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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LPP-LEPREL1 (FusionGDB2 ID:49570)

Fusion Gene Summary for LPP-LEPREL1

check button Fusion gene summary
Fusion gene informationFusion gene name: LPP-LEPREL1
Fusion gene ID: 49570
HgeneTgene
Gene symbol

LPP

LEPREL1

Gene ID

4026

55214

Gene nameLIM domain containing preferred translocation partner in lipomaprolyl 3-hydroxylase 2
Synonyms-LEPREL1|MCVD|MLAT4
Cytomap

3q27.3-q28

3q28

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnerprolyl 3-hydroxylase 2leprecan-like 1myxoid liposarcoma-associated protein 4procollagen-proline 3-dioxygenase 2prolyl 3-hydroxylase 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000471917, ENST00000312675, 
ENST00000448637, ENST00000543006, 
ENST00000319332, ENST00000427335, 
Fusion gene scores* DoF score41 X 30 X 15=184505 X 3 X 5=75
# samples 526
** MAII scorelog2(52/18450*10)=-5.14896538280667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LPP [Title/Abstract] AND LEPREL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPP(188327632)-LEPREL1(189713231), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLEPREL1

GO:0008285

negative regulation of cell proliferation

19436308

TgeneLEPREL1

GO:0019511

peptidyl-proline hydroxylation

18487197

TgeneLEPREL1

GO:0032963

collagen metabolic process

18487197


check buttonFusion gene breakpoints across LPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LEPREL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6941-01ALPPchr3

188327632

-LEPREL1chr3

189713231

-
ChimerDB4HNSCTCGA-CV-6941LPPchr3

188327632

+LEPREL1chr3

189713231

-


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Fusion Gene ORF analysis for LPP-LEPREL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000471917ENST00000319332LPPchr3

188327632

+LEPREL1chr3

189713231

-
3UTR-5UTRENST00000471917ENST00000427335LPPchr3

188327632

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000312675ENST00000427335LPPchr3

188327632

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000448637ENST00000427335LPPchr3

188327632

+LEPREL1chr3

189713231

-
5CDS-5UTRENST00000543006ENST00000427335LPPchr3

188327632

+LEPREL1chr3

189713231

-
In-frameENST00000312675ENST00000319332LPPchr3

188327632

+LEPREL1chr3

189713231

-
In-frameENST00000448637ENST00000319332LPPchr3

188327632

+LEPREL1chr3

189713231

-
In-frameENST00000543006ENST00000319332LPPchr3

188327632

+LEPREL1chr3

189713231

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448637LPPchr3188327632+ENST00000319332LEPREL1chr3189713231-40901259922905937
ENST00000312675LPPchr3188327632+ENST00000319332LEPREL1chr3189713231-419013591233005960
ENST00000543006LPPchr3188327632+ENST00000319332LEPREL1chr3189713231-4133130292948979

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448637ENST00000319332LPPchr3188327632+LEPREL1chr3189713231-0.0015627150.9984372
ENST00000312675ENST00000319332LPPchr3188327632+LEPREL1chr3189713231-0.0011834060.9988166
ENST00000543006ENST00000319332LPPchr3188327632+LEPREL1chr3189713231-0.0015463590.9984536

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Fusion Genomic Features for LPP-LEPREL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LPP-LEPREL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:188327632/chr3:189713231)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188327632chr3:189713231ENST00000312675+61141_370371613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188327632chr3:189713231ENST00000543006+61141_370371613.0Compositional biasNote=Pro-rich
TgeneLEPREL1chr3:188327632chr3:189713231ENST00000319332015557_671160709.0DomainFe2OG dioxygenase
TgeneLEPREL1chr3:188327632chr3:189713231ENST00000319332015705_708160709.0MotifPrevents secretion from ER
TgeneLEPREL1chr3:188327632chr3:189713231ENST00000319332015210_243160709.0RepeatNote=TPR 3
TgeneLEPREL1chr3:188327632chr3:189713231ENST00000319332015306_339160709.0RepeatNote=TPR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188327632chr3:189713231ENST00000312675+611414_473371613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188327632chr3:189713231ENST00000312675+611474_534371613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188327632chr3:189713231ENST00000312675+611535_603371613.0DomainLIM zinc-binding 3
HgeneLPPchr3:188327632chr3:189713231ENST00000543006+611414_473371613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188327632chr3:189713231ENST00000543006+611474_534371613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188327632chr3:189713231ENST00000543006+611535_603371613.0DomainLIM zinc-binding 3
TgeneLEPREL1chr3:188327632chr3:189713231ENST0000031933201593_99160709.0Compositional biasNote=Poly-Pro
TgeneLEPREL1chr3:188327632chr3:189713231ENST00000319332015148_181160709.0RepeatNote=TPR 2
TgeneLEPREL1chr3:188327632chr3:189713231ENST0000031933201544_77160709.0RepeatNote=TPR 1


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Fusion Gene Sequence for LPP-LEPREL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49570_49570_1_LPP-LEPREL1_LPP_chr3_188327632_ENST00000312675_LEPREL1_chr3_189713231_ENST00000319332_length(transcript)=4190nt_BP=1359nt
GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA
TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT
GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA
CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA
CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT
CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT
TTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTGGACGCTGAGATTGACTCCTTGACCAGCATCTTG
GCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGTTCAACAGCCTCTCCTCCAGTTTCGACCCCAGTC
ACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAGTCTACATTGAAACCACAGCCTGCACCCCAGGCT
GGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCAGCCTCCTACACCACGGCCTCCACTTCTTCAAGG
CCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCCCCTTCATCAGGACAAATTTATGGCTCAGGGCCC
CAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACACGGGGAGGCATGGATTATGCCTACATTCCACCA
CCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTATGAAGGCTACTATGCAGCAGGGCCAGGCTATGGG
GGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAACGGGAACCAGGGTACACTCCTCCTGGAGCAGGG
AACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACAGATCCTGTTTCAGCCCCCTGTGCGCCACCATTG
CAGCCAAAGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAAC
ATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGA
GTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGC
CGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTAC
ATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTG
CACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCA
GATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGAT
TTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAAT
TATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATG
GGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAG
CAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATG
CTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCT
GGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATG
CTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCAT
CCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCT
CTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAA
TGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTG
TGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAG
CATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGA
ACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGT
TGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCAT
GTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGC
CTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAG
TTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGA
ATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTC
TGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGC
AGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGA
CTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCC
ACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACT
TTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGT
ACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACA

>49570_49570_1_LPP-LEPREL1_LPP_chr3_188327632_ENST00000312675_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=960AA_BP=412
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKP
RPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQ
PSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQ
QGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVE
ALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECV
RELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLE
SELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLD
NVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTH
MVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGG

--------------------------------------------------------------
>49570_49570_2_LPP-LEPREL1_LPP_chr3_188327632_ENST00000448637_LEPREL1_chr3_189713231_ENST00000319332_length(transcript)=4090nt_BP=1259nt
ATTTCTCTTCCGAGAGCTTCAGTTTCCTCACGTGCCAAGCGGACGGGTTGGAAGTTGGTCTTTGCCAGCTCTGACACCTTCATTGCAGTT
GGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAGATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCA
CTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCAC
CCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCAC
CTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTAC
AGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTGGACGCTGAGATTGACTCCTTGACCAGCATCTTGGCTGACCTTG
AGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGTTCAACAGCCTCTCCTCCAGTTTCGACCCCAGTCACAGGACACA
AGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAGTCTACATTGAAACCACAGCCTGCACCCCAGGCTGGACCCATCC
CTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCAGCCTCCTACACCACGGCCTCCACTTCTTCAAGGCCTACCTTTA
ATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCCCCTTCATCAGGACAAATTTATGGCTCAGGGCCCCAGGGCTATA
ACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACACGGGGAGGCATGGATTATGCCTACATTCCACCACCAGGACTTC
AGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTATGAAGGCTACTATGCAGCAGGGCCAGGCTATGGGGGCAGAAATG
ACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAACGGGAACCAGGGTACACTCCTCCTGGAGCAGGGAACCAGAACC
CTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACAGATCCTGTTTCAGCCCCCTGTGCGCCACCATTGCAGCCAAAGC
TTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATT
ACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATT
ATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTAT
GTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGC
TTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATT
ACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGG
ATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGT
TTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCA
GATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGC
TATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACG
GGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTG
ATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAG
GTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAA
CTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATG
CTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATA
TGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCA
TGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCT
TGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGA
ATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTAT
TTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATC
TATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGG
ATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGA
GCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCT
CCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCT
TGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTC
AGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACG
CTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTT
TCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCC
AGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAA
CTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAA
GAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACACAGATTTGTG

>49570_49570_2_LPP-LEPREL1_LPP_chr3_188327632_ENST00000448637_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=937AA_BP=389
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHK
RMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYN
TQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNP
PGMYPVTGPKKTYITDPVSAPCAPPLQPKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHY
EADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDY
LQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIR
YGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGD
GYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHA
DNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTL

--------------------------------------------------------------
>49570_49570_3_LPP-LEPREL1_LPP_chr3_188327632_ENST00000543006_LEPREL1_chr3_189713231_ENST00000319332_length(transcript)=4133nt_BP=1302nt
GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC
GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG
ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT
TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA
TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC
TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTG
GACGCTGAGATTGACTCCTTGACCAGCATCTTGGCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGT
TCAACAGCCTCTCCTCCAGTTTCGACCCCAGTCACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAG
TCTACATTGAAACCACAGCCTGCACCCCAGGCTGGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCA
GCCTCCTACACCACGGCCTCCACTTCTTCAAGGCCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCC
CCTTCATCAGGACAAATTTATGGCTCAGGGCCCCAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACA
CGGGGAGGCATGGATTATGCCTACATTCCACCACCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTAT
GAAGGCTACTATGCAGCAGGGCCAGGCTATGGGGGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAA
CGGGAACCAGGGTACACTCCTCCTGGAGCAGGGAACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACA
GATCCTGTTTCAGCCCCCTGTGCGCCACCATTGCAGCCAAAGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTG
GCTAACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAA
GCCAAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCC
TTAAGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAG
GCTGGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGC
CGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTG
GAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGC
ATTGACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCA
GAAGGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAAC
GTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTC
TATGAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGC
CGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTT
GAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAA
AAGGCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCT
GGTCAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAG
CCTCCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGAT
GCTAAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCA
GTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTG
ATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTAT
CAAATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATC
AGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCT
CTCTCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGC
CTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGT
TTTTCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAA
TTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAA
CCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAG
TGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGAT
CTCATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAA
TAAACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAG
GTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGG
AGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTT

>49570_49570_3_LPP-LEPREL1_LPP_chr3_188327632_ENST00000543006_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=979AA_BP=431
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASY
TTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKLNQLEKAVEAAHTFFVANP
EHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGL
YEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDP
ASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYEN
ITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKAR
RIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LPP-LEPREL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LPP-LEPREL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LPP-LEPREL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource