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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LONP2-HIRA (FusionGDB2 ID:49433)

Fusion Gene Summary for LONP2-HIRA

check button Fusion gene summary
Fusion gene informationFusion gene name: LONP2-HIRA
Fusion gene ID: 49433
HgeneTgene
Gene symbol

LONP2

HIRA

Gene ID

83752

7290

Gene namelon peptidase 2, peroxisomalhistone cell cycle regulator
SynonymsLONP|LONPL|PLON|PSLONDGCR1|TUP1|TUPLE1
Cytomap

16q12.1

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionlon protease homolog 2, peroxisomallon protease 2lon protease-like protein 2peroxisomal LON protease likeperoxisomal Lon protease homolog 2protein HIRADiGeorge critical region gene 1HIR histone cell cycle regulation defective homolog ATUP1-like enhancer of split protein 1histone regulator A
Modification date2020031320200313
UniProtAcc

Q86WA8

P54198

Ensembl transtripts involved in fusion geneENST00000285737, ENST00000535754, 
ENST00000564259, 		ENST00000464189, 
ENST00000541063, ENST00000546308, 
ENST00000263208, ENST00000340170, 
Fusion gene scores* DoF score10 X 9 X 5=4507 X 6 X 4=168
# samples 117
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LONP2 [Title/Abstract] AND HIRA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLONP2(48337216)-HIRA(19398301), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHIRA

GO:0006336

DNA replication-independent nucleosome assembly

14718166


check buttonFusion gene breakpoints across LONP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HIRA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-4112-01ALONP2chr16

48337216

-HIRAchr22

19398301

-
ChimerDB4LUADTCGA-44-4112-01ALONP2chr16

48337216

+HIRAchr22

19398301

-


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Fusion Gene ORF analysis for LONP2-HIRA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000285737ENST00000464189LONP2chr16

48337216

+HIRAchr22

19398301

-
5CDS-5UTRENST00000285737ENST00000541063LONP2chr16

48337216

+HIRAchr22

19398301

-
5CDS-5UTRENST00000285737ENST00000546308LONP2chr16

48337216

+HIRAchr22

19398301

-
5CDS-5UTRENST00000535754ENST00000464189LONP2chr16

48337216

+HIRAchr22

19398301

-
5CDS-5UTRENST00000535754ENST00000541063LONP2chr16

48337216

+HIRAchr22

19398301

-
5CDS-5UTRENST00000535754ENST00000546308LONP2chr16

48337216

+HIRAchr22

19398301

-
In-frameENST00000285737ENST00000263208LONP2chr16

48337216

+HIRAchr22

19398301

-
In-frameENST00000285737ENST00000340170LONP2chr16

48337216

+HIRAchr22

19398301

-
In-frameENST00000535754ENST00000263208LONP2chr16

48337216

+HIRAchr22

19398301

-
In-frameENST00000535754ENST00000340170LONP2chr16

48337216

+HIRAchr22

19398301

-
intron-3CDSENST00000564259ENST00000263208LONP2chr16

48337216

+HIRAchr22

19398301

-
intron-3CDSENST00000564259ENST00000340170LONP2chr16

48337216

+HIRAchr22

19398301

-
intron-5UTRENST00000564259ENST00000464189LONP2chr16

48337216

+HIRAchr22

19398301

-
intron-5UTRENST00000564259ENST00000541063LONP2chr16

48337216

+HIRAchr22

19398301

-
intron-5UTRENST00000564259ENST00000546308LONP2chr16

48337216

+HIRAchr22

19398301

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285737LONP2chr1648337216+ENST00000340170HIRAchr2219398301-502618889342831396
ENST00000285737LONP2chr1648337216+ENST00000263208HIRAchr2219398301-564718889349041603
ENST00000535754LONP2chr1648337216+ENST00000340170HIRAchr2219398301-485717195641141352
ENST00000535754LONP2chr1648337216+ENST00000263208HIRAchr2219398301-547817195647351559

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285737ENST00000340170LONP2chr1648337216+HIRAchr2219398301-0.0023645370.9976355
ENST00000285737ENST00000263208LONP2chr1648337216+HIRAchr2219398301-0.0014079770.99859196
ENST00000535754ENST00000340170LONP2chr1648337216+HIRAchr2219398301-0.0023257770.99767417
ENST00000535754ENST00000263208LONP2chr1648337216+HIRAchr2219398301-0.001417840.9985821

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Fusion Genomic Features for LONP2-HIRA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LONP2-HIRA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:48337216/chr22:19398301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LONP2

Q86WA8

HIRA

P54198

FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}.FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP2chr16:48337216chr22:19398301ENST00000285737+111513_220598853.0DomainLon N-terminal
HgeneLONP2chr16:48337216chr22:19398301ENST00000285737+1115375_382598853.0Nucleotide bindingATP
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025408_412121018.0Compositional biasNote=Poly-Gln
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025640_643121018.0Compositional biasNote=Poly-Lys
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025805_808121018.0Compositional biasNote=Poly-Val
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021408_41212811.0Compositional biasNote=Poly-Gln
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021640_64312811.0Compositional biasNote=Poly-Lys
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021805_80812811.0Compositional biasNote=Poly-Val
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025439_475121018.0RegionNote=Required for repression of histone gene transcription
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021439_47512811.0RegionNote=Required for repression of histone gene transcription
TgeneHIRAchr16:48337216chr22:19398301ENST0000026320802511_53121018.0RepeatNote=WD 1
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025129_168121018.0RepeatNote=WD 3
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025172_211121018.0RepeatNote=WD 4
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025220_263121018.0RepeatNote=WD 5
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025266_322121018.0RepeatNote=WD 6
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025326_367121018.0RepeatNote=WD 7
TgeneHIRAchr16:48337216chr22:19398301ENST0000026320802568_107121018.0RepeatNote=WD 2
TgeneHIRAchr16:48337216chr22:19398301ENST0000034017002111_5312811.0RepeatNote=WD 1
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021129_16812811.0RepeatNote=WD 3
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021172_21112811.0RepeatNote=WD 4
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021220_26312811.0RepeatNote=WD 5
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021266_32212811.0RepeatNote=WD 6
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021326_36712811.0RepeatNote=WD 7
TgeneHIRAchr16:48337216chr22:19398301ENST0000034017002168_10712811.0RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLONP2chr16:48337216chr22:19398301ENST00000285737+1115651_837598853.0DomainLon proteolytic


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Fusion Gene Sequence for LONP2-HIRA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49433_49433_1_LONP2-HIRA_LONP2_chr16_48337216_ENST00000285737_HIRA_chr22_19398301_ENST00000263208_length(transcript)=5647nt_BP=1888nt
AGGCGGGTCTGAGGTTTGGTGACTGCGGGGCAGGCCGGGGGCAGCTGTCTGTCTGGCTCTTTTTGACAGCCCCCAGTGCGAAAGGCTGCC
AGCATGTCATCAGTGAGCCCCATCCAGATCCCCAGTCGCCTCCCGCTGCTGCTCACCCACGAGGGCGTCCTGCTGCCCGGCTCCACCATG
CGCACCAGCGTGGACTCGGCCCGCAACCTGCAGCTGGTGCGGAGCCGCCTTCTGAAGGGCACGTCGCTGCAAAGCACCATCCTGGGCGTC
ATCCCCAACACGCCTGACCCCGCCAGCGACGCGCAGGACCTGCCGCCGCTGCACAGGATTGGCACAGCTGCACTGGCCGTTCAGGTTGTG
GGCAGTAACTGGCCCAAGCCCCACTACACTCTGTTGATTACAGGCCTATGCCGTTTCCAGATTGTACAGGTCTTAAAAGAGAAGCCATAT
CCCATTGCTGAAGTGGAGCAGTTGGACCGACTTGAGGAGTTTCCCAACACCTGTAAAATGAGGGAGGAGCTAGGAGAACTATCAGAGCAG
TTTTACAAATATGCAGTACAATTGGTTGAAATGTTGGATATGTCTGTCCCTGCAGTTGCTAAATTGAGACGTCTTTTAGATAGTCTTCCA
AGGGAAGCTTTACCAGACATCTTGACATCAATTATCCGAACAAGCAACAAAGAGAAACTCCAGATTTTAGATGCTGTGAGCCTAGAGGAG
CGGTTCAAGATGACTATACCACTGCTTGTCAGACAAATTGAAGGCCTGAAATTGCTTCAAAAAACCAGAAAACCCAAGCAAGATGATGAT
AAGAGGGTTATAGCAATACGCCCTATTAGGAGAATTACACATATCTCAGGTACTTTAGAAGATGAAGATGAAGATGAAGATAATGATGAC
ATTGTCATGCTAGAGAAAAAAATACGAACATCTAGTATGCCAGAGCAGGCCCATAAAGTCTGTGTCAAAGAGATAAAGAGACTCAAAAAA
ATGCCTCAGTCAATGCCAGAATATGCTCTGACTAGAAATTATTTGGAACTTATGGTAGAACTTCCTTGGAACAAAAGTACAACTGACCGC
CTGGACATTAGGGCAGCCCGGATTCTTCTGGATAATGACCATTACGCCATGGAAAAATTGAAGAAAAGAGTACTGGAATACTTGGCTGTC
AGACAGCTCAAAAATAACCTGAAGGGCCCAATCCTATGCTTTGTTGGCCCTCCTGGAGTTGGTAAAACAAGTGTGGGAAGATCAGTGGCC
AAGACTCTAGGTCGAGAGTTCCACAGGATTGCACTTGGAGGAGTATGTGATCAGTCTGACATTCGAGGACACAGGCGCACCTATGTTGGC
AGCATGCCTGGTCGCATCATCAACGGCTTGAAGACTGTGGGAGTGAACAACCCAGTGTTCCTATTAGATGAGGTTGACAAACTGGGAAAA
AGTCTACAGGGTGATCCAGCAGCAGCTCTGCTTGAGGTGTTGGATCCTGAACAAAACCATAACTTCACAGATCATTATCTAAATGTGGCC
TTTGACCTTTCTCAAGTTCTTTTTATAGCTACTGCCAACACCACTGCTACCATTCCAGCTGCCTTGTTGGACAGAATGGAGATCATTCAG
GTTCCAGGTTATACACAGGAGGAGAAGATAGAGATTGCCCATAGGCACTTGATCCCCAAGCAGCTGGAACAACATGGGCTGACTCCACAG
CAGATTCAGATACCCCAGGTCACCACTCTTGACATCATCACCAGGTATACCAGAGAGGCAGGGGTTCGTTCTCTGGATAGAAAACTTGGG
GCCATTTGCCGAGCTGTGGCCGTGAAGGTGGCAGAAGGACAGCATAAGGAAGCCAAGTTGGACCGTTCTGATGTGACTGAGAGAGAAGGC
AAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGG
AATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTG
AACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATC
GGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGAT
GTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCTGGAATGCTGTAAAGTTC
CCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAATACATAGCTTCTCAAGCT
GATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATGAGTGTGGAGGAACGACC
CATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCCCATGCCATGAACAACTCAGGCCCCACTGCCCAGATCATC
GAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCTGTGACTGTCGTGAAATTCAACCCAAAAATCTTCAAAAAG
AAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGTGCTGTTGGCAGCAAGGACCGCTCGCTTTCTGTCTGGCTC
ACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCCATCATGGATATTTCCTGGACTCTGAATGGGCTGGGCATC
TTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGATGAGCTTGGCGATCCCCTGAGCGAGGAGGAGAAGAGCCGC
ATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAGCTCTCCACAGCCGTCATTGAGAACCCTGAGATGCTCAAG
TACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACCAGGGAGATGGGCTCAGCCACCTCAGTCGCAGGCGTTGTC
AACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTTGAGACTCGGACAGCAGATGGCCGGAGAAGAATCACGCCT
CTCTGCATAGCACAGCTGGACACTGGGGACTTCTCCACGGCATTCTTTAACAGCATCCCCCTCTCGGGCTCCCTGGCGGGCACCATGCTC
TCTTCTCATAGCAGTCCACAGCTACTGCCACTGGACTCCAGTACCCCTAACTCCTTCGGCGCCTCGAAGCCTTGCACAGAGCCTGTGGTG
GCTGCCAGTGCCAGACCTGCAGGCGATTCTGTCAATAAAGACAGTATGAATGCTACCTCTACTCCTGCTGCATTGTCACCTTCTGTGTTA
ACGACCCCGTCCAAGATCGAACCCATGAAAGCGTTTGACTCCCGGTTCACAGAGCGGTCCAAAGCCACACCAGGTGCTCCTGCCCTGACC
AGCATGACTCCGACAGCTGTGGAAAGGTTAAAAGAGCAGAACCTTGTGAAAGAGCTGAGGCCCCGAGACCTCCTGGAGAGCAGCAGTGAC
AGCGATGAGAAAGTCCCTTTGGCTAAGGCTTCCTCACTGTCCAAGCGAAAACTTGAGCTTGAGGTAGAGACAGTAGAGAAGAAGAAGAAA
GGGCGGCCTCGGAAGGACTCTCGTCTCATGCCTGTGTCTCTGTCTGTCCAGTCTCCAGCTGCCCTAACCGCAGAGAAGGAGGCCATGTGT
CTGTCTGCACCAGCACTTGCACTGAAGCTGCCAATTCCAAGCCCCCAGAGAGCATTCACCCTCCAGGTCAGCTCCGATCCTTCCATGTAC
ATTGAGGTGGAGAATGAAGTGACAGTGGTGGGGGGCGTGAAGCTGAGCCGCCTGAAGTGCAACCGGGAAGGGAAGGAGTGGGAGACGGTA
CTCACCAGCCGGATCCTCACTGCTGCGGGCAGCTGTGACGTGGTGTGTGTCGCCTGTGAAAAAAGGATGCTGTCAGTGTTCTCCACCTGT
GGTCGCCGTCTCCTCTCTCCCATCCTCCTGCCATCCCCGATCTCTACTTTGCATTGCACAGGCTCCTACGTCATGGCGCTCACCGCTGCA
GCCACACTCTCTGTCTGGGATGTTCACAGACAGGTGGTTGTGGTGAAAGAAGAGTCTCTACACTCCATCCTGGCAGGAAGTGATATGACG
GTATCACAGATCTTGCTGACGCAGCATGGAATCCCAGTAATGAACCTGTCCGATGGGAAGGCGTACTGCTTTAATCCGTCACTTTCCACA
TGGAACCTGGTTTCTGACAAGCAGGACTCACTGGCTCAGTGTGCAGACTTTAGGAGCAGCCTGCCATCCCAGGACGCCATGCTGTGCTCA
GGACCGTTAGCCATAATCCAGGGCCGCACCTCCAACTCGGGAAGGCAGGCTGCCCGGCTCTTCTCCGTGCCTCATGTGGTGCAGCAAGAG
ACCACCCTGGCCTACCTAGAGAACCAGGTGGCAGCAGCACTCACCCTGCAGTCCAGCCACGAGTACCGCCATTGGCTCCTCGTCTACGCA
CGGTACCTCGTAAACGAAGGGTTTGAATACCGACTTCGAGAAATATGCAAGGACTTACTGGGTCCGGTTCACTACTCCACTGGAAGCCAG
TGGGAGTCAACAGTAGTGGGTCTGCGGAAGAGGGAGCTGCTGAAGGAGCTGCTACCAGTCATCGGGCAGAACCTCCGATTCCAGCGCCTC
TTCACCGAGTGTCAGGAACAGCTCGACATCCTGAGGGACAAGTAGCCTGCCCCAGCCTGCCCTGGCTGCAGCAAGGGCAGGGCCACACTC
TCGCCGCTGATGACATGCAGGACCGCCTCTCACCTGACCAGGCTGTAGGGGGAGGAGACACTGGCAGGAGATGTGCTGTCCTGCACCAGC
GCCAGCCCAGCTCCCTGGGCAGATGTGCCCTGTGTCCTGGGTCTGACATTGCCTCAGGAGGGGGAAGCTCATCCCTCCCTCCAAGCCCCC
GATGCGGAGCTAGGGCTGGAGCTCTGCCCAGGTGCCCTGGGGCCAGCAAGGCAGTCCCAGGCCTGCCGTCTCCAGCACGGCCCCAAGGTG
GACACTAGCCCCTGCTGCTGCAGGCACCATGCTGCTTCAGCAGTGACGATTGAGCCATTTGTGAGAGAGAATCCGGAAGCGTTAGGTATT
ACAGCAGACTGACCTAAGACCTATGTAAAAGGAAAGCTGTTCCAACACACGGACTATTTTTGTACTAGAATTTGCTAACTTGTAATATTG
AATTTCCTTTGGCCGATAATCAGGATTTCCCTATAAGTCACTTGGACATTGGTCACTTGTAGGAAATTTAAACTCTAATTATGACAGCTA
CACTGAAAAATAATTGTACTGAAATTAACTTGTCTATCTTCATTTGGTTTTAATTTTTAAATGTTTGTAAAAAGAGACTGTTTTGGGGGA

>49433_49433_1_LONP2-HIRA_LONP2_chr16_48337216_ENST00000285737_HIRA_chr22_19398301_ENST00000263208_length(amino acids)=1603AA_BP=598
MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDAQDLPPLHRIGTAALAVQVVG
SNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPR
EALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHISGTLEDEDEDEDNDDI
VMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVR
QLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKS
LQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQ
IQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV
MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTH
VLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLT
CLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKY
QRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLS
SHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMNATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTS
MTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQSPAALTAEKEAMCL
SAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSRLKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCG
RRLLSPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTW
NLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYAR

--------------------------------------------------------------
>49433_49433_2_LONP2-HIRA_LONP2_chr16_48337216_ENST00000285737_HIRA_chr22_19398301_ENST00000340170_length(transcript)=5026nt_BP=1888nt
AGGCGGGTCTGAGGTTTGGTGACTGCGGGGCAGGCCGGGGGCAGCTGTCTGTCTGGCTCTTTTTGACAGCCCCCAGTGCGAAAGGCTGCC
AGCATGTCATCAGTGAGCCCCATCCAGATCCCCAGTCGCCTCCCGCTGCTGCTCACCCACGAGGGCGTCCTGCTGCCCGGCTCCACCATG
CGCACCAGCGTGGACTCGGCCCGCAACCTGCAGCTGGTGCGGAGCCGCCTTCTGAAGGGCACGTCGCTGCAAAGCACCATCCTGGGCGTC
ATCCCCAACACGCCTGACCCCGCCAGCGACGCGCAGGACCTGCCGCCGCTGCACAGGATTGGCACAGCTGCACTGGCCGTTCAGGTTGTG
GGCAGTAACTGGCCCAAGCCCCACTACACTCTGTTGATTACAGGCCTATGCCGTTTCCAGATTGTACAGGTCTTAAAAGAGAAGCCATAT
CCCATTGCTGAAGTGGAGCAGTTGGACCGACTTGAGGAGTTTCCCAACACCTGTAAAATGAGGGAGGAGCTAGGAGAACTATCAGAGCAG
TTTTACAAATATGCAGTACAATTGGTTGAAATGTTGGATATGTCTGTCCCTGCAGTTGCTAAATTGAGACGTCTTTTAGATAGTCTTCCA
AGGGAAGCTTTACCAGACATCTTGACATCAATTATCCGAACAAGCAACAAAGAGAAACTCCAGATTTTAGATGCTGTGAGCCTAGAGGAG
CGGTTCAAGATGACTATACCACTGCTTGTCAGACAAATTGAAGGCCTGAAATTGCTTCAAAAAACCAGAAAACCCAAGCAAGATGATGAT
AAGAGGGTTATAGCAATACGCCCTATTAGGAGAATTACACATATCTCAGGTACTTTAGAAGATGAAGATGAAGATGAAGATAATGATGAC
ATTGTCATGCTAGAGAAAAAAATACGAACATCTAGTATGCCAGAGCAGGCCCATAAAGTCTGTGTCAAAGAGATAAAGAGACTCAAAAAA
ATGCCTCAGTCAATGCCAGAATATGCTCTGACTAGAAATTATTTGGAACTTATGGTAGAACTTCCTTGGAACAAAAGTACAACTGACCGC
CTGGACATTAGGGCAGCCCGGATTCTTCTGGATAATGACCATTACGCCATGGAAAAATTGAAGAAAAGAGTACTGGAATACTTGGCTGTC
AGACAGCTCAAAAATAACCTGAAGGGCCCAATCCTATGCTTTGTTGGCCCTCCTGGAGTTGGTAAAACAAGTGTGGGAAGATCAGTGGCC
AAGACTCTAGGTCGAGAGTTCCACAGGATTGCACTTGGAGGAGTATGTGATCAGTCTGACATTCGAGGACACAGGCGCACCTATGTTGGC
AGCATGCCTGGTCGCATCATCAACGGCTTGAAGACTGTGGGAGTGAACAACCCAGTGTTCCTATTAGATGAGGTTGACAAACTGGGAAAA
AGTCTACAGGGTGATCCAGCAGCAGCTCTGCTTGAGGTGTTGGATCCTGAACAAAACCATAACTTCACAGATCATTATCTAAATGTGGCC
TTTGACCTTTCTCAAGTTCTTTTTATAGCTACTGCCAACACCACTGCTACCATTCCAGCTGCCTTGTTGGACAGAATGGAGATCATTCAG
GTTCCAGGTTATACACAGGAGGAGAAGATAGAGATTGCCCATAGGCACTTGATCCCCAAGCAGCTGGAACAACATGGGCTGACTCCACAG
CAGATTCAGATACCCCAGGTCACCACTCTTGACATCATCACCAGGTATACCAGAGAGGCAGGGGTTCGTTCTCTGGATAGAAAACTTGGG
GCCATTTGCCGAGCTGTGGCCGTGAAGGTGGCAGAAGGACAGCATAAGGAAGCCAAGTTGGACCGTTCTGATGTGACTGAGAGAGAAGGC
AAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTGGGAAGGTTGTGATCTGG
AATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACAATCACTTAGCATGTGTG
AACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGAAGCGGGCTACGTACATC
GGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCCGGAATCATTCAGGCGAT
GTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCTGGAATGCTGTAAAGTTC
CCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAATACATAGCTTCTCAAGCT
GATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATGAGTGTGGAGGAACGACC
CATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCCCATGCCATGAACAACTCAGGCCCCACTGCCCAGATCATC
GAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCTGTGACTGTCGTGAAATTCAACCCAAAAATCTTCAAAAAG
AAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGTGCTGTTGGCAGCAAGGACCGCTCGCTTTCTGTCTGGCTC
ACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCCATCATGGATATTTCCTGGACTCTGAATGGGCTGGGCATC
TTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGATGAGCTTGGCGATCCCCTGAGCGAGGAGGAGAAGAGCCGC
ATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAGCTCTCCACAGCCGTCATTGAGAACCCTGAGATGCTCAAG
TACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACCAGGGAGATGGGCTCAGCCACCTCAGTCGCAGGCGTTGTC
AACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTTGAGACTCGGACAGCAGATGGCCGGAGAAGAATCACGCCT
CTCTGCATAGCACAGCTGGACACTGGGGACTTCTCCACGGCATTCTTTAACAGCATCCCCCTCTCGGGCTCCCTGGCGGGCACCATGCTC
TCTTCTCATAGCAGTCCACAGCTACTGCCACTGGACTCCAGTACCCCTAACTCCTTCGGCGCCTCGAAGCCTTGCACAGAGCCTGTGGTG
GCTGCCAGTGCCAGACCTGCAGGCGATTCTGTCAATAAAGACAGTATGAATGCTACCTCTACTCCTGCTGCATTGTCACCTTCTGTGTTA
ACGACCCCGTCCAAGATCGAACCCATGAAAGCGTTTGACTCCCGGTTCACAGAGCGGTCCAAAGCCACACCAGGTGCTCCTGCCCTGACC
AGCATGACTCCGACAGCTGTGGAAAGGGATGTTCACAGACAGGTGGTTGTGGTGAAAGAAGAGTCTCTACACTCCATCCTGGCAGGAAGT
GATATGACGGTATCACAGATCTTGCTGACGCAGCATGGAATCCCAGTAATGAACCTGTCCGATGGGAAGGCGTACTGCTTTAATCCGTCA
CTTTCCACATGGAACCTGGTTTCTGACAAGCAGGACTCACTGGCTCAGTGTGCAGACTTTAGGAGCAGCCTGCCATCCCAGGACGCCATG
CTGTGCTCAGGACCGTTAGCCATAATCCAGGGCCGCACCTCCAACTCGGGAAGGCAGGCTGCCCGGCTCTTCTCCGTGCCTCATGTGGTG
CAGCAAGAGACCACCCTGGCCTACCTAGAGAACCAGGTGGCAGCAGCACTCACCCTGCAGTCCAGCCACGAGTACCGCCATTGGCTCCTC
GTCTACGCACGGTACCTCGTAAACGAAGGGTTTGAATACCGACTTCGAGAAATATGCAAGGACTTACTGGGTCCGGTTCACTACTCCACT
GGAAGCCAGTGGGAGTCAACAGTAGTGGGTCTGCGGAAGAGGGAGCTGCTGAAGGAGCTGCTACCAGTCATCGGGCAGAACCTCCGATTC
CAGCGCCTCTTCACCGAGTGTCAGGAACAGCTCGACATCCTGAGGGACAAGTAGCCTGCCCCAGCCTGCCCTGGCTGCAGCAAGGGCAGG
GCCACACTCTCGCCGCTGATGACATGCAGGACCGCCTCTCACCTGACCAGGCTGTAGGGGGAGGAGACACTGGCAGGAGATGTGCTGTCC
TGCACCAGCGCCAGCCCAGCTCCCTGGGCAGATGTGCCCTGTGTCCTGGGTCTGACATTGCCTCAGGAGGGGGAAGCTCATCCCTCCCTC
CAAGCCCCCGATGCGGAGCTAGGGCTGGAGCTCTGCCCAGGTGCCCTGGGGCCAGCAAGGCAGTCCCAGGCCTGCCGTCTCCAGCACGGC
CCCAAGGTGGACACTAGCCCCTGCTGCTGCAGGCACCATGCTGCTTCAGCAGTGACGATTGAGCCATTTGTGAGAGAGAATCCGGAAGCG
TTAGGTATTACAGCAGACTGACCTAAGACCTATGTAAAAGGAAAGCTGTTCCAACACACGGACTATTTTTGTACTAGAATTTGCTAACTT
GTAATATTGAATTTCCTTTGGCCGATAATCAGGATTTCCCTATAAGTCACTTGGACATTGGTCACTTGTAGGAAATTTAAACTCTAATTA
TGACAGCTACACTGAAAAATAATTGTACTGAAATTAACTTGTCTATCTTCATTTGGTTTTAATTTTTAAATGTTTGTAAAAAGAGACTGT

>49433_49433_2_LONP2-HIRA_LONP2_chr16_48337216_ENST00000285737_HIRA_chr22_19398301_ENST00000340170_length(amino acids)=1396AA_BP=598
MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDAQDLPPLHRIGTAALAVQVVG
SNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPR
EALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRITHISGTLEDEDEDEDNDDI
VMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVR
QLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKS
LQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQ
IQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDV
MDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTH
VLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLT
CLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKY
QRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLS
SHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMNATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTS
MTPTAVERDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAML
CSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICKDLLGPVHYSTG

--------------------------------------------------------------
>49433_49433_3_LONP2-HIRA_LONP2_chr16_48337216_ENST00000535754_HIRA_chr22_19398301_ENST00000263208_length(transcript)=5478nt_BP=1719nt
GGGGCAGCTGTCTGTCTGGCTCTTTTTGACAGCCCCCAGTGCGAAAGGCTGCCAGCATGTCATCAGTGAGCCCCATCCAGATCCCCAGTC
GCCTCCCGCTGCTGCTCACCCACGAGGGCGTCCTGCTGCCCGGCTCCACCATGCGCACCAGCGTGGACTCGGCCCGCAACCTGCAGCTGG
TGCGGAGCCGCCTTCTGAAGGGCACGTCGCTGCAAAGCACCATCCTGGGCGTCATCCCCAACACGCCTGACCCCGCCAGCGACGCGCAGG
ACCTGCCGCCGCTGCACAGGATTGGCACAGCTGCACTGGCCGTTCAGGTTGTGGGCAGTAACTGGCCCAAGCCCCACTACACTCTGTTGA
TTACAGGCCTATGCCGTTTCCAGATTGTACAGGTCTTAAAAGAGAAGCCATATCCCATTGCTGAAGTGGAGCAGTTGGACCGACTTGAGG
AGTTTCCCAACACCTGTAAAATGAGGGAGGAGCTAGGAGAACTATCAGAGCAGTTTTACAAATATGCAGTACAAATTTTAGATGCTGTGA
GCCTAGAGGAGCGGTTCAAGATGACTATACCACTGCTTGTCAGACAAATTGAAGGCCTGAAATTGCTTCAAAAAACCAGAAAACCCAAGC
AAGATGATGATAAGAGGGTTATAGCAATACGCCCTATTAGGAGAATTACACATATCTCAGGTACTTTAGAAGATGAAGATGAAGATGAAG
ATAATGATGACATTGTCATGCTAGAGAAAAAAATACGAACATCTAGTATGCCAGAGCAGGCCCATAAAGTCTGTGTCAAAGAGATAAAGA
GACTCAAAAAAATGCCTCAGTCAATGCCAGAATATGCTCTGACTAGAAATTATTTGGAACTTATGGTAGAACTTCCTTGGAACAAAAGTA
CAACTGACCGCCTGGACATTAGGGCAGCCCGGATTCTTCTGGATAATGACCATTACGCCATGGAAAAATTGAAGAAAAGAGTACTGGAAT
ACTTGGCTGTCAGACAGCTCAAAAATAACCTGAAGGGCCCAATCCTATGCTTTGTTGGCCCTCCTGGAGTTGGTAAAACAAGTGTGGGAA
GATCAGTGGCCAAGACTCTAGGTCGAGAGTTCCACAGGATTGCACTTGGAGGAGTATGTGATCAGTCTGACATTCGAGGACACAGGCGCA
CCTATGTTGGCAGCATGCCTGGTCGCATCATCAACGGCTTGAAGACTGTGGGAGTGAACAACCCAGTGTTCCTATTAGATGAGGTTGACA
AACTGGGAAAAAGTCTACAGGGTGATCCAGCAGCAGCTCTGCTTGAGGTGTTGGATCCTGAACAAAACCATAACTTCACAGATCATTATC
TAAATGTGGCCTTTGACCTTTCTCAAGTTCTTTTTATAGCTACTGCCAACACCACTGCTACCATTCCAGCTGCCTTGTTGGACAGAATGG
AGATCATTCAGGTTCCAGGTTATACACAGGAGGAGAAGATAGAGATTGCCCATAGGCACTTGATCCCCAAGCAGCTGGAACAACATGGGC
TGACTCCACAGCAGATTCAGATACCCCAGGTCACCACTCTTGACATCATCACCAGGTATACCAGAGAGGCAGGGGTTCGTTCTCTGGATA
GAAAACTTGGGGCCATTTGCCGAGCTGTGGCCGTGAAGGTGGCAGAAGGACAGCATAAGGAAGCCAAGTTGGACCGTTCTGATGTGACTG
AGAGAGAAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTGGGAAGG
TTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACAATCACT
TAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGAAGCGGG
CTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCCGGAATC
ATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCTGGAATG
CTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAATACATAG
CTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATGAGTGTG
GAGGAACGACCCATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCCCATGCCATGAACAACTCAGGCCCCACTG
CCCAGATCATCGAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCTGTGACTGTCGTGAAATTCAACCCAAAAA
TCTTCAAAAAGAAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGTGCTGTTGGCAGCAAGGACCGCTCGCTTT
CTGTCTGGCTCACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCCATCATGGATATTTCCTGGACTCTGAATG
GGCTGGGCATCTTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGATGAGCTTGGCGATCCCCTGAGCGAGGAGG
AGAAGAGCCGCATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAGCTCTCCACAGCCGTCATTGAGAACCCTG
AGATGCTCAAGTACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACCAGGGAGATGGGCTCAGCCACCTCAGTCG
CAGGCGTTGTCAACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTTGAGACTCGGACAGCAGATGGCCGGAGAA
GAATCACGCCTCTCTGCATAGCACAGCTGGACACTGGGGACTTCTCCACGGCATTCTTTAACAGCATCCCCCTCTCGGGCTCCCTGGCGG
GCACCATGCTCTCTTCTCATAGCAGTCCACAGCTACTGCCACTGGACTCCAGTACCCCTAACTCCTTCGGCGCCTCGAAGCCTTGCACAG
AGCCTGTGGTGGCTGCCAGTGCCAGACCTGCAGGCGATTCTGTCAATAAAGACAGTATGAATGCTACCTCTACTCCTGCTGCATTGTCAC
CTTCTGTGTTAACGACCCCGTCCAAGATCGAACCCATGAAAGCGTTTGACTCCCGGTTCACAGAGCGGTCCAAAGCCACACCAGGTGCTC
CTGCCCTGACCAGCATGACTCCGACAGCTGTGGAAAGGTTAAAAGAGCAGAACCTTGTGAAAGAGCTGAGGCCCCGAGACCTCCTGGAGA
GCAGCAGTGACAGCGATGAGAAAGTCCCTTTGGCTAAGGCTTCCTCACTGTCCAAGCGAAAACTTGAGCTTGAGGTAGAGACAGTAGAGA
AGAAGAAGAAAGGGCGGCCTCGGAAGGACTCTCGTCTCATGCCTGTGTCTCTGTCTGTCCAGTCTCCAGCTGCCCTAACCGCAGAGAAGG
AGGCCATGTGTCTGTCTGCACCAGCACTTGCACTGAAGCTGCCAATTCCAAGCCCCCAGAGAGCATTCACCCTCCAGGTCAGCTCCGATC
CTTCCATGTACATTGAGGTGGAGAATGAAGTGACAGTGGTGGGGGGCGTGAAGCTGAGCCGCCTGAAGTGCAACCGGGAAGGGAAGGAGT
GGGAGACGGTACTCACCAGCCGGATCCTCACTGCTGCGGGCAGCTGTGACGTGGTGTGTGTCGCCTGTGAAAAAAGGATGCTGTCAGTGT
TCTCCACCTGTGGTCGCCGTCTCCTCTCTCCCATCCTCCTGCCATCCCCGATCTCTACTTTGCATTGCACAGGCTCCTACGTCATGGCGC
TCACCGCTGCAGCCACACTCTCTGTCTGGGATGTTCACAGACAGGTGGTTGTGGTGAAAGAAGAGTCTCTACACTCCATCCTGGCAGGAA
GTGATATGACGGTATCACAGATCTTGCTGACGCAGCATGGAATCCCAGTAATGAACCTGTCCGATGGGAAGGCGTACTGCTTTAATCCGT
CACTTTCCACATGGAACCTGGTTTCTGACAAGCAGGACTCACTGGCTCAGTGTGCAGACTTTAGGAGCAGCCTGCCATCCCAGGACGCCA
TGCTGTGCTCAGGACCGTTAGCCATAATCCAGGGCCGCACCTCCAACTCGGGAAGGCAGGCTGCCCGGCTCTTCTCCGTGCCTCATGTGG
TGCAGCAAGAGACCACCCTGGCCTACCTAGAGAACCAGGTGGCAGCAGCACTCACCCTGCAGTCCAGCCACGAGTACCGCCATTGGCTCC
TCGTCTACGCACGGTACCTCGTAAACGAAGGGTTTGAATACCGACTTCGAGAAATATGCAAGGACTTACTGGGTCCGGTTCACTACTCCA
CTGGAAGCCAGTGGGAGTCAACAGTAGTGGGTCTGCGGAAGAGGGAGCTGCTGAAGGAGCTGCTACCAGTCATCGGGCAGAACCTCCGAT
TCCAGCGCCTCTTCACCGAGTGTCAGGAACAGCTCGACATCCTGAGGGACAAGTAGCCTGCCCCAGCCTGCCCTGGCTGCAGCAAGGGCA
GGGCCACACTCTCGCCGCTGATGACATGCAGGACCGCCTCTCACCTGACCAGGCTGTAGGGGGAGGAGACACTGGCAGGAGATGTGCTGT
CCTGCACCAGCGCCAGCCCAGCTCCCTGGGCAGATGTGCCCTGTGTCCTGGGTCTGACATTGCCTCAGGAGGGGGAAGCTCATCCCTCCC
TCCAAGCCCCCGATGCGGAGCTAGGGCTGGAGCTCTGCCCAGGTGCCCTGGGGCCAGCAAGGCAGTCCCAGGCCTGCCGTCTCCAGCACG
GCCCCAAGGTGGACACTAGCCCCTGCTGCTGCAGGCACCATGCTGCTTCAGCAGTGACGATTGAGCCATTTGTGAGAGAGAATCCGGAAG
CGTTAGGTATTACAGCAGACTGACCTAAGACCTATGTAAAAGGAAAGCTGTTCCAACACACGGACTATTTTTGTACTAGAATTTGCTAAC
TTGTAATATTGAATTTCCTTTGGCCGATAATCAGGATTTCCCTATAAGTCACTTGGACATTGGTCACTTGTAGGAAATTTAAACTCTAAT
TATGACAGCTACACTGAAAAATAATTGTACTGAAATTAACTTGTCTATCTTCATTTGGTTTTAATTTTTAAATGTTTGTAAAAAGAGACT

>49433_49433_3_LONP2-HIRA_LONP2_chr16_48337216_ENST00000535754_HIRA_chr22_19398301_ENST00000263208_length(amino acids)=1559AA_BP=554
MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDAQDLPPLHRIGTAALAVQVVG
SNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQILDAVSLEERFKMTIPLLVRQIEG
LKLLQKTRKPKQDDDKRVIAIRPIRRITHISGTLEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYL
ELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGV
CDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTT
ATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQH
KEAKLDRSDVTEREGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASG
GDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVK
GLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHR
KAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFS
QDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKK
QVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDS
MNATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKASSLSK
RKLELEVETVEKKKKGRPRKDSRLMPVSLSVQSPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKL
SRLKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTLHCTGSYVMALTAAATLSVWDVHRQVVVV
KEESLHSILAGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGR
QAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICKDLLGPVHYSTGSQWESTVVGLRKRELLK

--------------------------------------------------------------
>49433_49433_4_LONP2-HIRA_LONP2_chr16_48337216_ENST00000535754_HIRA_chr22_19398301_ENST00000340170_length(transcript)=4857nt_BP=1719nt
GGGGCAGCTGTCTGTCTGGCTCTTTTTGACAGCCCCCAGTGCGAAAGGCTGCCAGCATGTCATCAGTGAGCCCCATCCAGATCCCCAGTC
GCCTCCCGCTGCTGCTCACCCACGAGGGCGTCCTGCTGCCCGGCTCCACCATGCGCACCAGCGTGGACTCGGCCCGCAACCTGCAGCTGG
TGCGGAGCCGCCTTCTGAAGGGCACGTCGCTGCAAAGCACCATCCTGGGCGTCATCCCCAACACGCCTGACCCCGCCAGCGACGCGCAGG
ACCTGCCGCCGCTGCACAGGATTGGCACAGCTGCACTGGCCGTTCAGGTTGTGGGCAGTAACTGGCCCAAGCCCCACTACACTCTGTTGA
TTACAGGCCTATGCCGTTTCCAGATTGTACAGGTCTTAAAAGAGAAGCCATATCCCATTGCTGAAGTGGAGCAGTTGGACCGACTTGAGG
AGTTTCCCAACACCTGTAAAATGAGGGAGGAGCTAGGAGAACTATCAGAGCAGTTTTACAAATATGCAGTACAAATTTTAGATGCTGTGA
GCCTAGAGGAGCGGTTCAAGATGACTATACCACTGCTTGTCAGACAAATTGAAGGCCTGAAATTGCTTCAAAAAACCAGAAAACCCAAGC
AAGATGATGATAAGAGGGTTATAGCAATACGCCCTATTAGGAGAATTACACATATCTCAGGTACTTTAGAAGATGAAGATGAAGATGAAG
ATAATGATGACATTGTCATGCTAGAGAAAAAAATACGAACATCTAGTATGCCAGAGCAGGCCCATAAAGTCTGTGTCAAAGAGATAAAGA
GACTCAAAAAAATGCCTCAGTCAATGCCAGAATATGCTCTGACTAGAAATTATTTGGAACTTATGGTAGAACTTCCTTGGAACAAAAGTA
CAACTGACCGCCTGGACATTAGGGCAGCCCGGATTCTTCTGGATAATGACCATTACGCCATGGAAAAATTGAAGAAAAGAGTACTGGAAT
ACTTGGCTGTCAGACAGCTCAAAAATAACCTGAAGGGCCCAATCCTATGCTTTGTTGGCCCTCCTGGAGTTGGTAAAACAAGTGTGGGAA
GATCAGTGGCCAAGACTCTAGGTCGAGAGTTCCACAGGATTGCACTTGGAGGAGTATGTGATCAGTCTGACATTCGAGGACACAGGCGCA
CCTATGTTGGCAGCATGCCTGGTCGCATCATCAACGGCTTGAAGACTGTGGGAGTGAACAACCCAGTGTTCCTATTAGATGAGGTTGACA
AACTGGGAAAAAGTCTACAGGGTGATCCAGCAGCAGCTCTGCTTGAGGTGTTGGATCCTGAACAAAACCATAACTTCACAGATCATTATC
TAAATGTGGCCTTTGACCTTTCTCAAGTTCTTTTTATAGCTACTGCCAACACCACTGCTACCATTCCAGCTGCCTTGTTGGACAGAATGG
AGATCATTCAGGTTCCAGGTTATACACAGGAGGAGAAGATAGAGATTGCCCATAGGCACTTGATCCCCAAGCAGCTGGAACAACATGGGC
TGACTCCACAGCAGATTCAGATACCCCAGGTCACCACTCTTGACATCATCACCAGGTATACCAGAGAGGCAGGGGTTCGTTCTCTGGATA
GAAAACTTGGGGCCATTTGCCGAGCTGTGGCCGTGAAGGTGGCAGAAGGACAGCATAAGGAAGCCAAGTTGGACCGTTCTGATGTGACTG
AGAGAGAAGGCAAGCCGATTTTTTCAGTTGATATTCACCCTGACGGGACCAAGTTCGCAACTGGAGGACAAGGGCAGGATTCTGGGAAGG
TTGTGATCTGGAATATGTCTCCAGTCCTCCAGGAGGATGACGAGAAGGATGAAAATATTCCCAAGATGCTTTGCCAGATGGACAATCACT
TAGCATGTGTGAACTGTGTGCGGTGGTCAAACAGTGGGATGTATTTAGCTTCTGGGGGAGATGACAAACTGATTATGGTGTGGAAGCGGG
CTACGTACATCGGCCCCAGCACCGTGTTCGGCTCCAGTGGTAAGCTTGCCAATGTGGAGCAGTGGCGGTGTGTCTCTATCCTCCGGAATC
ATTCAGGCGATGTGATGGATGTAGCATGGTCTCCCCACGATGCCTGGCTAGCCTCATGCAGCGTGGATAACACTGTCGTCATCTGGAATG
CTGTAAAGTTCCCAGAAATTCTAGCTACTCTGAGAGGTCATTCTGGCTTGGTCAAAGGGTTGACATGGGACCCTGTTGGTAAATACATAG
CTTCTCAAGCTGATGACCGCAGCCTAAAGGTGTGGAGGACGCTGGACTGGCAGTTGGAGACCAGCATCACCAAGCCTTTTGATGAGTGTG
GAGGAACGACCCATGTGTTGCGGCTCAGCTGGTCACCTGATGGGCATTACCTGGTGTCTGCCCATGCCATGAACAACTCAGGCCCCACTG
CCCAGATCATCGAACGGGAGGGATGGAAGACCAACATGGACTTTGTTGGGCACCGGAAAGCTGTGACTGTCGTGAAATTCAACCCAAAAA
TCTTCAAAAAGAAGCAGAAGAATGGGAGTTCTGCGAAGCCTAGCTGCCCGTACTGCTGCTGTGCTGTTGGCAGCAAGGACCGCTCGCTTT
CTGTCTGGCTCACATGTCTGAAACGGCCGCTGGTGGTCATCCATGAACTGTTTGACAAATCCATCATGGATATTTCCTGGACTCTGAATG
GGCTGGGCATCTTGGTATGCTCTATGGACGGCTCTGTGGCATTCCTCGACTTCTCCCAGGATGAGCTTGGCGATCCCCTGAGCGAGGAGG
AGAAGAGCCGCATTCACCAGTCCACCTATGGCAAGAGCCTAGCCATCATGACCGAGGCCCAGCTCTCCACAGCCGTCATTGAGAACCCTG
AGATGCTCAAGTACCAGCGAAGGCAGCAGCAGCAGCAGCTGGACCAGAAGAGTGCTGCGACCAGGGAGATGGGCTCAGCCACCTCAGTCG
CAGGCGTTGTCAACGGGGAGAGTCTTGAAGATATCAGGAAGAATCTTTTGAAGAAACAAGTTGAGACTCGGACAGCAGATGGCCGGAGAA
GAATCACGCCTCTCTGCATAGCACAGCTGGACACTGGGGACTTCTCCACGGCATTCTTTAACAGCATCCCCCTCTCGGGCTCCCTGGCGG
GCACCATGCTCTCTTCTCATAGCAGTCCACAGCTACTGCCACTGGACTCCAGTACCCCTAACTCCTTCGGCGCCTCGAAGCCTTGCACAG
AGCCTGTGGTGGCTGCCAGTGCCAGACCTGCAGGCGATTCTGTCAATAAAGACAGTATGAATGCTACCTCTACTCCTGCTGCATTGTCAC
CTTCTGTGTTAACGACCCCGTCCAAGATCGAACCCATGAAAGCGTTTGACTCCCGGTTCACAGAGCGGTCCAAAGCCACACCAGGTGCTC
CTGCCCTGACCAGCATGACTCCGACAGCTGTGGAAAGGGATGTTCACAGACAGGTGGTTGTGGTGAAAGAAGAGTCTCTACACTCCATCC
TGGCAGGAAGTGATATGACGGTATCACAGATCTTGCTGACGCAGCATGGAATCCCAGTAATGAACCTGTCCGATGGGAAGGCGTACTGCT
TTAATCCGTCACTTTCCACATGGAACCTGGTTTCTGACAAGCAGGACTCACTGGCTCAGTGTGCAGACTTTAGGAGCAGCCTGCCATCCC
AGGACGCCATGCTGTGCTCAGGACCGTTAGCCATAATCCAGGGCCGCACCTCCAACTCGGGAAGGCAGGCTGCCCGGCTCTTCTCCGTGC
CTCATGTGGTGCAGCAAGAGACCACCCTGGCCTACCTAGAGAACCAGGTGGCAGCAGCACTCACCCTGCAGTCCAGCCACGAGTACCGCC
ATTGGCTCCTCGTCTACGCACGGTACCTCGTAAACGAAGGGTTTGAATACCGACTTCGAGAAATATGCAAGGACTTACTGGGTCCGGTTC
ACTACTCCACTGGAAGCCAGTGGGAGTCAACAGTAGTGGGTCTGCGGAAGAGGGAGCTGCTGAAGGAGCTGCTACCAGTCATCGGGCAGA
ACCTCCGATTCCAGCGCCTCTTCACCGAGTGTCAGGAACAGCTCGACATCCTGAGGGACAAGTAGCCTGCCCCAGCCTGCCCTGGCTGCA
GCAAGGGCAGGGCCACACTCTCGCCGCTGATGACATGCAGGACCGCCTCTCACCTGACCAGGCTGTAGGGGGAGGAGACACTGGCAGGAG
ATGTGCTGTCCTGCACCAGCGCCAGCCCAGCTCCCTGGGCAGATGTGCCCTGTGTCCTGGGTCTGACATTGCCTCAGGAGGGGGAAGCTC
ATCCCTCCCTCCAAGCCCCCGATGCGGAGCTAGGGCTGGAGCTCTGCCCAGGTGCCCTGGGGCCAGCAAGGCAGTCCCAGGCCTGCCGTC
TCCAGCACGGCCCCAAGGTGGACACTAGCCCCTGCTGCTGCAGGCACCATGCTGCTTCAGCAGTGACGATTGAGCCATTTGTGAGAGAGA
ATCCGGAAGCGTTAGGTATTACAGCAGACTGACCTAAGACCTATGTAAAAGGAAAGCTGTTCCAACACACGGACTATTTTTGTACTAGAA
TTTGCTAACTTGTAATATTGAATTTCCTTTGGCCGATAATCAGGATTTCCCTATAAGTCACTTGGACATTGGTCACTTGTAGGAAATTTA
AACTCTAATTATGACAGCTACACTGAAAAATAATTGTACTGAAATTAACTTGTCTATCTTCATTTGGTTTTAATTTTTAAATGTTTGTAA

>49433_49433_4_LONP2-HIRA_LONP2_chr16_48337216_ENST00000535754_HIRA_chr22_19398301_ENST00000340170_length(amino acids)=1352AA_BP=554
MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVIPNTPDPASDAQDLPPLHRIGTAALAVQVVG
SNWPKPHYTLLITGLCRFQIVQVLKEKPYPIAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQILDAVSLEERFKMTIPLLVRQIEG
LKLLQKTRKPKQDDDKRVIAIRPIRRITHISGTLEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYL
ELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGV
CDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTT
ATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQH
KEAKLDRSDVTEREGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASG
GDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVK
GLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHR
KAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFS
QDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKK
QVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDS
MNATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIP
VMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAA
ALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICKDLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILR

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Fusion Gene PPI Analysis for LONP2-HIRA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025421_47912.3333333333333341018.0ASF1A
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021421_47912.333333333333334811.0ASF1A
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025421_72912.3333333333333341018.0CCNA1
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021421_72912.333333333333334811.0CCNA1
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025593_82612.3333333333333341018.0histone H2B
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021593_82612.333333333333334811.0histone H2B
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025738_101712.3333333333333341018.0histone H4
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021738_101712.333333333333334811.0histone H4
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025594_73912.3333333333333341018.0PAX3
TgeneHIRAchr16:48337216chr22:19398301ENST00000263208025740_82812.3333333333333341018.0PAX3
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021594_73912.333333333333334811.0PAX3
TgeneHIRAchr16:48337216chr22:19398301ENST00000340170021740_82812.333333333333334811.0PAX3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LONP2-HIRA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LONP2-HIRA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource