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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LPCAT2-CACTIN (FusionGDB2 ID:49498)

Fusion Gene Summary for LPCAT2-CACTIN

check button Fusion gene summary
Fusion gene informationFusion gene name: LPCAT2-CACTIN
Fusion gene ID: 49498
HgeneTgene
Gene symbol

LPCAT2

CACTIN

Gene ID

54947

58509

Gene namelysophosphatidylcholine acyltransferase 2cactin, spliceosome C complex subunit
SynonymsAGPAT11|AYTL1|LysoPAFATC19orf29|NY-REN-24|fSAPc
Cytomap

16q12.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionlysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2cactinNY REN 24 antigenfunctional spliceosome-associated protein crenal carcinoma antigen NY-REN-24
Modification date2020031320200313
UniProtAcc

Q7L5N7

C19orf29,CACTIN

Ensembl transtripts involved in fusion geneENST00000262134, ENST00000565056, 
ENST00000221899, ENST00000248420, 
ENST00000429344, 
Fusion gene scores* DoF score6 X 7 X 4=1682 X 2 X 2=8
# samples 72
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: LPCAT2 [Title/Abstract] AND CACTIN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPCAT2(55571544)-CACTIN(3620270), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLPCAT2

GO:0036151

phosphatidylcholine acyl-chain remodeling

21498505

TgeneCACTIN

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20829348

TgeneCACTIN

GO:0032717

negative regulation of interleukin-8 production

20829348

TgeneCACTIN

GO:0032720

negative regulation of tumor necrosis factor production

20829348

TgeneCACTIN

GO:0034122

negative regulation of toll-like receptor signaling pathway

20829348

TgeneCACTIN

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

26363554

TgeneCACTIN

GO:0071222

cellular response to lipopolysaccharide

20829348

TgeneCACTIN

GO:0071347

cellular response to interleukin-1

20829348

TgeneCACTIN

GO:0071356

cellular response to tumor necrosis factor

20829348


check buttonFusion gene breakpoints across LPCAT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACTIN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1XL-01ALPCAT2chr16

55571544

+CACTINchr19

3620270

-


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Fusion Gene ORF analysis for LPCAT2-CACTIN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262134ENST00000221899LPCAT2chr16

55571544

+CACTINchr19

3620270

-
In-frameENST00000262134ENST00000248420LPCAT2chr16

55571544

+CACTINchr19

3620270

-
In-frameENST00000262134ENST00000429344LPCAT2chr16

55571544

+CACTINchr19

3620270

-
intron-3CDSENST00000565056ENST00000221899LPCAT2chr16

55571544

+CACTINchr19

3620270

-
intron-3CDSENST00000565056ENST00000248420LPCAT2chr16

55571544

+CACTINchr19

3620270

-
intron-3CDSENST00000565056ENST00000429344LPCAT2chr16

55571544

+CACTINchr19

3620270

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262134LPCAT2chr1655571544+ENST00000429344CACTINchr193620270-385710361332574813
ENST00000262134LPCAT2chr1655571544+ENST00000248420CACTINchr193620270-291410361332574813
ENST00000262134LPCAT2chr1655571544+ENST00000221899CACTINchr193620270-310610361333105991

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262134ENST00000429344LPCAT2chr1655571544+CACTINchr193620270-0.0067813390.9932187
ENST00000262134ENST00000248420LPCAT2chr1655571544+CACTINchr193620270-0.0072694230.99273056
ENST00000262134ENST00000221899LPCAT2chr1655571544+CACTINchr193620270-0.003549820.9964502

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Fusion Genomic Features for LPCAT2-CACTIN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LPCAT2-CACTIN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:55571544/chr19:3620270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPCAT2

Q7L5N7

CACTIN

C19orf29,CACTIN

FUNCTION: Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). {ECO:0000250|UniProtKB:Q8BYI6, ECO:0000269|PubMed:17182612, ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505, ECO:0000269|PubMed:25491198}.758

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+814146_151284545.0MotifHXXXXD motif
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+814220_223284545.0MotifNote=EGTC motif
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+8141_57284545.0Topological domainCytoplasmic
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+81458_78284545.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+814404_415284545.0Calcium binding1
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+814441_452284545.0Calcium binding2
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+814391_426284545.0DomainEF-hand 1
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+814428_463284545.0DomainEF-hand 2
HgeneLPCAT2chr16:55571544chr19:3620270ENST00000262134+81479_544284545.0Topological domainLumenal
TgeneCACTINchr16:55571544chr19:3620270ENST00000248420211135_185246804.0Coiled coilOntology_term=ECO:0000255
TgeneCACTINchr16:55571544chr19:3620270ENST00000248420211225_277246804.0Coiled coilOntology_term=ECO:0000255
TgeneCACTINchr16:55571544chr19:3620270ENST00000429344210135_185246759.0Coiled coilOntology_term=ECO:0000255
TgeneCACTINchr16:55571544chr19:3620270ENST00000429344210225_277246759.0Coiled coilOntology_term=ECO:0000255
TgeneCACTINchr16:55571544chr19:3620270ENST00000248420211101_107246804.0Compositional biasNote=Poly-Arg
TgeneCACTINchr16:55571544chr19:3620270ENST00000248420211129_133246804.0Compositional biasNote=Poly-Ala
TgeneCACTINchr16:55571544chr19:3620270ENST00000429344210101_107246759.0Compositional biasNote=Poly-Arg
TgeneCACTINchr16:55571544chr19:3620270ENST00000429344210129_133246759.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for LPCAT2-CACTIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49498_49498_1_LPCAT2-CACTIN_LPCAT2_chr16_55571544_ENST00000262134_CACTIN_chr19_3620270_ENST00000221899_length(transcript)=3106nt_BP=1036nt
AGAGCCTGGGGCGTGTCACAGCCGAAGGGGCAGGGCGGCAGCAGCAGGCGTCTAAGTAACTTCAGCGCCTGCGCAGAGGCTCCCCAGCGT
CGCCCTAGGCTGGGACTCTAGTAGGTCTTCGGCTCAGTTTTGGCTGCAGCGCCCGCGTAGATCGCTTCGGCCGGGTTCTACGCCCGGCTC
AACTATGAGCCGGTGCGCCCAGGCGGCGGAAGTGGCGGCCACAGTGCCAGGTGCCGGCGTCGGGAACGTGGGGCTGCGGCCGCCCATGGT
GCCCCGTCAGGCGTCCTTCTTCCCGCCGCCGGTGCCGAACCCCTTCGTGCAGCAGACGCAGATCGGCTCCGCGAGGCGGGTCCAGATTGT
CCTTCTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCATGGCCATTTGCTGCAATTTCAACAGT
ATGCTGTCCTGAAAAGCTGACCCACCCAATAACTGGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGTCGTGCTATGTT
CTTTTCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTTTTTGTTGCTGCCCCTCATTCAACATT
CTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTACCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATTGGCAGACTGTT
ACGGGCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAATGAAATAATAAAGCGAACAACATCAGG
AGGAGAATGGCCCCAGATACTAGTTTTCCCAGAAGGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGAGCCTTCATTCC
AGGAGTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACATGGCAAGGATATACATTCATTCAGCT
TTGTATGCTTACTTTCTGCCAGCTCTTCACAAAGGTAGAAGTTGAGGTGAAGCAGCTGCGGCTGGAGCGGGAGCGGGAGAAGGCCATGCG
CGAGCAGGAGCTGGAGATGCTGCAGCGCGAGAAGGAGGCAGAGCACTTCAAGACATGGGAGGAGCAGGAGGACAACTTCCACCTCCAGCA
GGCCAAGCTGCGTTCCAAGATCCGCATCCGGGACGGGCGGGCCAAGCCCATCGACCTGCTGGCCAAGTACATCAGCGCTGAGGATGACGA
TCTGGCCGTGGAGATGCATGAGCCCTACACGTTCCTCAACGGCCTCACCGTGGCCGACATGGAGGACCTGCTGGAGGATATCCAGGTCTA
CATGGAGCTGGAGCAGGGCAAGAACGCCGACTTCTGGCGGGACATGACCACCATCACCGAGGACGAGATCTCCAAGCTCCGCAAGCTGGA
GGCCTCGGGCAAGGGGCCAGGTGAGCGCCGCGAGGGGGTCAACGCCTCCGTCAGCTCTGATGTGCAGTCGGTGTTCAAGGGGAAGACATA
CAACCAGCTGCAGGTCATCTTCCAGGGCATCGAGGGCAAAATCCGCGCTGGTGGCCCCAACCTGGACATGGGCTACTGGGAGAGCCTCCT
GCAGCAGCTTCGTGCCCACATGGCACGGGCCCGGCTGCGTGAGCGCCACCAGGACGTGCTGCGGCAGAAGCTGTACAAACTGAAGCAGGA
GCAGGGCGTGGAGAGCGAGCCGCTGTTCCCCATCCTCAAGCAGGAGCCCCAGTCCCCCAGCCGCAGCCTGGAGCCTGAGGACGCGGCGCC
CACCCCGCCCGGGCCCTCCTCGGAGGGCGGCCCCGCGGAGGCCGAGGTGGACGGCGCGACCCCGACAGAGGGCGACGGCGACGGGGACGG
TGAGGGCGAGGGCGAGGGCGAGGCGGTGCTCATGGAGGAGGACCTGATCCAGCAGAGCCTGGACGACTACGACGCCGGCAGGTACAGCCC
GCGGCTGCTCACGGCGCACGAGCTGCCACTGGACGCGCACGTGCTGGAACCGGATGAGGACCTGCAGCGCCTGCAGCTCTCGCGCCAGCA
GCTCCAGGTCACGGGAGACGCCAGCGAGAGCGCCGAGGACATCTTCTTCCGGCGGGCCAAGGAGGGCATGGGCCAGGACGAGGCGCAGTT
CAGCGTGGAGATGCCACTCACCGGCAAGGCCTACCTGTGGGCCGACAAGTACCGGCCACGCAAGCCGCGCTTCTTCAACCGCGTGCACAC
GGGCTTCGAGTGGAACAAGTACAACCAGACGCACTACGACTTTGACAACCCACCGCCCAAGATCGTGCAGGGATACAAGTTCAACATCTT
CTACCCCGACCTCATCGACAAGCGCTCCACGCCCGAGTACTTCCTGGAGGCCTGCGCCGACAACAAGGATTTCGCCATCCTGCGCTTCCA
CGCGGGGCCGCCCTACGAGGACATCGCTTTCAAGATCGTCAACCGCGAGTGGGAATACTCGCACCGCCACGGCTTCCGCTGCCAGTTTGC
CAACGGCATCTTCCAGCTGTGGTTTCACTTCAAGCGCTACCGCTATCGGCGGCCGGGACCCTGCTGGCGCCCGATCCGCCACTGCAGAAG
AGACCCTCTGTGGACACCCACACTCTGCAGGGACTGGCCCCCAACTCACCCCGTGCTGGCTGGTGGGGTCCATTTCCCCGCAGCGGGGAT
CCCCCCACCTGGCCTGCTCACGGGGCCTTGGAGCATGAGACCAGTGACCCCGAGTTTTGCCCATATCAGGACAGTGGCTCCTTCTCACTC
CCCTTTCTCAGGCCAGGAGGGCCGAGGGCCACACGGGTGCCACAGCCCAGGTCGGAGTGGCCCAGCCGGCAGGCTTGTTCTTCAGCATCC
GACGGGAACATCTCCAACAGAAGCAAAACGGAAAGTGCCTCCCGGACCCCCAGAGGGCCACCCAACCTCACCAGTCACCAGCCCCAGACC
ACCCACAGCCCCTCCCAGACACCCCGCCTCATCTGGAAATAGTTCCGTTTGTTTCTCTAAAAAGACTTGTAGGTGGGAAAAAAAATCTTT

>49498_49498_1_LPCAT2-CACTIN_LPCAT2_chr16_55571544_ENST00000262134_CACTIN_chr19_3620270_ENST00000221899_length(amino acids)=991AA_BP=301
MQRPRRSLRPGSTPGSTMSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVLLGIILLPIRVLLV
ALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSM
VSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNK
LDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEVKQLRLEREREKAMREQELEMLQREKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRA
KPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNADFWRDMTTITEDEISKLRKLEASGKGPGERREGVN
ASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLYKLKQEQGVESEPLFPILKQ
EPQSPSRSLEPEDAAPTPPGPSSEGGPAEAEVDGATPTEGDGDGDGEGEGEGEAVLMEEDLIQQSLDDYDAGRYSPRLLTAHELPLDAHV
LEPDEDLQRLQLSRQQLQVTGDASESAEDIFFRRAKEGMGQDEAQFSVEMPLTGKAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDF
DNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYR
YRRPGPCWRPIRHCRRDPLWTPTLCRDWPPTHPVLAGGVHFPAAGIPPPGLLTGPWSMRPVTPSFAHIRTVAPSHSPFSGQEGRGPHGCH
SPGRSGPAGRLVLQHPTGTSPTEAKRKVPPGPPEGHPTSPVTSPRPPTAPPRHPASSGNSSVCFSKKTCRWEKKSFVLMELAYWQDRMFF

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>49498_49498_2_LPCAT2-CACTIN_LPCAT2_chr16_55571544_ENST00000262134_CACTIN_chr19_3620270_ENST00000248420_length(transcript)=2914nt_BP=1036nt
AGAGCCTGGGGCGTGTCACAGCCGAAGGGGCAGGGCGGCAGCAGCAGGCGTCTAAGTAACTTCAGCGCCTGCGCAGAGGCTCCCCAGCGT
CGCCCTAGGCTGGGACTCTAGTAGGTCTTCGGCTCAGTTTTGGCTGCAGCGCCCGCGTAGATCGCTTCGGCCGGGTTCTACGCCCGGCTC
AACTATGAGCCGGTGCGCCCAGGCGGCGGAAGTGGCGGCCACAGTGCCAGGTGCCGGCGTCGGGAACGTGGGGCTGCGGCCGCCCATGGT
GCCCCGTCAGGCGTCCTTCTTCCCGCCGCCGGTGCCGAACCCCTTCGTGCAGCAGACGCAGATCGGCTCCGCGAGGCGGGTCCAGATTGT
CCTTCTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCATGGCCATTTGCTGCAATTTCAACAGT
ATGCTGTCCTGAAAAGCTGACCCACCCAATAACTGGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGTCGTGCTATGTT
CTTTTCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTTTTTGTTGCTGCCCCTCATTCAACATT
CTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTACCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATTGGCAGACTGTT
ACGGGCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAATGAAATAATAAAGCGAACAACATCAGG
AGGAGAATGGCCCCAGATACTAGTTTTCCCAGAAGGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGAGCCTTCATTCC
AGGAGTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACATGGCAAGGATATACATTCATTCAGCT
TTGTATGCTTACTTTCTGCCAGCTCTTCACAAAGGTAGAAGTTGAGGTGAAGCAGCTGCGGCTGGAGCGGGAGCGGGAGAAGGCCATGCG
CGAGCAGGAGCTGGAGATGCTGCAGCGCGAGAAGGAGGCAGAGCACTTCAAGACATGGGAGGAGCAGGAGGACAACTTCCACCTCCAGCA
GGCCAAGCTGCGTTCCAAGATCCGCATCCGGGACGGGCGGGCCAAGCCCATCGACCTGCTGGCCAAGTACATCAGCGCTGAGGATGACGA
TCTGGCCGTGGAGATGCATGAGCCCTACACGTTCCTCAACGGCCTCACCGTGGCCGACATGGAGGACCTGCTGGAGGATATCCAGGTCTA
CATGGAGCTGGAGCAGGGCAAGAACGCCGACTTCTGGCGGGACATGACCACCATCACCGAGGACGAGATCTCCAAGCTCCGCAAGCTGGA
GGCCTCGGGCAAGGGGCCAGGTGAGCGCCGCGAGGGGGTCAACGCCTCCGTCAGCTCTGATGTGCAGTCGGTGTTCAAGGGGAAGACATA
CAACCAGCTGCAGGTCATCTTCCAGGGCATCGAGGGCAAAATCCGCGCTGGTGGCCCCAACCTGGACATGGGCTACTGGGAGAGCCTCCT
GCAGCAGCTTCGTGCCCACATGGCACGGGCCCGGCTGCGTGAGCGCCACCAGGACGTGCTGCGGCAGAAGCTGTACAAACTGAAGCAGGA
GCAGGGCGTGGAGAGCGAGCCGCTGTTCCCCATCCTCAAGCAGGAGCCCCAGTCCCCCAGCCGCAGCCTGGAGCCTGAGGACGCGGCGCC
CACCCCGCCCGGGCCCTCCTCGGAGGGCGGCCCCGCGGAGGCCGAGGTGGACGGCGCGACCCCGACAGAGGGCGACGGCGACGGGGACGG
TGAGGGCGAGGGCGAGGGCGAGGCGGTGCTCATGGAGGAGGACCTGATCCAGCAGAGCCTGGACGACTACGACGCCGGCAGGTACAGCCC
GCGGCTGCTCACGGCGCACGAGCTGCCACTGGACGCGCACGTGCTGGAACCGGATGAGGACCTGCAGCGCCTGCAGCTCTCGCGCCAGCA
GCTCCAGGTCACGGGAGACGCCAGCGAGAGCGCCGAGGACATCTTCTTCCGGCGGGCCAAGGAGGGCATGGGCCAGGACGAGGCGCAGTT
CAGCGTGGAGATGCCACTCACCGGCAAGGCCTACCTGTGGGCCGACAAGTACCGGCCACGCAAGCCGCGCTTCTTCAACCGCGTGCACAC
GGGCTTCGAGTGGAACAAGTACAACCAGACGCACTACGACTTTGACAACCCACCGCCCAAGATCGTGCAGGGATACAAGTTCAACATCTT
CTACCCCGACCTCATCGACAAGCGCTCCACGCCCGAGTACTTCCTGGAGGCCTGCGCCGACAACAAGGATTTCGCCATCCTGCGCTTCCA
CGCGGGGCCGCCCTACGAGGACATCGCTTTCAAGATCGTCAACCGCGAGTGGGAATACTCGCACCGCCACGGCTTCCGCTGCCAGTTTGC
CAACGGCATCTTCCAGCTGTGGTTTCACTTCAAGCGCTACCGCTATCGGCGGTGACGGCCCTGGGGAACGGCAGGCCAGGAGGGCCGAGG
GCCACACGGGTGCCACAGCCCAGGTCGGAGTGGCCCAGCCGGCAGGCTTGTTCTTCAGCATCCGACGGGAACATCTCCAACAGAAGCAAA
ACGGAAAGTGCCTCCCGGACCCCCAGAGGGCCACCCAACCTCACCAGTCACCAGCCCCAGACCACCCACAGCCCCTCCCAGACACCCCGC
CTCATCTGGAAATAGTTCCGTTTGTTTCTCTAAAAAGACTTGTAGGTGGGAAAAAAAATCTTTTGTTCTCATGGAATTGGCCTATTGGCA

>49498_49498_2_LPCAT2-CACTIN_LPCAT2_chr16_55571544_ENST00000262134_CACTIN_chr19_3620270_ENST00000248420_length(amino acids)=813AA_BP=301
MQRPRRSLRPGSTPGSTMSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVLLGIILLPIRVLLV
ALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSM
VSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNK
LDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEVKQLRLEREREKAMREQELEMLQREKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRA
KPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNADFWRDMTTITEDEISKLRKLEASGKGPGERREGVN
ASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLYKLKQEQGVESEPLFPILKQ
EPQSPSRSLEPEDAAPTPPGPSSEGGPAEAEVDGATPTEGDGDGDGEGEGEGEAVLMEEDLIQQSLDDYDAGRYSPRLLTAHELPLDAHV
LEPDEDLQRLQLSRQQLQVTGDASESAEDIFFRRAKEGMGQDEAQFSVEMPLTGKAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDF
DNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYR

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>49498_49498_3_LPCAT2-CACTIN_LPCAT2_chr16_55571544_ENST00000262134_CACTIN_chr19_3620270_ENST00000429344_length(transcript)=3857nt_BP=1036nt
AGAGCCTGGGGCGTGTCACAGCCGAAGGGGCAGGGCGGCAGCAGCAGGCGTCTAAGTAACTTCAGCGCCTGCGCAGAGGCTCCCCAGCGT
CGCCCTAGGCTGGGACTCTAGTAGGTCTTCGGCTCAGTTTTGGCTGCAGCGCCCGCGTAGATCGCTTCGGCCGGGTTCTACGCCCGGCTC
AACTATGAGCCGGTGCGCCCAGGCGGCGGAAGTGGCGGCCACAGTGCCAGGTGCCGGCGTCGGGAACGTGGGGCTGCGGCCGCCCATGGT
GCCCCGTCAGGCGTCCTTCTTCCCGCCGCCGGTGCCGAACCCCTTCGTGCAGCAGACGCAGATCGGCTCCGCGAGGCGGGTCCAGATTGT
CCTTCTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCATGGCCATTTGCTGCAATTTCAACAGT
ATGCTGTCCTGAAAAGCTGACCCACCCAATAACTGGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGTCGTGCTATGTT
CTTTTCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTTTTTGTTGCTGCCCCTCATTCAACATT
CTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTACCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATTGGCAGACTGTT
ACGGGCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAATGAAATAATAAAGCGAACAACATCAGG
AGGAGAATGGCCCCAGATACTAGTTTTCCCAGAAGGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGAGCCTTCATTCC
AGGAGTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACATGGCAAGGATATACATTCATTCAGCT
TTGTATGCTTACTTTCTGCCAGCTCTTCACAAAGGTAGAAGTTGAGGTGAAGCAGCTGCGGCTGGAGCGGGAGCGGGAGAAGGCCATGCG
CGAGCAGGAGCTGGAGATGCTGCAGCGCGAGAAGGAGGCAGAGCACTTCAAGACATGGGAGGAGCAGGAGGACAACTTCCACCTCCAGCA
GGCCAAGCTGCGTTCCAAGATCCGCATCCGGGACGGGCGGGCCAAGCCCATCGACCTGCTGGCCAAGTACATCAGCGCTGAGGATGACGA
TCTGGCCGTGGAGATGCATGAGCCCTACACGTTCCTCAACGGCCTCACCGTGGCCGACATGGAGGACCTGCTGGAGGATATCCAGGTCTA
CATGGAGCTGGAGCAGGGCAAGAACGCCGACTTCTGGCGGGACATGACCACCATCACCGAGGACGAGATCTCCAAGCTCCGCAAGCTGGA
GGCCTCGGGCAAGGGGCCAGGTGAGCGCCGCGAGGGGGTCAACGCCTCCGTCAGCTCTGATGTGCAGTCGGTGTTCAAGGGGAAGACATA
CAACCAGCTGCAGGTCATCTTCCAGGGCATCGAGGGCAAAATCCGCGCTGGTGGCCCCAACCTGGACATGGGCTACTGGGAGAGCCTCCT
GCAGCAGCTTCGTGCCCACATGGCACGGGCCCGGCTGCGTGAGCGCCACCAGGACGTGCTGCGGCAGAAGCTGTACAAACTGAAGCAGGA
GCAGGGCGTGGAGAGCGAGCCGCTGTTCCCCATCCTCAAGCAGGAGCCCCAGTCCCCCAGCCGCAGCCTGGAGCCTGAGGACGCGGCGCC
CACCCCGCCCGGGCCCTCCTCGGAGGGCGGCCCCGCGGAGGCCGAGGTGGACGGCGCGACCCCGACAGAGGGCGACGGCGACGGGGACGG
TGAGGGCGAGGGCGAGGGCGAGGCGGTGCTCATGGAGGAGGACCTGATCCAGCAGAGCCTGGACGACTACGACGCCGGCAGGTACAGCCC
GCGGCTGCTCACGGCGCACGAGCTGCCACTGGACGCGCACGTGCTGGAACCGGATGAGGACCTGCAGCGCCTGCAGCTCTCGCGCCAGCA
GCTCCAGGTCACGGGAGACGCCAGCGAGAGCGCCGAGGACATCTTCTTCCGGCGGGCCAAGGAGGGCATGGGCCAGGACGAGGCGCAGTT
CAGCGTGGAGATGCCACTCACCGGCAAGGCCTACCTGTGGGCCGACAAGTACCGGCCACGCAAGCCGCGCTTCTTCAACCGCGTGCACAC
GGGCTTCGAGTGGAACAAGTACAACCAGACGCACTACGACTTTGACAACCCACCGCCCAAGATCGTGCAGGGATACAAGTTCAACATCTT
CTACCCCGACCTCATCGACAAGCGCTCCACGCCCGAGTACTTCCTGGAGGCCTGCGCCGACAACAAGGATTTCGCCATCCTGCGCTTCCA
CGCGGGGCCGCCCTACGAGGACATCGCTTTCAAGATCGTCAACCGCGAGTGGGAATACTCGCACCGCCACGGCTTCCGCTGCCAGTTTGC
CAACGGCATCTTCCAGCTGTGGTTTCACTTCAAGCGCTACCGCTATCGGCGGTGACGGCCCTGGGGAACGGCAGGCAGGTGTCCTCGGGG
GCACAGTAAAGGGGCTTCGGTGAAGCTGGTGGTCACTCCGGGGCCGCTGTCTGGGCTGCAGGGCCGCGGGTTCACGTCCCACCTCAGGCC
GCATCTTTCTTTCGCCAGGCCTCAGTTTCCTCCTATATAAAAGGGGGGTCACCATTGAGCCTGCCATGGTGAGCTGAGGAGACACTGGGA
CAGGCTGGCCTAGGGTCCTGATGCAACGGAGGGGGCGCTAGGGGCATCTTTCGAGCACGAGGGTGGCCAGCAGCCGCCAGCTGACCTCAC
CGTCCAGGCGGACACTCTCCACCGCCCCTCAGCCAGGCTGGGTGGGGCCCACAGGGCCTGCCCCAAGTGGCGGCCACACAGGGTGTTGTG
GAGATGGGCCAGAGGGGCCTGGGCTTGGCGGTGCCAGGCTCGTGAGAAGCAGGAAACTCAAGGCCAGCCCTGCCACATCACGGGGCACCC
ACTGGGCGTGAGGCAGAGCCCGCGGCTGTGGGGCAGCTCCAGCCCTGCCCACAGGCCACCCTCGCCCGCACAGGCAGCACTGAGGCCGGG
ACCCTGCTGGCGCCCGATCCGCCACTGCAGAAGAGACCCTCTGTGGACACCCACACTCTGCAGGGACTGGCCCCCAACTCACCCCGTGCT
GGCTGGTGGGGTCCATTTCCCCGCAGCGGGTATGGAGGATGCGTCGAGGTCCCTGTCTCTGTCAAGGTCGTGGGAACCAAAAGTCACTGA
GCCGTCCTCCCCCCACCTCTGAGCACAGGGCCTGGAGGGCAGGGGCTCCCCGAAGGCTGGGGGTTGGAGAAGGGTGAGGGGCTTCCCCCA
GGGATCCCCCCACCTGGCCTGCTCACGGGGCCTTGGAGCATGAGACCAGTGACCCCGAGTTTTGCCCATATCAGGACAGTGGCTCCTTCT
CACTCCCCTTTCTCAGGCCAGGAGGGCCGAGGGCCACACGGGTGCCACAGCCCAGGTCGGAGTGGCCCAGCCGGCAGGCTTGTTCTTCAG
CATCCGACGGGAACATCTCCAACAGAAGCAAAACGGAAAGTGCCTCCCGGACCCCCAGAGGGCCACCCAACCTCACCAGTCACCAGCCCC
AGACCACCCACAGCCCCTCCCAGACACCCCGCCTCATCTGGAAATAGTTCCGTTTGTTTCTCTAAAAAGACTTGTAGGTGGGAAAAAAAA

>49498_49498_3_LPCAT2-CACTIN_LPCAT2_chr16_55571544_ENST00000262134_CACTIN_chr19_3620270_ENST00000429344_length(amino acids)=813AA_BP=301
MQRPRRSLRPGSTPGSTMSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVLLGIILLPIRVLLV
ALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSM
VSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNK
LDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEVKQLRLEREREKAMREQELEMLQREKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRA
KPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNADFWRDMTTITEDEISKLRKLEASGKGPGERREGVN
ASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLYKLKQEQGVESEPLFPILKQ
EPQSPSRSLEPEDAAPTPPGPSSEGGPAEAEVDGATPTEGDGDGDGEGEGEGEAVLMEEDLIQQSLDDYDAGRYSPRLLTAHELPLDAHV
LEPDEDLQRLQLSRQQLQVTGDASESAEDIFFRRAKEGMGQDEAQFSVEMPLTGKAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDF
DNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYR

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Fusion Gene PPI Analysis for LPCAT2-CACTIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LPCAT2-CACTIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LPCAT2-CACTIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource