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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LONP1-SAFB2 (FusionGDB2 ID:49426)

Fusion Gene Summary for LONP1-SAFB2

check button Fusion gene summary
Fusion gene informationFusion gene name: LONP1-SAFB2
Fusion gene ID: 49426
HgeneTgene
Gene symbol

LONP1

SAFB2

Gene ID

9361

9667

Gene namelon peptidase 1, mitochondrialscaffold attachment factor B2
SynonymsCODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON-
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionlon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15scaffold attachment factor B2
Modification date2020031320200313
UniProtAcc

P36776

.
Ensembl transtripts involved in fusion geneENST00000360614, ENST00000540670, 
ENST00000585374, ENST00000590729, 
ENST00000593119, ENST00000590511, 
ENST00000591310, ENST00000252542, 
Fusion gene scores* DoF score18 X 14 X 12=30248 X 8 X 5=320
# samples 239
** MAII scorelog2(23/3024*10)=-3.7167523732767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LONP1 [Title/Abstract] AND SAFB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSAFB2(5598804)-LONP1(5708414), # samples:3
LONP1(5705783)-SAFB2(5600271), # samples:1
LONP1(5705782)-SAFB2(5604947), # samples:1
Anticipated loss of major functional domain due to fusion event.SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SAFB2-LONP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LONP1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LONP1-SAFB2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LONP1-SAFB2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
LONP1-SAFB2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLONP1

GO:0034599

cellular response to oxidative stress

17420247

HgeneLONP1

GO:0051603

proteolysis involved in cellular protein catabolic process

8248235|17420247


check buttonFusion gene breakpoints across LONP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SAFB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A251-01ALONP1chr19

5705783

-SAFB2chr19

5600271

-
ChimerDB4BRCATCGA-AR-A251LONP1chr19

5705782

-SAFB2chr19

5604947

-


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Fusion Gene ORF analysis for LONP1-SAFB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000360614ENST00000591310LONP1chr19

5705783

-SAFB2chr19

5600271

-
5CDS-5UTRENST00000360614ENST00000591310LONP1chr19

5705782

-SAFB2chr19

5604947

-
5CDS-5UTRENST00000540670ENST00000591310LONP1chr19

5705783

-SAFB2chr19

5600271

-
5CDS-5UTRENST00000540670ENST00000591310LONP1chr19

5705782

-SAFB2chr19

5604947

-
5CDS-5UTRENST00000585374ENST00000591310LONP1chr19

5705783

-SAFB2chr19

5600271

-
5CDS-5UTRENST00000585374ENST00000591310LONP1chr19

5705782

-SAFB2chr19

5604947

-
5CDS-5UTRENST00000590729ENST00000591310LONP1chr19

5705783

-SAFB2chr19

5600271

-
5CDS-5UTRENST00000590729ENST00000591310LONP1chr19

5705782

-SAFB2chr19

5604947

-
5CDS-5UTRENST00000593119ENST00000591310LONP1chr19

5705783

-SAFB2chr19

5600271

-
5CDS-5UTRENST00000593119ENST00000591310LONP1chr19

5705782

-SAFB2chr19

5604947

-
Frame-shiftENST00000360614ENST00000252542LONP1chr19

5705782

-SAFB2chr19

5604947

-
Frame-shiftENST00000540670ENST00000252542LONP1chr19

5705782

-SAFB2chr19

5604947

-
Frame-shiftENST00000585374ENST00000252542LONP1chr19

5705783

-SAFB2chr19

5600271

-
Frame-shiftENST00000590729ENST00000252542LONP1chr19

5705782

-SAFB2chr19

5604947

-
Frame-shiftENST00000593119ENST00000252542LONP1chr19

5705782

-SAFB2chr19

5604947

-
In-frameENST00000360614ENST00000252542LONP1chr19

5705783

-SAFB2chr19

5600271

-
In-frameENST00000540670ENST00000252542LONP1chr19

5705783

-SAFB2chr19

5600271

-
In-frameENST00000585374ENST00000252542LONP1chr19

5705782

-SAFB2chr19

5604947

-
In-frameENST00000590729ENST00000252542LONP1chr19

5705783

-SAFB2chr19

5600271

-
In-frameENST00000593119ENST00000252542LONP1chr19

5705783

-SAFB2chr19

5600271

-
intron-3CDSENST00000590511ENST00000252542LONP1chr19

5705783

-SAFB2chr19

5600271

-
intron-3CDSENST00000590511ENST00000252542LONP1chr19

5705782

-SAFB2chr19

5604947

-
intron-5UTRENST00000590511ENST00000591310LONP1chr19

5705783

-SAFB2chr19

5600271

-
intron-5UTRENST00000590511ENST00000591310LONP1chr19

5705782

-SAFB2chr19

5604947

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360614LONP1chr195705783-ENST00000252542SAFB2chr195600271-30721525382827929
ENST00000593119LONP1chr195705783-ENST00000252542SAFB2chr195600271-27551208332510825
ENST00000540670LONP1chr195705783-ENST00000252542SAFB2chr195600271-283912923692594741
ENST00000590729LONP1chr195705783-ENST00000252542SAFB2chr195600271-25831036592338759
ENST00000585374LONP1chr195705782-ENST00000252542SAFB2chr195604947-2982117212382737499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360614ENST00000252542LONP1chr195705783-SAFB2chr195600271-0.0052758760.9947241
ENST00000593119ENST00000252542LONP1chr195705783-SAFB2chr195600271-0.0092834510.9907165
ENST00000540670ENST00000252542LONP1chr195705783-SAFB2chr195600271-0.0163484770.9836516
ENST00000590729ENST00000252542LONP1chr195705783-SAFB2chr195600271-0.006648260.99335176
ENST00000585374ENST00000252542LONP1chr195705782-SAFB2chr195604947-0.0333741530.9666258

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Fusion Genomic Features for LONP1-SAFB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LONP1-SAFB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5598804/chr19:5708414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LONP1

P36776

.
FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:8248235}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP1chr19:5705782chr19:5604947ENST00000360614-818124_368455960.0DomainLon N-terminal
HgeneLONP1chr19:5705783chr19:5600271ENST00000360614-818124_368455960.0DomainLon N-terminal
TgeneSAFB2chr19:5705782chr19:5604947ENST00000252542821482_545432954.0Compositional biasNote=Lys-rich
TgeneSAFB2chr19:5705782chr19:5604947ENST00000252542821619_724432954.0Compositional biasNote=Glu-rich
TgeneSAFB2chr19:5705782chr19:5604947ENST00000252542821621_788432954.0Compositional biasNote=Arg-rich
TgeneSAFB2chr19:5705782chr19:5604947ENST00000252542821792_926432954.0Compositional biasNote=Gly-rich
TgeneSAFB2chr19:5705783chr19:5600271ENST000002525421021619_724519954.0Compositional biasNote=Glu-rich
TgeneSAFB2chr19:5705783chr19:5600271ENST000002525421021621_788519954.0Compositional biasNote=Arg-rich
TgeneSAFB2chr19:5705783chr19:5600271ENST000002525421021792_926519954.0Compositional biasNote=Gly-rich
TgeneSAFB2chr19:5705782chr19:5604947ENST00000252542821713_730432954.0MotifNuclear localization signal
TgeneSAFB2chr19:5705783chr19:5600271ENST000002525421021713_730519954.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP1chr19:5705782chr19:5604947ENST00000360614-818759_949455960.0DomainLon proteolytic
HgeneLONP1chr19:5705783chr19:5600271ENST00000360614-818759_949455960.0DomainLon proteolytic
HgeneLONP1chr19:5705782chr19:5604947ENST00000360614-818523_530455960.0Nucleotide bindingATP
HgeneLONP1chr19:5705783chr19:5600271ENST00000360614-818523_530455960.0Nucleotide bindingATP
TgeneSAFB2chr19:5705783chr19:5600271ENST000002525421021482_545519954.0Compositional biasNote=Lys-rich
TgeneSAFB2chr19:5705782chr19:5604947ENST0000025254282130_64432954.0DomainSAP
TgeneSAFB2chr19:5705782chr19:5604947ENST00000252542821407_485432954.0DomainRRM
TgeneSAFB2chr19:5705783chr19:5600271ENST00000252542102130_64519954.0DomainSAP
TgeneSAFB2chr19:5705783chr19:5600271ENST000002525421021407_485519954.0DomainRRM


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Fusion Gene Sequence for LONP1-SAFB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49426_49426_1_LONP1-SAFB2_LONP1_chr19_5705782_ENST00000585374_SAFB2_chr19_5604947_ENST00000252542_length(transcript)=2982nt_BP=1172nt
AGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCG
CCGCCGGGGGGCGGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCG
CTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGG
AAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATC
TACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCAT
ATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAG
GCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTA
GAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCC
TTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGC
GCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTG
CTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTG
CTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTG
AAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTC
AAGTTGTCGGGGCCAAAGTGGTAACGAACGCCCGCAGCCCGGGGGCTCGATGCTATGGATTCGTCACCATGTCGACATCTGACGAGGCGA
CCAAGTGCATCAGCCATCTCCACAGAACTGAGCTGCATGGACGAATGATCTCCGTAGAGAAGGCCAAAAATGAGCCTGCTGGGAAAAAGC
TTTCCGACAGAAAAGAGTGCGAAGTGAAGAAGGAAAAATTATCGAGTGTCGACAGACATCATTCTGTGGAGATCAAAATTGAAAAAACTG
TAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAAC
CCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCG
TCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCT
TGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGC
GCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGT
GCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGC
AGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCT
ACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAG
ACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGG
GAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCT
GGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACC
AGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCG
AGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATT
CCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTC
ATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTA
GCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTT
TTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATCAAGGTTTCTGTTAACGAGGCATTCCATTTTCCATTAATAAAGT

>49426_49426_1_LONP1-SAFB2_LONP1_chr19_5705782_ENST00000585374_SAFB2_chr19_5604947_ENST00000252542_length(amino acids)=499AA_BP=163
MSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVEIKIEKTVIKKEEKIEKKEEKKPEDIKKEE
KDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIR
ETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQE
RRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERH
GRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRG

--------------------------------------------------------------
>49426_49426_2_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000360614_SAFB2_chr19_5600271_ENST00000252542_length(transcript)=3072nt_BP=1525nt
CGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTACCGAGGCACGCGCCG
GGCGTCACGTGCGTTTCGCGGCGAGCGGAAATGACGCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACG
TGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTGCGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGT
GGTTGCTCCGAGGCCAGCGGACCTGCGACGCCTCTCCTCCTTGGGCACTGTGGGGCCGAGGCCCGGCAATTGGGGGCCAATGGCGGGGGT
TTTGGGAAGCGAGCAGCCGCGGCGGAGGCGCATTCTCGGGGGGCGAGGACGCCTCCGAGGGCGGCGCGGAGGAAGGAGCCGGCGGCGCGG
GGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCG
CCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTC
GTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACA
CGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCA
GACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGG
ACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACG
TTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACC
CTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGC
TCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGA
AGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGG
AGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGC
TCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTG
TAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAAC
CCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCG
TCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCT
TGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGC
GCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGT
GCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGC
AGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCT
ACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAG
ACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGG
GAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCT
GGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACC
AGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCG
AGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATT
CCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTC
ATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTA
GCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTT
TTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATCAAGGTTTCTGTTAACGAGGCATTCCATTTTCCATTAATAAAGT

>49426_49426_2_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000360614_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=929AA_BP=1
MKRLFRATRPSGTEARAGRHVRFAASGNDASCVSRQYGRAMAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASP
PWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIK
IIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAE
NKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQA
GQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLE
KDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSG
SRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAF
HERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPE
GKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEG
RGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEG

--------------------------------------------------------------
>49426_49426_3_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000540670_SAFB2_chr19_5600271_ENST00000252542_length(transcript)=2839nt_BP=1292nt
AGACGAATCCCGGGAAGCCCGAATCCGCGCACCCCAAAGTGCGCTCAGAGCCTGAGTATGCGCACCCGGCCACCCGTGGCCAGTCTAGAG
TCTGAGCATGCGCATGTTGTCCGCGCGCCTAAGCATGTGCACAGGCTGCTCATGAGTTCCTAAACGTTGCGTTTGCAACACTACCAGTGT
TTTGTACGGGCGCTGGCGCCTGCTCACAGCCTTCCACGTGACCGGAAAAGGCCTTCAGCGCATAAAGTGGGAGACCGGAAGAGGCGGAGA
CGATCCGATGCTCGAACTCCGCCCCCTCTTCTCCGCGTAGGCCCAGCTCCCTGAAGCGGCTGTTTCGAGCCACGCGCCCATCGGGTTAAA
AATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAG
TCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGC
ATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCC
CGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAG
CTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACTGCAGAG
ATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGGGTGGTG
GACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACCAATATT
CCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTGGAGGAG
AAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGACAAGGAT
GCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGCAAGCTG
GGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCTGAAGAC
ATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGAATGGAG
CGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAGAGTCAG
GATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGGCAGCGG
GAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGGAAGGAG
AAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTGGAGCGC
GAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAGCAGCTG
CGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGTGTGGCA
ATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAGGACCAC
GCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCACGGAGGA
CCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTGCCCCCT
CCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGACGCAGGC
GCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGCGGTGGA
GTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTGGCCAGC
CAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTCGCTGCG
AGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAATCCTGC
CACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATCAAGGTT

>49426_49426_3_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000540670_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=741AA_BP=1
MVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRK
SKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNP
IYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIE
EKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTV
VMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKAR
LQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMED
RYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPR
GGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDR

--------------------------------------------------------------
>49426_49426_4_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000590729_SAFB2_chr19_5600271_ENST00000252542_length(transcript)=2583nt_BP=1036nt
GCGGCGCGGGGGGCAGCGCGGGCGCCGGGGAAGGCCCGGTCATAACGGCGCTCACGCCCATGACGATCCCCGATGTGTTTCCGCACCTGC
CGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAGGTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAA
GGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGCAATGAGTCGGATGTGGTCGAGAGCCTGGATGAAA
TCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAGCTGCGCATGATCGTCATGGGACACAGAAGAGTCC
ATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCACAAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGG
AGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACCCCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGG
CCCTGACTGCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTG
GCCAGCGGGTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGG
AAGAGACCAATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGC
GGGAGGTGGAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGA
AGGACGACAAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGG
AGCTGAGCAAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAA
AAAAGCCTGAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAA
GCAGAGGAATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAA
GCTCCAAGAGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGC
GCCAGAGGCAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCC
ATGAGCGGAAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGG
AGCGGCTGGAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCC
AGCAGGAGCAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAG
GAAAGCGTGTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCC
AGTACCAGGACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCC
ATGGCCACGGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCC
GGGGGCTGCCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTG
CCATGGACGCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGG
CAAGCCGCGGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTG
GCGGAGTGGCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAG
TCCCACTCGCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGC
AAAGTAAATCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATT

>49426_49426_4_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000590729_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=759AA_BP=0
MTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKL
RMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEALTAEIVKTIRDIIALNPLY
RESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQL
KIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGP
TNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQ
REREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDL
DRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGG
YGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQG

--------------------------------------------------------------
>49426_49426_5_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000593119_SAFB2_chr19_5600271_ENST00000252542_length(transcript)=2755nt_BP=1208nt
GCGAGTTGTGTGAGCCGCCAGTATGGCCGGGCTATGGCGGCGAGCACTGGCTACGTGCGACTGTGGGGAGCGGCGCGGTGCTGGGTGCTG
CGGCGGCCGATGCTGGCCGCCGCCGGGGGGCGGGTTCCCACTGCAGCAGGAGCGTGGTTGCTCCGAGGCCCGGTCATAACGGCGCTCACG
CCCATGACGATCCCCGATGTGTTTCCGCACCTGCCGCTCATCGCCATCACCCGCAACCCGGTGTTCCCGCGCTTTATCAAGATTATCGAG
GTTAAAAATAAGAAGTTGGTTGAGCTGCTGAGAAGGAAAGTTCGTCTCGCCCAGCCTTATGTCGGCGTCTTTCTAAAGAGAGATGACAGC
AATGAGTCGGATGTGGTCGAGAGCCTGGATGAAATCTACCACACGGGGACGTTTGCCCAGATCCATGAGATGCAGGACCTTGGGGACAAG
CTGCGCATGATCGTCATGGGACACAGAAGAGTCCATATCAGCAGACAGCTGGAGGTGGAGCCCGAGGAGCCGGAGGCGGAGAACAAGCAC
AAGCCCCGCAGGAAGTCAAAGCGGGGCAAGAAGGAGGCGGAGGACGAGCTGAGCGCCAGGCACCCGGCGGAGCTGGCGATGGAGCCCACC
CCTGAGCTCCCGGCTGAGGTGCTCATGGTGGAGGTAGAGAACGTTGTCCACGAGGACTTCCAGGTCACGGAGGAGGTGAAAGCCCTGACT
GCAGAGATCGTGAAGACCATCCGGGACATCATTGCCTTGAACCCTCTCTACAGGGAGTCAGTGCTGCAGATGATGCAGGCTGGCCAGCGG
GTGGTGGACAACCCCATCTACCTGAGCGACATGGGCGCCGCGCTCACCGGGGCCGAGTCCCATGAGCTGCAGGACGTCCTGGAAGAGACC
AATATTCCTAAGCGGCTGTACAAGGCCCTCTCCCTGCTGAAGAAGGAATTTGAACTGAGCAAGCTGCAGCAGCGCCTGGGGCGGGAGGTG
GAGGAGAAGATCAAGCAGACCCACCGTAAGTACCTGCTGCAGGAGCAGCTAAAGATCATCAAGAAGGAGCTGGGCCTGGAGAAGGACGAC
AAGGATGCCATCGAGGAGAAGTTCCGGGAGCGCCTGAAGGAGCTCGTGGTCCCCAAGCACGTCATGGATGTTGTGGACGAGGAGCTGAGC
AAGCTGGGCCTGCTGGACAACCACTCCTCGGAGTTCAAAACTGTAATTAAGAAGGAAGAGAAGATTGAGAAGAAGGAGGAAAAAAAGCCT
GAAGACATTAAGAAGGAAGAAAAAGACCAGGATGAGCTGAAACCCGGACCTACAAATCGGTCTAGAGTCACCAAATCAGGAAGCAGAGGA
ATGGAGCGGACGGTCGTGATGGATAAATCGAAAGGAGAGCCCGTCATTAGCGTGAAAACCACAAGCAGGTCCAAAGAGAGAAGCTCCAAG
AGTCAGGATCGCAAGTCAGAAAGCAAAGAAAAGAGAGACATCTTGTCGTTTGATAAAATCAAAGAACAAAGGGAGAGAGAGCGCCAGAGG
CAGCGGGAACGGGAGATCCGCGAAACGGAGAGGCGGCGGGAGCGCGAGCAGCGGGAGCGGGAGCAACGCCTCGAGGCCTTCCATGAGCGG
AAGGAGAAGGCCCGGCTACAGCGGGAACGCCTGCAGCTCGAGTGCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAGCGGCTG
GAGCGCGAGCGCATGCGCGTGGAGCGTGAGCGCAGGAAGGAGCAGGAGCGCATCCACCGCGAGCGCGAGGAGCTGCGGCGCCAGCAGGAG
CAGCTGCGTTACGAGCAGGAGCGGCGGCCCGGGCGGAGGCCCTACGACCTGGACCGACGAGATGATGCCTATTGGCCAGAAGGAAAGCGT
GTGGCAATGGAGGACCGATATCGTGCAGACTTTCCCCGGCCAGACCACCGCTTTCACGACTTCGATCATCGAGACCGGGGCCAGTACCAG
GACCACGCCATCGACAGGCGGGAGGGTTCGAGGCCAATGATGGGAGACCACCGGGATGGGCAGCACTATGGAGATGACCGCCATGGCCAC
GGAGGACCCCCAGAGCGCCACGGCCGGGACTCCCGTGATGGCTGGGGGGGCTACGGCTCCGACAAGAGGCTGAGTGAAGGCCGGGGGCTG
CCCCCTCCCCCCAGGGGTGGCCGTGACTGGGGAGAGCACAACCAGCGGCTAGAGGAGCACCAGGCACGCGCCTGGCAGGGTGCCATGGAC
GCAGGCGCGGCTAGCCGGGAGCACGCCAGGTGGCAAGGTGGCGAGAGGGGCCTGTCTGGGCCCTCGGGGCCGGGGCACATGGCAAGCCGC
GGTGGAGTGGCGGGGCGAGGCGGCTTTGCACAAGGTGGACATTCCCAGGGCCACGTGGTGCCAGGTGGCGGACTGGAAGGTGGCGGAGTG
GCCAGCCAGGACCGGGGCAGCAGAGTCCCTCACCCACACCCTCATCCCCCCCCGTACCCCCACTTCACCCGCCGCTACTAAGTCCCACTC
GCTGCGAGTTTTCGGGTGGGCAGACGCACTGTTGAATCTGGTAGCCAGGGTTCCCTCGAACTTGGGGGATCTTTTTAAAAGCAAAGTAAA
TCCTGCCACCATGTTGTAGCTCAATACAATGTGAACTCACTTTTTTTTTTTTTTTAAATAAATGTGTTCTTGTTCTGCCATTTTTAAATC

>49426_49426_5_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000593119_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=825AA_BP=0
MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLR
RKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKK
EAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDM
GAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRER
LKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSK
GEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERL
QLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADF
PRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWG
EHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDRGSRVPH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LONP1-SAFB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSAFB2chr19:5705782chr19:5604947ENST00000252542821600_953432.0954.0SAFB1
TgeneSAFB2chr19:5705783chr19:5600271ENST000002525421021600_953519.6666666666666954.0SAFB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LONP1-SAFB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LONP1-SAFB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource