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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LRP1B-HECW2 (FusionGDB2 ID:49730)

Fusion Gene Summary for LRP1B-HECW2

Fusion gene summary

Fusion gene information	Fusion gene name: LRP1B-HECW2
	Fusion gene ID: 49730
		Hgene	Tgene
	Gene symbol	LRP1B	HECW2
	Gene ID	53353	57520
	Gene name	LDL receptor related protein 1B	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
	Synonyms	LRP-1B\|LRP-DIT\|LRPDIT	NDHSAL\|NEDL2
	Cytomap	2q22.1-q22.2	2q32.3
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors)	E3 ubiquitin-protein ligase HECW2HECT-type E3 ubiquitin transferase HECW2NEDD4-like E3 ubiquitin-protein ligase 2NEDD4-related E3 ubiquitin ligase NEDL2
	Modification date	20200313	20200313
	UniProtAcc	Q9NZR2	Q9P2P5
	Ensembl transtripts involved in fusion gene	ENST00000389484, ENST00000486364,	ENST00000409111, ENST00000260983,
Fusion gene scores	* DoF score	10 X 10 X 4=400	9 X 8 X 4=288
	# samples	10	9
	** MAII score	log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LRP1B [Title/Abstract] AND HECW2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LRP1B(142567848)-HECW2(197208488), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LRP1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HECW2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-22-5482-01A	LRP1B	chr2	142567848	-	HECW2	chr2	197208488	-
ChimerDB4	LUSC	TCGA-22-5482	LRP1B	chr2	142567848	-	HECW2	chr2	197208488	-

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Fusion Gene ORF analysis for LRP1B-HECW2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000389484	ENST00000409111	LRP1B	chr2	142567848	-	HECW2	chr2	197208488	-
5UTR-3CDS	ENST00000486364	ENST00000260983	LRP1B	chr2	142567848	-	HECW2	chr2	197208488	-
5UTR-5UTR	ENST00000486364	ENST00000409111	LRP1B	chr2	142567848	-	HECW2	chr2	197208488	-
In-frame	ENST00000389484	ENST00000260983	LRP1B	chr2	142567848	-	HECW2	chr2	197208488	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000389484

LRP1B

chr2

142567848

ENST00000260983

HECW2

chr2

197208488

12511

1177

861

5603

1580

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000389484	ENST00000260983	LRP1B	chr2	142567848	-	HECW2	chr2	197208488	-	0.000431296	0.99956864

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Fusion Genomic Features for LRP1B-HECW2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRP1B-HECW2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:142567848/chr2:197208488)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP1B Q9NZR2	HECW2 Q9P2P5
FUNCTION: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269\|PubMed:12890487, ECO:0000269\|PubMed:24163370}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

31_70

4600.0

Domain

LDL-receptor class A 1

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000260983

847_874

1573.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000409111

847_874

1217.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000260983

1237_1572

1573.0

Domain

HECT

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000260983

167_301

1573.0

Domain

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000260983

807_840

1573.0

Domain

WW 1

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000260983

985_1018

1573.0

Domain

WW 2

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000409111

1237_1572

1217.0

Domain

HECT

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000409111

167_301

1217.0

Domain

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000409111

807_840

1217.0

Domain

WW 1

Tgene

HECW2

chr2:142567848

chr2:197208488

ENST00000409111

985_1018

1217.0

Domain

WW 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1005_1043

4600.0

Domain

LDL-receptor class A 7

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1052_1089

4600.0

Domain

LDL-receptor class A 8

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1094_1132

4600.0

Domain

LDL-receptor class A 9

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1135_1174

4600.0

Domain

LDL-receptor class A 10

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

116_154

4600.0

Domain

EGF-like 1

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1174_1213

4600.0

Domain

EGF-like 5

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1214_1253

4600.0

Domain

EGF-like 6

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1527_1570

4600.0

Domain

EGF-like 7

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

155_194

4600.0

Domain

EGF-like 2%3B calcium-binding

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1834_1875

4600.0

Domain

EGF-like 8

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2143_2183

4600.0

Domain

EGF-like 9

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2464_2504

4600.0

Domain

EGF-like 10

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2509_2548

4600.0

Domain

LDL-receptor class A 11

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2551_2587

4600.0

Domain

LDL-receptor class A 12

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2590_2626

4600.0

Domain

LDL-receptor class A 13

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2629_2675

4600.0

Domain

LDL-receptor class A 14

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2681_2717

4600.0

Domain

LDL-receptor class A 15

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2719_2757

4600.0

Domain

LDL-receptor class A 16

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2760_2800

4600.0

Domain

LDL-receptor class A 17

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2804_2841

4600.0

Domain

LDL-receptor class A 18

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2844_2885

4600.0

Domain

LDL-receptor class A 19

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2890_2926

4600.0

Domain

LDL-receptor class A 20

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2927_2967

4600.0

Domain

EGF-like 11

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2968_3008

4600.0

Domain

EGF-like 12%3B calcium-binding

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3273_3314

4600.0

Domain

EGF-like 13

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3316_3353

4600.0

Domain

LDL-receptor class A 21

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3356_3392

4600.0

Domain

LDL-receptor class A 22

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3395_3432

4600.0

Domain

LDL-receptor class A 23

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3435_3472

4600.0

Domain

LDL-receptor class A 24

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3475_3511

4600.0

Domain

LDL-receptor class A 25

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3514_3550

4600.0

Domain

LDL-receptor class A 26

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3552_3588

4600.0

Domain

LDL-receptor class A 27

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3593_3629

4600.0

Domain

LDL-receptor class A 28

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3631_3668

4600.0

Domain

LDL-receptor class A 29

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3673_3711

4600.0

Domain

LDL-receptor class A 30

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3714_3752

4600.0

Domain

LDL-receptor class A 31

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3761_3797

4600.0

Domain

LDL-receptor class A 32

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3801_3843

4600.0

Domain

EGF-like 14

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3844_3881

4600.0

Domain

EGF-like 15

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4171_4208

4600.0

Domain

EGF-like 16

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4213_4249

4600.0

Domain

EGF-like 17

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4249_4285

4600.0

Domain

EGF-like 18

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4285_4321

4600.0

Domain

EGF-like 19

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4321_4357

4600.0

Domain

EGF-like 20

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4357_4392

4600.0

Domain

EGF-like 21

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4390_4427

4600.0

Domain

EGF-like 22

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

471_517

4600.0

Domain

EGF-like 3

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

76_114

4600.0

Domain

LDL-receptor class A 2

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

794_834

4600.0

Domain

EGF-like 4

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

844_882

4600.0

Domain

LDL-receptor class A 3

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

885_923

4600.0

Domain

LDL-receptor class A 4

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

926_963

4600.0

Domain

LDL-receptor class A 5

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

966_1003

4600.0

Domain

LDL-receptor class A 6

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4492_4495

4600.0

Motif

Endocytosis signal

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4559_4562

4600.0

Motif

Endocytosis signal

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1300_1346

4600.0

Repeat

Note=LDL-receptor class B 8

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1347_1389

4600.0

Repeat

Note=LDL-receptor class B 9

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1390_1436

4600.0

Repeat

Note=LDL-receptor class B 10

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1437_1480

4600.0

Repeat

Note=LDL-receptor class B 11

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1481_1522

4600.0

Repeat

Note=LDL-receptor class B 12

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1618_1660

4600.0

Repeat

Note=LDL-receptor class B 13

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1661_1704

4600.0

Repeat

Note=LDL-receptor class B 14

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1705_1744

4600.0

Repeat

Note=LDL-receptor class B 15

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1745_1787

4600.0

Repeat

Note=LDL-receptor class B 16

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1922_1964

4600.0

Repeat

Note=LDL-receptor class B 17

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

1965_2007

4600.0

Repeat

Note=LDL-receptor class B 28

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2008_2051

4600.0

Repeat

Note=LDL-receptor class B 19

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2052_2095

4600.0

Repeat

Note=LDL-receptor class B 20

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2239_2280

4600.0

Repeat

Note=LDL-receptor class B 21

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2281_2329

4600.0

Repeat

Note=LDL-receptor class B 22

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2330_2374

4600.0

Repeat

Note=LDL-receptor class B 23

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2375_2416

4600.0

Repeat

Note=LDL-receptor class B 24

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

2417_2459

4600.0

Repeat

Note=LDL-receptor class B 25

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

295_337

4600.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3055_3098

4600.0

Repeat

Note=LDL-receptor class B 26

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3099_3141

4600.0

Repeat

Note=LDL-receptor class B 27

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3142_3185

4600.0

Repeat

Note=LDL-receptor class B 28

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3186_3224

4600.0

Repeat

Note=LDL-receptor class B 29

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3225_3268

4600.0

Repeat

Note=LDL-receptor class B 30

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

338_381

4600.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

382_425

4600.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3933_3980

4600.0

Repeat

Note=LDL-receptor class B 31

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

3981_4038

4600.0

Repeat

Note=LDL-receptor class B 32

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4039_4082

4600.0

Repeat

Note=LDL-receptor class B 33

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4083_4127

4600.0

Repeat

Note=LDL-receptor class B 34

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

568_610

4600.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

611_656

4600.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

657_706

4600.0

Repeat

Note=LDL-receptor class B 6

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

707_750

4600.0

Repeat

Note=LDL-receptor class B 7

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

25_4444

4600.0

Topological domain

Extracellular

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4468_4599

4600.0

Topological domain

Cytoplasmic

Hgene

LRP1B

chr2:142567848

chr2:197208488

ENST00000389484

4445_4467

4600.0

Transmembrane

Helical

Top

Fusion Gene Sequence for LRP1B-HECW2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>49730_49730_1_LRP1B-HECW2_LRP1B_chr2_142567848_ENST00000389484_HECW2_chr2_197208488_ENST00000260983_length(transcript)=12511nt_BP=1177nt
AAAGACAGAACCCCAGAGAAAAACGCTGCCAATTCGTTGCTTTATTGTTCCCTGCCTGGGGACCTCAATAGCCTTTTCCATTAACCTTCC
CTTCTTACGCAACGGTTAATGACTTTGGGGGTTGTTTTGCTTTCTGTTTCTGCTGAGTCACTAAATTTTGCCTCTTTGTCCCCAGGTGCT
GCTCAGCATAAAAGTTAAAAGTGCAATTCAGGAAGTACTGGGATTCTGTGTAGAGCCGAGGAAACCATTTCCCTAAGAGAAGCTCTGTTC
CTTGGCTTGTCCTTCCTTCCCGGGAAGGAAGCTTCCGAGGAACGAAGGGAGAAGCTTTGTTTTGCCTGCAGAAGCAGCCCTGTGCTCGGC
TGAGGGTTCTCAGCTGGCTGTGAACTGCGGAGCATTGTAGGCGCCTGGCTGGCTCAGGCCAATGCAGAAGTCTCTCCCTTCTCCAAAGAC
CCAAATCCCCACAGAACCAGCTTCGAGTTACTTTCCCTTCAAGGGGATTAAAATAATTGTGATTTGTGGCGCTCTCCGTTCGCGGTGGTA
TTTTCCTGTTGTGTTAAATGCCTCTTATTAAGTAATAGATGTGATTTATGTGAACGACGAAGGGGTGTGTGGTGGATTCGGTGATTAATC
AGTGAATTCCCATCCGCTGGCATCTCTCACTGCCCCTCTTGCGTGATGTAAGATCAGACGTACCCTGCATTGAAAAGTCAAGACACACGG
GCGTCTCGCTCGCGCTCACACACGCTCTGCCTCCTCTCTCCCGCACGCGCGCATCCCTCCACCTTCCACATCCTGCTCCAGGCAGGAGAA
GGCTGACTGGCTGGACTCATTGAGCTGAAGAATTTCCAGTGACATTTGTAAATGACGCCGCTCGATTCCAGGCTCCAAGCGGCCCCTGCC
GCCGCCGCCGCCGCCGGGCCGAAGGTGCCGCCGAGCAGTCTCCAGCGCAGGCTTCCTTACCGGGCGACCACAATGTCCGAGTTTCTCCTC
GCCTTACTCACTCTCTCGGGATTATTGCCGATTGCCAGGGTGCTGACCGTGGGAGCCGACCGAGATCAGCAGTTGTGTGATCCTGGTGAA
TTTCTTTGCCACGATCACGTGACTTGTGTCTCCCAGAGCTGGCTGTGTGATGGGGACCCTGACTGCCCTGATGATTCAGACGAGTCTTTA
GATACCTATGAGAATTCTCCAGCCAACTTCTGGGATTCTAAGAACAGGGGTGTGACTGGAACACAAAAAGGGCAAATTGTATGGAGAATT
GAGCCTGGGCCCTATTTCATGGAACCGGAGATAAAAATCTGTTTTAAATATTACCACGGCATTAGTGGAGCCCTGCGAGCCACGACCCCC
TGCATCACCGTGAAGAACCCAGCTGTGATGATGGGGGCAGAAGGCATGGAGGGAGGTGCTTCAGGAAACCTGCATTCTCGAAAACTTGTT
AGCTTTACATTGTCAGATCTTAGGGCAGTTGGGCTAAAGAAAGGGATGTTCTTCAATCCTGACCCTTATCTTAAGATGTCAATTCAGCCA
GGAAAGAAGAGCAGTTTCCCCACCTGTGCCCACCACGGGCAGGAGAGACGGTCTACTATCATCAGTAACACCACCAATCCAATTTGGCAC
CGAGAGAAATATTCCTTTTTTGCACTTCTTACTGATGTCTTAGAAATTGAAATTAAAGACAAATTTGCCAAGAGCCGTCCCATCATCAAG
CGTTTTCTGGGGAAACTAACCATTCCAGTCCAGAGGCTGCTGGAGCGACAAGCCATCGGTGATCAAATGCTCAGCTACAACCTTGGCAGA
AGGCTCCCAGCTGACCACGTGAGTGGGTACCTCCAGTTTAAAGTGGAGGTTACGTCTTCTGTTCATGAAGATGCCTCTCCAGAAGCTGTT
GGCACAATACTTGGAGTCAATTCTGTGAATGGAGACTTAGGTAGCCCTTCCGATGACGAGGACATGCCAGGGAGCCATCACGACAGCCAG
GTGTGCTCTAATGGGCCAGTTTCTGAGGACAGTGCTGCCGATGGAACCCCCAAGCATTCATTCAGGACTAGCTCCACTCTGGAAATAGAC
ACAGAGGAATTAACCTCTACGTCTTCAAGGACCTCACCTCCCAGAGGACGTCAGGATTCACTCAATGATTACTTAGATGCTATCGAACAC
AATGGCCACTCCAGGCCGGGGACAGCGACCTGCTCTGAGAGGTCCATGGGTGCCTCTCCGAAACTGAGGAGTAGTTTTCCCACTGACACA
AGACTCAATGCCATGCTTCATATTGATTCAGATGAAGAAGATCACGAGTTCCAGCAAGACCTGGGTTACCCATCTTCCTTGGAGGAGGAG
GGAGGCCTGATCATGTTTAGCAGGGCATCCAGAGCTGATGATGGAAGCCTGACATCTCAGACAAAGCTGGAGGACAACCCTGTTGAGAAT
GAGGAAGCCTCCACACACGAAGCTGCTTCCTTTGAGGATAAGCCAGAAAATCTTCCAGAGCTTGCAGAGAGCTCCTTACCTGCAGGCCCA
GCCCCAGAGGAAGGTGAAGGCGGCCCAGAGCCTCAACCCAGTGCTGACCAGGGCAGTGCTGAACTGTGTGGCTCTCAAGAGGTAGATCAG
CCCACAAGTGGCGCAGACACAGGGACTTCCGATGCATCAGGAGGAAGCCGAAGAGCCGTCAGTGAGACCGAGTCTCTCGATCAGGGCTCT
GAGCCTTCCCAGGTGTCCTCTGAAACAGAACCCAGTGATCCTGCCAGGACAGAGAGTGTGAGCGAAGCCAGCACCAGGCCTGAGGGAGAG
AGTGACCTGGAATGCGCTGACAGCTCCTGCAATGAGAGTGTGACCACGCAGCTGTCCTCTGTGGACACACGGTGCTCCTCTCTTGAGAGC
GCACGGTTTCCTGAAACCCCAGCCTTTTCTTCTCAGGAGGAGGAAGACGGAGCCTGTGCAGCAGAGCCCACCAGCAGTGGCCCTGCCGAA
GGGTCGCAGGAATCCGTGTGCACTGCTGGTTCTTTACCTGTGGTACAGGTGCCCAGTGGGGAGGATGAAGGGCCAGGGGCAGAATCGGCC
ACTGTACCTGACCAGGAGGAGCTGGGGGAGGTCTGGCAGCGGAGGGGGAGCCTGGAGGGAGCTGCAGCTGCTGCCGAGAGCCCACCGCAA
GAAGAAGGCAGTGCTGGGGAGGCCCAAGGCACCTGTGAAGGGGCAACTGCCCAGGAGGAGGGCGCTACTGGAGGTTCTCAAGCCAACGGC
CACCAGCCACTGCGATCACTACCTTCAGTGCGCCAGGATGTTAGCCGGTACCAGAGGGTGGACGAGGCTCTCCCACCAAACTGGGAGGCA
CGCATTGACAGCCACGGCAGGATCTTCTACGTGGATCACGTAAACAGAACCACGACGTGGCAGCGACCGACAGCTCCCCCAGCCCCGCAG
GTGCTGCAGAGATCTAACTCCATACAGCAAATGGAGCAGCTGAACCGGCGATATCAGAGTATCCGCAGAACCATGACCAATGAGAGGCCT
GAGGAAAATACCAATGCTATTGATGGGGCAGGGGAGGAAGCTGACTTTCACCAAGCCAGTGCAGATTTCCGACGGGAGAACATCCTGCCT
CACTCTACCTCCAGATCCAGGATCACGTTGCTGTTACAGTCTCCCCCCGTGAAGTTCCTCATCAGCCCAGAGTTCTTCACCGTGCTGCAT
TCTAACCCTAGTGCCTACCGCATGTTTACAAACAACACGTGTTTGAAGCACATGATCACCAAAGTCCGGAGGGACACCCACCACTTTGAA
CGCTACCAGCATAACCGCGACCTTGTGGGATTCCTCAACATGTTCGCGAACAAACAGCTAGAGCTGCCGCGGGGATGGGAAATGAAACAT
GATCACCAGGGCAAGGCATTCTTTGTGGACCACAACTCCCGCACCACCACTTTCATTGATCCCCGGCTCCCACTTCAGAGCAGTAGACCC
ACAAGTGCGCTGGTTCATCGGCAACACCTGACAAGGCAACGCAGCCACAGTGCGGGTGAGGTAGGAGAAGATTCTCGACATGCAGGACCA
CCAGTTCTTCCCAGGCCATCCAGTACATTCAATACAGTCAGTAGGCCACAGTACCAGGACATGGTTCCAGTGGCTTACAATGACAAGATT
GTTGCATTTCTACGTCAACCCAATATCTTTGAAATTCTACAGGAGCGTCAACCTGATCTTACCAGGAATCACTCACTCAGGGAGAAGATC
CAATTTATCCGAACTGAAGGGACTCCAGGATTGGTGCGCCTTTCAAGCGATGCAGACCTTGTTATGTTGCTGAGCTTATTTGAAGAAGAG
ATAATGTCGTATGTGCCTCCACATGCCTTACTCCACCCCAGCTACTGTCAGTCCCCACGTGGCTCTCCCGTGTCATCTCCTCAGAACTCG
CCAGGTACCCAGCGTGCCAATGCCCGGGCTCCAGCCCCTTACAAGCGGGATTTCGAAGCCAAACTGAGGAACTTTTACAGGAAGTTAGAG
ACTAAAGGATATGGACAAGGCCCAGGGAAGTTAAAGTTAATTATCCGAAGAGATCACTTACTAGAAGATGCTTTTAATCAGATTATGGGC
TACTCCAGAAAAGACCTGCAGAGAAATAAGCTATATGTCACCTTCGTTGGGGAGGAAGGGCTGGATTACAGTGGGCCTTCTAGAGAGTTT
TTCTTCCTGGTATCCAGAGAACTCTTTAACCCATATTATGGCTTATTTGAATATTCAGCCAATGACACATACACAGTACAAATAAGTCCT
ATGTCTGCTTTTGTAGACAATCACCATGAATGGTTCCGATTCAGTGGTAGGATCCTTGGTCTTGCACTAATACACCAGTATTTGTTGGAT
GCCTTCTTCACACGGCCCTTTTATAAGGCTCTTCTCAGAATTCTATGTGACCTGAGTGACCTAGAATACCTTGATGAAGAGTTCCATCAG
AGCCTGCAGTGGATGAAAGACAATGATATCCATGACATCCTAGACCTCACGTTCACTGTGAACGAAGAAGTATTTGGGCAGATAACTGAA
CGAGAATTAAAGCCAGGGGGTGCCAATATCCCAGTTACAGAGAAGAACAAGAAGGAGTACATCGAGAGGATGGTGAAGTGGAGGATTGAG
AGGGGTGTTGTACAGCAAACAGAGAGCTTAGTGCGTGGCTTCTATGAGGTGGTGGATGCCAGGCTGGTATCTGTTTTTGATGCAAGAGAA
CTGGAATTGGTCATCGCAGGCACAGCTGAAATAGACCTAAGTGATTGGAGAAACAACACAGAATATAGAGGAGGATACCATGACAATCAT
ATTGTAATTCGGTGGTTCTGGGCTGCAGTGGAAAGATTCAACAATGAACAACGACTAAGGTTGTTACAGTTTGTTACAGGCACATCCAGC
ATTCCCTATGAAGGATTTGCTTCACTCCGAGGGAGTAACGGCCCAAGAAGATTCTGTGTGGAGAAATGGGGGAAAATCACTGCTCTTCCC
AGAGCGCATACATGTTTTAACCGTCTGGATCTGCCTCCCTACCCATCCTTTTCCATGCTTTATGAAAAACTGTTGACAGCAGTTGAAGAA
ACCAGTACTTTTGGACTTGAGTGACCTGGAAGCTGAATGCCCATCTCTGTGGACAGGCAGGTTCAGAAGCTGCCTTCTAGAAGAATGATT
GAACATTGGAAGTTTCAAGAGGATGCTTCCTTTAGGATAAAGCTATGTGCTGTTGTTTTCCAGGAACAAGTGCTCTGTCACATTTGGGGA
CTGGAGATGAGTCCTCTTGGAAGGATTTGGGTGAGCTTGATGCCCAGGGAACAACCCAACCGTCTTTCAATCAACAGTTCTTGACTGCCA
AACTTTTTCCATTTGTTATGTTCCAAGACAAAGATGAACCCATACATGATCAGCTCCACGGTAATTTTTAGGGACTCAGGAGAATCTTGA
AACTTACCCTTGAACGTGGTTCAAGCCAAACTGGCAGCATTTGGCCCAATCTCCAAATTAGAGCAAGTTAAATAATATAATAAAAGTAAA
TATATTTCCTGAAAGTACATTCATTTAAGCCCTAAGTTATAACAGAATATTCATTTCTTGCTTATGAGTGCCTGCATGGTGTGCACCATA
GGTTTCCGCTTTCATGGGACATGAGTGAAAATGAAACCAAGTCAATATGAGGTACCTTTACAGATTTGCAATAAGATGGTCTGTGACAAT
GTATATGCAAGTGGTATGTGTGTAATTATGGCTAAAGACAAACCATTATTCAGTGAATTACTAATGACAGATTTTATGCTTTATAATGCA
TGAAAACAATTTTAAAATAACTAGCAATTAATCACAGCATATCAGGAAAAAGTACACAGTGAGTTCTGTTTATTTTTTGTAGGTTCATTA
TGTTTATGTTCTTTAAGATGTATATAAGAACCTACCTATCATGCTGTATGTATCACTCATTCCATTTTCATGTTCCATGCATACTCGGGC
ATCATGCTAATATGTATCCTTTTAAGCACTCTCAAGGAAACAAAAGGGCCTTTTATTTTTATAAAGGTAAAAAAAATTCCCCAAATATTT
TGCACTGAATGTACCAAAGGTGAAGGGACATTACAATATGACTAACAGCAACTCCATCACTTGAGAAGTATAATAGAAAATAGCTTCTAA
ATCAAACTTCCTTCACAGTGCCGTGTCTACCACTACAAGGACTGTGCATCTAAGTAATAATTTTTTAAGATTCACTATATGTGATAGTAT
GATATGCATTTATTTAAAATGCATTAGACTCTCTTCCATCCATCAAATACTTTACAGGATGGCATTTAATACAGATATTTCGTATTTCCC
CCACTGCTTTTTATTTGTACAGCATCATTAAACACTAAGCTCAGTTAAGGAGCCATCAGCAACACTGAAGAGATCAGTAGTAAGAATTCC
ATTTTCCCTCATCAGTGAAGACACCACAAATTGAAACTCAGAACTATATTTCTAAGCCTGCATTTTCACTGATGCATAATTTTCTTATTA
ATATTAAGAGACAGTTTTTCTATGGCATCTCCAAAACTGCATGACATCACTAGTCTTACTTCTGCTTAATTTTATGAGAAGGTATTCTTC
ATTTTAATTGCTTTTGGGATTACTCCACATCTTTGTTTATTTCTTGACTAATCAGATTTTCAATAGAGTGAAGTTAAATTGGGGGTCATA
AAAGCATTGGATTGACATATGGTTTGCCAGCCTATGGGTTTACAGGCATTGCCCAAACATTTCTTTGAGATCTATATTTATAAGCAGCCA
TGGAATTCCTATTATGGGATGTTGGCAATCTTACATTTTATAGAGGTCATATGCATAGTTTTCATAGGTGTTTTGTAAGAACTGATTGCT
CTCCTGTGAGTTAAGCTATGTTTACTACTGGGACCCTCAAGAGGAATACCACTTATGTTACACTCCTGCACTAAAGGCACGTACTGCAGT
GTGAAGAAATGTTCTGAAAAAGGGTTATAGAAATCTGGAAATAAGAAAGGAAGAGCTCTCTGTATTCTATAATTGGAAGAGAAAAAAAGA
AAAACTTTTAACTGGAAATGTTAGTTTGTACTTATTGATCATGAATACAAGTATATATTTAATTTTGCAAACTTTTCACTTGTTTGTATT
CTTTTCATTATAAGGAAAAGTAGTATAACACACTTTTTTTTAAGTCACATATTTGATGGTATACAAGATGTTTCAGGGCTGGCATTCTCC
AAGCAGCAGATAAAGGTTGCATTTCTTTCAAAAATACATTCAAAGACCATGTTATCCTTCATTTTGGTTTGAGACATTTAGTTATGGTAT
TTCATATTATTAGGTAAAAGATATTTGAAATAAAATGTATCTCTTTAATTATTTCTAACAAATATATTTCTTTATTAAGGCATCCAACTT
TTTCCCAAATAACAGTACACTTTAATGTATGTAGACATTCTTAATTAGTATAATCATCTAGTTGATACTGTTCTCAGATTGGGAATTATC
AAAGATGTACTTATCATATCAGAACACCATGCTAACTTATCTATTATTCTTTCTTAGTAAAACAAAACAGCCAGTAATAACTATATAAAA
TATTAAATAACATTTCCACAGAATAAATTAGACTTTCATGTACTCTACAATTAGAAATATCCATAAATATTTTCTTCTGGACTGTGAACC
CAGATAACTAGGCTTTCTGGTCTTATTTTAAGTGATGCTCTTTATACTATAGAAGACACTCTTAATACATCATATATGTATGCAGAACAT
CTCTTAGATGAGAGAACAAGCACATCATTGGCATTCCCTCTGTGCCAGTTTGATGTTTGTTTGACGATGGAGCTACAAGAGTCTAAATCT
GCCTTTGAAAAGCTCAGCTCACAGTGTAGTAGAGTAGACTCCAAGGTTCAAAAAAGTGTTTTTAATAAAATTTGGTAAGTTCTACAATCA
AGGAATGAAGAGAGAAGAGAACAGCTTTTTCCATCTGGGAGATTCAATAATGGCTTCATATATAGATGATAGTGTGGCTAAAAAAAATTA
CATCAATGCTGTTTCTATTGGGAAGCAATGGCAAGTAATAGTATGTCAATACTGGTCAAGTGTTGAAGCCAGGATGCACTTACACAACGA
GAGTGTAAAGTGTGTAGGGAGCTGATCTGTGAAGGAGCAACTCAAAGATTTTGAAATTATCAGTGAAATGCCAAAACAGGGAAAGTTTCC
CTGTTTCCCTTCATCTATTCTACAATGCACCATTGGTTTTCAGTGTGAAAAATCCCAATCCCTGAGCCCAAACCACTTCTGGGGTCAAAA
CATTTTTCTTGTGCACAAAATGAATGGATCTTGGTCAAAGAAGTATGGTCACAATTTTCTAGCATATATTGCGTTTATAATTTAGCAGAA
ATTCTGCAATAAATAAAGGAAAATCTGTTTTACCTGTGCAACAATCAGAAATGGTAAAAATGCATTCAAGTGTTTGAAAGAAATGGTAGA
ATATGCTTGCATAGTGCTTTATAGTTTCAAAGTGCTGTCAGGTACATCGTCCGTTTAGCTCCTCACGCACTTTGTAGGGTACAAGCATCA
TGTTCCATCTGGGTTGTGGCTGATTTTCATGGATGGCTTGTGGCATCAGTTTCATTACTTCATAGTCACAATTCTGTGTTTCATCTTGAG
AAATGTGGAGACTAATGTTTGTACCAGTATATTCCACATTCAGTGAGGTTTCCAAGATGCTTCCTCCAAACTCTCACTTTCTTAAACAGA
TACATTTAAAATATGACACCTTCTGAAAAGTCCATAAAGAAATTAGTATATTCATGGAAAAAATTTCCCCGTAGACTTATTTGCATTTCA
TGACTTGACATGAGAAATTTAAAAAACAGAAGGCAAAATGTGATTGCTTTTGATGGATTTATACAGAATAGTCATTTAATTTTCTCAAGT
ATTATTTGGAAACAAGATAATGGAAAACATTAATCAGAAGCCTTATTTTATTTTTAAATTTTTAATAGGGATGGATCTAGTAAGCCCTAA
TAGCTGAGTTCCAGTGATAAAATTCACAAATTTTATTTATGATTGGACCACTTCTAACAAGGCAAATATCTTATAATGAAGATAGGAGTC
TGTTCAATTTAACCTTATTCAGGAAACTCCGTATTTATGTGAAATGATGCAATGCCATTATTAAGAGGTATCTGTAACCCTGCATAATAA
AAACATGCATAAGAAGAATGTGGTCTAATCTCCAAACTGAGTCTCAGTTTCAGGGCCTTTTGCTTTCTTTGTTTGTTTGTTTGAGACAGT
CTGGCTCTGTCATCCAGGCTGGAGTGCAGTGGCACATGAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCC
TCCTGAGTAACTGGGACTACAGGCGCATACCACCACACCTGGCTAATTTTTGTATTTTTGTAGAGACAAGGCCCAGGCACGTCTCAAACT
CTTGAGCTCAAGCGATCCGCCCGCCTTGGCCTCCCAAAGTGCTAGGAGTAATTATAGGTGTGAGCCACCATGCTGGCAGTTGTTTTTGTT
TATTTGTGATAAGGTCTGGCTGTCACCCATGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGGCTCAAGCCA
GCCTCCCACCTCAGCCTCCGAGTAGCTAGGACTACAGGCATGCACCACCATGCCCAGCTAATTTTTTTATATTTTTTGTAGACACAGGGT
TTTGCCACGTTGCCCAGGCTGGTCTTGAACTCCTGAGCTCAAGCAGTCCTCCCACCTTGGCCTCCCGAAGTGCTGGGATTACAGACGTGA
GCCTCTGGGCCTTGCTCTGTTTTGTCTGCTTTCTGATTTAGTAGGTGAGGGACAGCACTCTGGACCTTAGCCATTTTACTTCCATCTTAC
TGCCGTGAGTTTGATGAGAATGTCACTTTTAGACTCTAATTTTCAAAAACTTAGTTTCTTTCCCATTCATTTGTGTTTTCCAAATTAATT
TGTTTGTCTAGTATGGATGCAAAGGAATGCTGAAGACATTAAAGCTTTCTGAATTGTGGCTTAAGGCCAGCTACTGCCCACTGAAAGGAT
GATAAAAATAAAAAAGGAGGAAAGAGGAGCCCAGCAGTTGTGCCACCCCGCAAGAATATAATGCTAATTATTGACCAACTGTCAAGATTC
AGAGTGGTAACTGCATTCCGAGGAGCTGTCAGGAAGGATGACCGTGTGTGTGCTGTCCATATCATAGCCATCTGGGTCAGAAGGAGCGAA
AGGATGGTTAGGACAGGAGTGTAGTGGAGGGAAAGTTAAAACAACGGTAGATGGATCATCTTAGGGCTTGCTGGTGGGGGTAGGAACATA
CTTCAATTTGGTTTCAGACTGAGAAGAAGAAAGCTATGCTCCCTGATGAAGGCACAGTTTGATCTACTAGATGGGAAATACCCTCATTTT
ATAACTTCAGTAATTTAACATTTTCTGTATTGCAAAGTGGAATTTAGTCCCAAAGTATTAAAGCTAACCATAGCTTGATCAGGAGATTTG
ACAATTTAGCATAAAATTATGTTGTGGATTTTTTTATTTAAGAATTATTGTTACTATTATTGAACACCATGTATGAAATGAAAGAAAGGG
TGCTTTTATTTCATTATACTTATTTGGTTTTTTTAGCGGACATCCCTTGACATTAGAATAGCATTTGAGACATTTTCATGATTTCTAAAG
ATAACTTAAATGCTCTCTGTTAATCTGGAAAGTGAAATCCTAAGAGTGAGGTTGCAAATGGAGACTAAATTAGTGTTTCCAAGTCAGGAA
GTTAATCAAGACCGGAAATAGATTTGCTTAGATTTTATCTGCAGAGTCGTTTATTTGGCTTTCGTAATTGAACAGCTCAGCAGAATAAGA
TGGCCCTAGTTGTATGGTTTCTGGGGAACACAGGAGAATTAAATTTATATATGTGATTTTTATGTGTAGTGCCCTTGGGCAGGTGATATC
TTTCTATATGACTTTTAAGATATTACAACCTGAGGAGTGTGGATAGCCGTGTTGTGTGATTCAAACTGAATCAGCTATTACTGATGCAGG
TAAGGAACCATCAGTCAACTTCTGGTTACTATCACCTTCATAAAAAAGAATGGATGATGTTCAGGAATTACCTTGGAAGGATTAACCAGG
AATTAACACAGAATGGGATGTTCTTTTAGGACCCTAATGCTCTAAAAGATAAAATTACAACCTATTTTTCTTTATATGATAGCATAAGTA
AAATTTGGGGCTGTTAATATGTTGGAAAGTGCTTAAAATTACATGTTTTTATAATAGGGATGCAGGCATTCCAAAATAAATGAATAAAAA
TACATGCATCTCTCTCGCCTCTTACTGAAAGTATTAATCTAATTTTATAGTAATGATTACTTTTTAATATTAAGGCTCTGTAAAAAAATT
ATTTCTAAGATTTCAGTAGAACACAGGTGGTGTATTTTTTTAAGCTTTTAATTTCTCTTCACCAACCTCAGTCATTACGTTCACCACACA
GTGTGTCACAGTTAATAGTGGTATTTCAGTTTTTGCGTTGATTTAAGCTTCATATTTATTTAATGTGACTTTTGATGGAGAATAATAATG
GGAGATGCTTGCTGTTAGCATTAAGGTTATACAGCTCTCACTTCACCTTATATGTAATTTTTTTTTCAAAGTAAATAATGCAGATTGTTG
ACATCCTAGAAATGGTTTCTGGGTGGTATTATATGGGGCCTAGGACTCTGAACTGGGACTAGTTGTTTATTTTCTGGGAAGTCTGTATTC
TTATTCTCAACTGAACCCCTGACTCTTTTGTTGTATTTTTTATGATTCCGAAATGCTTTGAGGGAAAGATATTTTAATGTGTACAATTTG
TTTTATTTTCATACTGATCTCTATTTTTGTTTAAAACCATGTTGCATCATGAAATCACTTAATCCAAAATAAATCTTCTTTAAAAAAAAT

>49730_49730_1_LRP1B-HECW2_LRP1B_chr2_142567848_ENST00000389484_HECW2_chr2_197208488_ENST00000260983_length(amino acids)=1580AA_BP=106
MTPLDSRLQAAPAAAAAAGPKVPPSSLQRRLPYRATTMSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCD
GDPDCPDDSDESLDTYENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAVMMGAEGME
GGASGNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIE
IKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTILGVNSVNGDLGSPS
DDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMG
ASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAASFEDKPEN
LPELAESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPART
ESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQV
PSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRY
QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFH
QASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN
KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQ
YQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQ
SPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG
EEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCD
LSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEV
VDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRR

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Fusion Gene PPI Analysis for LRP1B-HECW2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	HECW2	chr2:142567848	chr2:197208488	ENST00000260983		1	29	737_1068	97.33333333333333	1573.0	TP73
Tgene	HECW2	chr2:142567848	chr2:197208488	ENST00000409111		0	27	737_1068	0	1217.0	TP73

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LRP1B-HECW2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LRP1B-HECW2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source