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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LPP-HRASLS (FusionGDB2 ID:49565)

Fusion Gene Summary for LPP-HRASLS

check button Fusion gene summary
Fusion gene informationFusion gene name: LPP-HRASLS
Fusion gene ID: 49565
HgeneTgene
Gene symbol

LPP

HRASLS

Gene ID

4026

57110

Gene nameLIM domain containing preferred translocation partner in lipomaphospholipase A and acyltransferase 1
Synonyms-A-C1|H-REV107|HRASLS|HRASLS1|HRSL1|HSD28|PLA/AT1|PLAAT-1
Cytomap

3q27.3-q28

3q29

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnerphospholipase A and acyltransferase 1H-REV107 protein-related proteinHRAS like suppressorHRAS-like suppressor 1phospholipase Aphospholipase A/acyltransferase 1phospholipid-metabolizing enzyme A-C1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312675, ENST00000448637, 
ENST00000543006, ENST00000471917, 
ENST00000264735, ENST00000602513, 
Fusion gene scores* DoF score41 X 30 X 15=184501 X 1 X 1=1
# samples 521
** MAII scorelog2(52/18450*10)=-5.14896538280667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: LPP [Title/Abstract] AND HRASLS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPP(188202492)-HRASLS(192973440), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHRASLS

GO:0046470

phosphatidylcholine metabolic process

21880860

TgeneHRASLS

GO:0070292

N-acylphosphatidylethanolamine metabolic process

22825852|27623847


check buttonFusion gene breakpoints across LPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HRASLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-SI-AA8B-01ALPPchr3

188202492

-HRASLSchr3

192973440

+


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Fusion Gene ORF analysis for LPP-HRASLS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000312675ENST00000264735LPPchr3

188202492

-HRASLSchr3

192973440

+
In-frameENST00000312675ENST00000602513LPPchr3

188202492

-HRASLSchr3

192973440

+
In-frameENST00000448637ENST00000264735LPPchr3

188202492

-HRASLSchr3

192973440

+
In-frameENST00000448637ENST00000602513LPPchr3

188202492

-HRASLSchr3

192973440

+
In-frameENST00000543006ENST00000264735LPPchr3

188202492

-HRASLSchr3

192973440

+
In-frameENST00000543006ENST00000602513LPPchr3

188202492

-HRASLSchr3

192973440

+
intron-3CDSENST00000471917ENST00000264735LPPchr3

188202492

-HRASLSchr3

192973440

+
intron-3CDSENST00000471917ENST00000602513LPPchr3

188202492

-HRASLSchr3

192973440

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448637LPPchr3188202492-ENST00000602513HRASLSchr3192973440+110845292958288
ENST00000448637LPPchr3188202492-ENST00000264735HRASLSchr3192973440+110945292958288
ENST00000312675LPPchr3188202492-ENST00000602513HRASLSchr3192973440+12085521231058311
ENST00000312675LPPchr3188202492-ENST00000264735HRASLSchr3192973440+12095521231058311
ENST00000543006LPPchr3188202492-ENST00000602513HRASLSchr3192973440+115149591001330
ENST00000543006LPPchr3188202492-ENST00000264735HRASLSchr3192973440+115249591001330

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448637ENST00000602513LPPchr3188202492-HRASLSchr3192973440+0.0025935480.9974064
ENST00000448637ENST00000264735LPPchr3188202492-HRASLSchr3192973440+0.0025873540.9974126
ENST00000312675ENST00000602513LPPchr3188202492-HRASLSchr3192973440+0.0020778410.99792224
ENST00000312675ENST00000264735LPPchr3188202492-HRASLSchr3192973440+0.0020516850.99794835
ENST00000543006ENST00000602513LPPchr3188202492-HRASLSchr3192973440+0.0028536190.9971464
ENST00000543006ENST00000264735LPPchr3188202492-HRASLSchr3192973440+0.0028304320.99716955

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Fusion Genomic Features for LPP-HRASLS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LPP-HRASLS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:188202492/chr3:192973440)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHRASLSchr3:188202492chr3:192973440ENST000006025130420_1350169.0DomainLRAT
TgeneHRASLSchr3:188202492chr3:192973440ENST0000060251304160_1680169.0Topological domainLumenal
TgeneHRASLSchr3:188202492chr3:192973440ENST00000602513041_1380169.0Topological domainCytoplasmic
TgeneHRASLSchr3:188202492chr3:192973440ENST0000060251304139_1590169.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188202492chr3:192973440ENST00000312675-41141_370102613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188202492chr3:192973440ENST00000543006-41141_370102613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188202492chr3:192973440ENST00000312675-411414_473102613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188202492chr3:192973440ENST00000312675-411474_534102613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188202492chr3:192973440ENST00000312675-411535_603102613.0DomainLIM zinc-binding 3
HgeneLPPchr3:188202492chr3:192973440ENST00000543006-411414_473102613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188202492chr3:192973440ENST00000543006-411474_534102613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188202492chr3:192973440ENST00000543006-411535_603102613.0DomainLIM zinc-binding 3


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Fusion Gene Sequence for LPP-HRASLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49565_49565_1_LPP-HRASLS_LPP_chr3_188202492_ENST00000312675_HRASLS_chr3_192973440_ENST00000264735_length(transcript)=1209nt_BP=552nt
GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA
TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT
GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA
CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA
CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT
CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT
TTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCT
GGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCC
AAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATAC
GATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTC
AACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTG
ACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTG
ATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGAT

>49565_49565_1_LPP-HRASLS_LPP_chr3_188202492_ENST00000312675_HRASLS_chr3_192973440_ENST00000264735_length(amino acids)=311AA_BP=142
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGD
GYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLR

--------------------------------------------------------------
>49565_49565_2_LPP-HRASLS_LPP_chr3_188202492_ENST00000312675_HRASLS_chr3_192973440_ENST00000602513_length(transcript)=1208nt_BP=552nt
GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA
TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT
GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA
CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA
CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT
CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT
TTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCT
GGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCC
AAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATAC
GATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTC
AACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTG
ACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTG
ATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGAT

>49565_49565_2_LPP-HRASLS_LPP_chr3_188202492_ENST00000312675_HRASLS_chr3_192973440_ENST00000602513_length(amino acids)=311AA_BP=142
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGD
GYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLR

--------------------------------------------------------------
>49565_49565_3_LPP-HRASLS_LPP_chr3_188202492_ENST00000448637_HRASLS_chr3_192973440_ENST00000264735_length(transcript)=1109nt_BP=452nt
ATTTCTCTTCCGAGAGCTTCAGTTTCCTCACGTGCCAAGCGGACGGGTTGGAAGTTGGTCTTTGCCAGCTCTGACACCTTCATTGCAGTT
GGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAGATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCA
CTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCAC
CCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCAC
CTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTAC
AGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGC
ACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTAT
TCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATACGATGAAACGT
ACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTG
AACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTG
TTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGG
AATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGATGGCAGACTCT

>49565_49565_3_LPP-HRASLS_LPP_chr3_188202492_ENST00000448637_HRASLS_chr3_192973440_ENST00000264735_length(amino acids)=288AA_BP=119
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVF
SSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAV

--------------------------------------------------------------
>49565_49565_4_LPP-HRASLS_LPP_chr3_188202492_ENST00000448637_HRASLS_chr3_192973440_ENST00000602513_length(transcript)=1108nt_BP=452nt
ATTTCTCTTCCGAGAGCTTCAGTTTCCTCACGTGCCAAGCGGACGGGTTGGAAGTTGGTCTTTGCCAGCTCTGACACCTTCATTGCAGTT
GGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAGATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCA
CTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCAC
CCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCAC
CTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTAC
AGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCCTGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGC
ACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCTGTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTAT
TCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTGGGAAATGACACATACAGAATAAACAATAAATACGATGAAACGT
ACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTAATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTG
AACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAGGCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTG
TTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCAAAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGG
AATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGTGCATCATTACTGTTCCAGATTCCTATGATGGATGGCAGACTCT

>49565_49565_4_LPP-HRASLS_LPP_chr3_188202492_ENST00000448637_HRASLS_chr3_192973440_ENST00000602513_length(amino acids)=288AA_BP=119
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQMAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVF
SSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAV

--------------------------------------------------------------
>49565_49565_5_LPP-HRASLS_LPP_chr3_188202492_ENST00000543006_HRASLS_chr3_192973440_ENST00000264735_length(transcript)=1152nt_BP=495nt
GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC
GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG
ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT
TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA
TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC
TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCC
TGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCT
GTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTG
GGAAATGACACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTA
ATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAG
GCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCA
AAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGT

>49565_49565_5_LPP-HRASLS_LPP_chr3_188202492_ENST00000543006_HRASLS_chr3_192973440_ENST00000264735_length(amino acids)=330AA_BP=161
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQMAFNDCFSLNYPGNPCPG
DLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQ

--------------------------------------------------------------
>49565_49565_6_LPP-HRASLS_LPP_chr3_188202492_ENST00000543006_HRASLS_chr3_192973440_ENST00000602513_length(transcript)=1151nt_BP=495nt
GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC
GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG
ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT
TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA
TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC
TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGATGGCGTTTAATGATTGCTTCAGTTTGAACTACCCTGGCAACCCC
TGCCCAGGGGACTTGATCGAAGTGTTCCGTCCTGGCTATCAGCACTGGGCCCTGTACTTGGGTGATGGTTACGTTATCAACATAGCACCT
GTAGATGGCATTCCTGCGTCCTTTACAAGCGCCAAGTCTGTATTCAGCAGTAAGGCCCTGGTGAAAATGCAGCTCTTGAAGGATGTTGTG
GGAAATGACACATACAGAATAAACAATAAATACGATGAAACGTACCCCCCTCTCCCTGTGGAAGAAATCATAAAGCGGTCAGAGTTTGTA
ATTGGACAGGAGGTGGCCTATAACTTACTTGTCAACAACTGTGAACATTTTGTGACATTGCTTCGCTATGGAGAAGGAGTTTCAGAGCAG
GCCAACCGAGCGATAAGTACCGTTGAGTTTGTGACAGCTGCTGTTGGTGTCTTCTCATTCCTGGGCTTGTTTCCAAAAGGACAAAGAGCA
AAATACTATTAACAATTTACCAAAGAGATATTGATATTGAAGGAATTTGGGAGGAGGAAAAGAAACCTGGGGTGAATACTTATTTTCAGT

>49565_49565_6_LPP-HRASLS_LPP_chr3_188202492_ENST00000543006_HRASLS_chr3_192973440_ENST00000602513_length(amino acids)=330AA_BP=161
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQMAFNDCFSLNYPGNPCPG
DLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQ

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Fusion Gene PPI Analysis for LPP-HRASLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LPP-HRASLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LPP-HRASLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource