTGGCCATAGCTGGCCACGTCAGACTCTCATATGGTAAGTATCA
CAGAGCACATGAGGCCTGTGTTATGCGCTGGAAAGACTCAGGAAATGAGAGGCTCTCTTGTTCTGACAAGGCAGGCTGAGAGCTCTCATT
TAGGGTCATCACTCCAGATAACTCCAAATGCAGTTTATTGCTCAACTGAAGCAGATGATCACTTTTTGCCTCCAAGTTCTTCACCCTAGC
TAGCTCCTTTCAAAGAGCCGAGTATGCTGGATCTTAAAGGGCCAAACTAGTTACATCTCATACATTTCCTGATGTTTAGGGATGCCTTCA
CTTCCATCAAGGATACCTTGGCTGTGCAAGGACCTCTGATAGCTGGAGTCTCCTTTTGGTCACTCCCAGCTTTGCTTAAACTTGATGGAG
TTTGCTGTCCAGTGATCCCCGGATCTTTCATCATGAAAGCCTTCCTTCCTCTCCTGATGTCTCAGGCCTCTAGACCTAGACTGGGGTTCT
GGCAAGGAGGCCTCTATCAATAGTATGACATCCAATAATATGTTAGTGTTGATATTTTGCACAGTAATATTAAGTTTAAGAGATTATAAA
AATGAGTTCAAATGAATAAGTTCCTGTGATGTAAGAGATTAGATATGTGTGATTTCAGAACCAAAGGCAGGGGGGAATCCCAGAAAGAAA
ACAATAATATAATCCTAGTTTCTATATATTATTTTTATTCATTACTGTATATGGGTAGAGATCAATATTCTTTCTTATGCTGTTACTATT
AATTAACACATTTTTTAACCATGCCATTGAACTTTTGGGTGCATTAAAGTGGAACCCAAGCTCCTCATTAGATAATAATGGCATTTGGAC
TGAGTGCCATATTCCTAAATTTCCAATAAAGTGGTTGATATAGAGAGGACAGGATAAAGCCCTATAGTGTGCAGTTATATCAAAACAGCT
AGTCTCCACTTTAGGGAATGCCTTTACTAGAGATTACATGAAATGTCTGCTTATAAAATAAGCAGAGATGGCACCACTAAGCAGCCACCT
GAATTGTTTTCCTACAGGAATGATTACTTTTCAGATCCATTTATGTTTTCATGCTCAATACTTACTCCCCTTCCCTGCAACACCCAAAGA
GTTTACTTTTGCAAGTCATTTGGTCTTCAGTCTACTACTGAGGAATAGAGAGGCACTAACTGCTTTACCCAGGATCAGAACTCATGTTCT
TACCTTCTATTAATAGAGTACTTGAGCCAGATGGACTAACTGGTCTCACATTTTCTCTATCTTGGTTTTACTTCCATAAACATCAATATC
TTTACCCACATGATTTTTCCATCCTCCCATTTTTTTCCATATGTATTAGGGTTCAGGAACTATGATGCTAATGATCACATTTCTTCCTAG
TTCCTAATTTCATTAGTGCCATTTCCTGATATCTACAGAAACAATTATCAATACATGTAGCTGCTTGAGCCTTATTTAGAAGGCTAGCCT
TTCTTTTCCAAGTGCTGTCAGAATGTATACATTTAGTCTGTCTTTTTCCCTTTTAGGAGTCTTTGTTCTGGGTTGATGGCAAAATTCCTC
TTTTTACATGTGAGATTTTTGATTTCACTGAATTCTACCTAGATTTTTATGGACATTGGATTTTAAAGAGGAAAACACTCATTTTCTTAG
TAAGATATTGGTGATACATAGCTATGCCATTGATTTCCATACTCCTGAGCTTTGGGGAGGGAGACAGTGGCCAAGTAGCAGGCAGAATAA
GATCATCACTCATGTCCTGAATCAATCACACTTTCCTTCTCGGATTGTGTATATGCTCTGCCACTTCCTACATATTACATCCTGAGTTTT
TAAGTAAAGTGGATCTTAGCCAGATTTGAGTCTAATGGCTGATTCATCGGCATAGTTCTTGGCGTTAACATCTCAGTGTCCTCTTTAGTT
CTCTTTGAGGATTCATGTCATTGAGGGCCTTTGTGCCTCCACTTGTCTCAGTATGAGGAAGAACTTTGGTGTGAGGGCGGAGCTATGTGA
AGGGTTGCTGGGTTGGGGGATTAGTTCATATGGTCCCCATGCCATCTATTTACTTTTGGAGAGAGGGGACTTTGAGTGGGTGGGTATGGA
TAGATGTTCCTCAAGGAAACCCTGCTGGCTAATGGGCACTACATCTGTGTATTACTGTGATTCTCTCTGTAAGCTCCCCATGTGGCCAAG
GACCCCCCTCCTACCAGGGCACTTCCTGCCACCTCATTGCACTGGTCTCAACCATTCAGCCTGCTGCTGCTGCACCATGTTGGGCTGCGG
TAGGATAGGGAAGGGGTTCTGTTGATTGCTAAATGTTGCCTAACTTTATTTCCCTCTCCCACATTTCATGCAAGGGAGCGGACCTAACAC
ATGACTTGCATTCTCTTCCTATGTTCAGAAACTCCAGGGCTTGCCCACGTGTATGTATGAGTGACCAATGGAGCTTGGAATTCTTTATCT
ATATGATCTGTCCGAAAATGAGATCTTTTGTACTGGAATTTGTGATGTAGTTGATCATTCAGAGCCAAACGCATATACCAATAAAGACAA

>490_490_5_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376208_length(amino acids)=406AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP

--------------------------------------------------------------
>490_490_6_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376213_length(transcript)=4499nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGGCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCA
TCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAAC
AGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAA
GTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCA
CGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGAC
CCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAG
GGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCAC
TTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTG
TACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACG
ACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAG
GTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAG
CGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTA
GGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGC
CACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTCTTCATCCATA
GACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTT
CTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCTGCATAGACA
AAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGA
TGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCT
ATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATCTGTGAAGCCT
TTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGGGATCAGCTGG
TGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCTGAGGAGTAAA
AAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGA
CACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCGCTATCCACAG
AACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACTTGGAAAAGAT
AAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCCATGCCCACCC
GTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACGTCGTTTCCCT
GATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAATGTCTCTGCGT
TGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTGGGAAGGGCAG
AATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCTTGCTCTGGGC
TCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAAGTCAAAATAC
AAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTTTTGCAAAAAG
AGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAAGAAAACTTGC
TACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCATCTTAGGTCAT
GTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTATTTTTCATTA
AAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCAAGCGAGGGAG

>490_490_6_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376213_length(amino acids)=691AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP
SSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA
RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQH
FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNE

--------------------------------------------------------------
>490_490_7_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376214_length(transcript)=4547nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGATTTCTCATGGTTTGGATTTGGGAAAGTAAAATCAAGACAAGGTGTTGGCCCAGCCTCCGTTATCAGCAATGATGAT
GACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATG
ACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGA
CATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGAC
AAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTC
CAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTC
AACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCAT
ATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGG
GAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTG
CCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAG
ATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCC
CGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACC
CTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACT
CCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAA
GACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCT
TTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTT
CTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCC
AGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTT
TGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGC
TTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATT
ATGAACCGCAATATGGGAGGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGG
GAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATC
ACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTC
GTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCC
AGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGA
ACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTC
GATTAATACCTTGTGTGCAGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAAT
TAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGC
CTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATC
ACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGT
CAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACC
AAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGT
CAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTAT
AACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTT
AGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAAT
TAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGC

>490_490_7_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376214_length(amino acids)=707AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD
DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

--------------------------------------------------------------
>490_490_8_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000395866_length(transcript)=1795nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGGTTTTGTTTTGTTTCATAAGATCCCACTGGATGGGTAGCTGAAATAAAGGAAAAGACAGAGAAAGGGGCTGTGGTGC
TTGTTGGTTGATGCTGCCATGTAAGCTGGACTCCTGGGACTGCTGTTGGCTTATCCCGGGAAGTGCTGCTTATCTGGGGTTTTCTGGTAG
ATGTGGGCGGTGTTTGGAGGCTGTACTATATGAAGCCTGCATATACTGTGAGCTGTGATTGGGGAACACCAATGCAGAGGTAACTCTCAG
GCAGCTAAGCAGCACCTCAAGAAAACATGTTAAATTAATGCTTCTCTTCTTACAGTAGTTCAAATACAAAACTGAAATGAAATCCCATTG
GATTGTACTTCTCTTCTGAAAAGTGTGCTTTTTGACCCTACTGGACATTTATTGACTTAATTGCTTCTGTTTATTAAAATTGACCTGCAA

>490_490_8_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000395866_length(amino acids)=346AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG

--------------------------------------------------------------
>490_490_9_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000395882_length(transcript)=6438nt_BP=460nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGCA
GGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGG
ATAACTAACATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTC
ACTGTGCATTTTGCACCAACTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCC
AAACCAGCGCTTCAGTGGTTCTATAACGGGGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAG
TACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATGAACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAG
AAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTGCAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGA
ACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGACGTCACTGATAAAACCGGTCGGGAACATCTC
TCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTTAAGTTGGCAAGACACTCCAAG
TTTGGCATGAAAGGTTTTGTTTTGTTTCATAAGATCCCACTGGATGGGTAGCTGAAATAAAGGAAAAGACAGAGAAAGGGGCTGTGGTGC
TTGTTGGTTGATGCTGCCATGTAAGCTGGACTCCTGGGACTGCTGTTGGCTTATCCCGGGAAGTGCTGCTTATCTGGGGTTTTCTGGTAG
ATGTGGGCGGTGTTTGGAGGCTGTACTATATGAAGCCTGCATATACTGTGAGCTGTGATTGGGGAACACCAATGCAGAGGTAACTCTCAG
GCAGCTAAGCAGCACCTCAAGAAAACATGTTAAATTAATGCTTCTCTTCTTACAGTAGTTCAAATACAAAACTGAAATGAAATCCCATTG
GATTGTACTTCTCTTCTGAAAAGTGTGCTTTTTGACCCTACTGGACATTTATTGACTTAATTGCTTCTGTTTATTAAAATTGACCTGCAA
AGTTAAAAAAAAATTAAAGTTGAGAACAGGTATAAGTGCACACTGAATAGTCTAATCTACATGTAACACATATTTTAGTGTGATTTTCTA
TACTCTAATCAGCACTGAATTCAGAGGGTTTGACTTTTTCATCTATAACACAGTGACTAAAAGAGTTAAGGGTATATATACCATCACTTT
GGGACTTGGTAGTATTATTAAAAGGTTATTTCCTTCACTGTCAATAAAAGTCCAAATGTTTAGCTTAGGTCTGAGAGTCAAACAATGTTA
AGGATTGTCTTAAAGTTCCTTAGCCAGCAAAACAAAACAAAACAAAACAAACAAATGAAAAACGTTTAAAAAGAAGAAGAAGAAAAAAAA
CAAGAACAAGCAGCAACAGCTGTTTTGTTGGGGCTATAGATTTAAGTTAGGCATAGTCAATTTCAGAATAACTAAGAGTGGAATATATGC
ATATGGTGAAATTATAACCTTGCCCTTTTTTATTTGCCCTCTGCGATCCACCTGCTTTTTAGAAGTCTGCCGAGTGAGAAGGCCACAGTA
TCTCATGCTGTTTGCATTACAGAACTGCAGCTTTTCTACTCTGAAAAGGCCTGGGAGCAGAATGGCTGGCCTGCTGTGAGCAGGAGAGGA
GATTCTAAGAAGGATAGTCCCCCCTACAACATACTGTCATACTGCTGGGTTTTCATGGGTAGGAAAGCTTGTCCTGACCCCAGCAGCAAA
GAGGTGGCAGGTCGCTAATGAATATATGCTTTATAATGTCCTTCTTCATTGCTGAGAGGGCAGCCTTAGAGCTGTGGATTTCTGCATCCC
CCCTGAGTCTGACCCATGGACACCTGTTTCATTCACTTTAGCATCACAGTGACCTTTGTATGCTCTGTTCAGTCTGTGTCAGGCAGTATG
CTTGTCCTGAAGAGAGGTTTGGCTATCCCCACCCCACCCCACCCCACCCTGTTCCTTTTTTATCAGGAGGACTTCAGAGCCAGGCCTGCA
GCATTTTGTTTGAAAACACAATCAGCTCTGACAGTTAGACATGCACACAGACGCCATAGCTGGATTGGAAACATTGATGTTTTAAAAATT
TATTTTTTTTGGAAATAGTTGCACAAATGCTGCAATTTAGCTTTAAGGTTCTATAGATTTTTAACTAGTCCAACACAGTCAGAAACATTG
TTTTGAATCCTCTGTAAACCAAGGCATTAATCTTAATAAACCAGGATCCATTTAGGTACCACTTGATATAAAAAGGATATCCATAATGAA
TATTTTATACTGCATCCTTTACATTAGCCACTAAATACGTTATTGCTTGATGAAGACCTTTCACAGAATCCTATGGATTGCAGCATTTCA
CTTGGCTACTTCATACCCATGCCTTAAAGAGGGGCAGTTTCTCAAAAGCAGAAACATGCCGCCAGTTCTCAAGTTTTCCTCCTAACTCCA
TTTGAATGTAAGGGCAGCTGGCCCCCAATGTGGGGAGGTCCGAACATTTTCTGAATTCCCATTTTCTTGTTCGCGGCTAAATGACAGTTT
CTGTCATTACTTAGATTCCGATCTTTCCCAAAGGTGTTGATTTACAAAGAGGCCAGCTAATAGCAGAAATCATGACCCTGAAAGAGAGAT
GAAATTCAAGCTGTGAGCCAGGCAGGAGCTCAGTATGGCAAAGGTTCTTGAGAATCAGCCATTTGGTACAAAAAAGATTTTTAAAGCTTT
TATGTTATACCATGGAGCCATAGAAAGGCTATGGATTGTTTAAGAACTATTTTAAAGTGTTCCAGACCCAAAAAGGAAAAATAAAAAAAA
AGGAATATTTGTACCCAACAGCTAGAAGGATTGCAAGGTAGATTTTTGTTTTAAAATGGAGAGAAGTGGACAGATAAGGCCATTTAATAT
ATCAAAGATCAGTTGACATCTCCTAGGGAATGATGAAAACAGCAGGCTATTAGAAAATTATTTCATATAGTTCTCGTGTTCTTTTCTTTT
TTTTAATCCCTGAAGGGATGATCAGTAACATAGCTTCTCTTTTCTGTACTCTAGACCACCCCTTTTCATCATTTTGCTTTTTATGTCTCC
CATAAGAAATGTGCTTTTTAGAGCTTCCTAATGCATGTGTTGCATTATTGCAGCATTAGAAAAGGAGAGGTAGCATTTTTGCTGAAATCG
GGCCTGTCACTCTCCAATAAAGGTTCTGGCACTTCAATGCCAGGCAGGTCTCCTAAATGAACAGAATGATCTGTGTGAGCCGATGCCTGC
CCTTCCAGAGGGGCCACTGTCCCCAGCCGCAGCCAACTGTGTCCCACAGGAATGGGAGCCTAGGTTTCCAAATCTTGTGATTCTTTAGGA
GAAACATGAAACCTGGATTTCGTGTGAAATGTCCCGATTGTTAAAAAGTTGGCTCAATTATTTTTAAAACATTTTGTAAGCCAACAAAAG
TCTGTGGGCTGCCAGTTTATTACTTTTGTCTTAAAACATGATCATTGTTCTCTCACGGTATCCTTCTGTCTTCCCGTTGCAAATTCACTT
TTCTTTCTTCCTGACATTGCCATTGAGGGCTTTGTTACCACAAGCTAAGAAACTGAGTTTAACAGCCCAGTTATCTGCAACATGTCAATT
ACCTTTGCTCCTCTCCTGTGATTCCCACCATGCTGTGACCCTCAGCTGTCTCCCTTTGCTGGGAATTCTGCACCAATGTCTCCCCTCAAC
CCATTCCCTGGTTGGTCCTACTCCCGTGTGGCCAGAGACATCCTAGCAAATCCTTCCTCCTATTATATCTGACACTAATTTCTTTTCAAC
AGCGCTCATGTCTCTTGGCCCAGTCAGGTGCTGCCAGGTTTAGATAGGAAAGTACATGTCCCATTTTCATGGGTGCCCTTAATGTGGTCC
ACGTCCTATATCTTATTATATTTACTCATGGCTCAATGGGGGCCTCCAGAGACCCTCTCAGGCTGCTGAGCTAGACTAAGGAATGCATCC
ACCGTCATCACATGAGACACTGACTCTGTGACGACAAAAGTACAAACAGTCTGAGGCTAAGAAAGGTTCATCTCACAACAGGAAAAACAA
ATCTCAACACACATTAGAGATAATTGATTCAGGGGTTTTCTCTCCCAGTCTCCCAGCAGGGACTGATTTCATTTCTGACCCACTAGGTTT
TCTTTCCAGAAATAGGTAGCAAGGACAAGAACTAAACAATCCCAGCCCCACCCAGCAACACAGAACACAGGAGTTTGCTTTTGGCTTCTC
ACTCTCCAAGTAACCCTGAATTAGGCCCAGAATGGCTGAGGCTTGGAGCATCTCCTCAGACAGAGCAGAGGCGACACCTCTTCAGGGGTG
TGTGGAGTAAATAGCTCGAAGAGCTGAAGACAGAAAACCAGTTTCACGCCAGGTGCGAGAGAGAGCATAATGGAGGGAAGCCCGCTTTCT
CTCTCCTCTTCTTTTCTCTTTATTTCTTTAGAGCACTTGACTTTTTTTTCTCTCTCTCTCTAGTATTCTAAACTGACCCCATGACCAACT
GAGAATTTATTTTTGTTTCATTGGTTGTTTCACAGAATTAGAACACACACGACTTTTTATTCCTCCATTGCAAAATGGAATCAAGATACT
ACACAAGACCTGTGCTTTCTTCCTTTGCATGATTTACACCTCCGCCTGTTTTGGTGCTAGCTGTCTAGAACTTCTCTCTTGGTTTGAATC
TGATTCCTTCACACTACACTAGAAGTTTATTTCATCTTGTTTTGTCTAGACTCCAGATACAGAGGGACAGCTGGACTGAGGACAAGCAAT
TCCATCTAGCATAGGGTCTCTCAGGGTTGGTGCATCCAGCCACATGGGCAGGGCCAGTCACATCTAGTCTATGTCCCCAGAGCCCTTGGA
GTTGCGCAGCTTAGCTGACTTGACTCCAAGGAAATTAGTACAGAAGTAACCACTCTATTAAGTGTGTTCTGCTATGTTCACATGCCTGTA
GTACCTGCAAACCATGCCAGGTTCATCTAAAGACATAGGGGAAGATTAAGGACTCTTTTGGACAGACCATGAATTGAATTTGCTGCCAGG
TGCTGCCAGACTGAATTTGGCTGACAGAACTCCCAGCCCAGGAAAGTTCCATGACAATGACTGTCGCAGAAGGAAATTTCCCACTAAAGT
CAGTCCATTTTCAAGTTTTGGTCTTCAGAGACAAAAGAACGTCCCAGCCACCTGATTTTGATGGTGAGGTAACTCTAAGTTGAATTCAGG
CTAGTGTTGCAGTATAGCTTTGGCATGTTCATGAGTGAGCACCCAGAATGTGTTGAACCAACCCCCACCCCTAACTACTGACTATGACTG
CAGTGGGTTTTTATGGGGAAAAAAAGTGTGAAAAGCAAAAAGAAAGGAACAGAGATTTTTTATCACCTTTATTGTAAGACAGTCCATTTA
TGAATTGAGTATAAACACATACAAAGTAACAAGAGATTCCTAAGAAACGCAAATCCTTGAGTTTCACGCACTTCATGTTCAACCATTTGC
TGTAATCCAGAGGCAGCCTGTGAATCATTCTCATGCCCTGTTTTTTTTTTTTTTTTCCTATAATGTTCTGGGTTTAAAAGCCATCTTTTC
CACATTTTCTGTAAATAATGGATAATCATTTTAAAAATTTTTATTTTTAGTGCTGTTTTAACAATGTAGATAGATCATAAATGTACTTGC

>490_490_9_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000395882_length(amino acids)=346AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG

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Fusion Gene PPI Analysis for ABL1-NTRK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519455_466194.33333333333334839.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515455_466194.33333333333334554.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417455_466194.33333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412455_466194.33333333333334478.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514455_466194.33333333333334538.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720455_466194.33333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721455_466194.33333333333334839.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412455_46638.333333333333336322.0MAPK8IP3/JIP3
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513455_466194.33333333333334478.0MAPK8IP3/JIP3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABL1-NTRK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABL1-NTRK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource