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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LPCAT3-MYO15A (FusionGDB2 ID:49507)

Fusion Gene Summary for LPCAT3-MYO15A

Fusion gene summary

Fusion gene information	Fusion gene name: LPCAT3-MYO15A
	Fusion gene ID: 49507
		Hgene	Tgene
	Gene symbol	LPCAT3	MYO15A
	Gene ID	10162	51168
	Gene name	lysophosphatidylcholine acyltransferase 3	myosin XVA
	Synonyms	C3F\|LPCAT\|LPLAT 5\|LPSAT\|MBOAT5\|OACT5\|nessy	DFNB3\|MYO15
	Cytomap	12p13.31	17p11.2
	Type of gene	protein-coding	protein-coding
	Description	lysophospholipid acyltransferase 51-acylglycerophosphocholine O-acyltransferase1-acylglycerophosphoserine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 5O-acyltransferase domain-containing protein 5lyso-PC acyltransferase 3ly	unconventional myosin-XVmyosin-XVunconventional myosin-15
	Modification date	20200313	20200322
	UniProtAcc	Q6P1A2	Q9UKN7
	Ensembl transtripts involved in fusion gene	ENST00000261407, ENST00000535021,	ENST00000412324, ENST00000418233, ENST00000451725, ENST00000585180, ENST00000205890,
Fusion gene scores	* DoF score	7 X 5 X 6=210	4 X 5 X 3=60
	# samples	6	5
	** MAII score	log2(6/210*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LPCAT3 [Title/Abstract] AND MYO15A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LPCAT3(7090166)-MYO15A(18039025), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LPCAT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO15A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-EW-A6SC-01A	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+

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Fusion Gene ORF analysis for LPCAT3-MYO15A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000261407	ENST00000412324	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5CDS-intron	ENST00000261407	ENST00000418233	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5CDS-intron	ENST00000261407	ENST00000451725	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5CDS-intron	ENST00000261407	ENST00000585180	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5UTR-3CDS	ENST00000535021	ENST00000205890	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5UTR-intron	ENST00000535021	ENST00000412324	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5UTR-intron	ENST00000535021	ENST00000418233	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5UTR-intron	ENST00000535021	ENST00000451725	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
5UTR-intron	ENST00000535021	ENST00000585180	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+
In-frame	ENST00000261407	ENST00000205890	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000261407

LPCAT3

chr12

7090166

ENST00000205890

MYO15A

chr17

18039025

7806

763

823

6873

2016

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261407	ENST00000205890	LPCAT3	chr12	7090166	-	MYO15A	chr17	18039025	+	0.007740744	0.9922592

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Fusion Genomic Features for LPCAT3-MYO15A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LPCAT3	chr12	7090165	-	MYO15A	chr17	18039024	+	3.76E-07	0.99999964
LPCAT3	chr12	7090165	-	MYO15A	chr17	18039024	+	3.76E-07	0.99999964

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LPCAT3-MYO15A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:7090166/chr17:18039025)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LPCAT3 Q6P1A2	MYO15A Q9UKN7
FUNCTION: Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18782225, PubMed:18195019, PubMed:18772128). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18782225, PubMed:18195019, PubMed:18772128). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Downregulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). {ECO:0000250\|UniProtKB:Q91V01, ECO:0000269\|PubMed:18195019, ECO:0000269\|PubMed:18772128, ECO:0000269\|PubMed:18782225}.	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

111_131

225

651.3333333333334

Transmembrane

Helical

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

180_200

225

651.3333333333334

Transmembrane

Helical

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

44_64

225

651.3333333333334

Transmembrane

Helical

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

84_104

225

651.3333333333334

Transmembrane

Helical

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1902_1924

1494

3531.0

Domain

IQ 1

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1925_1954

1494

3531.0

Domain

IQ 2

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1955_1976

1494

3531.0

Domain

IQ 3

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

2065_2217

1494

3531.0

Domain

MyTH4 1

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

2867_2953

1494

3531.0

Domain

SH3

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

3050_3204

1494

3531.0

Domain

MyTH4 2

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

3209_3530

1494

3531.0

Domain

FERM

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1792_1799

1494

3531.0

Region

Actin-binding

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1888_2029

1494

3531.0

Region

Note=Neck or regulatory domain

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

2030_3530

1494

3531.0

Region

Note=Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

484_487

225

651.3333333333334

Motif

Note=Di-lysine motif

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

227_247

225

651.3333333333334

Transmembrane

Helical

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

285_305

225

651.3333333333334

Transmembrane

Helical

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

364_384

225

651.3333333333334

Transmembrane

Helical

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

422_442

225

651.3333333333334

Transmembrane

Helical

Hgene

LPCAT3

chr12:7090166

chr17:18039025

ENST00000261407

453_473

225

651.3333333333334

Transmembrane

Helical

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1323_1350

1494

3531.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1222_1899

1494

3531.0

Domain

Myosin motor

Tgene

MYO15A

chr12:7090166

chr17:18039025

ENST00000205890

1315_1322

1494

3531.0

Nucleotide binding

ATP

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Fusion Gene Sequence for LPCAT3-MYO15A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>49507_49507_1_LPCAT3-MYO15A_LPCAT3_chr12_7090166_ENST00000261407_MYO15A_chr17_18039025_ENST00000205890_length(transcript)=7806nt_BP=763nt
CCGGAATTGGGGGTGAAGCGATAGCGTTTTGCCCGCATTCGGGGCGCGCGGAGCTGGGGGGTCCCTGTGGGGCTCCCGGAGTTAAGATGG
CGTCCTCAGCGGAGGGGGACGAGGGGACTGTGGTGGCGCTGGCGGGGGTTCTGCAGTCGGGTTTCCAGGAGCTGAGCCTTAACAAGTTGG
CGACGTCCCTGGGCGCGTCAGAACAGGCGCTGCGGCTGATCATCTCCATCTTCCTGGGTTACCCCTTTGCTTTGTTTTATCGGCATTACC
TTTTCTACAAGGAGACCTACCTCATCCACCTCTTCCATACCTTTACAGGCCTCTCAATTGCTTATTTTAACTTTGGAAACCAGCTCTACC
ACTCCCTGCTGTGTATTGTGCTTCAGTTCCTCATCCTTCGACTAATGGGCCGCACCATCACTGCCGTCCTCACTACCTTTTGCTTCCAGA
TGGCCTACCTTCTGGCTGGATACTATTACACTGCCACCGGCAACTACGATATCAAGTGGACAATGCCACATTGTGTTCTGACTTTGAAGC
TGATTGGTTTGGCTGTTGACTACTTTGACGGAGGGAAAGATCAGAATTCCTTGTCCTCTGAGCAACAGAAATATGCCATACGTGGTGTTC
CTTCCCTGCTGGAAGTTGCTGGTTTCTCCTACTTCTATGGGGCCTTCTTGGTAGGGCCCCAGTTCTCAATGAATCACTACATGAAGCTGG
TGCAGGGAGAGCTGATTGACATACCAGGAAAGATACCAAACAGACGGATGCACAGGAGGTGGCCTCAGTGGTGAGTGCCCGAGAGATCCA
GGCCGTGGCAGAGCTGCTGCAGATCTCCCCTGAGGGCCTGCAGAAGGCCATCACCTTCAAAGTGACCGAGACAATGCGAGAGAAGATCTT
CACGCCCCTAACTGTGGAGAGCGCTGTGGATGCCAGGGACGCCATCGCCAAGGTCTTGTATGCACTGCTGTTCAGCTGGCTCATCACCAG
GGTCAACGCGCTGGTGTCCCCAAGGCAGGACACACTGTCCATCGCCATCCTGGACATCTATGGTTTCGAGGACCTGAGCTTCAACAGCTT
TGAGCAGCTGTGTATTAACTACGCAAACGAGAACCTTCAGTACCTTTTCAACAAGATCGTCTTCCAGGAGGAGCAGGAGGAGTACATCCG
TGAGCAGATAGACTGGCAGGAGATCACCTTTGCTGACAACCAGCCCTGCATCAACCTCATCTCACTGAAGCCTTATGGCATCCTGCGGAT
CCTTGACGACCAGTGTTGCTTTCCCCAGGCTACAGACCACACCTTCCTACAGAAGTGCCACTACCATCATGGCGCCAACCCGCTCTATTC
CAAACCCAAGATGCCGCTGCCTGAGTTCACCATCAAGCACTATGCAGGCAAGGTCACCTACCAGGTGCACAAGTTCCTGGACAAGAACCA
CGACCAAGTGCGCCAGGATGTGCTGGACCTGTTCGTACGGAGCCGGACACGGGTGGTGGCACACCTCTTCTCCAGCCATGCCCCACAGGC
TGCCCCTCAGCGCCTGGGCAAGAGCAGCTCCGTCACTCGGCTCTACAAGGCGCACACTGTGGCCGCCAAGTTCCAGCAGTCACTCCTGGA
TCTGGTGGAAAAGATGGAGAGGTGCAACCCCTTGTTCATGCGTTGCCTGAAGCCCAACCACAAGAAGGAGCCAGGTCTCTTTGAGCCAGA
TGTGGTAATGGCACAATTACGCTATTCAGGGGTGCTGGAGACCGTGAGGATCCGCAAGGAGGGATTTCCAGTGCGCCTGCCTTTCCAGGG
GTTCATCGACAGGTACTGCTGTCTAGTGGCCCTCAAGCATGACCTGCCGGCTAATGGGGACATGTGTGTGTCAGTGCTGAGTCGCCTGTG
CAAAGTCATGCCAAACATGTACCGTGTTGGGGTCAGCAAGCTGTTCCTTAAGGAACACCTATACCAGCTGCTGGAGAGTATGCGAGAGCA
TGTCCTGAATCTGGCAGCCCTCACTCTGCAGCGCTGCCTCCGTGGCTTCTTCATTAAGCGGCGATTCCGCTCTCTGCGCCACAAGATCAT
CCTGCTGCAAAGCCGGGCCCGTGGCTACCTTGCCAGGCAACGCTATCAGCAGATGAGGAGGAGTCTGGTGAAGTTCCGGTCCCTGGTACA
CGCATACGTGAGCCGCCGACGCTATCTCAAGCTGAGGGCAGAGTGGAGGTGCCAGGTGGAGGGGGCGCTGCTGTGGGAGCAGGAGGAGCT
GAGCAAGCGGGAGGTAGTCGCTGTGGGGCACCTGGAGGTACCGGCTGAGCTGGCTGGGCTCTTGCAAGCAGTGGCAGGCCTCGGGCTGGC
CCAGGTGCCTCAGGTGGCCCCTGTGAGGACTCCTCGACTCCAGGCTGAGCCCCGTGTCACACTGCCCCTGGACATCAACAACTATCCTAT
GGCCAAGTTTGTCCAGTGCCACTTCAAGGAACCTGCCTTTGGGATGCTGACAGTGCCCCTGAGGACACCCCTCACGCAGCTGCCAGCCGA
GCACCATGCAGAAGCCGTGAGCATCTTCAAGCTGATCCTGCGCTTCATGGGCGACCCCCACCTGCATGGTGCCCGGGAGAACATCTTCGG
GAACTACATCGTGCAGAAGGGGCTGGCGGTGCCTGAGCTGCGGGATGAGATCCTGGCACAGCTGGCCAATCAGGTGTGGCACAATCACAA
TGCCCACAATGCTGAGCGGGGCTGGCTGCTGCTGGCCGCCTGCCTCAGTGGCTTTGCACCTTCCCCGTGCTTCAACAAGTACCTTCTCAA
GTTTGTGTCTGATTATGGGCGGAATGGCTTCCAGGCTGTGTGTCAGCACCGCCTCATGCAGGCCATGGGCCGGGCCCAACAGCAGGGCTC
GGGGGCTGCCCGCACCTTACCCCCGACCCAGCTCGAGTGGACAGCGACCTATGAGAAGGCCAGCATGGCGCTGGACGTGGGCTGCTTCAA
TGGTGACCAGTTCTCCTGCCCGGTGCACTCCTGGAGTACGGGGGAAGAGGTGGCTGGAGACATTCTGAGGCACAGGGGGCTGGCAGATGG
CTGGCGCGGCTGGACCGTGGCCATGAAGAATGGTGTCCAGTGGGCAGAGCTGGCTGGCCACGACTACGTGTTAGACCTGGTGTCGGACCT
GGAGCTGCTCAGGGACTTCCCTCGACAGAAGTCCTACTTCATTGTGGGCACAGAGGGGCCTGCAGCCAGCAGGGGAGGCCCCAAAGTGGT
GTTTGGGAACAGCTGGGACTCGGATGAGGACATGTCCACTAGACCCCAGCCCCAGGAGCACATGCCCAAAGTACTTGACTCTGATGGGTA
CAGCAGCCACAATCAGGACGGTACAAATGGGGAGACTGAGGCCCAAAGAGGGACAGCAACCCACCAAGAGTCAGACAGTCTTGGAGAGCC
TGCTGTGCCCCACAAGGGGCTGGACTGCTACCTGGATAGCCTCTTTGACCCTGTGCTGTCCTACGGGGATGCGGACCTGGAGAAGCCAAC
AGCCATTGCCTACCGCATGAAAGGGGGAGGCCAGCCCGGTGGAGGCAGCAGTAGTGGTACTGAAGACACCCCCAGGAGACCCCCAGAGCC
AAAGCCAATCCCAGGCCTGGATGCCTCCACATTGGCTCTGCAGCAAGCCTTCATCCACAAACAGGCCGTGCTGCTGGCCCGGGAGATGAC
CCTGCAGGCCACGGCACTCCAGCAGCAGCCCCTGAGTGCTGCCCTGAGATCCTTGCCCGCAGAGAAACCCCCAGCACCAGAGGCACAGCC
GACGTCTGTAGGCACCGGTCCCCCTGCCAAACCCGTGCTCCTGCGTGCCACTCCAAAGCCCTTGGCCCCAGCCCCTCTGGCCAAGGCTCC
AAGGCTCCCCATCAAGCCTGTGGCTGCCCCTGTTCTAGCTCAGGATCAGGCTTCTCCAGAAACCACTTCACCCTCCCCAGAGCTGGTCCG
GTACTCTACGCTCAACTCTGAGCACTTCCCACAGCCCACACAGCAGATCAAGAATATTGTCAGGCAGTACCAGCAGCCGTTCCGGGGAGG
CCGGCCTGAGGCCCTCAGGAAGGATGGCGGGAAAGTGTTCATGAAGCGGCCAGACCCTCATGAGGAGGCCCTGATGATCCTGAAAGGGCA
GATGACCCACCTGGCAGCTGCACCTGGCACCCAGGTGTCCAGAGAGGCCGTGGCCCTGGTGAAGCCGGTGACCAGTGCACCAAGGCCATC
CATGGCACCCACTTCAGCTCTGCCCTCGCGATCGCTGGAGCCCCCTGAGGAACTCACGCAGACGCGGCTGCACCGCCTCATCAATCCCAA
CTTCTACGGCTATCAGGACGCCCCCTGGAAGATCTTCCTGCGCAAAGAGGTGTTTTACCCCAAGGACAGCTACAGCCATCCTGTGCAGCT
TGACCTCCTGTTCCGGCAGATCCTGCACGACACGCTCTCCGAGGCCTGCCTTCGCATCTCTGAGGATGAGAGGCTCAGGATGAAGGCCTT
GTTTGCCCAGAACCAGCTGGACACACAGAAGCCTCTGGTAACGGAAAGCGTGAAGCGGGCCGTGGTCAGCACTGCACGAGACACCTGGGA
GGTCTACTTCTCCCGCATCTTCCCCGCCACGGGCAGCGTGGGCACTGGTGTGCAGCTCCTAGCTGTGTCCCACGTGGGCATCAAACTCCT
GAGGATGGTCAAGGGTGGCCAGGAGGCCGGCGGGCAGCTGCGGGTCCTGCGTGCATACAGCTTTGCAGATATCCTGTTTGTGACCATGCC
CTCCCAGAACATGCTGGAGTTCAACCTGGCCAGTGAGAAGGTCATCCTCTTCTCAGCCCGAGCGCACCAGGTCAAGACCCTGGTAGATGA
CTTCATCTTGGAGCTGAAGAAGGACTCTGACTACGTGGTCGCTGTGAGGAACTTCCTGCCTGAGGACCCTGCGCTGCTGGCTTTCCACAA
GGGTGACATCATACACCTGCAGCCCCTAGAGCCACCTCGAGTGGGCTACAGTGCTGGCTGCGTGGTTCGCAGGAAGGTGGTGTACCTGGA
GGAGCTGCGACGTAGAGGCCCCGACTTTGGCTGGAGGTTCGGGACCATCCACGGGCGCGTGGGCCGCTTCCCTTCGGAGCTGGTGCAGCC
CGCTGCTGCCCCCGACTTCCTGCAGCTGCCAACGGAGCCAGGCCGCGGCCGAGCAGCCGCCGTGGCCGCTGCTGTGGCCTCTGCAGCCGC
TGCACAGGAGGTGGGCCGCAGGAGAGAGGGTCCCCCAGTCAGGGCCCGCTCTGCTGACCATGGGGAGGACGCCCTGGCGCTCCCACCCTA
CACAATGCTCGAGTTTGCCCAGAAGTATTTCCGAGACCCTCAGAGGAGACCCCAGGATGGCCTCAGGCTGAAATCCAAGGAGCCTCGGGA
GTCCAGAACCTTGGAGGACATGCTTTGCTTCACCAAGACTCCCCTCCAGGAATCCCTCATCGAACTCAGCGACAGCAGCCTCAGCAAGAT
GGCCACCGACATGTTCCTAGCTGTAATGAGGTTCATGGGGGATGCCCCACTGAAGGGCCAGAGTGACCTGGACGTGCTTTGTAACCTCCT
GAAGCTGTGCGGGGACCATGAGGTCATGCGGGATGAATGTTACTGCCAAGTTGTGAAGCAGATCACAGACAATACCAGCTCCAAGCAGGA
CAGCTGCCAGCGAGGCTGGAGGCTGCTGTATATCGTGACCGCCTACCACAGCTGCTCTGAGGTCCTCCACCCACACCTCACTCGCTTCCT
CCAAGACGTGAGCCGGACCCCAGGCCTGCCCTTTCAGGGGATCGCCAAGGCCTGCGAGCAGAACCTGCAGAAAACCTTGCGCTTCGGAGG
TCGTCTGGAGCTCCCCAGCAGCATAGAGCTTCGGGCCATGTTGGCAGGCCGCAGTTCCAAGAGGCAACTCTTTCTTCTTCCTGGAGGCCT
TGAACGCCATCTCAAAATCAAAACATGCACTGTGGCCCTGGACGTGGTGGAAGAGATATGTGCTGAGATGGCTCTGACACGCCCTGAGGC
CTTCAATGAATATGTTATCTTCGTTGTCACCAACCGTGGCCAGCATGTGTGCCCACTCAGTCGCCGTGCTTACATCCTGGATGTGGCCTC
AGAGATGGAGCAGGTGGACGGCGGCTACATGCTCTGGTTCCGGCGTGTGCTCTGGGATCAGCCACTCAAGTTCGAGAATGAGCTATATGT
GACCATGCACTACAACCAGGTCCTGCCTGACTACCTGAAGGGACTCTTCAGCAGTGTGCCGGCCAGCCGGCCCAGCGAGCAGCTGCTGCA
GCAGGTGTCCAAGCTGGCTTCACTGCAGCATCGCGCCAAGGACCACTTCTACCTGCCGAGCGTGCGGGAAGTCCAGGAGTACATCCCAGC
CCAGCTCTACCGTACAACGGCAGGCTCGACCTGGCTCAACCTGGTCAGCCAGCACCGGCAGCAGACACAGGCGCTCAGCCCCCACCAGGC
CCGTGCCCAGTTTCTGGGCCTCCTCAGCGCCTTACCTATGTTCGGCTCCTCCTTCTTCTTCATCCAGAGCTGCAGCAACATTGCTGTGCC
AGCCCCTTGCATCCTTGCCATCAACCACAATGGCCTCAACTTTCTCAGCACAGAGACTCATGAATTGATGGTGAAGTTCCCCCTGAAGGA
GATCCAGTCGACGCGGACCCAGCGGCCCACGGCCAACTCCAGCTACCCCTATGTGGAGATTGCGCTGGGGGACGTGGCGGCCCAGCGCAC
CTTGCAGCTGCAGCTGGAGCAGGGACTGGAACTGTGTCGTGTGGTGGCCGTGCACGTGGAGAACCTGCTCAGTGCCCATGAGAAGCGGCT
CACATTGCCCCCCAGCGAGATCACCCTGCTCTGACCCAGCCCCCAGCCCTCCAGTACCTTCTGCCAGAAGACTCACTGTGTGGCCTCAGA
GAAATCACTGAACCTCTCAGGATCAATGACCCCTGTAAGGGGCCAGAGCCTTGGAGGACACTAAGAGGAGGCAGGAGGAGCAACTCAAAT
CCCCAAGAACACAAGAAGACCCATCCTGAACTGGGATGGAATGGCAGCATGCAAACTTGGATCAGATAGCAGGAGGAACTTTCAAAAGTC
TGGCCCACTGTGCAGTGGAGCAGAAGGCAGGACCATGAGGCCTCCTGCCATGTACCCATTGCAGACCCTGCCCCTAACTCCTGCCTATGA
CACAGAAGCCCCACACCAGTTGCCCAGATGAACTGGCCTCTGCCTTTGGTTTACTCAGGGTCTGATGTTGGAATCTGCTCCAACTCCACA
CCCTAGCCCTTACATGTCCTCCTAAGGGGCCCCTCCTTGTGCTGCCAGTCAGCCTGGATTTCTGGTCTTTGGTTATTTCTGTGCAAACAA
AAGGTGTGCCTGGCAGCCATTTCTCCATGGAGTTGCTAAGTGGCCGGAAAACAAGCCTGAGGGAGGAGGCAGGAGTTGGAGTTACCTTAG
GCCCCTGATTCACTGCCTATGAACAGACCATCCCCCACTCCTTGGGTATCCCCAACCCCAGACCCCCATCACTTGATGGGCCACACAAGT
TTGAGAGTGGTACAAGGGAGAAGTTTGGGAAAAGCCTTCTTGGAAAATGGGACATTAGCATTGAGTTTTGAAAGATGAGTAGGAGTTTGC
TAAGAATAGATGGAAGACAGCAGGATAAACATTCCAGAGAAAATCATGTTTATTCCCTGCTGTATCTTCCAGAACCTAGGAGGATGCCTA

>49507_49507_1_LPCAT3-MYO15A_LPCAT3_chr12_7090166_ENST00000261407_MYO15A_chr17_18039025_ENST00000205890_length(amino acids)=2016AA_BP=
MLQISPEGLQKAITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSPRQDTLSIAILDIYGFEDLSFNSFEQLC
INYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKM
PLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLVEK
MERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCCLVALKHDLPANGDMCVSVLSRLCKVMP
NMYRVGVSKLFLKEHLYQLLESMREHVLNLAALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSLVKFRSLVHAYVS
RRRYLKLRAEWRCQVEGALLWEQEELSKREVVAVGHLEVPAELAGLLQAVAGLGLAQVPQVAPVRTPRLQAEPRVTLPLDINNYPMAKFV
QCHFKEPAFGMLTVPLRTPLTQLPAEHHAEAVSIFKLILRFMGDPHLHGARENIFGNYIVQKGLAVPELRDEILAQLANQVWHNHNAHNA
ERGWLLLAACLSGFAPSPCFNKYLLKFVSDYGRNGFQAVCQHRLMQAMGRAQQQGSGAARTLPPTQLEWTATYEKASMALDVGCFNGDQF
SCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFIVGTEGPAASRGGPKVVFGNS
WDSDEDMSTRPQPQEHMPKVLDSDGYSSHNQDGTNGETEAQRGTATHQESDSLGEPAVPHKGLDCYLDSLFDPVLSYGDADLEKPTAIAY
RMKGGGQPGGGSSSGTEDTPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQATALQQQPLSAALRSLPAEKPPAPEAQPTSVG
TGPPAKPVLLRATPKPLAPAPLAKAPRLPIKPVAAPVLAQDQASPETTSPSPELVRYSTLNSEHFPQPTQQIKNIVRQYQQPFRGGRPEA
LRKDGGKVFMKRPDPHEEALMILKGQMTHLAAAPGTQVSREAVALVKPVTSAPRPSMAPTSALPSRSLEPPEELTQTRLHRLINPNFYGY
QDAPWKIFLRKEVFYPKDSYSHPVQLDLLFRQILHDTLSEACLRISEDERLRMKALFAQNQLDTQKPLVTESVKRAVVSTARDTWEVYFS
RIFPATGSVGTGVQLLAVSHVGIKLLRMVKGGQEAGGQLRVLRAYSFADILFVTMPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILE
LKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRVGYSAGCVVRRKVVYLEELRRRGPDFGWRFGTIHGRVGRFPSELVQPAAAP
DFLQLPTEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSADHGEDALALPPYTMLEFAQKYFRDPQRRPQDGLRLKSKEPRESRTL
EDMLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQSDLDVLCNLLKLCGDHEVMRDECYCQVVKQITDNTSSKQDSCQR
GWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLPFQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFLLPGGLERHL
KIKTCTVALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHVCPLSRRAYILDVASEMEQVDGGYMLWFRRVLWDQPLKFENELYVTMHY
NQVLPDYLKGLFSSVPASRPSEQLLQQVSKLASLQHRAKDHFYLPSVREVQEYIPAQLYRTTAGSTWLNLVSQHRQQTQALSPHQARAQF
LGLLSALPMFGSSFFFIQSCSNIAVPAPCILAINHNGLNFLSTETHELMVKFPLKEIQSTRTQRPTANSSYPYVEIALGDVAAQRTLQLQ

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Fusion Gene PPI Analysis for LPCAT3-MYO15A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LPCAT3-MYO15A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LPCAT3-MYO15A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source