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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LPHN1-EMR3 (FusionGDB2 ID:49519)

Fusion Gene Summary for LPHN1-EMR3

check button Fusion gene summary
Fusion gene informationFusion gene name: LPHN1-EMR3
Fusion gene ID: 49519
HgeneTgene
Gene symbol

LPHN1

EMR3

Gene ID

22859

84658

Gene nameadhesion G protein-coupled receptor L1adhesion G protein-coupled receptor E3
SynonymsCIRL1|CL1|LEC2|LPHN1EMR3
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionadhesion G protein-coupled receptor L1CIRL-1calcium-independent alpha-latrotoxin receptor 1latrophilin-1lectomedin-2adhesion G protein-coupled receptor E3EGF-like module receptor 3EGF-like module-containing mucin-like hormone receptor-like 3egf-like module containing, mucin-like, hormone receptor-like 3egf-like module-containing mucin-like receptor 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000340736, ENST00000361434, 
ENST00000591528, 		ENST00000253673, 
ENST00000344373, ENST00000595472, 
ENST00000599900, ENST00000443157, 
Fusion gene scores* DoF score4 X 5 X 4=803 X 3 X 2=18
# samples 74
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LPHN1 [Title/Abstract] AND EMR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPHN1(14294345)-EMR3(14779664), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LPHN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EMR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0787-01ALPHN1chr19

14294345

-EMR3chr19

14779664

-


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Fusion Gene ORF analysis for LPHN1-EMR3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000340736ENST00000253673LPHN1chr19

14294345

-EMR3chr19

14779664

-
5CDS-5UTRENST00000340736ENST00000344373LPHN1chr19

14294345

-EMR3chr19

14779664

-
5CDS-5UTRENST00000340736ENST00000595472LPHN1chr19

14294345

-EMR3chr19

14779664

-
5CDS-5UTRENST00000340736ENST00000599900LPHN1chr19

14294345

-EMR3chr19

14779664

-
5CDS-5UTRENST00000361434ENST00000253673LPHN1chr19

14294345

-EMR3chr19

14779664

-
5CDS-5UTRENST00000361434ENST00000344373LPHN1chr19

14294345

-EMR3chr19

14779664

-
5CDS-5UTRENST00000361434ENST00000595472LPHN1chr19

14294345

-EMR3chr19

14779664

-
5CDS-5UTRENST00000361434ENST00000599900LPHN1chr19

14294345

-EMR3chr19

14779664

-
In-frameENST00000340736ENST00000443157LPHN1chr19

14294345

-EMR3chr19

14779664

-
In-frameENST00000361434ENST00000443157LPHN1chr19

14294345

-EMR3chr19

14779664

-
intron-3CDSENST00000591528ENST00000443157LPHN1chr19

14294345

-EMR3chr19

14779664

-
intron-5UTRENST00000591528ENST00000253673LPHN1chr19

14294345

-EMR3chr19

14779664

-
intron-5UTRENST00000591528ENST00000344373LPHN1chr19

14294345

-EMR3chr19

14779664

-
intron-5UTRENST00000591528ENST00000595472LPHN1chr19

14294345

-EMR3chr19

14779664

-
intron-5UTRENST00000591528ENST00000599900LPHN1chr19

14294345

-EMR3chr19

14779664

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340736LPHN1chr1914294345-ENST00000443157EMR3chr1914779664-2240368251923632
ENST00000361434LPHN1chr1914294345-ENST00000443157EMR3chr1914779664-222235071905632

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340736ENST00000443157LPHN1chr1914294345-EMR3chr1914779664-0.0226090760.9773909
ENST00000361434ENST00000443157LPHN1chr1914294345-EMR3chr1914779664-0.0236714040.97632855

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Fusion Genomic Features for LPHN1-EMR3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LPHN1-EMR3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14294345/chr19:14779664)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEMR3chr19:14294345chr19:14779664ENST0000025367301624_668653.0DomainEGF-like 1
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016301_3508653.0DomainGPS
TgeneEMR3chr19:14294345chr19:14779664ENST0000034437301524_668601.0DomainEGF-like 1
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015301_3508601.0DomainGPS
TgeneEMR3chr19:14294345chr19:14779664ENST0000025367301622_3578653.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016379_3898653.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016411_4168653.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016438_4648653.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016486_5088653.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016530_5578653.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016579_5808653.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016602_6528653.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST0000034437301522_3578601.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015379_3898601.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015411_4168601.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015438_4648601.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015486_5088601.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015530_5578601.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015579_5808601.0Topological domainExtracellular
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015602_6528601.0Topological domainCytoplasmic
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016358_3788653.0TransmembraneHelical%3B Name%3D1
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016390_4108653.0TransmembraneHelical%3B Name%3D2
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016417_4378653.0TransmembraneHelical%3B Name%3D3
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016465_4858653.0TransmembraneHelical%3B Name%3D4
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016509_5298653.0TransmembraneHelical%3B Name%3D5
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016558_5788653.0TransmembraneHelical%3B Name%3D6
TgeneEMR3chr19:14294345chr19:14779664ENST00000253673016581_6018653.0TransmembraneHelical%3B Name%3D7
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015358_3788601.0TransmembraneHelical%3B Name%3D1
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015390_4108601.0TransmembraneHelical%3B Name%3D2
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015417_4378601.0TransmembraneHelical%3B Name%3D3
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015465_4858601.0TransmembraneHelical%3B Name%3D4
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015509_5298601.0TransmembraneHelical%3B Name%3D5
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015558_5788601.0TransmembraneHelical%3B Name%3D6
TgeneEMR3chr19:14294345chr19:14779664ENST00000344373015581_6018601.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241303_1314231475.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241315_1318231475.0Compositional biasNote=Poly-Gly
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241410_1420231475.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224413_416231475.0Compositional biasNote=Poly-Thr
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231303_1314231470.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231315_1318231470.0Compositional biasNote=Poly-Gly
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231410_1420231470.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223413_416231470.0Compositional biasNote=Poly-Thr
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224139_398231475.0DomainOlfactomedin-like
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-22440_129231475.0DomainSUEL-type lectin
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224799_850231475.0DomainGPS
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223139_398231470.0DomainOlfactomedin-like
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-22340_129231470.0DomainSUEL-type lectin
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223799_850231470.0DomainGPS
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224117_120231475.0RegionCarbohydrate binding
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223117_120231470.0RegionCarbohydrate binding
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241024_1050231475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241072_1075231475.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241097_1474231475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-22425_858231475.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224880_893231475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224915_920231475.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224942_964231475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224986_1002231475.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231024_1050231470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231072_1075231470.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231097_1474231470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-22325_858231470.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223880_893231470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223915_920231470.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223942_964231470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223986_1002231470.0Topological domainExtracellular
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241003_1023231475.0TransmembraneHelical%3B Name%3D5
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241051_1071231475.0TransmembraneHelical%3B Name%3D6
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-2241076_1096231475.0TransmembraneHelical%3B Name%3D7
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224859_879231475.0TransmembraneHelical%3B Name%3D1
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224894_914231475.0TransmembraneHelical%3B Name%3D2
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224921_941231475.0TransmembraneHelical%3B Name%3D3
HgeneLPHN1chr19:14294345chr19:14779664ENST00000340736-224965_985231475.0TransmembraneHelical%3B Name%3D4
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231003_1023231470.0TransmembraneHelical%3B Name%3D5
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231051_1071231470.0TransmembraneHelical%3B Name%3D6
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-2231076_1096231470.0TransmembraneHelical%3B Name%3D7
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223859_879231470.0TransmembraneHelical%3B Name%3D1
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223894_914231470.0TransmembraneHelical%3B Name%3D2
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223921_941231470.0TransmembraneHelical%3B Name%3D3
HgeneLPHN1chr19:14294345chr19:14779664ENST00000361434-223965_985231470.0TransmembraneHelical%3B Name%3D4


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Fusion Gene Sequence for LPHN1-EMR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49519_49519_1_LPHN1-EMR3_LPHN1_chr19_14294345_ENST00000340736_EMR3_chr19_14779664_ENST00000443157_length(transcript)=2240nt_BP=368nt
TCTTTTTTTTTTTTTTTCCTAATTTTTGGTCGGCGGCGGTGCTGGGCCAGGGGAAGGAAGGGACACGGAGGCCGCCCTCGTCCCGCCACC
TCCTACCCGCTTCCCCCCAGCCCCGGCTCCGGGAGATGTGCCGGGCGGGGGGCCCGGGTTCGCCGAGCCGCAGGAGAGACACGCTGGGCC
GACCCCAGAGAGGCGCTGGACAGGCTGGTGGTCCAGGCCGTGGTGCCTGCCAGGTGATGTGGGGCAAAGCCCCCCGCACAGGCCACTGAG
AGCTCCGGACACGCACCCGGCTGCCACCATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGC
CACCCAAGGCCTCTGCTTTCTGCTGAGCCTCTTTGGAGCTGTGACTCAGAAAACCAAAACTTCCTGTGCTAAGTGCCCCCCAAATGCTTC
CTGTGTCAATAACACTCACTGCACCTGCAACCATGGATATACTTCTGGATCTGGGCAGAAACTATTCACATTCCCCTTGGAGACATGTAA
CGCTATTGAAACTCAAGCGATTACAGACAATTGCTCTGAAGAAAGAAAGACATTCAACTTGAACGTCCAAATGAACTCAATGGACATCCG
TTGCAGTGACATCATCCAGGGAGACACACAAGGTCCCAGTGCCATTGCCTTTATCTCATATTCTTCTCTTGGAAACATCATAAATGCAAC
TTTTTTTGAAGAGATGGATAAGAAAGATCAAGTGTATCTGAACTCTCAGGTTGTGAGTGCTGCTATTGGACCCAAAAGGAACGTGTCTCT
CTCCAAGTCTGTGACGCTGACTTTCCAGCACGTGAAGATGACCCCCAGTACCAAAAAGGTCTTCTGTGTCTACTGGAAGAGCACAGGGCA
GGGCAGCCAGTGGTCCAGGGATGGCTGCTTCCTGATACACGTGAACAAGAGTCACACCATGTGTAATTGCAGTCACCTGTCCAGCTTCGC
TGTCCTGATGGCCCTGACCAGCCAGGAGGAGGATCCCGTGCTGACTGTCATCACCTACGTGGGGCTGAGCGTCTCTCTGCTGTGCCTCCT
CCTGGCGGCCCTCACTTTTCTCCTGTGTAAAGCCATCCGGAACACCAGCACCTCACTGCATCTGCAGCTCTCGCTCTGCCTCTTCCTGGC
CCACCTCCTCTTCCTCGTGGGGATTGATCGAACTGAACCCAAGGTGCTGTGCTCCATCATCGCCGGTGCTTTGCACTATCTCTACCTGGC
CGCCTTCACCTGGATGCTGCTGGAGGGTGTGCACCTCTTCCTCACTGCACGGAACCTGACAGTGGTCAACTACTCAAGCATCAATAGACT
CATGAAGTGGATCATGTTCCCAGTCGGCTATGGCGTTCCCGCTGTGACTGTGGCCATTTCTGCAGCCTCCTGGCCTCACCTTTATGGAAC
TGCTGATCGATGCTGGCTCCACCTGGACCAGGGATTCATGTGGAGTTTCCTTGGCCCAGTCTGTGCCATTTTCTCTGCGAATTTAGTATT
GTTTATCTTGGTCTTTTGGATTTTGAAAAGAAAACTTTCCTCCCTCAATAGTGAAGTGTCAACCATCCAGAACACAAGGATGCTGGCTTT
CAAAGCAACAGCTCAGCTCTTCATCCTGGGCTGCACATGGTGTCTGGGCTTGCTACAGGTGGGTCCAGCTGCCCAGGTCATGGCCTACCT
CTTCACCATCATCAACAGCCTCCAAGGCTTCTTCATCTTCTTGGTCTACTGCCTCCTCAGCCAGCAGGTCCAGAAACAATATCAAAAGTG
GTTTAGAGAGATCGTAAAATCAAAATCTGAGTCTGAGACATACACACTTTCCAGCAAGATGGGTCCTGACTCAAAACCCAGTGAGGGGGA
TGTTTTTCCAGGACAAGTGAAGAGAAAATATTAAAACTAGAATATTCAACTCCATATGGAAAATCATATCCATGGATCTCTTTGGCATTA
TGAAGAATGAAGCTAAGGAAAAGGGAATTCATTAAACATATCATCCTTGGAGAGGAAGTAATCAACCTTTACTTCCCAAGCTGTTTGTTC
TCCACAATAGGCTCTCAACAAATGTGTGGTAAATTGCATTTCTCTTCACTATGGTGTATTCAGTCAATGCTTGTCCCTGGAAACCCAAAG

>49519_49519_1_LPHN1-EMR3_LPHN1_chr19_14294345_ENST00000340736_EMR3_chr19_14779664_ENST00000443157_length(amino acids)=632AA_BP=114
MVGGGAGPGEGRDTEAALVPPPPTRFPPAPAPGDVPGGGPGFAEPQERHAGPTPERRWTGWWSRPWCLPGDVGQSPPHRPLRAPDTHPAA
TMARLAAVLWNLCVTAVLVTSATQGLCFLLSLFGAVTQKTKTSCAKCPPNASCVNNTHCTCNHGYTSGSGQKLFTFPLETCNAIETQAIT
DNCSEERKTFNLNVQMNSMDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTF
QHVKMTPSTKKVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLCLLLAALTFLL
CKAIRNTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKVLCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPV
GYGVPAVTVAISAASWPHLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFI
LGCTWCLGLLQVGPAAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQKQYQKWFREIVKSKSESETYTLSSKMGPDSKPSEGDVFPGQVKR

--------------------------------------------------------------
>49519_49519_2_LPHN1-EMR3_LPHN1_chr19_14294345_ENST00000361434_EMR3_chr19_14779664_ENST00000443157_length(transcript)=2222nt_BP=350nt
CTAATTTTTGGTCGGCGGCGGTGCTGGGCCAGGGGAAGGAAGGGACACGGAGGCCGCCCTCGTCCCGCCACCTCCTACCCGCTTCCCCCC
AGCCCCGGCTCCGGGAGATGTGCCGGGCGGGGGGCCCGGGTTCGCCGAGCCGCAGGAGAGACACGCTGGGCCGACCCCAGAGAGGCGCTG
GACAGGCTGGTGGTCCAGGCCGTGGTGCCTGCCAGGTGATGTGGGGCAAAGCCCCCCGCACAGGCCACTGAGAGCTCCGGACACGCACCC
GGCTGCCACCATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGCCACCCAAGGCCTCTGCTT
TCTGCTGAGCCTCTTTGGAGCTGTGACTCAGAAAACCAAAACTTCCTGTGCTAAGTGCCCCCCAAATGCTTCCTGTGTCAATAACACTCA
CTGCACCTGCAACCATGGATATACTTCTGGATCTGGGCAGAAACTATTCACATTCCCCTTGGAGACATGTAACGCTATTGAAACTCAAGC
GATTACAGACAATTGCTCTGAAGAAAGAAAGACATTCAACTTGAACGTCCAAATGAACTCAATGGACATCCGTTGCAGTGACATCATCCA
GGGAGACACACAAGGTCCCAGTGCCATTGCCTTTATCTCATATTCTTCTCTTGGAAACATCATAAATGCAACTTTTTTTGAAGAGATGGA
TAAGAAAGATCAAGTGTATCTGAACTCTCAGGTTGTGAGTGCTGCTATTGGACCCAAAAGGAACGTGTCTCTCTCCAAGTCTGTGACGCT
GACTTTCCAGCACGTGAAGATGACCCCCAGTACCAAAAAGGTCTTCTGTGTCTACTGGAAGAGCACAGGGCAGGGCAGCCAGTGGTCCAG
GGATGGCTGCTTCCTGATACACGTGAACAAGAGTCACACCATGTGTAATTGCAGTCACCTGTCCAGCTTCGCTGTCCTGATGGCCCTGAC
CAGCCAGGAGGAGGATCCCGTGCTGACTGTCATCACCTACGTGGGGCTGAGCGTCTCTCTGCTGTGCCTCCTCCTGGCGGCCCTCACTTT
TCTCCTGTGTAAAGCCATCCGGAACACCAGCACCTCACTGCATCTGCAGCTCTCGCTCTGCCTCTTCCTGGCCCACCTCCTCTTCCTCGT
GGGGATTGATCGAACTGAACCCAAGGTGCTGTGCTCCATCATCGCCGGTGCTTTGCACTATCTCTACCTGGCCGCCTTCACCTGGATGCT
GCTGGAGGGTGTGCACCTCTTCCTCACTGCACGGAACCTGACAGTGGTCAACTACTCAAGCATCAATAGACTCATGAAGTGGATCATGTT
CCCAGTCGGCTATGGCGTTCCCGCTGTGACTGTGGCCATTTCTGCAGCCTCCTGGCCTCACCTTTATGGAACTGCTGATCGATGCTGGCT
CCACCTGGACCAGGGATTCATGTGGAGTTTCCTTGGCCCAGTCTGTGCCATTTTCTCTGCGAATTTAGTATTGTTTATCTTGGTCTTTTG
GATTTTGAAAAGAAAACTTTCCTCCCTCAATAGTGAAGTGTCAACCATCCAGAACACAAGGATGCTGGCTTTCAAAGCAACAGCTCAGCT
CTTCATCCTGGGCTGCACATGGTGTCTGGGCTTGCTACAGGTGGGTCCAGCTGCCCAGGTCATGGCCTACCTCTTCACCATCATCAACAG
CCTCCAAGGCTTCTTCATCTTCTTGGTCTACTGCCTCCTCAGCCAGCAGGTCCAGAAACAATATCAAAAGTGGTTTAGAGAGATCGTAAA
ATCAAAATCTGAGTCTGAGACATACACACTTTCCAGCAAGATGGGTCCTGACTCAAAACCCAGTGAGGGGGATGTTTTTCCAGGACAAGT
GAAGAGAAAATATTAAAACTAGAATATTCAACTCCATATGGAAAATCATATCCATGGATCTCTTTGGCATTATGAAGAATGAAGCTAAGG
AAAAGGGAATTCATTAAACATATCATCCTTGGAGAGGAAGTAATCAACCTTTACTTCCCAAGCTGTTTGTTCTCCACAATAGGCTCTCAA
CAAATGTGTGGTAAATTGCATTTCTCTTCACTATGGTGTATTCAGTCAATGCTTGTCCCTGGAAACCCAAAGCATGACCACTGCAAATAT

>49519_49519_2_LPHN1-EMR3_LPHN1_chr19_14294345_ENST00000361434_EMR3_chr19_14779664_ENST00000443157_length(amino acids)=632AA_BP=114
MVGGGAGPGEGRDTEAALVPPPPTRFPPAPAPGDVPGGGPGFAEPQERHAGPTPERRWTGWWSRPWCLPGDVGQSPPHRPLRAPDTHPAA
TMARLAAVLWNLCVTAVLVTSATQGLCFLLSLFGAVTQKTKTSCAKCPPNASCVNNTHCTCNHGYTSGSGQKLFTFPLETCNAIETQAIT
DNCSEERKTFNLNVQMNSMDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTF
QHVKMTPSTKKVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLCLLLAALTFLL
CKAIRNTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKVLCSIIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPV
GYGVPAVTVAISAASWPHLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFI
LGCTWCLGLLQVGPAAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQKQYQKWFREIVKSKSESETYTLSSKMGPDSKPSEGDVFPGQVKR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LPHN1-EMR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LPHN1-EMR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LPHN1-EMR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource