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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LPHN1-LGALS4 (FusionGDB2 ID:49520)

Fusion Gene Summary for LPHN1-LGALS4

check button Fusion gene summary
Fusion gene informationFusion gene name: LPHN1-LGALS4
Fusion gene ID: 49520
HgeneTgene
Gene symbol

LPHN1

LGALS4

Gene ID

22859

3960

Gene nameadhesion G protein-coupled receptor L1galectin 4
SynonymsCIRL1|CL1|LEC2|LPHN1GAL4|L36LBP
Cytomap

19p13.12

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionadhesion G protein-coupled receptor L1CIRL-1calcium-independent alpha-latrotoxin receptor 1latrophilin-1lectomedin-2galectin-4L-36 lactose-binding proteinantigen NY-CO-27gal-4lactose-binding lectin 4lectin, galactoside-binding, soluble, 4
Modification date2020031320200313
UniProtAcc.

P56470

Ensembl transtripts involved in fusion geneENST00000340736, ENST00000361434, 
ENST00000591528, 		ENST00000597803, 
ENST00000307751, 
Fusion gene scores* DoF score4 X 5 X 4=808 X 6 X 4=192
# samples 710
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LPHN1 [Title/Abstract] AND LGALS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPHN1(14281519)-LGALS4(39303781), # samples:1
LPHN1(14288343)-LGALS4(39299588), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LPHN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LGALS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A891-01ALPHN1chr19

14288343

-LGALS4chr19

39299588

-
ChimerDB4ESCATCGA-L5-A891LPHN1chr19

14281519

-LGALS4chr19

39303781

-


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Fusion Gene ORF analysis for LPHN1-LGALS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000340736ENST00000597803LPHN1chr19

14288343

-LGALS4chr19

39299588

-
5CDS-intronENST00000361434ENST00000597803LPHN1chr19

14288343

-LGALS4chr19

39299588

-
In-frameENST00000340736ENST00000307751LPHN1chr19

14288343

-LGALS4chr19

39299588

-
In-frameENST00000361434ENST00000307751LPHN1chr19

14288343

-LGALS4chr19

39299588

-
intron-3CDSENST00000591528ENST00000307751LPHN1chr19

14288343

-LGALS4chr19

39299588

-
intron-5UTRENST00000340736ENST00000307751LPHN1chr19

14281519

-LGALS4chr19

39303781

-
intron-5UTRENST00000361434ENST00000307751LPHN1chr19

14281519

-LGALS4chr19

39303781

-
intron-5UTRENST00000591528ENST00000307751LPHN1chr19

14281519

-LGALS4chr19

39303781

-
intron-intronENST00000340736ENST00000597803LPHN1chr19

14281519

-LGALS4chr19

39303781

-
intron-intronENST00000361434ENST00000597803LPHN1chr19

14281519

-LGALS4chr19

39303781

-
intron-intronENST00000591528ENST00000597803LPHN1chr19

14288343

-LGALS4chr19

39299588

-
intron-intronENST00000591528ENST00000597803LPHN1chr19

14281519

-LGALS4chr19

39303781

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340736LPHN1chr1914288343-ENST00000307751LGALS4chr1939299588-1505582251419464
ENST00000361434LPHN1chr1914288343-ENST00000307751LGALS4chr1939299588-148756471401464

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340736ENST00000307751LPHN1chr1914288343-LGALS4chr1939299588-0.0052045350.9947955
ENST00000361434ENST00000307751LPHN1chr1914288343-LGALS4chr1939299588-0.0055420270.99445796

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Fusion Genomic Features for LPHN1-LGALS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LPHN1-LGALS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:14281519/chr19:39303781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LGALS4

P56470

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLGALS4chr19:14288343chr19:39299588ENST00000307751110194_32344324.0DomainGalectin 2
TgeneLGALS4chr19:14288343chr19:39299588ENST00000307751110256_26244324.0RegionBeta-galactoside binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241303_1314941475.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241315_1318941475.0Compositional biasNote=Poly-Gly
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241410_1420941475.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324413_416941475.0Compositional biasNote=Poly-Thr
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231303_1314941470.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231315_1318941470.0Compositional biasNote=Poly-Gly
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231410_1420941470.0Compositional biasNote=Poly-Pro
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323413_416941470.0Compositional biasNote=Poly-Thr
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324139_398941475.0DomainOlfactomedin-like
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-32440_129941475.0DomainSUEL-type lectin
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324799_850941475.0DomainGPS
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323139_398941470.0DomainOlfactomedin-like
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-32340_129941470.0DomainSUEL-type lectin
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323799_850941470.0DomainGPS
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324117_120941475.0RegionCarbohydrate binding
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323117_120941470.0RegionCarbohydrate binding
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241024_1050941475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241072_1075941475.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241097_1474941475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-32425_858941475.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324880_893941475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324915_920941475.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324942_964941475.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324986_1002941475.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231024_1050941470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231072_1075941470.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231097_1474941470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-32325_858941470.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323880_893941470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323915_920941470.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323942_964941470.0Topological domainCytoplasmic
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323986_1002941470.0Topological domainExtracellular
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241003_1023941475.0TransmembraneHelical%3B Name%3D5
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241051_1071941475.0TransmembraneHelical%3B Name%3D6
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-3241076_1096941475.0TransmembraneHelical%3B Name%3D7
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324859_879941475.0TransmembraneHelical%3B Name%3D1
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324894_914941475.0TransmembraneHelical%3B Name%3D2
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324921_941941475.0TransmembraneHelical%3B Name%3D3
HgeneLPHN1chr19:14288343chr19:39299588ENST00000340736-324965_985941475.0TransmembraneHelical%3B Name%3D4
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231003_1023941470.0TransmembraneHelical%3B Name%3D5
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231051_1071941470.0TransmembraneHelical%3B Name%3D6
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-3231076_1096941470.0TransmembraneHelical%3B Name%3D7
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323859_879941470.0TransmembraneHelical%3B Name%3D1
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323894_914941470.0TransmembraneHelical%3B Name%3D2
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323921_941941470.0TransmembraneHelical%3B Name%3D3
HgeneLPHN1chr19:14288343chr19:39299588ENST00000361434-323965_985941470.0TransmembraneHelical%3B Name%3D4
TgeneLGALS4chr19:14288343chr19:39299588ENST0000030775111019_15044324.0DomainGalectin 1


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Fusion Gene Sequence for LPHN1-LGALS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49520_49520_1_LPHN1-LGALS4_LPHN1_chr19_14288343_ENST00000340736_LGALS4_chr19_39299588_ENST00000307751_length(transcript)=1505nt_BP=582nt
TCTTTTTTTTTTTTTTTCCTAATTTTTGGTCGGCGGCGGTGCTGGGCCAGGGGAAGGAAGGGACACGGAGGCCGCCCTCGTCCCGCCACC
TCCTACCCGCTTCCCCCCAGCCCCGGCTCCGGGAGATGTGCCGGGCGGGGGGCCCGGGTTCGCCGAGCCGCAGGAGAGACACGCTGGGCC
GACCCCAGAGAGGCGCTGGACAGGCTGGTGGTCCAGGCCGTGGTGCCTGCCAGGTGATGTGGGGCAAAGCCCCCCGCACAGGCCACTGAG
AGCTCCGGACACGCACCCGGCTGCCACCATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGC
CACCCAAGGCCTGAGCCGGGCCGGGCTCCCGTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCC
CGGCAGCGACGTCATCATGGTGGAGAATGCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGT
GCAGTGCTACCTGCCGGACGCCTTCAAGATCATGTCACAGAGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTCGC
CTTCCACTTCAATCCGCGGTTTGACGGCTGGGACAAGGTGGTCTTCAACACGTTGCAGGGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAG
GAGCATGCCCTTCAAAAAGGGTGCCGCCTTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCCTT
CTATGAGTACGGGCACCGGCTTCCCCTACAGATGGTCACCCACCTGCAAGTGGATGGGGATCTGCAACTTCAATCAATCAACTTCATCGG
AGGCCAGCCCCTCCGGCCCCAGGGACCCCCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCCAC
CATGGAAGGACCCCCAACCTTCAACCCGCCTGTGCCATATTTCGGGAGGCTGCAAGGAGGGCTCACAGCTCGAAGAACCATCATCATCAA
GGGCTATGTGCCTCCCACAGGCAAGAGCTTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGCAT
GGGCAACGGTACCGTGGTCCGGAACAGCCTTCTGAATGGCTCGTGGGGATCCGAGGAGAAGAAGATCACCCACAACCCATTTGGTCCCGG
ACAGTTCTTTGATCTGTCCATTCGCTGTGGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGCCT
CTCGGCCTTCCAGAGGGTGGACACATTGGAAATCCAGGGTGATGTCACCTTGTCCTATGTCCAGATCTAATCTATTCCTGGGGCCATAAC

>49520_49520_1_LPHN1-LGALS4_LPHN1_chr19_14288343_ENST00000340736_LGALS4_chr19_39299588_ENST00000307751_length(amino acids)=464AA_BP=185
MVGGGAGPGEGRDTEAALVPPPPTRFPPAPAPGDVPGGGPGFAEPQERHAGPTPERRWTGWWSRPWCLPGDVGQSPPHRPLRAPDTHPAA
TMARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAF
KIMSQRFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNPFYEYGHRLP
LQMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGK
SFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDT

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>49520_49520_2_LPHN1-LGALS4_LPHN1_chr19_14288343_ENST00000361434_LGALS4_chr19_39299588_ENST00000307751_length(transcript)=1487nt_BP=564nt
CTAATTTTTGGTCGGCGGCGGTGCTGGGCCAGGGGAAGGAAGGGACACGGAGGCCGCCCTCGTCCCGCCACCTCCTACCCGCTTCCCCCC
AGCCCCGGCTCCGGGAGATGTGCCGGGCGGGGGGCCCGGGTTCGCCGAGCCGCAGGAGAGACACGCTGGGCCGACCCCAGAGAGGCGCTG
GACAGGCTGGTGGTCCAGGCCGTGGTGCCTGCCAGGTGATGTGGGGCAAAGCCCCCCGCACAGGCCACTGAGAGCTCCGGACACGCACCC
GGCTGCCACCATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCGGCCACCCAAGGCCTGAGCCG
GGCCGGGCTCCCGTTCGGGCTGATGCGCCGGGAGCTGGCGTGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCAT
GGTGGAGAATGCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAATGTGCAGTGCTACCTGCCGGA
CGCCTTCAAGATCATGTCACAGAGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTCGCCTTCCACTTCAATCCGCG
GTTTGACGGCTGGGACAAGGTGGTCTTCAACACGTTGCAGGGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAGGAGCATGCCCTTCAAAAA
GGGTGCCGCCTTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCCTTCTATGAGTACGGGCACCG
GCTTCCCCTACAGATGGTCACCCACCTGCAAGTGGATGGGGATCTGCAACTTCAATCAATCAACTTCATCGGAGGCCAGCCCCTCCGGCC
CCAGGGACCCCCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCCACCATGGAAGGACCCCCAAC
CTTCAACCCGCCTGTGCCATATTTCGGGAGGCTGCAAGGAGGGCTCACAGCTCGAAGAACCATCATCATCAAGGGCTATGTGCCTCCCAC
AGGCAAGAGCTTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGCATGGGCAACGGTACCGTGGT
CCGGAACAGCCTTCTGAATGGCTCGTGGGGATCCGAGGAGAAGAAGATCACCCACAACCCATTTGGTCCCGGACAGTTCTTTGATCTGTC
CATTCGCTGTGGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGCCTCTCGGCCTTCCAGAGGGT
GGACACATTGGAAATCCAGGGTGATGTCACCTTGTCCTATGTCCAGATCTAATCTATTCCTGGGGCCATAACTCATGGGAAAACAGAATT

>49520_49520_2_LPHN1-LGALS4_LPHN1_chr19_14288343_ENST00000361434_LGALS4_chr19_39299588_ENST00000307751_length(amino acids)=464AA_BP=185
MVGGGAGPGEGRDTEAALVPPPPTRFPPAPAPGDVPGGGPGFAEPQERHAGPTPERRWTGWWSRPWCLPGDVGQSPPHRPLRAPDTHPAA
TMARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAF
KIMSQRFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNPFYEYGHRLP
LQMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGK
SFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDT

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Fusion Gene PPI Analysis for LPHN1-LGALS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LPHN1-LGALS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LPHN1-LGALS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource