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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:LRP1-CAND1 (FusionGDB2 ID:49739)

Fusion Gene Summary for LRP1-CAND1

Fusion gene summary

Fusion gene information	Fusion gene name: LRP1-CAND1
	Fusion gene ID: 49739
		Hgene	Tgene
	Gene symbol	LRP1	CAND1
	Gene ID	10438	55832
	Gene name	C1D nuclear receptor corepressor	cullin associated and neddylation dissociated 1
	Synonyms	LRP1\|Rrp47\|SUN-CoR\|SUNCOR\|hC1D	TIP120\|TIP120A
	Cytomap	2p14	12q14.3-q15
	Type of gene	protein-coding	protein-coding
	Description	nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor	cullin-associated NEDD8-dissociated protein 1TBP-interacting protein of 120 kDa Ap120 CAND1
	Modification date	20200313	20200327
	UniProtAcc	Q07954	Q86VP6
	Ensembl transtripts involved in fusion gene	ENST00000243077, ENST00000338962, ENST00000553277, ENST00000553446, ENST00000554174,	ENST00000539109, ENST00000545606,
Fusion gene scores	* DoF score	23 X 27 X 12=7452	5 X 7 X 4=140
	# samples	26	6
	** MAII score	log2(26/7452*10)=-4.84104414591318 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/140*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LRP1 [Title/Abstract] AND CAND1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LRP1(57596320)-CAND1(67686402), # samples:3
Anticipated loss of major functional domain due to fusion event.	LRP1-CAND1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CAND1	GO:0010265	SCF complex assembly	15537541\|21249194
Tgene	CAND1	GO:0016567	protein ubiquitination	12609982\|15537541\|21249194
Tgene	CAND1	GO:0030154	cell differentiation	10581176
Tgene	CAND1	GO:0043086	negative regulation of catalytic activity	12609982

Fusion gene breakpoints across LRP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CAND1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A3U6-01A	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
ChimerDB4	SARC	TCGA-DX-A3U6-01A	LRP1	chr12	57596320	-	CAND1	chr12	67686402	+
ChimerDB4	SARC	TCGA-DX-A3U6-01A	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
ChimerDB4	SARC	TCGA-DX-A3U6-01A	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
ChimerDB4	SARC	TCGA-DX-A3U6-01A	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
ChimerDB4	SARC	TCGA-DX-A3U6	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+

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Fusion Gene ORF analysis for LRP1-CAND1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000243077	ENST00000539109	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
5CDS-intron	ENST00000243077	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
5CDS-intron	ENST00000243077	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
5CDS-intron	ENST00000243077	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
Frame-shift	ENST00000243077	ENST00000545606	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
Frame-shift	ENST00000243077	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
Frame-shift	ENST00000243077	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
In-frame	ENST00000243077	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-3CDS	ENST00000338962	ENST00000545606	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-3CDS	ENST00000338962	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-3CDS	ENST00000338962	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-3CDS	ENST00000338962	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-3CDS	ENST00000553277	ENST00000545606	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-3CDS	ENST00000553277	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-3CDS	ENST00000553277	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-3CDS	ENST00000553277	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-3CDS	ENST00000553446	ENST00000545606	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-3CDS	ENST00000553446	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-3CDS	ENST00000553446	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-3CDS	ENST00000553446	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-3CDS	ENST00000554174	ENST00000545606	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-3CDS	ENST00000554174	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-3CDS	ENST00000554174	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-3CDS	ENST00000554174	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-intron	ENST00000243077	ENST00000539109	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000243077	ENST00000545606	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000338962	ENST00000539109	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-intron	ENST00000338962	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-intron	ENST00000338962	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-intron	ENST00000338962	ENST00000539109	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000338962	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-intron	ENST00000338962	ENST00000545606	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000553277	ENST00000539109	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-intron	ENST00000553277	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-intron	ENST00000553277	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-intron	ENST00000553277	ENST00000539109	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000553277	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-intron	ENST00000553277	ENST00000545606	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000553446	ENST00000539109	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-intron	ENST00000553446	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-intron	ENST00000553446	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-intron	ENST00000553446	ENST00000539109	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000553446	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-intron	ENST00000553446	ENST00000545606	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000554174	ENST00000539109	LRP1	chr12	57596319	+	CAND1	chr12	67686401	+
intron-intron	ENST00000554174	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686402	+
intron-intron	ENST00000554174	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+
intron-intron	ENST00000554174	ENST00000539109	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+
intron-intron	ENST00000554174	ENST00000539109	LRP1	chr12	57596320	+	CAND1	chr12	67686401	+
intron-intron	ENST00000554174	ENST00000545606	LRP1	chr12	57596792	+	CAND1	chr12	67680694	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000243077

LRP1

chr12

57596320

ENST00000545606

CAND1

chr12

67688813

21624

11177

442

14502

4686

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000243077	ENST00000545606	LRP1	chr12	57596320	+	CAND1	chr12	67688813	+	0.000513996	0.99948597

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Fusion Genomic Features for LRP1-CAND1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LRP1	chr12	57596320	+	CAND1	chr12	67686401	+	0.006557902	0.99344206
LRP1	chr12	57596320	+	CAND1	chr12	67686401	+	0.006557902	0.99344206
LRP1	chr12	57596320	+	CAND1	chr12	67688812	+	0.001365901	0.99863404
LRP1	chr12	57596320	+	CAND1	chr12	67686401	+	0.006557902	0.99344206
LRP1	chr12	57596320	+	CAND1	chr12	67686401	+	0.006557902	0.99344206
LRP1	chr12	57596320	+	CAND1	chr12	67688812	+	0.001365901	0.99863404

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRP1-CAND1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57596320/chr12:67686402)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP1 Q07954	CAND1 Q86VP6
FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). {ECO:0000250\|UniProtKB:Q91ZX7, ECO:0000269\|PubMed:11907044, ECO:0000269\|PubMed:12713657, ECO:0000269\|PubMed:12888553, ECO:0000269\|PubMed:1702392, ECO:0000269\|PubMed:26142438, ECO:0000269\|PubMed:32296178}.; FUNCTION: (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269\|PubMed:1618748}.	FUNCTION: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269\|PubMed:12504025, ECO:0000269\|PubMed:12504026, ECO:0000269\|PubMed:12609982, ECO:0000269\|PubMed:16449638, ECO:0000269\|PubMed:21249194, ECO:0000269\|PubMed:23453757}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1013_1053

3570

4545.0

Domain

LDL-receptor class A 7

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1060_1099

3570

4545.0

Domain

LDL-receptor class A 8

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1102_1142

3570

4545.0

Domain

LDL-receptor class A 9

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

111_149

3570

4545.0

Domain

EGF-like 1

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1143_1182

3570

4545.0

Domain

LDL-receptor class A 10

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1183_1222

3570

4545.0

Domain

EGF-like 5

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1223_1262

3570

4545.0

Domain

EGF-like 6

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

150_189

3570

4545.0

Domain

EGF-like 2%3B calcium-binding

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1536_1579

3570

4545.0

Domain

EGF-like 7

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1846_1887

3570

4545.0

Domain

EGF-like 8

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2155_2195

3570

4545.0

Domain

EGF-like 9

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2478_2518

3570

4545.0

Domain

EGF-like 10

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2522_2563

3570

4545.0

Domain

LDL-receptor class A 11

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2564_2602

3570

4545.0

Domain

LDL-receptor class A 12

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

25_66

3570

4545.0

Domain

LDL-receptor class A 1

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2603_2641

3570

4545.0

Domain

LDL-receptor class A 13

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2642_2690

3570

4545.0

Domain

LDL-receptor class A 14

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2694_2732

3570

4545.0

Domain

LDL-receptor class A 15

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2732_2771

3570

4545.0

Domain

LDL-receptor class A 16

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2772_2814

3570

4545.0

Domain

LDL-receptor class A 17

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2816_2855

3570

4545.0

Domain

LDL-receptor class A 18

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2856_2899

3570

4545.0

Domain

LDL-receptor class A 19

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2902_2940

3570

4545.0

Domain

LDL-receptor class A 20

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2941_2981

3570

4545.0

Domain

EGF-like 11

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2982_3022

3570

4545.0

Domain

EGF-like 12%3B calcium-binding

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3290_3331

3570

4545.0

Domain

EGF-like 13

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3332_3371

3570

4545.0

Domain

LDL-receptor class A 21

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3372_3410

3570

4545.0

Domain

LDL-receptor class A 22

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3411_3450

3570

4545.0

Domain

LDL-receptor class A 23

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3451_3491

3570

4545.0

Domain

LDL-receptor class A 24

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3492_3533

3570

4545.0

Domain

LDL-receptor class A 25

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3534_3572

3570

4545.0

Domain

LDL-receptor class A 26

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

474_520

3570

4545.0

Domain

EGF-like 3

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

70_110

3570

4545.0

Domain

LDL-receptor class A 2

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

803_843

3570

4545.0

Domain

EGF-like 4

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

852_892

3570

4545.0

Domain

LDL-receptor class A 3

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

893_933

3570

4545.0

Domain

LDL-receptor class A 4

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

934_973

3570

4545.0

Domain

LDL-receptor class A 5

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

974_1013

3570

4545.0

Domain

LDL-receptor class A 6

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1309_1355

3570

4545.0

Repeat

Note=LDL-receptor class B 8

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1356_1398

3570

4545.0

Repeat

Note=LDL-receptor class B 9

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1399_1445

3570

4545.0

Repeat

Note=LDL-receptor class B 10

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1446_1490

3570

4545.0

Repeat

Note=LDL-receptor class B 11

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1491_1531

3570

4545.0

Repeat

Note=LDL-receptor class B 12

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1627_1669

3570

4545.0

Repeat

Note=LDL-receptor class B 13

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1670_1713

3570

4545.0

Repeat

Note=LDL-receptor class B 14

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1714_1753

3570

4545.0

Repeat

Note=LDL-receptor class B 15

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1754_1798

3570

4545.0

Repeat

Note=LDL-receptor class B 16

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1934_1976

3570

4545.0

Repeat

Note=LDL-receptor class B 17

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

1977_2019

3570

4545.0

Repeat

Note=LDL-receptor class B 18

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2020_2063

3570

4545.0

Repeat

Note=LDL-receptor class B 19

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2064_2107

3570

4545.0

Repeat

Note=LDL-receptor class B 20

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2253_2294

3570

4545.0

Repeat

Note=LDL-receptor class B 21

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2295_2343

3570

4545.0

Repeat

Note=LDL-receptor class B 22

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2344_2388

3570

4545.0

Repeat

Note=LDL-receptor class B 23

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2389_2431

3570

4545.0

Repeat

Note=LDL-receptor class B 24

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

2432_2473

3570

4545.0

Repeat

Note=LDL-receptor class B 25

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

292_334

3570

4545.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3069_3113

3570

4545.0

Repeat

Note=LDL-receptor class B 26

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3114_3156

3570

4545.0

Repeat

Note=LDL-receptor class B 27

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3157_3200

3570

4545.0

Repeat

Note=LDL-receptor class B 28

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3201_3243

3570

4545.0

Repeat

Note=LDL-receptor class B 29

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3244_3284

3570

4545.0

Repeat

Note=LDL-receptor class B 30

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

335_378

3570

4545.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

379_422

3570

4545.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

571_613

3570

4545.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

614_659

3570

4545.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

660_710

3570

4545.0

Repeat

Note=LDL-receptor class B 6

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

711_754

3570

4545.0

Repeat

Note=LDL-receptor class B 7

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

314_344

122

1231.0

Compositional bias

Note=Asp-rich

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

1002_1039

122

1231.0

Repeat

Note=HEAT 24

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

1043_1097

122

1231.0

Repeat

Note=HEAT 25

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

1099_1133

122

1231.0

Repeat

Note=HEAT 26

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

1140_1189

122

1231.0

Repeat

Note=HEAT 27

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

131_165

122

1231.0

Repeat

Note=HEAT 4

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

171_208

122

1231.0

Repeat

Note=HEAT 5

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

210_247

122

1231.0

Repeat

Note=HEAT 6

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

248_282

122

1231.0

Repeat

Note=HEAT 7

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

289_366

122

1231.0

Repeat

Note=HEAT 8

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

370_407

122

1231.0

Repeat

Note=HEAT 9

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

424_467

122

1231.0

Repeat

Note=HEAT 10

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

471_510

122

1231.0

Repeat

Note=HEAT 11

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

515_552

122

1231.0

Repeat

Note=HEAT 12

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

563_602

122

1231.0

Repeat

Note=HEAT 13

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

606_643

122

1231.0

Repeat

Note=HEAT 14

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

646_683

122

1231.0

Repeat

Note=HEAT 15

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

688_725

122

1231.0

Repeat

Note=HEAT 16

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

729_768

122

1231.0

Repeat

Note=HEAT 17

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

770_808

122

1231.0

Repeat

Note=HEAT 18

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

809_845

122

1231.0

Repeat

Note=HEAT 19

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

852_889

122

1231.0

Repeat

Note=HEAT 20

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

890_927

122

1231.0

Repeat

Note=HEAT 21

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

928_960

122

1231.0

Repeat

Note=HEAT 22

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

961_998

122

1231.0

Repeat

Note=HEAT 23

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3573_3611

3570

4545.0

Domain

LDL-receptor class A 27

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3611_3649

3570

4545.0

Domain

LDL-receptor class A 28

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3652_3692

3570

4545.0

Domain

LDL-receptor class A 29

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3693_3733

3570

4545.0

Domain

LDL-receptor class A 30

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3739_3778

3570

4545.0

Domain

LDL-receptor class A 31

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3781_3823

3570

4545.0

Domain

EGF-like 14

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3824_3861

3570

4545.0

Domain

EGF-like 15

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4147_4183

3570

4545.0

Domain

EGF-like 16

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4196_4232

3570

4545.0

Domain

EGF-like 17

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4232_4268

3570

4545.0

Domain

EGF-like 18

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4268_4304

3570

4545.0

Domain

EGF-like 19

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4304_4340

3570

4545.0

Domain

EGF-like 20

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4340_4375

3570

4545.0

Domain

EGF-like 21

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4373_4409

3570

4545.0

Domain

EGF-like 22

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3940_3943

3570

4545.0

Motif

Recognition site for proteolytical processing

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4502_4507

3570

4545.0

Motif

Note=NPXY motif

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3912_3954

3570

4545.0

Repeat

Note=LDL-receptor class B 31

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

3970_4012

3570

4545.0

Repeat

Note=LDL-receptor class B 32

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4013_4056

3570

4545.0

Repeat

Note=LDL-receptor class B 33

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4057_4101

3570

4545.0

Repeat

Note=LDL-receptor class B 34

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

20_4419

3570

4545.0

Topological domain

Extracellular

Hgene

LRP1

chr12:57596320

chr12:67688813

ENST00000243077

4420_4444

3570

4545.0

Transmembrane

Helical

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

2_39

122

1231.0

Repeat

Note=HEAT 1

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

44_81

122

1231.0

Repeat

Note=HEAT 2

Tgene

CAND1

chr12:57596320

chr12:67688813

ENST00000545606

83_119

122

1231.0

Repeat

Note=HEAT 3

Top

Fusion Gene Sequence for LRP1-CAND1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>49739_49739_1_LRP1-CAND1_LRP1_chr12_57596320_ENST00000243077_CAND1_chr12_67688813_ENST00000545606_length(transcript)=21624nt_BP=11177nt
CAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGCTCCCCT
ACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCTGTGAGC
TTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGT
CAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAG
GAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCT
TGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAA
GACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGA
CGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTG
TGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTG
CTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGG
CAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTG
TGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAA
CTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTT
CAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAA
GGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACGTGGAACAGATGGCCATCGACTGGCTGACAGGCAACTTCTA
CTTTGTGGATGACATCGATGATAGGATCTTTGTCTGCAACAGAAATGGGGACACATGTGTCACATTGCTAGACCTGGAACTCTACAACCC
CAAGGGCATTGCCCTGGACCCTGCCATGGGGAAGGTGTTTTTCACTGACTATGGGCAGATCCCAAAGGTGGAACGCTGTGACATGGATGG
GCAGAACCGCACCAAGCTCGTCGACAGCAAGATTGTGTTTCCTCATGGCATCACGCTGGACCTGGTCAGCCGCCTTGTCTACTGGGCAGA
TGCCTATCTGGACTATATTGAAGTGGTGGACTATGAGGGCAAGGGCCGCCAGACCATCATCCAGGGCATCCTGATTGAGCACCTGTACGG
CCTGACTGTGTTTGAGAATTATCTCTATGCCACCAACTCGGACAATGCCAATGCCCAGCAGAAGACGAGTGTGATCCGTGTGAACCGCTT
TAACAGCACCGAGTACCAGGTTGTCACCCGGGTGGACAAGGGTGGTGCCCTCCACATCTACCACCAGAGGCGTCAGCCCCGAGTGAGGAG
CCATGCCTGTGAAAACGACCAGTATGGGAAGCCGGGTGGCTGCTCTGACATCTGCCTGCTGGCCAACAGCCACAAGGCGCGGACCTGCCG
CTGCCGTTCCGGCTTCAGCCTGGGCAGTGACGGGAAGTCATGCAAGAAGCCGGAGCATGAGCTGTTCCTCGTGTATGGCAAGGGCCGGCC
AGGCATCATCCGGGGCATGGATATGGGGGCCAAGGTCCCGGATGAGCACATGATCCCCATTGAAAACCTCATGAACCCCCGAGCCCTGGA
CTTCCACGCTGAGACCGGCTTCATCTACTTTGCCGACACCACCAGCTACCTCATTGGCCGCCAGAAGATTGATGGCACTGAGCGGGAGAC
CATCCTGAAGGACGGCATCCACAATGTGGAGGGTGTGGCCGTGGACTGGATGGGAGACAATCTGTACTGGACGGACGATGGGCCCAAAAA
GACAATCAGCGTGGCCAGGCTGGAGAAAGCTGCTCAGACCCGCAAGACTTTAATCGAGGGCAAAATGACACACCCCAGGGCTATTGTGGT
GGATCCACTCAATGGGTGGATGTACTGGACAGACTGGGAGGAGGACCCCAAGGACAGTCGGCGTGGGCGGCTGGAGAGGGCGTGGATGGA
TGGCTCACACCGAGACATCTTTGTCACCTCCAAGACAGTGCTTTGGCCCAATGGGCTAAGCCTGGACATCCCGGCTGGGCGCCTCTACTG
GGTGGATGCCTTCTACGACCGCATCGAGACGATACTGCTCAATGGCACAGACCGGAAGATTGTGTATGAAGGTCCTGAGCTGAACCACGC
CTTTGGCCTGTGTCACCATGGCAACTACCTCTTCTGGACTGAGTATCGGAGTGGCAGTGTCTACCGCTTGGAACGGGGTGTAGGAGGCGC
ACCCCCCACTGTGACCCTTCTGCGCAGTGAGCGGCCCCCCATCTTTGAGATCCGAATGTATGATGCCCAGCAGCAGCAAGTTGGCACCAA
CAAATGCCGGGTGAACAATGGCGGCTGCAGCAGCCTGTGCTTGGCCACCCCTGGGAGCCGCCAGTGCGCCTGTGCTGAGGACCAGGTGTT
GGACGCAGACGGCGTCACTTGCTTGGCGAACCCATCCTACGTGCCTCCACCCCAGTGCCAGCCAGGCGAGTTTGCCTGTGCCAACAGCCG
CTGCATCCAGGAGCGCTGGAAGTGTGACGGAGACAACGATTGCCTGGACAACAGTGATGAGGCCCCAGCCCTCTGCCATCAGCACACCTG
CCCCTCGGACCGATTCAAGTGCGAGAACAACCGGTGCATCCCCAACCGCTGGCTCTGCGACGGGGACAATGACTGTGGGAACAGTGAAGA
TGAGTCCAATGCCACTTGTTCAGCCCGCACCTGCCCCCCCAACCAGTTCTCCTGTGCCAGTGGCCGCTGCATCCCCATCTCCTGGACGTG
TGATCTGGATGACGACTGTGGGGACCGCTCTGATGAGTCTGCTTCGTGTGCCTATCCCACCTGCTTCCCCCTGACTCAGTTTACCTGCAA
CAATGGCAGATGTATCAACATCAACTGGAGATGCGACAATGACAATGACTGTGGGGACAACAGTGACGAAGCCGGCTGCAGCCACTCCTG
TTCTAGCACCCAGTTCAAGTGCAACAGCGGGCGTTGCATCCCCGAGCACTGGACCTGCGATGGGGACAATGACTGCGGAGACTACAGTGA
TGAGACACACGCCAACTGCACCAACCAGGCCACGAGGCCCCCTGGTGGCTGCCACACTGATGAGTTCCAGTGCCGGCTGGATGGACTATG
CATCCCCCTGCGGTGGCGCTGCGATGGGGACACTGACTGCATGGACTCCAGCGATGAGAAGAGCTGTGAGGGAGTGACCCACGTCTGCGA
TCCCAGTGTCAAGTTTGGCTGCAAGGACTCAGCTCGGTGCATCAGCAAAGCGTGGGTGTGTGATGGCGACAATGACTGTGAGGATAACTC
GGACGAGGAGAACTGCGAGTCCCTGGCCTGCAGGCCACCCTCGCACCCTTGTGCCAACAACACCTCAGTCTGCCTGCCCCCTGACAAGCT
GTGTGATGGCAACGACGACTGTGGCGACGGCTCAGATGAGGGCGAGCTCTGCGACCAGTGCTCTCTGAATAACGGTGGCTGCAGCCACAA
CTGCTCAGTGGCACCTGGCGAAGGCATTGTGTGTTCCTGCCCTCTGGGCATGGAGCTGGGGCCCGACAACCACACCTGCCAGATCCAGAG
CTACTGTGCCAAGCATCTCAAATGCAGCCAAAAGTGCGACCAGAACAAGTTCAGCGTGAAGTGCTCCTGCTACGAGGGCTGGGTCCTGGA
ACCTGACGGCGAGAGCTGCCGCAGCCTGGACCCCTTCAAGCCGTTCATCATTTTCTCCAACCGCCATGAAATCCGGCGCATCGATCTTCA
CAAAGGAGACTACAGCGTCCTGGTGCCCGGCCTGCGCAACACCATCGCCCTGGACTTCCACCTCAGCCAGAGCGCCCTCTACTGGACCGA
CGTGGTGGAGGACAAGATCTACCGCGGGAAGCTGCTGGACAACGGAGCCCTGACTAGTTTCGAGGTGGTGATTCAGTATGGCCTGGCCAC
ACCCGAGGGCCTGGCTGTAGACTGGATTGCAGGCAACATCTACTGGGTGGAGAGTAACCTGGATCAGATCGAGGTGGCCAAGCTGGATGG
GACCCTCCGGACCACCCTGCTGGCCGGTGACATTGAGCACCCAAGGGCAATCGCACTGGATCCCCGGGATGGGATCCTGTTTTGGACAGA
CTGGGATGCCAGCCTGCCCCGCATTGAGGCAGCCTCCATGAGTGGGGCTGGGCGCCGCACCGTGCACCGGGAGACCGGCTCTGGGGGCTG
GCCCAACGGGCTCACCGTGGACTACCTGGAGAAGCGCATCCTTTGGATTGACGCCAGGTCAGATGCCATTTACTCAGCCCGTTACGACGG
CTCTGGCCACATGGAGGTGCTTCGGGGACACGAGTTCCTGTCGCACCCGTTTGCAGTGACGCTGTACGGGGGGGAGGTCTACTGGACTGA
CTGGCGAACAAACACACTGGCTAAGGCCAACAAGTGGACCGGCCACAATGTCACCGTGGTACAGAGGACCAACACCCAGCCCTTTGACCT
GCAGGTGTACCACCCCTCCCGCCAGCCCATGGCTCCCAATCCCTGTGAGGCCAATGGGGGCCAGGGCCCCTGCTCCCACCTGTGTCTCAT
CAACTACAACCGGACCGTGTCCTGCGCCTGCCCCCACCTCATGAAGCTCCACAAGGACAACACCACCTGCTATGAGTTTAAGAAGTTCCT
GCTGTACGCACGTCAGATGGAGATCCGAGGTGTGGACCTGGATGCTCCCTACTACAACTACATCATCTCCTTCACGGTGCCCGACATCGA
CAACGTCACAGTGCTAGACTACGATGCCCGCGAGCAGCGTGTGTACTGGTCTGACGTGCGGACACAGGCCATCAAGCGGGCCTTCATCAA
CGGCACAGGCGTGGAGACAGTCGTCTCTGCAGACTTGCCAAATGCCCACGGGCTGGCTGTGGACTGGGTCTCCCGAAACCTGTTCTGGAC
AAGCTATGACACCAATAAGAAGCAGATCAATGTGGCCCGGCTGGATGGCTCCTTCAAGAACGCAGTGGTGCAGGGCCTGGAGCAGCCCCA
TGGCCTTGTCGTCCACCCTCTGCGTGGGAAGCTCTACTGGACCGATGGTGACAACATCAGCATGGCCAACATGGATGGCAGCAATCGCAC
CCTGCTCTTCAGTGGCCAGAAGGGCCCCGTGGGCCTGGCTATTGACTTCCCTGAAAGCAAACTCTACTGGATCAGCTCCGGGAACCATAC
CATCAACCGCTGCAACCTGGATGGGAGTGGGCTGGAGGTCATCGATGCCATGCGGAGCCAGCTGGGCAAGGCCACCGCCCTGGCCATCAT
GGGGGACAAGCTGTGGTGGGCTGATCAGGTGTCGGAAAAGATGGGCACATGCAGCAAGGCTGACGGCTCGGGCTCCGTGGTCCTTCGGAA
CAGCACCACCCTGGTGATGCACATGAAGGTCTATGACGAGAGCATCCAGCTGGACCATAAGGGCACCAACCCCTGCAGTGTCAACAACGG
TGACTGCTCCCAGCTCTGCCTGCCCACGTCAGAGACGACCCGCTCCTGCATGTGCACAGCCGGCTATAGCCTCCGGAGTGGCCAGCAGGC
CTGCGAGGGCGTAGGTTCCTTTCTCCTGTACTCTGTGCATGAGGGAATCAGGGGAATTCCCCTGGATCCCAATGACAAGTCAGATGCCCT
GGTCCCAGTGTCCGGGACCTCGCTGGCTGTCGGCATCGACTTCCACGCTGAAAATGACACCATCTACTGGGTGGACATGGGCCTGAGCAC
GATCAGCCGGGCCAAGCGGGACCAGACGTGGCGTGAAGACGTGGTGACCAATGGCATTGGCCGTGTGGAGGGCATTGCAGTGGACTGGAT
CGCAGGCAACATCTACTGGACAGACCAGGGCTTTGATGTCATCGAGGTCGCCCGGCTCAATGGCTCCTTCCGCTACGTGGTGATCTCCCA
GGGTCTAGACAAGCCCCGGGCCATCACCGTCCACCCGGAGAAAGGGTACTTGTTCTGGACTGAGTGGGGTCAGTATCCGCGTATTGAGCG
GTCTCGGCTAGATGGCACGGAGCGTGTGGTGCTGGTCAACGTCAGCATCAGCTGGCCCAACGGCATCTCAGTGGACTACCAGGATGGGAA
GCTGTACTGGTGCGATGCACGGACAGACAAGATTGAACGGATCGACCTGGAGACAGGTGAGAACCGCGAGGTGGTTCTGTCCAGCAACAA
CATGGACATGTTTTCAGTGTCTGTGTTTGAGGATTTCATCTACTGGAGTGACAGGACTCATGCCAACGGCTCTATCAAGCGCGGGAGCAA
AGACAATGCCACAGACTCCGTGCCCCTGCGAACCGGCATCGGCGTCCAGCTTAAAGACATCAAAGTCTTCAACCGGGACCGGCAGAAAGG
CACCAACGTGTGCGCGGTGGCCAATGGCGGGTGCCAGCAGCTGTGCCTGTACCGGGGCCGTGGGCAGCGGGCCTGCGCCTGTGCCCACGG
GATGCTGGCTGAAGACGGAGCATCGTGCCGCGAGTATGCCGGCTACCTGCTCTACTCAGAGCGCACCATTCTCAAGAGTATCCACCTGTC
GGATGAGCGCAACCTCAATGCGCCCGTGCAGCCCTTCGAGGACCCTGAGCACATGAAGAACGTCATCGCCCTGGCCTTTGACTACCGGGC
AGGCACCTCTCCGGGCACCCCCAATCGCATCTTCTTCAGCGACATCCACTTTGGGAACATCCAACAGATCAACGACGATGGCTCCAGGAG
GATCACCATTGTGGAAAACGTGGGCTCCGTGGAAGGCCTGGCCTATCACCGTGGCTGGGACACTCTCTATTGGACAAGCTACACGACATC
CACCATCACGCGCCACACAGTGGACCAGACCCGCCCAGGGGCCTTCGAGCGTGAGACCGTCATCACTATGTCTGGAGATGACCACCCACG
GGCCTTCGTTTTGGACGAGTGCCAGAACCTCATGTTCTGGACCAACTGGAATGAGCAGCATCCCAGCATCATGCGGGCGGCGCTCTCGGG
AGCCAATGTCCTGACCCTTATCGAGAAGGACATCCGTACCCCCAATGGCCTGGCCATCGACCACCGTGCCGAGAAGCTCTACTTCTCTGA
CGCCACCCTGGACAAGATCGAGCGGTGCGAGTATGACGGCTCCCACCGCTATGTGATCCTAAAGTCAGAGCCTGTCCACCCCTTCGGGCT
GGCCGTGTATGGGGAGCACATTTTCTGGACTGACTGGGTGCGGCGGGCAGTGCAGCGGGCCAACAAGCACGTGGGCAGCAACATGAAGCT
GCTGCGCGTGGACATCCCCCAGCAGCCCATGGGCATCATCGCCGTGGCCAACGACACCAACAGCTGTGAACTCTCTCCATGCCGAATCAA
CAACGGTGGCTGCCAGGACCTGTGTCTGCTCACTCACCAGGGCCATGTCAACTGCTCATGCCGAGGGGGCCGAATCCTCCAGGATGACCT
CACCTGCCGAGCGGTGAATTCCTCTTGCCGAGCACAAGATGAGTTTGAGTGTGCCAATGGCGAGTGCATCAACTTCAGCCTGACCTGCGA
CGGCGTCCCCCACTGCAAGGACAAGTCCGATGAGAAGCCATCCTACTGCAACTCCCGCCGCTGCAAGAAGACTTTCCGGCAGTGCAGCAA
TGGGCGCTGTGTGTCCAACATGCTGTGGTGCAACGGGGCCGACGACTGTGGGGATGGCTCTGACGAGATCCCTTGCAACAAGACAGCCTG
TGGTGTGGGCGAGTTCCGCTGCCGGGACGGGACCTGCATCGGGAACTCCAGCCGCTGCAACCAGTTTGTGGATTGTGAGGACGCCTCAGA
TGAGATGAACTGCAGTGCCACCGACTGCAGCAGCTACTTCCGCCTGGGCGTGAAGGGCGTGCTCTTCCAGCCCTGCGAGCGGACCTCACT
CTGCTACGCACCCAGCTGGGTGTGTGATGGCGCCAATGACTGTGGGGACTACAGTGATGAGCGCGACTGCCCAGGTGTGAAACGCCCCAG
ATGCCCTCTGAATTACTTCGCCTGCCCTAGTGGGCGCTGCATCCCCATGAGCTGGACGTGTGACAAAGAGGATGACTGTGAACATGGCGA
GGACGAGACCCACTGCAACAAGTTCTGCTCAGAGGCCCAGTTTGAGTGCCAGAACCATCGCTGCATCTCCAAGCAGTGGCTGTGTGACGG
CAGCGATGACTGTGGGGATGGCTCAGACGAGGCTGCTCACTGTGAAGGCAAGACGTGCGGCCCCTCCTCCTTCTCCTGCCCTGGCACCCA
CGTGTGCGTCCCCGAGCGCTGGCTCTGTGACGGTGACAAAGACTGTGCTGATGGTGCAGACGAGAGCATCGCAGCTGGTTGCTTGTACAA
CAGCACTTGTGACGACCGTGAGTTCATGTGCCAGAACCGCCAGTGCATCCCCAAGCACTTCGTGTGTGACCACGACCGTGACTGTGCAGA
TGGCTCTGATGAGTCCCCCGAGTGTGAGTACCCGACCTGCGGCCCCAGTGAGTTCCGCTGTGCCAATGGGCGCTGTCTGAGCTCCCGCCA
GTGGGAGTGTGATGGCGAGAATGACTGCCACGACCAGAGTGACGAGGCTCCCAAGAACCCACACTGCACCAGCCAAGAGCACAAGTGCAA
TGCCTCGTCACAGTTCCTGTGCAGCAGTGGGCGCTGTGTGGCTGAGGCACTGCTCTGCAACGGCCAGGATGACTGTGGCGACAGCTCGGA
CGAGCGTGGCTGCCACATCAATGAGTGTCTCAGCCGCAAGCTCAGTGGCTGCAGCCAGGACTGTGAGGACCTCAAGATCGGCTTCAAGTG
CCGCTGTCGCCCTGGCTTCCGGCTGAAGGACGACGGCCGGACGTGTGCTGATGTGGACGAGTGCAGCACCACCTTCCCCTGCAGCCAGCG
CTGCATCAACACTCATGGCAGCTATAAGTGTCTGTGTGTGGAGGGCTATGCACCCCGCGGCGGCGACCCCCACAGCTGCAAGGCTGTGAC
TGACGAGGAACCGTTTCTGATCTTCGCCAACCGGTACTACCTGCGCAAGCTCAACCTGGACGGGTCCAACTACACGTTACTTAAGCAGGG
CCTGAACAACGCCGTTGCCTTGGATTTTGACTACCGAGAGCAGATGATCTACTGGACAGATGTGACCACCCAGGGCAGCATGATCCGAAG
GATGCACCTTAACGGGAGCAATGTGCAGGTCCTACACCGTACAGGCCTCAGCAACCCCGATGGGCTGGCTGTGGACTGGGTGGGTGGCAA
CCTGTACTGGTGCGACAAAGGCCGGGACACCATCGAGGTGTCCAAGCTCAATGGGGCCTATCGGACGGTGCTGGTCAGCTCTGGCCTCCG
TGAGCCCAGGGCTCTGGTGGTGGATGTGCAGAATGGGTACCTGTACTGGACAGACTGGGGTGACCATTCACTGATCGGCCGCATCGGCAT
GGATGGGTCCAGCCGCAGCGTCATCGTGGACACCAAGATCACATGGCCCAATGGCCTGACGCTGGACTATGTCACTGAGCGCATCTACTG
GGCCGACGCCCGCGAGGACTACATTGAATTTGCCAGCCTGGATGGCTCCAATCGCCACGTTGTGCTGAGCCAGGACATCCCGCACATCTT
TGCACTGACCCTGTTTGAGGACTACGTCTACTGGACCGACTGGGAAACAAAGTCCATTAACCGAGCCCACAAGACCACGGGCACCAACAA
AACGCTCCTCATCAGCACGCTGCACCGGCCCATGGACCTGCATGTCTTCCATGCCCTGCGCCAGCCAGACGTGCCCAATCACCCCTGCAA
GGTCAACAATGGTGGCTGCAGCAACCTGTGCCTGCTGTCCCCCGGGGGAGGGCACAAATGTGCCTGCCCCACCAACTTCTACCTGGGCAG
CGATGGGCGCACCTGTGTGTCCAACTGCACGGCTAGCCAGTTTGTATGCAAGAACGACAAGTGCATCCCCTTCTGGTGGAAGTGTGACAC
CGAGGACGACTGCGGGGACCACTCAGACGAGCCCCCGGACTGCCCTGAGTTCAAGTGCCGGCCCGGACAGTTCCAGTGCTCCACAGGTAT
CTGCACAAACCCTGCCTTCATCTGCGATGGCGACAATGACTGCCAGGACAACAGTGACGAGGCCAACTGTGACATCCACGTCTGCTTGCC
CAGTCAGTTCAAATGCACCAACACCAACCGCTGTATTCCCGGCATCTTCCGCTGCAATGGGCAGGACAACTGCGGAGATGGGGAGGATGA
GAGGGACTGCCCCGAGGTGACCTGCGCCCCCAACCAGTTCCAGTGCTCCATTACCAAACGGTGCATCCCCCGGGTCTGGGTCTGCGACCG
GGACAATGACTGTGTGGATGGCAGTGATGAGCCCGCCAACTGCACCCAGATGACCTGTGGTGTGGACGAGTTCCGCTGCAAGGATTCGGG
CCGCTGCATCCCAGCGCGTTGGAAGTGTGACGGAGAGGATGACTGTGGGGATGGCTCGGATGAGCCCAAGGAAGAGTGTGATGAACGCAC
CTGTGAGCCATACCAGTTCCGCTGCAAGAACAACCGCTGCGTGCCCGGCCGCTGGCAGTGCGACTACGACAACGATTGCGGTGACAACTC
CGATGAAGAGAGCTGCAGCTCTGCATTAGCTGCTAATGTATGTAAAAAGATTACTGGACGTCTTACAAGTGCAATAGCAAAACAGGAAGA
TGTCTCTGTTCAGCTAGAAGCCTTGGATATTATGGCTGATATGTTGAGCAGGCAAGGAGGACTTCTTGTTAATTTCCATCCTTCAATTCT
GACCTGTCTACTTCCCCAGTTGACCAGCCCTAGACTTGCAGTGAGGAAAAGAACCATTATCGCTCTTGGCCATCTGGTTATGAGCTGTGG
AAATATAGTTTTTGTAGATCTTATTGAACATCTGTTGTCAGAGTTGTCCAAAAATGATTCTATGTCAACAACAAGAACCTACATACAATG
TATTGCTGCTATTAGTAGGCAAGCTGGTCATAGAATAGGTGAATACCTTGAGAAGATAATTCCTTTGGTGGTAAAATTTTGCAATGTAGA
TGATGATGAATTAAGAGAGTACTGTATTCAAGCCTTTGAATCATTTGTAAGAAGATGTCCTAAGGAAGTATATCCTCATGTTTCTACCAT
TATAAATATTTGTCTTAAATATCTTACCTATGATCCAAATTATAATTACGATGATGAAGATGAAGATGAAAATGCAATGGATGCTGATGG
TGGTGATGATGATGATCAAGGGAGTGATGATGAATACAGTGATGATGATGACATGAGTTGGAAAGTGAGACGTGCAGCTGCGAAGTGCTT
GGATGCTGTAGTTAGCACAAGGCATGAAATGCTTCCAGAATTCTACAAGACCGTCTCTCCTGCACTAATATCCAGATTTAAAGAGCGTGA
AGAGAATGTAAAGGCAGATGTTTTTCACGCATACCTTTCTCTTTTGAAGCAAACTCGTCCTGTACAAAGTTGGCTATGTGACCCTGATGC
AATGGAGCAGGGAGAAACACCTTTAACAATGCTTCAGAGTCAGGTTCCCAACATTGTTAAAGCTCTTCACAAACAGATGAAAGAAAAAAG
TGTGAAGACCCGACAGTGTTGTTTTAACATGTTAACTGAGCTGGTAAATGTATTACCTGGGGCCCTAACTCAACACATTCCTGTACTTGT
ACCAGGAATCATTTTCTCACTGAATGATAAATCAAGCTCATCGAATTTGAAGATCGATGCTTTGTCATGTCTATACGTAATCCTCTGTAA
CCATTCTCCTCAAGTCTTCCATCCTCACGTTCAGGCTTTGGTTCCTCCAGTGGTGGCTTGTGTTGGAGACCCATTTTACAAAATTACATC
TGAAGCACTTCTTGTTACTCAACAGCTTGTCAAAGTAATTCGTCCTTTAGATCAGCCTTCCTCGTTTGATGCAACTCCTTATATCAAAGA
TCTATTTACCTGTACCATTAAGAGATTAAAAGCAGCTGACATTGATCAGGAAGTCAAGGAAAGGGCTATTTCCTGTATGGGACAAATTAT
TTGCAACCTTGGAGACAATTTGGGTTCTGACTTGCCTAATACACTTCAGATTTTCTTGGAGAGACTAAAGAATGAAATTACCAGGTTAAC
TACAGTAAAGGCATTGACACTGATTGCTGGGTCACCTTTGAAGATAGATTTGAGGCCTGTTCTGGGAGAAGGGGTTCCTATCCTTGCTTC
ATTTCTTAGAAAAAACCAGAGAGCTTTGAAACTGGGTACTCTTTCTGCCCTTGATATTCTAATAAAAAACTATAGTGACAGCTTGACAGC
TGCCATGATTGATGCAGTTCTAGATGAGCTCCCACCTCTTATCAGCGAAAGTGATATGCATGTTTCACAAATGGCCATCAGTTTTCTTAC
CACTTTGGCAAAAGTATATCCCTCCTCCCTTTCAAAGATAAGTGGATCCATTCTCAATGAACTTATTGGACTTGTGAGATCACCCTTATT
GCAGGGGGGAGCTCTTAGTGCCATGCTAGACTTTTTCCAAGCTCTGGTTGTCACTGGAACAAATAATTTAGGATACATGGATTTGTTGCG
CATGCTGACTGGTCCAGTTTACTCTCAGAGCACAGCTCTTACTCATAAGCAGTCTTATTATTCCATTGCCAAATGTGTAGCTGCCCTTAC
TCGAGCATGCCCTAAAGAGGGACCAGCTGTAGTAGGTCAGTTTATTCAAGATGTCAAGAACTCAAGGTCTACAGATTCCATTCGTCTCTT
AGCTCTACTTTCTCTTGGAGAAGTTGGGCATCATATTGACTTAAGTGGACAGTTGGAACTAAAATCTGTAATACTAGAAGCTTTCTCATC
TCCTAGTGAAGAAGTCAAATCAGCTGCATCCTATGCATTAGGCAGCATTAGTGTGGGCAACCTTCCTGAATATCTGCCGTTTGTCCTGCA
AGAAATAACTAGTCAACCCAAAAGGCAGTATCTTTTACTTCATTCCTTGAAGGAAATTATTAGCTCTGCATCAGTGGTGGGCCTTAAACC
ATATGTTGAAAACATCTGGGCCTTATTACTAAAGCACTGTGAGTGTGCAGAGGAAGGAACCAGAAATGTTGTTGCTGAATGTCTAGGAAA
ACTCACTCTAATTGATCCAGAAACTCTCCTTCCACGGCTTAAGGGGTACTTGATATCAGGCTCATCATATGCCCGAAGCTCAGTGGTTAC
GGCTGTGAAATTTACAATTTCTGACCATCCACAACCTATTGATCCACTGTTAAAGAACTGCATAGGTGATTTCCTAAAAACTTTGGAAGA
CCCAGATTTGAATGTGAGAAGAGTAGCCTTGGTCACATTTAATTCAGCAGCACATAACAAGCCATCATTAATAAGGGATCTATTGGATAC
TGTTCTTCCACATCTTTACAATGAAACAAAAGTTAGAAAGGAGCTTATAAGAGAGGTAGAAATGGGTCCATTTAAACATACGGTTGATGA
TGGTCTGGATATTAGAAAGGCAGCATTTGAGTGTATGTACACACTTCTAGACAGTTGTCTTGATAGACTTGATATCTTTGAATTTCTAAA
TCATGTTGAAGATGGTTTGAAGGACCATTATGATATTAAGATGCTGACATTTTTAATGTTGGTGAGACTGTCTACCCTTTGTCCAAGTGC
AGTACTGCAGAGGTTGGACCGACTTGTTGAGCCATTACGTGCAACATGTACAACTAAGGTAAAGGCAAACTCAGTAAAGCAGGAGTTTGA
AAAACAAGATGAATTAAAGCGATCTGCCATGAGAGCAGTAGCAGCACTGCTAACCATTCCAGAAGCAGAGAAGAGTCCACTGATGAGTGA
ATTCCAGTCACAGATCAGTTCTAACCCTGAGCTGGCGGCTATCTTTGAAAGTATCCAGAAAGATTCATCATCTACTAACTTGGAATCAAT
GGACACTAGTTAGATGTTTGTTCACCATGGGGACCATTACATATGACCATACAATGCACTGAATTGACAGGTTAATCATAAGACATGGAA
AGAGAAGTGTCTAAAAGCTTCAAAATGTTCCACTTTTTTTTCCTTCATGGAGACTGTTTGTTTGGCTTTCTTCCATTGTTGTTTTTGTAG
CATTTATTTCAGAAATGTGTATTTCCATAATCCAGAGGTTGTAAAACCACTAGTGTTTTAGTGGTTACAGCAACATTTGAAATGGAAACT
AAAAGTTAGGATTTTATGGAGTATGGAGATAGGGTCCAGTATCTATTTACCCTGTAATGTTTAGGATTAAAATGTTAAAATTTTGTGACC
ATGAATTTCTTTCTTTTATAAATTTTCTCATTTAAAAATCAAAAATCTTGCAAAACAAAAACCATGTTTCTTTTTCTTGTATAACTTTTT
GTTTTCAGCAACATAAATTGATTTTTAGCTGGCAGACAAGAATATCCATATAAGATTTGTTAACCATTTCAGAGAGTTTGGCAATTTTTA
AAAGATAATAAGGTATCATTTTTAAGTATGAAAATTAACAATATCCCTGTTGCGCACACTAATTTTGCATGAGTAAGTTTACAAATATGT
ATCGTCTGTAAAGCAGCATGTGCAGATTATTCATAATATAGAAGTTAAAATAAGTATTAGTGCAATTTTCAGATATTTATTTTTGCACAG
AAAACACATTATCTGGAGAGAAAGAAAGGAGAATTTTTGAGACTTGGGTTTTCTTAATGCCAGTGTGAATTTGCAGATGTTTTCAGAAAA
TCAAGTCACAGTAACAATTTGCCACTTTTTTCTATTATAAATCTTCTTACTTAAATTTTGAATATTTAGTTTTTCTCAGTTACCCATTTG
TGTGTGTGTGATTCCACTTAGAAATTCTTAAAACCAGATTTTTCTTTCATTCCGTTTGGATGTCTACATTCCTTATCAAAGGATATAAAT
ACTGTGTATGCTTTTGAATTTTATTTTTAGGAAAATTCTGAAGCCAGCTATCACAGGTTTGTTAGCTAATAATAGTATTTTCTTTTAGTT
GAGTTAGGTTTTTCCCCATCTCCTGTAGAGCGAATTTACATATTGTATTGGGTAAGTGTTCACTACTTTTCCTGATTAAGGGATCTGTGC
TGGGGAACAAAGCTTTTGCAGTACCTTATATTGTAGTTAAAATTTTATTTAACATATCCTTCAGTGAGCTCATTTCACACTGTAGCCTCT
TCCTTAAAATTTGTGGTGCTCCTGTAACAGTAAGAACTAATTCTGAAATAAAAGACATCTCCTAATGCTGTGCAAACATAGTTTACATGT
ATTGAAGGAGGCAGTTGTTAAATTGAGTGACCAATTTAAGCAATCAGATATTTGAAAACTGCACCCTTTAGTTTTGAAACTGTGAATTAG
AAACACTTTTCCTGCTGTATTACTACCTGCTTTAACATCCAAATATACAGTGATTTTAAATGATAACATACTGTGGTTATTAGATTAACA
GCTTGATTTTGAATGTTCAGATGATAATGCAGAAGACATCACTTCTAGTAAGGATTTTGACTAGTGCATTGATGTTGAAGTTGGTGCCAT
TTCAAAATGTGGCAGGTGATAATCTTTTACCATAATTTGCATAAAACTGTAATAGAAGTTTATTTTGAGATGTTAGTATATTATGTACTA
TGCATTTCTGTGGTATAGATGTTGTGGATATATTTAAGTATTTGGTTACATGGTTTTACAATAAATTACAATACTGCAGGCTCTAGGACT
GAACAGGAGACTGACATGCATATGTTGTGTGAATGTCTTAGTTGGGTAAAGTTAAATCCAAATACTTCAACTGGCTTTTTCTTCAGTTTG
TTTGTTTTTAACTTTCAAGATGCATGTTTTGTTTTGTTTTGCTTTGTTTTTGTCTCTTAAGCCAATTCATTTTTCTAACAGTTGAAATTC
TTTTAGTACTAAAGAAATAGATACTGCTCTTTTATGGCTTTAGTGTTTATATACCTGTTTATATGCATACATTAACAAAATTAGTAACAG
CAGTGCTTAGAATTTCAATGCTGTGTCATACTGATGATTAACTCCATACTCCTAGTGGTGATGTGGTCCAGATACTGGAATGGAAGTGGC
AGGATGTGGAGTCCAGACATAGTCTACCACTCATGCTACTTACTAGTAATATTAAGGTGTTAAACTTAGGAATTTGTCACATGTAGGTTC
CTGAGGAGATCTAAAAGTTAATACAAAACCAAGCTGTTTACTGATTTTCATGAGAACATTTAAGTTAGTTTAGGTCTACCTGATTTATTT
TAAAAGAAGGCAGAGGGCTGGACGCAGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAG
ATCGAGACTATCCTGGCTAACACTGTGAAAACCCATCTCTACTGAAAATACAAAAAATTAGCTGGGCGTGGTGGCAGACGCCTGTAGTCC
TAGCTGCTACAGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTGGCAGTGAGCCGAGATCACGCCACTGCACTCTGGCCTGG
GCAACAGAGCGAGAGTCTGTCTCAAAAAAAAAAAAAAAAAAAAGGCAGGAAGGAAATTTGGTATGGCAGGGCCTAACCTAAAAGGTTATT
TATAAAATCAATAGCACTGAATGATAATTTTTTTAATGACAGTCATGTATTTTATTAATGATATCTGAAAGCTGCTTAACCATTAGGAAT
TACAATTCTTTATGGTTGGAGTATGATGATTTCATCAAATGTTTGAATATTTACATAATTTTTATGTAACCATAATTAAACCAAATTAGT
CTTTTTTTCTTCATACTTTTCTTCGGTAAATAGTGAAGAAATAATGGGCATATCTAATTAACCAGTTCTAGTGGGTGTTGTGATATCTTT
ATATCTAGTTCAGTCTCAGATGTATGAATATGATTATATAGTCATGATTGAAGTTCAAAATGAGGAAGTATACAAAATCCTCAGCCACTG
AAAAATTCAGTTAACTTGTTTATACTCCTGTAAGCTCTAGTTAGTCACAAGACAAAGTATATAGTAACACTTTGTAATGAAGTAACATTT
TCTGCCCACATTAATTTTACTAAAGACCTAAATTGTTAAAATTAATTGCCAATCTCTGGATATATTATGCTTAGTAAGTGTTTTGAAATT
AAAGACCTTAAACATTTCAGCAAGTAAATTTTGGATTCTAGCTCTGTTTTAAATTGAATCCTAATTTTCAAACCACTGCTACCCCAGATT
CATACCTGTTTTTGAAATCTTGTTTATGGAATGGAAAATTGACAGTATGGTAATAGTTTATTGACTGATTGGACAAAGGATATTCTGGTT
TTAACTGACTTTTCCATTTAAATAAAATTCATTTGATAATTTTGGTTGCAAAAGTGGAACACAGTGGAAGTATTTGGCTACAGGCTACCC
AAATCTCATCAGATAAGGCTGTTTTCTTAAAGGAAATGCAAAATGAAATCATATGTTTTCCTTTTCCAATACAGTAAATTGCTTGTTTTC
CTATGAATATCAGAAAAGATTTTGTAAACACCTTTGCTGTAGTTTCAGGCAAGATCTTTCAGCAACATGTTTTTGCTCTTTGTAACTTAG
AAAGTTAGCTCTGAATCCAAAAACTACTGAAGTGAGTAATGCATATAATTTTACTTTTTTGGACCCTATAATGCCAGTGTGTCAGGTTTC
AGAATGATATTTAGTAGACAGAAATACCTAATTTTGTTTTGGAATCTTAATACCCTGTCCTCTTCATAACTTTCTAGTGGTGATTTTAGC
AAGTTTAATTATTTTGCTGAGGTCTTAGAAGACAGAAAGCTTATGCTATGTAAAGTGACATTGTTTCCAGATTAGGAAGTATTGGAATTA
ATTTGCTATTGCCAGTAAGTAATGGTTGATGGATATTAAGTGATTTTAGTCTAGAATGCTCTCAAAAAAATAGTAAAGAATTGTACTTCA
GGGCCAGATGGCAGCTCACGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGGGGATCACTTGAAGACAGGAGTTGGAGACCAGCTCT
AGGCAACATAGTGAGACCCTGTCTCTACCAAAAAGAAGAAAAAAGAAATCAACAACATGCAACCATAAGAATGGATGAGATGGCCCTAAA
AGAATAAGGATTACATATAATGAGAAGACGTGTGGGCTGAAATACCTAGTGAACAATATTTAAGGGAAACTGAAGTGCAAATGGCCTCAC
AGGTTTGTTTTTGTGTTTAAGACAAGGTCTCACTCTGTTGCCTGGACTGGAGTACATAGCACGAACATGGTTTACTGCACCTCAGCTTCC
TGGGCACAAGTGATTCTCCCACCTCAGCCTCCCGAGTAGCTGGGAGTATAGGTGTGTGCCACCACGTCCAGCTAATTTTTTTATTTCCTT
GTGGAGATGGGGTCTCATGACCTTGTCCAGGATGATCTCAAACTCCTGGGCTCAAGCAATCCTGTGTTGGCCTCCTAAACTGCTGAGATT
ATTGCAAGTGCCTCCTTGCCCAGCCACATGTTGTTGATTTCTTTTTTCTTTTTTTTTCTTTCTTAATTTTTTTTTTTTTTTTTTTTTTTG
AGATTGATGGAGTCTTGCTTTGTCTCCCAGGCTGGAGTGCAGTGGCGCAATATCGGCTCACTGCAACCTCTGCCTCCCGGGTTCTAGCTA
TTCTCCTGCCTCAGCCTCCCAAGTAGCTGTGATTACAGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGAGTT
TTGCCATGTTGGCCAGGCTGGTTTCAAACTCCTGATCTTAGGTGATACACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAG
CCACGTCCCCCAGCCAGTTTCTTAATCTATACATCTAGCCCAGTCCATGCCCCTGTTTCAGACTATTATATCCAACCACCTGCTATACAT
CTCATAAAGGTATCTCAAACACAGCATATCTAAAGCTGAAGTCATCATCTTGCCCTGGTTTTTCCTGTCTCTTTGCTGATGGCATCCCAT
TTACCCAGTCATTCAAACTGGAAATCTAAAAGCCTCACTTAGCAAGAGTTTGGAGGCAGAATATGATAAAGAACAAGGACTCTGGGAGGC
CAAGGCAGGTGGATTGCTTGAGGTCAAGAGTTCGAGACCAGTCTGGCCAACATGGCGAAACCCCGTCTTTGCTAAAAAAACACAAAGAAA
TTAGCTAGACGTGGTGGCACATGCCTGTAGTCCCAGCTGTGTGGGAGGCTGAGGCAGGGGAATTGCTTGAACCTGGGAGGTGGAGGTTGC
AGTGACCCAAGATTGCATGCACCACTGCACTCCAGCCTGGGTGACAAAGCGAGACCCTGTCTCAAAAAAAACAAGGACTCTACAGATAGA
TAGACATCATATATCATATTAGTTTGAATCCTGGCTGTTAGCTGTTAGACTTGGGCAAATAATTTAACCTCAACTTTCCCTATCTATAAA
ATGGGAATTAAAATATTTGCACCTTATAGGGTTATTGTGAGGATTAAATAGGAACATTGTATAAAGCACTTAAAACAGTACCTGGGACAT
ACTAAGTAATATAATTGTTAACTCTTACTAGCATTCTGTCCCTTTTATTTCCTAAATATCTCTCATGCCCATCTCCTAAATATCTCTTTC
CTAAATATCTCTCATGCTTTTGGCTTAAGACCTCTTTTCCTCCTTATCTATTGACTGGACTGCGGCAAATGCCTGCTAATCGTTATTTTT
GTGTTCATTCATTTAGCAAGCCAATTTATTACGCGCTTAGGGTGCTGCCAGGGCTACAAAAGCTGTTGAGACTGTACTTGATATGAAGAA
GCTTGCTGATTATCATGGGAAGACTGACATAAGGAAGCACCATAAAATTCTGCTGTATGAGAGGTATACACGGGATACTGGGGGTTAATA
ATTGAGGGTATGGTCCATTCAACATGAGTGAGACAGAAACAATTCATAAAGGAGATGAAATGTCTTGAGGAATGAGCTCTTAGAAGAATA
GTTTTCAAATGAGTGTGCATCACAGTCACCTGTAAGACTTATTAAAACAGATCGCTGGGCCCTACACCCAGAGGCTGTGGTTCAGTAGGC
TGTAGTAAACCAGTAATTTGTATTTCTATGACGTTCCCAGGTTCTAATGCTGTTCCCCAAGGCCACACCTTGGAAACCACCACATTAAAA
TACCCAGAAGGCATTAATTCCCAGTCCTTCCTCTACACAGCTGCAAAACAATGGTCCTGACCATTTCATCTTTGCACTACATCCTTCACT
GTCTCTCTTTTGCCCATAGGATAAGTACAAACTAGATCTGGTTACTGCCTGCCCCACCAGCCTCAGCATCTCTCACAACTAGGACTAACT
TTTTCTTCTGACAACTATAAAATATTTCCCTTGCCTTCTCAAGTTTGCTCAAGGTCAAGTTATGCCTTTTGCCTGGAATGACTTGACTTC
TCTTTTGTTTTACTTAGCTGGCTGCTTTTCATCTTGTAGGTTAGGTCAAGGACTCCAGGAAGTCTTCCCTGGACAAGTAATGAAGAGGGC
ATAATCCAAGGGCCAACTCCCATGTTTGGAACCTGACTCCATTTTCAGGCACGTAATATTGTCAAATTCCTTTTAAAAGCACCTGTCTGT
CTGTTAACGTTGGTGCAGATACTGCTATTCCCCTCCTCCATACCATTGCTGATGGTTACTGAGGGTATGGGAAGGGCCGACTAGTCCAGC
TGTTCACAAACAGCCCTTAATGTCAAACTGAATACTGCCAACGTAGTTCCAGTTTCTGTATCTAAAGACTCAGCTTGGAGTCACTTGTCT
GGACTAAAAGTAACCCCTCCTTGTCTGGTTTGTGACTTTCTGTACTCTGATGCCCCCAGCTTTCTGCCTTCTAGAAATTTGTCAGAATTT
CCAAAATTCTTGGGCCTTCCTTCTTGCTCTATATATGGTTTTGGATTCATTCCTTTTAAAAAATATTTACTGTCATTTCAGTAGAATTTT

>49739_49739_1_LRP1-CAND1_LRP1_chr12_57596320_ENST00000243077_CAND1_chr12_67688813_ENST00000545606_length(amino acids)=4686AA_BP=3579
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDG
PKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGR
LYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQV
GTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ
HTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQF
TCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLD
GLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPP
DKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGW
VLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYG
LATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGS
GGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQP
FDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVP
DIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLE
QPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATAL
AIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSG
QQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAV
DWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQ
DGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDR
QKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFD
YRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDD
HPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHP
FGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQ
DDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNK
TACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVK
RPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCP
GTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLS
SRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIG
FKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLL
KQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSS
GLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIP
HIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFY
LGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHV
CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCK
DSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCSSALAANVCKKITGRLTSAIAK
QEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTY
IQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMD
ADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCD
PDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVI
LCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMG
QIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDS
LTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMD
LLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEA
FSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAEC
LGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDL
LDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLC
PSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNL

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Fusion Gene PPI Analysis for LRP1-CAND1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	LRP1	chr12:57596320	chr12:67688813	ENST00000243077	+	68	89	4445_4544	3570.3333333333335	4545.0	MAFB

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LRP1-CAND1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LRP1-CAND1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source