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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LPP-ZNRF1 (FusionGDB2 ID:49590)

Fusion Gene Summary for LPP-ZNRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: LPP-ZNRF1
Fusion gene ID: 49590
HgeneTgene
Gene symbol

LPP

ZNRF1

Gene ID

4026

84937

Gene nameLIM domain containing preferred translocation partner in lipomazinc and ring finger 1
Synonyms-NIN283
Cytomap

3q27.3-q28

16q23.1

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnerE3 ubiquitin-protein ligase ZNRF1RING-type E3 ubiquitin transferase ZNRF1nerve injury gene 283nerve injury-induced gene 283 proteinzinc and ring finger 1, E3 ubiquitin protein ligasezinc and ring finger protein 1zinc/RING finger protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312675, ENST00000448637, 
ENST00000543006, ENST00000471917, 
ENST00000320619, ENST00000335325, 
ENST00000566250, ENST00000567962, 
ENST00000564320, 
Fusion gene scores* DoF score41 X 30 X 15=184507 X 7 X 6=294
# samples 529
** MAII scorelog2(52/18450*10)=-5.14896538280667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LPP [Title/Abstract] AND ZNRF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLPP(187943315)-ZNRF1(75127470), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZNRF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N5-A4RF-01ALPPchr3

187943315

-ZNRF1chr16

75127470

+
ChimerDB4UCSTCGA-N5-A4RF-01ALPPchr3

187943315

+ZNRF1chr16

75127470

+
ChimerDB4UCSTCGA-N5-A4RFLPPchr3

187871151

+ZNRF1chr16

75127470

+
ChimerDB4UCSTCGA-N5-A4RFLPPchr3

187871809

+ZNRF1chr16

75127470

+
ChimerDB4UCSTCGA-N5-A4RFLPPchr3

187926106

+ZNRF1chr16

75127470

+
ChimerDB4UCSTCGA-N5-A4RFLPPchr3

187943315

+ZNRF1chr16

75118327

+
ChimerDB4UCSTCGA-N5-A4RFLPPchr3

187943315

+ZNRF1chr16

75127469

+
ChimerDB4UCSTCGA-N5-A4RFLPPchr3

187943315

+ZNRF1chr16

75127470

+


Top

Fusion Gene ORF analysis for LPP-ZNRF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000312675ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3CDSENST00000312675ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3CDSENST00000312675ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3CDSENST00000312675ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000312675ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3CDSENST00000448637ENST00000320619LPPchr3

187871151

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000448637ENST00000335325LPPchr3

187871151

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000448637ENST00000566250LPPchr3

187871151

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000448637ENST00000567962LPPchr3

187871151

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3CDSENST00000543006ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3CDSENST00000543006ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3CDSENST00000543006ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3CDSENST00000543006ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3UTRENST00000312675ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3UTRENST00000312675ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-3UTRENST00000448637ENST00000564320LPPchr3

187871151

+ZNRF1chr16

75127470

+
5UTR-3UTRENST00000543006ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+
5UTR-3UTRENST00000543006ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127469

+
5UTR-intronENST00000312675ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000312675ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000312675ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000312675ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000312675ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000543006ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000543006ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000543006ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000543006ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75118327

+
5UTR-intronENST00000543006ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-3CDSENST00000312675ENST00000320619LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000320619LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000320619LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000335325LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000335325LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000335325LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000566250LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000566250LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000566250LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000567962LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000567962LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000312675ENST00000567962LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000320619LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000320619LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000448637ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000335325LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000335325LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000448637ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000566250LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000566250LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000448637ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000567962LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000567962LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000448637ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000471917ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000320619LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000320619LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000320619LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000471917ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000335325LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000335325LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000335325LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000471917ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000566250LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000566250LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000566250LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000471917ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000567962LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000567962LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000567962LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000471917ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3CDSENST00000543006ENST00000320619LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000320619LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000320619LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000335325LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000335325LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000335325LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000566250LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000566250LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000566250LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000567962LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000567962LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3CDSENST00000543006ENST00000567962LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3UTRENST00000312675ENST00000564320LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3UTRENST00000312675ENST00000564320LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3UTRENST00000312675ENST00000564320LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3UTRENST00000448637ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3UTRENST00000448637ENST00000564320LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3UTRENST00000448637ENST00000564320LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3UTRENST00000448637ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3UTRENST00000471917ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127470

+
intron-3UTRENST00000471917ENST00000564320LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3UTRENST00000471917ENST00000564320LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3UTRENST00000471917ENST00000564320LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-3UTRENST00000471917ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75127469

+
intron-3UTRENST00000543006ENST00000564320LPPchr3

187871151

+ZNRF1chr16

75127470

+
intron-3UTRENST00000543006ENST00000564320LPPchr3

187871809

+ZNRF1chr16

75127470

+
intron-3UTRENST00000543006ENST00000564320LPPchr3

187926106

+ZNRF1chr16

75127470

+
intron-intronENST00000448637ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000448637ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000448637ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000448637ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000448637ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000471917ENST00000320619LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000471917ENST00000335325LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000471917ENST00000564320LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000471917ENST00000566250LPPchr3

187943315

+ZNRF1chr16

75118327

+
intron-intronENST00000471917ENST00000567962LPPchr3

187943315

+ZNRF1chr16

75118327

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LPP-ZNRF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LPPchr3187871151+ZNRF1chr1675127469+0.0124870070.987513
LPPchr3187943315+ZNRF1chr1675127469+2.23E-081
LPPchr3187943315+ZNRF1chr1675127469+2.23E-081
LPPchr3187871151+ZNRF1chr1675127469+0.0124870070.987513
LPPchr3187943315+ZNRF1chr1675127469+2.23E-081
LPPchr3187943315+ZNRF1chr1675127469+2.23E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LPP-ZNRF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:187943315/:75127470)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LPP-ZNRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LPP-ZNRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LPP-ZNRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LPP-ZNRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource