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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRP10-LRP10 (FusionGDB2 ID:49707)

Fusion Gene Summary for LRP10-LRP10

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP10-LRP10
Fusion gene ID: 49707
HgeneTgene
Gene symbol

LRP10

LRP10

Gene ID

26020

26020

Gene nameLDL receptor related protein 10LDL receptor related protein 10
SynonymsLRP-10|LRP9|MST087|MSTP087LRP-10|LRP9|MST087|MSTP087
Cytomap

14q11.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 10low-density lipoprotein receptor-related protein 10
Modification date2020031520200315
UniProtAcc

Q7Z4F1

Q7Z4F1

Ensembl transtripts involved in fusion geneENST00000470660, ENST00000359591, 
ENST00000546834, 		ENST00000359591, 
ENST00000546834, ENST00000470660, 
Fusion gene scores* DoF score9 X 8 X 3=2164 X 5 X 3=60
# samples 95
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP10 [Title/Abstract] AND LRP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRP10(23346026)-LRP10(23346237), # samples:1
LRP10(23346237)-LRP10(23346026), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRP10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA469296LRP10chr14

23346026

+LRP10chr14

23346237

-
ChiTaRS5.0N/AAA469376LRP10chr14

23346237

+LRP10chr14

23346026

-


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Fusion Gene ORF analysis for LRP10-LRP10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000470660ENST00000359591LRP10chr14

23346026

+LRP10chr14

23346237

-
3UTR-3CDSENST00000470660ENST00000546834LRP10chr14

23346026

+LRP10chr14

23346237

-
3UTR-3UTRENST00000470660ENST00000470660LRP10chr14

23346026

+LRP10chr14

23346237

-
3UTR-intronENST00000470660ENST00000359591LRP10chr14

23346237

+LRP10chr14

23346026

-
3UTR-intronENST00000470660ENST00000470660LRP10chr14

23346237

+LRP10chr14

23346026

-
3UTR-intronENST00000470660ENST00000546834LRP10chr14

23346237

+LRP10chr14

23346026

-
5CDS-3UTRENST00000359591ENST00000470660LRP10chr14

23346026

+LRP10chr14

23346237

-
5CDS-3UTRENST00000546834ENST00000470660LRP10chr14

23346026

+LRP10chr14

23346237

-
5CDS-intronENST00000359591ENST00000359591LRP10chr14

23346237

+LRP10chr14

23346026

-
5CDS-intronENST00000359591ENST00000470660LRP10chr14

23346237

+LRP10chr14

23346026

-
5CDS-intronENST00000359591ENST00000546834LRP10chr14

23346237

+LRP10chr14

23346026

-
5CDS-intronENST00000546834ENST00000359591LRP10chr14

23346237

+LRP10chr14

23346026

-
5CDS-intronENST00000546834ENST00000470660LRP10chr14

23346237

+LRP10chr14

23346026

-
5CDS-intronENST00000546834ENST00000546834LRP10chr14

23346237

+LRP10chr14

23346026

-
In-frameENST00000359591ENST00000359591LRP10chr14

23346026

+LRP10chr14

23346237

-
In-frameENST00000359591ENST00000546834LRP10chr14

23346026

+LRP10chr14

23346237

-
In-frameENST00000546834ENST00000359591LRP10chr14

23346026

+LRP10chr14

23346237

-
In-frameENST00000546834ENST00000546834LRP10chr14

23346026

+LRP10chr14

23346237

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LRP10-LRP10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRP10-LRP10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:23346026/chr14:23346237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP10

Q7Z4F1

LRP10

Q7Z4F1

FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). {ECO:0000250}.FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67139_175518714.0DomainLDL-receptor class A 1
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67192_305518714.0DomainCUB 2
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+6728_136518714.0DomainCUB 1
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67307_354518714.0DomainLDL-receptor class A 2
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67355_397518714.0DomainLDL-receptor class A 3
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67398_434518714.0DomainLDL-receptor class A 4
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68139_175518557.0DomainLDL-receptor class A 1
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68192_305518557.0DomainCUB 2
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+6828_136518557.0DomainCUB 1
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68307_354518557.0DomainLDL-receptor class A 2
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68355_397518557.0DomainLDL-receptor class A 3
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68398_434518557.0DomainLDL-receptor class A 4
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+6717_440518714.0Topological domainExtracellular
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+6817_440518557.0Topological domainExtracellular
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67441_461518714.0TransmembraneHelical
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68441_461518557.0TransmembraneHelical
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107545_5790714.0Compositional biasNote=Arg-rich
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107614_6780714.0Compositional biasNote=Pro-rich
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408545_5790557.0Compositional biasNote=Arg-rich
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408614_6780557.0Compositional biasNote=Pro-rich
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107139_1750714.0DomainLDL-receptor class A 1
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107192_3050714.0DomainCUB 2
TgeneLRP10chr14:23346026chr14:23346237ENST000003595910728_1360714.0DomainCUB 1
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107307_3540714.0DomainLDL-receptor class A 2
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107355_3970714.0DomainLDL-receptor class A 3
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107398_4340714.0DomainLDL-receptor class A 4
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408139_1750557.0DomainLDL-receptor class A 1
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408192_3050557.0DomainCUB 2
TgeneLRP10chr14:23346026chr14:23346237ENST000005468340828_1360557.0DomainCUB 1
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408307_3540557.0DomainLDL-receptor class A 2
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408355_3970557.0DomainLDL-receptor class A 3
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408398_4340557.0DomainLDL-receptor class A 4
TgeneLRP10chr14:23346026chr14:23346237ENST000003595910717_4400714.0Topological domainExtracellular
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107462_7130714.0Topological domainCytoplasmic
TgeneLRP10chr14:23346026chr14:23346237ENST000005468340817_4400557.0Topological domainExtracellular
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408462_7130557.0Topological domainCytoplasmic
TgeneLRP10chr14:23346026chr14:23346237ENST0000035959107441_4610714.0TransmembraneHelical
TgeneLRP10chr14:23346026chr14:23346237ENST0000054683408441_4610557.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67545_579518714.0Compositional biasNote=Arg-rich
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67614_678518714.0Compositional biasNote=Pro-rich
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68545_579518557.0Compositional biasNote=Arg-rich
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68614_678518557.0Compositional biasNote=Pro-rich
HgeneLRP10chr14:23346026chr14:23346237ENST00000359591+67462_713518714.0Topological domainCytoplasmic
HgeneLRP10chr14:23346026chr14:23346237ENST00000546834+68462_713518557.0Topological domainCytoplasmic


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Fusion Gene Sequence for LRP10-LRP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LRP10-LRP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRP10-LRP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRP10-LRP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource