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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LRP4-DDB2 (FusionGDB2 ID:49775)

Fusion Gene Summary for LRP4-DDB2

Fusion gene summary

Fusion gene information	Fusion gene name: LRP4-DDB2
	Fusion gene ID: 49775
		Hgene	Tgene
	Gene symbol	LRP4	DDB2
	Gene ID	4038	1643
	Gene name	LDL receptor related protein 4	damage specific DNA binding protein 2
	Synonyms	CLSS\|CMS17\|LRP-4\|LRP10\|MEGF7\|SOST2	DDBB\|UV-DDB2\|XPE
	Cytomap	11p11.2	11p11.2
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 4multiple epidermal growth factor-like domains 7	DNA damage-binding protein 2DDB p48 subunitUV-DDB 2UV-damaged DNA-binding protein 2damage-specific DNA binding protein 2, 48kDaxeroderma pigmentosum group E protein
	Modification date	20200313	20200327
	UniProtAcc	O75096	Q92466
	Ensembl transtripts involved in fusion gene	ENST00000378623,	ENST00000378601, ENST00000256996, ENST00000378600, ENST00000378603,
Fusion gene scores	* DoF score	7 X 7 X 7=343	12 X 6 X 7=504
	# samples	7	11
	** MAII score	log2(7/343*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LRP4 [Title/Abstract] AND DDB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LRP4(46914523)-DDB2(47260350), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LRP4	GO:0001822	kidney development	20381006
Hgene	LRP4	GO:0060173	limb development	20381006
Hgene	LRP4	GO:0090090	negative regulation of canonical Wnt signaling pathway	20093106
Tgene	DDB2	GO:0000209	protein polyubiquitination	12732143
Tgene	DDB2	GO:0009411	response to UV	12732143
Tgene	DDB2	GO:0035518	histone H2A monoubiquitination	22334663
Tgene	DDB2	GO:0051865	protein autoubiquitination	12732143
Tgene	DDB2	GO:0070914	UV-damage excision repair	22334663

Fusion gene breakpoints across LRP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-A6-6780	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+

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Fusion Gene ORF analysis for LRP4-DDB2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000378623	ENST00000378601	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+
In-frame	ENST00000378623	ENST00000256996	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+
In-frame	ENST00000378623	ENST00000378600	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+
In-frame	ENST00000378623	ENST00000378603	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378623	LRP4	chr11	46914523	-	ENST00000378600	DDB2	chr11	47260350	+	2357	1940	243	2159	638
ENST00000378623	LRP4	chr11	46914523	-	ENST00000378603	DDB2	chr11	47260350	+	2357	1940	243	2159	638
ENST00000378623	LRP4	chr11	46914523	-	ENST00000256996	DDB2	chr11	47260350	+	2357	1940	243	2159	638

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378623	ENST00000378600	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+	0.006373377	0.9936266
ENST00000378623	ENST00000378603	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+	0.006373377	0.9936266
ENST00000378623	ENST00000256996	LRP4	chr11	46914523	-	DDB2	chr11	47260350	+	0.006373377	0.9936266

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Fusion Genomic Features for LRP4-DDB2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LRP4	chr11	46914523	-	DDB2	chr11	47260350	+	0.02710841	0.9728916
LRP4	chr11	46914523	-	DDB2	chr11	47260350	+	0.02710841	0.9728916

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRP4-DDB2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46914523/chr11:47260350)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP4 O75096	DDB2 Q92466
FUNCTION: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). {ECO:0000250\|UniProtKB:Q8VI56, ECO:0000269\|PubMed:20381006, ECO:0000269\|PubMed:21471202}.	FUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:9892649, PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386, PubMed:14751237). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed:10882109, PubMed:11278856, PubMed:11705987, PubMed:16260596, PubMed:12944386). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed:12732143, PubMed:15882621, PubMed:16473935, PubMed:18593899, PubMed:26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed:16678110, PubMed:16473935). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed:16678110, PubMed:16473935). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed:15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed:26572825). {ECO:0000269\|PubMed:10882109, ECO:0000269\|PubMed:11278856, ECO:0000269\|PubMed:11705987, ECO:0000269\|PubMed:12732143, ECO:0000269\|PubMed:12944386, ECO:0000269\|PubMed:14751237, ECO:0000269\|PubMed:15882621, ECO:0000269\|PubMed:16260596, ECO:0000269\|PubMed:16473935, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:18593899, ECO:0000269\|PubMed:26572825, ECO:0000269\|PubMed:9892649}.; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. {ECO:0000269\|PubMed:14751237}.; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. {ECO:0000269\|PubMed:14751237}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

109_144

565

1906.0

Domain

LDL-receptor class A 3

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

147_183

565

1906.0

Domain

LDL-receptor class A 4

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

190_226

565

1906.0

Domain

LDL-receptor class A 5

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

230_266

565

1906.0

Domain

LDL-receptor class A 6

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

269_305

565

1906.0

Domain

LDL-receptor class A 7

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

26_67

565

1906.0

Domain

LDL-receptor class A 1

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

311_350

565

1906.0

Domain

LDL-receptor class A 8

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

354_394

565

1906.0

Domain

EGF-like 1%3B calcium-binding

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

395_434

565

1906.0

Domain

EGF-like 2%3B calcium-binding

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

70_106

565

1906.0

Domain

LDL-receptor class A 2

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

480_522

565

1906.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

523_565

565

1906.0

Repeat

Note=LDL-receptor class B 2

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

256_274

222

239.0

Motif

Note=DWD box

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

334_336

222

239.0

Region

Note=Photolesion recognition

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

244_287

222

239.0

Repeat

WD 4

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

290_329

222

239.0

Repeat

WD 5

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

343_386

222

239.0

Repeat

WD 6

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

396_420

222

239.0

Repeat

WD 7

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

396_420

352

237.33333333333334

Repeat

WD 7

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

396_420

347

364.0

Repeat

WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

698_737

565

1906.0

Domain

Note=EGF-like 3

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1766_1769

565

1906.0

Motif

Endocytosis signal

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1093_1135

565

1906.0

Repeat

Note=LDL-receptor class B 11

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1136_1178

565

1906.0

Repeat

Note=LDL-receptor class B 12

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1179_1222

565

1906.0

Repeat

Note=LDL-receptor class B 13

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1223_1263

565

1906.0

Repeat

Note=LDL-receptor class B 14

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1264_1306

565

1906.0

Repeat

Note=LDL-receptor class B 15

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1397_1439

565

1906.0

Repeat

Note=LDL-receptor class B 16

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1440_1482

565

1906.0

Repeat

Note=LDL-receptor class B 17

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1483_1526

565

1906.0

Repeat

Note=LDL-receptor class B 18

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1527_1568

565

1906.0

Repeat

Note=LDL-receptor class B 19

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1569_1610

565

1906.0

Repeat

Note=LDL-receptor class B 20

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

566_609

565

1906.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

610_652

565

1906.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

653_693

565

1906.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

785_827

565

1906.0

Repeat

Note=LDL-receptor class B 6

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

828_870

565

1906.0

Repeat

Note=LDL-receptor class B 7

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

871_914

565

1906.0

Repeat

Note=LDL-receptor class B 8

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

915_956

565

1906.0

Repeat

Note=LDL-receptor class B 9

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

957_998

565

1906.0

Repeat

Note=LDL-receptor class B 10

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1747_1905

565

1906.0

Topological domain

Cytoplasmic

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

21_1725

565

1906.0

Topological domain

Extracellular

Hgene

LRP4

chr11:46914523

chr11:47260350

ENST00000378623

1726_1746

565

1906.0

Transmembrane

Helical

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

256_274

411

428.0

Motif

Note=DWD box

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

256_274

352

237.33333333333334

Motif

Note=DWD box

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

256_274

347

364.0

Motif

Note=DWD box

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

334_336

411

428.0

Region

Note=Photolesion recognition

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

334_336

352

237.33333333333334

Region

Note=Photolesion recognition

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

334_336

347

364.0

Region

Note=Photolesion recognition

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

116_151

411

428.0

Repeat

WD 1

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

159_194

411

428.0

Repeat

WD 2

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

203_238

411

428.0

Repeat

WD 3

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

244_287

411

428.0

Repeat

WD 4

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

290_329

411

428.0

Repeat

WD 5

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

343_386

411

428.0

Repeat

WD 6

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000256996

396_420

411

428.0

Repeat

WD 7

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

116_151

222

239.0

Repeat

WD 1

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

159_194

222

239.0

Repeat

WD 2

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378600

203_238

222

239.0

Repeat

WD 3

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

116_151

352

237.33333333333334

Repeat

WD 1

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

159_194

352

237.33333333333334

Repeat

WD 2

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

203_238

352

237.33333333333334

Repeat

WD 3

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

244_287

352

237.33333333333334

Repeat

WD 4

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

290_329

352

237.33333333333334

Repeat

WD 5

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378601

343_386

352

237.33333333333334

Repeat

WD 6

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

116_151

347

364.0

Repeat

WD 1

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

159_194

347

364.0

Repeat

WD 2

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

203_238

347

364.0

Repeat

WD 3

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

244_287

347

364.0

Repeat

WD 4

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

290_329

347

364.0

Repeat

WD 5

Tgene

DDB2

chr11:46914523

chr11:47260350

ENST00000378603

343_386

347

364.0

Repeat

WD 6

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Fusion Gene Sequence for LRP4-DDB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>49775_49775_1_LRP4-DDB2_LRP4_chr11_46914523_ENST00000378623_DDB2_chr11_47260350_ENST00000256996_length(transcript)=2357nt_BP=1940nt
GTGGCCGGGGCTGCGGCGCGGGGGGCGGGGCGGTCGGGCCCGGGACACCCCCTCCCGGTCCCCTGGCGGGGCAGCGTCGGCTCTGGCAGC
ACTGGAGGCGGCGGCGGCCCGAGGGCGACTTGCGGGGCGCGCAGGCCGCCGTGCACCCGGGACGCTTCCCCCTCGGGGACCCTCCGCGGG
CTTCTCCGCCGCGCCGTCCGGCGGGAGCCGGCGGGACCCCGGGCGAGCGGCGCGGGCGGCACCATGAGGCGGCAGTGGGGCGCGCTGCTG
CTTGGCGCCCTGCTCTGCGCACACGGCCTGGCCAGCAGCCCCGAGTGTGCTTGTGGTCGGAGCCACTTCACATGTGCAGTGAGTGCTCTT
GGAGAGTGTACCTGCATCCCTGCCCAGTGGCAGTGTGATGGAGACAATGACTGCGGGGACCACAGCGATGAGGATGGATGTATACTACCT
ACCTGTTCCCCTCTTGACTTTCACTGTGACAATGGCAAGTGCATCCGCCGCTCCTGGGTGTGTGACGGGGACAACGACTGTGAGGATGAC
TCGGATGAGCAGGACTGTCCCCCCCGGGAGTGTGAGGAGGACGAGTTTCCCTGCCAGAATGGCTACTGCATCCGGAGTCTGTGGCACTGC
GATGGTGACAATGACTGTGGCGACAACAGCGATGAGCAGTGTGACATGCGCAAGTGCTCCGACAAGGAGTTCCGCTGTAGTGACGGAAGC
TGCATTGCTGAGCATTGGTACTGCGACGGTGACACCGACTGCAAAGATGGCTCCGATGAGGAGAACTGTCCCTCAGCAGTGCCAGCGCCC
CCCTGCAACCTGGAGGAGTTCCAGTGTGCCTATGGACGCTGCATCCTCGACATCTACCACTGCGATGGCGACGATGACTGTGGAGACTGG
TCAGACGAGTCTGACTGCTCCTCCCACCAGCCCTGCCGCTCTGGGGAGTTCATGTGTGACAGTGGCCTGTGCATCAATGCAGGCTGGCGC
TGCGATGGTGACGCGGACTGTGATGACCAGTCTGATGAGCGCAACTGCACCACCTCCATGTGTACGGCAGAACAGTTCCGCTGTCACTCA
GGCCGCTGTGTCCGCCTGTCCTGGCGCTGTGATGGGGAGGACGACTGTGCAGACAACAGCGATGAAGAGAACTGTGAGAATACAGGAAGC
CCCCAATGTGCCTTGGACCAGTTCCTGTGTTGGAATGGGCGCTGCATTGGGCAGAGGAAGCTGTGCAACGGGGTCAACGACTGTGGTGAC
AACAGCGACGAAAGCCCACAGCAGAATTGCCGGCCCCGGACGGGTGAGGAGAACTGCAATGTTAACAACGGTGGCTGTGCCCAGAAGTGC
CAGATGGTGCGGGGGGCAGTGCAGTGTACCTGCCACACAGGCTACCGGCTCACAGAGGATGGGCACACGTGCCAAGATGTGAATGAATGT
GCCGAGGAGGGGTATTGCAGCCAGGGCTGCACCAACAGCGAAGGGGCTTTCCAATGCTGGTGTGAAACAGGCTATGAACTACGGCCCGAC
CGGCGCAGCTGCAAGGCTCTGGGGCCAGAGCCTGTGCTGCTGTTCGCCAATCGCATCGACATCCGGCAGGTGCTGCCACACCGCTCTGAG
TACACACTGCTGCTTAACAACCTGGAGAATGCCATTGCCCTTGATTTCCACCACCGCCGCGAGCTTGTCTTCTGGTCAGATGTCACCCTG
GACCGGATCCTCCGTGCCAACCTCAACGGCAGCAACGTGGAGGAGGTTGTGTCTACTGGGCTGGAGAGCCCAGGGGGCCTGGCTGTGGAT
TGGGTCCATGACAAACTCTACTGGACCGACTCAGGCACCTCGAGGATTGAGGTGGCCAATCTGGATGGGGCCCACCGGAAAGTGTTGCTG
TGGCAGAACCTGGAGAAGCCCCGGGCCATTGCCTTGCATCCCATGGAGGGGTTACCACATTCTCATCTGGAGCCAGGAGGAAGCCAGGAC
ACGGAAGTGAGAGACACTAAAGAAGGTGTGGGCCAGACAAGGCCTTGGAGCCCACACATGGGATCAAGTCCTGCAAGCAGAGGTGGCGAT
TTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGGTTGGAGCAGGGGTGCTGGGACCTGGGGCACTGTGGGACTGGGACACTTTTATGTTAA
TGCTCTGGACTTGCCTCCAGAGACTGCTCCAGAGTTGGTGACACAGCTGTCCCAAGGGCCCCTCTGTATCTAGCCTGGAACCAAGGTTAT
CTTGGAACTAAATGACTTTTCTCCTCTCAGTGGGTGGTAGCAGAGGGATCAAGCAGTTATTTGATTTGTGCTCACTTTTGATATGGCCAA

>49775_49775_1_LRP4-DDB2_LRP4_chr11_46914523_ENST00000378623_DDB2_chr11_47260350_ENST00000256996_length(amino acids)=638AA_BP=566
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVC
DGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMC
TAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDI
RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
DGAHRKVLLWQNLEKPRAIALHPMEGLPHSHLEPGGSQDTEVRDTKEGVGQTRPWSPHMGSSPASRGGDLLKGQKYPRLGLEQGCWDLGH

--------------------------------------------------------------
>49775_49775_2_LRP4-DDB2_LRP4_chr11_46914523_ENST00000378623_DDB2_chr11_47260350_ENST00000378600_length(transcript)=2357nt_BP=1940nt
GTGGCCGGGGCTGCGGCGCGGGGGGCGGGGCGGTCGGGCCCGGGACACCCCCTCCCGGTCCCCTGGCGGGGCAGCGTCGGCTCTGGCAGC
ACTGGAGGCGGCGGCGGCCCGAGGGCGACTTGCGGGGCGCGCAGGCCGCCGTGCACCCGGGACGCTTCCCCCTCGGGGACCCTCCGCGGG
CTTCTCCGCCGCGCCGTCCGGCGGGAGCCGGCGGGACCCCGGGCGAGCGGCGCGGGCGGCACCATGAGGCGGCAGTGGGGCGCGCTGCTG
CTTGGCGCCCTGCTCTGCGCACACGGCCTGGCCAGCAGCCCCGAGTGTGCTTGTGGTCGGAGCCACTTCACATGTGCAGTGAGTGCTCTT
GGAGAGTGTACCTGCATCCCTGCCCAGTGGCAGTGTGATGGAGACAATGACTGCGGGGACCACAGCGATGAGGATGGATGTATACTACCT
ACCTGTTCCCCTCTTGACTTTCACTGTGACAATGGCAAGTGCATCCGCCGCTCCTGGGTGTGTGACGGGGACAACGACTGTGAGGATGAC
TCGGATGAGCAGGACTGTCCCCCCCGGGAGTGTGAGGAGGACGAGTTTCCCTGCCAGAATGGCTACTGCATCCGGAGTCTGTGGCACTGC
GATGGTGACAATGACTGTGGCGACAACAGCGATGAGCAGTGTGACATGCGCAAGTGCTCCGACAAGGAGTTCCGCTGTAGTGACGGAAGC
TGCATTGCTGAGCATTGGTACTGCGACGGTGACACCGACTGCAAAGATGGCTCCGATGAGGAGAACTGTCCCTCAGCAGTGCCAGCGCCC
CCCTGCAACCTGGAGGAGTTCCAGTGTGCCTATGGACGCTGCATCCTCGACATCTACCACTGCGATGGCGACGATGACTGTGGAGACTGG
TCAGACGAGTCTGACTGCTCCTCCCACCAGCCCTGCCGCTCTGGGGAGTTCATGTGTGACAGTGGCCTGTGCATCAATGCAGGCTGGCGC
TGCGATGGTGACGCGGACTGTGATGACCAGTCTGATGAGCGCAACTGCACCACCTCCATGTGTACGGCAGAACAGTTCCGCTGTCACTCA
GGCCGCTGTGTCCGCCTGTCCTGGCGCTGTGATGGGGAGGACGACTGTGCAGACAACAGCGATGAAGAGAACTGTGAGAATACAGGAAGC
CCCCAATGTGCCTTGGACCAGTTCCTGTGTTGGAATGGGCGCTGCATTGGGCAGAGGAAGCTGTGCAACGGGGTCAACGACTGTGGTGAC
AACAGCGACGAAAGCCCACAGCAGAATTGCCGGCCCCGGACGGGTGAGGAGAACTGCAATGTTAACAACGGTGGCTGTGCCCAGAAGTGC
CAGATGGTGCGGGGGGCAGTGCAGTGTACCTGCCACACAGGCTACCGGCTCACAGAGGATGGGCACACGTGCCAAGATGTGAATGAATGT
GCCGAGGAGGGGTATTGCAGCCAGGGCTGCACCAACAGCGAAGGGGCTTTCCAATGCTGGTGTGAAACAGGCTATGAACTACGGCCCGAC
CGGCGCAGCTGCAAGGCTCTGGGGCCAGAGCCTGTGCTGCTGTTCGCCAATCGCATCGACATCCGGCAGGTGCTGCCACACCGCTCTGAG
TACACACTGCTGCTTAACAACCTGGAGAATGCCATTGCCCTTGATTTCCACCACCGCCGCGAGCTTGTCTTCTGGTCAGATGTCACCCTG
GACCGGATCCTCCGTGCCAACCTCAACGGCAGCAACGTGGAGGAGGTTGTGTCTACTGGGCTGGAGAGCCCAGGGGGCCTGGCTGTGGAT
TGGGTCCATGACAAACTCTACTGGACCGACTCAGGCACCTCGAGGATTGAGGTGGCCAATCTGGATGGGGCCCACCGGAAAGTGTTGCTG
TGGCAGAACCTGGAGAAGCCCCGGGCCATTGCCTTGCATCCCATGGAGGGGTTACCACATTCTCATCTGGAGCCAGGAGGAAGCCAGGAC
ACGGAAGTGAGAGACACTAAAGAAGGTGTGGGCCAGACAAGGCCTTGGAGCCCACACATGGGATCAAGTCCTGCAAGCAGAGGTGGCGAT
TTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGGTTGGAGCAGGGGTGCTGGGACCTGGGGCACTGTGGGACTGGGACACTTTTATGTTAA
TGCTCTGGACTTGCCTCCAGAGACTGCTCCAGAGTTGGTGACACAGCTGTCCCAAGGGCCCCTCTGTATCTAGCCTGGAACCAAGGTTAT
CTTGGAACTAAATGACTTTTCTCCTCTCAGTGGGTGGTAGCAGAGGGATCAAGCAGTTATTTGATTTGTGCTCACTTTTGATATGGCCAA

>49775_49775_2_LRP4-DDB2_LRP4_chr11_46914523_ENST00000378623_DDB2_chr11_47260350_ENST00000378600_length(amino acids)=638AA_BP=566
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVC
DGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMC
TAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDI
RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
DGAHRKVLLWQNLEKPRAIALHPMEGLPHSHLEPGGSQDTEVRDTKEGVGQTRPWSPHMGSSPASRGGDLLKGQKYPRLGLEQGCWDLGH

--------------------------------------------------------------
>49775_49775_3_LRP4-DDB2_LRP4_chr11_46914523_ENST00000378623_DDB2_chr11_47260350_ENST00000378603_length(transcript)=2357nt_BP=1940nt
GTGGCCGGGGCTGCGGCGCGGGGGGCGGGGCGGTCGGGCCCGGGACACCCCCTCCCGGTCCCCTGGCGGGGCAGCGTCGGCTCTGGCAGC
ACTGGAGGCGGCGGCGGCCCGAGGGCGACTTGCGGGGCGCGCAGGCCGCCGTGCACCCGGGACGCTTCCCCCTCGGGGACCCTCCGCGGG
CTTCTCCGCCGCGCCGTCCGGCGGGAGCCGGCGGGACCCCGGGCGAGCGGCGCGGGCGGCACCATGAGGCGGCAGTGGGGCGCGCTGCTG
CTTGGCGCCCTGCTCTGCGCACACGGCCTGGCCAGCAGCCCCGAGTGTGCTTGTGGTCGGAGCCACTTCACATGTGCAGTGAGTGCTCTT
GGAGAGTGTACCTGCATCCCTGCCCAGTGGCAGTGTGATGGAGACAATGACTGCGGGGACCACAGCGATGAGGATGGATGTATACTACCT
ACCTGTTCCCCTCTTGACTTTCACTGTGACAATGGCAAGTGCATCCGCCGCTCCTGGGTGTGTGACGGGGACAACGACTGTGAGGATGAC
TCGGATGAGCAGGACTGTCCCCCCCGGGAGTGTGAGGAGGACGAGTTTCCCTGCCAGAATGGCTACTGCATCCGGAGTCTGTGGCACTGC
GATGGTGACAATGACTGTGGCGACAACAGCGATGAGCAGTGTGACATGCGCAAGTGCTCCGACAAGGAGTTCCGCTGTAGTGACGGAAGC
TGCATTGCTGAGCATTGGTACTGCGACGGTGACACCGACTGCAAAGATGGCTCCGATGAGGAGAACTGTCCCTCAGCAGTGCCAGCGCCC
CCCTGCAACCTGGAGGAGTTCCAGTGTGCCTATGGACGCTGCATCCTCGACATCTACCACTGCGATGGCGACGATGACTGTGGAGACTGG
TCAGACGAGTCTGACTGCTCCTCCCACCAGCCCTGCCGCTCTGGGGAGTTCATGTGTGACAGTGGCCTGTGCATCAATGCAGGCTGGCGC
TGCGATGGTGACGCGGACTGTGATGACCAGTCTGATGAGCGCAACTGCACCACCTCCATGTGTACGGCAGAACAGTTCCGCTGTCACTCA
GGCCGCTGTGTCCGCCTGTCCTGGCGCTGTGATGGGGAGGACGACTGTGCAGACAACAGCGATGAAGAGAACTGTGAGAATACAGGAAGC
CCCCAATGTGCCTTGGACCAGTTCCTGTGTTGGAATGGGCGCTGCATTGGGCAGAGGAAGCTGTGCAACGGGGTCAACGACTGTGGTGAC
AACAGCGACGAAAGCCCACAGCAGAATTGCCGGCCCCGGACGGGTGAGGAGAACTGCAATGTTAACAACGGTGGCTGTGCCCAGAAGTGC
CAGATGGTGCGGGGGGCAGTGCAGTGTACCTGCCACACAGGCTACCGGCTCACAGAGGATGGGCACACGTGCCAAGATGTGAATGAATGT
GCCGAGGAGGGGTATTGCAGCCAGGGCTGCACCAACAGCGAAGGGGCTTTCCAATGCTGGTGTGAAACAGGCTATGAACTACGGCCCGAC
CGGCGCAGCTGCAAGGCTCTGGGGCCAGAGCCTGTGCTGCTGTTCGCCAATCGCATCGACATCCGGCAGGTGCTGCCACACCGCTCTGAG
TACACACTGCTGCTTAACAACCTGGAGAATGCCATTGCCCTTGATTTCCACCACCGCCGCGAGCTTGTCTTCTGGTCAGATGTCACCCTG
GACCGGATCCTCCGTGCCAACCTCAACGGCAGCAACGTGGAGGAGGTTGTGTCTACTGGGCTGGAGAGCCCAGGGGGCCTGGCTGTGGAT
TGGGTCCATGACAAACTCTACTGGACCGACTCAGGCACCTCGAGGATTGAGGTGGCCAATCTGGATGGGGCCCACCGGAAAGTGTTGCTG
TGGCAGAACCTGGAGAAGCCCCGGGCCATTGCCTTGCATCCCATGGAGGGGTTACCACATTCTCATCTGGAGCCAGGAGGAAGCCAGGAC
ACGGAAGTGAGAGACACTAAAGAAGGTGTGGGCCAGACAAGGCCTTGGAGCCCACACATGGGATCAAGTCCTGCAAGCAGAGGTGGCGAT
TTGTTAAAGGGCCAAAAGTATCCAAGGTTAGGGTTGGAGCAGGGGTGCTGGGACCTGGGGCACTGTGGGACTGGGACACTTTTATGTTAA
TGCTCTGGACTTGCCTCCAGAGACTGCTCCAGAGTTGGTGACACAGCTGTCCCAAGGGCCCCTCTGTATCTAGCCTGGAACCAAGGTTAT
CTTGGAACTAAATGACTTTTCTCCTCTCAGTGGGTGGTAGCAGAGGGATCAAGCAGTTATTTGATTTGTGCTCACTTTTGATATGGCCAA

>49775_49775_3_LRP4-DDB2_LRP4_chr11_46914523_ENST00000378623_DDB2_chr11_47260350_ENST00000378603_length(amino acids)=638AA_BP=566
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWVC
DGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMC
TAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDI
RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
DGAHRKVLLWQNLEKPRAIALHPMEGLPHSHLEPGGSQDTEVRDTKEGVGQTRPWSPHMGSSPASRGGDLLKGQKYPRLGLEQGCWDLGH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LRP4-DDB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LRP4-DDB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LRP4-DDB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source