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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LONP1-RAD51 (FusionGDB2 ID:49423)

Fusion Gene Summary for LONP1-RAD51

check button Fusion gene summary
Fusion gene informationFusion gene name: LONP1-RAD51
Fusion gene ID: 49423
HgeneTgene
Gene symbol

LONP1

RAD51

Gene ID

9361

5888

Gene namelon peptidase 1, mitochondrialRAD51 recombinase
SynonymsCODASS|LON|LONP|LonHS|PIM1|PRSS15|hLONBRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA
Cytomap

19p13.3

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionlon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A
Modification date2020031320200322
UniProtAcc

P36776

O15315

Ensembl transtripts involved in fusion geneENST00000360614, ENST00000540670, 
ENST00000585374, ENST00000590729, 
ENST00000593119, ENST00000590511, 
ENST00000530766, ENST00000382643, 
ENST00000423169, ENST00000532743, 
ENST00000557850, ENST00000267868, 
Fusion gene scores* DoF score18 X 14 X 12=30247 X 7 X 5=245
# samples 237
** MAII scorelog2(23/3024*10)=-3.7167523732767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LONP1 [Title/Abstract] AND RAD51 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLONP1(5700800)-RAD51(41023253), # samples:3
Anticipated loss of major functional domain due to fusion event.LONP1-RAD51 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LONP1-RAD51 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLONP1

GO:0034599

cellular response to oxidative stress

17420247

HgeneLONP1

GO:0051603

proteolysis involved in cellular protein catabolic process

8248235|17420247

TgeneRAD51

GO:0000724

double-strand break repair via homologous recombination

16428451

TgeneRAD51

GO:0006268

DNA unwinding involved in DNA replication

7988572

TgeneRAD51

GO:0006974

cellular response to DNA damage stimulus

23509288|25585578

TgeneRAD51

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

TgeneRAD51

GO:0031297

replication fork processing

25585578

TgeneRAD51

GO:0051106

positive regulation of DNA ligation

8929543

TgeneRAD51

GO:0071479

cellular response to ionizing radiation

23509288|23754376

TgeneRAD51

GO:0072757

cellular response to camptothecin

23509288


check buttonFusion gene breakpoints across LONP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD51 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EA-A50E-01ALONP1chr19

5700800

-RAD51chr15

41023253

+


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Fusion Gene ORF analysis for LONP1-RAD51

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000360614ENST00000530766LONP1chr19

5700800

-RAD51chr15

41023253

+
5CDS-3UTRENST00000540670ENST00000530766LONP1chr19

5700800

-RAD51chr15

41023253

+
5CDS-3UTRENST00000585374ENST00000530766LONP1chr19

5700800

-RAD51chr15

41023253

+
5CDS-3UTRENST00000590729ENST00000530766LONP1chr19

5700800

-RAD51chr15

41023253

+
5CDS-3UTRENST00000593119ENST00000530766LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000360614ENST00000382643LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000360614ENST00000423169LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000360614ENST00000532743LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000360614ENST00000557850LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000540670ENST00000382643LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000540670ENST00000423169LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000540670ENST00000532743LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000540670ENST00000557850LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000585374ENST00000267868LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000585374ENST00000382643LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000585374ENST00000423169LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000585374ENST00000532743LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000585374ENST00000557850LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000590729ENST00000382643LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000590729ENST00000423169LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000590729ENST00000532743LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000590729ENST00000557850LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000593119ENST00000382643LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000593119ENST00000423169LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000593119ENST00000532743LONP1chr19

5700800

-RAD51chr15

41023253

+
Frame-shiftENST00000593119ENST00000557850LONP1chr19

5700800

-RAD51chr15

41023253

+
In-frameENST00000360614ENST00000267868LONP1chr19

5700800

-RAD51chr15

41023253

+
In-frameENST00000540670ENST00000267868LONP1chr19

5700800

-RAD51chr15

41023253

+
In-frameENST00000590729ENST00000267868LONP1chr19

5700800

-RAD51chr15

41023253

+
In-frameENST00000593119ENST00000267868LONP1chr19

5700800

-RAD51chr15

41023253

+
intron-3CDSENST00000590511ENST00000267868LONP1chr19

5700800

-RAD51chr15

41023253

+
intron-3CDSENST00000590511ENST00000382643LONP1chr19

5700800

-RAD51chr15

41023253

+
intron-3CDSENST00000590511ENST00000423169LONP1chr19

5700800

-RAD51chr15

41023253

+
intron-3CDSENST00000590511ENST00000532743LONP1chr19

5700800

-RAD51chr15

41023253

+
intron-3CDSENST00000590511ENST00000557850LONP1chr19

5700800

-RAD51chr15

41023253

+
intron-3UTRENST00000590511ENST00000530766LONP1chr19

5700800

-RAD51chr15

41023253

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360614LONP1chr195700800-ENST00000267868RAD51chr1541023253+27661664381732564
ENST00000593119LONP1chr195700800-ENST00000267868RAD51chr1541023253+24491347331415460
ENST00000540670LONP1chr195700800-ENST00000267868RAD51chr1541023253+253314313691499376
ENST00000590729LONP1chr195700800-ENST00000267868RAD51chr1541023253+22771175591243394

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360614ENST00000267868LONP1chr195700800-RAD51chr1541023253+0.0023729930.9976271
ENST00000593119ENST00000267868LONP1chr195700800-RAD51chr1541023253+0.0019229950.99807703
ENST00000540670ENST00000267868LONP1chr195700800-RAD51chr1541023253+0.0019831710.99801683
ENST00000590729ENST00000267868LONP1chr195700800-RAD51chr1541023253+0.0011300070.99886996

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Fusion Genomic Features for LONP1-RAD51


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LONP1chr195700799-RAD51chr1541023252+1.26E-060.9999987
LONP1chr195700799-RAD51chr1541023252+1.26E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LONP1-RAD51


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5700800/chr15:41023253)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LONP1

P36776

RAD51

O15315

FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:8248235}.FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP1chr19:5700800chr15:41023253ENST00000360614-918124_368502960.0DomainLon N-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP1chr19:5700800chr15:41023253ENST00000360614-918759_949502960.0DomainLon proteolytic
HgeneLONP1chr19:5700800chr15:41023253ENST00000360614-918523_530502960.0Nucleotide bindingATP
TgeneRAD51chr19:5700800chr15:41023253ENST0000026786881048_77298340.0DomainNote=HhH
TgeneRAD51chr19:5700800chr15:41023253ENST0000038264381048_77299341.0DomainNote=HhH
TgeneRAD51chr19:5700800chr15:41023253ENST000004231697948_77258281.0DomainNote=HhH
TgeneRAD51chr19:5700800chr15:41023253ENST0000053274381048_77299341.0DomainNote=HhH
TgeneRAD51chr19:5700800chr15:41023253ENST000005578506848_77201243.0DomainNote=HhH
TgeneRAD51chr19:5700800chr15:41023253ENST00000267868810127_134298340.0Nucleotide bindingATP
TgeneRAD51chr19:5700800chr15:41023253ENST00000382643810127_134299341.0Nucleotide bindingATP
TgeneRAD51chr19:5700800chr15:41023253ENST0000042316979127_134258281.0Nucleotide bindingATP
TgeneRAD51chr19:5700800chr15:41023253ENST00000532743810127_134299341.0Nucleotide bindingATP
TgeneRAD51chr19:5700800chr15:41023253ENST0000055785068127_134201243.0Nucleotide bindingATP


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Fusion Gene Sequence for LONP1-RAD51


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49423_49423_1_LONP1-RAD51_LONP1_chr19_5700800_ENST00000360614_RAD51_chr15_41023253_ENST00000267868_length(transcript)=2766nt_BP=1664nt
CGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTACCGAGGCACGCGCCG
GGCGTCACGTGCGTTTCGCGGCGAGCGGAAATGACGCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACG
TGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGT
GGTTGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGGGCCAATGGCGGGGGT
TTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGG
GGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCG
CCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTC
GTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACA
CGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCA
GACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGG
ACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACG
TTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACC
CTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGC
TCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGA
AGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGG
AGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGC
TCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCA
CCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGG
AGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATC
TACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTT
TTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCC
AGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAA
TGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGG
AATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCT
AAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGC
AGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACC
ATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCT
GTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCAT
CTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACT
TAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGA

>49423_49423_1_LONP1-RAD51_LONP1_chr19_5700800_ENST00000360614_RAD51_chr15_41023253_ENST00000267868_length(amino acids)=564AA_BP=542
MKRLFRATRPSGTEARAGRHVRFAASGNDASCVSRQYGRAMAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASP
PWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIK
IIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAE
NKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQA
GQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLE
KDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKR

--------------------------------------------------------------
>49423_49423_2_LONP1-RAD51_LONP1_chr19_5700800_ENST00000540670_RAD51_chr15_41023253_ENST00000267868_length(transcript)=2533nt_BP=1431nt
AGACGAATCCCGGGAAGCCCGAATCCGCGCACCCCAAAGTGCGCTCAGAGCCTGAGTATGCGCACCCGGCCACCCGTGGCCAGTCTAGAG
TCTGAGCATGCGCATGTTGTCCGCGCGCCTAAGCATGTGCACAGGCTGCTCATGAGTTCCTAAACGTTGCGTTTGCAACACTACCAGTGT
TTTGTACGGGCGCTGGCGCCTGCTCACAGCCTTCCACGTGACCGGAAAAGGCCTTCAGCGCATAAAGTGGGAGACCGGAAGAGGCGGAGA
CGATCCGATGCTCGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTTAAA
AATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAG
TCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGC
ATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCC
CGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAG
CTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAG
ATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTG
GACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATT
CCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAG
AAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGAT
GCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTG
GGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTACAGCAAC
GAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATTGTATCT
GAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGA
TGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCC
TGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAA
ACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGA
GGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGA
ACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTG
CACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAG
TCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGT
CTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAG
TTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAG
TCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCA
GCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGGCTTCTAATAAAGTA

>49423_49423_2_LONP1-RAD51_LONP1_chr19_5700800_ENST00000540670_RAD51_chr15_41023253_ENST00000267868_length(amino acids)=376AA_BP=354
MVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRK
SKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNP
IYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIE
EKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILIVSEER

--------------------------------------------------------------
>49423_49423_3_LONP1-RAD51_LONP1_chr19_5700800_ENST00000590729_RAD51_chr15_41023253_ENST00000267868_length(transcript)=2277nt_BP=1175nt
GCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGC
CGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAA
GGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAA
TCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCC
ATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGG
AGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGG
CCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTG
GCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGG
AAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGC
GGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGA
AGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGG
AGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGG
GCAAGTACAGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCA
TCCTGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTC
GCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAG
AGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTT
TTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTT
TCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTT
ATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAA
AGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGG
TTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAA
GATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCG
CTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTT
ACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGC
ACTGCTGCATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGG

>49423_49423_3_LONP1-RAD51_LONP1_chr19_5700800_ENST00000590729_RAD51_chr15_41023253_ENST00000267868_length(amino acids)=394AA_BP=372
MTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKL
RMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEALTAEIVKTIRDIIALNPLY
RESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQL
KIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEED

--------------------------------------------------------------
>49423_49423_4_LONP1-RAD51_LONP1_chr19_5700800_ENST00000593119_RAD51_chr15_41023253_ENST00000267868_length(transcript)=2449nt_BP=1347nt
GCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTG
CGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCCGGTCATAACGGCGCTCACG
CCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAG
GTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGC
AATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAG
CTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCAC
AAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACC
CCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACT
GCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGG
GTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACC
AATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTG
GAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGAC
AAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGC
AAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAATGTCACCCGCAACTACCTAGACTGGCTCACGTCCATCCCTTGGGGCAAGTAC
AGCAACGAGAACCTGGACCTGGCGCGGGCACAGGCAGTGCTGGAGGAAGACCACTACGGCATGGAGGACGTCAAGAAACGCATCCTGATT
GTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAA
TGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACT
GCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATG
GTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGT
TTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCC
AAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATG
GGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTT
ATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCC
TAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCC
CAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGC
CTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGC
ATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGGCTTCTAAT

>49423_49423_4_LONP1-RAD51_LONP1_chr19_5700800_ENST00000593119_RAD51_chr15_41023253_ENST00000267868_length(amino acids)=460AA_BP=438
MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLR
RKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKK
EAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDM
GAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRER
LKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILIVSEERKRGNQN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LONP1-RAD51


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRAD51chr19:5700800chr15:41023253ENST00000267868810184_257298.6666666666667340.0PALB2
TgeneRAD51chr19:5700800chr15:41023253ENST00000382643810184_257299.6666666666667341.0PALB2
TgeneRAD51chr19:5700800chr15:41023253ENST0000042316979184_257258.0281.0PALB2
TgeneRAD51chr19:5700800chr15:41023253ENST00000532743810184_257299.6666666666667341.0PALB2
TgeneRAD51chr19:5700800chr15:41023253ENST0000055785068184_257201.66666666666666243.0PALB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LONP1-RAD51


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LONP1-RAD51


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource