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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:LRP5-LRP6 (FusionGDB2 ID:49805)

Fusion Gene Summary for LRP5-LRP6

Fusion gene summary

Fusion gene information	Fusion gene name: LRP5-LRP6
	Fusion gene ID: 49805
		Hgene	Tgene
	Gene symbol	LRP5	LRP6
	Gene ID	4041	4040
	Gene name	LDL receptor related protein 5	LDL receptor related protein 6
	Synonyms	BMND1\|EVR1\|EVR4\|HBM\|LR3\|LRP-5\|LRP-7\|LRP7\|OPPG\|OPS\|OPTA1\|PCLD4\|VBCH2	ADCAD2\|STHAG7
	Cytomap	11q13.2	12p13.2
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7	low-density lipoprotein receptor-related protein 6LRP-6
	Modification date	20200329	20200329
	UniProtAcc	O75197	O75581
	Ensembl transtripts involved in fusion gene	ENST00000294304, ENST00000529481,	ENST00000540415, ENST00000261349, ENST00000543091,
Fusion gene scores	* DoF score	36 X 25 X 12=10800	9 X 9 X 4=324
	# samples	41	10
	** MAII score	log2(41/10800*10)=-4.71926359243275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LRP5 [Title/Abstract] AND LRP6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LRP5(68115711)-LRP6(12356334), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LRP5	GO:0008284	positive regulation of cell proliferation	9790987
Hgene	LRP5	GO:0045840	positive regulation of mitotic nuclear division	9790987
Hgene	LRP5	GO:0045893	positive regulation of transcription, DNA-templated	15035989\|17955262
Hgene	LRP5	GO:0045944	positive regulation of transcription by RNA polymerase II	12857724
Hgene	LRP5	GO:0060070	canonical Wnt signaling pathway	11029007\|12121999\|12857724\|15908424\|24706814\|25920554
Tgene	LRP6	GO:0014029	neural crest formation	11029007
Tgene	LRP6	GO:0014033	neural crest cell differentiation	11029007
Tgene	LRP6	GO:0016055	Wnt signaling pathway	11357136
Tgene	LRP6	GO:0045944	positive regulation of transcription by RNA polymerase II	12857724
Tgene	LRP6	GO:0051091	positive regulation of DNA-binding transcription factor activity	14739301
Tgene	LRP6	GO:0060070	canonical Wnt signaling pathway	11448771\|11742004\|12121999\|14739301\|15271658\|15908424\|16263759\|16543246\|17239604\|19107203\|20059949\|20093106\|20137080
Tgene	LRP6	GO:0071901	negative regulation of protein serine/threonine kinase activity	19107203

Fusion gene breakpoints across LRP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	2397N	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-
ChimerDB4	Non-Cancer	61N	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-

Top

Fusion Gene ORF analysis for LRP5-LRP6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000294304	ENST00000540415	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-
In-frame	ENST00000294304	ENST00000261349	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-
In-frame	ENST00000294304	ENST00000543091	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-
intron-3CDS	ENST00000529481	ENST00000261349	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-
intron-3CDS	ENST00000529481	ENST00000543091	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-
intron-intron	ENST00000529481	ENST00000540415	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000294304

LRP5

chr11

68115711

ENST00000261349

LRP6

chr12

12356334

10088

594

106

4986

1626

ENST00000294304

LRP5

chr11

68115711

ENST00000543091

LRP6

chr12

12356334

4885

594

106

4851

1581

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000294304	ENST00000261349	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-	0.000123156	0.99987686
ENST00000294304	ENST00000543091	LRP5	chr11	68115711	+	LRP6	chr12	12356334	-	0.000797647	0.99920243

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Fusion Genomic Features for LRP5-LRP6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LRP5-LRP6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68115711/chr12:12356334)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP5 O75197	LRP6 O75581
FUNCTION: Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:27228167, PubMed:16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity). {ECO:0000250\|UniProtKB:Q91VN0, ECO:0000269\|PubMed:11336703, ECO:0000269\|PubMed:11448771, ECO:0000269\|PubMed:11719191, ECO:0000269\|PubMed:14731402, ECO:0000269\|PubMed:15778503, ECO:0000269\|PubMed:15908424, ECO:0000269\|PubMed:16252235, ECO:0000269\|PubMed:24706814, ECO:0000269\|PubMed:25920554, ECO:0000269\|PubMed:27228167}.	FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11357136, ECO:0000269\|PubMed:11448771, ECO:0000269\|PubMed:15778503, ECO:0000269\|PubMed:16341017, ECO:0000269\|PubMed:16513652, ECO:0000269\|PubMed:17326769, ECO:0000269\|PubMed:17400545, ECO:0000269\|PubMed:19107203, ECO:0000269\|PubMed:19293931, ECO:0000269\|PubMed:19801552}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

120_162

162

1616.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

123_126

162

1616.0

Repeat

Note=YWTD 2

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

75_119

162

1616.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

78_81

162

1616.0

Repeat

Note=YWTD 1

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1203_1244

149

1614.0

Domain

Note=EGF-like 4

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1248_1286

149

1614.0

Domain

LDL-receptor class A 1

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1287_1323

149

1614.0

Domain

LDL-receptor class A 2

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1325_1361

149

1614.0

Domain

LDL-receptor class A 3

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

282_324

149

1614.0

Domain

Note=EGF-like 1

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

588_628

149

1614.0

Domain

Note=EGF-like 2

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

889_930

149

1614.0

Domain

Note=EGF-like 3

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1487_1493

149

1614.0

Motif

Note=PPPSP motif A

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1527_1534

149

1614.0

Motif

Note=PPPSP motif B

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1568_1575

149

1614.0

Motif

Note=PPPSP motif C

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1588_1593

149

1614.0

Motif

Note=PPPSP motif D

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1603_1610

149

1614.0

Motif

Note=PPPSP motif E

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

328_589

149

1614.0

Region

Note=Beta-propeller 2

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

631_890

149

1614.0

Region

Note=Beta-propeller 3

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

933_1202

149

1614.0

Region

Note=Beta-propeller 4

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1026_1068

149

1614.0

Repeat

Note=LDL-receptor class B 17

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1069_1113

149

1614.0

Repeat

Note=LDL-receptor class B 18

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1114_1156

149

1614.0

Repeat

Note=LDL-receptor class B 19

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1157_1198

149

1614.0

Repeat

Note=LDL-receptor class B 20

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

150_193

149

1614.0

Repeat

Note=LDL-receptor class B 3

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

194_236

149

1614.0

Repeat

Note=LDL-receptor class B 4

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

237_276

149

1614.0

Repeat

Note=LDL-receptor class B 5

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

372_414

149

1614.0

Repeat

Note=LDL-receptor class B 6

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

415_457

149

1614.0

Repeat

Note=LDL-receptor class B 7

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

458_501

149

1614.0

Repeat

Note=LDL-receptor class B 8

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

502_542

149

1614.0

Repeat

Note=LDL-receptor class B 9

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

543_584

149

1614.0

Repeat

Note=LDL-receptor class B 10

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

674_716

149

1614.0

Repeat

Note=LDL-receptor class B 11

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

717_759

149

1614.0

Repeat

Note=LDL-receptor class B 12

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

760_802

149

1614.0

Repeat

Note=LDL-receptor class B 13

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

803_842

149

1614.0

Repeat

Note=LDL-receptor class B 14

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

843_885

149

1614.0

Repeat

Note=LDL-receptor class B 15

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

977_1025

149

1614.0

Repeat

Note=LDL-receptor class B 16

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1394_1613

149

1614.0

Topological domain

Cytoplasmic

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

1371_1393

149

1614.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1495_1610

162

1616.0

Compositional bias

Note=Pro-rich

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1213_1254

162

1616.0

Domain

Note=EGF-like 4

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1258_1296

162

1616.0

Domain

LDL-receptor class A 1

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1297_1333

162

1616.0

Domain

LDL-receptor class A 2

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1335_1371

162

1616.0

Domain

LDL-receptor class A 3

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

295_337

162

1616.0

Domain

Note=EGF-like 1

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

601_641

162

1616.0

Domain

Note=EGF-like 2

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

902_942

162

1616.0

Domain

Note=EGF-like 3

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1500_1506

162

1616.0

Motif

Note=PPPSP motif A

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1538_1545

162

1616.0

Motif

Note=PPPSP motif B

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1574_1581

162

1616.0

Motif

Note=PPPSP motif C

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1591_1596

162

1616.0

Motif

Note=PPPSP motif D

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1605_1612

162

1616.0

Motif

Note=PPPSP motif E

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

32_288

162

1616.0

Region

Note=Beta-propeller 1

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

341_602

162

1616.0

Region

Note=Beta-propeller 2

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

644_903

162

1616.0

Region

Note=Beta-propeller 3

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

945_1212

162

1616.0

Region

Note=Beta-propeller 4

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1036_1078

162

1616.0

Repeat

Note=LDL-receptor class B 17

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1079_1123

162

1616.0

Repeat

Note=LDL-receptor class B 18

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1124_1164

162

1616.0

Repeat

Note=LDL-receptor class B 19

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1165_1207

162

1616.0

Repeat

Note=LDL-receptor class B 20

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

163_206

162

1616.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

166_169

162

1616.0

Repeat

Note=YWTD 3

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

207_247

162

1616.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

248_290

162

1616.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

251_254

162

1616.0

Repeat

Note=YWTD 4

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

385_427

162

1616.0

Repeat

Note=LDL-receptor class B 6

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

388_391

162

1616.0

Repeat

Note=YWTD 5

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

428_470

162

1616.0

Repeat

Note=LDL-receptor class B 7

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

431_434

162

1616.0

Repeat

Note=YWTD 6

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

471_514

162

1616.0

Repeat

Note=LDL-receptor class B 8

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

474_477

162

1616.0

Repeat

Note=YWTD 7

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

515_557

162

1616.0

Repeat

Note=LDL-receptor class B 9

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

558_600

162

1616.0

Repeat

Note=LDL-receptor class B 10

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

559_562

162

1616.0

Repeat

Note=YWTD 8

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

687_729

162

1616.0

Repeat

Note=LDL-receptor class B 11

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

690_693

162

1616.0

Repeat

Note=YWTD 9

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

730_772

162

1616.0

Repeat

Note=LDL-receptor class B 12

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

773_815

162

1616.0

Repeat

Note=LDL-receptor class B 13

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

816_855

162

1616.0

Repeat

Note=LDL-receptor class B 14

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

819_822

162

1616.0

Repeat

Note=YWTD 10

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

856_898

162

1616.0

Repeat

Note=LDL-receptor class B 15

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

859_862

162

1616.0

Repeat

Note=YWTD 11

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

989_1035

162

1616.0

Repeat

Note=LDL-receptor class B 16

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1408_1615

162

1616.0

Topological domain

Cytoplasmic

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

32_1384

162

1616.0

Topological domain

Extracellular

Hgene

LRP5

chr11:68115711

chr12:12356334

ENST00000294304

1385_1407

162

1616.0

Transmembrane

Helical

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

20_275

149

1614.0

Region

Note=Beta-propeller 1

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

107_149

149

1614.0

Repeat

Note=LDL-receptor class B 2

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

63_106

149

1614.0

Repeat

Note=LDL-receptor class B 1

Tgene

LRP6

chr11:68115711

chr12:12356334

ENST00000261349

20_1370

149

1614.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for LRP5-LRP6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>49805_49805_1_LRP5-LRP6_LRP5_chr11_68115711_ENST00000294304_LRP6_chr12_12356334_ENST00000261349_length(transcript)=10088nt_BP=594nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAA
GATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGA
AGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGG
TTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAA
GTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGC
CACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCAC
TGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCAT
TTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGG
CTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAAT
TGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCT
CAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTG
GACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCC
AAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGTTATGAATACTGATGGCAC
TGGGAGACGAGTACTAGTGGAAGACAAAATTCCTCACATATTTGGATTTACTTTGTTGGGTGACTATGTTTACTGGACTGACTGGCAGAG
GCGTAGCATTGAAAGAGTTCATAAACGAAGTGCAGAGAGGGAAGTGATCATAGATCAGCTGCCTGACCTCATGGGCCTAAAGGCTACAAA
TGTTCATCGAGTGATTGGTTCCAACCCCTGTGCTGAGGAAAACGGGGGATGTAGCCATCTCTGCCTCTATAGACCTCAGGGCCTTCGCTG
TGCTTGCCCTATTGGCTTTGAACTCATCAGTGACATGAAGACCTGCATTGTCCCAGAGGCTTTCCTTTTGTTTTCACGGAGAGCAGATAT
CAGACGAATTTCTCTGGAAACAAACAATAATAATGTGGCTATTCCACTCACTGGTGTCAAAGAAGCTTCTGCTTTGGATTTTGATGTGAC
AGACAACCGAATTTATTGGACTGATATATCACTCAAGACCATCAGCAGAGCCTTTATGAATGGCAGTGCACTGGAACATGTGGTAGAATT
CGGCTTAGATTATCCAGAAGGCATGGCAGTAGACTGGCTTGGGAAGAACTTGTACTGGGCAGACACAGGAACGAATCGAATTGAGGTGTC
AAAGTTGGATGGGCAGCACCGACAAGTTTTGGTGTGGAAAGACCTAGATAGTCCCAGAGCTCTCGCGTTGGACCCTGCCGAAGGATTTAT
GTATTGGACTGAATGGGGTGGAAAACCTAAGATAGACAGAGCTGCAATGGATGGAAGTGAACGTACTACCTTAGTTCCAAATGTGGGGCG
GGCAAACGGCCTAACTATTGATTATGCTAAAAGGAGGCTTTATTGGACAGACCTGGACACCAACTTAATAGAATCTTCAAATATGCTTGG
GCTCAACCGTGAAGTTATAGCAGATGACTTGCCTCATCCTTTTGGCTTAACTCAGTACCAAGATTATATCTACTGGACGGACTGGAGCCG
ACGCAGCATTGAGCGTGCCAACAAAACCAGTGGCCAAAACCGCACCATCATTCAGGGCCATTTGGATTATGTGATGGACATCCTCGTCTT
TCACTCATCTCGACAGTCAGGGTGGAATGAATGTGCTTCCAGCAATGGGCACTGCTCCCACCTCTGCTTGGCTGTGCCAGTTGGGGGTTT
TGTTTGTGGATGCCCTGCCCACTACTCTCTTAATGCTGACAACAGGACTTGTAGTGCTCCTACGACTTTCCTGCTCTTCAGTCAAAAGAG
TGCCATCAACCGCATGGTGATTGATGAACAACAGAGCCCCGACATCATCCTTCCCATCCACAGCCTTCGGAATGTCCGGGCCATTGACTA
TGACCCACTGGACAAGCAACTCTATTGGATTGACTCACGACAAAACATGATCCGAAAGGCACAAGAAGATGGCAGCCAGGGCTTTACTGT
GGTTGTGAGCTCAGTTCCGAGTCAGAACCTGGAAATACAACCCTATGACCTCAGCATTGATATTTACAGCCGCTACATCTACTGGACTTG
TGAGGCTACCAATGTCATTAATGTGACAAGATTAGATGGGAGATCAGTTGGAGTGGTGCTGAAAGGCGAGCAGGACAGACCTCGAGCCGT
TGTGGTAAACCCAGAGAAAGGGTATATGTATTTTACCAATCTTCAGGAAAGGTCTCCTAAAATTGAACGGGCTGCTTTGGATGGGACAGA
ACGGGAGGTCCTCTTTTTCAGTGGCTTAAGTAAACCAATTGCTTTAGCCCTTGATAGCAGGCTGGGCAAGCTCTTTTGGGCTGATTCAGA
TCTCCGGCGAATTGAAAGCAGTGATCTCTCAGGTGCTAACCGGATAGTATTAGAAGACTCCAATATCTTGCAGCCTGTGGGACTTACTGT
GTTTGAAAACTGGCTCTATTGGATTGATAAACAGCAGCAAATGATTGAAAAAATTGACATGACAGGTCGAGAGGGTAGAACCAAAGTCCA
AGCTCGAATTGCCCAGCTTAGTGACATTCATGCAGTAAAGGAGCTGAACCTTCAAGAATACAGACAGCACCCTTGTGCTCAGGATAATGG
TGGCTGTTCACATATTTGTCTTGTAAAGGGGGATGGTACTACAAGGTGTTCTTGCCCCATGCACCTGGTTCTACTTCAAGATGAGCTATC
ATGTGGAGAACCTCCAACATGTTCTCCTCAGCAGTTTACTTGTTTCACGGGGGAAATTGACTGTATCCCTGTGGCTTGGCGGTGCGATGG
GTTTACTGAATGTGAAGACCACAGTGATGAACTCAATTGTCCTGTATGCTCAGAGTCCCAGTTCCAGTGTGCCAGTGGGCAGTGTATTGA
TGGTGCCCTCCGATGCAATGGAGATGCAAACTGCCAGGACAAATCAGATGAGAAGAACTGTGAAGTGCTTTGTTTAATTGATCAGTTCCG
CTGTGCCAATGGTCAGTGCATTGGAAAGCACAAGAAGTGTGATCATAATGTGGATTGCAGTGACAAGTCAGATGAACTGGATTGTTATCC
GACTGAAGAACCAGCACCACAGGCCACCAATACAGTTGGTTCTGTTATTGGCGTAATTGTCACCATTTTTGTGTCTGGAACTGTATACTT
TATCTGCCAGAGGATGTTGTGTCCACGTATGAAGGGAGATGGGGAAACTATGACTAATGACTATGTAGTTCATGGACCAGCTTCTGTGCC
TCTTGGTTATGTGCCACACCCAAGTTCTTTGTCAGGATCTCTTCCAGGAATGTCTCGAGGTAAATCAATGATCAGCTCCCTCAGTATCAT
GGGGGGAAGCAGTGGACCCCCCTATGACCGAGCCCATGTTACAGGAGCATCATCAAGTAGTTCTTCAAGCACCAAAGGCACTTACTTCCC
TGCAATTTTGAACCCTCCACCATCCCCAGCCACAGAGCGATCACATTACACTATGGAATTTGGATATTCTTCAAACAGTCCTTCCACTCA
TAGGTCATACAGCTACAGGCCATATAGCTACCGGCACTTTGCACCCCCCACCACACCCTGCAGCACAGATGTTTGTGACAGTGACTATGC
TCCTAGTCGGAGAATGACCTCAGTGGCAACAGCCAAGGGCTATACCAGTGACTTGAACTATGATTCAGAACCTGTGCCCCCACCTCCCAC
ACCCCGAAGCCAATACTTGTCAGCAGAGGAGAACTATGAAAGCTGCCCACCTTCTCCATACACAGAGAGGAGCTATTCTCATCACCTCTA
CCCACCGCCACCCTCTCCCTGTACAGACTCCTCCTGAGGAGGGGCCCTCCTCCTCTGACTGCCTCCAACGTAAAAATGTAAATATAAATT
TGGTTGAGATCTGGAGGGGGGGAGGGAGCTATTAGAGAAGGATGAGGCAGACCATGTACAGTTAAAATTATAAAATGGGGTAGGGAATAC
TGGAGATATTTGTACAGAAGAAAAGGATATTTATATATTTTCTTAAAACAGCAGATTTGCTGCTTGTGCCATAAAAGTTTGTATAAAAAA
AATTTGTACTAAAAGTTTTATTTTTGCAAACTAAATACACAAAGCATGCCTTAAACCCAGTGAAGCAACTGAGTACAAAGGAAACAGGAA
TAATAAAGGCATCACTGACCAGGAATATCTGGGCTTTATTGATACCAAAAATAAAAAAGAGGAAGAAGAAAAATTAAGTCCATCTCAGAG
CAGCAAACCATAGATACATGGATGTAGCCAGATAGCCTTCAGTTAACTAACATTTGAGGGCCAACAAGTAAGAAATGATGAAAGGAAAAA
AATGCAATTAATACTAACCTTGGACGAAGGGCTTTGTTTTCTCTAGGAATCCAACAGTGCTAGTGAGGAAAGTAGATATTTCTAAAAACC
CATTCTGGGTGTTGCTGTTGTAGGAGAGATCAGCCCTCTGGTAAGATGCCATGAAGCTGTGTGTGTGTGCAAGTCTCTGTCCCTACCTTT
AGAATCCATACCTCTGTCAAAATGAATTTTTTTCTCTAGGTATGTTTACCTTGCTGCCTCCTCCAGCAACTTGGTAAGTCATTTTGCTAA
GATACCATGATTTTTTTAAGCTGAAGCATTGACTAAATGGAATTTTCTAAATTAAACTTGATTTTAATATTTCTTCTAGCTCCATTCCCC
AGTAGGCTTAGCTCTTCAATTTGACTGCTGTTTTTGCATAATGATCAAAAGTTAGACATATTATTTCTCTTCTTCCAAGATTGTTTTAAT
GCTCATTAAAATGTCTTTTTACAACACATATAGACAATGTTTAAGAATTAAAAATTTAACCATTATGTTTTTGTTGTAAATCTCATATCC
TTGCACTACTTTCAGCATATATCACAGTACGAAATCATTTATATATATATATATATATATATATATATATATATATATATATATATATAT
ATTTTGTTTGTTTGTTTGTTTTCTGAGTAAAACATTTAAATATGTTCTGGTTAGAGACAATCTATTTAAAAAGATTTTTTTCTTATTAGG
ATTTTCCCTATATTAACAGTTTGTGATGTTTTCATGTTCTTTAGACCGGTTTTTCTCAGAATAATGTCTACATACATACCTCTTCTAATG
TGTGACATGAATTTAATATCTTTCTGTTACCCACTGTGAATGTTAGGCTGTTTTCAAATTATCCACAAATTATTCTTGTAATCACCCAAT
ATTTTTATGTGGGTCCTCTCTTACCCATTATGGATTAAGATAGTTTAACAAATTTAACAATGAGGATTAAATGAGAAGGCAAACTGTTAA
CTTCTCAGCTGTCAGAATTTGGGTGGAAGGGAATAATGGAAGCCTCTTTTGTGATCTGCCTGACCTGCTGTCATGTATGGTACTGGGGCT
GCTACATCTTGAGCTATCAGGGCTGACCTGTGGAATGATTCTAGCACTTGCTCTGCCACCTTGCCAGAAGTTCGTTTCCTGCTTTTTACA
CATGTGTAGCACTTCTCTGCTAAAATTGAATGGTTTTAAACTAATGTATTTTTAGCTTAAGAGGTGTTGGTCAGTTAATTATTGAATTTT
TTTTTTTTCTTTTTTAATTCTGTCTTGCCAAGGCCTCTCTGGGTTTCAGGGCCCAAGAGAAAACAGTGGAAGAAAGGATTCAGAATTTGG
GCAAGGGTGAAGTAACTGTTCATGCAAGTTAAAAATACCTAAGTAAAGTTTTTGAAGATAAAATTGTGGTTTCAGAATAATGCTGATTGT
TGGAGACTGTAAGAATCAGGTGCACTTGATTTTGCATATAAGCAAATGGTAAATCTATCAGAATCCTAAAACAGACAAGCATGAACTCTT
CCCATTGCTGGAACTAAGTGCCCACAGTGTCAGACAAAATGGACATTGAACTTGGATTCTGTGATACACAGGGCACTTGATGCTTAAATG
AAGATGGAAAGGTTAGCAATACCTGGGTGTCAGTTAGAATTTGAGAATTCTATATGTTTACATATTTAAATGTGCATCTTGATCTGGTGG
GCTTCCCATGTGGAGACTTGCACTCTAATTAACTAAGAAGAATATTGCCTTGTTGGATCTCAGTCCACGTGCTTGCACTGCGATGGCAAT
GGCCTCTTCTTCAAAATACTAATTTGTGTGCCAATTTGTTTAAAATTATTTGAAGGCAGTTCAGCCTAATCTCAGTGTTCTCTTTCTGGG
GTAGATGAGATGGATTCTTAATATTTCTGGGAGTACTTTTTAATGAGAGAATTGTCAAATTTGGAAAGATTTATTGAGCCTTAGGTTACA
TGGACAGTTAAGCTTAAGTAAACTGTATATTGATTATCAAACACAAGCTGTAATTGGAAAAGTTGAGAGGAAAAGCATGAGATCACAAAT
TAGGGGGAAAAAAGAAAAGGGATTTTTAAATTTGGTGTATTAAATTCATTGTCCAAGGGGGAAAATGAATAATGTTTCATTAGATTCCTT
ATATGCAAAAGTATTTATTTTGAACATGTGTCCTAAAATATATGCACTAACTGATGTGATTAAAATTGTCCAAGAAATAAACTTGAGCAT
AACATACTTTGTGTGCACCACAGTAAGCTATTCTGCATTGAAGTGGTCTTTTATAACTAAGGCCTGGACTTTGCTCCAACAGAGTCGTGG
TCTTCTGAATAGTGACTTAAGGAGTTTTGTTTGCTTAAGTCAGATAATAGCACATTCACAGGGAAACAAAGAGAGTTGGTGGATAGAATT
TTCTGACTATTAATTTTTCTTCCATGAAATTTTATTATGCCTTTGGCACTTTCTGCCACTCTTACAGCATATCACAAGATATCTGTTTAG
CAGAAGATTATGTAGTTACTTTAATTTTAATATAAAAGTAGCTTGTGATACATTACCAAGAGATCTCTGATTCTTTAGTAAGTTTGAGAA
CACCTATTCTACAGAGATGATAGGTACTTAGAAATGAAGACTTTAAAGTACATTTTAATCTAATATAGGCCAGTAATTGGGGGAAGGGGC
TTTGAGCAGTACAATTTTAAGATGATTTTGAGGGTTGTATTTCTTTATCATTTAAAAATATCCTAAAGTCAGTAATTTATATGAAGGAAA
CTCATTCATTATTGAAGGTATTAAAAATAGCCATCATCTGTATTAGGTAGCAGTTTTGGAGGATCATCTTTTTCTTTTGCTATAAAGCCC
TATTAATGAAGAATACTTCCAGTAGAGTTAATAGCTGTAGCTTACCTAGTGTGTTAATGAAGTGTGTTTATTTATGTGACTTGATACCAG
TAGTCATAATAGAGACTGAAGAGGTATGCGTTAAGCACGCCTACTTCTATGCAGTAAACAGGCTGCAGCTGCCTAGATTAGATTCTTAGA
AATGTCATATTTTGAATTGTTTTATTTCTTGTAGGGGAAGCTTTGTCCCACTTCATTCATTTGCATGCCATAGGAATTACATATTGGTTA
TCATTACGTATCTAACAAGATTCAGAAACAAAAATCTTGGACTTTTCACATCCGAAATATGTCAGCTCTTAATAAATGTGTGGTGCTTAA
GTCTACATATGGCATCCATAGTTGATTTAGAGTATGGATATGAGTGTGTTGACCAGTTATCAGTAGGTGGACAAATATTTGGGCATCTAC
AGATGAGACTATGCACTAAGTGTGGACTGAGTCCTAAAGAAGCTTATAGTCAGGTGTTGTTTAAAACATTATCAGAATTCTTAAACCCAA
GGAATTTAATTTTATTTGGTATTTCTTAAGCCTAAAATGAACCAAGAGAAAGATGATTTTAGAAAGTACTTGTAGTGAAAGATGATTTTA
GAAAGTACTTGTAGTGCATGTGTGGCTTCTGACTTTTGGGATGGCACCATTTTATAATAGTTTCAAAATTTAGCTTTTGAAATTCTCAAC
ATTTTATGGTAGAAGACTTTGGACCTCAAGTATAAAATTATACGTTTATAATTTTTTTAAAATTTAAATTATAAGTATTGTGAATTCACA
CTCTCAGGCTATTGTCTGACTTGATCTACGTCTCATAAAGCCTGTACCTGAGTGGAGTGGAAGGTGGAGTCTTAGGTTAATCAGTTACTG
ACTCTACCCTCACCCTCTTTCAATTGAGGTAAACTTTGCTGTTTTTCTTTTTCATAAAGCATTCTCAAATTGTTGAGTTTATTGCTGAAA
AAAATCTCCATGACTTTACAGATAGAATTACAAACTAAATGATGTCTTGTATTTAGAAGCAGAGTACAGACCTAACGAACTGTTAGATTC
TCCACCATCACTTAGGGTTTGCCCAGAAGCAACACCAGAGAATTACAGACAACGCGCTTTTGCTGAACTGTCCATTTTGGTGGTTGTGTT
TTTCAGTCAAATATAAGCAGGATGGGCGATAGAGATATATTTATATATAGATACATATTCTATATATCTAATGCCTAAATATGGGTATTA
AAGGGAAAATTTTTAAAGTCTGATTAAATCCAATATGACATGAAATTAAATATATGGATTAGTAAGGAAAAATGTTAAAAAGTAGAGAGG
ATACCAAGAAGATTAAACTGGACTAGCCTTATTTGCAAGTGAAGGATCTGGTGCTGCTTTCAGATGTTTATCTTTTATTTTTTTCCCTTA
AGCTTTAATCTTCGTCATTGTCTTAAAGTCAACTGGTGTTTCTTGTTCATTGACTTTGGTACGATGGTGCTTTGCAAGGATGTATTTATG
TTATAATGGCCAACATTTGGTCAGCCCTTGTCCACTTATTCACTTCCCTCCTTTTGTAAAATAAGTGCTTTAATTATAAACTGTATAAAA
ATACCTTGTATAAACCCCTTTTTTGATTATTACAATAAATAAGCTGAATTGTAACAAATGAAATTTGATTTTTGTAATAAAACAGTGGAA

>49805_49805_1_LRP5-LRP6_LRP5_chr11_68115711_ENST00000294304_LRP6_chr12_12356334_ENST00000261349_length(amino acids)=1626AA_BP=472
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGFMYWTDWGEVPKIERAG
MDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG
LREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTP
DFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR
KILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL
VEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIG
FELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP
EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLT
IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ
SGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDK
QLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPE
KGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWL
YWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPP
TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQ
CIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVP
HPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSY
RPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPS

--------------------------------------------------------------
>49805_49805_2_LRP5-LRP6_LRP5_chr11_68115711_ENST00000294304_LRP6_chr12_12356334_ENST00000543091_length(transcript)=4885nt_BP=594nt
GCCCGAGGGGGGAGGCGGAGGCGCCGGGAGCCGCGCGAGGAGCCGCCGCCGCCGCGCCATGGAGCCCGAGTGAGCGCGGCGCGGGCCCGT
CCGGCCGCCGGACAACATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTGCTGCTGCTGGCGCTGTGCGGCTG
CCCGGCCCCCGCCGCGGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC
CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA
GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG
CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT
CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAA
GATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGA
AGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGG
TTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAA
GTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGC
CACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCAC
TGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCAT
TTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGG
CTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAAT
TGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCT
CAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTG
GACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCC
AAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGTTATGAATACTGATGGCAC
TGGGAGACGAGTACTAGTGGAAGACAAAATTCCTCACATATTTGGATTTACTTTGTTGGGTGACTATGTTTACTGGACTGACTGGCAGAG
GCGTAGCATTGAAAGAGTTCATAAACGAAGTGCAGAGAGGGAAGTGATCATAGATCAGCTGCCTGACCTCATGGGCCTAAAGGCTACAAA
TGTTCATCGAGTGATTGGTTCCAACCCCTGTGCTGAGGAAAACGGGGGATGTAGCCATCTCTGCCTCTATAGACCTCAGGGCCTTCGCTG
TGCTTGCCCTATTGGCTTTGAACTCATCAGTGACATGAAGACCTGCATTGTCCCAGAGGCTTTCCTTTTGTTTTCACGGAGAGCAGATAT
CAGACGAATTTCTCTGGAAACAAACAATAATAATGTGGCTATTCCACTCACTGGTGTCAAAGAAGCTTCTGCTTTGGATTTTGATGTGAC
AGACAACCGAATTTATTGGACTGATATATCACTCAAGACCATCAGCAGAGCCTTTATGAATGGCAGTGCACTGGAACATGTGGTAGAATT
CGGCTTAGATTATCCAGAAGGCATGGCAGTAGACTGGCTTGGGAAGAACTTGTACTGGGCAGACACAGGAACGAATCGAATTGAGGTGTC
AAAGTTGGATGGGCAGCACCGACAAGTTTTGGTGTGGAAAGACCTAGATAGTCCCAGAGCTCTCGCGTTGGACCCTGCCGAAGGATTTAT
GTATTGGACTGAATGGGGTGGAAAACCTAAGATAGACAGAGCTGCAATGGATGGAAGTGAACGTACTACCTTAGTTCCAAATGTGGGGCG
GGCAAACGGCCTAACTATTGATTATGCTAAAAGGAGGCTTTATTGGACAGACCTGGACACCAACTTAATAGAATCTTCAAATATGCTTGG
GCTCAACCGTGAAGTTATAGCAGATGACTTGCCTCATCCTTTTGGCTTAACTCAGTACCAAGATTATATCTACTGGACGGACTGGAGCCG
ACGCAGCATTGAGCGTGCCAACAAAACCAGTGGCCAAAACCGCACCATCATTCAGGGCCATTTGGATTATGTGATGGACATCCTCGTCTT
TCACTCATCTCGACAGTCAGGGTGGAATGAATGTGCTTCCAGCAATGGGCACTGCTCCCACCTCTGCTTGGCTGTGCCAGTTGGGGGTTT
TGTTTGTGGATGCCCTGCCCACTACTCTCTTAATGCTGACAACAGGACTTGTAGTGCTCCTACGACTTTCCTGCTCTTCAGTCAAAAGAG
TGCCATCAACCGCATGGTGATTGATGAACAACAGAGCCCCGACATCATCCTTCCCATCCACAGCCTTCGGAATGTCCGGGCCATTGACTA
TGACCCACTGGACAAGCAACTCTATTGGATTGACTCACGACAAAACATGATCCGAAAGGCACAAGAAGATGGCAGCCAGGGCTTTACTGT
GGTTGTGAGCTCAGTTCCGAGTCAGAACCTGGAAATACAACCCTATGACCTCAGCATTGATATTTACAGCCGCTACATCTACTGGACTTG
TGAGGCTACCAATGTCATTAATGTGACAAGATTAGATGGGAGATCAGTTGGAGTGGTGCTGAAAGGCGAGCAGGACAGACCTCGAGCCGT
TGTGGTAAACCCAGAGAAAGGGTATATGTATTTTACCAATCTTCAGGAAAGGTCTCCTAAAATTGAACGGGCTGCTTTGGATGGGACAGA
ACGGGAGGTCCTCTTTTTCAGTGGCTTAAGTAAACCAATTGCTTTAGCCCTTGATAGCAGGCTGGGCAAGCTCTTTTGGGCTGATTCAGA
TCTCCGGCGAATTGAAAGCAGTGATCTCTCAGGTGCTAACCGGATAGTATTAGAAGACTCCAATATCTTGCAGCCTGTGGGACTTACTGT
GTTTGAAAACTGGCTCTATTGGATTGATAAACAGCAGCAAATGATTGAAAAAATTGACATGACAGGTCGAGAGGGTAGAACCAAAGTCCA
AGCTCGAATTGCCCAGCTTAGTGACATTCATGCAGTAAAGGAGCTGAACCTTCAAGAATACAGACAGCACCCTTGTGCTCAGGATAATGG
TGGCTGTTCACATATTTGTCTTGTAAAGGGGGATGGTACTACAAGGTGTTCTTGCCCCATGCACCTGGTTCTACTTCAAGATGAGCTATC
ATGTGGAGAGTCCCAGTTCCAGTGTGCCAGTGGGCAGTGTATTGATGGTGCCCTCCGATGCAATGGAGATGCAAACTGCCAGGACAAATC
AGATGAGAAGAACTGTGAAGTGCTTTGTTTAATTGATCAGTTCCGCTGTGCCAATGGTCAGTGCATTGGAAAGCACAAGAAGTGTGATCA
TAATGTGGATTGCAGTGACAAGTCAGATGAACTGGATTGTTATCCGACTGAAGAACCAGCACCACAGGCCACCAATACAGTTGGTTCTGT
TATTGGCGTAATTGTCACCATTTTTGTGTCTGGAACTGTATACTTTATCTGCCAGAGGATGTTGTGTCCACGTATGAAGGGAGATGGGGA
AACTATGACTAATGACTATGTAGTTCATGGACCAGCTTCTGTGCCTCTTGGTTATGTGCCACACCCAAGTTCTTTGTCAGGATCTCTTCC
AGGAATGTCTCGAGGTAAATCAATGATCAGCTCCCTCAGTATCATGGGGGGAAGCAGTGGACCCCCCTATGACCGAGCCCATGTTACAGG
AGCATCATCAAGTAGTTCTTCAAGCACCAAAGGCACTTACTTCCCTGCAATTTTGAACCCTCCACCATCCCCAGCCACAGAGCGATCACA
TTACACTATGGAATTTGGATATTCTTCAAACAGTCCTTCCACTCATAGGTCATACAGCTACAGGCCATATAGCTACCGGCACTTTGCACC
CCCCACCACACCCTGCAGCACAGATGTTTGTGACAGTGACTATGCTCCTAGTCGGAGAATGACCTCAGTGGCAACAGCCAAGGGCTATAC
CAGTGACTTGAACTATGATTCAGAACCTGTGCCCCCACCTCCCACACCCCGAAGCCAATACTTGTCAGCAGAGGAGAACTATGAAAGCTG
CCCACCTTCTCCATACACAGAGAGGAGCTATTCTCATCACCTCTACCCACCGCCACCCTCTCCCTGTACAGACTCCTCCTGAGGAGGGGC

>49805_49805_2_LRP5-LRP6_LRP5_chr11_68115711_ENST00000294304_LRP6_chr12_12356334_ENST00000543091_length(amino acids)=1581AA_BP=472
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGFMYWTDWGEVPKIERAG
MDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG
LREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTP
DFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR
KILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVL
VEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIG
FELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYP
EGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLT
IDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ
SGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDK
QLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPE
KGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWL
YWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGESQ
FQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIV
TIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSS
SSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNY

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Top

Fusion Gene PPI Analysis for LRP5-LRP6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LRP5-LRP6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LRP5-LRP6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source