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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRIG1-SLC25A26 (FusionGDB2 ID:49680)

Fusion Gene Summary for LRIG1-SLC25A26

check button Fusion gene summary
Fusion gene informationFusion gene name: LRIG1-SLC25A26
Fusion gene ID: 49680
HgeneTgene
Gene symbol

LRIG1

SLC25A26

Gene ID

26018

115286

Gene nameleucine rich repeats and immunoglobulin like domains 1solute carrier family 25 member 26
SynonymsLIG-1|LIG1COXPD28|SAMC
Cytomap

3p14.1

3p14.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 1leucine-rich repeat protein LRIG1ortholog of mouse integral membrane glycoprotein LIG-1S-adenosylmethionine mitochondrial carrier proteinmitochondrial S-adenosylmethionine transportersolute carrier family 25 (S-adenosylmethionine carrier), member 26solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26
Modification date2020032020200326
UniProtAcc

Q96JA1

.
Ensembl transtripts involved in fusion geneENST00000273261, ENST00000383703, 
ENST00000496559, 		ENST00000413054, 
ENST00000484768, ENST00000536651, 
ENST00000336733, ENST00000354883, 
Fusion gene scores* DoF score11 X 13 X 6=85810 X 11 X 8=880
# samples 1414
** MAII scorelog2(14/858*10)=-2.61555082055458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/880*10)=-2.65207669657969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRIG1 [Title/Abstract] AND SLC25A26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRIG1(66436404)-SLC25A26(66419901), # samples:2
Anticipated loss of major functional domain due to fusion event.LRIG1-SLC25A26 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LRIG1-SLC25A26 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
LRIG1-SLC25A26 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LRIG1-SLC25A26 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRIG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC25A26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3850LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
ChimerDB4OVTCGA-29-1697-01ALRIG1chr3

66436405

-SLC25A26chr3

66419902

+
ChimerDB4OVTCGA-29-1697LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
ChimerDB4UCECTCGA-D1-A179-01ALRIG1chr3

66550614

-SLC25A26chr3

66419902

+
ChimerDB4UCECTCGA-D1-A179LRIG1chr3

66550613

-SLC25A26chr3

66419901

+


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Fusion Gene ORF analysis for LRIG1-SLC25A26

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000273261ENST00000413054LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000273261ENST00000413054LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000273261ENST00000413054LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000273261ENST00000413054LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000273261ENST00000484768LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000273261ENST00000484768LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000273261ENST00000484768LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000273261ENST00000484768LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000273261ENST00000536651LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000273261ENST00000536651LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000273261ENST00000536651LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000273261ENST00000536651LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000383703ENST00000413054LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000383703ENST00000413054LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000383703ENST00000413054LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000383703ENST00000413054LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000383703ENST00000484768LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000383703ENST00000484768LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000383703ENST00000484768LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000383703ENST00000484768LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000383703ENST00000536651LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5CDS-3UTRENST00000383703ENST00000536651LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000383703ENST00000536651LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
5CDS-3UTRENST00000383703ENST00000536651LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
5UTR-3CDSENST00000496559ENST00000336733LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5UTR-3CDSENST00000496559ENST00000336733LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5UTR-3CDSENST00000496559ENST00000354883LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5UTR-3CDSENST00000496559ENST00000354883LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5UTR-3UTRENST00000496559ENST00000413054LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5UTR-3UTRENST00000496559ENST00000413054LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5UTR-3UTRENST00000496559ENST00000484768LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5UTR-3UTRENST00000496559ENST00000484768LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
5UTR-3UTRENST00000496559ENST00000536651LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
5UTR-3UTRENST00000496559ENST00000536651LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
Frame-shiftENST00000273261ENST00000336733LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
Frame-shiftENST00000273261ENST00000336733LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
Frame-shiftENST00000273261ENST00000354883LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
Frame-shiftENST00000273261ENST00000354883LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
Frame-shiftENST00000383703ENST00000336733LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
Frame-shiftENST00000383703ENST00000336733LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
Frame-shiftENST00000383703ENST00000354883LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
Frame-shiftENST00000383703ENST00000354883LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
In-frameENST00000273261ENST00000336733LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
In-frameENST00000273261ENST00000336733LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
In-frameENST00000273261ENST00000354883LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
In-frameENST00000273261ENST00000354883LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
In-frameENST00000383703ENST00000336733LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
In-frameENST00000383703ENST00000336733LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
In-frameENST00000383703ENST00000354883LRIG1chr3

66436404

-SLC25A26chr3

66419901

+
In-frameENST00000383703ENST00000354883LRIG1chr3

66436405

-SLC25A26chr3

66419902

+
intron-3CDSENST00000496559ENST00000336733LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
intron-3CDSENST00000496559ENST00000336733LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
intron-3CDSENST00000496559ENST00000354883LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
intron-3CDSENST00000496559ENST00000354883LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
intron-3UTRENST00000496559ENST00000413054LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
intron-3UTRENST00000496559ENST00000413054LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
intron-3UTRENST00000496559ENST00000484768LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
intron-3UTRENST00000496559ENST00000484768LRIG1chr3

66550613

-SLC25A26chr3

66419901

+
intron-3UTRENST00000496559ENST00000536651LRIG1chr3

66550614

-SLC25A26chr3

66419902

+
intron-3UTRENST00000496559ENST00000536651LRIG1chr3

66550613

-SLC25A26chr3

66419901

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LRIG1-SLC25A26


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LRIG1chr366436404-SLC25A26chr366419901+0.0048218670.9951781
LRIG1chr366436404-SLC25A26chr366419901+0.0048218670.9951781
LRIG1chr366436404-SLC25A26chr366419901+0.0048218670.9951781
LRIG1chr366550613-SLC25A26chr366419901+0.0003579640.999642
LRIG1chr366550613-SLC25A26chr366419901+0.0003579640.999642
LRIG1chr366436404-SLC25A26chr366419901+0.0048218670.9951781
LRIG1chr366436404-SLC25A26chr366419901+0.0048218670.9951781
LRIG1chr366436404-SLC25A26chr366419901+0.0048218670.9951781
LRIG1chr366550613-SLC25A26chr366419901+0.0003579640.999642
LRIG1chr366550613-SLC25A26chr366419901+0.0003579640.999642

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LRIG1-SLC25A26


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:66436404/chr3:66419901)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRIG1

Q96JA1

.
FUNCTION: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319520_5245961094.0Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420520_5246201071.0Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319520_5245961094.0Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420520_5246201071.0Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-131935_685961094.0DomainNote=LRRNT
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319440_4915961094.0DomainNote=LRRCT
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319495_5945961094.0DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-142035_686201071.0DomainNote=LRRNT
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420440_4916201071.0DomainNote=LRRCT
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420495_5946201071.0DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-131935_685961094.0DomainNote=LRRNT
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319440_4915961094.0DomainNote=LRRCT
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319495_5945961094.0DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-142035_686201071.0DomainNote=LRRNT
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420440_4916201071.0DomainNote=LRRCT
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420495_5946201071.0DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319116_1375961094.0RepeatNote=LRR 3
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319140_1615961094.0RepeatNote=LRR 4
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319164_1855961094.0RepeatNote=LRR 5
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319189_2105961094.0RepeatNote=LRR 6
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319212_2335961094.0RepeatNote=LRR 7
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319236_2575961094.0RepeatNote=LRR 8
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319260_2815961094.0RepeatNote=LRR 9
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319284_3055961094.0RepeatNote=LRR 10
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319308_3295961094.0RepeatNote=LRR 11
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319332_3535961094.0RepeatNote=LRR 12
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319356_3785961094.0RepeatNote=LRR 13
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319383_4045961094.0RepeatNote=LRR 14
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319407_4285961094.0RepeatNote=LRR 15
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-131969_905961094.0RepeatNote=LRR 1
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-131993_1145961094.0RepeatNote=LRR 2
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420116_1376201071.0RepeatNote=LRR 3
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420140_1616201071.0RepeatNote=LRR 4
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420164_1856201071.0RepeatNote=LRR 5
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420189_2106201071.0RepeatNote=LRR 6
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420212_2336201071.0RepeatNote=LRR 7
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420236_2576201071.0RepeatNote=LRR 8
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420260_2816201071.0RepeatNote=LRR 9
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420284_3056201071.0RepeatNote=LRR 10
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420308_3296201071.0RepeatNote=LRR 11
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420332_3536201071.0RepeatNote=LRR 12
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420356_3786201071.0RepeatNote=LRR 13
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420383_4046201071.0RepeatNote=LRR 14
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420407_4286201071.0RepeatNote=LRR 15
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-142069_906201071.0RepeatNote=LRR 1
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-142093_1146201071.0RepeatNote=LRR 2
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319116_1375961094.0RepeatNote=LRR 3
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319140_1615961094.0RepeatNote=LRR 4
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319164_1855961094.0RepeatNote=LRR 5
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319189_2105961094.0RepeatNote=LRR 6
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319212_2335961094.0RepeatNote=LRR 7
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319236_2575961094.0RepeatNote=LRR 8
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319260_2815961094.0RepeatNote=LRR 9
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319284_3055961094.0RepeatNote=LRR 10
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319308_3295961094.0RepeatNote=LRR 11
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319332_3535961094.0RepeatNote=LRR 12
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319356_3785961094.0RepeatNote=LRR 13
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319383_4045961094.0RepeatNote=LRR 14
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319407_4285961094.0RepeatNote=LRR 15
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-131969_905961094.0RepeatNote=LRR 1
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-131993_1145961094.0RepeatNote=LRR 2
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420116_1376201071.0RepeatNote=LRR 3
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420140_1616201071.0RepeatNote=LRR 4
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420164_1856201071.0RepeatNote=LRR 5
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420189_2106201071.0RepeatNote=LRR 6
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420212_2336201071.0RepeatNote=LRR 7
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420236_2576201071.0RepeatNote=LRR 8
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420260_2816201071.0RepeatNote=LRR 9
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420284_3056201071.0RepeatNote=LRR 10
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420308_3296201071.0RepeatNote=LRR 11
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420332_3536201071.0RepeatNote=LRR 12
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420356_3786201071.0RepeatNote=LRR 13
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420383_4046201071.0RepeatNote=LRR 14
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420407_4286201071.0RepeatNote=LRR 15
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-142069_906201071.0RepeatNote=LRR 1
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-142093_1146201071.0RepeatNote=LRR 2
TgeneSLC25A26chr3:66436404chr3:66419901ENST0000033673359177_265101187.0RepeatNote=Solcar 3
TgeneSLC25A26chr3:66436405chr3:66419902ENST0000033673359177_265101187.0RepeatNote=Solcar 3
TgeneSLC25A26chr3:66436404chr3:66419901ENST0000033673359142_162101187.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A26chr3:66436404chr3:66419901ENST0000033673359182_202101187.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A26chr3:66436404chr3:66419901ENST0000033673359238_258101187.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A26chr3:66436405chr3:66419902ENST0000033673359142_162101187.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A26chr3:66436405chr3:66419902ENST0000033673359182_202101187.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A26chr3:66436405chr3:66419902ENST0000033673359238_258101187.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319599_6885961094.0DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319693_7795961094.0DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420599_6886201071.0DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420693_7796201071.0DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319599_6885961094.0DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319693_7795961094.0DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420599_6886201071.0DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420693_7796201071.0DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-131935_7945961094.0Topological domainExtracellular
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319816_10935961094.0Topological domainCytoplasmic
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-142035_7946201071.0Topological domainExtracellular
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420816_10936201071.0Topological domainCytoplasmic
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-131935_7945961094.0Topological domainExtracellular
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319816_10935961094.0Topological domainCytoplasmic
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-142035_7946201071.0Topological domainExtracellular
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420816_10936201071.0Topological domainCytoplasmic
HgeneLRIG1chr3:66436404chr3:66419901ENST00000273261-1319795_8155961094.0TransmembraneHelical
HgeneLRIG1chr3:66436404chr3:66419901ENST00000383703-1420795_8156201071.0TransmembraneHelical
HgeneLRIG1chr3:66436405chr3:66419902ENST00000273261-1319795_8155961094.0TransmembraneHelical
HgeneLRIG1chr3:66436405chr3:66419902ENST00000383703-1420795_8156201071.0TransmembraneHelical
TgeneSLC25A26chr3:66436404chr3:66419901ENST00000336733594_77101187.0RepeatNote=Solcar 1
TgeneSLC25A26chr3:66436404chr3:66419901ENST000003367335986_168101187.0RepeatNote=Solcar 2
TgeneSLC25A26chr3:66436405chr3:66419902ENST00000336733594_77101187.0RepeatNote=Solcar 1
TgeneSLC25A26chr3:66436405chr3:66419902ENST000003367335986_168101187.0RepeatNote=Solcar 2
TgeneSLC25A26chr3:66436404chr3:66419901ENST000003367335949_69101187.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A26chr3:66436404chr3:66419901ENST00000336733595_25101187.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A26chr3:66436404chr3:66419901ENST000003367335985_105101187.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A26chr3:66436405chr3:66419902ENST000003367335949_69101187.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A26chr3:66436405chr3:66419902ENST00000336733595_25101187.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A26chr3:66436405chr3:66419902ENST000003367335985_105101187.0TransmembraneHelical%3B Name%3D3


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Fusion Gene Sequence for LRIG1-SLC25A26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LRIG1-SLC25A26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRIG1-SLC25A26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRIG1-SLC25A26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource