FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LRBA-GTF2E2 (FusionGDB2 ID:49612)

Fusion Gene Summary for LRBA-GTF2E2

check button Fusion gene summary
Fusion gene informationFusion gene name: LRBA-GTF2E2
Fusion gene ID: 49612
HgeneTgene
Gene symbol

LRBA

GTF2E2

Gene ID

987

2961

Gene nameLPS responsive beige-like anchor proteingeneral transcription factor IIE subunit 2
SynonymsBGL|CDC4L|CVID8|LAB300|LBAFE|TF2E2|TFIIE-B|TTD6
Cytomap

4q31.3

8p12

Type of geneprotein-codingprotein-coding
Descriptionlipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containingtranscription initiation factor IIE subunit betaTFIIE beta subunitTFIIE-betageneral transcription factor IIE, polypeptide 2, beta 34kDa
Modification date2020032020200313
UniProtAcc

P50851

P29084

Ensembl transtripts involved in fusion geneENST00000357115, ENST00000507224, 
ENST00000510413, ENST00000535741, 
ENST00000503716, 		ENST00000522833, 
ENST00000355904, 
Fusion gene scores* DoF score31 X 32 X 15=1488010 X 6 X 6=360
# samples 4111
** MAII scorelog2(41/14880*10)=-5.18160680648995
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRBA [Title/Abstract] AND GTF2E2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRBA(151336589)-GTF2E2(30437913), # samples:1
Anticipated loss of major functional domain due to fusion event.LRBA-GTF2E2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGTF2E2

GO:0006366

transcription by RNA polymerase II

27193682


check buttonFusion gene breakpoints across LRBA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GTF2E2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A6IBLRBAchr4

151336589

-GTF2E2chr8

30437913

-


Top

Fusion Gene ORF analysis for LRBA-GTF2E2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357115ENST00000522833LRBAchr4

151336589

-GTF2E2chr8

30437913

-
5CDS-intronENST00000507224ENST00000522833LRBAchr4

151336589

-GTF2E2chr8

30437913

-
5CDS-intronENST00000510413ENST00000522833LRBAchr4

151336589

-GTF2E2chr8

30437913

-
5CDS-intronENST00000535741ENST00000522833LRBAchr4

151336589

-GTF2E2chr8

30437913

-
5UTR-3CDSENST00000503716ENST00000355904LRBAchr4

151336589

-GTF2E2chr8

30437913

-
5UTR-intronENST00000503716ENST00000522833LRBAchr4

151336589

-GTF2E2chr8

30437913

-
Frame-shiftENST00000507224ENST00000355904LRBAchr4

151336589

-GTF2E2chr8

30437913

-
Frame-shiftENST00000510413ENST00000355904LRBAchr4

151336589

-GTF2E2chr8

30437913

-
In-frameENST00000357115ENST00000355904LRBAchr4

151336589

-GTF2E2chr8

30437913

-
In-frameENST00000535741ENST00000355904LRBAchr4

151336589

-GTF2E2chr8

30437913

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535741LRBAchr4151336589-ENST00000355904GTF2E2chr830437913-8504766847477002408
ENST00000357115LRBAchr4151336589-ENST00000355904GTF2E2chr830437913-8307747124475032419

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535741ENST00000355904LRBAchr4151336589-GTF2E2chr830437913-0.0023423350.99765766
ENST00000357115ENST00000355904LRBAchr4151336589-GTF2E2chr830437913-0.0008858620.9991141

Top

Fusion Genomic Features for LRBA-GTF2E2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LRBA-GTF2E2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:151336589/chr8:30437913)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRBA

P50851

GTF2E2

P29084

FUNCTION: May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. {ECO:0000250}.FUNCTION: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:1956404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48581006_105324092864.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47571006_105323982852.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48581990_199424092864.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47571990_199423982852.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48582073_218124092864.0DomainBEACH-type PH
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47572073_218123982852.0DomainBEACH-type PH
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48581301_134324092864.0RepeatNote=WD 1
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47571301_134323982852.0RepeatNote=WD 1
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48581531_154824092864.0TransmembraneHelical
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47571531_154823982852.0TransmembraneHelical
TgeneGTF2E2chr4:151336589chr8:30437913ENST0000035590458251_271214292.0Compositional biasNote=Arg/Lys-rich (basic)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48582200_248924092864.0DomainBEACH
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47572200_248923982852.0DomainBEACH
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48582591_263324092864.0RepeatNote=WD 2
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48582636_267924092864.0RepeatNote=WD 3
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48582695_273524092864.0RepeatNote=WD 4
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48582777_281624092864.0RepeatNote=WD 5
HgeneLRBAchr4:151336589chr8:30437913ENST00000357115-48582819_285824092864.0RepeatNote=WD 6
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47572591_263323982852.0RepeatNote=WD 2
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47572636_267923982852.0RepeatNote=WD 3
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47572695_273523982852.0RepeatNote=WD 4
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47572777_281623982852.0RepeatNote=WD 5
HgeneLRBAchr4:151336589chr8:30437913ENST00000510413-47572819_285823982852.0RepeatNote=WD 6
TgeneGTF2E2chr4:151336589chr8:30437913ENST000003559045826_36214292.0Compositional biasNote=Poly-Ser
TgeneGTF2E2chr4:151336589chr8:30437913ENST000003559045837_42214292.0Compositional biasNote=Lys-rich (basic)
TgeneGTF2E2chr4:151336589chr8:30437913ENST000003559045866_146214292.0DNA bindingTFIIE beta


Top

Fusion Gene Sequence for LRBA-GTF2E2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49612_49612_1_LRBA-GTF2E2_LRBA_chr4_151336589_ENST00000357115_GTF2E2_chr8_30437913_ENST00000355904_length(transcript)=8307nt_BP=7471nt
AGGGAAACTTGGAGGCTGCGACCAGGGTTTGGCGTTGTTGTCAGCCTCGGGGAGAGAGATTGGACAAATATTCTCCAAGAGGAGGAGGGC
GACGCCAAGGACTTTCCACATCAACTGCTTTGGGGTATCTCCACAAGTTGGAAGAGGGACCCTTTCGTTTTGCATTGCGTGTGTTGTGCT
CATTACCAGTGCAGCGACTGCCGTCCCAGGGTGACTCTGAGTTGTCCTTTATCGTGAGCTAGCAATGGCTAGCGAAGACAATCGTGTCCC
TTCCCCGCCACCAACAGGTGATGACGGGGGAGGTGGAGGGAGAGAAGAAACCCCTACTGAAGGGGGTGCATTGTCTCTGAAACCAGGGCT
CCCCATCAGGGGCATCAGAATGAAATTTGCCGTGTTGACCGGTTTGGTTGAAGTTGGAGAAGTATCCAATAGGGATATTGTAGAAACTGT
CTTTAACCTGTTGGTAGGAGGACAGTTTGATCTGGAAATGAATTTCATTATCCAAGAAGGTGAGAGTATTAACTGCATGGTGGACCTACT
GGAAAAATGTGACATTACGTGCCAAGCAGAAGTCTGGAGCATGTTTACAGCCATTCTGAAGAAAAGCATACGGAATCTTCAAGTCTGCAC
TGAAGTAGGCCTTGTTGAAAAAGTGCTTGGGAAAATTGAAAAAGTTGACAATATGATAGCAGATCTTTTGGTTGACATGTTGGGAGTGCT
GGCTAGCTATAATTTGACAGTTCGCGAGCTAAAGCTTTTCTTCAGTAAACTTCAAGGAGATAAAGGACGATGGCCTCCACATGCTGGGAA
GTTGCTGTCTGTGTTAAAGCATATGCCTCAGAAGTATGGTCCTGATGCCTTTTTTAACTTTCCAGGAAAGAGTGCTGCAGCTATTGCATT
ACCTCCTATAGCCAAATGGCCATACCAGAATGGTTTTACATTTCATACATGGCTTAGAATGGATCCTGTAAATAACATCAATGTAGATAA
GGATAAACCATATTTGTATTGTTTCAGAACCAGCAAAGGTCTTGGCTATTCTGCTCATTTTGTTGGAGGCTGTTTGATTGTAACATCAAT
AAAGTCAAAAGGAAAAGGCTTTCAACACTGTGTGAAATTTGATTTCAAGCCACAAAAGTGGTATATGGTTACCATAGTACACATCTATAA
CCGATGGAAGAATAGTGAACTTCGATGTTATGTGAATGGTGAGCTGGCTTCCTATGGAGAGATAACATGGTTTGTCAACACTAGCGATAC
CTTTGACAAATGTTTCCTGGGCTCATCAGAAACAGCAGATGCTAATAGAGTATTCTGTGGTCAGATGACTGCAGTTTACCTTTTCAGTGA
AGCTCTAAATGCAGCTCAGATATTTGCTATTTATCAGTTGGGCCTGGGATACAAGGGTACATTTAAATTCAAAGCAGAAAGCGACCTTTT
CCTTGCTGAGCATCACAAACTTTTATTGTACGATGGGAAACTCTCTAGTGCCATTGCATTCACGTACAATCCACGGGCTACAGATGCCCA
GCTTTGTCTTGAATCATCTCCTAAGGACAACCCTTCAATTTTTGTTCATTCACCACATGCACTCATGCTCCAGGATGTAAAGGCAGTTTT
AACACATTCCATCCAAAGTGCAATGCATTCAATTGGAGGAGTACAAGTACTATTTCCACTTTTTGCACAGTTGGATTACAGGCAATATTT
GTCTGATGAGATTGATTTGACTATATGTTCAACCTTGCTGGCCTTTATCATGGAATTGTTGAAGAACTCAATTGCTATGCAGGAACAGAT
GCTTGCCTGTAAGGGCTTCTTGGTAATAGGATATAGCCTTGAAAAGTCTTCCAAATCTCATGTTAGCAGAGCAGTACTTGAACTTTGCCT
TGCATTTTCAAAATATCTGAGTAATCTGCAGAATGGGATGCCCCTGCTCAAGCAATTGTGTGATCACGTTCTTCTTAATCCTGCCATATG
GATTCATACCCCAGCCAAGGTTCAACTGATGCTCTATACTTATCTGTCCACGGAATTCATTGGTACAGTCAACATATATAACACCATTCG
GAGAGTTGGAACAGTGCTTCTCATCATGCACACGCTGAAGTACTACTACTGGGCAGTGAATCCTCAGGATCGAAGTGGTATCACCCCAAA
AGGATTAGATGGACCGCGACCTAATCAAAAAGAAATGCTTTCTCTACGAGCATTCTTGTTGATGTTCATTAAGCAATTAGTGATGAAGGA
TTCTGGAGTAAAGGAAGATGAATTACAGGCCATTCTTAATTACCTACTGACTATGCATGAGGATGACAATCTAATGGATGTCCTACAGCT
GCTTGTTGCATTAATGTCAGAACACCCTAACTCTATGATTCCTGCTTTTGACCAAAGGAATGGGTTACGTGTTATCTACAAACTTCTGGC
ATCGAAAAGTGAAGGAATCAGGGTACAAGCTCTTAAGGCAATGGGTTATTTTTTAAAACATCTGGCCCCAAAGAGGAAAGCAGAAGTCAT
GCTTGGACATGGATTGTTTTCATTGCTAGCTGAAAGGCTCATGCTTCAGACAAATTTAATCACAATGACCACATATAATGTGCTGTTTGA
GATTCTTATAGAACAGATTGGTACTCAGGTGATACATAAACAGCATCCAGATCCTGATTCTTCAGTGAAGATACAAAACCCTCAGATACT
AAAAGTAATTGCGACCCTACTTCGAAATTCTCCCCAGTGCCCAGAGAGCATGGAGGTTCGCAGAGCCTTTCTTTCTGACATGATTAAACT
TTTTAATAACAGTAGAGAAAACAGGAGGAGCTTGCTACAATGCTCTGTGTGGCAAGAATGGATGCTTTCTCTCTGCTATTTTAATCCTAA
GAATTCAGATGAGCAAAAGATAACAGAAATGGTATACGCCATATTCAGAATCCTGCTTTACCATGCAGTCAAATATGAGTGGGGTGGCTG
GCGTGTATGGGTAGACACTTTATCAATCACTCATTCAAAGGTCACTTTTGAAATACACAAAGAAAACCTTGCCAATATATTTAGGGAACA
GCAAGGAAAAGTTGATGAAGAAATAGGGCTGTGTTCTTCAACTTCAGTTCAAGCAGCCTCTGGCATTAGAAGGGATATTAATGTTTCAGT
AGGATCCCAGCAACCAGATACGAAGGATTCTCCTGTCTGTCCTCATTTCACCACAAATGGTAATGAAAATTCAAGTATAGAGAAGACAAG
TTCACTAGAATCTGCATCTAATATTGAACTGCAAACTACTAATACATCTTATGAAGAAATGAAAGCTGAGCAAGAAAATCAGGAGTTACC
AGATGAAGGCACTTTGGAAGAAACACTGACAAATGAGACAAGGAATGCAGATGATTTAGAAGTATCTTCTGACATAATAGAAGCTGTGGC
TATTTCCTCTAATTCTTTTATAACAACTGGCAAAGATTCAATGACTGTCAGTGAAGTAACTGCTTCTATAAGTTCTCCTTCAGAAGAGGA
TGCCTCAGAGATGCCAGAATTCTTGGATAAATCTATAGTAGAGGAAGAGGAAGATGATGATTATGTGGAACTGAAAGTAGAAGGCAGTCC
TACTGAGGAAGCTAATCTACCCACAGAGCTCCAAGATAACAGTTTGTCTCCAGCTGCATCTGAAGCCGGTGAAAAACTGGACATGTTTGG
TAATGATGACAAATTAATATTTCAAGAAGGAAAACCTGTTACTGAAAAGCAAACTGATACTGAAACTCAAGATTCTAAAGATTCTGGAAT
TCAGACTATGACAGCATCAGGGTCTTCAGCTATGTCACCAGAAACTACTGTTTCCCAAATAGCTGTAGAATCAGACCTTGGTCAGATGCT
GGAGGAAGGGAAGAAAGCAACTAACCTCACTAGAGAAACCAAATTAATTAATGATTGTCATGGTAGTGTCTCTGAGGCTTCTTCTGAGCA
AAAGATTGCGAAGTTGGATGTTTCCAATGTTGCTACAGATACTGAGAGGCTGGAGTTGAAGGCCAGTCCCAACGTGGAAGCACCTCAACC
TCATCGACATGTGCTTGAGATATCAAGGCAACATGAGCAGCCAGGGCAAGGAATAGCACCAGATGCAGTTAATGGACAAAGGAGGGATTC
CAGATCTACTGTGTTTCGTATTCCTGAGTTCAACTGGTCTCAGATGCATCAACGTTTGCTCACTGATCTATTATTTTCAATAGAAACAGA
TATACAGATGTGGAGAAGCCATTCAACAAAGACAGTTATGGACTTCGTGAATAGCAGTGATAATGTCATCTTTGTACACAACACAATTCA
TCTCATCTCTCAAGTGATGGACAATATGGTCATGGCTTGTGGGGGTATACTGCCATTGCTTTCAGCTGCTACATCGGCTACACATGAACT
GGAAAATATTGAACCTACTCAAGGCCTTTCAATAGAAGCCTCTGTGACATTTTTGCAGAGGCTAATTAGCCTTGTGGATGTGCTTATATT
TGCAAGTTCTCTTGGCTTTACTGAAATTGAAGCTGAAAAAAGTATGTCATCTGGAGGAATTTTGCGGCAGTGTCTCCGACTAGTTTGTGC
AGTCGCAGTAAGGAATTGCTTGGAGTGTCAACAGCATTCACAACTGAAAACTAGGGGAGATAAAGCCTTGAAACCAATGCATAGCCTTAT
TCCTTTAGGGAAATCTGCAGCGAAGAGCCCAGTGGACATTGTGACTGGCGGTATATCTCCAGTAAGAGATCTTGACAGGCTTCTACAGGA
CATGGATATTAATCGGCTTAGGGCAGTTGTTTTCAGAGACATAGAGGATAGCAAACAAGCTCAATTTTTAGCCTTGGCAGTAGTATACTT
TATCTCTGTTCTTATGGTCTCCAAGTACAGAGACATTTTGGAACCCCAAAATGAAAGGCATAGCCAGTCATGTACAGAAACTGGCAGTGA
AAATGAGAATGTATCACTCTCTGAAATCACACCAGCAGCATTCAGCACTTTAACTACGGCATCAGTGGAAGAATCTGAAAGCACATCATC
TGCTCGAAGGAGGGACTCAGGCATTGGGGAAGAAACAGCCACTGGTTTAGGAAGCCATGTGGAAGTAACTCCTCACACAGCACCTCCTGG
TGTCAGTGCAGGCCCAGATGCAATCAGCGAGGTGCTATCTACTCTTTCTTTAGAAGTCAATAAGTCTCCGGAAACCAAAAATGATAGAGG
AAATGACTTGGACACTAAGGCTACACCGTCAGTTTCAGTTTCAAAAAACGTCAATGTGAAAGACATTCTCCGAAGCTTGGTTAACATACC
AGCAGATGGAGTCACAGTGGATCCTGCCCTTCTGCCACCAGCCTGCCTTGGAGCCCTTGGTGATCTATCTGTGGAACAACCCGTGCAGTT
CAGATCTTTTGACAGAAGTGTCATTGTTGCAGCAAAAAAGTCAGCAGTCTCACCTTCCACCTTTAATACAAGCATACCTACCAATGCTGT
CAGTGTGGTTTCCTCAGTAGATTCAGCCCAAGCCTCAGATATGGGAGGAGAATCACCAGGCAGTAGATCATCTAATGCAAAATTGCCCTC
AGTTCCAACAGTTGATTCAGTTTCACAAGATCCGGTTTCAAATATGAGTATTACAGAGAGGCTTGAACACGCTTTGGAAAAGGCAGCTCC
TCTCCTTCGTGAGATTTTTGTGGATTTTGCACCTTTTCTTTCTCGGACACTTTTGGGTAGCCATGGACAAGAACTGCTTATAGAAGGAAC
AAGTCTGGTTTGCATGAAGTCGAGTAGTTCAGTTGTGGAATTGGTTATGCTACTGTGTTCTCAGGAGTGGCAAAATTCTATTCAGAAGAA
TGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTTGCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGAAGC
TGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAGACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAAACG
AGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAAATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTATCAA
CATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGTGAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGACTT
GCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGACACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGTGTGCATTTT
TAAATTGAGAGAGAACAGCAAAGCCACAGATGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGCTTTAGGAAATCAGAA
CTCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCTTGCCGGTCCTGTTAG
CCTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACTCTATTTTGAGGTGGA
TGAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCTGTTCACAGAGATACG
ATCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGATGTTCAACTTCCCAGA
CCCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAACCAGACGTATTTCATT
AGCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTTGAGTACTTGATGTTTCT
CAACACGATAGCAGGACGGAGTTATAATGACTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGAATCAGAAGAACTGGA
TCTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGA
ATCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGA
ACCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAA
CAGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCT
TGGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATT
GAATTTCAGAAACTGTGGAGGAGTGTCACTGTAGATTCCATGGACGAGGAGAAAATTGAAGAATATCTGAAGCGACAGGGTATTTCTTCC
ATGCAGGAATCTGGACCAAAGAAAGTGGCCCCTATTCAGAGAAGGAAAAAGCCTGCTTCACAGAAAAAGCGACGCTTTAAGACTCATAAC
GAACACTTGGCTGGAGTGCTGAAGGATTACTCTGACATTACTTCCAGCAAATAGGGAACAGTTTTGCCCTGGAACAGAGTTACAGATACA
CAATCAAGAGTGTTCTTGCTGATGCTCGGGGTCTGAAGACTGTCTTCCTATCTGCTTCTTGCGGCTGAGGAGAGGAGCAGTTCAGTTTAC
AAAACAAGTGCAAATTACCAAACTCAAAGCTTATTTGAGTAGAATGGGCTCATGGGCAATGTGATGTTCCCTGTTAACCTTCTGTTACTC
CCTGGGAGAAAGGCGCTGAGCGTGGCATGCAGGTGTCTTTGCTGTGTTTTTCTCCACTTCTAAATGGTTCCTGGTTCCTTTCTTCCTCGT
TTGTTACTTTAGAGCAAGTTTGCCCATAGTCTTGAATGCAATATTTGTTTATTCCAAAAGAACATATTTATAATAAAATCACTGTAGAAG
GATTTTTAAGATGTTAGTGAATTCTGTTTCTTTTCATTCTCGGAAATGGCAGGAAGCAGCTCCAGTCTCTGATTTCCATGGGTCACGTGC
TGGGGATGTGATGAAGCCTGCAGTCTGCACTGTGTTGCTGAGCACATGGATTTCACCACTGGAACACAGGTGTGCTGCTTGTTAGCAAGC

>49612_49612_1_LRBA-GTF2E2_LRBA_chr4_151336589_ENST00000357115_GTF2E2_chr8_30437913_ENST00000355904_length(amino acids)=2419AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD
LSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERL
EHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKD
HLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFW
RLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKD
LENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANR
VAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVI
TNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTF

--------------------------------------------------------------
>49612_49612_2_LRBA-GTF2E2_LRBA_chr4_151336589_ENST00000535741_GTF2E2_chr8_30437913_ENST00000355904_length(transcript)=8504nt_BP=7668nt
AGCACTCGGCGCTGTCATGGCGGCCGGGAGCAGCTTCAGTGGGCACACGACAGCCGCGCGACCCGTGGCGGGGCGAGCTGTGGCAGTAGC
ATCCTCACCACTCGCAGCAGCCTCAGCCGCGGCGCCCGTAGCGCCAGCAGCGGCTGCTTTTGCAAAGGCTGAGCGCAGGGGCGGGGCGGG
CCAGGAAGCCATGGAGTTCTGTGCAGCCGCGGACTCCCGGGGAGCGGACTAGGGAAACTTGGAGGCTGCGACCAGGGTTTGGCGTTGTTG
TCAGCCTCGGGGAGAGAGATTGGACAAATATTCTCCAAGAGGAGGAGGGCGACGCCAAGGACTTTCCACATCAACTGCTTTGGGGTATCT
CCACAAGTTGGAAGAGGGACCCTTTCGTTTTGCATTGCGTGTGTTGTGCTCATTACCAGTGCAGCGACTGCCGTCCCAGGGTGACTCTGA
GTTGTCCTTTATCGTGAGCTAGCAATGGCTAGCGAAGACAATCGTGTCCCTTCCCCGCCACCAACAGGTGATGACGGGGGAGGTGGAGGG
AGAGAAGAAACCCCTACTGAAGGGGGTGCATTGTCTCTGAAACCAGGGCTCCCCATCAGGGGCATCAGAATGAAATTTGCCGTGTTGACC
GGTTTGGTTGAAGTTGGAGAAGTATCCAATAGGGATATTGTAGAAACTGTCTTTAACCTGTTGGTAGGAGGACAGTTTGATCTGGAAATG
AATTTCATTATCCAAGAAGGTGAGAGTATTAACTGCATGGTGGACCTACTGGAAAAATGTGACATTACGTGCCAAGCAGAAGTCTGGAGC
ATGTTTACAGCCATTCTGAAGAAAAGCATACGGAATCTTCAAGTCTGCACTGAAGTAGGCCTTGTTGAAAAAGTGCTTGGGAAAATTGAA
AAAGTTGACAATATGATAGCAGATCTTTTGGTTGACATGTTGGGAGTGCTGGCTAGCTATAATTTGACAGTTCGCGAGCTAAAGCTTTTC
TTCAGTAAACTTCAAGGAGATAAAGGACGATGGCCTCCACATGCTGGGAAGTTGCTGTCTGTGTTAAAGCATATGCCTCAGAAGTATGGT
CCTGATGCCTTTTTTAACTTTCCAGGAAAGAGTGCTGCAGCTATTGCATTACCTCCTATAGCCAAATGGCCATACCAGAATGGTTTTACA
TTTCATACATGGCTTAGAATGGATCCTGTAAATAACATCAATGTAGATAAGGATAAACCATATTTGTATTGTTTCAGAACCAGCAAAGGT
CTTGGCTATTCTGCTCATTTTGTTGGAGGCTGTTTGATTGTAACATCAATAAAGTCAAAAGGAAAAGGCTTTCAACACTGTGTGAAATTT
GATTTCAAGCCACAAAAGTGGTATATGGTTACCATAGTACACATCTATAACCGATGGAAGAATAGTGAACTTCGATGTTATGTGAATGGT
GAGCTGGCTTCCTATGGAGAGATAACATGGTTTGTCAACACTAGCGATACCTTTGACAAATGTTTCCTGGGCTCATCAGAAACAGCAGAT
GCTAATAGAGTATTCTGTGGTCAGATGACTGCAGTTTACCTTTTCAGTGAAGCTCTAAATGCAGCTCAGATATTTGCTATTTATCAGTTG
GGCCTGGGATACAAGGGTACATTTAAATTCAAAGCAGAAAGCGACCTTTTCCTTGCTGAGCATCACAAACTTTTATTGTACGATGGGAAA
CTCTCTAGTGCCATTGCATTCACGTACAATCCACGGGCTACAGATGCCCAGCTTTGTCTTGAATCATCTCCTAAGGACAACCCTTCAATT
TTTGTTCATTCACCACATGCACTCATGCTCCAGGATGTAAAGGCAGTTTTAACACATTCCATCCAAAGTGCAATGCATTCAATTGGAGGA
GTACAAGTACTATTTCCACTTTTTGCACAGTTGGATTACAGGCAATATTTGTCTGATGAGATTGATTTGACTATATGTTCAACCTTGCTG
GCCTTTATCATGGAATTGTTGAAGAACTCAATTGCTATGCAGGAACAGATGCTTGCCTGTAAGGGCTTCTTGGTAATAGGATATAGCCTT
GAAAAGTCTTCCAAATCTCATGTTAGCAGAGCAGTACTTGAACTTTGCCTTGCATTTTCAAAATATCTGAGTAATCTGCAGAATGGGATG
CCCCTGCTCAAGCAATTGTGTGATCACGTTCTTCTTAATCCTGCCATATGGATTCATACCCCAGCCAAGGTTCAACTGATGCTCTATACT
TATCTGTCCACGGAATTCATTGGTACAGTCAACATATATAACACCATTCGGAGAGTTGGAACAGTGCTTCTCATCATGCACACGCTGAAG
TACTACTACTGGGCAGTGAATCCTCAGGATCGAAGTGGTATCACCCCAAAAGGATTAGATGGACCGCGACCTAATCAAAAAGAAATGCTT
TCTCTACGAGCATTCTTGTTGATGTTCATTAAGCAATTAGTGATGAAGGATTCTGGAGTAAAGGAAGATGAATTACAGGCCATTCTTAAT
TACCTACTGACTATGCATGAGGATGACAATCTAATGGATGTCCTACAGCTGCTTGTTGCATTAATGTCAGAACACCCTAACTCTATGATT
CCTGCTTTTGACCAAAGGAATGGGTTACGTGTTATCTACAAACTTCTGGCATCGAAAAGTGAAGGAATCAGGGTACAAGCTCTTAAGGCA
ATGGGTTATTTTTTAAAACATCTGGCCCCAAAGAGGAAAGCAGAAGTCATGCTTGGACATGGATTGTTTTCATTGCTAGCTGAAAGGCTC
ATGCTTCAGACAAATTTAATCACAATGACCACATATAATGTGCTGTTTGAGATTCTTATAGAACAGATTGGTACTCAGGTGATACATAAA
CAGCATCCAGATCCTGATTCTTCAGTGAAGATACAAAACCCTCAGATACTAAAAGTAATTGCGACCCTACTTCGAAATTCTCCCCAGTGC
CCAGAGAGCATGGAGGTTCGCAGAGCCTTTCTTTCTGACATGATTAAACTTTTTAATAACAGTAGAGAAAACAGGAGGAGCTTGCTACAA
TGCTCTGTGTGGCAAGAATGGATGCTTTCTCTCTGCTATTTTAATCCTAAGAATTCAGATGAGCAAAAGATAACAGAAATGGTATACGCC
ATATTCAGAATCCTGCTTTACCATGCAGTCAAATATGAGTGGGGTGGCTGGCGTGTATGGGTAGACACTTTATCAATCACTCATTCAAAG
GTCACTTTTGAAATACACAAAGAAAACCTTGCCAATATATTTAGGGAACAGCAAGGAAAAGTTGATGAAGAAATAGGGCTGTGTTCTTCA
ACTTCAGTTCAAGCAGCCTCTGGCATTAGAAGGGATATTAATGTTTCAGTAGGATCCCAGCAACCAGATACGAAGGATTCTCCTGTCTGT
CCTCATTTCACCACAAATGGTAATGAAAATTCAAGTATAGAGAAGACAAGTTCACTAGAATCTGCATCTAATATTGAACTGCAAACTACT
AATACATCTTATGAAGAAATGAAAGCTGAGCAAGAAAATCAGGAGTTACCAGATGAAGGCACTTTGGAAGAAACACTGACAAATGAGACA
AGGAATGCAGATGATTTAGAAGTATCTTCTGACATAATAGAAGCTGTGGCTATTTCCTCTAATTCTTTTATAACAACTGGCAAAGATTCA
ATGACTGTCAGTGAAGTAACTGCTTCTATAAGTTCTCCTTCAGAAGAGGATGCCTCAGAGATGCCAGAATTCTTGGATAAATCTATAGTA
GAGGAAGAGGAAGATGATGATTATGTGGAACTGAAAGTAGAAGGCAGTCCTACTGAGGAAGCTAATCTACCCACAGAGCTCCAAGATAAC
AGTTTGTCTCCAGCTGCATCTGAAGCCGGTGAAAAACTGGACATGTTTGGTAATGATGACAAATTAATATTTCAAGAAGGAAAACCTGTT
ACTGAAAAGCAAACTGATACTGAAACTCAAGATTCTAAAGATTCTGGAATTCAGACTATGACAGCATCAGGGTCTTCAGCTATGTCACCA
GAAACTACTGTTTCCCAAATAGCTGTAGAATCAGACCTTGGTCAGATGCTGGAGGAAGGGAAGAAAGCAACTAACCTCACTAGAGAAACC
AAATTAATTAATGATTGTCATGGTAGTGTCTCTGAGGCTTCTTCTGAGCAAAAGATTGCGAAGTTGGATGTTTCCAATGTTGCTACAGAT
ACTGAGAGGCTGGAGTTGAAGGCCAGTCCCAACGTGGAAGCACCTCAACCTCATCGACATGTGCTTGAGATATCAAGGCAACATGAGCAG
CCAGGGCAAGGAATAGCACCAGATGCAGTTAATGGACAAAGGAGGGATTCCAGATCTACTGTGTTTCGTATTCCTGAGTTCAACTGGTCT
CAGATGCATCAACGTTTGCTCACTGATCTATTATTTTCAATAGAAACAGATATACAGATGTGGAGAAGCCATTCAACAAAGACAGTTATG
GACTTCGTGAATAGCAGTGATAATGTCATCTTTGTACACAACACAATTCATCTCATCTCTCAAGTGATGGACAATATGGTCATGGCTTGT
GGGGGTATACTGCCATTGCTTTCAGCTGCTACATCGGCTACACATGAACTGGAAAATATTGAACCTACTCAAGGCCTTTCAATAGAAGCC
TCTGTGACATTTTTGCAGAGGCTAATTAGCCTTGTGGATGTGCTTATATTTGCAAGTTCTCTTGGCTTTACTGAAATTGAAGCTGAAAAA
AGTATGTCATCTGGAGGAATTTTGCGGCAGTGTCTCCGACTAGTTTGTGCAGTCGCAGTAAGGAATTGCTTGGAGTGTCAACAGCATTCA
CAACTGAAAACTAGGGGAGATAAAGCCTTGAAACCAATGCATAGCCTTATTCCTTTAGGGAAATCTGCAGCGAAGAGCCCAGTGGACATT
GTGACTGGCGGTATATCTCCAGTAAGAGATCTTGACAGGCTTCTACAGGACATGGATATTAATCGGCTTAGGGCAGTTGTTTTCAGAGAC
ATAGAGGATAGCAAACAAGCTCAATTTTTAGCCTTGGCAGTAGTATACTTTATCTCTGTTCTTATGGTCTCCAAGTACAGAGACATTTTG
GAACCCCAAAATGAAAGGCATAGCCAGTCATGTACAGAAACTGGCAGTGAAAATGAGAATGTATCACTCTCTGAAATCACACCAGCAGCA
TTCAGCACTTTAACTACGGCATCAGTGGAAGAATCTGAAAGCACATCATCTGCTCGAAGGAGGGACTCAGGCATTGGGGAAGAAACAGCC
ACTGGTTTAGGAAGCCATGTGGAAGTAACTCCTCACACAGCACCTCCTGGTGTCAGTGCAGGCCCAGATGCAATCAGCGAGGTGCTATCT
ACTCTTTCTTTAGAAGTCAATAAGTCTCCGGAAACCAAAAATGATAGAGGAAATGACTTGGACACTAAGGCTACACCGTCAGTTTCAGTT
TCAAAAAACGTCAATGTGAAAGACATTCTCCGAAGCTTGGTTAACATACCAGCAGATGGAGTCACAGTGGATCCTGCCCTTCTGCCACCA
GCCTGCCTTGGAGCCCTTGGTGATCTATCTGTGGAACAACCCGTGCAGTTCAGATCTTTTGACAGAAGTGTCATTGTTGCAGCAAAAAAG
TCAGCAGTCTCACCTTCCACCTTTAATACAAGCATACCTACCAATGCTGTCAGTGTGGTTTCCTCAGTAGATTCAGCCCAAGCCTCAGAT
ATGGGAGGAGAATCACCAGGCAGTAGATCATCTAATGCAAAATTGCCCTCAGTTCCAACAGTTGATTCAGTTTCACAAGATCCGGTTTCA
AATATGAGTATTACAGAGAGGCTTGAACACGCTTTGGAAAAGGCAGCTCCTCTCCTTCGTGAGATTTTTGTGGATTTTGCACCTTTTCTT
TCTCGGACACTTTTGGGTAGCCATGGACAAGAACTGCTTATAGAAGGAACAAGTCTGGTTTGCATGAAGTCGAGTAGTTCAGTTGTGGAA
TTGGTTATGCTACTGTGTTCTCAGGAGTGGCAAAATTCTATTCAGAAGAATGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGG
TTGCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGAAGCTGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCAC
AGACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAAACGAGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCA
AAATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTATCAACATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCA
GTGAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGACTTGCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCG
ACACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGCCACAGATGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAG
GCTTTAGGAAATCAGAACTCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAAT
CTTGCCGGTCCTGTTAGCCTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAA
CTCTATTTTGAGGTGGATGAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGG
CTGTTCACAGAGATACGATCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTG
ATGTTCAACTTCCCAGACCCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAA
ACCAGACGTATTTCATTAGCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTT
GAGTACTTGATGTTTCTCAACACGATAGCAGGACGGAGTTATAATGACTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTAT
GAATCAGAAGAACTGGATCTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTC
TTCGCTGAGCGTTATGAATCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCA
TGGCTGCTAAGAATAGAACCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATT
TCCAGAGCTTGGCGAAACAGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAAC
TTCAATAATTATAATCTTGGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTT
GTTCACATAAACAGATTGAATTTCAGAAACTGTGGAGGAGTGTCACTGTAGATTCCATGGACGAGGAGAAAATTGAAGAATATCTGAAGC
GACAGGGTATTTCTTCCATGCAGGAATCTGGACCAAAGAAAGTGGCCCCTATTCAGAGAAGGAAAAAGCCTGCTTCACAGAAAAAGCGAC
GCTTTAAGACTCATAACGAACACTTGGCTGGAGTGCTGAAGGATTACTCTGACATTACTTCCAGCAAATAGGGAACAGTTTTGCCCTGGA
ACAGAGTTACAGATACACAATCAAGAGTGTTCTTGCTGATGCTCGGGGTCTGAAGACTGTCTTCCTATCTGCTTCTTGCGGCTGAGGAGA
GGAGCAGTTCAGTTTACAAAACAAGTGCAAATTACCAAACTCAAAGCTTATTTGAGTAGAATGGGCTCATGGGCAATGTGATGTTCCCTG
TTAACCTTCTGTTACTCCCTGGGAGAAAGGCGCTGAGCGTGGCATGCAGGTGTCTTTGCTGTGTTTTTCTCCACTTCTAAATGGTTCCTG
GTTCCTTTCTTCCTCGTTTGTTACTTTAGAGCAAGTTTGCCCATAGTCTTGAATGCAATATTTGTTTATTCCAAAAGAACATATTTATAA
TAAAATCACTGTAGAAGGATTTTTAAGATGTTAGTGAATTCTGTTTCTTTTCATTCTCGGAAATGGCAGGAAGCAGCTCCAGTCTCTGAT
TTCCATGGGTCACGTGCTGGGGATGTGATGAAGCCTGCAGTCTGCACTGTGTTGCTGAGCACATGGATTTCACCACTGGAACACAGGTGT

>49612_49612_2_LRBA-GTF2E2_LRBA_chr4_151336589_ENST00000535741_GTF2E2_chr8_30437913_ENST00000355904_length(amino acids)=2408AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD
LSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERL
EHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKD
HLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFW
RLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLS
TPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPA
TVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLT
LPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LRBA-GTF2E2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LRBA-GTF2E2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LRBA-GTF2E2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource