FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LPP-SEC62 (FusionGDB2 ID:49581)

Fusion Gene Summary for LPP-SEC62

check button Fusion gene summary
Fusion gene informationFusion gene name: LPP-SEC62
Fusion gene ID: 49581
HgeneTgene
Gene symbol

LPP

SEC62

Gene ID

4026

7095

Gene nameLIM domain containing preferred translocation partner in lipomaSEC62 homolog, preprotein translocation factor
Synonyms-Dtrp1|HTP1|TLOC1|TP-1
Cytomap

3q27.3-q28

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnertranslocation protein SEC62SEC62 preprotein translocation factorhTP-1membrane protein SEC62, S.cerevisiae, homolog oftranslocation protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000471917, ENST00000312675, 
ENST00000448637, ENST00000543006, 
ENST00000337002, ENST00000480708, 
ENST00000470355, 
Fusion gene scores* DoF score41 X 30 X 15=1845017 X 20 X 8=2720
# samples 5225
** MAII scorelog2(52/18450*10)=-5.14896538280667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2720*10)=-3.44360665147561
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LPP [Title/Abstract] AND SEC62 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPP(188327632)-SEC62(169693396), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEC62 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-94-8035-01ALPPchr3

188327632

+SEC62chr3

169693396

+


Top

Fusion Gene ORF analysis for LPP-SEC62

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000471917ENST00000337002LPPchr3

188327632

+SEC62chr3

169693396

+
3UTR-3CDSENST00000471917ENST00000480708LPPchr3

188327632

+SEC62chr3

169693396

+
3UTR-intronENST00000471917ENST00000470355LPPchr3

188327632

+SEC62chr3

169693396

+
5CDS-intronENST00000312675ENST00000470355LPPchr3

188327632

+SEC62chr3

169693396

+
5CDS-intronENST00000448637ENST00000470355LPPchr3

188327632

+SEC62chr3

169693396

+
5CDS-intronENST00000543006ENST00000470355LPPchr3

188327632

+SEC62chr3

169693396

+
In-frameENST00000312675ENST00000337002LPPchr3

188327632

+SEC62chr3

169693396

+
In-frameENST00000312675ENST00000480708LPPchr3

188327632

+SEC62chr3

169693396

+
In-frameENST00000448637ENST00000337002LPPchr3

188327632

+SEC62chr3

169693396

+
In-frameENST00000448637ENST00000480708LPPchr3

188327632

+SEC62chr3

169693396

+
In-frameENST00000543006ENST00000337002LPPchr3

188327632

+SEC62chr3

169693396

+
In-frameENST00000543006ENST00000480708LPPchr3

188327632

+SEC62chr3

169693396

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448637LPPchr3188327632+ENST00000337002SEC62chr3169693396+77331259922422776
ENST00000448637LPPchr3188327632+ENST00000480708SEC62chr3169693396+26381259922422776
ENST00000312675LPPchr3188327632+ENST00000337002SEC62chr3169693396+783313591232522799
ENST00000312675LPPchr3188327632+ENST00000480708SEC62chr3169693396+273813591232522799
ENST00000543006LPPchr3188327632+ENST00000337002SEC62chr3169693396+7776130292465818
ENST00000543006LPPchr3188327632+ENST00000480708SEC62chr3169693396+2681130292465818

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448637ENST00000337002LPPchr3188327632+SEC62chr3169693396+0.0006344330.9993656
ENST00000448637ENST00000480708LPPchr3188327632+SEC62chr3169693396+0.0028727480.99712723
ENST00000312675ENST00000337002LPPchr3188327632+SEC62chr3169693396+0.000565420.99943453
ENST00000312675ENST00000480708LPPchr3188327632+SEC62chr3169693396+0.0019779790.9980221
ENST00000543006ENST00000337002LPPchr3188327632+SEC62chr3169693396+0.0006397440.99936026
ENST00000543006ENST00000480708LPPchr3188327632+SEC62chr3169693396+0.0029409940.997059

Top

Fusion Genomic Features for LPP-SEC62


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LPPchr3188327632+SEC62chr3169693395+0.125408550.87459147
LPPchr3188327632+SEC62chr3169693395+0.125408550.87459147

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LPP-SEC62


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:188327632/chr3:169693396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188327632chr3:169693396ENST00000312675+61141_370371613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188327632chr3:169693396ENST00000543006+61141_370371613.0Compositional biasNote=Pro-rich
TgeneSEC62chr3:188327632chr3:169693396ENST0000033700208218_23412400.0Topological domainLumenal
TgeneSEC62chr3:188327632chr3:169693396ENST0000033700208256_39912400.0Topological domainCytoplasmic
TgeneSEC62chr3:188327632chr3:169693396ENST0000048070809218_23412442.0Topological domainLumenal
TgeneSEC62chr3:188327632chr3:169693396ENST0000048070809256_39912442.0Topological domainCytoplasmic
TgeneSEC62chr3:188327632chr3:169693396ENST0000033700208197_21712400.0TransmembraneHelical
TgeneSEC62chr3:188327632chr3:169693396ENST0000033700208235_25512400.0TransmembraneHelical
TgeneSEC62chr3:188327632chr3:169693396ENST0000048070809197_21712442.0TransmembraneHelical
TgeneSEC62chr3:188327632chr3:169693396ENST0000048070809235_25512442.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188327632chr3:169693396ENST00000312675+611414_473371613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188327632chr3:169693396ENST00000312675+611474_534371613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188327632chr3:169693396ENST00000312675+611535_603371613.0DomainLIM zinc-binding 3
HgeneLPPchr3:188327632chr3:169693396ENST00000543006+611414_473371613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188327632chr3:169693396ENST00000543006+611474_534371613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188327632chr3:169693396ENST00000543006+611535_603371613.0DomainLIM zinc-binding 3
TgeneSEC62chr3:188327632chr3:169693396ENST00000337002081_19612400.0Topological domainCytoplasmic
TgeneSEC62chr3:188327632chr3:169693396ENST00000480708091_19612442.0Topological domainCytoplasmic


Top

Fusion Gene Sequence for LPP-SEC62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49581_49581_1_LPP-SEC62_LPP_chr3_188327632_ENST00000312675_SEC62_chr3_169693396_ENST00000337002_length(transcript)=7833nt_BP=1359nt
GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA
TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT
GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA
CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA
CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT
CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT
TTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTGGACGCTGAGATTGACTCCTTGACCAGCATCTTG
GCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGTTCAACAGCCTCTCCTCCAGTTTCGACCCCAGTC
ACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAGTCTACATTGAAACCACAGCCTGCACCCCAGGCT
GGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCAGCCTCCTACACCACGGCCTCCACTTCTTCAAGG
CCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCCCCTTCATCAGGACAAATTTATGGCTCAGGGCCC
CAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACACGGGGAGGCATGGATTATGCCTACATTCCACCA
CCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTATGAAGGCTACTATGCAGCAGGGCCAGGCTATGGG
GGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAACGGGAACCAGGGTACACTCCTCCTGGAGCAGGG
AACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACAGATCCTGTTTCAGCCCCCTGTGCGCCACCATTG
CAGCCAAAGGAAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTTCGATTCAACTGTCCAACAAAGTCCACCAATATG
ATGGGTCACCGGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGATTCAAAGTGGGCAAAGGCCAAGAAAGGAGAGGAA
GCTTTATTTACAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAGCAGTTTTTTCACCGAGCCCTAAAAGTAATGAAA
ATGAAATATGATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGAAAAGAAGAAGATAAAAAGAGCAAGAAAGAAAAT
ATAAAGGATGAGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAAGAATCCAAAAAGGAGGAAACTCCAGGAACTCCT
AAAAAGAAGGAAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTTCTGGATGGAAATGAGGTGTATGTATGGATCTAT
GACCCAGTTCACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATAGCGGCCACCCTCTTCCCCCTTTGGCCAGCAGAA
ATGAGAGTAGGTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATTCTTCTCCTTGCTGTTGCTCGATGCATTCTATTT
CTCATCATTTGGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCATTGACTCCTTCAGG
CCTCTGTACACACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAACAGAAGTCCGACAGT
GAGGAAAAGTCAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCTCGGGGGGAGAACGG
CATTCAGACACGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAATGATAACAAAAGAG
GAACTGGAACAGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTTCACATGAAAAATCA
TAATCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGTTGGATTTTCTATGTTGGCTGATTACCATATTGAACACATGGCATTTG
TAGCATTCTTTAAATCTATCTACTGAAATGTATTTGACATTCAAGCAGTTATATTCGGTCCTTCATTTTATAGAATATTGGCACTATTAT
TGGTACAGTTTAAAGCCATTAATATGTTTTATCCATTTGATAATTTTACAGTAAGTAGGTCTCATTCATTTTGACAGTTATCAAAGATGT
ACTTTCCACAGTTAAATTTACATTAATGGCAATTTTTGATAGTTTTATGGCTTTTTACTGTTAGACTAATCAAAAATAACTTTAAAAGGA
ACAAAGAAACTCCAACATTTCACATTATGCATAGTTATGTAGCCATTTCACAGTTTCTTTAAGATGTGTAAACTCATTGTCCTTGATAGT
TTTTATTTTTCATTATAAAATTATACCAGGAGATTTCTTTTAAGATTCTGAGTTAGCAGAGTTCAAAACTATTTTGTGGAAACAAGCCAA
CTAGTAACAATGCAGCAACACTTCTGGTTTAGCTAAATTATTTTTCCAATGTAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAA
AGATGGTCGTCTCCAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTA
AAGTGTATTCTGTACATAATTTACAAATAAAACATTTTATTTTAATTGTTACTTATTATTTAGATATTTCTCAACACTTAAATTCATAAA
ATTAAGACCATGTAAGGGTATGTTTTTAGAGAAATGGAAGTTTGAGTAACCCACAGAACATCTGTGATCTTTCTACAGCAGCTTCAGTTT
TGTGCCAACATTCCATGTATTTTGAATATGAGCAAAAACTGATCTTAAGAGCAGACTTAAAGTAGCTTTGTACGCCTTAATGTTCATTTT
GATTTATTTTAAATCTTTACATTCAGAAATGAGATACTGTATTATCAGACCAGGAGGCATTGCTGTGAAAGATAATTTCCTATTCTAAAA
TATCAAATTTAAAATAAAGATAATGAAAGAAAACATAAGAGAACTATTGGACTCTAATTGCTTTGAACTAGTTTTGCAGTTTGACTTTAC
GTCTTATACATCTTAGTTACAAGTCTTTGGAAACTCTTGTTTACTTATGAGCATAATCATTCCTTGGAGTTATACTAACTAATAATGAAT
ATTAAATGATTTTTCTTCAGTCACAGTGAGAGCATCTTGCTTTGTGGTTGAAATAGGTAGTGTATGTCAGTCTTTGCTTTAGGCTGTTTC
TCATCTAAGTGTTTGAATTAAAGATGTTAAATTTTTCTAATTGTGAAAAATATGTTTTCTGTATCGACACATTTTATTAAACTTGGCTTG
ATTGCTTCTTTATAGTAGTCCCTGTAAGTGGACATAAATGTGGCTATTTGATGTTAATGCAACTATGTCAAGGCTGCAATCACTTTAATA
GTTTCTTTTTAGCAAATAAATGTTCATTGATGAAGTGCCTGGGTATTTTCCCGTCCCATTTGCAGAGCTCTACTACTTCATTTCCACAGT
AAGCATATATATAATGATCACTTCTGAGTTTATCACCAGTAACATTGATACCTATTTTGGGGTATAAACATGGTGTTTTTCAGAAATAAA
AATTATTTCATTAACCTTTACTATTACTGTGATAATACCCAGGCACTCAATATTCATCCTGAAATTTTTTATAATATATGTAATTTGTCT
AGTCTTAAAGACATTTGGAGCATGGCCAACAGGAAGGTCAGCTTCTTACTGATGTGTGTGGATTCTTACAGAATGTTAGTACAAATTTTT
ATAAATATTTGGTGATCCCTGGGGGGAAATATCATTCTTACTATGGTTAGAAAGTGAATTAGAAATTTCAGCTCAGTTTCTATTTTACTA
TTCAAGTTGTGTACTTTAAACAAATATAAAAATCAAAAGGCTGCCTCTATTACAATCCTCAGTGGAATAGATGGCTATCTTTCTTGGCTA
ACATTAAATATTCTTGTACCAGAGCATGGAAAATCGTTTATAATTGTTAATAGAATGGCGATTTTTTTTTAAGAACTTCAGATTTGCTAT
GCTGCTGTAAGTAGAAAGCATGAAGCTTTTTGATCATGTAGGGCTTATTGTAGAGGGTATCAATTGGCCTAACTAAGCAGGATTGAATTT
ACCAGAGGCTAAGTTCAGATAGTAAGAATAATGCATATGTGATTGTTCTTAAAGTCAATGTATTAAATAAGGTATTTTTCCTTTTCCCTC
TTACTGGATTTTTCAATTTTCAAACCATATGGCCTAGGTAACTTTAATTGAAATAATATAGATTTAGTTGAATACTATTCAGGAAGTAAT
AAATTTTAATATATCACATTGAAATTATGCAGTGGTGATGAATTTTGGTGTTTCCCCCCTCTTTCTGGTTTTACATCATGAGGATCAGTT
AGCTGCTGACAAGAAAAGTCATCTTGTGTCTTTTGTAAATTGAATTTTTTTTTTAAATCTATTAGGAACTGGAAAACAGCAAGTATGGTT
GATTCTCATTATTCAAGGTAGTTACGTTCTATAAAGTCACTGCGAACACTGAATTAGCAAATATAGAACCTAGGGGAAATACAAGGCTAG
ATTTCTGCAAGCCACTGGTCACATTTTCATCAAGCAGTCAACATGTAAATTTCTGTTGTAAAGACACCTTATTTAATATAATCGATTCAT
TAACATTGAAGTCATGACCAACAACACTGTAACTCATGCCTGAATGAAGCTTATCTGACACATAAGCTTCATAAGGCACACAACAGCCTT
TTTACCCTTAGGAACAGCTTTTTGCCCTTAGCACTATGCTTGGGGGCCATTTTAAACAGTGAAATCAAAAAAAGAACAGAAATGCAAAAA
CCATGGCATTAGCGTAAAAAGGACACGTTTATAGTATGAAAGCTGGAACATGGCCTTGTTCAACCTCAGCTCAGAATATGTGTACAGCAA
GTTTTTTGCTGTACCACAAAATTTTAGGTTAGGCAAATTCACAAATACGGAATCCATGAATAACGAGGATCAACTGTACTTAACTATATT
TTAAAGCTGTGACATTTATCTACCTGGTTTATGGAATAGAATTTATTGCTGAATCATGCTCCAGTATTTGAGTGATGTTTTAAATATCCT
ATGTCTGAAAATAATTCCTCCTAATTGTGTGGTAATTTGCTTTTACTGTTTCCACAGTATTTCAGGTCTTTGCTCATTCACTCAGTAATA
CTGAGCACTTACCATGTACCAGAATTTTACTAGGCACAACCATGAATAAAAATACAATTCTCTTGCACCATTAAATAGTGTGTTAAGTGC
TACGGCAGCAAATTGCTACATGTGCTGGATATCTCTTGTTTTCCCCTCCAGCTCCACTCTGCTCTTGCCCACAAAGCTGACCCGAATGGA
CCACAGCAGTGGGCTCCTATGCCTCCTGGCTTCTGAGTGGGTTTGGCCAAGGAGTGTCCTGGCCAGAGATCAGAGGATGGTAGGGTGCCT
ATTCTCGGCTCTTCTCCTGGGGTTGGGGGGCTGCCTTAGCAGCCAAAGGTCACTTCTCCCAAACTCCTTCCCTGCTTTCCAGGTTGCCAG
TCCCTGCACTCTTCCTTTCTGGCCAAGGATGATGTCAGTTCTGCTGCTACTAGCCTGGAGTTGCAGAAGCTACTGTGCTTCCTCTTTGGG
TAGCCTATACCTATACTTATCTCCTCATAATATCTTCATGTAAAGAACCATCTGTTTCTTATTGGAATCAAGACCAATACCAAGGAGAAA
TTCCTAGGGAACAAAAATTCCAATGAGGAATTGACCTCTTTGTCAGATCCTTATCACCAAACATTAGAAAAGATCTCATAACTTTATACA
GCATGTTGTAAGCATTTTGATAACTAAAATCCTGTTCTAGTGAATGTCATGCAGATAACTACACAAGGAGATTAATTTAAATTTGCCTTC
TTTGGCAAGCCCTTAAACCAATGGCTAAAGCAGTTAGTTGTGAGTTTCTGAGTAGGTCCCAATGCGTTTATTTCATTTGTCCAACCTAGC
ACAGAGATCCTTTGATACTTTAATTGCATGGCTTTTCCAATCAGACGAAATTTCAGTCTGAGAGAGGACATATTTTCTGAGGTTTATAGT
TTTAGGATTGTCCAAAAGGCCTATGATCTCTTCTTAGCATGACAGAAAGAGGGAAAGATAAGTTAAATTTCAAGGGGGTCATATCATCAC
ACTTTGGTCTTATTTCATTTTCAATGATTTCCTAGATCACTTTAACTTTTTTGTGTCATGGACTCCTCAGAATAATGGGTTTTTTTTGTT
TGTTTGTTTGTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGAAATCTCAGCTCACTGCAACCTCCGCCTCCTGA
GGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACATGCCACCACACCCAGCTAATTTTTGTATTTTTTAGT
AGAGACAGGGTTTCACCGTGTTGGCGAGACTGATCTTGAACTCCTGACATCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGAT
TACAGGCATGAGCCACCATGCCTGGCCAGAATAATGTTTTTAAATGCAGAAAAGGAAATGCATGGGGTTACAAGGGAAACGAATTACACT
GAAGTGTAAGCTACCAAATAATTTATGATGTGGTAGTTATAGGTGTGCATTTAATAGCCAGATCTACGAGTGGATGTAATAACTGCTATG
ATGTTGAAGTAGCATAAAACATATATTAGATATCTGCAACAACTGTGATGTAACATGAAAATACCTGATTTCTGTTGACAAAGTTACTGC
TAGTACAACTGTGGATTGTTGTCTGCACTCGTCATTGAAGGAAATACTAAATTTTAGTTTTAGGCTAGTGAAATTAAAGTTAATTTTTCC
CATCCAAGTTCATGTATCTTCTGAATTCTATCCGTGAATCCCTTAGAGGTCTGTGAATTGTAGGTTAAGAACCCCTGCCCTAGCTAATCA
GATCCACCAATGTTTCAAATAGGACTATAACTTATTCAAAGGCCAATGATACTTCGCATAATTCAATTTTAATATTATTCACATTTCATG
TCACAAATTTAGTAAGTTACATGTGTTATGTGATGTTTTGTTTTGATAGATTATATCTTACTCCTAAATAAAAAGTCAAGATTTTTGTAG

>49581_49581_1_LPP-SEC62_LPP_chr3_188327632_ENST00000312675_SEC62_chr3_169693396_ENST00000337002_length(amino acids)=799AA_BP=412
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKP
RPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQ
PSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQ
QGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIAS
KAVDCLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKE
KKKDGEKEESKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVG
AGCFVASILLLAVARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKED

--------------------------------------------------------------
>49581_49581_2_LPP-SEC62_LPP_chr3_188327632_ENST00000312675_SEC62_chr3_169693396_ENST00000480708_length(transcript)=2738nt_BP=1359nt
GTCACTTTTATTTGGGGGTGTGGACAGCTGCTTTCCCAGGGGAGTACTTCTTACAGTGGGATTTCAAGACAAGATCGGCCTGAAGAAAAA
TTATATTTGTATATTTTTTAAAAAGTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCT
GCTTTTTTCATTGTTCCACTGGACGCTCATCAGAGGGAAGATCTTTTTCCTCAATTGATTCCAACAATGTCTCACCCATCTTGGCTGCCA
CCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACA
CAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTT
CCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCT
TTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTGGACGCTGAGATTGACTCCTTGACCAGCATCTTG
GCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGTTCAACAGCCTCTCCTCCAGTTTCGACCCCAGTC
ACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAGTCTACATTGAAACCACAGCCTGCACCCCAGGCT
GGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCAGCCTCCTACACCACGGCCTCCACTTCTTCAAGG
CCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCCCCTTCATCAGGACAAATTTATGGCTCAGGGCCC
CAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACACGGGGAGGCATGGATTATGCCTACATTCCACCA
CCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTATGAAGGCTACTATGCAGCAGGGCCAGGCTATGGG
GGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAACGGGAACCAGGGTACACTCCTCCTGGAGCAGGG
AACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACAGATCCTGTTTCAGCCCCCTGTGCGCCACCATTG
CAGCCAAAGGAAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTTCGATTCAACTGTCCAACAAAGTCCACCAATATG
ATGGGTCACCGGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGATTCAAAGTGGGCAAAGGCCAAGAAAGGAGAGGAA
GCTTTATTTACAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAGCAGTTTTTTCACCGAGCCCTAAAAGTAATGAAA
ATGAAATATGATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGAAAAGAAGAAGATAAAAAGAGCAAGAAAGAAAAT
ATAAAGGATGAGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAAGAATCCAAAAAGGAGGAAACTCCAGGAACTCCT
AAAAAGAAGGAAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTTCTGGATGGAAATGAGGTGTATGTATGGATCTAT
GACCCAGTTCACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATAGCGGCCACCCTCTTCCCCCTTTGGCCAGCAGAA
ATGAGAGTAGGTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATTCTTCTCCTTGCTGTTGCTCGATGCATTCTATTT
CTCATCATTTGGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCATTGACTCCTTCAGG
CCTCTGTACACACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAACAGAAGTCCGACAGT
GAGGAAAAGTCAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCTCGGGGGGAGAACGG
CATTCAGACACGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAATGATAACAAAAGAG
GAACTGGAACAGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTTCACATGAAAAATCA
TAATCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGTCTC
CAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAGTGTATTCTGT

>49581_49581_2_LPP-SEC62_LPP_chr3_188327632_ENST00000312675_SEC62_chr3_169693396_ENST00000480708_length(amino acids)=799AA_BP=412
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKP
RPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQ
PSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQ
QGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIAS
KAVDCLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKE
KKKDGEKEESKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVG
AGCFVASILLLAVARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKED

--------------------------------------------------------------
>49581_49581_3_LPP-SEC62_LPP_chr3_188327632_ENST00000448637_SEC62_chr3_169693396_ENST00000337002_length(transcript)=7733nt_BP=1259nt
ATTTCTCTTCCGAGAGCTTCAGTTTCCTCACGTGCCAAGCGGACGGGTTGGAAGTTGGTCTTTGCCAGCTCTGACACCTTCATTGCAGTT
GGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAGATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCA
CTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCAC
CCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCAC
CTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTAC
AGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTGGACGCTGAGATTGACTCCTTGACCAGCATCTTGGCTGACCTTG
AGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGTTCAACAGCCTCTCCTCCAGTTTCGACCCCAGTCACAGGACACA
AGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAGTCTACATTGAAACCACAGCCTGCACCCCAGGCTGGACCCATCC
CTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCAGCCTCCTACACCACGGCCTCCACTTCTTCAAGGCCTACCTTTA
ATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCCCCTTCATCAGGACAAATTTATGGCTCAGGGCCCCAGGGCTATA
ACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACACGGGGAGGCATGGATTATGCCTACATTCCACCACCAGGACTTC
AGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTATGAAGGCTACTATGCAGCAGGGCCAGGCTATGGGGGCAGAAATG
ACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAACGGGAACCAGGGTACACTCCTCCTGGAGCAGGGAACCAGAACC
CTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACAGATCCTGTTTCAGCCCCCTGTGCGCCACCATTGCAGCCAAAGG
AAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTTCGATTCAACTGTCCAACAAAGTCCACCAATATGATGGGTCACC
GGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGATTCAAAGTGGGCAAAGGCCAAGAAAGGAGAGGAAGCTTTATTTA
CAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAGCAGTTTTTTCACCGAGCCCTAAAAGTAATGAAAATGAAATATG
ATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGAAAAGAAGAAGATAAAAAGAGCAAGAAAGAAAATATAAAGGATG
AGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAAGAATCCAAAAAGGAGGAAACTCCAGGAACTCCTAAAAAGAAGG
AAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTTCTGGATGGAAATGAGGTGTATGTATGGATCTATGACCCAGTTC
ACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATAGCGGCCACCCTCTTCCCCCTTTGGCCAGCAGAAATGAGAGTAG
GTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATTCTTCTCCTTGCTGTTGCTCGATGCATTCTATTTCTCATCATTT
GGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCATTGACTCCTTCAGGCCTCTGTACA
CACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAACAGAAGTCCGACAGTGAGGAAAAGT
CAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCTCGGGGGGAGAACGGCATTCAGACA
CGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAATGATAACAAAAGAGGAACTGGAAC
AGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTTCACATGAAAAATCATAATCTGACT
AATTTTGGGACTGAATGAATAAGTACAAGAGGTTGGATTTTCTATGTTGGCTGATTACCATATTGAACACATGGCATTTGTAGCATTCTT
TAAATCTATCTACTGAAATGTATTTGACATTCAAGCAGTTATATTCGGTCCTTCATTTTATAGAATATTGGCACTATTATTGGTACAGTT
TAAAGCCATTAATATGTTTTATCCATTTGATAATTTTACAGTAAGTAGGTCTCATTCATTTTGACAGTTATCAAAGATGTACTTTCCACA
GTTAAATTTACATTAATGGCAATTTTTGATAGTTTTATGGCTTTTTACTGTTAGACTAATCAAAAATAACTTTAAAAGGAACAAAGAAAC
TCCAACATTTCACATTATGCATAGTTATGTAGCCATTTCACAGTTTCTTTAAGATGTGTAAACTCATTGTCCTTGATAGTTTTTATTTTT
CATTATAAAATTATACCAGGAGATTTCTTTTAAGATTCTGAGTTAGCAGAGTTCAAAACTATTTTGTGGAAACAAGCCAACTAGTAACAA
TGCAGCAACACTTCTGGTTTAGCTAAATTATTTTTCCAATGTAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGT
CTCCAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAGTGTATTC
TGTACATAATTTACAAATAAAACATTTTATTTTAATTGTTACTTATTATTTAGATATTTCTCAACACTTAAATTCATAAAATTAAGACCA
TGTAAGGGTATGTTTTTAGAGAAATGGAAGTTTGAGTAACCCACAGAACATCTGTGATCTTTCTACAGCAGCTTCAGTTTTGTGCCAACA
TTCCATGTATTTTGAATATGAGCAAAAACTGATCTTAAGAGCAGACTTAAAGTAGCTTTGTACGCCTTAATGTTCATTTTGATTTATTTT
AAATCTTTACATTCAGAAATGAGATACTGTATTATCAGACCAGGAGGCATTGCTGTGAAAGATAATTTCCTATTCTAAAATATCAAATTT
AAAATAAAGATAATGAAAGAAAACATAAGAGAACTATTGGACTCTAATTGCTTTGAACTAGTTTTGCAGTTTGACTTTACGTCTTATACA
TCTTAGTTACAAGTCTTTGGAAACTCTTGTTTACTTATGAGCATAATCATTCCTTGGAGTTATACTAACTAATAATGAATATTAAATGAT
TTTTCTTCAGTCACAGTGAGAGCATCTTGCTTTGTGGTTGAAATAGGTAGTGTATGTCAGTCTTTGCTTTAGGCTGTTTCTCATCTAAGT
GTTTGAATTAAAGATGTTAAATTTTTCTAATTGTGAAAAATATGTTTTCTGTATCGACACATTTTATTAAACTTGGCTTGATTGCTTCTT
TATAGTAGTCCCTGTAAGTGGACATAAATGTGGCTATTTGATGTTAATGCAACTATGTCAAGGCTGCAATCACTTTAATAGTTTCTTTTT
AGCAAATAAATGTTCATTGATGAAGTGCCTGGGTATTTTCCCGTCCCATTTGCAGAGCTCTACTACTTCATTTCCACAGTAAGCATATAT
ATAATGATCACTTCTGAGTTTATCACCAGTAACATTGATACCTATTTTGGGGTATAAACATGGTGTTTTTCAGAAATAAAAATTATTTCA
TTAACCTTTACTATTACTGTGATAATACCCAGGCACTCAATATTCATCCTGAAATTTTTTATAATATATGTAATTTGTCTAGTCTTAAAG
ACATTTGGAGCATGGCCAACAGGAAGGTCAGCTTCTTACTGATGTGTGTGGATTCTTACAGAATGTTAGTACAAATTTTTATAAATATTT
GGTGATCCCTGGGGGGAAATATCATTCTTACTATGGTTAGAAAGTGAATTAGAAATTTCAGCTCAGTTTCTATTTTACTATTCAAGTTGT
GTACTTTAAACAAATATAAAAATCAAAAGGCTGCCTCTATTACAATCCTCAGTGGAATAGATGGCTATCTTTCTTGGCTAACATTAAATA
TTCTTGTACCAGAGCATGGAAAATCGTTTATAATTGTTAATAGAATGGCGATTTTTTTTTAAGAACTTCAGATTTGCTATGCTGCTGTAA
GTAGAAAGCATGAAGCTTTTTGATCATGTAGGGCTTATTGTAGAGGGTATCAATTGGCCTAACTAAGCAGGATTGAATTTACCAGAGGCT
AAGTTCAGATAGTAAGAATAATGCATATGTGATTGTTCTTAAAGTCAATGTATTAAATAAGGTATTTTTCCTTTTCCCTCTTACTGGATT
TTTCAATTTTCAAACCATATGGCCTAGGTAACTTTAATTGAAATAATATAGATTTAGTTGAATACTATTCAGGAAGTAATAAATTTTAAT
ATATCACATTGAAATTATGCAGTGGTGATGAATTTTGGTGTTTCCCCCCTCTTTCTGGTTTTACATCATGAGGATCAGTTAGCTGCTGAC
AAGAAAAGTCATCTTGTGTCTTTTGTAAATTGAATTTTTTTTTTAAATCTATTAGGAACTGGAAAACAGCAAGTATGGTTGATTCTCATT
ATTCAAGGTAGTTACGTTCTATAAAGTCACTGCGAACACTGAATTAGCAAATATAGAACCTAGGGGAAATACAAGGCTAGATTTCTGCAA
GCCACTGGTCACATTTTCATCAAGCAGTCAACATGTAAATTTCTGTTGTAAAGACACCTTATTTAATATAATCGATTCATTAACATTGAA
GTCATGACCAACAACACTGTAACTCATGCCTGAATGAAGCTTATCTGACACATAAGCTTCATAAGGCACACAACAGCCTTTTTACCCTTA
GGAACAGCTTTTTGCCCTTAGCACTATGCTTGGGGGCCATTTTAAACAGTGAAATCAAAAAAAGAACAGAAATGCAAAAACCATGGCATT
AGCGTAAAAAGGACACGTTTATAGTATGAAAGCTGGAACATGGCCTTGTTCAACCTCAGCTCAGAATATGTGTACAGCAAGTTTTTTGCT
GTACCACAAAATTTTAGGTTAGGCAAATTCACAAATACGGAATCCATGAATAACGAGGATCAACTGTACTTAACTATATTTTAAAGCTGT
GACATTTATCTACCTGGTTTATGGAATAGAATTTATTGCTGAATCATGCTCCAGTATTTGAGTGATGTTTTAAATATCCTATGTCTGAAA
ATAATTCCTCCTAATTGTGTGGTAATTTGCTTTTACTGTTTCCACAGTATTTCAGGTCTTTGCTCATTCACTCAGTAATACTGAGCACTT
ACCATGTACCAGAATTTTACTAGGCACAACCATGAATAAAAATACAATTCTCTTGCACCATTAAATAGTGTGTTAAGTGCTACGGCAGCA
AATTGCTACATGTGCTGGATATCTCTTGTTTTCCCCTCCAGCTCCACTCTGCTCTTGCCCACAAAGCTGACCCGAATGGACCACAGCAGT
GGGCTCCTATGCCTCCTGGCTTCTGAGTGGGTTTGGCCAAGGAGTGTCCTGGCCAGAGATCAGAGGATGGTAGGGTGCCTATTCTCGGCT
CTTCTCCTGGGGTTGGGGGGCTGCCTTAGCAGCCAAAGGTCACTTCTCCCAAACTCCTTCCCTGCTTTCCAGGTTGCCAGTCCCTGCACT
CTTCCTTTCTGGCCAAGGATGATGTCAGTTCTGCTGCTACTAGCCTGGAGTTGCAGAAGCTACTGTGCTTCCTCTTTGGGTAGCCTATAC
CTATACTTATCTCCTCATAATATCTTCATGTAAAGAACCATCTGTTTCTTATTGGAATCAAGACCAATACCAAGGAGAAATTCCTAGGGA
ACAAAAATTCCAATGAGGAATTGACCTCTTTGTCAGATCCTTATCACCAAACATTAGAAAAGATCTCATAACTTTATACAGCATGTTGTA
AGCATTTTGATAACTAAAATCCTGTTCTAGTGAATGTCATGCAGATAACTACACAAGGAGATTAATTTAAATTTGCCTTCTTTGGCAAGC
CCTTAAACCAATGGCTAAAGCAGTTAGTTGTGAGTTTCTGAGTAGGTCCCAATGCGTTTATTTCATTTGTCCAACCTAGCACAGAGATCC
TTTGATACTTTAATTGCATGGCTTTTCCAATCAGACGAAATTTCAGTCTGAGAGAGGACATATTTTCTGAGGTTTATAGTTTTAGGATTG
TCCAAAAGGCCTATGATCTCTTCTTAGCATGACAGAAAGAGGGAAAGATAAGTTAAATTTCAAGGGGGTCATATCATCACACTTTGGTCT
TATTTCATTTTCAATGATTTCCTAGATCACTTTAACTTTTTTGTGTCATGGACTCCTCAGAATAATGGGTTTTTTTTGTTTGTTTGTTTG
TTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGAAATCTCAGCTCACTGCAACCTCCGCCTCCTGAGGTTCAAGTG
ATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACATGCCACCACACCCAGCTAATTTTTGTATTTTTTAGTAGAGACAGGG
TTTCACCGTGTTGGCGAGACTGATCTTGAACTCCTGACATCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATG
AGCCACCATGCCTGGCCAGAATAATGTTTTTAAATGCAGAAAAGGAAATGCATGGGGTTACAAGGGAAACGAATTACACTGAAGTGTAAG
CTACCAAATAATTTATGATGTGGTAGTTATAGGTGTGCATTTAATAGCCAGATCTACGAGTGGATGTAATAACTGCTATGATGTTGAAGT
AGCATAAAACATATATTAGATATCTGCAACAACTGTGATGTAACATGAAAATACCTGATTTCTGTTGACAAAGTTACTGCTAGTACAACT
GTGGATTGTTGTCTGCACTCGTCATTGAAGGAAATACTAAATTTTAGTTTTAGGCTAGTGAAATTAAAGTTAATTTTTCCCATCCAAGTT
CATGTATCTTCTGAATTCTATCCGTGAATCCCTTAGAGGTCTGTGAATTGTAGGTTAAGAACCCCTGCCCTAGCTAATCAGATCCACCAA
TGTTTCAAATAGGACTATAACTTATTCAAAGGCCAATGATACTTCGCATAATTCAATTTTAATATTATTCACATTTCATGTCACAAATTT

>49581_49581_3_LPP-SEC62_LPP_chr3_188327632_ENST00000448637_SEC62_chr3_169693396_ENST00000337002_length(amino acids)=776AA_BP=389
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHK
RMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYN
TQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNP
PGMYPVTGPKKTYITDPVSAPCAPPLQPKEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFT
TRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKEKKKDGEKEESKKEETPGTPKKKE
TKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCILFLIIW
LITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDT

--------------------------------------------------------------
>49581_49581_4_LPP-SEC62_LPP_chr3_188327632_ENST00000448637_SEC62_chr3_169693396_ENST00000480708_length(transcript)=2638nt_BP=1259nt
ATTTCTCTTCCGAGAGCTTCAGTTTCCTCACGTGCCAAGCGGACGGGTTGGAAGTTGGTCTTTGCCAGCTCTGACACCTTCATTGCAGTT
GGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAGATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCA
CTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCATTCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCAC
CCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCATACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCAC
CTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAACTTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTAC
AGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTGGACGCTGAGATTGACTCCTTGACCAGCATCTTGGCTGACCTTG
AGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGTTCAACAGCCTCTCCTCCAGTTTCGACCCCAGTCACAGGACACA
AGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAGTCTACATTGAAACCACAGCCTGCACCCCAGGCTGGACCCATCC
CTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCAGCCTCCTACACCACGGCCTCCACTTCTTCAAGGCCTACCTTTA
ATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCCCCTTCATCAGGACAAATTTATGGCTCAGGGCCCCAGGGCTATA
ACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACACGGGGAGGCATGGATTATGCCTACATTCCACCACCAGGACTTC
AGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTATGAAGGCTACTATGCAGCAGGGCCAGGCTATGGGGGCAGAAATG
ACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAACGGGAACCAGGGTACACTCCTCCTGGAGCAGGGAACCAGAACC
CTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACAGATCCTGTTTCAGCCCCCTGTGCGCCACCATTGCAGCCAAAGG
AAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTTCGATTCAACTGTCCAACAAAGTCCACCAATATGATGGGTCACC
GGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGATTCAAAGTGGGCAAAGGCCAAGAAAGGAGAGGAAGCTTTATTTA
CAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAGCAGTTTTTTCACCGAGCCCTAAAAGTAATGAAAATGAAATATG
ATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGAAAAGAAGAAGATAAAAAGAGCAAGAAAGAAAATATAAAGGATG
AGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAAGAATCCAAAAAGGAGGAAACTCCAGGAACTCCTAAAAAGAAGG
AAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTTCTGGATGGAAATGAGGTGTATGTATGGATCTATGACCCAGTTC
ACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATAGCGGCCACCCTCTTCCCCCTTTGGCCAGCAGAAATGAGAGTAG
GTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATTCTTCTCCTTGCTGTTGCTCGATGCATTCTATTTCTCATCATTT
GGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTGACTGCTGATGTGGGCTTCATTGACTCCTTCAGGCCTCTGTACA
CACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAGTCTGAAACCAAAAAGCAACAGAAGTCCGACAGTGAGGAAAAGT
CAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGAAATCATGGAACAGAAGGCTCGGGGGGAGAACGGCATTCAGACA
CGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAAATGATTTTGAAATGATAACAAAAGAGGAACTGGAAC
AGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGATGGAGAAACACCTAAATCTTCACATGAAAAATCATAATCTGACT
AATTTTGGGACTGAATGAATAAGTACAAGAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGTCTCCAGCAGAGAA
AGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAGTGTATTCTGTACATAATTTA

>49581_49581_4_LPP-SEC62_LPP_chr3_188327632_ENST00000448637_SEC62_chr3_169693396_ENST00000480708_length(amino acids)=776AA_BP=389
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHK
RMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYN
TQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNP
PGMYPVTGPKKTYITDPVSAPCAPPLQPKEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFT
TRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKEKKKDGEKEESKKEETPGTPKKKE
TKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCILFLIIW
LITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDT

--------------------------------------------------------------
>49581_49581_5_LPP-SEC62_LPP_chr3_188327632_ENST00000543006_SEC62_chr3_169693396_ENST00000337002_length(transcript)=7776nt_BP=1302nt
GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC
GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG
ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT
TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA
TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC
TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTG
GACGCTGAGATTGACTCCTTGACCAGCATCTTGGCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGT
TCAACAGCCTCTCCTCCAGTTTCGACCCCAGTCACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAG
TCTACATTGAAACCACAGCCTGCACCCCAGGCTGGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCA
GCCTCCTACACCACGGCCTCCACTTCTTCAAGGCCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCC
CCTTCATCAGGACAAATTTATGGCTCAGGGCCCCAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACA
CGGGGAGGCATGGATTATGCCTACATTCCACCACCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTAT
GAAGGCTACTATGCAGCAGGGCCAGGCTATGGGGGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAA
CGGGAACCAGGGTACACTCCTCCTGGAGCAGGGAACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACA
GATCCTGTTTCAGCCCCCTGTGCGCCACCATTGCAGCCAAAGGAAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTT
CGATTCAACTGTCCAACAAAGTCCACCAATATGATGGGTCACCGGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGAT
TCAAAGTGGGCAAAGGCCAAGAAAGGAGAGGAAGCTTTATTTACAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAG
CAGTTTTTTCACCGAGCCCTAAAAGTAATGAAAATGAAATATGATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGA
AAAGAAGAAGATAAAAAGAGCAAGAAAGAAAATATAAAGGATGAGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAA
GAATCCAAAAAGGAGGAAACTCCAGGAACTCCTAAAAAGAAGGAAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTT
CTGGATGGAAATGAGGTGTATGTATGGATCTATGACCCAGTTCACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATA
GCGGCCACCCTCTTCCCCCTTTGGCCAGCAGAAATGAGAGTAGGTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATT
CTTCTCCTTGCTGTTGCTCGATGCATTCTATTTCTCATCATTTGGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTG
ACTGCTGATGTGGGCTTCATTGACTCCTTCAGGCCTCTGTACACACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAG
TCTGAAACCAAAAAGCAACAGAAGTCCGACAGTGAGGAAAAGTCAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGA
AATCATGGAACAGAAGGCTCGGGGGGAGAACGGCATTCAGACACGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGA
AATGGAAATGATTTTGAAATGATAACAAAAGAGGAACTGGAACAGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGAT
GGAGAAACACCTAAATCTTCACATGAAAAATCATAATCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGTTGGATTTTCTATGT
TGGCTGATTACCATATTGAACACATGGCATTTGTAGCATTCTTTAAATCTATCTACTGAAATGTATTTGACATTCAAGCAGTTATATTCG
GTCCTTCATTTTATAGAATATTGGCACTATTATTGGTACAGTTTAAAGCCATTAATATGTTTTATCCATTTGATAATTTTACAGTAAGTA
GGTCTCATTCATTTTGACAGTTATCAAAGATGTACTTTCCACAGTTAAATTTACATTAATGGCAATTTTTGATAGTTTTATGGCTTTTTA
CTGTTAGACTAATCAAAAATAACTTTAAAAGGAACAAAGAAACTCCAACATTTCACATTATGCATAGTTATGTAGCCATTTCACAGTTTC
TTTAAGATGTGTAAACTCATTGTCCTTGATAGTTTTTATTTTTCATTATAAAATTATACCAGGAGATTTCTTTTAAGATTCTGAGTTAGC
AGAGTTCAAAACTATTTTGTGGAAACAAGCCAACTAGTAACAATGCAGCAACACTTCTGGTTTAGCTAAATTATTTTTCCAATGTAGGAA
ATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGTCTCCAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTC
CCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAGTGTATTCTGTACATAATTTACAAATAAAACATTTTATTTTAATTGTTACTTATT
ATTTAGATATTTCTCAACACTTAAATTCATAAAATTAAGACCATGTAAGGGTATGTTTTTAGAGAAATGGAAGTTTGAGTAACCCACAGA
ACATCTGTGATCTTTCTACAGCAGCTTCAGTTTTGTGCCAACATTCCATGTATTTTGAATATGAGCAAAAACTGATCTTAAGAGCAGACT
TAAAGTAGCTTTGTACGCCTTAATGTTCATTTTGATTTATTTTAAATCTTTACATTCAGAAATGAGATACTGTATTATCAGACCAGGAGG
CATTGCTGTGAAAGATAATTTCCTATTCTAAAATATCAAATTTAAAATAAAGATAATGAAAGAAAACATAAGAGAACTATTGGACTCTAA
TTGCTTTGAACTAGTTTTGCAGTTTGACTTTACGTCTTATACATCTTAGTTACAAGTCTTTGGAAACTCTTGTTTACTTATGAGCATAAT
CATTCCTTGGAGTTATACTAACTAATAATGAATATTAAATGATTTTTCTTCAGTCACAGTGAGAGCATCTTGCTTTGTGGTTGAAATAGG
TAGTGTATGTCAGTCTTTGCTTTAGGCTGTTTCTCATCTAAGTGTTTGAATTAAAGATGTTAAATTTTTCTAATTGTGAAAAATATGTTT
TCTGTATCGACACATTTTATTAAACTTGGCTTGATTGCTTCTTTATAGTAGTCCCTGTAAGTGGACATAAATGTGGCTATTTGATGTTAA
TGCAACTATGTCAAGGCTGCAATCACTTTAATAGTTTCTTTTTAGCAAATAAATGTTCATTGATGAAGTGCCTGGGTATTTTCCCGTCCC
ATTTGCAGAGCTCTACTACTTCATTTCCACAGTAAGCATATATATAATGATCACTTCTGAGTTTATCACCAGTAACATTGATACCTATTT
TGGGGTATAAACATGGTGTTTTTCAGAAATAAAAATTATTTCATTAACCTTTACTATTACTGTGATAATACCCAGGCACTCAATATTCAT
CCTGAAATTTTTTATAATATATGTAATTTGTCTAGTCTTAAAGACATTTGGAGCATGGCCAACAGGAAGGTCAGCTTCTTACTGATGTGT
GTGGATTCTTACAGAATGTTAGTACAAATTTTTATAAATATTTGGTGATCCCTGGGGGGAAATATCATTCTTACTATGGTTAGAAAGTGA
ATTAGAAATTTCAGCTCAGTTTCTATTTTACTATTCAAGTTGTGTACTTTAAACAAATATAAAAATCAAAAGGCTGCCTCTATTACAATC
CTCAGTGGAATAGATGGCTATCTTTCTTGGCTAACATTAAATATTCTTGTACCAGAGCATGGAAAATCGTTTATAATTGTTAATAGAATG
GCGATTTTTTTTTAAGAACTTCAGATTTGCTATGCTGCTGTAAGTAGAAAGCATGAAGCTTTTTGATCATGTAGGGCTTATTGTAGAGGG
TATCAATTGGCCTAACTAAGCAGGATTGAATTTACCAGAGGCTAAGTTCAGATAGTAAGAATAATGCATATGTGATTGTTCTTAAAGTCA
ATGTATTAAATAAGGTATTTTTCCTTTTCCCTCTTACTGGATTTTTCAATTTTCAAACCATATGGCCTAGGTAACTTTAATTGAAATAAT
ATAGATTTAGTTGAATACTATTCAGGAAGTAATAAATTTTAATATATCACATTGAAATTATGCAGTGGTGATGAATTTTGGTGTTTCCCC
CCTCTTTCTGGTTTTACATCATGAGGATCAGTTAGCTGCTGACAAGAAAAGTCATCTTGTGTCTTTTGTAAATTGAATTTTTTTTTTAAA
TCTATTAGGAACTGGAAAACAGCAAGTATGGTTGATTCTCATTATTCAAGGTAGTTACGTTCTATAAAGTCACTGCGAACACTGAATTAG
CAAATATAGAACCTAGGGGAAATACAAGGCTAGATTTCTGCAAGCCACTGGTCACATTTTCATCAAGCAGTCAACATGTAAATTTCTGTT
GTAAAGACACCTTATTTAATATAATCGATTCATTAACATTGAAGTCATGACCAACAACACTGTAACTCATGCCTGAATGAAGCTTATCTG
ACACATAAGCTTCATAAGGCACACAACAGCCTTTTTACCCTTAGGAACAGCTTTTTGCCCTTAGCACTATGCTTGGGGGCCATTTTAAAC
AGTGAAATCAAAAAAAGAACAGAAATGCAAAAACCATGGCATTAGCGTAAAAAGGACACGTTTATAGTATGAAAGCTGGAACATGGCCTT
GTTCAACCTCAGCTCAGAATATGTGTACAGCAAGTTTTTTGCTGTACCACAAAATTTTAGGTTAGGCAAATTCACAAATACGGAATCCAT
GAATAACGAGGATCAACTGTACTTAACTATATTTTAAAGCTGTGACATTTATCTACCTGGTTTATGGAATAGAATTTATTGCTGAATCAT
GCTCCAGTATTTGAGTGATGTTTTAAATATCCTATGTCTGAAAATAATTCCTCCTAATTGTGTGGTAATTTGCTTTTACTGTTTCCACAG
TATTTCAGGTCTTTGCTCATTCACTCAGTAATACTGAGCACTTACCATGTACCAGAATTTTACTAGGCACAACCATGAATAAAAATACAA
TTCTCTTGCACCATTAAATAGTGTGTTAAGTGCTACGGCAGCAAATTGCTACATGTGCTGGATATCTCTTGTTTTCCCCTCCAGCTCCAC
TCTGCTCTTGCCCACAAAGCTGACCCGAATGGACCACAGCAGTGGGCTCCTATGCCTCCTGGCTTCTGAGTGGGTTTGGCCAAGGAGTGT
CCTGGCCAGAGATCAGAGGATGGTAGGGTGCCTATTCTCGGCTCTTCTCCTGGGGTTGGGGGGCTGCCTTAGCAGCCAAAGGTCACTTCT
CCCAAACTCCTTCCCTGCTTTCCAGGTTGCCAGTCCCTGCACTCTTCCTTTCTGGCCAAGGATGATGTCAGTTCTGCTGCTACTAGCCTG
GAGTTGCAGAAGCTACTGTGCTTCCTCTTTGGGTAGCCTATACCTATACTTATCTCCTCATAATATCTTCATGTAAAGAACCATCTGTTT
CTTATTGGAATCAAGACCAATACCAAGGAGAAATTCCTAGGGAACAAAAATTCCAATGAGGAATTGACCTCTTTGTCAGATCCTTATCAC
CAAACATTAGAAAAGATCTCATAACTTTATACAGCATGTTGTAAGCATTTTGATAACTAAAATCCTGTTCTAGTGAATGTCATGCAGATA
ACTACACAAGGAGATTAATTTAAATTTGCCTTCTTTGGCAAGCCCTTAAACCAATGGCTAAAGCAGTTAGTTGTGAGTTTCTGAGTAGGT
CCCAATGCGTTTATTTCATTTGTCCAACCTAGCACAGAGATCCTTTGATACTTTAATTGCATGGCTTTTCCAATCAGACGAAATTTCAGT
CTGAGAGAGGACATATTTTCTGAGGTTTATAGTTTTAGGATTGTCCAAAAGGCCTATGATCTCTTCTTAGCATGACAGAAAGAGGGAAAG
ATAAGTTAAATTTCAAGGGGGTCATATCATCACACTTTGGTCTTATTTCATTTTCAATGATTTCCTAGATCACTTTAACTTTTTTGTGTC
ATGGACTCCTCAGAATAATGGGTTTTTTTTGTTTGTTTGTTTGTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCG
AAATCTCAGCTCACTGCAACCTCCGCCTCCTGAGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACATGC
CACCACACCCAGCTAATTTTTGTATTTTTTAGTAGAGACAGGGTTTCACCGTGTTGGCGAGACTGATCTTGAACTCCTGACATCAGGTGA
TCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCTGGCCAGAATAATGTTTTTAAATGCAGAAAAGGAA
ATGCATGGGGTTACAAGGGAAACGAATTACACTGAAGTGTAAGCTACCAAATAATTTATGATGTGGTAGTTATAGGTGTGCATTTAATAG
CCAGATCTACGAGTGGATGTAATAACTGCTATGATGTTGAAGTAGCATAAAACATATATTAGATATCTGCAACAACTGTGATGTAACATG
AAAATACCTGATTTCTGTTGACAAAGTTACTGCTAGTACAACTGTGGATTGTTGTCTGCACTCGTCATTGAAGGAAATACTAAATTTTAG
TTTTAGGCTAGTGAAATTAAAGTTAATTTTTCCCATCCAAGTTCATGTATCTTCTGAATTCTATCCGTGAATCCCTTAGAGGTCTGTGAA
TTGTAGGTTAAGAACCCCTGCCCTAGCTAATCAGATCCACCAATGTTTCAAATAGGACTATAACTTATTCAAAGGCCAATGATACTTCGC
ATAATTCAATTTTAATATTATTCACATTTCATGTCACAAATTTAGTAAGTTACATGTGTTATGTGATGTTTTGTTTTGATAGATTATATC

>49581_49581_5_LPP-SEC62_LPP_chr3_188327632_ENST00000543006_SEC62_chr3_169693396_ENST00000337002_length(amino acids)=818AA_BP=431
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASY
TTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKEVGEPSKEEKAVAKYLRFN
CPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEE
DKKSKKENIKDEKTKKEKEKKKDGEKEESKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAAT
LFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSET
KKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCEEDEEEENDGET

--------------------------------------------------------------
>49581_49581_6_LPP-SEC62_LPP_chr3_188327632_ENST00000543006_SEC62_chr3_169693396_ENST00000480708_length(transcript)=2681nt_BP=1302nt
GTGGGAACTTTGAGGCTCAGAGACAGAGCAGAAGACAGAACCTGGTCTTCTGATTCCCTGTGTTCTGCTTTTTTCATTGTTCCACTGGAC
GCTCATCAGAGGGAAGATCTTTTTCCTCAATTGCATTGCAGTTGGCTGAACCTTGTGTCAACCATCCATTCCAGGAGCCAGCTATCTGAG
ATTCCAACAATGTCTCACCCATCTTGGCTGCCACCCAAAAGCACTGGTGAGCCCCTCGGCCATGTGCCTGCACGGATGGAGACCACCCAT
TCCTTTGGGAACCCCAGCATTTCAGTGTCTACACAACAGCCACCCAAAAAGTTTGCCCCGGTAGTTGCTCCAAAACCTAAGTACAACCCA
TACAAACAACCTGGAGGTGAGGGTGATTTTCTTCCACCCCCACCTCCACCTCTAGATGATTCCAGTGCCCTTCCATCTATCTCTGGAAAC
TTTCCTCCTCCACCACCTCTTGATGAAGAGGCTTTCAAAGTACAGGGGAATCCCGGAGGCAAGACACTTGAGGAGAGGCGCTCCAGCCTG
GACGCTGAGATTGACTCCTTGACCAGCATCTTGGCTGACCTTGAGTGCAGCTCCCCCTATAAGCCTCGGCCTCCACAGAGCTCCACTGGT
TCAACAGCCTCTCCTCCAGTTTCGACCCCAGTCACAGGACACAAGAGAATGGTCATCCCGAACCAACCCCCTCTAACAGCAACCAAGAAG
TCTACATTGAAACCACAGCCTGCACCCCAGGCTGGACCCATCCCTGTGGCTCCAATCGGAACACTCAAACCCCAGCCTCAGCCAGTCCCA
GCCTCCTACACCACGGCCTCCACTTCTTCAAGGCCTACCTTTAATGTGCAGGTGAAGTCAGCCCAGCCCAGCCCTCATTATATGGCTGCC
CCTTCATCAGGACAAATTTATGGCTCAGGGCCCCAGGGCTATAACACTCAGCCAGTTCCTGTCTCTGGGCAGTGTCCACCTCCTTCAACA
CGGGGAGGCATGGATTATGCCTACATTCCACCACCAGGACTTCAGCCGGAGCCTGGGTATGGGTATGCCCCCAACCAGGGACGCTATTAT
GAAGGCTACTATGCAGCAGGGCCAGGCTATGGGGGCAGAAATGACTCTGACCCTACCTATGGTCAACAAGGTCACCCAAATACCTGGAAA
CGGGAACCAGGGTACACTCCTCCTGGAGCAGGGAACCAGAACCCTCCTGGGATGTATCCAGTCACTGGTCCCAAGAAGACCTATATCACA
GATCCTGTTTCAGCCCCCTGTGCGCCACCATTGCAGCCAAAGGAAGTTGGTGAACCATCTAAAGAAGAGAAGGCTGTGGCCAAGTATCTT
CGATTCAACTGTCCAACAAAGTCCACCAATATGATGGGTCACCGGGTTGATTATTTTATTGCTTCAAAAGCAGTGGACTGTCTTTTGGAT
TCAAAGTGGGCAAAGGCCAAGAAAGGAGAGGAAGCTTTATTTACAACCAGGGAGTCTGTGGTTGACTACTGCAACAGGCTTTTAAAGAAG
CAGTTTTTTCACCGAGCCCTAAAAGTAATGAAAATGAAATATGATAAAGACATAAAGAAAGAAAAAGATAAAGGAAAAGCTGAAAGTGGA
AAAGAAGAAGATAAAAAGAGCAAGAAAGAAAATATAAAGGATGAGAAGACAAAAAAAGAAAAAGAGAAAAAAAAAGATGGTGAAAAGGAA
GAATCCAAAAAGGAGGAAACTCCAGGAACTCCTAAAAAGAAGGAAACTAAGAAAAAATTCAAACTTGAGCCACATGATGATCAGGTTTTT
CTGGATGGAAATGAGGTGTATGTATGGATCTATGACCCAGTTCACTTTAAAACATTTGTCATGGGATTAATTCTTGTGATTGCAGTAATA
GCGGCCACCCTCTTCCCCCTTTGGCCAGCAGAAATGAGAGTAGGTGTTTATTACCTCAGTGTGGGTGCAGGCTGTTTTGTAGCCAGTATT
CTTCTCCTTGCTGTTGCTCGATGCATTCTATTTCTCATCATTTGGCTCATAACTGGAGGAAGGCACCACTTTTGGTTCTTGCCAAATCTG
ACTGCTGATGTGGGCTTCATTGACTCCTTCAGGCCTCTGTACACACATGAATACAAAGGACCAAAAGCAGACTTAAAGAAAGATGAGAAG
TCTGAAACCAAAAAGCAACAGAAGTCCGACAGTGAGGAAAAGTCAGACAGTGAGAAAAAGGAAGATGAGGAGGGGAAAGTAGGACCAGGA
AATCATGGAACAGAAGGCTCGGGGGGAGAACGGCATTCAGACACGGACAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGA
AATGGAAATGATTTTGAAATGATAACAAAAGAGGAACTGGAACAGCAAACAGATGGGGATTGTGAAGAGGATGAGGAAGAGGAAAATGAT
GGAGAAACACCTAAATCTTCACATGAAAAATCATAATCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGAAATCCACACTGATT
TGTACGTCTGACTGAGAGAAAGATGGTCGTCTCCAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCC

>49581_49581_6_LPP-SEC62_LPP_chr3_188327632_ENST00000543006_SEC62_chr3_169693396_ENST00000480708_length(amino acids)=818AA_BP=431
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASY
TTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKEVGEPSKEEKAVAKYLRFN
CPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEE
DKKSKKENIKDEKTKKEKEKKKDGEKEESKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAAT
LFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSET
KKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCEEDEEEENDGET

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LPP-SEC62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LPP-SEC62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LPP-SEC62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource