FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LONP1-MAP2K7 (FusionGDB2 ID:49422)

Fusion Gene Summary for LONP1-MAP2K7

check button Fusion gene summary
Fusion gene informationFusion gene name: LONP1-MAP2K7
Fusion gene ID: 49422
HgeneTgene
Gene symbol

LONP1

MAP2K7

Gene ID

9361

5609

Gene namelon peptidase 1, mitochondrialmitogen-activated protein kinase kinase 7
SynonymsCODASS|LON|LONP|LonHS|PIM1|PRSS15|hLONJNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4
Cytomap

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionlon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15dual specificity mitogen-activated protein kinase kinase 7JNK-activating kinase 2MAP kinase kinase 7MAPK/ERK kinase 7SAPK kinase 4c-Jun N-terminal kinase kinase 2stress-activated protein kinase kinase 4
Modification date2020031320200313
UniProtAcc

P36776

O14733

Ensembl transtripts involved in fusion geneENST00000590511, ENST00000360614, 
ENST00000590729, ENST00000593119, 
ENST00000585374, ENST00000540670, 
ENST00000397979, ENST00000397981, 
ENST00000397983, ENST00000545011, 
Fusion gene scores* DoF score18 X 14 X 12=30242 X 4 X 2=16
# samples 234
** MAII scorelog2(23/3024*10)=-3.7167523732767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LONP1 [Title/Abstract] AND MAP2K7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLONP1(5719715)-MAP2K7(7974640), # samples:3
Anticipated loss of major functional domain due to fusion event.LONP1-MAP2K7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LONP1-MAP2K7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LONP1-MAP2K7 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLONP1

GO:0034599

cellular response to oxidative stress

17420247

HgeneLONP1

GO:0051603

proteolysis involved in cellular protein catabolic process

8248235|17420247

TgeneMAP2K7

GO:0006970

response to osmotic stress

9535930

TgeneMAP2K7

GO:0009408

response to heat

9535930

TgeneMAP2K7

GO:0009411

response to UV

9535930

TgeneMAP2K7

GO:0034612

response to tumor necrosis factor

9535930

TgeneMAP2K7

GO:0051403

stress-activated MAPK cascade

9535930


check buttonFusion gene breakpoints across LONP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP2K7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12L-01ALONP1chr19

5719715

-MAP2K7chr19

7974640

+
ChimerDB4BRCATCGA-C8-A12LLONP1chr19

5719714

-MAP2K7chr19

7974639

+


Top

Fusion Gene ORF analysis for LONP1-MAP2K7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000590511ENST00000397979LONP1chr19

5719715

-MAP2K7chr19

7974640

+
5UTR-3CDSENST00000590511ENST00000397979LONP1chr19

5719714

-MAP2K7chr19

7974639

+
5UTR-3CDSENST00000590511ENST00000397981LONP1chr19

5719715

-MAP2K7chr19

7974640

+
5UTR-3CDSENST00000590511ENST00000397981LONP1chr19

5719714

-MAP2K7chr19

7974639

+
5UTR-3CDSENST00000590511ENST00000397983LONP1chr19

5719715

-MAP2K7chr19

7974640

+
5UTR-3CDSENST00000590511ENST00000397983LONP1chr19

5719714

-MAP2K7chr19

7974639

+
5UTR-3CDSENST00000590511ENST00000545011LONP1chr19

5719715

-MAP2K7chr19

7974640

+
5UTR-3CDSENST00000590511ENST00000545011LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000360614ENST00000397979LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000360614ENST00000397979LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000360614ENST00000397981LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000360614ENST00000397981LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000360614ENST00000397983LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000360614ENST00000397983LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000360614ENST00000545011LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000360614ENST00000545011LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000590729ENST00000397979LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000590729ENST00000397979LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000590729ENST00000397981LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000590729ENST00000397981LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000590729ENST00000397983LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000590729ENST00000397983LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000590729ENST00000545011LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000590729ENST00000545011LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000593119ENST00000397979LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000593119ENST00000397979LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000593119ENST00000397981LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000593119ENST00000397981LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000593119ENST00000397983LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000593119ENST00000397983LONP1chr19

5719714

-MAP2K7chr19

7974639

+
Frame-shiftENST00000593119ENST00000545011LONP1chr19

5719715

-MAP2K7chr19

7974640

+
Frame-shiftENST00000593119ENST00000545011LONP1chr19

5719714

-MAP2K7chr19

7974639

+
In-frameENST00000585374ENST00000397979LONP1chr19

5719715

-MAP2K7chr19

7974640

+
In-frameENST00000585374ENST00000397979LONP1chr19

5719714

-MAP2K7chr19

7974639

+
In-frameENST00000585374ENST00000397981LONP1chr19

5719715

-MAP2K7chr19

7974640

+
In-frameENST00000585374ENST00000397981LONP1chr19

5719714

-MAP2K7chr19

7974639

+
In-frameENST00000585374ENST00000397983LONP1chr19

5719715

-MAP2K7chr19

7974640

+
In-frameENST00000585374ENST00000397983LONP1chr19

5719714

-MAP2K7chr19

7974639

+
In-frameENST00000585374ENST00000545011LONP1chr19

5719715

-MAP2K7chr19

7974640

+
In-frameENST00000585374ENST00000545011LONP1chr19

5719714

-MAP2K7chr19

7974639

+
intron-3CDSENST00000540670ENST00000397979LONP1chr19

5719715

-MAP2K7chr19

7974640

+
intron-3CDSENST00000540670ENST00000397979LONP1chr19

5719714

-MAP2K7chr19

7974639

+
intron-3CDSENST00000540670ENST00000397981LONP1chr19

5719715

-MAP2K7chr19

7974640

+
intron-3CDSENST00000540670ENST00000397981LONP1chr19

5719714

-MAP2K7chr19

7974639

+
intron-3CDSENST00000540670ENST00000397983LONP1chr19

5719715

-MAP2K7chr19

7974640

+
intron-3CDSENST00000540670ENST00000397983LONP1chr19

5719714

-MAP2K7chr19

7974639

+
intron-3CDSENST00000540670ENST00000545011LONP1chr19

5719715

-MAP2K7chr19

7974640

+
intron-3CDSENST00000540670ENST00000545011LONP1chr19

5719714

-MAP2K7chr19

7974639

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585374LONP1chr195719715-ENST00000397981MAP2K7chr197974640+3438234141390458
ENST00000585374LONP1chr195719715-ENST00000545011MAP2K7chr197974640+3542234141495493
ENST00000585374LONP1chr195719715-ENST00000397983MAP2K7chr197974640+3398234141369451
ENST00000585374LONP1chr195719715-ENST00000397979MAP2K7chr197974640+3417234141369451
ENST00000585374LONP1chr195719714-ENST00000397981MAP2K7chr197974639+3438234141390458
ENST00000585374LONP1chr195719714-ENST00000545011MAP2K7chr197974639+3542234141495493
ENST00000585374LONP1chr195719714-ENST00000397983MAP2K7chr197974639+3398234141369451
ENST00000585374LONP1chr195719714-ENST00000397979MAP2K7chr197974639+3417234141369451

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585374ENST00000397981LONP1chr195719715-MAP2K7chr197974640+0.0108103320.9891896
ENST00000585374ENST00000545011LONP1chr195719715-MAP2K7chr197974640+0.0242541450.97574586
ENST00000585374ENST00000397983LONP1chr195719715-MAP2K7chr197974640+0.008118970.9918811
ENST00000585374ENST00000397979LONP1chr195719715-MAP2K7chr197974640+0.0079787650.99202126
ENST00000585374ENST00000397981LONP1chr195719714-MAP2K7chr197974639+0.0108103320.9891896
ENST00000585374ENST00000545011LONP1chr195719714-MAP2K7chr197974639+0.0242541450.97574586
ENST00000585374ENST00000397983LONP1chr195719714-MAP2K7chr197974639+0.008118970.9918811
ENST00000585374ENST00000397979LONP1chr195719714-MAP2K7chr197974639+0.0079787650.99202126

Top

Fusion Genomic Features for LONP1-MAP2K7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LONP1chr195719714-MAP2K7chr197974639+1.97E-091
LONP1chr195719714-MAP2K7chr197974639+1.97E-091
LONP1chr195719714-MAP2K7chr197974639+1.97E-091
LONP1chr195719714-MAP2K7chr197974639+1.97E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LONP1-MAP2K7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5719715/chr19:7974640)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LONP1

P36776

MAP2K7

O14733

FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:8248235}.FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397979011120_38041420.0DomainProtein kinase
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397981011120_38041427.0DomainProtein kinase
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397983112120_38057436.0DomainProtein kinase
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397979011120_38041420.0DomainProtein kinase
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397981011120_38041427.0DomainProtein kinase
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397983112120_38057436.0DomainProtein kinase
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397979011126_13441420.0Nucleotide bindingATP
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397981011126_13441427.0Nucleotide bindingATP
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397983112126_13457436.0Nucleotide bindingATP
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397979011126_13441420.0Nucleotide bindingATP
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397981011126_13441427.0Nucleotide bindingATP
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397983112126_13457436.0Nucleotide bindingATP
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397979011377_40041420.0RegionNote=DVD domain
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397981011377_40041427.0RegionNote=DVD domain
TgeneMAP2K7chr19:5719714chr19:7974639ENST00000397983112377_40057436.0RegionNote=DVD domain
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397979011377_40041420.0RegionNote=DVD domain
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397981011377_40041427.0RegionNote=DVD domain
TgeneMAP2K7chr19:5719715chr19:7974640ENST00000397983112377_40057436.0RegionNote=DVD domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP1chr19:5719714chr19:7974639ENST00000360614-118124_368143960.0DomainLon N-terminal
HgeneLONP1chr19:5719714chr19:7974639ENST00000360614-118759_949143960.0DomainLon proteolytic
HgeneLONP1chr19:5719715chr19:7974640ENST00000360614-118124_368143960.0DomainLon N-terminal
HgeneLONP1chr19:5719715chr19:7974640ENST00000360614-118759_949143960.0DomainLon proteolytic
HgeneLONP1chr19:5719714chr19:7974639ENST00000360614-118523_530143960.0Nucleotide bindingATP
HgeneLONP1chr19:5719715chr19:7974640ENST00000360614-118523_530143960.0Nucleotide bindingATP
TgeneMAP2K7chr19:5719714chr19:7974639ENST000003979790112_3041420.0Coiled coilOntology_term=ECO:0000255
TgeneMAP2K7chr19:5719714chr19:7974639ENST000003979810112_3041427.0Coiled coilOntology_term=ECO:0000255
TgeneMAP2K7chr19:5719714chr19:7974639ENST000003979831122_3057436.0Coiled coilOntology_term=ECO:0000255
TgeneMAP2K7chr19:5719715chr19:7974640ENST000003979790112_3041420.0Coiled coilOntology_term=ECO:0000255
TgeneMAP2K7chr19:5719715chr19:7974640ENST000003979810112_3041427.0Coiled coilOntology_term=ECO:0000255
TgeneMAP2K7chr19:5719715chr19:7974640ENST000003979831122_3057436.0Coiled coilOntology_term=ECO:0000255
TgeneMAP2K7chr19:5719714chr19:7974639ENST0000039797901137_5741420.0RegionD domain
TgeneMAP2K7chr19:5719714chr19:7974639ENST0000039798101137_5741427.0RegionD domain
TgeneMAP2K7chr19:5719714chr19:7974639ENST0000039798311237_5757436.0RegionD domain
TgeneMAP2K7chr19:5719715chr19:7974640ENST0000039797901137_5741420.0RegionD domain
TgeneMAP2K7chr19:5719715chr19:7974640ENST0000039798101137_5741427.0RegionD domain
TgeneMAP2K7chr19:5719715chr19:7974640ENST0000039798311237_5757436.0RegionD domain


Top

Fusion Gene Sequence for LONP1-MAP2K7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49422_49422_1_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397979_length(transcript)=3417nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGCGCTACC
AGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCC
ACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCC
ACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTG
AGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGA
AGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCA
TCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGCACCCGAGCGCATTGACCCCCCAGACC
CCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGTTGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGA
ACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACATGGGCTTCTCGGGGGACTTCC
AGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGAACACAGCTTCATCAAGCGCTACG
AGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCC
ACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAGGGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCAC
CCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGACAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCC
CGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACTGTGAACGGAAGACAGCAGGCC
GCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACC
ATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGTCCCCTGCTCTACCTCTCTGTC
CTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACCTCCTGACGGGTCCCCTGGGTC
TGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACTGCGGCTGGACGGGGCTGCGCGCTCG
CGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGTTTATTGTATTTTATTGTACTTGGTGGGGTGTTTGG
GGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACTTTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGC
CCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCA
GGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGG
AGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGAC
GTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGTGCCCCTGGCCGTCCCTCCACT
CACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACCCAGGCCAGGTGCCCCCCGGAG
CCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAAGTGGACAAGAAAAAATAACAAAACA
AAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACACCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGG
CAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATTATCATGATATTCACAAAACGCCGCATGTTTAAAAAG
TCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGG
GTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCA
GGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCA
CCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCCCCCCTCGTCACCAGCCATCCC
TCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCAATGGACCCCTCCTCAGGCCGC

>49422_49422_1_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397979_length(amino acids)=451AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD
FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF

--------------------------------------------------------------
>49422_49422_2_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397981_length(transcript)=3438nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGCGCTACC
AGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCC
ACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCC
ACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTG
AGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGA
AGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCA
TCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGCACCCGAGCGCATTGACCCCCCAGACC
CCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGTTGCCCTGCCCGTCTCCCTCCCAGGTGGAGCTGGCAA
CAGGACAGTTTCCCTACAAGAACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACA
TGGGCTTCTCGGGGGACTTCCAGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGAAC
ACAGCTTCATCAAGCGCTACGAGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCGCGGACTA
GCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAGGGGCATGGCCACAGG
CCCCCCTCCCCACTTGGCCACCCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGACAGAGAGTGGGGGGT
GCCCACCCACCCCCCCCGCCCCGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACT
GTGAACGGAAGACAGCAGGCCGCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAG
CCCTGGAGTCCCGCAGCCACCATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGT
CCCCTGCTCTACCTCTCTGTCCTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACC
TCCTGACGGGTCCCCTGGGTCTGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACTGCGG
CTGGACGGGGCTGCGCGCTCGCGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGTTTATTGTATTTTAT
TGTACTTGGTGGGGTGTTTGGGGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACTTTTACCAAAGTCACG
ATTAGCTGCTTGTGGTGGGGCCCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCT
TGGGGTGAGTTGAAGACCTCAGGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCA
TGGTGCAGAGCAGGTGACCGGAGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAG
TGGATGTGGGGGTTTGAGGACGTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGT
GCCCCTGGCCGTCCCTCCACTCACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACC
CAGGCCAGGTGCCCCCCGGAGCCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAAGTGG
ACAAGAAAAAATAACAAAACAAAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACACCAAAGGCGCAGAA
GCCGGCTGGCCGTGGTGGGGGCAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATTATCATGATATTCACA
AAACGCCGCATGTTTAAAAAGTCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGT
CAGGGGCCAGGGGTCTGCCGGGTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGG
AAGGTTGCATGGCTGGTCCCAGGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGA
GTGTGTGTCCGCCCACCCCCACCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCC
CCCCTCGTCACCAGCCATCCCTCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCA
ATGGACCCCTCCTCAGGCCGCCAGTGTCGCCCTGCCCCTTTTTAAAACAAAATGCCCTCGTTTGTAAACCCTTAGACGCTTGAGAATAAA

>49422_49422_2_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397981_length(amino acids)=458AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP
YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS

--------------------------------------------------------------
>49422_49422_3_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397983_length(transcript)=3398nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGCGCTACC
AGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCC
ACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCC
ACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTG
AGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGA
AGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCA
TCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGCACCCGAGCGCATTGACCCCCCAGACC
CCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGTTGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGA
ACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACATGGGCTTCTCGGGGGACTTCC
AGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGAACACAGCTTCATCAAGCGCTACG
AGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCC
ACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAGGGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCAC
CCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGACAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCC
CGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACTGTGAACGGAAGACAGCAGGCC
GCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACC
ATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGTCCCCTGCTCTACCTCTCTGTC
CTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACCTCCTGACGGGTCCCCTGGGTC
TGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACTGCGGCTGGACGGGGCTGCGCGCTCG
CGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGTTTATTGTATTTTATTGTACTTGGTGGGGTGTTTGG
GGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACTTTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGC
CCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCA
GGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGG
AGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGAC
GTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGTGCCCCTGGCCGTCCCTCCACT
CACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACCCAGGCCAGGTGCCCCCCGGAG
CCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAAGTGGACAAGAAAAAATAACAAAACA
AAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACACCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGG
CAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATTATCATGATATTCACAAAACGCCGCATGTTTAAAAAG
TCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGG
GTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCA
GGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCA
CCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCCCCCCTCGTCACCAGCCATCCC
TCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCAATGGACCCCTCCTCAGGCCGC

>49422_49422_3_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397983_length(amino acids)=451AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD
FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF

--------------------------------------------------------------
>49422_49422_4_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000545011_length(transcript)=3542nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGGTACCAC
CTTCACTGTGGCGGGGAGAGGGAGGAGGCCCAGCCAGGCTGGACCCATCCTGGGAGCGCCAGTGGGGGGCAGGGGGCGGTGGCAGACCAG
GGACCCTCCAACCCTCCCTCTCCTCCCAGCGCTACCAGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCG
GCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCCACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGC
GCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCCACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACG
TCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTGAGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGA
TGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGAAGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGG
ACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCATCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCG
CCTACATGGCACCCGAGCGCATTGACCCCCCAGACCCCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGT
TGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGAACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGC
TTCTGCCCGGACACATGGGCTTCTCGGGGGACTTCCAGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATA
ATAAGCTACTTGAACACAGCTTCATCAAGCGCTACGAGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTG
AGTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAG
GGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCACCCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGA
CAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCCCGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGT
CCCCCGACAGACACTGTGAACGGAAGACAGCAGGCCGCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCA
GGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACCATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCT
TCCGTCGCCCTCTGTCCCCTGCTCTACCTCTCTGTCCTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGC
CTGGGCCCAGCCACCTCCTGACGGGTCCCCTGGGTCTGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGG
GCATTGCCACTGCGGCTGGACGGGGCTGCGCGCTCGCGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAG
TTTATTGTATTTTATTGTACTTGGTGGGGTGTTTGGGGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACT
TTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGCCCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCT
CCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCAGGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAA
GGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGGAGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGAT
GGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGACGTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGT
GGTCACTCCCATCGTGCCCCTGGCCGTCCCTCCACTCACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTG
AGTGCACCGGGGACCCAGGCCAGGTGCCCCCCGGAGCCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGC
ATGCAAATCAAGTGGACAAGAAAAAATAACAAAACAAAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAAC
ACCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGGCAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATT
ATCATGATATTCACAAAACGCCGCATGTTTAAAAAGTCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCC
CCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGGGTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGC
CTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCAGGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTA
TTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCACCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCC
TCTCCCAAGACCTCCCCCCTCGTCACCAGCCATCCCTCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGG
CCAGCCCACCAGCCAATGGACCCCTCCTCAGGCCGCCAGTGTCGCCCTGCCCCTTTTTAAAACAAAATGCCCTCGTTTGTAAACCCTTAG

>49422_49422_4_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000545011_length(amino acids)=493AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQVPPSLWRGEGGGPARLDPSWERQWGAGGGGRPGTLQP
SLSSQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAM
ELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAP
ERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE

--------------------------------------------------------------
>49422_49422_5_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397979_length(transcript)=3417nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGCGCTACC
AGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCC
ACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCC
ACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTG
AGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGA
AGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCA
TCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGCACCCGAGCGCATTGACCCCCCAGACC
CCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGTTGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGA
ACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACATGGGCTTCTCGGGGGACTTCC
AGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGAACACAGCTTCATCAAGCGCTACG
AGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCC
ACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAGGGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCAC
CCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGACAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCC
CGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACTGTGAACGGAAGACAGCAGGCC
GCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACC
ATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGTCCCCTGCTCTACCTCTCTGTC
CTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACCTCCTGACGGGTCCCCTGGGTC
TGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACTGCGGCTGGACGGGGCTGCGCGCTCG
CGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGTTTATTGTATTTTATTGTACTTGGTGGGGTGTTTGG
GGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACTTTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGC
CCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCA
GGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGG
AGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGAC
GTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGTGCCCCTGGCCGTCCCTCCACT
CACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACCCAGGCCAGGTGCCCCCCGGAG
CCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAAGTGGACAAGAAAAAATAACAAAACA
AAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACACCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGG
CAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATTATCATGATATTCACAAAACGCCGCATGTTTAAAAAG
TCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGG
GTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCA
GGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCA
CCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCCCCCCTCGTCACCAGCCATCCC
TCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCAATGGACCCCTCCTCAGGCCGC

>49422_49422_5_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397979_length(amino acids)=451AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD
FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF

--------------------------------------------------------------
>49422_49422_6_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397981_length(transcript)=3438nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGCGCTACC
AGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCC
ACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCC
ACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTG
AGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGA
AGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCA
TCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGCACCCGAGCGCATTGACCCCCCAGACC
CCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGTTGCCCTGCCCGTCTCCCTCCCAGGTGGAGCTGGCAA
CAGGACAGTTTCCCTACAAGAACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACA
TGGGCTTCTCGGGGGACTTCCAGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGAAC
ACAGCTTCATCAAGCGCTACGAGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCGCGGACTA
GCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAGGGGCATGGCCACAGG
CCCCCCTCCCCACTTGGCCACCCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGACAGAGAGTGGGGGGT
GCCCACCCACCCCCCCCGCCCCGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACT
GTGAACGGAAGACAGCAGGCCGCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAG
CCCTGGAGTCCCGCAGCCACCATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGT
CCCCTGCTCTACCTCTCTGTCCTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACC
TCCTGACGGGTCCCCTGGGTCTGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACTGCGG
CTGGACGGGGCTGCGCGCTCGCGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGTTTATTGTATTTTAT
TGTACTTGGTGGGGTGTTTGGGGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACTTTTACCAAAGTCACG
ATTAGCTGCTTGTGGTGGGGCCCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCT
TGGGGTGAGTTGAAGACCTCAGGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCA
TGGTGCAGAGCAGGTGACCGGAGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAG
TGGATGTGGGGGTTTGAGGACGTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGT
GCCCCTGGCCGTCCCTCCACTCACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACC
CAGGCCAGGTGCCCCCCGGAGCCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAAGTGG
ACAAGAAAAAATAACAAAACAAAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACACCAAAGGCGCAGAA
GCCGGCTGGCCGTGGTGGGGGCAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATTATCATGATATTCACA
AAACGCCGCATGTTTAAAAAGTCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGT
CAGGGGCCAGGGGTCTGCCGGGTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGG
AAGGTTGCATGGCTGGTCCCAGGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGA
GTGTGTGTCCGCCCACCCCCACCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCC
CCCCTCGTCACCAGCCATCCCTCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCA
ATGGACCCCTCCTCAGGCCGCCAGTGTCGCCCTGCCCCTTTTTAAAACAAAATGCCCTCGTTTGTAAACCCTTAGACGCTTGAGAATAAA

>49422_49422_6_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397981_length(amino acids)=458AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP
YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS

--------------------------------------------------------------
>49422_49422_7_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397983_length(transcript)=3398nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGCGCTACC
AGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCC
ACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCC
ACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTG
AGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGA
AGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCA
TCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATGGCACCCGAGCGCATTGACCCCCCAGACC
CCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGTTGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGA
ACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCCGGACACATGGGCTTCTCGGGGGACTTCC
AGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATAATAAGCTACTTGAACACAGCTTCATCAAGCGCTACG
AGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCC
ACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAGGGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCAC
CCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGACAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCC
CGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGTCCCCCGACAGACACTGTGAACGGAAGACAGCAGGCC
GCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCAGGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACC
ATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCTTCCGTCGCCCTCTGTCCCCTGCTCTACCTCTCTGTC
CTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGCCTGGGCCCAGCCACCTCCTGACGGGTCCCCTGGGTC
TGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGGGCATTGCCACTGCGGCTGGACGGGGCTGCGCGCTCG
CGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAGTTTATTGTATTTTATTGTACTTGGTGGGGTGTTTGG
GGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACTTTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGC
CCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCTCCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCA
GGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAAGGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGG
AGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGATGGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGAC
GTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGTGGTCACTCCCATCGTGCCCCTGGCCGTCCCTCCACT
CACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTGAGTGCACCGGGGACCCAGGCCAGGTGCCCCCCGGAG
CCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGCATGCAAATCAAGTGGACAAGAAAAAATAACAAAACA
AAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAACACCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGG
CAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATTATCATGATATTCACAAAACGCCGCATGTTTAAAAAG
TCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCCCCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGG
GTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGCCTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCA
GGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTATTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCA
CCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCCTCTCCCAAGACCTCCCCCCTCGTCACCAGCCATCCC
TCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGGCCAGCCCACCAGCCAATGGACCCCTCCTCAGGCCGC

>49422_49422_7_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397983_length(amino acids)=451AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD
FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF

--------------------------------------------------------------
>49422_49422_8_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000545011_length(transcript)=3542nt_BP=234nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGCCCTGCAGCTCCCGCTGGCCAACGATGGGGGCAGCC
GCTCGCCATCCTCAGAGAGCTCCCCGCAGCACCCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACAC
CCCGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGCTACCTGACCATCGGGGGCCAGGTACCAC
CTTCACTGTGGCGGGGAGAGGGAGGAGGCCCAGCCAGGCTGGACCCATCCTGGGAGCGCCAGTGGGGGGCAGGGGGCGGTGGCAGACCAG
GGACCCTCCAACCCTCCCTCTCCTCCCAGCGCTACCAGGCAGAAATCAACGACCTGGAGAACTTGGGCGAGATGGGCAGCGGCACCTGCG
GCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCCACGTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGC
GCATCCTCATGGACCTGGATGTGGTGCTGAAGAGCCACGACTGCCCCTACATCGTGCAGTGCTTTGGGACGTTCATCACCAACACGGACG
TCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTGAGAAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGA
TGACAGTGGCGATTGTGAAGGCGCTGTACTACCTGAAGGAGAAGCACGGTGTCATCCACCGCGACGTCAAGCCCTCCAACATCCTGCTGG
ACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCATCAGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCG
CCTACATGGCACCCGAGCGCATTGACCCCCCAGACCCCACCAAGCCGGACTATGACATCCGGGCCGACGTATGGAGCCTGGGCATCTCGT
TGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGAACTGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGC
TTCTGCCCGGACACATGGGCTTCTCGGGGGACTTCCAGTCCTTCGTCAAAGACTGCCTTACTAAAGATCACAGGAAGAGACCAAAGTATA
ATAAGCTACTTGAACACAGCTTCATCAAGCGCTACGAGACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTG
AGTCACCGCGGACTAGCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAGCTGCTTGGCGGCGGCCAGCCCCACAGGGGGCCAG
GGGCATGGCCACAGGCCCCCCTCCCCACTTGGCCACCCAGCTGCCTGCCAGGGGAGACCTGGGACCTGGACGGCCACCTAGGACTGAGGA
CAGAGAGTGGGGGGTGCCCACCCACCCCCCCCGCCCCGGGCCTACCAAGCCCCCGCCCTTCCCACCCCGGGGTCAGCCGGCCGTGTGCGT
CCCCCGACAGACACTGTGAACGGAAGACAGCAGGCCGCGATCAGAGTCGCTGTTCATTCAGCCGCAGCCTCTGGGCCGGGGCGGCCCCCA
GGGGCCAGGAGAGAGCCCTGGAGTCCCGCAGCCACCATGCACGCTCCCAGCGTGCTGTGTCCTTCGCCACTCCCACGCGCCCGTTCCTCT
TCCGTCGCCCTCTGTCCCCTGCTCTACCTCTCTGTCCTTGTCTGGCTCTCCCGTCACCCTCCCTGCCTCTGTCTCTCTTCTGGCCTGAGC
CTGGGCCCAGCCACCTCCTGACGGGTCCCCTGGGTCTGCATAGGTCTCCCATGGCGCAATGAGTCAGTGGCCCCCAGCCAGGCAGTGTGG
GCATTGCCACTGCGGCTGGACGGGGCTGCGCGCTCGCGCTCTCTCTCTCTCTCTCTCTCTCTCTTTGATCTCAGGGGGTCCTTTTTGGAG
TTTATTGTATTTTATTGTACTTGGTGGGGTGTTTGGGGTGGGGGCGGAGGAGAGCTTGTTCTCGTGGGGTTGTCGGTACCTTCAGAAACT
TTTACCAAAGTCACGATTAGCTGCTTGTGGTGGGGCCCCAACCGCCCTCGGGCACTGGGGAGCTGGGCTGGGGCTGCTGCTCTGGGGTCT
CCGGGGGCCACAGCTTGGGGTGAGTTGAAGACCTCAGGGGATGTGGAGGGGTCTGCGGGGCCCTGGCCGCACAGGATGGCCTTCAGGGAA
GGTGGTCTTGGGGCATGGTGCAGAGCAGGTGACCGGAGGGAATCGGTGACGGAGCGGGGCCAAGGGAGGGGTCCGGAGGGAGTCAGGGAT
GGAGGGCAGAGGGAGTGGATGTGGGGGTTTGAGGACGTGTGACAAGCTCCAGCAGGGGTGGGGGCCGGGCTGAGGGTGGGGGTGCGAGGT
GGTCACTCCCATCGTGCCCCTGGCCGTCCCTCCACTCACCCACACCTGGCCCAGTCCACGTTGAGGTCCAGGACTGGGAAGGACCGGGTG
AGTGCACCGGGGACCCAGGCCAGGTGCCCCCCGGAGCCTGCTGGGGTGGCCAGAGCAGGAGGGGGTGTGTTTCCTTTTTGTGGGTGTTGC
ATGCAAATCAAGTGGACAAGAAAAAATAACAAAACAAAAAACAAGAAAAAAAAAACACAAAACCCCGTAAAATCACAAAGAAAATCCAAC
ACCAAAGGCGCAGAAGCCGGCTGGCCGTGGTGGGGGCAGCGTAGGCGTAGCATCCCTCTCCTCTCACTTAGCCTGTTGACTCTTGTTATT
ATCATGATATTCACAAAACGCCGCATGTTTAAAAAGTCATAGATGTCATCTTCTCTCTGCCCCCAGGGAGGAAAGCCACCTTCTCTTGCC
CCTTGGCCCCTTTGTCAGGGGCCAGGGGTCTGCCGGGTGGGGGTGCCAACAGGCCTGGCCCTTTCCTCCCCTGCATCCAGCCATGGGGGC
CTCTGCGATTGCCGGAAGGTTGCATGGCTGGTCCCAGGGCCAGCACAGGCCCGAGGCCGGGCTGCCTGGTTTTATTTTTATTTAACTTTA
TTTTCTGTTTTATGAGTGTGTGTCCGCCCACCCCCACCCCCTTCAGTGTTAAGTGGGGAGCCCTGGGGGAGTCTCTCCTGCCTCCCAGCC
TCTCCCAAGACCTCCCCCCTCGTCACCAGCCATCCCTCTGGACCAGGCAGAGGGCGGACCGGGTGGGCAGGGGCCTGAGGGTGGCTCGGG
CCAGCCCACCAGCCAATGGACCCCTCCTCAGGCCGCCAGTGTCGCCCTGCCCCTTTTTAAAACAAAATGCCCTCGTTTGTAAACCCTTAG

>49422_49422_8_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000545011_length(amino acids)=493AA_BP=73
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQVPPSLWRGEGGGPARLDPSWERQWGAGGGGRPGTLQP
SLSSQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAM
ELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAP
ERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LONP1-MAP2K7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LONP1-MAP2K7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LONP1-MAP2K7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource