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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRP1-FAM19A2 (FusionGDB2 ID:49743)

Fusion Gene Summary for LRP1-FAM19A2

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP1-FAM19A2
Fusion gene ID: 49743
HgeneTgene
Gene symbol

LRP1

FAM19A2

Gene ID

10438

338811

Gene nameC1D nuclear receptor corepressorTAFA chemokine like family member 2
SynonymsLRP1|Rrp47|SUN-CoR|SUNCOR|hC1DFAM19A2|TAFA-2
Cytomap

2p14

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressorchemokine-like protein TAFA-2family with sequence similarity 19 (chemokine (C-C motif)-like), member A2family with sequence similarity 19 member A2, C-C motif chemokine likeprotein FAM19A2
Modification date2020031320200313
UniProtAcc

Q07954

.
Ensembl transtripts involved in fusion geneENST00000243077, ENST00000338962, 
ENST00000553277, ENST00000553446, 
ENST00000554174, 		ENST00000549456, 
ENST00000416284, ENST00000551449, 
ENST00000551619, ENST00000550003, 
Fusion gene scores* DoF score23 X 27 X 12=745214 X 10 X 6=840
# samples 2614
** MAII scorelog2(26/7452*10)=-4.84104414591318
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/840*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP1 [Title/Abstract] AND FAM19A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRP1(57569488)-FAM19A2(62104198), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM19A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HS-01ALRP1chr12

57569488

-FAM19A2chr12

62104198

-
ChimerDB4SARCTCGA-3B-A9HS-01ALRP1chr12

57569488

+FAM19A2chr12

62104198

-


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Fusion Gene ORF analysis for LRP1-FAM19A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000243077ENST00000549456LRP1chr12

57569488

+FAM19A2chr12

62104198

-
Frame-shiftENST00000243077ENST00000416284LRP1chr12

57569488

+FAM19A2chr12

62104198

-
Frame-shiftENST00000243077ENST00000551449LRP1chr12

57569488

+FAM19A2chr12

62104198

-
Frame-shiftENST00000243077ENST00000551619LRP1chr12

57569488

+FAM19A2chr12

62104198

-
In-frameENST00000243077ENST00000550003LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000338962ENST00000416284LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000338962ENST00000550003LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000338962ENST00000551449LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000338962ENST00000551619LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553277ENST00000416284LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553277ENST00000550003LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553277ENST00000551449LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553277ENST00000551619LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553446ENST00000416284LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553446ENST00000550003LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553446ENST00000551449LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000553446ENST00000551619LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000554174ENST00000416284LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000554174ENST00000550003LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000554174ENST00000551449LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-3CDSENST00000554174ENST00000551619LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-intronENST00000338962ENST00000549456LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-intronENST00000553277ENST00000549456LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-intronENST00000553446ENST00000549456LRP1chr12

57569488

+FAM19A2chr12

62104198

-
intron-intronENST00000554174ENST00000549456LRP1chr12

57569488

+FAM19A2chr12

62104198

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000243077LRP1chr1257569488+ENST00000550003FAM19A2chr1262104198-6400425944243021286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000243077ENST00000550003LRP1chr1257569488+FAM19A2chr1262104198-0.0014927630.9985072

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Fusion Genomic Features for LRP1-FAM19A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRP1-FAM19A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57569488/chr12:62104198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP1

Q07954

.
FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). {ECO:0000250|UniProtKB:Q91ZX7, ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:1702392, ECO:0000269|PubMed:26142438, ECO:0000269|PubMed:32296178}.; FUNCTION: (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891013_105312644545.0DomainLDL-receptor class A 7
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891060_109912644545.0DomainLDL-receptor class A 8
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891102_114212644545.0DomainLDL-receptor class A 9
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389111_14912644545.0DomainEGF-like 1
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891143_118212644545.0DomainLDL-receptor class A 10
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891183_122212644545.0DomainEGF-like 5
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891223_126212644545.0DomainEGF-like 6
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389150_18912644545.0DomainEGF-like 2%3B calcium-binding
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+238925_6612644545.0DomainLDL-receptor class A 1
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389474_52012644545.0DomainEGF-like 3
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+238970_11012644545.0DomainLDL-receptor class A 2
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389803_84312644545.0DomainEGF-like 4
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389852_89212644545.0DomainLDL-receptor class A 3
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389893_93312644545.0DomainLDL-receptor class A 4
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389934_97312644545.0DomainLDL-receptor class A 5
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389974_101312644545.0DomainLDL-receptor class A 6
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389292_33412644545.0RepeatNote=LDL-receptor class B 1
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389335_37812644545.0RepeatNote=LDL-receptor class B 2
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389379_42212644545.0RepeatNote=LDL-receptor class B 3
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389571_61312644545.0RepeatNote=LDL-receptor class B 4
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389614_65912644545.0RepeatNote=LDL-receptor class B 5
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389660_71012644545.0RepeatNote=LDL-receptor class B 6
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+2389711_75412644545.0RepeatNote=LDL-receptor class B 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891536_157912644545.0DomainEGF-like 7
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891846_188712644545.0DomainEGF-like 8
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892155_219512644545.0DomainEGF-like 9
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892478_251812644545.0DomainEGF-like 10
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892522_256312644545.0DomainLDL-receptor class A 11
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892564_260212644545.0DomainLDL-receptor class A 12
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892603_264112644545.0DomainLDL-receptor class A 13
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892642_269012644545.0DomainLDL-receptor class A 14
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892694_273212644545.0DomainLDL-receptor class A 15
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892732_277112644545.0DomainLDL-receptor class A 16
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892772_281412644545.0DomainLDL-receptor class A 17
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892816_285512644545.0DomainLDL-receptor class A 18
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892856_289912644545.0DomainLDL-receptor class A 19
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892902_294012644545.0DomainLDL-receptor class A 20
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892941_298112644545.0DomainEGF-like 11
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892982_302212644545.0DomainEGF-like 12%3B calcium-binding
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893290_333112644545.0DomainEGF-like 13
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893332_337112644545.0DomainLDL-receptor class A 21
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893372_341012644545.0DomainLDL-receptor class A 22
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893411_345012644545.0DomainLDL-receptor class A 23
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893451_349112644545.0DomainLDL-receptor class A 24
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893492_353312644545.0DomainLDL-receptor class A 25
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893534_357212644545.0DomainLDL-receptor class A 26
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893573_361112644545.0DomainLDL-receptor class A 27
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893611_364912644545.0DomainLDL-receptor class A 28
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893652_369212644545.0DomainLDL-receptor class A 29
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893693_373312644545.0DomainLDL-receptor class A 30
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893739_377812644545.0DomainLDL-receptor class A 31
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893781_382312644545.0DomainEGF-like 14
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893824_386112644545.0DomainEGF-like 15
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894147_418312644545.0DomainEGF-like 16
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894196_423212644545.0DomainEGF-like 17
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894232_426812644545.0DomainEGF-like 18
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894268_430412644545.0DomainEGF-like 19
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894304_434012644545.0DomainEGF-like 20
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894340_437512644545.0DomainEGF-like 21
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894373_440912644545.0DomainEGF-like 22
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893940_394312644545.0MotifRecognition site for proteolytical processing
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894502_450712644545.0MotifNote=NPXY motif
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891309_135512644545.0RepeatNote=LDL-receptor class B 8
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891356_139812644545.0RepeatNote=LDL-receptor class B 9
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891399_144512644545.0RepeatNote=LDL-receptor class B 10
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891446_149012644545.0RepeatNote=LDL-receptor class B 11
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891491_153112644545.0RepeatNote=LDL-receptor class B 12
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891627_166912644545.0RepeatNote=LDL-receptor class B 13
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891670_171312644545.0RepeatNote=LDL-receptor class B 14
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891714_175312644545.0RepeatNote=LDL-receptor class B 15
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891754_179812644545.0RepeatNote=LDL-receptor class B 16
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891934_197612644545.0RepeatNote=LDL-receptor class B 17
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23891977_201912644545.0RepeatNote=LDL-receptor class B 18
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892020_206312644545.0RepeatNote=LDL-receptor class B 19
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892064_210712644545.0RepeatNote=LDL-receptor class B 20
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892253_229412644545.0RepeatNote=LDL-receptor class B 21
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892295_234312644545.0RepeatNote=LDL-receptor class B 22
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892344_238812644545.0RepeatNote=LDL-receptor class B 23
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892389_243112644545.0RepeatNote=LDL-receptor class B 24
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23892432_247312644545.0RepeatNote=LDL-receptor class B 25
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893069_311312644545.0RepeatNote=LDL-receptor class B 26
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893114_315612644545.0RepeatNote=LDL-receptor class B 27
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893157_320012644545.0RepeatNote=LDL-receptor class B 28
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893201_324312644545.0RepeatNote=LDL-receptor class B 29
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893244_328412644545.0RepeatNote=LDL-receptor class B 30
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893912_395412644545.0RepeatNote=LDL-receptor class B 31
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23893970_401212644545.0RepeatNote=LDL-receptor class B 32
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894013_405612644545.0RepeatNote=LDL-receptor class B 33
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894057_410112644545.0RepeatNote=LDL-receptor class B 34
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+238920_441912644545.0Topological domainExtracellular
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894420_444412644545.0TransmembraneHelical


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Fusion Gene Sequence for LRP1-FAM19A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49743_49743_1_LRP1-FAM19A2_LRP1_chr12_57569488_ENST00000243077_FAM19A2_chr12_62104198_ENST00000550003_length(transcript)=6400nt_BP=4259nt
CAGCGGTGCGAGCTCCAGGCCCATGCACTGAGGAGGCGGAAACAAGGGGAGCCCCCAGAGCTCCATCAAGCCCCCTCCAAAGGCTCCCCT
ACCCGGTCCACGCCCCCCACCCCCCCTCCCCGCCTCCTCCCAATTGTGCATTTTTGCAGCCGGAGGCGGCTCCGAGATGGGGCTGTGAGC
TTCGCCCGGGGAGGGGGAAAGAGCAGCGAGGAGTGAAGCGGGGGGGTGGGGTGAAGGGTTTGGATTTCGGGGCAGGGGGCGCACCCCCGT
CAGCAGGCCCTCCCCAAGGGGCTCGGAACTCTACCTCTTCACCCACGCCCCTGGTGCGCTTTGCCGAAGGAAAGAATAAGAACAGAGAAG
GAGGAGGGGGAAAGGAGGAAAAGGGGGACCCCCCAACTGGGGGGGGTGAAGGAGAGAAGTAGCAGGACCAGAGGGGAAGGGGCTGCTGCT
TGCATCAGCCCACACCATGCTGACCCCGCCGTTGCTCCTGCTGCTGCCCCTGCTCTCAGCTCTGGTCGCGGCGGCTATCGACGCCCCTAA
GACTTGCAGCCCCAAGCAGTTTGCCTGCAGAGATCAAATAACCTGTATCTCAAAGGGCTGGCGGTGCGACGGTGAGAGGGACTGCCCAGA
CGGATCTGACGAGGCCCCTGAGATTTGTCCACAGAGTAAGGCCCAGCGATGCCAGCCAAACGAGCATAACTGCCTGGGTACTGAGCTGTG
TGTTCCCATGTCCCGCCTCTGCAATGGGGTCCAGGACTGCATGGACGGCTCAGATGAGGGGCCCCACTGCCGAGAGCTCCAAGGCAACTG
CTCTCGCCTGGGCTGCCAGCACCATTGTGTCCCCACACTCGATGGGCCCACCTGCTACTGCAACAGCAGCTTTCAGCTTCAGGCAGATGG
CAAGACCTGCAAAGATTTTGATGAGTGCTCAGTGTACGGCACCTGCAGCCAGCTATGCACCAACACAGACGGCTCCTTCATATGTGGCTG
TGTTGAAGGATACCTCCTGCAGCCGGATAACCGCTCCTGCAAGGCCAAGAACGAGCCAGTAGACCGGCCCCCTGTGCTGTTGATAGCCAA
CTCCCAGAACATCTTGGCCACGTACCTGAGTGGGGCCCAGGTGTCTACCATCACACCTACGAGCACGCGGCAGACCACAGCCATGGACTT
CAGCTATGCCAACGAGACCGTATGCTGGGTGCATGTTGGGGACAGTGCTGCTCAGACGCAGCTCAAGTGTGCCCGCATGCCTGGCCTAAA
GGGCTTCGTGGATGAGCACACCATCAACATCTCCCTCAGTCTGCACCACGTGGAACAGATGGCCATCGACTGGCTGACAGGCAACTTCTA
CTTTGTGGATGACATCGATGATAGGATCTTTGTCTGCAACAGAAATGGGGACACATGTGTCACATTGCTAGACCTGGAACTCTACAACCC
CAAGGGCATTGCCCTGGACCCTGCCATGGGGAAGGTGTTTTTCACTGACTATGGGCAGATCCCAAAGGTGGAACGCTGTGACATGGATGG
GCAGAACCGCACCAAGCTCGTCGACAGCAAGATTGTGTTTCCTCATGGCATCACGCTGGACCTGGTCAGCCGCCTTGTCTACTGGGCAGA
TGCCTATCTGGACTATATTGAAGTGGTGGACTATGAGGGCAAGGGCCGCCAGACCATCATCCAGGGCATCCTGATTGAGCACCTGTACGG
CCTGACTGTGTTTGAGAATTATCTCTATGCCACCAACTCGGACAATGCCAATGCCCAGCAGAAGACGAGTGTGATCCGTGTGAACCGCTT
TAACAGCACCGAGTACCAGGTTGTCACCCGGGTGGACAAGGGTGGTGCCCTCCACATCTACCACCAGAGGCGTCAGCCCCGAGTGAGGAG
CCATGCCTGTGAAAACGACCAGTATGGGAAGCCGGGTGGCTGCTCTGACATCTGCCTGCTGGCCAACAGCCACAAGGCGCGGACCTGCCG
CTGCCGTTCCGGCTTCAGCCTGGGCAGTGACGGGAAGTCATGCAAGAAGCCGGAGCATGAGCTGTTCCTCGTGTATGGCAAGGGCCGGCC
AGGCATCATCCGGGGCATGGATATGGGGGCCAAGGTCCCGGATGAGCACATGATCCCCATTGAAAACCTCATGAACCCCCGAGCCCTGGA
CTTCCACGCTGAGACCGGCTTCATCTACTTTGCCGACACCACCAGCTACCTCATTGGCCGCCAGAAGATTGATGGCACTGAGCGGGAGAC
CATCCTGAAGGACGGCATCCACAATGTGGAGGGTGTGGCCGTGGACTGGATGGGAGACAATCTGTACTGGACGGACGATGGGCCCAAAAA
GACAATCAGCGTGGCCAGGCTGGAGAAAGCTGCTCAGACCCGCAAGACTTTAATCGAGGGCAAAATGACACACCCCAGGGCTATTGTGGT
GGATCCACTCAATGGGTGGATGTACTGGACAGACTGGGAGGAGGACCCCAAGGACAGTCGGCGTGGGCGGCTGGAGAGGGCGTGGATGGA
TGGCTCACACCGAGACATCTTTGTCACCTCCAAGACAGTGCTTTGGCCCAATGGGCTAAGCCTGGACATCCCGGCTGGGCGCCTCTACTG
GGTGGATGCCTTCTACGACCGCATCGAGACGATACTGCTCAATGGCACAGACCGGAAGATTGTGTATGAAGGTCCTGAGCTGAACCACGC
CTTTGGCCTGTGTCACCATGGCAACTACCTCTTCTGGACTGAGTATCGGAGTGGCAGTGTCTACCGCTTGGAACGGGGTGTAGGAGGCGC
ACCCCCCACTGTGACCCTTCTGCGCAGTGAGCGGCCCCCCATCTTTGAGATCCGAATGTATGATGCCCAGCAGCAGCAAGTTGGCACCAA
CAAATGCCGGGTGAACAATGGCGGCTGCAGCAGCCTGTGCTTGGCCACCCCTGGGAGCCGCCAGTGCGCCTGTGCTGAGGACCAGGTGTT
GGACGCAGACGGCGTCACTTGCTTGGCGAACCCATCCTACGTGCCTCCACCCCAGTGCCAGCCAGGCGAGTTTGCCTGTGCCAACAGCCG
CTGCATCCAGGAGCGCTGGAAGTGTGACGGAGACAACGATTGCCTGGACAACAGTGATGAGGCCCCAGCCCTCTGCCATCAGCACACCTG
CCCCTCGGACCGATTCAAGTGCGAGAACAACCGGTGCATCCCCAACCGCTGGCTCTGCGACGGGGACAATGACTGTGGGAACAGTGAAGA
TGAGTCCAATGCCACTTGTTCAGCCCGCACCTGCCCCCCCAACCAGTTCTCCTGTGCCAGTGGCCGCTGCATCCCCATCTCCTGGACGTG
TGATCTGGATGACGACTGTGGGGACCGCTCTGATGAGTCTGCTTCGTGTGCCTATCCCACCTGCTTCCCCCTGACTCAGTTTACCTGCAA
CAATGGCAGATGTATCAACATCAACTGGAGATGCGACAATGACAATGACTGTGGGGACAACAGTGACGAAGCCGGCTGCAGCCACTCCTG
TTCTAGCACCCAGTTCAAGTGCAACAGCGGGCGTTGCATCCCCGAGCACTGGACCTGCGATGGGGACAATGACTGCGGAGACTACAGTGA
TGAGACACACGCCAACTGCACCAACCAGGCCACGAGGCCCCCTGGTGGCTGCCACACTGATGAGTTCCAGTGCCGGCTGGATGGACTATG
CATCCCCCTGCGGTGGCGCTGCGATGGGGACACTGACTGCATGGACTCCAGCGATGAGAAGAGCTGTGAGGGAGTGACCCACGTCTGCGA
TCCCAGTGTCAAGTTTGGCTGCAAGGACTCAGCTCGGTGCATCAGCAAAGCGTGGGTGTGTGATGGCGACAATGACTGTGAGGATAACTC
GGACGAGGAGAACTGCGAGTCCCTGGCCTGCAGGCCACCCTCGCACCCTTGTGCCAACAACACCTCAGTCTGCCTGCCCCCTGACAAGCT
GTGTGATGGCAACGACGACTGTGGCGACGGCTCAGATGAGGGCGAGCTCTGCGACCAGTGCTCTCTGAATAACGGTGGCTGCAGCCACAA
CTGCTCAGTGGCACCTGGCGAAGGCATTGTGTGTTCCTGCCCTCTGGGCATGGAGCTGGGGCCCGACAACCACACCTGCCAGATCCAGAG
CTACTGTGCCAAGCATCTCAAATGCAGCCAAAAGTGCGACCAGAACAAGTTCAGCGTGAAGTGCTCCTGCTACGAGGGCTGGGTCCTGGA
ACCTGACGGCGAGAGCTGCCGCAGCCTGGGTAACCCATTAACCCAGGAGAAATCAAGTGATCCTCAAGGCTGATGACATTGAACATGCGC
ATAGAAACTTAACTCAACTCCTGAGGTGATCTTGAAGATTTTTATACCACTTGAAAGAGGCGCTCAATAGTCTATTTCCAAGGGATTTCA
TGGCCTCTTCTTGAAATCAAGACTTTTTAAAAGTCAGACATGAACTTGCATGTCATGAAGATTTCAGCAGATTTGAACTGTGTTCAACTT
GTAAATTGTTAAAAGAATTTGAAGTCACTGTCTGAGGAGCTGGTGAAGAGTTGTTTTTTTCAGGGTGATGTTAGAGACAGTCACCTTTTG
AGTTATTGGCTCCAGATGTGACTACTTTTCTTGTTTCTGCAAGCTGTATCCCAAGTGCACTGTCCTTCTGTCCTGGATGTGTTCCTGGGT
CCTATGTTCATTTGCTAGTGGGACTACACATGGCTTTAATGACATTTCCTTTGAGAACTTTTCCTCTGGCATGGTGTAGACTGAGACAAT
TTTATTTATATCCTAATCTTGGAGCTCAGAAAGCCTACATGTTTTAACATCTTAAAGTTGCTTTTGTTAAAGGAATGGAAATATATATCC
ATTGGTAATAATGTTGGCAAGTAATAGTTATCTGAATAAATCAATCATATAAGAATGTATAGACAAGCTGACATATTTCCCTAAGGCTAA
CAACACCCTGCTGAAGCTCTTTGTCAAATAGGTAGTAGTTAGAACTGGATTGCCATTTTCATTATATAATACTTTGTACCTCTAGAGCAC
TCTCCCTTTCTGTTTTTTTTTAAGTGAGCTTTTCTTTAATTTTTTATGTTTACTTATTCCCTTCACAGAAATCAGCAGTGAGCAGTCAAG
TTAATGGGTAGCCTTCAGTTTCAAAAAAATTGACAGGGATGCATGTGAGTTTCTGATTTCTTAGCTTGAACATTATTCACTTAGATTTCT
TCCAGTATTTTTTAAAAAACTGTCCTATCTCATTTTAAAAGACTTTCTTTTGCTTGATCCCAATGACTGTTTGAATGCTTATATATTTGT
TCAATCTGTTGATAGAAAAAATTGTTCATTTTCCTCAGTCTCAAATTTATAAATATTTGCTTACAGTTTTCCTATTCAAACAATTTGTTA
GGCCAATATTTTGTGACATTTTTGTAGCGATTTTAACGTTTATGGTTTTGGTTCTACAGGAAAGTCATAAATATTTAAAGGCCTTAAACA
TGTATGTACTTTTTTTTTCTAAGTTATAGAATGTATAATTTTGTACTACATTTATTTTGTTTCATTTGTGATATGAAGGGAGAGAAGAAA
GAAAAGTGCATAGCCATTCTGTAACAATATTGTGTAAACCTATAGTTTGAAGGAATGCAAGGAGAAGGATTTCTGTGTTTTACTCATTTT
AGGCTGTTCAGAAGATGCTTCAAAAATTGTCCTGTTAGAATTTCCATCATGGAAGGTGGTATGGAAGAAGGTATGGAAATACTTTGTATT
CTAAAAACTCACTGACGTGGTCAGTTAGACATACGTTGGTTTCCAGGATAGAGGCCCATATATCCTGGGGAGCTTTGGTCTATTAGTTTG
TGACAATATTCAAAGGCCAAAACACTACTCAGACACTTTCCTGGGAAGAGCAACTAAAAATGTAAAATTGGTTAAAAATAAAATCTGAAA
AGTATGTATCTCACATTGAACTAAAATCCACTGTCTCATAAGTTCATGGAATGAAATGGCTTTCTGCCTCCATTTTAATCATGCATAAAA
TGAATTAGATGGCTTTGAGTGGATTTTCACAATGGCTCAAGACTATATGAAATTATAAAAAAAAAGTTGCCCTGGGGTTTCTGCATCAAT
TAGAATATCATTAATTTCTTTGTAACCAAGTGAAAAACTATACTTTTTGGAAATTATGAATTTGTCCTAGGTTTGTTTGAGATTTGAAAT
TATACATCATGCTTCTCATTTTTTAAACTATGTTCTTTAAATCAACACTGGAAACTCTGTATTATATACAAGTGTAATACATGCATATAA
TAGAAAAAAAACATGGAATTTCAAATATACTAACTAGATTATCCCCAGTAGATTAATGTTGTGACTATTCAGAAAAGGTGAATAAAATTG

>49743_49743_1_LRP1-FAM19A2_LRP1_chr12_57569488_ENST00000243077_FAM19A2_chr12_62104198_ENST00000550003_length(amino acids)=1286AA_BP=
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDG
PKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGR
LYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQV
GTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ
HTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQF
TCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLD
GLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPP
DKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGW

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Fusion Gene PPI Analysis for LRP1-FAM19A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLRP1chr12:57569488chr12:62104198ENST00000243077+23894445_45441264.33333333333334545.0MAFB


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRP1-FAM19A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRP1-FAM19A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource