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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRBA-ZNF704 (FusionGDB2 ID:49631)

Fusion Gene Summary for LRBA-ZNF704

check button Fusion gene summary
Fusion gene informationFusion gene name: LRBA-ZNF704
Fusion gene ID: 49631
HgeneTgene
Gene symbol

LRBA

ZNF704

Gene ID

987

619279

Gene nameLPS responsive beige-like anchor proteinzinc finger protein 704
SynonymsBGL|CDC4L|CVID8|LAB300|LBAGig1
Cytomap

4q31.3

8q21.13

Type of geneprotein-codingprotein-coding
Descriptionlipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containingzinc finger protein 704
Modification date2020032020200313
UniProtAcc

P50851

.
Ensembl transtripts involved in fusion geneENST00000357115, ENST00000507224, 
ENST00000510413, ENST00000535741, 
ENST00000503716, 		ENST00000520336, 
ENST00000327835, 
Fusion gene scores* DoF score31 X 32 X 15=148805 X 5 X 4=100
# samples 416
** MAII scorelog2(41/14880*10)=-5.18160680648995
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRBA [Title/Abstract] AND ZNF704 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRBA(151935578)-ZNF704(81605342), # samples:1
Anticipated loss of major functional domain due to fusion event.LRBA-ZNF704 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LRBA-ZNF704 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRBA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF704 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HDLRBAchr4

151935578

-ZNF704chr8

81605342

-


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Fusion Gene ORF analysis for LRBA-ZNF704

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000357115ENST00000520336LRBAchr4

151935578

-ZNF704chr8

81605342

-
5CDS-5UTRENST00000507224ENST00000520336LRBAchr4

151935578

-ZNF704chr8

81605342

-
5CDS-5UTRENST00000510413ENST00000520336LRBAchr4

151935578

-ZNF704chr8

81605342

-
5CDS-5UTRENST00000535741ENST00000520336LRBAchr4

151935578

-ZNF704chr8

81605342

-
Frame-shiftENST00000357115ENST00000327835LRBAchr4

151935578

-ZNF704chr8

81605342

-
Frame-shiftENST00000535741ENST00000327835LRBAchr4

151935578

-ZNF704chr8

81605342

-
In-frameENST00000507224ENST00000327835LRBAchr4

151935578

-ZNF704chr8

81605342

-
In-frameENST00000510413ENST00000327835LRBAchr4

151935578

-ZNF704chr8

81605342

-
intron-3CDSENST00000503716ENST00000327835LRBAchr4

151935578

-ZNF704chr8

81605342

-
intron-5UTRENST00000503716ENST00000520336LRBAchr4

151935578

-ZNF704chr8

81605342

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000510413LRBAchr4151935578-ENST00000327835ZNF704chr881605342-144345014871518343
ENST00000507224LRBAchr4151935578-ENST00000327835ZNF704chr881605342-144445114971528343

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000510413ENST00000327835LRBAchr4151935578-ZNF704chr881605342-0.0028508020.99714917
ENST00000507224ENST00000327835LRBAchr4151935578-ZNF704chr881605342-0.0028528720.99714714

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Fusion Genomic Features for LRBA-ZNF704


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRBA-ZNF704


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:151935578/chr8:81605342)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRBA

P50851

.
FUNCTION: May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF704chr4:151935578chr8:81605342ENST0000032783519383_38773413.0MotifCR1
TgeneZNF704chr4:151935578chr8:81605342ENST0000032783519401_40573413.0MotifCR2
TgeneZNF704chr4:151935578chr8:81605342ENST0000032783519318_41273413.0RegionSufficient for binding to RE2 sequence motifs
TgeneZNF704chr4:151935578chr8:81605342ENST0000032783519193_21873413.0Zinc fingerC2H2-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2581006_1053722864.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2571006_1053722852.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2581990_1994722864.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2571990_1994722852.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2582073_2181722864.0DomainBEACH-type PH
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2582200_2489722864.0DomainBEACH
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2572073_2181722852.0DomainBEACH-type PH
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2572200_2489722852.0DomainBEACH
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2581301_1343722864.0RepeatNote=WD 1
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2582591_2633722864.0RepeatNote=WD 2
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2582636_2679722864.0RepeatNote=WD 3
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2582695_2735722864.0RepeatNote=WD 4
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2582777_2816722864.0RepeatNote=WD 5
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2582819_2858722864.0RepeatNote=WD 6
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2571301_1343722852.0RepeatNote=WD 1
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2572591_2633722852.0RepeatNote=WD 2
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2572636_2679722852.0RepeatNote=WD 3
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2572695_2735722852.0RepeatNote=WD 4
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2572777_2816722852.0RepeatNote=WD 5
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2572819_2858722852.0RepeatNote=WD 6
HgeneLRBAchr4:151935578chr8:81605342ENST00000357115-2581531_1548722864.0TransmembraneHelical
HgeneLRBAchr4:151935578chr8:81605342ENST00000510413-2571531_1548722852.0TransmembraneHelical


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Fusion Gene Sequence for LRBA-ZNF704


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49631_49631_1_LRBA-ZNF704_LRBA_chr4_151935578_ENST00000507224_ZNF704_chr8_81605342_ENST00000327835_length(transcript)=14444nt_BP=511nt
CCTGCCCTGGATCTCCGCCGCCACCTCGGTCTCGCTGCTCCTGGGCGGGGGGTGAGGACGAGTCCGGAGTATCTGGGGTTTGGCGTTGTT
GTCAGCCTCGGGGAGAGAGATTGGACAAATATTCTCCAAGAGGAGGAGGGCGACGCCAAGGACTTTCCACATCAACTGCTTTGGGGTATC
TCCACAAGTTGGAAGAGGGACCCTTTCGTTTTGCATTGCGTGTGTTGTGCTCATTACCAGTGCAGCGACTGCCGTCCCAGGGTGACTCTG
AGTTGTCCTTTATCGTGAGCTAGCAATGGCTAGCGAAGACAATCGTGTCCCTTCCCCGCCACCAACAGGTGATGACGGGGGAGGTGGAGG
GAGAGAAGAAACCCCTACTGAAGGGGGTGCATTGTCTCTGAAACCAGGGCTCCCCATCAGGGGCATCAGAATGAAATTTGCCGTGTTGAC
CGGTTTGGTTGAAGTTGGAGAAGTATCCAATAGGGATATTGTAGAAACTGTCTTTAACCTGGAAATCTTCAGAGGAACTAGACATGGACA
AGGTGACAGCAGCAATGGTACTAACCAGCTTGTCGACTAGCCCTTTGGTTCGAAGTCCTCCCGTGCGGCCGAACGAGAGCCTCAGCGGAT
CCTGGAAGGAGGGCGGCTGCGTGCCTTCCAGCACCAGCAGCAGCGGCTACTGGAGCTGGAGCGCCCCCAGCGACCAGTCCAACCCGTCCA
CGCCGTCGCCGCCGCTCTCGGCTGACAGCTTCAAGCCCTTCCGCAGCCCCGCGCAGCCAGACGACGGCATCGACGAGGCGGAGGCCAGCA
ACCTGCTCTTCGACGAGCCCATTCCCAGGAAAAGAAAGAATTCCATGAAGGTGATGTTCAAATGCCTCTGGAAAAACTGTGGGAAGGTGC
TGAGCACTGCAGCAGGTATCCAGAAACACATCCGAACCATCCATCTGGGGCGCGTTGGAGACTCTGACTACAGTGATGGAGAAGAGGACT
TTTACTACACTGAGATCAAGCTCAACACAGACTCAGTGGCAGACGGGCTGAGCAGCCTGGCCCCGGTCTCACCTTCCCAGTCCCTGGCTT
CACCTCCTACTTTCCCCATCCCAGATTCAAGCCGAACAGAAACTCCTTGTGCCAAAACGGAGACTAAGTTGATGACGCCGTTGAGCCGCT
CAGCTCCCACCACCCTCTACCTCGTGCACACTGACCATGCTTACCAGGCCACACCCCCTGTGACCATTCCAGGATCGGCCAAGTTCACCC
CCAATGGCAGCAGCTTCAGCATTTCCTGGCAATCTCCTCCGGTCACTTTCACAGGCATCCCAGTGTCACCCACACATCATCCGGTGGGCA
CAGGAGAGCAGAGACAGCATGCGCACACGGTCCTGTCCTCCCCACCCAGAGGCACAGTCAGCTTAAGGAAGCCCAGGGGAGAGGGCAAAA
AGTGTCGGAAGGTGTACGGGATGGAGAACCGAGACATGTGGTGTACCGCCTGCCGCTGGAAGAAGGCCTGCCAGAGGTTCCTCGACTGAG
AGACCCCCAGGCAGAGGGGCTCAGGGCCCTGAGCCGCTCCTGCCCTGGCCTGCCACTGCAGGTGTTGGAAAGAGCTTTTCCTACTGAATA
AAACACAGTTGAAGCCAGGAAAAGCCCTTTCAGGAACCTTGGAGGAATAACAGCAAAAACACAGAAAAATTGTTTAAGTCACCACCTATG
ACAAAAGAAAGTTGCTCTTACTGAGAACCCAGCTTGGAGCAGCTATAACTAGTTTTTTTTCCTTCAAAAGAAAAGTCAACTTTTTTTGCT
GTATGTCTAGACTTAAAACTGTGGACTTCTGTAGCAATTGAACCAACAAAGCCCATTTTACCTAGAAAGGAGGCATATTTTGATAAGCTT
TCTGAATTATGCCATTTTCAAGATTTTTTTGACACTTAAAAAACAAGCTACAGGTTATTCAGTAGCATTTGTACAAAGATCAATACTTAC
TTTTGTTGTGAATAATCTTTTCCGTATCTTCCATTTGACTTCTTGGAGCAGTATATGTCAGGATGTGTTGCAAGACAGCGCAGCACTCTG
GGCATCTTTTCTATGGCTTTTTGTTTGTTTTTCTTTTAAGAATGGCCCCACACTGAACCATGGTAGAGCTATTAGTTTGTAGGGCCCCAG
ATGGCATAAACTCGAGAAGGGATTGTCCACGGAAATCACCAGCAGACTTCAGCCCGAAGCTGAGTTCAGGAAGTCCAGCTGTCACTGTTG
GGAAACATCTAGGAGTCTTCCTTGGATCCATAAGAAGCTCTTCCCCTAAAGGCAGCACAGCTAACTCTACTCTCTACCTGCCACAACTCA
GTCAAGAATTGGCACCTGTAGCCATCTGGGTAAGCCTCGATGCTTCTTTCAGGGATGTGACACAAATGGCAACTCGGAGCTATTTGTTAC
TGCTTGTCTGTCAAGATTGTAGCCAGGTTAATGGGTCATTTTCCTTCTCTCCAGACTCCACCACTGACTGATTTCAGAAGAGGTAGAGAA
CTCCAAACTGTCCCAGCAGGTTTGCTTTAGACAACAGAGCACAGCCCACATGGCCCTACCTGTTCAGAAAGTCATGTTAGATCAACAAAC
CACTTCCATTCTGAGTGCACTTTTATAGGTTTTATGCTTTAGCATGTCCGGGAGATGAGTTAATTAACAATATAAACATTATGTGAGTAA
ATGGAAGGTCCAAACTTTAAGTTTTTCTTATAAAAATATTGGAGCTATTCATTTAAGAATTTGCTCAAAAGGGAACATAACGCCAAAAGG
AAAATGCATGTAGGTATAGGAATTTCTCAGTTTAGTAGGGCCAGGGCTTGCACTATGTTCCATTTATTGGGCTTCGTAACTTACTTGCTT
GTTTGTTTGGGGGATAGTGGTGTGGGGAGAGGGGAGTCGTCAAGCCCTATAAATAAGCTCATTCTCTATCTACCCGACTCTCAATTGCCC
TGCTAAAGAGTTATTTCTCCTATACCTATGCAAAGTAGGAAGAGCACCTTATAGGAGGCACTGTATAGGGACAGGGGACATGGGATCAGC
CATAGGAATGTTAAATGAAATTGCACAGAGGAAAGTTTAATATATGTCTAGAGATTATACATACACTTTTTTAAGCGTAAAAAGAAGACA
TCTAGTAATGACAGATATTCTTTTTATATACAAGCAAAAGAAAGTATAAGGAGGTTCTACAGTGCAACATCCACAATCTGTGCATTCACA
TATTATGGGACTTTTATTTTTTAAACTCTCATATAAATTTTTTAAAATTACTCCTTGGAAGAGATCCTGGTTTTTTTCTTCATTTATTTT
TTTCTTTAAAAACATTTATTTTAAGAGAAGAGAAAAAGAGCTTCATCTAATTTTGCATCTTGATTACCAATCAGTACTAGTCACAGCACC
AGCAATACTGTATGTTTTAGACTGACAAGGTCAGCCAGGAAATGGCATTTTTTTAAACGCAGAAATGTGTTTGTTTCCTCTACTCTAACA
CGTCCTTTCTCCTCCTGGTGTCCTGTCACCCCCCATGCAGCACCACTGATGCGAGATGATGCTCTGGCCTGGTCCAGGAAGCCCTGAGCC
ATGGGCAGATTGCCCAGTGGCCTTGGGCGGCCAGAGCTTGTCACCTGTTTAAACAAGTTCACCATGTGTTTAAATGACAGGGTACAGTCC
TGGACCAGAGGTTTTTCTCTTCAGCAAAGCTCCCTGGCCCTTGATCGTTGGACTGTTACTAATAGAAAAAGATTCAAGTCATGAAGTATA
AAATCCATCCCCCATCCCAGAACTTTGAAACACAAGGAGGGAGAGATCTTTGCTATGGAGCAGTCCTGGAGCAAAGCCCCGTGGCTTCCA
CCCCCAGATATATACCCCATAAGTAGTGCTGAGCTCCAGCTTAGCTGAGCCAAGCTCAGTCCTTATCTGGTGTTCAGCCAGTGCACAGGT
ATAAGCAGAACTACAGAGCTGAATGTAGCTTCCCTGGGATCTCTTCTCCTTTCTAAAGCATTTTTCACACAGTTCTGTACCTCCTACCCA
AGTTGGGGCTGCTTTCTGCCTGCTAGCCCACGGCTCTGTGTACTTTCTTTTCTGGCTTCAGGTGCAGACAGACCCTCAGTACCTTCCTGG
ACACAGACACATATTCCCTGGACCAAGGCGTGGAATAACTAGTAGACCACCAAGCCACAGGTGGCTGGTCTTGAAGAAAAGGGATTATAC
TCCTTACAGGCCACCCAGAAAGCTATGAATTCCAATATACACCACTGATCGTGCAAGTTAGGGTTTTTTTTTTTTAAACGTAGCATTATT
TTGTTATATTTTGGAACTAAATGAAGTGCCAAATTAACCAGACATTCGTTTGATGCCATCTCTGTGGAACCAAGTTCTCTGTGTGTGTTC
GTTTGGCTGGGAGGAGGGGGAGGACTGGGCAGACTGCTCCCACAGCAGGCTGGCAGTGGAACTGGAGCCCTGGCCACCGCAGGGAGCTCA
GAGGCCAATCTACGCAAAAGGCATGCAAAACAATGGATTCTGGTCCCAAAATATTTCTAAGTAAGGCATGATGTAGCCTTTTGATTTTTT
TTTTATCCTTTGACACCCCAGCCTTCAGAAAAGGTTTTTCATCTCTCTCCAAAGAAGTCATTTCATAGTGACTGACAGGACATTCTCCAG
AGAGCGACAAAGCAGAGTGGCCAGCAGGCAGTGGTGTTAAGCCTTGGGCCTTCCCAGCAGATGTGTGCTGCATTGGTGGGTGGGAGGCAG
TGTGACAGCCTGGAGAAAACACACAGGTAGCAAGGGAGTCAGGGGGGAGGTACAAGAGGGCTGTGGACACCTGGCTCTTGCTCATCTTCT
TGGTGCTGATCAGCTGGTGGTCACCATCCCTAAGTACCTCCCAGGGAGCTGCCATTTTCTCCTCTGGGAGCAGCTGCCTGAAGCAAGGAG
AGAATGACCTGAAGGGAAGTACCTCCGGCCAAGAGTGCAGGGCTGCTGTGCCTAGCCTGAGCGGGCCATCTCTAGCAGATATGGACTTCT
CTCCACCACACTAGCTGAAAAGTTTTCTCCCTTGGTTGGCAAAAGCCAGTGTCAGGAAAAAAGCTGTGGGTTTCTGACCAAGAATGTGTG
CGCTTAGCTGCAAAGTGCCTGTCAGCAGCTCCAGGCACCAACAAGGTGCCCTTTTATTAGACAATTCCTGCCCGAACATAACCATATTGC
AGATGAAAATTTTCAATAGAGAATGACACAATTCTTGACCTTTCTAAAAACTTTTCAAAGAGATAGTCACATGTGTATATGTTGCAAAAG
ATTTTTGAAACTGAAATGTCCTCCATTAAATCTCAAGAGCACTCGAGTTTTAAGTCTGCTGTTTCTGGTGTCACACTAAGACACACTTTT
GAAAGCAGCCCTGGGTTCTGAATTAGTTGGCACTGCTGAATCCATGTTCCCCCTTCATCAGACTCCAAAGTGCAGCATTCACTTGCAAAG
GTTGAGAGAAAAGTGGCCAGAATTGTACATATAACAGAGAATACCTTGAGAATAGTAGCAAAATACTGTAAATAATATTCATTTCCTCAG
GGAAAAATAAAGGGCATGCAAAAATAGGTCTGGAGACTCCTGAAACTAGGAAGAATTTTGTTATCACTAAAGTCTTTTATAGTCAGAACA
ATTTTTTTTTCAAATGAACATGGTATCATTTCAAGACAAATTTATGTGAACTGGGCAGTACTGACATTTGTGAGGCATAGGGGAGTGCCC
TGGGAAAACGGTTTGGAGCTGACCTGTAGCCTAAGGCTAACATTTGAACCACAGGTGCAATGCCTGGGGGTGGGGGAGGGGGACGGGGTG
GGGGTGGTATTCCTAGACTCACGTAAGGCTTTTTCTGAATGTAATTGTGAATACAAAGCCTTGCTGGTCCTTTTTATCATTACCCAATGG
ATGACTGTTTATTAGCTATCAGCAGAATTCCGTAGGCGAAAGCAAGCCGTGAACGATGTACATTTTGCTTTAATAGCATGTTAGCGAACA
AACTTCCATGGACTTTTGTGGACAAGGTGCTGCTTTTTCTCATGACCCTGTAGAATTGCTATCGACCACATCTTCTGTAGCACTGACCTG
TGTGAACTCAGGGAAGAATTTGTGCATACAAATGAGTGGAAACAGAGCAGGATTCATGAATATGAATGAGAATGTGAATCATTTTGGAGA
ATGCCCTGGGCACACGGGTCAACTGGAAATTTCATTTCTCTAAGAAAGTAGCCCTACCAGCGGCACGGACTGTTCCTGTTCCTCATACCT
GTGGGGATTCCTCCATATTGGAACTGTTTCATGTATCTTTTTTGCATTGTAACTAGCCAAACCTGAAGTCAGTAAATAAAATGAGATTAG
CACTTTTTTTAGGTACCAGTTGTATCACTGAGTAATGCACACCAATAGAGCAAGAAAGTATAAAATGTATTTAAGACCAACTGGTTTGCT
TATTATGACTGACTTTGAAAAAGCCCATATCCAATGATATACATGCTTTAAAAGGTATATCTATCGTAGGACCAGGAACCAAAATGGGAA
TTTTACTTCTGGTCCTGTTTTGTAAATAGTTCCTTTTTTTGAAGACAATCTCATGTTTTATAACTTTTGTTGTGGGTCTGAGAATCACAA
TGGTAATATGTCTTGGCAAAACATAACCTTTAAATACAAAAACAATTATAACTTAATTTTCCAAATAAAACAAGAAATACACTGATTAGG
CTTCTACAGTTCTAAGAGACATGACACTTTGGTAATAAGCGTCAGTACTCTACTTCTCAAGTTAACTGGAAATATTTTACAAGATGCAGT
GTTTTGTAATCACAAAGAACGCAGACATTTTGTGAGAAATGACCTTGGTTTTATACATTGTAGCTTATTTTTTAAAATATAGTATTTTAC
CAGGCAGGAAGTATTAATATTATAAGTAATTCTTGCTCACCAAACAAAGGGCTATGTCTCTTTTAAGCAAATGTTTTGATGCATATCTTT
TTAATTAACCCTCTGCAGCAAGGGTAGAAATACAGATCAGATGGAATGGGTATTATAGGAGAATCAAGATAGCAACAGCTACTCCTTTTA
CCATTACTAGTGTGTTTTCAAAGTATGGAAAAAGATGCCTGAAGAGTCATTTTATATATTTTAAATCTAAAAAGTGTTAACAGGTATGCT
TATAGGCCATGGGAGAAATATTCTTATAAATTTTTTAGTGTAAAATGATAAATTCTGTGTCACAAAGACAAGTTTACCACTTGACCTACC
AGAATCACAGATACTTGCATTTAACTAGCAAGTATCATTTGGTGGAAATTTCTAAAATCATAGTAGACAGGCCCAAAGATAGAATTCTTA
GGTGATCAGTAGTGTTTAAAATAATTTTGTCCTCAGCACTAACTATATAACTGTAATTTCTACATAAGAACAAGTGCTTCCAAAATATAG
TGGAGGGAAAAAATAAAAAAGGAAAATAAAAAAACAAAACAAAAAGAACAAGTGCTTGATTTTTCACTGTGAAGAACTAGCAGGCACATG
AGGTTGTGATCAGAAAGTGACTGAGTTCCCAAGAACCAGGAAACAGAGGGGAGTTGTGAAGAGTTTATTAAAACTGTACAAATAATTCAG
AGCTTTGCCAAAACCATTTCATAATGCTGTACAGTTTTTTCAAGCCCACTCACTGTTAAAACAAGAAAGCACCTTTTCTTTCTAAGATTT
TAGTAATCCAAAAGCTAGCCTAATTAGCCAAGTATGCAGATAACATCAAAAGCAAAGCTGAGATAGAACAGCCATACACCCGTTGGGCAG
CTCTTATGAGGTGGTCAGAAGGTCACTCAGACCTTGGTTTCAAATAGGCTTTAGAATCTGCACACTTGAGGACTAGAAATGCACAGAGTT
AGGGAAAGCCATGTACAGGCTTGGCTCCTAGTCTTTGAGATGAGGCGTCTTGCAAATCTCTGTTTTCACTCCTTGGAATGTCTCCATTGT
TAGCATTAAAGTCCCCAAGAAGTTTTTATTGCTGTACGGTTTTGAACCCAATGAGTCTCATTTCCAAAAGATTCCTAATTCTATATAGGA
GAGGTTGCAAATGTCAGTGCCTCAGAAGGACCAGGCAAGTTCTGTAAATGATTGATGTGGATAAGGCAAAGAGGAACACAAGAATGGTGG
AGACCAGGTTGAACTGCAGAACACATGCCCTCTTTGAAGGGGTGCCCACACTCAGCTCTAGACAATCAGAACCATGCAGAAATCAGGCCC
AGGGCTGCTAGATCTTCTGACGTGGAAGTATGATATTACCTGACACGTAAGTGTTGACAACTAACTCAAACTCTTGGCCAACACTGTGCA
GACCAAAGAGAAGCTGTACACAGACAGGTGCAGCCTGCAGCCCCCAGTTTCAACTATTGGGAAAAGTGGATTTCACATTCCACAGTTGTC
AGGTCAGGTTCATCCATCAGCCCCACAAACTCACATGTCGGCACTATCTGGGCAACTAAAATAAAAGAGGGGAAAGAGATCATTTCTCCC
CAGATATCATTCTCATGGCAGACTTGAATATAGATACGCTGAGTTATCCAGCTCTCTCACTCTGCCTCCTTTTGGCATGCCCAGGCTGTG
CCCCGTAAAGTGTTGAATCACTGTTATCCTAATTTTCTTAGTGTTTTCTACCGTGGCCACTGTGATGAGGGGCTGGCAAAGAGCAGCCTC
GTGCCTTCCGAGAAGGCTGCCAGGAGCCTCTGAAGCTTGAAGCGAGCACACATTGCCTCCTTGTGCCAAAGCCCTTGGCCAGCCTCCCCA
CACTCCTTCCCTCTCCATCCGGCCTCATGAGTCTTCGTTACCAAGTAAAATTACCACTGCTTCACCTCTGATACAGCAGAAGCCTTGCTT
CAGAACTGGTAGGCATTTAGGCTATTTCAGAGTGTCCACTAACCTCAAAAGGAGGTTTTTCCACATACAAAACCCTAGCATCTTTGAGGG
GAAAGCAAAATGAGAATAAATTATGTCATGAAAAAAATTAGAAGTTGCTTCCTTCATTTAGATGGACTAAGTTATTTTAAACTCTATCTT
ACATCAGAGTCCTGATGGTGTTGGGATAGTCACTGACCCTTTCACGTATGTAATAAGATACGTCTCGTTCACACACTATTTCATTTGATC
TTTGTAAGAACCCAGTGTAGAATAGGAATATTTAAAATCAACATTACCCACCTCCAAGGCCAACCCAGAGTAGTCTTGAACCTGAGTCAG
CCTCAGTATTGCTTGCAAGGAAGAGGGAAGGGGCTCATTAAAGGCCTGGCTCAAACCTTAGTCTTCCAGACTGACTAGGGACGTAAGAAG
ACCCAGGGACCCACCATGTTCTCAAACCATCTATTCAGTCCAGGCCTTTCAGCATAGACATAAAGAGCCCACCCGTTACTCAGTCATGTT
GCCAAGTGCAAACTGATTTATCCCCAGATGAATCCCTTTACTGTAGCAGATCCCTAATCCCTAAATTTCAGCCAATTTGGTAGTTAATTA
TAGGAGTTTATTAGCTAAATGTATGTTCTGAGTAAAAGTTTTGACTCTTTGGGGAAAATTTATTTTGCTGCTAGCATACAACATTTGCTA
TGTATATAAACTTAAGTCAATGCCAGAAATTTTAAAACCAGCTCAAATTTATAATCTGTAATGATCAAATCAAAACATACTGTAAACTCA
GAGTTGGAAACGCCTGGTAATATGGTTAAGTCATGTTTAAATATGAATGCAATTTAAATGACATTGGCAATGCCTGAGATTTCTTTCATT
GTGAATGATTAAAAGGCAGTCCAATATATGAATGGATTTCATCTTACCTTTCTCCCGTTAATTTACTAGGTGTAACATCTTGAGTGTAAA
GTCATTCACAGGCAGTTGGGTTGTGGAGCTAGAAGGAGCCTCAAAAAAAAACTTTTTGGCCAGACTCCTACATCATGAACAGGGTTTTTG
ATGAATAATATTTATTATTATGTTTCTAAAGTAATACAGTGTTGGAGAATGAAACAGTTTAGTCCTTTCCTCTTCTGATGGAAAAGAATC
ATAGCGCCGTTGCCATGACAATAACAGGATGTAGAAAGACCCATGAAGAAAGAAAGAAGAAAGCTATGGTTCCGAAAGCAGGTAACCACA
GATTTTGAAAGGAGGCAGAGATGGTGATTAAACTGTAGTCCTTGTTTTTTAAAATGTTCTTTCATGTTAGGCACCACCACATAGTTAATA
ACTACCAACTTCTAAAGAGAAGATCCCCTTGATTTATTTATATCATGAAAATACTAAAAATCAATTCTCAAGTCTAATTAACTATTACAT
TATCTTGCTAGGTCCTTTTCCCTAAATTTTTAATTCAGAAAATTAACCAGAATTGGCCAGATGCAGTGGTTCACGCCTATAATCCCAGCA
CTTTGGGAGTCCAAGGCAGATGGATCACTTGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACAGAGGAAGAAAGAGTGAAAACAAAAGAA
GAAAGAGGGAAACCCTGTCTTTACTAAAAATACAAAAATTAGTCGGGCGTGGTGGCGCACACCTGTAATTCCAGCTACTTGAGAGGCTGA
GGCAGGAGAATCCCTTGAAACTGCAGGCAGAGGTTGCAGTGAGCCAAGATTTCACTGCTGCACCTGGGGTGAGACTACCATTAAGGAAGG
AAATTTCCTTTAAACAGAAAAAAACAAAGGTGCTCATCTATTTCTTCTGAATTCTCTCTACATCCTTGACTTAAGAGGAAAACCAGCACT
CAAGAAACAGCTTTAAAAGAGAACAGTCCCCATTCTAGCTACCAGTCTTGCTTTCCCCCATCTTGGCAAGCCCCAGTGAATTTGCCATTG
AAAGATTACCCTCCCCTTTGCCCTCATCTGCCTGAGCTAGAGGCCAGGCTGTTGTTAATGTTTTTTCAGTTCCAAAGCCCCTGATGGGAC
ATTCTTGTTTCTGTGCTACTGCTTTCTCTCTCTTAAATTAAGGTGCAAGGGGATAAATATTACTATAACTGGGATGTAAGGCTCAGTCAG
TGTGGCTATTCCCTCCCTTCGGGGGAAATATTCCATCTGTCTGAACGGTTTTAGGTGATCATGAGGAGAGCGGCTTAGTCACACAGCCAG
CCACGCTCATCACAAAAGATTTGTTCAGACTCACTGTAAAGAATGACAAGGCAGATAGCTAATCCTTTCACTGTGCCTCAAAGCCCGCCG
TGCAAGTCACCAACCCTACCGGTCCTCTCCACGTGCGAGGCTAATAGAGTGATCAGAACCAGGAATGTGAGCTGGGTTCCACCTTAGGAG
GGGACAATGAGGACAGAGCAAGAGGGCTCCATGTTTAATTACTCCAGGCTCTGACTTCTGCCCACAATTACAGAGCATGAAAGCAGAATT
GGCCTTTAGTAAGTGAAAAGGAAGTGGCTCCTGCAGCATATAATTGTTATAATTTCGTATTTATGGAAAGAGAAAAGGACTTCAGTCCAC
TCATGTTGTTAAGCACTTGTCCCTCACTCCACTGGAGCCCCCTTCCTATGTTTTGGGCACAGATGGCTGGGACCGAGAGGAAAGAGGAAG
AGCGGCTGCCAGAGTGTGAATATACCCCTCAGGGATATACAGCGGAGTTTCATGATAAACTACCCATACTTTCCCAAAAAAGGTTGAGGA
GCAATACATAACTTTGCAGATTACAAACCCTTGTTTTACTTTTTAAACCTTTTTTCCATACTCTGCTTATTGGAAATCGATGGCTGTGAT
GTGACCAACACCTGTGATGATAGCAAAGCCCCTCCTTTCACAGTCTCCTGACTGTTCGGGGAACCTCCTTGGTCATTGGTAGAAAGCTTT
AGAAAAGACTTAGCTTTTTAGGGAAGAACTAAAAAATCTCCAAAACATACTAGTCCCATGACTTCGATAACTGAAAATGTCCTGGGTGTA
AACTAACCCAGGAATGTGGATCATACATGTTTTTTTTAAAAAAAATCCCTGAATCAATATTTTCCTACAACACACCCTAAAATTCCTATT
TTTGTAATTAATGGTTGGACAGTGATCAGCCATTTAAACATAGGCTTTCTGGAATAACCAGACACTAGAATAGTTTCCAAAGTGTTTTGC
GTATCAAAATCCTATATACTTAGAAGAAGAACTCAGGATAAGAAAAAATCGCTAGGTCCCAAAGGGTTCATGACTATCATCAGATGCAAC
TGCGAGTGGCCTACGGTCATTTTTTCAAATGAGAAGACTGGAGAGAGAGAACAACAGTAATCACAAAACCTCTGTTGCCCTTAGTCCATG
ACAATGTTTAAGGAAACTTTAAAAAATTAAGCCATCTTCTGAATTGTTTTCTACACCAAATCTAAAATATTAAAATGAAATTATTAAATA
TTTAAAATGGGGTATTTAGTGGAAATGCAATCAGTAGAAAACATTGCTTTTTAGTGCCTGCTAAACAAGTAAAGGAGAAAGAATGAAGAG
AAAACAGCAGTCCTTCCTGTGTGACACTCGTGTGGAAATGACAGGCATTCACATGTCATTGAGTGCTAACTCAAAAGCTAGGTGGCAATG
CTGTCCAATGTTTAGAGATCTTTTGAAATATAATTTTACCACCATTCAGAGGTAAGTACTTGCTTAACAGAAGTCTTTAATGTTAGTGAA
TGAATGTATAAAATTATAAACTATGCATTTTCAAAGAGTAGCATGTATTTTGTATCGAATCCAAGTAAATTTTTTTCATAGCTACCTACC
ACAACTGCAAATTATTCAAAATAAACTTGGATACATATCCTTATGGGGATATGGGAAGCCCATCTATATTCTCCTACTTGATGTTTTTAA
AGATTGAAACTTTATTCTGAAACATCAGGCTCTAAAAAATTCCATCATTAAGATGAATAAATGGGAAATGGTTTATTTGTTACTTCGTAA
GCATAAATGGGAAATGTTGGCTGTTAGAAAATGTGCCCAGTTCTTTAAAGGTGGATGTTCTAGTAACACTGGATTAACAAGCAAACAAAA
CTGCATGAAGTGAACGAATATTTCATTGGATAAAGTTAGCATAGGTTTTATCTGCTGGGTTTAATTCTCAATCCCAGAAAAAAATATTCT
TCAAGGGGTATCAGTTATAGTTTCAAAGAACAAAATATGAAAATATTGTCCAGCAAAGCAAATCATTGATCTTTTTTCAAAATTACTTAT
ATTTTGGAAAGTCTATATAGAATATCCACAAATTTCTTCAGCCCTCTTGTTGATTTCATATTTTCATGAAACTTTTTCCCCTAATAATTT
GTCTTCGCTCTTTAATCAGTGCTTTACTACATTACTCAGCCTGAAAAAATATCTTTTCCTTCATCTGACAATGTGGAAATAAAGAACTCC
ATTTCTGTCATTCTGGTTCTCTTCAGTGTCCATTGAGAAAGTTTCTCAACTGTTTGTAAAATACGGGGGGAAAAAAACACGCATTTCTAA
ACCTGGTACTTAAGGTTATACTGGATTGTTTGCTACCTAATTAGAAGTTATTGGGGAAGGGGCATTGTGTCTTTTTATATGATTTTTAGC
CAAATCCAGATGTTCTGATACACATTTCTGAATACCTGTCTGACTGTAAATACAGCCTGTGGAGGTTCAGGTTGATAAACCTTTCACCTG
ACTGCTCCACAGCCATGCTCCTTGCCAGCTTCTGGCACATTGTACATAGATTTGTTGAATGTTTAAATGATGTTGTTTTTCTAAATGCTG
TTCTCTAAAACAATTTTTTGAATTTCTTTTGCTTTCCATTGTTTTGGACTTTGTGTGTTCGTTTTTTAAAAAAAAAAATGTTTCCTAAAT
ATTTAACACCAGGAAAAATATTTTTAAATACACTGGTGCTAATTGAAACAGAAGGAAATTTTCAGATCGAAGATGTACAATGTTAAATGT
TCATACCAGTTAAACTGCACTTTCCCAAGGGGACAGCTGGCATCTACTTGAAATGGGCATCAAGAGACCACCAAATGTTTACAGTTTCTG
TGGCCCGTTTAAGTGTAAAATGCAGAAGTGGCTCTGTCCCCCCAGAGTTAAGGATTTGCTACACTGGTCCTCTGGAAGCATTTAAGTAGA
AGAAAAGGCTTATAGTCAGAATCACTTTAGTAATCGTCTTCTGGTCCTTGGACTTTTCTGTTCTGTAATGCTTGTAACAATGAATATGGT
GTTGCCAATCTAGTCTGATATCATTGTTGACCTGTACTTACTTTGTGGATGGTTCTACCTGGGGTTGCACTGGCACAAACAGAGCCAGAA
CACTGGACTTTCAAAAGACCATTTTGACTTCTACAGTGTCCACACACATGAATTTAAATGCACTTGTAACTGGTTAATTACCATGAAGTA

>49631_49631_1_LRBA-ZNF704_LRBA_chr4_151935578_ENST00000507224_ZNF704_chr8_81605342_ENST00000327835_length(amino acids)=343AA_BP=5
MSLTWKSSEELDMDKVTAAMVLTSLSTSPLVRSPPVRPNESLSGSWKEGGCVPSSTSSSGYWSWSAPSDQSNPSTPSPPLSADSFKPFRS
PAQPDDGIDEAEASNLLFDEPIPRKRKNSMKVMFKCLWKNCGKVLSTAAGIQKHIRTIHLGRVGDSDYSDGEEDFYYTEIKLNTDSVADG
LSSLAPVSPSQSLASPPTFPIPDSSRTETPCAKTETKLMTPLSRSAPTTLYLVHTDHAYQATPPVTIPGSAKFTPNGSSFSISWQSPPVT

--------------------------------------------------------------
>49631_49631_2_LRBA-ZNF704_LRBA_chr4_151935578_ENST00000510413_ZNF704_chr8_81605342_ENST00000327835_length(transcript)=14434nt_BP=501nt
ATCTCCGCCGCCACCTCGGTCTCGCTGCTCCTGGGCGGGGGGTGAGGACGAGTCCGGAGTATCTGGGGTTTGGCGTTGTTGTCAGCCTCG
GGGAGAGAGATTGGACAAATATTCTCCAAGAGGAGGAGGGCGACGCCAAGGACTTTCCACATCAACTGCTTTGGGGTATCTCCACAAGTT
GGAAGAGGGACCCTTTCGTTTTGCATTGCGTGTGTTGTGCTCATTACCAGTGCAGCGACTGCCGTCCCAGGGTGACTCTGAGTTGTCCTT
TATCGTGAGCTAGCAATGGCTAGCGAAGACAATCGTGTCCCTTCCCCGCCACCAACAGGTGATGACGGGGGAGGTGGAGGGAGAGAAGAA
ACCCCTACTGAAGGGGGTGCATTGTCTCTGAAACCAGGGCTCCCCATCAGGGGCATCAGAATGAAATTTGCCGTGTTGACCGGTTTGGTT
GAAGTTGGAGAAGTATCCAATAGGGATATTGTAGAAACTGTCTTTAACCTGGAAATCTTCAGAGGAACTAGACATGGACAAGGTGACAGC
AGCAATGGTACTAACCAGCTTGTCGACTAGCCCTTTGGTTCGAAGTCCTCCCGTGCGGCCGAACGAGAGCCTCAGCGGATCCTGGAAGGA
GGGCGGCTGCGTGCCTTCCAGCACCAGCAGCAGCGGCTACTGGAGCTGGAGCGCCCCCAGCGACCAGTCCAACCCGTCCACGCCGTCGCC
GCCGCTCTCGGCTGACAGCTTCAAGCCCTTCCGCAGCCCCGCGCAGCCAGACGACGGCATCGACGAGGCGGAGGCCAGCAACCTGCTCTT
CGACGAGCCCATTCCCAGGAAAAGAAAGAATTCCATGAAGGTGATGTTCAAATGCCTCTGGAAAAACTGTGGGAAGGTGCTGAGCACTGC
AGCAGGTATCCAGAAACACATCCGAACCATCCATCTGGGGCGCGTTGGAGACTCTGACTACAGTGATGGAGAAGAGGACTTTTACTACAC
TGAGATCAAGCTCAACACAGACTCAGTGGCAGACGGGCTGAGCAGCCTGGCCCCGGTCTCACCTTCCCAGTCCCTGGCTTCACCTCCTAC
TTTCCCCATCCCAGATTCAAGCCGAACAGAAACTCCTTGTGCCAAAACGGAGACTAAGTTGATGACGCCGTTGAGCCGCTCAGCTCCCAC
CACCCTCTACCTCGTGCACACTGACCATGCTTACCAGGCCACACCCCCTGTGACCATTCCAGGATCGGCCAAGTTCACCCCCAATGGCAG
CAGCTTCAGCATTTCCTGGCAATCTCCTCCGGTCACTTTCACAGGCATCCCAGTGTCACCCACACATCATCCGGTGGGCACAGGAGAGCA
GAGACAGCATGCGCACACGGTCCTGTCCTCCCCACCCAGAGGCACAGTCAGCTTAAGGAAGCCCAGGGGAGAGGGCAAAAAGTGTCGGAA
GGTGTACGGGATGGAGAACCGAGACATGTGGTGTACCGCCTGCCGCTGGAAGAAGGCCTGCCAGAGGTTCCTCGACTGAGAGACCCCCAG
GCAGAGGGGCTCAGGGCCCTGAGCCGCTCCTGCCCTGGCCTGCCACTGCAGGTGTTGGAAAGAGCTTTTCCTACTGAATAAAACACAGTT
GAAGCCAGGAAAAGCCCTTTCAGGAACCTTGGAGGAATAACAGCAAAAACACAGAAAAATTGTTTAAGTCACCACCTATGACAAAAGAAA
GTTGCTCTTACTGAGAACCCAGCTTGGAGCAGCTATAACTAGTTTTTTTTCCTTCAAAAGAAAAGTCAACTTTTTTTGCTGTATGTCTAG
ACTTAAAACTGTGGACTTCTGTAGCAATTGAACCAACAAAGCCCATTTTACCTAGAAAGGAGGCATATTTTGATAAGCTTTCTGAATTAT
GCCATTTTCAAGATTTTTTTGACACTTAAAAAACAAGCTACAGGTTATTCAGTAGCATTTGTACAAAGATCAATACTTACTTTTGTTGTG
AATAATCTTTTCCGTATCTTCCATTTGACTTCTTGGAGCAGTATATGTCAGGATGTGTTGCAAGACAGCGCAGCACTCTGGGCATCTTTT
CTATGGCTTTTTGTTTGTTTTTCTTTTAAGAATGGCCCCACACTGAACCATGGTAGAGCTATTAGTTTGTAGGGCCCCAGATGGCATAAA
CTCGAGAAGGGATTGTCCACGGAAATCACCAGCAGACTTCAGCCCGAAGCTGAGTTCAGGAAGTCCAGCTGTCACTGTTGGGAAACATCT
AGGAGTCTTCCTTGGATCCATAAGAAGCTCTTCCCCTAAAGGCAGCACAGCTAACTCTACTCTCTACCTGCCACAACTCAGTCAAGAATT
GGCACCTGTAGCCATCTGGGTAAGCCTCGATGCTTCTTTCAGGGATGTGACACAAATGGCAACTCGGAGCTATTTGTTACTGCTTGTCTG
TCAAGATTGTAGCCAGGTTAATGGGTCATTTTCCTTCTCTCCAGACTCCACCACTGACTGATTTCAGAAGAGGTAGAGAACTCCAAACTG
TCCCAGCAGGTTTGCTTTAGACAACAGAGCACAGCCCACATGGCCCTACCTGTTCAGAAAGTCATGTTAGATCAACAAACCACTTCCATT
CTGAGTGCACTTTTATAGGTTTTATGCTTTAGCATGTCCGGGAGATGAGTTAATTAACAATATAAACATTATGTGAGTAAATGGAAGGTC
CAAACTTTAAGTTTTTCTTATAAAAATATTGGAGCTATTCATTTAAGAATTTGCTCAAAAGGGAACATAACGCCAAAAGGAAAATGCATG
TAGGTATAGGAATTTCTCAGTTTAGTAGGGCCAGGGCTTGCACTATGTTCCATTTATTGGGCTTCGTAACTTACTTGCTTGTTTGTTTGG
GGGATAGTGGTGTGGGGAGAGGGGAGTCGTCAAGCCCTATAAATAAGCTCATTCTCTATCTACCCGACTCTCAATTGCCCTGCTAAAGAG
TTATTTCTCCTATACCTATGCAAAGTAGGAAGAGCACCTTATAGGAGGCACTGTATAGGGACAGGGGACATGGGATCAGCCATAGGAATG
TTAAATGAAATTGCACAGAGGAAAGTTTAATATATGTCTAGAGATTATACATACACTTTTTTAAGCGTAAAAAGAAGACATCTAGTAATG
ACAGATATTCTTTTTATATACAAGCAAAAGAAAGTATAAGGAGGTTCTACAGTGCAACATCCACAATCTGTGCATTCACATATTATGGGA
CTTTTATTTTTTAAACTCTCATATAAATTTTTTAAAATTACTCCTTGGAAGAGATCCTGGTTTTTTTCTTCATTTATTTTTTTCTTTAAA
AACATTTATTTTAAGAGAAGAGAAAAAGAGCTTCATCTAATTTTGCATCTTGATTACCAATCAGTACTAGTCACAGCACCAGCAATACTG
TATGTTTTAGACTGACAAGGTCAGCCAGGAAATGGCATTTTTTTAAACGCAGAAATGTGTTTGTTTCCTCTACTCTAACACGTCCTTTCT
CCTCCTGGTGTCCTGTCACCCCCCATGCAGCACCACTGATGCGAGATGATGCTCTGGCCTGGTCCAGGAAGCCCTGAGCCATGGGCAGAT
TGCCCAGTGGCCTTGGGCGGCCAGAGCTTGTCACCTGTTTAAACAAGTTCACCATGTGTTTAAATGACAGGGTACAGTCCTGGACCAGAG
GTTTTTCTCTTCAGCAAAGCTCCCTGGCCCTTGATCGTTGGACTGTTACTAATAGAAAAAGATTCAAGTCATGAAGTATAAAATCCATCC
CCCATCCCAGAACTTTGAAACACAAGGAGGGAGAGATCTTTGCTATGGAGCAGTCCTGGAGCAAAGCCCCGTGGCTTCCACCCCCAGATA
TATACCCCATAAGTAGTGCTGAGCTCCAGCTTAGCTGAGCCAAGCTCAGTCCTTATCTGGTGTTCAGCCAGTGCACAGGTATAAGCAGAA
CTACAGAGCTGAATGTAGCTTCCCTGGGATCTCTTCTCCTTTCTAAAGCATTTTTCACACAGTTCTGTACCTCCTACCCAAGTTGGGGCT
GCTTTCTGCCTGCTAGCCCACGGCTCTGTGTACTTTCTTTTCTGGCTTCAGGTGCAGACAGACCCTCAGTACCTTCCTGGACACAGACAC
ATATTCCCTGGACCAAGGCGTGGAATAACTAGTAGACCACCAAGCCACAGGTGGCTGGTCTTGAAGAAAAGGGATTATACTCCTTACAGG
CCACCCAGAAAGCTATGAATTCCAATATACACCACTGATCGTGCAAGTTAGGGTTTTTTTTTTTTAAACGTAGCATTATTTTGTTATATT
TTGGAACTAAATGAAGTGCCAAATTAACCAGACATTCGTTTGATGCCATCTCTGTGGAACCAAGTTCTCTGTGTGTGTTCGTTTGGCTGG
GAGGAGGGGGAGGACTGGGCAGACTGCTCCCACAGCAGGCTGGCAGTGGAACTGGAGCCCTGGCCACCGCAGGGAGCTCAGAGGCCAATC
TACGCAAAAGGCATGCAAAACAATGGATTCTGGTCCCAAAATATTTCTAAGTAAGGCATGATGTAGCCTTTTGATTTTTTTTTTATCCTT
TGACACCCCAGCCTTCAGAAAAGGTTTTTCATCTCTCTCCAAAGAAGTCATTTCATAGTGACTGACAGGACATTCTCCAGAGAGCGACAA
AGCAGAGTGGCCAGCAGGCAGTGGTGTTAAGCCTTGGGCCTTCCCAGCAGATGTGTGCTGCATTGGTGGGTGGGAGGCAGTGTGACAGCC
TGGAGAAAACACACAGGTAGCAAGGGAGTCAGGGGGGAGGTACAAGAGGGCTGTGGACACCTGGCTCTTGCTCATCTTCTTGGTGCTGAT
CAGCTGGTGGTCACCATCCCTAAGTACCTCCCAGGGAGCTGCCATTTTCTCCTCTGGGAGCAGCTGCCTGAAGCAAGGAGAGAATGACCT
GAAGGGAAGTACCTCCGGCCAAGAGTGCAGGGCTGCTGTGCCTAGCCTGAGCGGGCCATCTCTAGCAGATATGGACTTCTCTCCACCACA
CTAGCTGAAAAGTTTTCTCCCTTGGTTGGCAAAAGCCAGTGTCAGGAAAAAAGCTGTGGGTTTCTGACCAAGAATGTGTGCGCTTAGCTG
CAAAGTGCCTGTCAGCAGCTCCAGGCACCAACAAGGTGCCCTTTTATTAGACAATTCCTGCCCGAACATAACCATATTGCAGATGAAAAT
TTTCAATAGAGAATGACACAATTCTTGACCTTTCTAAAAACTTTTCAAAGAGATAGTCACATGTGTATATGTTGCAAAAGATTTTTGAAA
CTGAAATGTCCTCCATTAAATCTCAAGAGCACTCGAGTTTTAAGTCTGCTGTTTCTGGTGTCACACTAAGACACACTTTTGAAAGCAGCC
CTGGGTTCTGAATTAGTTGGCACTGCTGAATCCATGTTCCCCCTTCATCAGACTCCAAAGTGCAGCATTCACTTGCAAAGGTTGAGAGAA
AAGTGGCCAGAATTGTACATATAACAGAGAATACCTTGAGAATAGTAGCAAAATACTGTAAATAATATTCATTTCCTCAGGGAAAAATAA
AGGGCATGCAAAAATAGGTCTGGAGACTCCTGAAACTAGGAAGAATTTTGTTATCACTAAAGTCTTTTATAGTCAGAACAATTTTTTTTT
CAAATGAACATGGTATCATTTCAAGACAAATTTATGTGAACTGGGCAGTACTGACATTTGTGAGGCATAGGGGAGTGCCCTGGGAAAACG
GTTTGGAGCTGACCTGTAGCCTAAGGCTAACATTTGAACCACAGGTGCAATGCCTGGGGGTGGGGGAGGGGGACGGGGTGGGGGTGGTAT
TCCTAGACTCACGTAAGGCTTTTTCTGAATGTAATTGTGAATACAAAGCCTTGCTGGTCCTTTTTATCATTACCCAATGGATGACTGTTT
ATTAGCTATCAGCAGAATTCCGTAGGCGAAAGCAAGCCGTGAACGATGTACATTTTGCTTTAATAGCATGTTAGCGAACAAACTTCCATG
GACTTTTGTGGACAAGGTGCTGCTTTTTCTCATGACCCTGTAGAATTGCTATCGACCACATCTTCTGTAGCACTGACCTGTGTGAACTCA
GGGAAGAATTTGTGCATACAAATGAGTGGAAACAGAGCAGGATTCATGAATATGAATGAGAATGTGAATCATTTTGGAGAATGCCCTGGG
CACACGGGTCAACTGGAAATTTCATTTCTCTAAGAAAGTAGCCCTACCAGCGGCACGGACTGTTCCTGTTCCTCATACCTGTGGGGATTC
CTCCATATTGGAACTGTTTCATGTATCTTTTTTGCATTGTAACTAGCCAAACCTGAAGTCAGTAAATAAAATGAGATTAGCACTTTTTTT
AGGTACCAGTTGTATCACTGAGTAATGCACACCAATAGAGCAAGAAAGTATAAAATGTATTTAAGACCAACTGGTTTGCTTATTATGACT
GACTTTGAAAAAGCCCATATCCAATGATATACATGCTTTAAAAGGTATATCTATCGTAGGACCAGGAACCAAAATGGGAATTTTACTTCT
GGTCCTGTTTTGTAAATAGTTCCTTTTTTTGAAGACAATCTCATGTTTTATAACTTTTGTTGTGGGTCTGAGAATCACAATGGTAATATG
TCTTGGCAAAACATAACCTTTAAATACAAAAACAATTATAACTTAATTTTCCAAATAAAACAAGAAATACACTGATTAGGCTTCTACAGT
TCTAAGAGACATGACACTTTGGTAATAAGCGTCAGTACTCTACTTCTCAAGTTAACTGGAAATATTTTACAAGATGCAGTGTTTTGTAAT
CACAAAGAACGCAGACATTTTGTGAGAAATGACCTTGGTTTTATACATTGTAGCTTATTTTTTAAAATATAGTATTTTACCAGGCAGGAA
GTATTAATATTATAAGTAATTCTTGCTCACCAAACAAAGGGCTATGTCTCTTTTAAGCAAATGTTTTGATGCATATCTTTTTAATTAACC
CTCTGCAGCAAGGGTAGAAATACAGATCAGATGGAATGGGTATTATAGGAGAATCAAGATAGCAACAGCTACTCCTTTTACCATTACTAG
TGTGTTTTCAAAGTATGGAAAAAGATGCCTGAAGAGTCATTTTATATATTTTAAATCTAAAAAGTGTTAACAGGTATGCTTATAGGCCAT
GGGAGAAATATTCTTATAAATTTTTTAGTGTAAAATGATAAATTCTGTGTCACAAAGACAAGTTTACCACTTGACCTACCAGAATCACAG
ATACTTGCATTTAACTAGCAAGTATCATTTGGTGGAAATTTCTAAAATCATAGTAGACAGGCCCAAAGATAGAATTCTTAGGTGATCAGT
AGTGTTTAAAATAATTTTGTCCTCAGCACTAACTATATAACTGTAATTTCTACATAAGAACAAGTGCTTCCAAAATATAGTGGAGGGAAA
AAATAAAAAAGGAAAATAAAAAAACAAAACAAAAAGAACAAGTGCTTGATTTTTCACTGTGAAGAACTAGCAGGCACATGAGGTTGTGAT
CAGAAAGTGACTGAGTTCCCAAGAACCAGGAAACAGAGGGGAGTTGTGAAGAGTTTATTAAAACTGTACAAATAATTCAGAGCTTTGCCA
AAACCATTTCATAATGCTGTACAGTTTTTTCAAGCCCACTCACTGTTAAAACAAGAAAGCACCTTTTCTTTCTAAGATTTTAGTAATCCA
AAAGCTAGCCTAATTAGCCAAGTATGCAGATAACATCAAAAGCAAAGCTGAGATAGAACAGCCATACACCCGTTGGGCAGCTCTTATGAG
GTGGTCAGAAGGTCACTCAGACCTTGGTTTCAAATAGGCTTTAGAATCTGCACACTTGAGGACTAGAAATGCACAGAGTTAGGGAAAGCC
ATGTACAGGCTTGGCTCCTAGTCTTTGAGATGAGGCGTCTTGCAAATCTCTGTTTTCACTCCTTGGAATGTCTCCATTGTTAGCATTAAA
GTCCCCAAGAAGTTTTTATTGCTGTACGGTTTTGAACCCAATGAGTCTCATTTCCAAAAGATTCCTAATTCTATATAGGAGAGGTTGCAA
ATGTCAGTGCCTCAGAAGGACCAGGCAAGTTCTGTAAATGATTGATGTGGATAAGGCAAAGAGGAACACAAGAATGGTGGAGACCAGGTT
GAACTGCAGAACACATGCCCTCTTTGAAGGGGTGCCCACACTCAGCTCTAGACAATCAGAACCATGCAGAAATCAGGCCCAGGGCTGCTA
GATCTTCTGACGTGGAAGTATGATATTACCTGACACGTAAGTGTTGACAACTAACTCAAACTCTTGGCCAACACTGTGCAGACCAAAGAG
AAGCTGTACACAGACAGGTGCAGCCTGCAGCCCCCAGTTTCAACTATTGGGAAAAGTGGATTTCACATTCCACAGTTGTCAGGTCAGGTT
CATCCATCAGCCCCACAAACTCACATGTCGGCACTATCTGGGCAACTAAAATAAAAGAGGGGAAAGAGATCATTTCTCCCCAGATATCAT
TCTCATGGCAGACTTGAATATAGATACGCTGAGTTATCCAGCTCTCTCACTCTGCCTCCTTTTGGCATGCCCAGGCTGTGCCCCGTAAAG
TGTTGAATCACTGTTATCCTAATTTTCTTAGTGTTTTCTACCGTGGCCACTGTGATGAGGGGCTGGCAAAGAGCAGCCTCGTGCCTTCCG
AGAAGGCTGCCAGGAGCCTCTGAAGCTTGAAGCGAGCACACATTGCCTCCTTGTGCCAAAGCCCTTGGCCAGCCTCCCCACACTCCTTCC
CTCTCCATCCGGCCTCATGAGTCTTCGTTACCAAGTAAAATTACCACTGCTTCACCTCTGATACAGCAGAAGCCTTGCTTCAGAACTGGT
AGGCATTTAGGCTATTTCAGAGTGTCCACTAACCTCAAAAGGAGGTTTTTCCACATACAAAACCCTAGCATCTTTGAGGGGAAAGCAAAA
TGAGAATAAATTATGTCATGAAAAAAATTAGAAGTTGCTTCCTTCATTTAGATGGACTAAGTTATTTTAAACTCTATCTTACATCAGAGT
CCTGATGGTGTTGGGATAGTCACTGACCCTTTCACGTATGTAATAAGATACGTCTCGTTCACACACTATTTCATTTGATCTTTGTAAGAA
CCCAGTGTAGAATAGGAATATTTAAAATCAACATTACCCACCTCCAAGGCCAACCCAGAGTAGTCTTGAACCTGAGTCAGCCTCAGTATT
GCTTGCAAGGAAGAGGGAAGGGGCTCATTAAAGGCCTGGCTCAAACCTTAGTCTTCCAGACTGACTAGGGACGTAAGAAGACCCAGGGAC
CCACCATGTTCTCAAACCATCTATTCAGTCCAGGCCTTTCAGCATAGACATAAAGAGCCCACCCGTTACTCAGTCATGTTGCCAAGTGCA
AACTGATTTATCCCCAGATGAATCCCTTTACTGTAGCAGATCCCTAATCCCTAAATTTCAGCCAATTTGGTAGTTAATTATAGGAGTTTA
TTAGCTAAATGTATGTTCTGAGTAAAAGTTTTGACTCTTTGGGGAAAATTTATTTTGCTGCTAGCATACAACATTTGCTATGTATATAAA
CTTAAGTCAATGCCAGAAATTTTAAAACCAGCTCAAATTTATAATCTGTAATGATCAAATCAAAACATACTGTAAACTCAGAGTTGGAAA
CGCCTGGTAATATGGTTAAGTCATGTTTAAATATGAATGCAATTTAAATGACATTGGCAATGCCTGAGATTTCTTTCATTGTGAATGATT
AAAAGGCAGTCCAATATATGAATGGATTTCATCTTACCTTTCTCCCGTTAATTTACTAGGTGTAACATCTTGAGTGTAAAGTCATTCACA
GGCAGTTGGGTTGTGGAGCTAGAAGGAGCCTCAAAAAAAAACTTTTTGGCCAGACTCCTACATCATGAACAGGGTTTTTGATGAATAATA
TTTATTATTATGTTTCTAAAGTAATACAGTGTTGGAGAATGAAACAGTTTAGTCCTTTCCTCTTCTGATGGAAAAGAATCATAGCGCCGT
TGCCATGACAATAACAGGATGTAGAAAGACCCATGAAGAAAGAAAGAAGAAAGCTATGGTTCCGAAAGCAGGTAACCACAGATTTTGAAA
GGAGGCAGAGATGGTGATTAAACTGTAGTCCTTGTTTTTTAAAATGTTCTTTCATGTTAGGCACCACCACATAGTTAATAACTACCAACT
TCTAAAGAGAAGATCCCCTTGATTTATTTATATCATGAAAATACTAAAAATCAATTCTCAAGTCTAATTAACTATTACATTATCTTGCTA
GGTCCTTTTCCCTAAATTTTTAATTCAGAAAATTAACCAGAATTGGCCAGATGCAGTGGTTCACGCCTATAATCCCAGCACTTTGGGAGT
CCAAGGCAGATGGATCACTTGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACAGAGGAAGAAAGAGTGAAAACAAAAGAAGAAAGAGGGA
AACCCTGTCTTTACTAAAAATACAAAAATTAGTCGGGCGTGGTGGCGCACACCTGTAATTCCAGCTACTTGAGAGGCTGAGGCAGGAGAA
TCCCTTGAAACTGCAGGCAGAGGTTGCAGTGAGCCAAGATTTCACTGCTGCACCTGGGGTGAGACTACCATTAAGGAAGGAAATTTCCTT
TAAACAGAAAAAAACAAAGGTGCTCATCTATTTCTTCTGAATTCTCTCTACATCCTTGACTTAAGAGGAAAACCAGCACTCAAGAAACAG
CTTTAAAAGAGAACAGTCCCCATTCTAGCTACCAGTCTTGCTTTCCCCCATCTTGGCAAGCCCCAGTGAATTTGCCATTGAAAGATTACC
CTCCCCTTTGCCCTCATCTGCCTGAGCTAGAGGCCAGGCTGTTGTTAATGTTTTTTCAGTTCCAAAGCCCCTGATGGGACATTCTTGTTT
CTGTGCTACTGCTTTCTCTCTCTTAAATTAAGGTGCAAGGGGATAAATATTACTATAACTGGGATGTAAGGCTCAGTCAGTGTGGCTATT
CCCTCCCTTCGGGGGAAATATTCCATCTGTCTGAACGGTTTTAGGTGATCATGAGGAGAGCGGCTTAGTCACACAGCCAGCCACGCTCAT
CACAAAAGATTTGTTCAGACTCACTGTAAAGAATGACAAGGCAGATAGCTAATCCTTTCACTGTGCCTCAAAGCCCGCCGTGCAAGTCAC
CAACCCTACCGGTCCTCTCCACGTGCGAGGCTAATAGAGTGATCAGAACCAGGAATGTGAGCTGGGTTCCACCTTAGGAGGGGACAATGA
GGACAGAGCAAGAGGGCTCCATGTTTAATTACTCCAGGCTCTGACTTCTGCCCACAATTACAGAGCATGAAAGCAGAATTGGCCTTTAGT
AAGTGAAAAGGAAGTGGCTCCTGCAGCATATAATTGTTATAATTTCGTATTTATGGAAAGAGAAAAGGACTTCAGTCCACTCATGTTGTT
AAGCACTTGTCCCTCACTCCACTGGAGCCCCCTTCCTATGTTTTGGGCACAGATGGCTGGGACCGAGAGGAAAGAGGAAGAGCGGCTGCC
AGAGTGTGAATATACCCCTCAGGGATATACAGCGGAGTTTCATGATAAACTACCCATACTTTCCCAAAAAAGGTTGAGGAGCAATACATA
ACTTTGCAGATTACAAACCCTTGTTTTACTTTTTAAACCTTTTTTCCATACTCTGCTTATTGGAAATCGATGGCTGTGATGTGACCAACA
CCTGTGATGATAGCAAAGCCCCTCCTTTCACAGTCTCCTGACTGTTCGGGGAACCTCCTTGGTCATTGGTAGAAAGCTTTAGAAAAGACT
TAGCTTTTTAGGGAAGAACTAAAAAATCTCCAAAACATACTAGTCCCATGACTTCGATAACTGAAAATGTCCTGGGTGTAAACTAACCCA
GGAATGTGGATCATACATGTTTTTTTTAAAAAAAATCCCTGAATCAATATTTTCCTACAACACACCCTAAAATTCCTATTTTTGTAATTA
ATGGTTGGACAGTGATCAGCCATTTAAACATAGGCTTTCTGGAATAACCAGACACTAGAATAGTTTCCAAAGTGTTTTGCGTATCAAAAT
CCTATATACTTAGAAGAAGAACTCAGGATAAGAAAAAATCGCTAGGTCCCAAAGGGTTCATGACTATCATCAGATGCAACTGCGAGTGGC
CTACGGTCATTTTTTCAAATGAGAAGACTGGAGAGAGAGAACAACAGTAATCACAAAACCTCTGTTGCCCTTAGTCCATGACAATGTTTA
AGGAAACTTTAAAAAATTAAGCCATCTTCTGAATTGTTTTCTACACCAAATCTAAAATATTAAAATGAAATTATTAAATATTTAAAATGG
GGTATTTAGTGGAAATGCAATCAGTAGAAAACATTGCTTTTTAGTGCCTGCTAAACAAGTAAAGGAGAAAGAATGAAGAGAAAACAGCAG
TCCTTCCTGTGTGACACTCGTGTGGAAATGACAGGCATTCACATGTCATTGAGTGCTAACTCAAAAGCTAGGTGGCAATGCTGTCCAATG
TTTAGAGATCTTTTGAAATATAATTTTACCACCATTCAGAGGTAAGTACTTGCTTAACAGAAGTCTTTAATGTTAGTGAATGAATGTATA
AAATTATAAACTATGCATTTTCAAAGAGTAGCATGTATTTTGTATCGAATCCAAGTAAATTTTTTTCATAGCTACCTACCACAACTGCAA
ATTATTCAAAATAAACTTGGATACATATCCTTATGGGGATATGGGAAGCCCATCTATATTCTCCTACTTGATGTTTTTAAAGATTGAAAC
TTTATTCTGAAACATCAGGCTCTAAAAAATTCCATCATTAAGATGAATAAATGGGAAATGGTTTATTTGTTACTTCGTAAGCATAAATGG
GAAATGTTGGCTGTTAGAAAATGTGCCCAGTTCTTTAAAGGTGGATGTTCTAGTAACACTGGATTAACAAGCAAACAAAACTGCATGAAG
TGAACGAATATTTCATTGGATAAAGTTAGCATAGGTTTTATCTGCTGGGTTTAATTCTCAATCCCAGAAAAAAATATTCTTCAAGGGGTA
TCAGTTATAGTTTCAAAGAACAAAATATGAAAATATTGTCCAGCAAAGCAAATCATTGATCTTTTTTCAAAATTACTTATATTTTGGAAA
GTCTATATAGAATATCCACAAATTTCTTCAGCCCTCTTGTTGATTTCATATTTTCATGAAACTTTTTCCCCTAATAATTTGTCTTCGCTC
TTTAATCAGTGCTTTACTACATTACTCAGCCTGAAAAAATATCTTTTCCTTCATCTGACAATGTGGAAATAAAGAACTCCATTTCTGTCA
TTCTGGTTCTCTTCAGTGTCCATTGAGAAAGTTTCTCAACTGTTTGTAAAATACGGGGGGAAAAAAACACGCATTTCTAAACCTGGTACT
TAAGGTTATACTGGATTGTTTGCTACCTAATTAGAAGTTATTGGGGAAGGGGCATTGTGTCTTTTTATATGATTTTTAGCCAAATCCAGA
TGTTCTGATACACATTTCTGAATACCTGTCTGACTGTAAATACAGCCTGTGGAGGTTCAGGTTGATAAACCTTTCACCTGACTGCTCCAC
AGCCATGCTCCTTGCCAGCTTCTGGCACATTGTACATAGATTTGTTGAATGTTTAAATGATGTTGTTTTTCTAAATGCTGTTCTCTAAAA
CAATTTTTTGAATTTCTTTTGCTTTCCATTGTTTTGGACTTTGTGTGTTCGTTTTTTAAAAAAAAAAATGTTTCCTAAATATTTAACACC
AGGAAAAATATTTTTAAATACACTGGTGCTAATTGAAACAGAAGGAAATTTTCAGATCGAAGATGTACAATGTTAAATGTTCATACCAGT
TAAACTGCACTTTCCCAAGGGGACAGCTGGCATCTACTTGAAATGGGCATCAAGAGACCACCAAATGTTTACAGTTTCTGTGGCCCGTTT
AAGTGTAAAATGCAGAAGTGGCTCTGTCCCCCCAGAGTTAAGGATTTGCTACACTGGTCCTCTGGAAGCATTTAAGTAGAAGAAAAGGCT
TATAGTCAGAATCACTTTAGTAATCGTCTTCTGGTCCTTGGACTTTTCTGTTCTGTAATGCTTGTAACAATGAATATGGTGTTGCCAATC
TAGTCTGATATCATTGTTGACCTGTACTTACTTTGTGGATGGTTCTACCTGGGGTTGCACTGGCACAAACAGAGCCAGAACACTGGACTT
TCAAAAGACCATTTTGACTTCTACAGTGTCCACACACATGAATTTAAATGCACTTGTAACTGGTTAATTACCATGAAGTAAGTCTAACTT

>49631_49631_2_LRBA-ZNF704_LRBA_chr4_151935578_ENST00000510413_ZNF704_chr8_81605342_ENST00000327835_length(amino acids)=343AA_BP=5
MSLTWKSSEELDMDKVTAAMVLTSLSTSPLVRSPPVRPNESLSGSWKEGGCVPSSTSSSGYWSWSAPSDQSNPSTPSPPLSADSFKPFRS
PAQPDDGIDEAEASNLLFDEPIPRKRKNSMKVMFKCLWKNCGKVLSTAAGIQKHIRTIHLGRVGDSDYSDGEEDFYYTEIKLNTDSVADG
LSSLAPVSPSQSLASPPTFPIPDSSRTETPCAKTETKLMTPLSRSAPTTLYLVHTDHAYQATPPVTIPGSAKFTPNGSSFSISWQSPPVT

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Fusion Gene PPI Analysis for LRBA-ZNF704


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRBA-ZNF704


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRBA-ZNF704


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource