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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRCH1-ATP13A3 (FusionGDB2 ID:49633)

Fusion Gene Summary for LRCH1-ATP13A3

check button Fusion gene summary
Fusion gene informationFusion gene name: LRCH1-ATP13A3
Fusion gene ID: 49633
HgeneTgene
Gene symbol

LRCH1

ATP13A3

Gene ID

23143

79572

Gene nameleucine rich repeats and calponin homology domain containing 1ATPase 13A3
SynonymsCHDC1|NP81AFURS1
Cytomap

13q14.13-q14.2

3q29

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat and calponin homology domain-containing protein 1leucine-rich repeats and calponin homology (CH) domain containing 1neuronal protein 81probable cation-transporting ATPase 13A3ATPase family homolog up-regulated in senescence cells 1ATPase type 13A3
Modification date2020031320200313
UniProtAcc

Q9Y2L9

Q9H7F0

Ensembl transtripts involved in fusion geneENST00000311191, ENST00000389797, 
ENST00000389798, 
ENST00000439040, 
ENST00000256031, 
Fusion gene scores* DoF score12 X 7 X 5=4207 X 9 X 5=315
# samples 1311
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/315*10)=-1.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRCH1 [Title/Abstract] AND ATP13A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRCH1(47127838)-ATP13A3(194126845), # samples:1
Anticipated loss of major functional domain due to fusion event.LRCH1-ATP13A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LRCH1-ATP13A3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LRCH1-ATP13A3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRCH1

GO:0034260

negative regulation of GTPase activity

28028151


check buttonFusion gene breakpoints across LRCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP13A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer173NLRCH1chr13

47127838

+ATP13A3chr3

194126845

-


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Fusion Gene ORF analysis for LRCH1-ATP13A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000311191ENST00000439040LRCH1chr13

47127838

+ATP13A3chr3

194126845

-
Frame-shiftENST00000389797ENST00000439040LRCH1chr13

47127838

+ATP13A3chr3

194126845

-
Frame-shiftENST00000389798ENST00000439040LRCH1chr13

47127838

+ATP13A3chr3

194126845

-
In-frameENST00000311191ENST00000256031LRCH1chr13

47127838

+ATP13A3chr3

194126845

-
In-frameENST00000389797ENST00000256031LRCH1chr13

47127838

+ATP13A3chr3

194126845

-
In-frameENST00000389798ENST00000256031LRCH1chr13

47127838

+ATP13A3chr3

194126845

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000311191LRCH1chr1347127838+ENST00000256031ATP13A3chr3194126845-397353661534193
ENST00000389798LRCH1chr1347127838+ENST00000256031ATP13A3chr3194126845-39415045832193
ENST00000389797LRCH1chr1347127838+ENST00000256031ATP13A3chr3194126845-38814445232174

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311191ENST00000256031LRCH1chr1347127838+ATP13A3chr3194126845-0.61424940.38575056
ENST00000389798ENST00000256031LRCH1chr1347127838+ATP13A3chr3194126845-0.610213460.38978657
ENST00000389797ENST00000256031LRCH1chr1347127838+ATP13A3chr3194126845-0.60887850.39112148

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Fusion Genomic Features for LRCH1-ATP13A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRCH1-ATP13A3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:47127838/chr3:194126845)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRCH1

Q9Y2L9

ATP13A3

Q9H7F0

FUNCTION: Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+11921_36102697.0Compositional biasNote=His-rich
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+11937_54102697.0Compositional biasNote=Gly-rich
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+12021_36102764.0Compositional biasNote=His-rich
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+12037_54102764.0Compositional biasNote=Gly-rich
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+11921_36102729.0Compositional biasNote=His-rich
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+11937_54102729.0Compositional biasNote=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119576_692102697.0DomainCalponin-homology (CH)
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120576_692102764.0DomainCalponin-homology (CH)
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119576_692102729.0DomainCalponin-homology (CH)
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119121_143102697.0RepeatNote=LRR 2
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119144_166102697.0RepeatNote=LRR 3
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119167_187102697.0RepeatNote=LRR 4
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119189_210102697.0RepeatNote=LRR 5
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119212_234102697.0RepeatNote=LRR 6
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119235_255102697.0RepeatNote=LRR 7
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119257_278102697.0RepeatNote=LRR 8
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+119283_304102697.0RepeatNote=LRR 9
HgeneLRCH1chr13:47127838chr3:194126845ENST00000311191+11998_119102697.0RepeatNote=LRR 1
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120121_143102764.0RepeatNote=LRR 2
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120144_166102764.0RepeatNote=LRR 3
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120167_187102764.0RepeatNote=LRR 4
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120189_210102764.0RepeatNote=LRR 5
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120212_234102764.0RepeatNote=LRR 6
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120235_255102764.0RepeatNote=LRR 7
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120257_278102764.0RepeatNote=LRR 8
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+120283_304102764.0RepeatNote=LRR 9
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389797+12098_119102764.0RepeatNote=LRR 1
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119121_143102729.0RepeatNote=LRR 2
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119144_166102729.0RepeatNote=LRR 3
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119167_187102729.0RepeatNote=LRR 4
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119189_210102729.0RepeatNote=LRR 5
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119212_234102729.0RepeatNote=LRR 6
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119235_255102729.0RepeatNote=LRR 7
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119257_278102729.0RepeatNote=LRR 8
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+119283_304102729.0RepeatNote=LRR 9
HgeneLRCH1chr13:47127838chr3:194126845ENST00000389798+11998_119102729.0RepeatNote=LRR 1
TgeneATP13A3chr13:47127838chr3:194126845ENST000002560313032231_23411611227.0Compositional biasNote=Poly-Tyr
TgeneATP13A3chr13:47127838chr3:194126845ENST000004390403133231_23411611227.0Compositional biasNote=Poly-Tyr
TgeneATP13A3chr13:47127838chr3:194126845ENST0000025603130321000_102011611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST0000025603130321074_109411611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST0000025603130321106_112611611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST0000025603130321144_116411611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000002560313032206_22611611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000002560313032233_25311611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST00000256031303229_4911611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000002560313032410_43011611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000002560313032449_46911611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000002560313032941_96111611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000002560313032963_98311611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST0000043904031331000_102011611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST0000043904031331074_109411611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST0000043904031331106_112611611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST0000043904031331144_116411611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000004390403133206_22611611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000004390403133233_25311611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST00000439040313329_4911611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000004390403133410_43011611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000004390403133449_46911611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000004390403133941_96111611227.0TransmembraneHelical
TgeneATP13A3chr13:47127838chr3:194126845ENST000004390403133963_98311611227.0TransmembraneHelical


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Fusion Gene Sequence for LRCH1-ATP13A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49633_49633_1_LRCH1-ATP13A3_LRCH1_chr13_47127838_ENST00000311191_ATP13A3_chr3_194126845_ENST00000256031_length(transcript)=3973nt_BP=536nt
CCGCAGTCCTTAGCTTCCCGGGGACAGGAAACCTTCAAGACCGAGCTGCCACGGCCGCCTCCCCGCCCGCCCCCCATTCTACGCGCCTGC
CCACACCCTCCTCCCCTCCTTCCAGCGCCTTTCGGTGGAGCACTGCGGCACTCAGCCCGAGCTGCCGTTTTCCCCTCGCGGGGAACGCTG
TGACCCCCCCGCAGGAGCGGCGGGGCGGGGTGGGGGGGCCCGGGAGAAGATGGCGACGCCGGGAAGCGAACCCCAACCTTTCGTCCCGGC
CCTTTCGGTAGCTACTCTGCACCCACTTCATCATCCCCACCACCACCACCACCACCATCAGCACCACGGAGGAACCGGCGCCCCCGGCGG
GGCGGGTGGTGGCGGCGGTGGCAGCGGGGGCTTCAACCTGCCCTTGAACCGGGGTCTGGAGCGCGCGCTTGAGGAGGCGGCCAACTCCGG
GGGGCTGAACCTGAGCGCCAGGAAATTGAAGGAATTTCCCCGTACCGCAGCCCCCGGGCACGACCTCTCGGACACGGTGCAGGCAGGAGT
CAGTGGATCGGTGGGGAAAATGCTGCTTACCCTGGGCCCTGGGCTGTAGAAAGAAGACACCAAAGGCAAAGTACATGTATCTGGCGCAGG
AGCTCTTGGTTGATCCAGAATGGCCACCAAAACCTCAGACAACCACAGAAGCTAAAGCTTTAGTTAAGGAGAATGGATCATGTCAAATCA
TCACCATAACATAGCAGTGAATCAGTCTCAGTGGTATTGCTGATAGCAGTATTCAGGAATATGTGATTTTAGGAGTTTCTGATCCTGTGT
GTCAGAATGGCACTAGTTCAGTTTATGTCCCTTCTGATATAGTAGCTTATTTGACAGCTTTGCTCTTCCTTAAAATAAAAACAGAAAAAT
ATATCGTCCTAACAGTTAAATTAACAATCAATCCATAAAGTCCTATATCTTCATTCAGCAACCCAAATATTACATACATTTCCAGAATTT
TCTTGATTGTTACTTTCAGTGATATTCTTTATATTGGGTACAGGAGAAGTTTGGTGTTTGGTAGGTTTTTCAACATTAGTTTTTGAGACT
AGTTTACCTCTTCACATTTATGCTCACAACCCTCTTGTTAGAAAAGTCTGTGTTTATATACAGGCTGTAAGTTTGTGATTGATAAAAAGA
AGATGAGTGTTAATTAGCCTCCAGTGAAAATATACTGAAAGCCTGTTTTCATTTGATTCCAATGTTTCTTCCAAAGAATTCTGTATAAAC
ATATGCCAATTCCCTATGATGGTCTAGAGTTAGGAATGAGTGTTTATGGTGTTGCTTATAGAACAACTCAGGTAATCTCCATTTCTGGTT
TTATATTTTCTGTACAAACTGCCTGGGTTTTATTTTTCTAATCAGCAAGGTGCTTCACTGCCTTCTTGAGACGCCTCTCAAAGCTCTTAA
ATGGCTCCTGTGCTATGTGTGGTGTTGGCAGTCTAATTTGCTTCTGTTAAATGTTGTAGAACCTTTTTCACTAGGAAATAAGATTCATTT
CTTTCGGCAGTAGATGTAGATTCATCTTTTAACGTTTCTTCAAATTTGTTTCTGTCAGGCTTTGTGTTATTTTAAATGGTTTTTTAAAAT
TTTCTTCTATGTTTTCAATTACCTAAAGACATAGGATAATAGTTTTTTTTAAGTTAGAATTTTACCTCATAAAATTTTTTGAGGTTTGAT
GTATGTCTCTGTCTTATCAATAATGAGGCTTAAAAAATACTGGATTTGAATGGCTGCCGTTTTTTCAAAGCAATATGAATTTGATGAGTT
TGTTTTATGCCATTAGGTGGCGCCAGAGGTCAGAACATGTCTATTTTGAATTGGATCGTTACAAATGAGCATATTTGATGCGGAAATTTC
TGGGAGAAAAAAAATTGAGGAAATAAAGTTAAAAAATTGACATTCATTGAGCCAAAAGAGATGTGGAGAAACATTTTTCACCTTTCTGTT
TGGCCTGATTAACATTTAAATTCTTGCCAAAATTAAGGTAACTTTTAAAAAACACCTTTTATAGGTGGATCCAGCAGTCTGGCAACGCCC
ACAGTTACCACAACACAGAAAACTGATCGTGCTATAAAATGGACGCTAAACTATGAAAACAGTGTGACATTGTTCTCTGTTCTTCCAGAG
CCAGTAACATGCTTGCTCGTGCTTTCTACTTCTAGCTGATCATTCTTTTCCCAACATATATTTACAAATTTACCAAATTTTACCTAGAAT
TTTAGGACCAAATGGTTCTCACTCTTTATGCTGCAAAGACCTGGATGATGTTTGGTAACTATAGAAAAATAGAAATTACACTCAGGATCA
CTGTTACTGCTATTGCCACTGATGATTCCTGCAAAAATATAATCGAAGTTTTCCATCAAATGTATAATATGCTATTAATACACATTAGAT
GATAACAGTTGTTCCATGAATGATTCTATGAAGCTATGCATCTTAGACCTCTTGAGCTGTGAATTAGCACTATTTTCTATAGTTACTTAT
TCTCTGGATCATTTTATAATTTCCATATTAATTTCAAATATGCTCGTGTTATTCTTCAGTGATTTCCACAATTGTGCATTTTATTCTTTG
GTTTAAGTACTGAAGCATATAATGAAAGTAATTGCTAAGTAGCAGCTTAAAAATTCAATTATCCGATTGTATTTAACATCTTTAAGAGCA
TGATCATAAAGAGCTATTTTTGACACCCCCCCCCCACTTTTTTAACATTTAGAGTTAGTAAGGGTTTTATATCTCTTCTGTCCATATTGT
TTTCAAAGGAATGAGGTGTTTAGGTGGCTGGAAAAGCATTTGTAGGAAGTTAGATTTGAATATAGACAAGGTGGGTTATTCACGTTGAGA
ATGTTATTTGAAGAATGCCTGTGAAGCCAGGTGTGGGTTCTACTCAGTGCCATAGATAGACTGAGTCTTCTCTCGTAGGTTACCATTACA
TAGTAATTTTGATTCTGAATTTCACATTAAATTATTTGAGTTTATACAGACCTAAATTTTAAAATCTGTACATATATTATTTTGATGTAT
TAAGATGAATATTGCTGATTTAAATTTTATTTATGCACATACTTAAAGGACAGAAATGTCTGGGAAAGTAATTGTTAAATAATGATATGT
AACTTTTTAACTTTTTAAATAAATAACAAGATTTTTAATGTGTGTCTCCCTCAGGGTTGTTTAAAGTTTTTTTTCTCCCTCAAGTATAAA
TAGTGGTAACTATATGTTTTGTATCTTCTAGCACCAACTGCTGTAAAGCAATGCTGCAAATAATGCTTGAATACAAGTGGCTAAGCCAAC
AACAGAATAAATACTTTTATAGTAGTTTTATAATCCTGAAATTCGAAAGCTTTCCCAATTGCACTTGCATCTAAACAAAACTGTTGCAGT
TTTTACTCTATTTATTTTGTTCCCCATGTTTATGAAAGTCCTGCACAGTTTCAAAGGCATGGTAAATAATATATCAATGTTTATGTAGTC
TGTTACAGAAACAGCTATAGATAACATTATCCAGTGAAGAGCAAAATTCAAGCTTTAGAAAATATTCATGCATGCAATTTTGACATATCT
AAAAATAGGTTTTTGTATATTTATGGTGGGAGGTGGTTGGGAACTTTTAACAAAATGGGGTGTTAATTTTTGTACAGTCTGTGGGCATTT
ACACATTTTTAATGTATTAAAATTTGGTAATTATGTGTACATTAAATTAATAAAAGTTACTTCTAGTTATGATTTGTGAATTCCCTAAGA
CCTTGGATTTTTTTAAGTAACTTTATATCAGAAATGATACTGCATCTTTATATTTTTAAAATTGTATTGCTGCTCAAGAATGGTACCCTC
TTGTCAAAAAGGCATACATTCATAATTGTACATTCAGCATTGTAAATAATCTTATGAAACCTTTTTTGATTGAAGCTATTCAAAATAAAA

>49633_49633_1_LRCH1-ATP13A3_LRCH1_chr13_47127838_ENST00000311191_ATP13A3_chr3_194126845_ENST00000256031_length(amino acids)=193AA_BP=0
MYFAFGVFFLQPRAQGKQHFPHRSTDSCLHRVREVVPGGCGTGKFLQFPGAQVQPPGVGRLLKRALQTPVQGQVEAPAATAATTRPAGGA
GSSVVLMVVVVVVGMMKWVQSSYRKGRDERLGFASRRRHLLPGPPTPPRRSCGGVTAFPARGKRQLGLSAAVLHRKALEGGEEGVGRRVE

--------------------------------------------------------------
>49633_49633_2_LRCH1-ATP13A3_LRCH1_chr13_47127838_ENST00000389797_ATP13A3_chr3_194126845_ENST00000256031_length(transcript)=3881nt_BP=444nt
ACACCCTCCTCCCCTCCTTCCAGCGCCTTTCGGTGGAGCACTGCGGCACTCAGCCCGAGCTGCCGTTTTCCCCTCGCGGGGAACGCTGTG
ACCCCCCCGCAGGAGCGGCGGGGCGGGGTGGGGGGGCCCGGGAGAAGATGGCGACGCCGGGAAGCGAACCCCAACCTTTCGTCCCGGCCC
TTTCGGTAGCTACTCTGCACCCACTTCATCATCCCCACCACCACCACCACCACCATCAGCACCACGGAGGAACCGGCGCCCCCGGCGGGG
CGGGTGGTGGCGGCGGTGGCAGCGGGGGCTTCAACCTGCCCTTGAACCGGGGTCTGGAGCGCGCGCTTGAGGAGGCGGCCAACTCCGGGG
GGCTGAACCTGAGCGCCAGGAAATTGAAGGAATTTCCCCGTACCGCAGCCCCCGGGCACGACCTCTCGGACACGGTGCAGGCAGGAGTCA
GTGGATCGGTGGGGAAAATGCTGCTTACCCTGGGCCCTGGGCTGTAGAAAGAAGACACCAAAGGCAAAGTACATGTATCTGGCGCAGGAG
CTCTTGGTTGATCCAGAATGGCCACCAAAACCTCAGACAACCACAGAAGCTAAAGCTTTAGTTAAGGAGAATGGATCATGTCAAATCATC
ACCATAACATAGCAGTGAATCAGTCTCAGTGGTATTGCTGATAGCAGTATTCAGGAATATGTGATTTTAGGAGTTTCTGATCCTGTGTGT
CAGAATGGCACTAGTTCAGTTTATGTCCCTTCTGATATAGTAGCTTATTTGACAGCTTTGCTCTTCCTTAAAATAAAAACAGAAAAATAT
ATCGTCCTAACAGTTAAATTAACAATCAATCCATAAAGTCCTATATCTTCATTCAGCAACCCAAATATTACATACATTTCCAGAATTTTC
TTGATTGTTACTTTCAGTGATATTCTTTATATTGGGTACAGGAGAAGTTTGGTGTTTGGTAGGTTTTTCAACATTAGTTTTTGAGACTAG
TTTACCTCTTCACATTTATGCTCACAACCCTCTTGTTAGAAAAGTCTGTGTTTATATACAGGCTGTAAGTTTGTGATTGATAAAAAGAAG
ATGAGTGTTAATTAGCCTCCAGTGAAAATATACTGAAAGCCTGTTTTCATTTGATTCCAATGTTTCTTCCAAAGAATTCTGTATAAACAT
ATGCCAATTCCCTATGATGGTCTAGAGTTAGGAATGAGTGTTTATGGTGTTGCTTATAGAACAACTCAGGTAATCTCCATTTCTGGTTTT
ATATTTTCTGTACAAACTGCCTGGGTTTTATTTTTCTAATCAGCAAGGTGCTTCACTGCCTTCTTGAGACGCCTCTCAAAGCTCTTAAAT
GGCTCCTGTGCTATGTGTGGTGTTGGCAGTCTAATTTGCTTCTGTTAAATGTTGTAGAACCTTTTTCACTAGGAAATAAGATTCATTTCT
TTCGGCAGTAGATGTAGATTCATCTTTTAACGTTTCTTCAAATTTGTTTCTGTCAGGCTTTGTGTTATTTTAAATGGTTTTTTAAAATTT
TCTTCTATGTTTTCAATTACCTAAAGACATAGGATAATAGTTTTTTTTAAGTTAGAATTTTACCTCATAAAATTTTTTGAGGTTTGATGT
ATGTCTCTGTCTTATCAATAATGAGGCTTAAAAAATACTGGATTTGAATGGCTGCCGTTTTTTCAAAGCAATATGAATTTGATGAGTTTG
TTTTATGCCATTAGGTGGCGCCAGAGGTCAGAACATGTCTATTTTGAATTGGATCGTTACAAATGAGCATATTTGATGCGGAAATTTCTG
GGAGAAAAAAAATTGAGGAAATAAAGTTAAAAAATTGACATTCATTGAGCCAAAAGAGATGTGGAGAAACATTTTTCACCTTTCTGTTTG
GCCTGATTAACATTTAAATTCTTGCCAAAATTAAGGTAACTTTTAAAAAACACCTTTTATAGGTGGATCCAGCAGTCTGGCAACGCCCAC
AGTTACCACAACACAGAAAACTGATCGTGCTATAAAATGGACGCTAAACTATGAAAACAGTGTGACATTGTTCTCTGTTCTTCCAGAGCC
AGTAACATGCTTGCTCGTGCTTTCTACTTCTAGCTGATCATTCTTTTCCCAACATATATTTACAAATTTACCAAATTTTACCTAGAATTT
TAGGACCAAATGGTTCTCACTCTTTATGCTGCAAAGACCTGGATGATGTTTGGTAACTATAGAAAAATAGAAATTACACTCAGGATCACT
GTTACTGCTATTGCCACTGATGATTCCTGCAAAAATATAATCGAAGTTTTCCATCAAATGTATAATATGCTATTAATACACATTAGATGA
TAACAGTTGTTCCATGAATGATTCTATGAAGCTATGCATCTTAGACCTCTTGAGCTGTGAATTAGCACTATTTTCTATAGTTACTTATTC
TCTGGATCATTTTATAATTTCCATATTAATTTCAAATATGCTCGTGTTATTCTTCAGTGATTTCCACAATTGTGCATTTTATTCTTTGGT
TTAAGTACTGAAGCATATAATGAAAGTAATTGCTAAGTAGCAGCTTAAAAATTCAATTATCCGATTGTATTTAACATCTTTAAGAGCATG
ATCATAAAGAGCTATTTTTGACACCCCCCCCCCACTTTTTTAACATTTAGAGTTAGTAAGGGTTTTATATCTCTTCTGTCCATATTGTTT
TCAAAGGAATGAGGTGTTTAGGTGGCTGGAAAAGCATTTGTAGGAAGTTAGATTTGAATATAGACAAGGTGGGTTATTCACGTTGAGAAT
GTTATTTGAAGAATGCCTGTGAAGCCAGGTGTGGGTTCTACTCAGTGCCATAGATAGACTGAGTCTTCTCTCGTAGGTTACCATTACATA
GTAATTTTGATTCTGAATTTCACATTAAATTATTTGAGTTTATACAGACCTAAATTTTAAAATCTGTACATATATTATTTTGATGTATTA
AGATGAATATTGCTGATTTAAATTTTATTTATGCACATACTTAAAGGACAGAAATGTCTGGGAAAGTAATTGTTAAATAATGATATGTAA
CTTTTTAACTTTTTAAATAAATAACAAGATTTTTAATGTGTGTCTCCCTCAGGGTTGTTTAAAGTTTTTTTTCTCCCTCAAGTATAAATA
GTGGTAACTATATGTTTTGTATCTTCTAGCACCAACTGCTGTAAAGCAATGCTGCAAATAATGCTTGAATACAAGTGGCTAAGCCAACAA
CAGAATAAATACTTTTATAGTAGTTTTATAATCCTGAAATTCGAAAGCTTTCCCAATTGCACTTGCATCTAAACAAAACTGTTGCAGTTT
TTACTCTATTTATTTTGTTCCCCATGTTTATGAAAGTCCTGCACAGTTTCAAAGGCATGGTAAATAATATATCAATGTTTATGTAGTCTG
TTACAGAAACAGCTATAGATAACATTATCCAGTGAAGAGCAAAATTCAAGCTTTAGAAAATATTCATGCATGCAATTTTGACATATCTAA
AAATAGGTTTTTGTATATTTATGGTGGGAGGTGGTTGGGAACTTTTAACAAAATGGGGTGTTAATTTTTGTACAGTCTGTGGGCATTTAC
ACATTTTTAATGTATTAAAATTTGGTAATTATGTGTACATTAAATTAATAAAAGTTACTTCTAGTTATGATTTGTGAATTCCCTAAGACC
TTGGATTTTTTTAAGTAACTTTATATCAGAAATGATACTGCATCTTTATATTTTTAAAATTGTATTGCTGCTCAAGAATGGTACCCTCTT
GTCAAAAAGGCATACATTCATAATTGTACATTCAGCATTGTAAATAATCTTATGAAACCTTTTTTGATTGAAGCTATTCAAAATAAAAAT

>49633_49633_2_LRCH1-ATP13A3_LRCH1_chr13_47127838_ENST00000389797_ATP13A3_chr3_194126845_ENST00000256031_length(amino acids)=174AA_BP=0
MYFAFGVFFLQPRAQGKQHFPHRSTDSCLHRVREVVPGGCGTGKFLQFPGAQVQPPGVGRLLKRALQTPVQGQVEAPAATAATTRPAGGA

--------------------------------------------------------------
>49633_49633_3_LRCH1-ATP13A3_LRCH1_chr13_47127838_ENST00000389798_ATP13A3_chr3_194126845_ENST00000256031_length(transcript)=3941nt_BP=504nt
CTTCAAGACCGAGCTGCCACGGCCGCCTCCCCGCCCGCCCCCCATTCTACGCGCCTGCCCACACCCTCCTCCCCTCCTTCCAGCGCCTTT
CGGTGGAGCACTGCGGCACTCAGCCCGAGCTGCCGTTTTCCCCTCGCGGGGAACGCTGTGACCCCCCCGCAGGAGCGGCGGGGCGGGGTG
GGGGGGCCCGGGAGAAGATGGCGACGCCGGGAAGCGAACCCCAACCTTTCGTCCCGGCCCTTTCGGTAGCTACTCTGCACCCACTTCATC
ATCCCCACCACCACCACCACCACCATCAGCACCACGGAGGAACCGGCGCCCCCGGCGGGGCGGGTGGTGGCGGCGGTGGCAGCGGGGGCT
TCAACCTGCCCTTGAACCGGGGTCTGGAGCGCGCGCTTGAGGAGGCGGCCAACTCCGGGGGGCTGAACCTGAGCGCCAGGAAATTGAAGG
AATTTCCCCGTACCGCAGCCCCCGGGCACGACCTCTCGGACACGGTGCAGGCAGGAGTCAGTGGATCGGTGGGGAAAATGCTGCTTACCC
TGGGCCCTGGGCTGTAGAAAGAAGACACCAAAGGCAAAGTACATGTATCTGGCGCAGGAGCTCTTGGTTGATCCAGAATGGCCACCAAAA
CCTCAGACAACCACAGAAGCTAAAGCTTTAGTTAAGGAGAATGGATCATGTCAAATCATCACCATAACATAGCAGTGAATCAGTCTCAGT
GGTATTGCTGATAGCAGTATTCAGGAATATGTGATTTTAGGAGTTTCTGATCCTGTGTGTCAGAATGGCACTAGTTCAGTTTATGTCCCT
TCTGATATAGTAGCTTATTTGACAGCTTTGCTCTTCCTTAAAATAAAAACAGAAAAATATATCGTCCTAACAGTTAAATTAACAATCAAT
CCATAAAGTCCTATATCTTCATTCAGCAACCCAAATATTACATACATTTCCAGAATTTTCTTGATTGTTACTTTCAGTGATATTCTTTAT
ATTGGGTACAGGAGAAGTTTGGTGTTTGGTAGGTTTTTCAACATTAGTTTTTGAGACTAGTTTACCTCTTCACATTTATGCTCACAACCC
TCTTGTTAGAAAAGTCTGTGTTTATATACAGGCTGTAAGTTTGTGATTGATAAAAAGAAGATGAGTGTTAATTAGCCTCCAGTGAAAATA
TACTGAAAGCCTGTTTTCATTTGATTCCAATGTTTCTTCCAAAGAATTCTGTATAAACATATGCCAATTCCCTATGATGGTCTAGAGTTA
GGAATGAGTGTTTATGGTGTTGCTTATAGAACAACTCAGGTAATCTCCATTTCTGGTTTTATATTTTCTGTACAAACTGCCTGGGTTTTA
TTTTTCTAATCAGCAAGGTGCTTCACTGCCTTCTTGAGACGCCTCTCAAAGCTCTTAAATGGCTCCTGTGCTATGTGTGGTGTTGGCAGT
CTAATTTGCTTCTGTTAAATGTTGTAGAACCTTTTTCACTAGGAAATAAGATTCATTTCTTTCGGCAGTAGATGTAGATTCATCTTTTAA
CGTTTCTTCAAATTTGTTTCTGTCAGGCTTTGTGTTATTTTAAATGGTTTTTTAAAATTTTCTTCTATGTTTTCAATTACCTAAAGACAT
AGGATAATAGTTTTTTTTAAGTTAGAATTTTACCTCATAAAATTTTTTGAGGTTTGATGTATGTCTCTGTCTTATCAATAATGAGGCTTA
AAAAATACTGGATTTGAATGGCTGCCGTTTTTTCAAAGCAATATGAATTTGATGAGTTTGTTTTATGCCATTAGGTGGCGCCAGAGGTCA
GAACATGTCTATTTTGAATTGGATCGTTACAAATGAGCATATTTGATGCGGAAATTTCTGGGAGAAAAAAAATTGAGGAAATAAAGTTAA
AAAATTGACATTCATTGAGCCAAAAGAGATGTGGAGAAACATTTTTCACCTTTCTGTTTGGCCTGATTAACATTTAAATTCTTGCCAAAA
TTAAGGTAACTTTTAAAAAACACCTTTTATAGGTGGATCCAGCAGTCTGGCAACGCCCACAGTTACCACAACACAGAAAACTGATCGTGC
TATAAAATGGACGCTAAACTATGAAAACAGTGTGACATTGTTCTCTGTTCTTCCAGAGCCAGTAACATGCTTGCTCGTGCTTTCTACTTC
TAGCTGATCATTCTTTTCCCAACATATATTTACAAATTTACCAAATTTTACCTAGAATTTTAGGACCAAATGGTTCTCACTCTTTATGCT
GCAAAGACCTGGATGATGTTTGGTAACTATAGAAAAATAGAAATTACACTCAGGATCACTGTTACTGCTATTGCCACTGATGATTCCTGC
AAAAATATAATCGAAGTTTTCCATCAAATGTATAATATGCTATTAATACACATTAGATGATAACAGTTGTTCCATGAATGATTCTATGAA
GCTATGCATCTTAGACCTCTTGAGCTGTGAATTAGCACTATTTTCTATAGTTACTTATTCTCTGGATCATTTTATAATTTCCATATTAAT
TTCAAATATGCTCGTGTTATTCTTCAGTGATTTCCACAATTGTGCATTTTATTCTTTGGTTTAAGTACTGAAGCATATAATGAAAGTAAT
TGCTAAGTAGCAGCTTAAAAATTCAATTATCCGATTGTATTTAACATCTTTAAGAGCATGATCATAAAGAGCTATTTTTGACACCCCCCC
CCCACTTTTTTAACATTTAGAGTTAGTAAGGGTTTTATATCTCTTCTGTCCATATTGTTTTCAAAGGAATGAGGTGTTTAGGTGGCTGGA
AAAGCATTTGTAGGAAGTTAGATTTGAATATAGACAAGGTGGGTTATTCACGTTGAGAATGTTATTTGAAGAATGCCTGTGAAGCCAGGT
GTGGGTTCTACTCAGTGCCATAGATAGACTGAGTCTTCTCTCGTAGGTTACCATTACATAGTAATTTTGATTCTGAATTTCACATTAAAT
TATTTGAGTTTATACAGACCTAAATTTTAAAATCTGTACATATATTATTTTGATGTATTAAGATGAATATTGCTGATTTAAATTTTATTT
ATGCACATACTTAAAGGACAGAAATGTCTGGGAAAGTAATTGTTAAATAATGATATGTAACTTTTTAACTTTTTAAATAAATAACAAGAT
TTTTAATGTGTGTCTCCCTCAGGGTTGTTTAAAGTTTTTTTTCTCCCTCAAGTATAAATAGTGGTAACTATATGTTTTGTATCTTCTAGC
ACCAACTGCTGTAAAGCAATGCTGCAAATAATGCTTGAATACAAGTGGCTAAGCCAACAACAGAATAAATACTTTTATAGTAGTTTTATA
ATCCTGAAATTCGAAAGCTTTCCCAATTGCACTTGCATCTAAACAAAACTGTTGCAGTTTTTACTCTATTTATTTTGTTCCCCATGTTTA
TGAAAGTCCTGCACAGTTTCAAAGGCATGGTAAATAATATATCAATGTTTATGTAGTCTGTTACAGAAACAGCTATAGATAACATTATCC
AGTGAAGAGCAAAATTCAAGCTTTAGAAAATATTCATGCATGCAATTTTGACATATCTAAAAATAGGTTTTTGTATATTTATGGTGGGAG
GTGGTTGGGAACTTTTAACAAAATGGGGTGTTAATTTTTGTACAGTCTGTGGGCATTTACACATTTTTAATGTATTAAAATTTGGTAATT
ATGTGTACATTAAATTAATAAAAGTTACTTCTAGTTATGATTTGTGAATTCCCTAAGACCTTGGATTTTTTTAAGTAACTTTATATCAGA
AATGATACTGCATCTTTATATTTTTAAAATTGTATTGCTGCTCAAGAATGGTACCCTCTTGTCAAAAAGGCATACATTCATAATTGTACA

>49633_49633_3_LRCH1-ATP13A3_LRCH1_chr13_47127838_ENST00000389798_ATP13A3_chr3_194126845_ENST00000256031_length(amino acids)=193AA_BP=0
MYFAFGVFFLQPRAQGKQHFPHRSTDSCLHRVREVVPGGCGTGKFLQFPGAQVQPPGVGRLLKRALQTPVQGQVEAPAATAATTRPAGGA
GSSVVLMVVVVVVGMMKWVQSSYRKGRDERLGFASRRRHLLPGPPTPPRRSCGGVTAFPARGKRQLGLSAAVLHRKALEGGEEGVGRRVE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LRCH1-ATP13A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRCH1-ATP13A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRCH1-ATP13A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource