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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRP5-ATG16L2 (FusionGDB2 ID:49783)

Fusion Gene Summary for LRP5-ATG16L2

check button Fusion gene summary
Fusion gene informationFusion gene name: LRP5-ATG16L2
Fusion gene ID: 49783
HgeneTgene
Gene symbol

LRP5

ATG16L2

Gene ID

4041

89849

Gene nameLDL receptor related protein 5autophagy related 16 like 2
SynonymsBMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP-7|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2ATG16B|WDR80
Cytomap

11q13.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7autophagy-related protein 16-2APG16-like 2ATG16 autophagy related 16-like 2WD repeat-containing protein 80
Modification date2020032920200313
UniProtAcc

O75197

Q8NAA4

Ensembl transtripts involved in fusion geneENST00000294304, ENST00000529481, 
ENST00000451353, ENST00000321297, 
ENST00000534905, 
Fusion gene scores* DoF score36 X 25 X 12=108007 X 6 X 6=252
# samples 418
** MAII scorelog2(41/10800*10)=-4.71926359243275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRP5 [Title/Abstract] AND ATG16L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRP5(68207384)-ATG16L2(72539404), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRP5

GO:0008284

positive regulation of cell proliferation

9790987

HgeneLRP5

GO:0045840

positive regulation of mitotic nuclear division

9790987

HgeneLRP5

GO:0045893

positive regulation of transcription, DNA-templated

15035989|17955262

HgeneLRP5

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

HgeneLRP5

GO:0060070

canonical Wnt signaling pathway

11029007|12121999|12857724|15908424|24706814|25920554


check buttonFusion gene breakpoints across LRP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATG16L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-2561-01ALRP5chr11

68207384

-ATG16L2chr11

72539404

+
ChimerDB4GBMTCGA-06-2561-01ALRP5chr11

68207384

+ATG16L2chr11

72539404

+
ChimerDB4GBMTCGA-06-2561LRP5chr11

68207384

+ATG16L2chr11

72539403

+


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Fusion Gene ORF analysis for LRP5-ATG16L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000294304ENST00000451353LRP5chr11

68207384

+ATG16L2chr11

72539404

+
5CDS-intronENST00000294304ENST00000451353LRP5chr11

68207384

+ATG16L2chr11

72539403

+
Frame-shiftENST00000294304ENST00000321297LRP5chr11

68207384

+ATG16L2chr11

72539404

+
Frame-shiftENST00000294304ENST00000321297LRP5chr11

68207384

+ATG16L2chr11

72539403

+
In-frameENST00000294304ENST00000534905LRP5chr11

68207384

+ATG16L2chr11

72539404

+
In-frameENST00000294304ENST00000534905LRP5chr11

68207384

+ATG16L2chr11

72539403

+
intron-3CDSENST00000529481ENST00000321297LRP5chr11

68207384

+ATG16L2chr11

72539404

+
intron-3CDSENST00000529481ENST00000321297LRP5chr11

68207384

+ATG16L2chr11

72539403

+
intron-3CDSENST00000529481ENST00000534905LRP5chr11

68207384

+ATG16L2chr11

72539404

+
intron-3CDSENST00000529481ENST00000534905LRP5chr11

68207384

+ATG16L2chr11

72539403

+
intron-intronENST00000529481ENST00000451353LRP5chr11

68207384

+ATG16L2chr11

72539404

+
intron-intronENST00000529481ENST00000451353LRP5chr11

68207384

+ATG16L2chr11

72539403

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294304LRP5chr1168207384+ENST00000534905ATG16L2chr1172539404+5850459410647701554
ENST00000294304LRP5chr1168207384+ENST00000534905ATG16L2chr1172539403+5850459410647701554

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294304ENST00000534905LRP5chr1168207384+ATG16L2chr1172539404+0.0020700650.99792993
ENST00000294304ENST00000534905LRP5chr1168207384+ATG16L2chr1172539403+0.0020700650.99792993

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Fusion Genomic Features for LRP5-ATG16L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LRP5chr1168207384+ATG16L2chr1172539403+1.77E-081
LRP5chr1168207384+ATG16L2chr1172539403+1.77E-081
LRP5chr1168207384+ATG16L2chr1172539403+1.77E-081
LRP5chr1168207384+ATG16L2chr1172539403+1.77E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LRP5-ATG16L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68207384/chr11:72539404)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP5

O75197

ATG16L2

Q8NAA4

FUNCTION: Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:27228167, PubMed:16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity). {ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:11719191, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:15908424, ECO:0000269|PubMed:16252235, ECO:0000269|PubMed:24706814, ECO:0000269|PubMed:25920554, ECO:0000269|PubMed:27228167}.FUNCTION: May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. {ECO:0000250|UniProtKB:Q6KAU8}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231213_125414961616.0DomainNote=EGF-like 4
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231258_129614961616.0DomainLDL-receptor class A 1
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231297_133314961616.0DomainLDL-receptor class A 2
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231335_137114961616.0DomainLDL-receptor class A 3
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123295_33714961616.0DomainNote=EGF-like 1
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123601_64114961616.0DomainNote=EGF-like 2
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123902_94214961616.0DomainNote=EGF-like 3
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231213_125414961616.0DomainNote=EGF-like 4
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231258_129614961616.0DomainLDL-receptor class A 1
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231297_133314961616.0DomainLDL-receptor class A 2
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231335_137114961616.0DomainLDL-receptor class A 3
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123295_33714961616.0DomainNote=EGF-like 1
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123601_64114961616.0DomainNote=EGF-like 2
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123902_94214961616.0DomainNote=EGF-like 3
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+212332_28814961616.0RegionNote=Beta-propeller 1
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123341_60214961616.0RegionNote=Beta-propeller 2
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123644_90314961616.0RegionNote=Beta-propeller 3
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123945_121214961616.0RegionNote=Beta-propeller 4
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+212332_28814961616.0RegionNote=Beta-propeller 1
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123341_60214961616.0RegionNote=Beta-propeller 2
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123644_90314961616.0RegionNote=Beta-propeller 3
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123945_121214961616.0RegionNote=Beta-propeller 4
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231036_107814961616.0RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231079_112314961616.0RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231124_116414961616.0RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231165_120714961616.0RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123120_16214961616.0RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123123_12614961616.0RepeatNote=YWTD 2
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123163_20614961616.0RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123166_16914961616.0RepeatNote=YWTD 3
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123207_24714961616.0RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123248_29014961616.0RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123251_25414961616.0RepeatNote=YWTD 4
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123385_42714961616.0RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123388_39114961616.0RepeatNote=YWTD 5
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123428_47014961616.0RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123431_43414961616.0RepeatNote=YWTD 6
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123471_51414961616.0RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123474_47714961616.0RepeatNote=YWTD 7
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123515_55714961616.0RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123558_60014961616.0RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123559_56214961616.0RepeatNote=YWTD 8
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123687_72914961616.0RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123690_69314961616.0RepeatNote=YWTD 9
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123730_77214961616.0RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+212375_11914961616.0RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123773_81514961616.0RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+212378_8114961616.0RepeatNote=YWTD 1
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123816_85514961616.0RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123819_82214961616.0RepeatNote=YWTD 10
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123856_89814961616.0RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123859_86214961616.0RepeatNote=YWTD 11
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+2123989_103514961616.0RepeatNote=LDL-receptor class B 16
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231036_107814961616.0RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231079_112314961616.0RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231124_116414961616.0RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231165_120714961616.0RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123120_16214961616.0RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123123_12614961616.0RepeatNote=YWTD 2
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123163_20614961616.0RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123166_16914961616.0RepeatNote=YWTD 3
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123207_24714961616.0RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123248_29014961616.0RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123251_25414961616.0RepeatNote=YWTD 4
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123385_42714961616.0RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123388_39114961616.0RepeatNote=YWTD 5
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123428_47014961616.0RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123431_43414961616.0RepeatNote=YWTD 6
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123471_51414961616.0RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123474_47714961616.0RepeatNote=YWTD 7
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123515_55714961616.0RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123558_60014961616.0RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123559_56214961616.0RepeatNote=YWTD 8
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123687_72914961616.0RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123690_69314961616.0RepeatNote=YWTD 9
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123730_77214961616.0RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+212375_11914961616.0RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123773_81514961616.0RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+212378_8114961616.0RepeatNote=YWTD 1
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123816_85514961616.0RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123819_82214961616.0RepeatNote=YWTD 10
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123856_89814961616.0RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123859_86214961616.0RepeatNote=YWTD 11
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+2123989_103514961616.0RepeatNote=LDL-receptor class B 16
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+212332_138414961616.0Topological domainExtracellular
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+212332_138414961616.0Topological domainExtracellular
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231385_140714961616.0TransmembraneHelical
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231385_140714961616.0TransmembraneHelical
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318500_539490620.0RepeatWD 5
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318546_585490620.0RepeatWD 6
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318589_619490620.0RepeatWD 7
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318500_539490620.0RepeatWD 5
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318546_585490620.0RepeatWD 6
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318589_619490620.0RepeatWD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231495_161014961616.0Compositional biasNote=Pro-rich
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231495_161014961616.0Compositional biasNote=Pro-rich
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231500_150614961616.0MotifNote=PPPSP motif A
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231538_154514961616.0MotifNote=PPPSP motif B
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231574_158114961616.0MotifNote=PPPSP motif C
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231591_159614961616.0MotifNote=PPPSP motif D
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231605_161214961616.0MotifNote=PPPSP motif E
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231500_150614961616.0MotifNote=PPPSP motif A
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231538_154514961616.0MotifNote=PPPSP motif B
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231574_158114961616.0MotifNote=PPPSP motif C
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231591_159614961616.0MotifNote=PPPSP motif D
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231605_161214961616.0MotifNote=PPPSP motif E
HgeneLRP5chr11:68207384chr11:72539403ENST00000294304+21231408_161514961616.0Topological domainCytoplasmic
HgeneLRP5chr11:68207384chr11:72539404ENST00000294304+21231408_161514961616.0Topological domainCytoplasmic
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318116_227490620.0Coiled coilOntology_term=ECO:0000255
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318116_227490620.0Coiled coilOntology_term=ECO:0000255
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318334_373490620.0RepeatWD 1
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318378_417490620.0RepeatWD 2
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318420_454490620.0RepeatWD 3
TgeneATG16L2chr11:68207384chr11:72539403ENST000003212971318455_498490620.0RepeatWD 4
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318334_373490620.0RepeatWD 1
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318378_417490620.0RepeatWD 2
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318420_454490620.0RepeatWD 3
TgeneATG16L2chr11:68207384chr11:72539404ENST000003212971318455_498490620.0RepeatWD 4


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Fusion Gene Sequence for LRP5-ATG16L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49783_49783_1_LRP5-ATG16L2_LRP5_chr11_68207384_ENST00000294304_ATG16L2_chr11_72539403_ENST00000534905_length(transcript)=5850nt_BP=4594nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG
GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA
GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG
CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA
GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT
CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC
GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT
CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG
CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT
CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT
CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG
GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC
CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTTGATGGGAC
GAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGACTGGCAGCG
CCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAA
TGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCAACCCGGTG
TGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCAT
CCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTC
CAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTT
TGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGC
GCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACAT
CTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCG
GGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGG
TCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCT
GCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTT
CCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCG
CTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGC
CATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGA
CCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTC
TCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCAC
CAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAA
CGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGT
CCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCG
CATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAA
GCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGT
CGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTC
CCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGA
GCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGA
GTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCT
GCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAG
CGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCC
GCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTT
TGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCT
CAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGG
GGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCC
GCCGGGGGCCCCACTGCACCCAGGTCATCCCTGTGCAGGGCCGGGTCACCTCCCTGAGCCTCAGCCACGACCAACTGCACCTGCTCAGCT
GTTCCCGAGACAACACACTCAAGGTCATCGACCTGCGTGTCAGCAACATCCGCCAGGTGTTCAGGGCCGATGGCTTCAAGTGTGGTTCTG
ACTGGACCAAAGCTGTGTTCAGGTACCTGAATCTCTCTCATCCATGGAGTGTCACCATTTTCTGAGGCTGAAAGTTCTTCCACTAGCACC
GATGGGAAAACTCCAATACGCCCATTGAATTCCCCTTCCCAGAAGCCATCATCATCTTGGTTTTCTTTGTTCAAGATACGGATTATTGCT
CCCTCAGGAAAAGATAACTCATCATCTGTCTGGCCCTCATAATCATAAAGTGCTTTCACAAAACATACTAGGGAGCAAGAGAAAAACAAA
TCTGGTAAGATAATTAACAGCCGGTTGCTTTTGCAACCACCCCTATGCTCACATGACAACTAAAAGAGCATCATACAGAATAGGATTAAA
GTTGTAATTTTTTTACTCACTGATGAATGATTAACTTTAGGGTTCTACTGTGCAGGACAAACGTGACCATATAAAGAAAAGCATATTATA
GGACAGGAGGAAAGTTGTGCTTTTTATCCTACTGAAGGCTTACTCCAGGGCAATACAGTTTAGGTCAAACGTGACCAAATAAAGAGTGCC
TTGTTTCAGTCTTTACCACTGGCATCTCCGTTGAGGCTGCCTGAAACGAGTTCTGCTTCCGTGGAATTGCTGGACGTGTGTGACCGACTG
TCCAAAGCGGCCAGGGACTGCAGCATGCTCAGGAGGCTGTTCGAGGTGGGAAACTGTAGGTACTTTTCTGGCACATAACCCACTTGGCCA
ACTTTATTTCGAGCCTGGGTAAAAGACATGTGACAAAACAAGTTTACACACACAATTTAGACAGGGCACAACAAAGACCAAAACAAACTC
CTAAAAATGTCACAAGAAAGGGCGATATGAGCAAAGGAATATACCTTTACCCAGTCTTCCATATCTCCATCTTCAATCACTTCTAACACC
TCATGTTCCTCAATGGTCAACTCATCTGGTTGAGAAGCCTGCAGTGTAGGATGGTCATGGACAAAATTAAAAAGGTTAGATAAGGAGCAG
ATGTGAGCTGATCATGACAAAAACTGGGGATCAAAATATTGAAATGATTTTGAGAAACATGTTGAACATAAAAATTTAAATGCTGTAAAA

>49783_49783_1_LRP5-ATG16L2_LRP5_chr11_68207384_ENST00000294304_ATG16L2_chr11_72539403_ENST00000534905_length(amino acids)=1554AA_BP=74
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIG
LELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLT
IDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKF
IYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWI
DRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS
PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVL
IKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAP
GGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPGAPLHPGHPCAGPGHLPEPQPRPTAPAQLFPRQH

--------------------------------------------------------------
>49783_49783_2_LRP5-ATG16L2_LRP5_chr11_68207384_ENST00000294304_ATG16L2_chr11_72539404_ENST00000534905_length(transcript)=5850nt_BP=4594nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG
GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA
GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG
CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA
GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT
CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC
GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT
CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG
CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT
CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT
CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG
GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC
CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTTGATGGGAC
GAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGACTGGCAGCG
CCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAA
TGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCAACCCGGTG
TGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCAT
CCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTC
CAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTT
TGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGC
GCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACAT
CTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCG
GGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGG
TCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCT
GCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTT
CCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCG
CTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGC
CATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGA
CCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTC
TCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCAC
CAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAA
CGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGT
CCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCG
CATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAA
GCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGT
CGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTC
CCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGA
GCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGA
GTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCT
GCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAG
CGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCC
GCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTT
TGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCT
CAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGG
GGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCC
GCCGGGGGCCCCACTGCACCCAGGTCATCCCTGTGCAGGGCCGGGTCACCTCCCTGAGCCTCAGCCACGACCAACTGCACCTGCTCAGCT
GTTCCCGAGACAACACACTCAAGGTCATCGACCTGCGTGTCAGCAACATCCGCCAGGTGTTCAGGGCCGATGGCTTCAAGTGTGGTTCTG
ACTGGACCAAAGCTGTGTTCAGGTACCTGAATCTCTCTCATCCATGGAGTGTCACCATTTTCTGAGGCTGAAAGTTCTTCCACTAGCACC
GATGGGAAAACTCCAATACGCCCATTGAATTCCCCTTCCCAGAAGCCATCATCATCTTGGTTTTCTTTGTTCAAGATACGGATTATTGCT
CCCTCAGGAAAAGATAACTCATCATCTGTCTGGCCCTCATAATCATAAAGTGCTTTCACAAAACATACTAGGGAGCAAGAGAAAAACAAA
TCTGGTAAGATAATTAACAGCCGGTTGCTTTTGCAACCACCCCTATGCTCACATGACAACTAAAAGAGCATCATACAGAATAGGATTAAA
GTTGTAATTTTTTTACTCACTGATGAATGATTAACTTTAGGGTTCTACTGTGCAGGACAAACGTGACCATATAAAGAAAAGCATATTATA
GGACAGGAGGAAAGTTGTGCTTTTTATCCTACTGAAGGCTTACTCCAGGGCAATACAGTTTAGGTCAAACGTGACCAAATAAAGAGTGCC
TTGTTTCAGTCTTTACCACTGGCATCTCCGTTGAGGCTGCCTGAAACGAGTTCTGCTTCCGTGGAATTGCTGGACGTGTGTGACCGACTG
TCCAAAGCGGCCAGGGACTGCAGCATGCTCAGGAGGCTGTTCGAGGTGGGAAACTGTAGGTACTTTTCTGGCACATAACCCACTTGGCCA
ACTTTATTTCGAGCCTGGGTAAAAGACATGTGACAAAACAAGTTTACACACACAATTTAGACAGGGCACAACAAAGACCAAAACAAACTC
CTAAAAATGTCACAAGAAAGGGCGATATGAGCAAAGGAATATACCTTTACCCAGTCTTCCATATCTCCATCTTCAATCACTTCTAACACC
TCATGTTCCTCAATGGTCAACTCATCTGGTTGAGAAGCCTGCAGTGTAGGATGGTCATGGACAAAATTAAAAAGGTTAGATAAGGAGCAG
ATGTGAGCTGATCATGACAAAAACTGGGGATCAAAATATTGAAATGATTTTGAGAAACATGTTGAACATAAAAATTTAAATGCTGTAAAA

>49783_49783_2_LRP5-ATG16L2_LRP5_chr11_68207384_ENST00000294304_ATG16L2_chr11_72539404_ENST00000534905_length(amino acids)=1554AA_BP=74
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIG
LELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLT
IDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKF
IYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWI
DRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS
PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVL
IKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAP
GGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPGAPLHPGHPCAGPGHLPEPQPRPTAPAQLFPRQH

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Fusion Gene PPI Analysis for LRP5-ATG16L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRP5-ATG16L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRP5-ATG16L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource