FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LONP1-CARD8 (FusionGDB2 ID:49410)

Fusion Gene Summary for LONP1-CARD8

check button Fusion gene summary
Fusion gene informationFusion gene name: LONP1-CARD8
Fusion gene ID: 49410
HgeneTgene
Gene symbol

LONP1

CARD8

Gene ID

9361

22900

Gene namelon peptidase 1, mitochondrialcaspase recruitment domain family member 8
SynonymsCODASS|LON|LONP|LonHS|PIM1|PRSS15|hLONCARDINAL|DACAR|DAKAR|NDPP|NDPP1|TUCAN
Cytomap

19p13.3

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionlon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15caspase recruitment domain-containing protein 8CARD inhibitor of NF-kappaB-activating ligandsapoptotic protein NDPP1tumor up-regulated CARD-containing antagonist of CASP9tumor up-regulated CARD-containing antagonist of caspase nine
Modification date2020031320200320
UniProtAcc

P36776

Q9Y2G2

Ensembl transtripts involved in fusion geneENST00000360614, ENST00000585374, 
ENST00000590729, ENST00000593119, 
ENST00000590511, ENST00000540670, 
ENST00000357778, ENST00000359009, 
ENST00000391898, ENST00000447740, 
ENST00000519332, ENST00000520007, 
ENST00000520015, ENST00000520153, 
ENST00000522431, ENST00000600800, 
ENST00000519940, ENST00000520753, 
ENST00000521613, 
Fusion gene scores* DoF score18 X 14 X 12=30246 X 5 X 4=120
# samples 236
** MAII scorelog2(23/3024*10)=-3.7167523732767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LONP1 [Title/Abstract] AND CARD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLONP1(5719715)-CARD8(48718641), # samples:2
Anticipated loss of major functional domain due to fusion event.LONP1-CARD8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLONP1

GO:0034599

cellular response to oxidative stress

17420247

HgeneLONP1

GO:0051603

proteolysis involved in cellular protein catabolic process

8248235|17420247

TgeneCARD8

GO:0031665

negative regulation of lipopolysaccharide-mediated signaling pathway

11821383

TgeneCARD8

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

11551959

TgeneCARD8

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

11821383|15030775

TgeneCARD8

GO:0050713

negative regulation of interleukin-1 beta secretion

11821383

TgeneCARD8

GO:0050718

positive regulation of interleukin-1 beta secretion

15030775

TgeneCARD8

GO:0097340

inhibition of cysteine-type endopeptidase activity

11821383


check buttonFusion gene breakpoints across LONP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CARD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3CC-06ALONP1chr19

5719715

-CARD8chr19

48718641

-


Top

Fusion Gene ORF analysis for LONP1-CARD8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360614ENST00000357778LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000359009LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000391898LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000447740LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000519332LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000520007LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000520015LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000520153LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000522431LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000360614ENST00000600800LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000357778LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000359009LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000391898LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000447740LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000519332LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000520007LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000520015LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000520153LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000522431LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000585374ENST00000600800LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000357778LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000359009LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000391898LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000447740LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000519332LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000520007LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000520015LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000520153LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000522431LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000590729ENST00000600800LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000357778LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000359009LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000391898LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000447740LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000519332LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000520007LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000520015LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000520153LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000522431LONP1chr19

5719715

-CARD8chr19

48718641

-
5CDS-intronENST00000593119ENST00000600800LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-3CDSENST00000590511ENST00000519940LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-3CDSENST00000590511ENST00000520753LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-3CDSENST00000590511ENST00000521613LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000357778LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000359009LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000391898LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000447740LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000519332LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000520007LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000520015LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000520153LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000522431LONP1chr19

5719715

-CARD8chr19

48718641

-
5UTR-intronENST00000590511ENST00000600800LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000360614ENST00000519940LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000360614ENST00000520753LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000360614ENST00000521613LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000590729ENST00000519940LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000590729ENST00000520753LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000590729ENST00000521613LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000593119ENST00000519940LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000593119ENST00000520753LONP1chr19

5719715

-CARD8chr19

48718641

-
Frame-shiftENST00000593119ENST00000521613LONP1chr19

5719715

-CARD8chr19

48718641

-
In-frameENST00000585374ENST00000519940LONP1chr19

5719715

-CARD8chr19

48718641

-
In-frameENST00000585374ENST00000520753LONP1chr19

5719715

-CARD8chr19

48718641

-
In-frameENST00000585374ENST00000521613LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-3CDSENST00000540670ENST00000519940LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-3CDSENST00000540670ENST00000520753LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-3CDSENST00000540670ENST00000521613LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000357778LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000359009LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000391898LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000447740LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000519332LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000520007LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000520015LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000520153LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000522431LONP1chr19

5719715

-CARD8chr19

48718641

-
intron-intronENST00000540670ENST00000600800LONP1chr19

5719715

-CARD8chr19

48718641

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585374LONP1chr195719715-ENST00000520753CARD8chr1948718641-176823414544176
ENST00000585374LONP1chr195719715-ENST00000521613CARD8chr1948718641-68923414544176
ENST00000585374LONP1chr195719715-ENST00000519940CARD8chr1948718641-63823414544176

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585374ENST00000520753LONP1chr195719715-CARD8chr1948718641-0.00083850.9991615
ENST00000585374ENST00000521613LONP1chr195719715-CARD8chr1948718641-0.0059484520.9940515
ENST00000585374ENST00000519940LONP1chr195719715-CARD8chr1948718641-0.0070553960.99294466

Top

Fusion Genomic Features for LONP1-CARD8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LONP1-CARD8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5719715/chr19:48718641)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LONP1

P36776

CARD8

Q9Y2G2

FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:8248235}.FUNCTION: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCARD8chr19:5719715chr19:48718641ENST00000359009710340_430328432.0DomainCARD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP1chr19:5719715chr19:48718641ENST00000360614-118124_368143960.0DomainLon N-terminal
HgeneLONP1chr19:5719715chr19:48718641ENST00000360614-118759_949143960.0DomainLon proteolytic
HgeneLONP1chr19:5719715chr19:48718641ENST00000360614-118523_530143960.0Nucleotide bindingATP
TgeneCARD8chr19:5719715chr19:48718641ENST0000035900971056_340328432.0DomainFIIND
TgeneCARD8chr19:5719715chr19:48718641ENST00000391898811340_430434538.0DomainCARD
TgeneCARD8chr19:5719715chr19:48718641ENST0000039189881156_340434538.0DomainFIIND
TgeneCARD8chr19:5719715chr19:48718641ENST00000447740811340_430384488.0DomainCARD
TgeneCARD8chr19:5719715chr19:48718641ENST0000044774081156_340384488.0DomainFIIND
TgeneCARD8chr19:5719715chr19:48718641ENST000005199401114340_430434538.0DomainCARD
TgeneCARD8chr19:5719715chr19:48718641ENST00000519940111456_340434538.0DomainFIIND
TgeneCARD8chr19:5719715chr19:48718641ENST00000520015811340_430387546.0DomainCARD
TgeneCARD8chr19:5719715chr19:48718641ENST0000052001581156_340387546.0DomainFIIND
TgeneCARD8chr19:5719715chr19:48718641ENST00000520153912340_430384488.0DomainCARD
TgeneCARD8chr19:5719715chr19:48718641ENST0000052015391256_340384488.0DomainFIIND
TgeneCARD8chr19:5719715chr19:48718641ENST000005207531013340_430387840.3333333333334DomainCARD
TgeneCARD8chr19:5719715chr19:48718641ENST00000520753101356_340387840.3333333333334DomainFIIND
TgeneCARD8chr19:5719715chr19:48718641ENST00000521613912340_430384488.0DomainCARD
TgeneCARD8chr19:5719715chr19:48718641ENST0000052161391256_340384488.0DomainFIIND


Top

Fusion Gene Sequence for LONP1-CARD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49410_49410_1_LONP1-CARD8_LONP1_chr19_5719715_ENST00000585374_CARD8_chr19_48718641_ENST00000519940_length(transcript)=638nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGTGGATCTCCAGCTTGTAGCTGCATCAGCCCCTCCTC
CTTTCTCAGGTGCAGCCTTTGTGAAGGAGAACCACCGGCAACTCCAAGCCAGGATGGGGGACCTGAAAGGGGTGCTCGATGATCTCCAAG
ACAATGAGGTTCTTACTGAGAATGAGAAGGAGCTGGTGGAGCAGGAAAAGACACGGCAGAGCAAGAATGAGGCCTTGCTGAGCATGGTGG
AGAAGAAAGGGGACCTGGCCCTGGACGTGCTCTTCAGAAGCATTAGTGAAAGGGACCCTTACCTCGTGTCCTATCTTAGACAGCAGAATT
TGTAAAATGAGTCAGTTAGGTAGTCTGGAAGAGAGAATCCAGCGTTCTCATTGGAAATGGATAAACAGAAATGTGATCATTGATTTCAGT

>49410_49410_1_LONP1-CARD8_LONP1_chr19_5719715_ENST00000585374_CARD8_chr19_48718641_ENST00000519940_length(amino acids)=176AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRVDLQLVAASAPPPFSGA

--------------------------------------------------------------
>49410_49410_2_LONP1-CARD8_LONP1_chr19_5719715_ENST00000585374_CARD8_chr19_48718641_ENST00000520753_length(transcript)=1768nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGTGGATCTCCAGCTTGTAGCTGCATCAGCCCCTCCTC
CTTTCTCAGGTGCAGCCTTTGTGAAGGAGAACCACCGGCAACTCCAAGCCAGGATGGGGGACCTGAAAGGGGTGCTCGATGATCTCCAAG
ACAATGAGGTTCTTACTGAGAATGAGAAGGAGCTGGTGGAGCAGGAAAAGACACGGCAGAGCAAGAATGAGGCCTTGCTGAGCATGGTGG
AGAAGAAAGGGGACCTGGCCCTGGACGTGCTCTTCAGAAGCATTAGTGAAAGGGACCCTTACCTCGTGTCCTATCTTAGACAGCAGAATT
TGTAAAATGAGTCAGTTAGGTAGTCTGGAAGAGAGAATCCAGCGTTCTCATTGGAAATGGATAAACAGAAATGTGATCATTGATTTCAGT
GTTCAAGACAGAAGAAGACTGGGTAACATCTATCACACAGGCTTTCAGGACAGACTTGTAACCTGGCATGTACCTATTGACTGTATCCTC
ATGCATTTTCCTCAAGAATGTCTGAAGAAGGTAGTAATATTCCTTTTAAATTTTTTCCAACCATTGCTTGATATATCACTATTTTATCCA
TTGACATGATTCTTGAAGACCCAGGATAAAGGACATCCGGATAGGTGTGTTTATGAAGGATGGGGCCTGGAAAGGCAACTTTTCCTGATT
AATGTGAAAAATAATTCCTATGGACACTCCGTTTGAAGTATCACCTTCTCATAACTAAAAGCAGAAAAGCTAACAAAAGCTTCTCAGCTG
AGGACACTCAAGGCATACATGATGACAGTCTTTTTTTTTTTTGTATGTTAGGACTTTAACACTTTATCTATGGCTACTGTTATTAGAACA
ATGTAAATGTATTTGCTGAAAGAGAGCACAAAAATGGGAGAAAATGCAAACATGAGCAGAAAATATTTTCCCACTGGTGTGTAGCCTGCT
ACAAGGAGTTGTTGGGTTAAATGTTCATGGTCAACTCCAAGGAATACTGAGATGAAATGTGGTAAATCAACTCCACAGAACCACCAAAAA
GAAAATGAGGGTAATTCAGCTTATTCTGAGACAGACATTCCTGGCAATGTACCATACAAAAAATAAGCCAACTCTGACATTTGGATTCTA
CCATAGACTCTGTCATTTTGTAGCCATTTCAGCTGTCTTTTGATTAATGTTTTCGTGGCACACATATTTCCATCCTTTTATGTTTAATCT
GTTTAAAACAAGTTCCTAGTAGACACCATCTGGTTGAGTCAGTTTTTTTTATGGTGTATTTTGAACCCATTCTGATAGTCTCTTTTAACT
GGAAGATTTCAATTACTTACGTTAATGTAATTATTAATATGTTAGGATTTATCCTCAGTCAGCCAGTTTGTTATGTCTTTTCTATTCTAC
TGTTATCACATTTGTACCACTTAAAGTGGAATCTAGGCACTTTATCACCATTTAGATCCTATTACCTTTTCTCATCTAGGATATAGTTAT

>49410_49410_2_LONP1-CARD8_LONP1_chr19_5719715_ENST00000585374_CARD8_chr19_48718641_ENST00000520753_length(amino acids)=176AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRVDLQLVAASAPPPFSGA

--------------------------------------------------------------
>49410_49410_3_LONP1-CARD8_LONP1_chr19_5719715_ENST00000585374_CARD8_chr19_48718641_ENST00000521613_length(transcript)=689nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGTGGATCTCCAGCTTGTAGCTGCATCAGCCCCTCCTC
CTTTCTCAGGTGCAGCCTTTGTGAAGGAGAACCACCGGCAACTCCAAGCCAGGATGGGGGACCTGAAAGGGGTGCTCGATGATCTCCAAG
ACAATGAGGTTCTTACTGAGAATGAGAAGGAGCTGGTGGAGCAGGAAAAGACACGGCAGAGCAAGAATGAGGCCTTGCTGAGCATGGTGG
AGAAGAAAGGGGACCTGGCCCTGGACGTGCTCTTCAGAAGCATTAGTGAAAGGGACCCTTACCTCGTGTCCTATCTTAGACAGCAGAATT
TGTAAAATGAGTCAGTTAGGTAGTCTGGAAGAGAGAATCCAGCGTTCTCATTGGAAATGGATAAACAGAAATGTGATCATTGATTTCAGT

>49410_49410_3_LONP1-CARD8_LONP1_chr19_5719715_ENST00000585374_CARD8_chr19_48718641_ENST00000521613_length(amino acids)=176AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRVDLQLVAASAPPPFSGA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LONP1-CARD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LONP1-CARD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LONP1-CARD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource