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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LRP6-PTPRO (FusionGDB2 ID:49835) |
Fusion Gene Summary for LRP6-PTPRO |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP6-PTPRO | Fusion gene ID: 49835 | Hgene | Tgene | Gene symbol | LRP6 | PTPRO | Gene ID | 4040 | 10076 |
| Gene name | LDL receptor related protein 6 | protein tyrosine phosphatase receptor type U | |
| Synonyms | ADCAD2|STHAG7 | FMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-J | |
| Cytomap | 12p13.2 | 1p35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 6LRP-6 | receptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronr | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000261349, ENST00000543091, ENST00000540415, | ENST00000543886, ENST00000544706, ENST00000281171, ENST00000348962, ENST00000442921, ENST00000445537, ENST00000542557, ENST00000544244, | |
| Fusion gene scores | * DoF score | 13 X 12 X 8=1248 | 10 X 11 X 6=660 |
| # samples | 18 | 11 | |
| ** MAII score | log2(18/1248*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/660*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LRP6 [Title/Abstract] AND PTPRO [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LRP6(12332744)-PTPRO(15733631), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LRP6 | GO:0014029 | neural crest formation | 11029007 |
| Hgene | LRP6 | GO:0014033 | neural crest cell differentiation | 11029007 |
| Hgene | LRP6 | GO:0016055 | Wnt signaling pathway | 11357136 |
| Hgene | LRP6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
| Hgene | LRP6 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 14739301 |
| Hgene | LRP6 | GO:0060070 | canonical Wnt signaling pathway | 11448771|11742004|12121999|14739301|15271658|15908424|16263759|16543246|17239604|19107203|20059949|20093106|20137080 |
| Hgene | LRP6 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 19107203 |
| Tgene | PTPRO | GO:0006470 | protein dephosphorylation | 12501215 |
| Tgene | PTPRO | GO:0008285 | negative regulation of cell proliferation | 16574648 |
| Tgene | PTPRO | GO:0030336 | negative regulation of cell migration | 12501215|16574648 |
| Tgene | PTPRO | GO:0034394 | protein localization to cell surface | 16574648 |
| Tgene | PTPRO | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 16574648 |
| Tgene | PTPRO | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin | 16574648 |
| Fusion gene breakpoints across LRP6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PTPRO (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PAAD | TCGA-F2-6879-01A | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| ChimerDB4 | PAAD | TCGA-F2-6879 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| ChimerDB4 | PAAD | TCGA-F2-6879 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
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Fusion Gene ORF analysis for LRP6-PTPRO |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000261349 | ENST00000543886 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| 5CDS-intron | ENST00000261349 | ENST00000543886 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| 5CDS-intron | ENST00000261349 | ENST00000544706 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| 5CDS-intron | ENST00000261349 | ENST00000544706 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| 5CDS-intron | ENST00000543091 | ENST00000543886 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| 5CDS-intron | ENST00000543091 | ENST00000543886 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| 5CDS-intron | ENST00000543091 | ENST00000544706 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| 5CDS-intron | ENST00000543091 | ENST00000544706 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000261349 | ENST00000281171 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000261349 | ENST00000281171 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000261349 | ENST00000348962 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000261349 | ENST00000348962 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000261349 | ENST00000442921 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000261349 | ENST00000442921 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000261349 | ENST00000445537 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000261349 | ENST00000445537 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000261349 | ENST00000542557 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000261349 | ENST00000542557 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000261349 | ENST00000544244 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000261349 | ENST00000544244 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000543091 | ENST00000281171 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000543091 | ENST00000281171 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000543091 | ENST00000348962 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000543091 | ENST00000348962 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000543091 | ENST00000442921 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000543091 | ENST00000442921 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000543091 | ENST00000445537 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000543091 | ENST00000445537 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000543091 | ENST00000542557 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000543091 | ENST00000542557 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| In-frame | ENST00000543091 | ENST00000544244 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| In-frame | ENST00000543091 | ENST00000544244 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-3CDS | ENST00000540415 | ENST00000281171 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-3CDS | ENST00000540415 | ENST00000281171 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-3CDS | ENST00000540415 | ENST00000348962 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-3CDS | ENST00000540415 | ENST00000348962 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-3CDS | ENST00000540415 | ENST00000442921 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-3CDS | ENST00000540415 | ENST00000442921 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-3CDS | ENST00000540415 | ENST00000445537 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-3CDS | ENST00000540415 | ENST00000445537 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-3CDS | ENST00000540415 | ENST00000542557 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-3CDS | ENST00000540415 | ENST00000542557 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-3CDS | ENST00000540415 | ENST00000544244 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-3CDS | ENST00000540415 | ENST00000544244 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-intron | ENST00000540415 | ENST00000543886 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-intron | ENST00000540415 | ENST00000543886 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| intron-intron | ENST00000540415 | ENST00000544706 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + |
| intron-intron | ENST00000540415 | ENST00000544706 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000261349 | LRP6 | chr12 | 12332744 | - | ENST00000281171 | PTPRO | chr12 | 15733631 | + | 3596 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332744 | - | ENST00000348962 | PTPRO | chr12 | 15733631 | + | 3596 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332744 | - | ENST00000542557 | PTPRO | chr12 | 15733631 | + | 3602 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332744 | - | ENST00000544244 | PTPRO | chr12 | 15733631 | + | 4634 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332744 | - | ENST00000445537 | PTPRO | chr12 | 15733631 | + | 4634 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332744 | - | ENST00000442921 | PTPRO | chr12 | 15733631 | + | 3602 | 1622 | 77 | 2275 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332744 | - | ENST00000281171 | PTPRO | chr12 | 15733631 | + | 3553 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332744 | - | ENST00000348962 | PTPRO | chr12 | 15733631 | + | 3553 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332744 | - | ENST00000542557 | PTPRO | chr12 | 15733631 | + | 3559 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332744 | - | ENST00000544244 | PTPRO | chr12 | 15733631 | + | 4591 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332744 | - | ENST00000445537 | PTPRO | chr12 | 15733631 | + | 4591 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332744 | - | ENST00000442921 | PTPRO | chr12 | 15733631 | + | 3559 | 1579 | 34 | 2232 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332743 | - | ENST00000281171 | PTPRO | chr12 | 15733630 | + | 3596 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332743 | - | ENST00000348962 | PTPRO | chr12 | 15733630 | + | 3596 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332743 | - | ENST00000542557 | PTPRO | chr12 | 15733630 | + | 3602 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332743 | - | ENST00000544244 | PTPRO | chr12 | 15733630 | + | 4634 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332743 | - | ENST00000445537 | PTPRO | chr12 | 15733630 | + | 4634 | 1622 | 77 | 2275 | 732 |
| ENST00000261349 | LRP6 | chr12 | 12332743 | - | ENST00000442921 | PTPRO | chr12 | 15733630 | + | 3602 | 1622 | 77 | 2275 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332743 | - | ENST00000281171 | PTPRO | chr12 | 15733630 | + | 3553 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332743 | - | ENST00000348962 | PTPRO | chr12 | 15733630 | + | 3553 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332743 | - | ENST00000542557 | PTPRO | chr12 | 15733630 | + | 3559 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332743 | - | ENST00000544244 | PTPRO | chr12 | 15733630 | + | 4591 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332743 | - | ENST00000445537 | PTPRO | chr12 | 15733630 | + | 4591 | 1579 | 34 | 2232 | 732 |
| ENST00000543091 | LRP6 | chr12 | 12332743 | - | ENST00000442921 | PTPRO | chr12 | 15733630 | + | 3559 | 1579 | 34 | 2232 | 732 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000261349 | ENST00000281171 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000939439 | 0.9990606 |
| ENST00000261349 | ENST00000348962 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000939439 | 0.9990606 |
| ENST00000261349 | ENST00000542557 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000926576 | 0.9990734 |
| ENST00000261349 | ENST00000544244 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.0009312 | 0.9990688 |
| ENST00000261349 | ENST00000445537 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.0009312 | 0.9990688 |
| ENST00000261349 | ENST00000442921 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000926576 | 0.9990734 |
| ENST00000543091 | ENST00000281171 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000914588 | 0.9990854 |
| ENST00000543091 | ENST00000348962 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000914588 | 0.9990854 |
| ENST00000543091 | ENST00000542557 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000903453 | 0.9990965 |
| ENST00000543091 | ENST00000544244 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000911403 | 0.99908864 |
| ENST00000543091 | ENST00000445537 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000911403 | 0.99908864 |
| ENST00000543091 | ENST00000442921 | LRP6 | chr12 | 12332744 | - | PTPRO | chr12 | 15733631 | + | 0.000903453 | 0.9990965 |
| ENST00000261349 | ENST00000281171 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000939439 | 0.9990606 |
| ENST00000261349 | ENST00000348962 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000939439 | 0.9990606 |
| ENST00000261349 | ENST00000542557 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000926576 | 0.9990734 |
| ENST00000261349 | ENST00000544244 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.0009312 | 0.9990688 |
| ENST00000261349 | ENST00000445537 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.0009312 | 0.9990688 |
| ENST00000261349 | ENST00000442921 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000926576 | 0.9990734 |
| ENST00000543091 | ENST00000281171 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000914588 | 0.9990854 |
| ENST00000543091 | ENST00000348962 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000914588 | 0.9990854 |
| ENST00000543091 | ENST00000542557 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000903453 | 0.9990965 |
| ENST00000543091 | ENST00000544244 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000911403 | 0.99908864 |
| ENST00000543091 | ENST00000445537 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000911403 | 0.99908864 |
| ENST00000543091 | ENST00000442921 | LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.000903453 | 0.9990965 |
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Fusion Genomic Features for LRP6-PTPRO |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.015988639 | 0.98401135 |
| LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.015988639 | 0.98401135 |
| LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.015988639 | 0.98401135 |
| LRP6 | chr12 | 12332743 | - | PTPRO | chr12 | 15733630 | + | 0.015988639 | 0.98401135 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LRP6-PTPRO |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12332744/chr12:15733631) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 282_324 | 515 | 1614.0 | Domain | Note=EGF-like 1 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 282_324 | 515 | 1614.0 | Domain | Note=EGF-like 1 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 20_275 | 515 | 1614.0 | Region | Note=Beta-propeller 1 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 20_275 | 515 | 1614.0 | Region | Note=Beta-propeller 1 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 107_149 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 150_193 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 194_236 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 237_276 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 372_414 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 415_457 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 7 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 458_501 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 8 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 63_106 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 1 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 107_149 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 2 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 150_193 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 3 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 194_236 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 4 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 237_276 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 5 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 372_414 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 6 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 415_457 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 7 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 458_501 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 8 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 63_106 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 1 |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 246_306 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 329_425 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 435_531 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 532_628 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 631_724 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 725_817 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 938_1195 | 188 | 723.6666666666666 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 246_306 | 188 | 406.0 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 329_425 | 188 | 406.0 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 435_531 | 188 | 406.0 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 532_628 | 188 | 406.0 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 631_724 | 188 | 406.0 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 725_817 | 188 | 406.0 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 938_1195 | 188 | 406.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 246_306 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 329_425 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 435_531 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 532_628 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 631_724 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 725_817 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 938_1195 | 160 | 695.6666666666666 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 246_306 | 160 | 378.0 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 329_425 | 160 | 378.0 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 435_531 | 160 | 378.0 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 532_628 | 160 | 378.0 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 631_724 | 160 | 378.0 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 725_817 | 160 | 378.0 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 938_1195 | 160 | 378.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 246_306 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 329_425 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 435_531 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 532_628 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 631_724 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 725_817 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 938_1195 | 188 | 723.6666666666666 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 246_306 | 188 | 406.0 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 329_425 | 188 | 406.0 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 435_531 | 188 | 406.0 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 532_628 | 188 | 406.0 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 631_724 | 188 | 406.0 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 725_817 | 188 | 406.0 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 938_1195 | 188 | 406.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 246_306 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 329_425 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 435_531 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 532_628 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 631_724 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 725_817 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 938_1195 | 160 | 695.6666666666666 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 246_306 | 160 | 378.0 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 329_425 | 160 | 378.0 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 435_531 | 160 | 378.0 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 532_628 | 160 | 378.0 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 631_724 | 160 | 378.0 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 725_817 | 160 | 378.0 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 938_1195 | 160 | 378.0 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 1136_1142 | 999 | 1516.6666666666667 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 1136_1142 | 971 | 1540.6666666666667 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 1136_1142 | 188 | 723.6666666666666 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 1136_1142 | 188 | 406.0 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 1136_1142 | 160 | 695.6666666666666 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 1136_1142 | 160 | 378.0 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 1136_1142 | 999 | 1516.6666666666667 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 1136_1142 | 971 | 1540.6666666666667 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 1136_1142 | 188 | 723.6666666666666 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 1136_1142 | 188 | 406.0 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 1136_1142 | 160 | 695.6666666666666 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 1136_1142 | 160 | 378.0 | Region | Substrate binding | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 844_1216 | 188 | 723.6666666666666 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 844_1216 | 188 | 406.0 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 844_1216 | 160 | 695.6666666666666 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 844_1216 | 160 | 378.0 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 844_1216 | 188 | 723.6666666666666 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 844_1216 | 188 | 406.0 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 844_1216 | 160 | 695.6666666666666 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 844_1216 | 160 | 378.0 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 823_843 | 188 | 723.6666666666666 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 823_843 | 188 | 406.0 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 823_843 | 160 | 695.6666666666666 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 823_843 | 160 | 378.0 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 823_843 | 188 | 723.6666666666666 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 823_843 | 188 | 406.0 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 823_843 | 160 | 695.6666666666666 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 823_843 | 160 | 378.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1203_1244 | 515 | 1614.0 | Domain | Note=EGF-like 4 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1248_1286 | 515 | 1614.0 | Domain | LDL-receptor class A 1 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1287_1323 | 515 | 1614.0 | Domain | LDL-receptor class A 2 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1325_1361 | 515 | 1614.0 | Domain | LDL-receptor class A 3 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 588_628 | 515 | 1614.0 | Domain | Note=EGF-like 2 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 889_930 | 515 | 1614.0 | Domain | Note=EGF-like 3 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1203_1244 | 515 | 1614.0 | Domain | Note=EGF-like 4 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1248_1286 | 515 | 1614.0 | Domain | LDL-receptor class A 1 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1287_1323 | 515 | 1614.0 | Domain | LDL-receptor class A 2 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1325_1361 | 515 | 1614.0 | Domain | LDL-receptor class A 3 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 588_628 | 515 | 1614.0 | Domain | Note=EGF-like 2 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 889_930 | 515 | 1614.0 | Domain | Note=EGF-like 3 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1487_1493 | 515 | 1614.0 | Motif | Note=PPPSP motif A |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1527_1534 | 515 | 1614.0 | Motif | Note=PPPSP motif B |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1568_1575 | 515 | 1614.0 | Motif | Note=PPPSP motif C |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1588_1593 | 515 | 1614.0 | Motif | Note=PPPSP motif D |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1603_1610 | 515 | 1614.0 | Motif | Note=PPPSP motif E |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1487_1493 | 515 | 1614.0 | Motif | Note=PPPSP motif A |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1527_1534 | 515 | 1614.0 | Motif | Note=PPPSP motif B |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1568_1575 | 515 | 1614.0 | Motif | Note=PPPSP motif C |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1588_1593 | 515 | 1614.0 | Motif | Note=PPPSP motif D |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1603_1610 | 515 | 1614.0 | Motif | Note=PPPSP motif E |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 328_589 | 515 | 1614.0 | Region | Note=Beta-propeller 2 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 631_890 | 515 | 1614.0 | Region | Note=Beta-propeller 3 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 933_1202 | 515 | 1614.0 | Region | Note=Beta-propeller 4 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 328_589 | 515 | 1614.0 | Region | Note=Beta-propeller 2 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 631_890 | 515 | 1614.0 | Region | Note=Beta-propeller 3 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 933_1202 | 515 | 1614.0 | Region | Note=Beta-propeller 4 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1026_1068 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 17 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1069_1113 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 18 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1114_1156 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 19 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1157_1198 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 20 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 502_542 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 9 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 543_584 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 10 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 674_716 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 11 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 717_759 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 12 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 760_802 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 13 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 803_842 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 14 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 843_885 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 15 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 977_1025 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 16 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1026_1068 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 17 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1069_1113 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 18 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1114_1156 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 19 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1157_1198 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 20 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 502_542 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 9 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 543_584 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 10 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 674_716 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 11 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 717_759 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 12 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 760_802 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 13 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 803_842 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 14 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 843_885 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 15 |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 977_1025 | 515 | 1614.0 | Repeat | Note=LDL-receptor class B 16 |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1394_1613 | 515 | 1614.0 | Topological domain | Cytoplasmic |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 20_1370 | 515 | 1614.0 | Topological domain | Extracellular |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1394_1613 | 515 | 1614.0 | Topological domain | Cytoplasmic |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 20_1370 | 515 | 1614.0 | Topological domain | Extracellular |
| Hgene | LRP6 | chr12:12332743 | chr12:15733630 | ENST00000261349 | - | 7 | 23 | 1371_1393 | 515 | 1614.0 | Transmembrane | Helical |
| Hgene | LRP6 | chr12:12332744 | chr12:15733631 | ENST00000261349 | - | 7 | 23 | 1371_1393 | 515 | 1614.0 | Transmembrane | Helical |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 142_211 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 246_306 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 329_425 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 435_531 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 50_124 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 532_628 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 631_724 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 725_817 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 938_1195 | 999 | 1516.6666666666667 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 142_211 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 246_306 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 329_425 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 435_531 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 50_124 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 532_628 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 631_724 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 725_817 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 938_1195 | 971 | 1540.6666666666667 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 142_211 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 50_124 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 142_211 | 188 | 406.0 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 50_124 | 188 | 406.0 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 142_211 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 50_124 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 142_211 | 160 | 378.0 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 50_124 | 160 | 378.0 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 142_211 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 246_306 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 329_425 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 435_531 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 50_124 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 532_628 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 631_724 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 725_817 | 999 | 1516.6666666666667 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 938_1195 | 999 | 1516.6666666666667 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 142_211 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 246_306 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 3 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 329_425 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 4 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 435_531 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 5 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 50_124 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 532_628 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 6 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 631_724 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 7 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 725_817 | 971 | 1540.6666666666667 | Domain | Fibronectin type-III 8 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 938_1195 | 971 | 1540.6666666666667 | Domain | Tyrosine-protein phosphatase | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 142_211 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 50_124 | 188 | 723.6666666666666 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 142_211 | 188 | 406.0 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 50_124 | 188 | 406.0 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 142_211 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 50_124 | 160 | 695.6666666666666 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 142_211 | 160 | 378.0 | Domain | Fibronectin type-III 2 | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 50_124 | 160 | 378.0 | Domain | Fibronectin type-III 1 | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 30_822 | 999 | 1516.6666666666667 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 844_1216 | 999 | 1516.6666666666667 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 30_822 | 971 | 1540.6666666666667 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 844_1216 | 971 | 1540.6666666666667 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000442921 | 8 | 15 | 30_822 | 188 | 723.6666666666666 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000445537 | 8 | 14 | 30_822 | 188 | 406.0 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000542557 | 7 | 14 | 30_822 | 160 | 695.6666666666666 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000544244 | 7 | 13 | 30_822 | 160 | 378.0 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 30_822 | 999 | 1516.6666666666667 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 844_1216 | 999 | 1516.6666666666667 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 30_822 | 971 | 1540.6666666666667 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 844_1216 | 971 | 1540.6666666666667 | Topological domain | Cytoplasmic | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000442921 | 8 | 15 | 30_822 | 188 | 723.6666666666666 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000445537 | 8 | 14 | 30_822 | 188 | 406.0 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000542557 | 7 | 14 | 30_822 | 160 | 695.6666666666666 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000544244 | 7 | 13 | 30_822 | 160 | 378.0 | Topological domain | Extracellular | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000281171 | 20 | 27 | 823_843 | 999 | 1516.6666666666667 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332743 | chr12:15733630 | ENST00000348962 | 19 | 26 | 823_843 | 971 | 1540.6666666666667 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000281171 | 20 | 27 | 823_843 | 999 | 1516.6666666666667 | Transmembrane | Helical | |
| Tgene | PTPRO | chr12:12332744 | chr12:15733631 | ENST00000348962 | 19 | 26 | 823_843 | 971 | 1540.6666666666667 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for LRP6-PTPRO |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >49835_49835_1_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000281171_length(transcript)=3596nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT >49835_49835_1_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000281171_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_2_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000348962_length(transcript)=3596nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT >49835_49835_2_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000348962_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_3_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000442921_length(transcript)=3602nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT GATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGT >49835_49835_3_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000442921_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_4_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000445537_length(transcript)=4634nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGTAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAG AGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTTGTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCT CACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCTTTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTT CTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAACCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATAC TACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATTGATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATT GGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCAGGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCC CTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACGTCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAG TAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGTAAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAAT GACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCATGAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCAC TGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAGCAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTG GGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACACAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGAC TGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGTGACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGG ACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATA TGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCG GGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTT TAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATC AGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATT ATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGA TCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTT CAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCT TTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCT GTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGC TGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTA CTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTT AACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGA CATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAG >49835_49835_4_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000445537_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_5_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000542557_length(transcript)=3602nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT GATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGT >49835_49835_5_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000542557_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_6_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000544244_length(transcript)=4634nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGTAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAG AGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTTGTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCT CACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCTTTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTT CTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAACCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATAC TACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATTGATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATT GGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCAGGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCC CTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACGTCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAG TAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGTAAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAAT GACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCATGAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCAC TGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAGCAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTG GGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACACAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGAC TGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGTGACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGG ACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATA TGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCG GGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTT TAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATC AGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATT ATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGA TCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTT CAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCT TTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCT GTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGC TGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTA CTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTT AACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGA CATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAG >49835_49835_6_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000544244_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_7_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000281171_length(transcript)=3553nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_7_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000281171_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_8_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000348962_length(transcript)=3553nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_8_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000348962_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_9_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000442921_length(transcript)=3559nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_9_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000442921_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_10_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000445537_length(transcript)=4591nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG TAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAGAGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTT GTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCTCACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCT TTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTTCTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAA CCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATACTACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATT GATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATTGGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCA GGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCCCTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACG TCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAGTAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGT AAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAATGACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCAT GAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCACTGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAG CAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTGGGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACA CAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGACTGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGT GACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAG TGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGA CTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGG TCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAG TGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCA TAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTA CTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCC ACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCT TGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCAC ATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTG TTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTAT GAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACA GAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATA ATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTG ATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTG >49835_49835_10_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000445537_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_11_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000542557_length(transcript)=3559nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_11_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000542557_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_12_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000544244_length(transcript)=4591nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG TAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAGAGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTT GTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCTCACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCT TTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTTCTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAA CCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATACTACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATT GATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATTGGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCA GGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCCCTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACG TCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAGTAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGT AAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAATGACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCAT GAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCACTGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAG CAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTGGGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACA CAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGACTGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGT GACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAG TGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGA CTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGG TCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAG TGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCA TAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTA CTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCC ACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCT TGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCAC ATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTG TTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTAT GAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACA GAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATA ATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTG ATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTG >49835_49835_12_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000544244_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_13_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000281171_length(transcript)=3596nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT >49835_49835_13_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000281171_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_14_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000348962_length(transcript)=3596nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT >49835_49835_14_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000348962_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_15_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000442921_length(transcript)=3602nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT GATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGT >49835_49835_15_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000442921_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_16_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000445537_length(transcript)=4634nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGTAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAG AGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTTGTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCT CACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCTTTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTT CTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAACCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATAC TACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATTGATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATT GGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCAGGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCC CTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACGTCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAG TAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGTAAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAAT GACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCATGAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCAC TGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAGCAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTG GGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACACAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGAC TGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGTGACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGG ACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATA TGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCG GGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTT TAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATC AGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATT ATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGA TCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTT CAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCT TTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCT GTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGC TGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTA CTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTT AACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGA CATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAG >49835_49835_16_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000445537_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_17_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000542557_length(transcript)=3602nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTA GTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAG ACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAG GTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAA GTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCC ATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCT ACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACC CACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTC TTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCA CATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCT GTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTA TGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGAC AGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTAT AATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCT GATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGT >49835_49835_17_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000542557_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_18_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000544244_length(transcript)=4634nt_BP=1622nt GCGGCCGCCCCGGCTCCTCGCCTCCCCCACTTCTGGCCACCCCTCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCC TGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGCGGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTG ATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGGCTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGA TATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGAATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTAT TGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATTGTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAG ATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCAACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGA CAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGATGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAA ATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGCAGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAA ATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGCCTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACAC ACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCGTGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCA GCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGACAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTT TTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAATGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTC GAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTTTACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCA TAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGATGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTC AGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGCTGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTG ATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGATCTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATC CCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCCGAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGG TTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTATGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTG AGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAA AGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAG CCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGA TGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTAC ACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCC TGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGG TACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCA TATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAGTAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAG AGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTTGTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCT CACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCTTTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTT CTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAACCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATAC TACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATTGATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATT GGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCAGGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCC CTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACGTCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAG TAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGTAAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAAT GACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCATGAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCAC TGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAGCAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTG GGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACACAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGAC TGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGTGACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGG ACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATA TGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCG GGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTT TAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATC AGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATT ATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGA TCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTT CAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCT TTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCT GTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGC TGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTA CTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTT AACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGA CATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAG >49835_49835_18_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000544244_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_19_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000281171_length(transcript)=3553nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_19_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000281171_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_20_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000348962_length(transcript)=3553nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_20_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000348962_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_21_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000442921_length(transcript)=3559nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_21_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000442921_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_22_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000445537_length(transcript)=4591nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG TAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAGAGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTT GTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCTCACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCT TTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTTCTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAA CCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATACTACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATT GATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATTGGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCA GGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCCCTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACG TCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAGTAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGT AAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAATGACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCAT GAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCACTGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAG CAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTGGGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACA CAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGACTGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGT GACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAG TGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGA CTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGG TCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAG TGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCA TAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTA CTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCC ACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCT TGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCAC ATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTG TTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTAT GAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACA GAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATA ATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTG ATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTG >49835_49835_22_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000445537_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_23_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000542557_length(transcript)=3559nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG AGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAGTGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTG TAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGACTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCA CTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGGTCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAA GAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAGTGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTC TTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCATAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACC TCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTACTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTA CCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCCACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTC AGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCTTGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTG GCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCACATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTG TTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTGTTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATA TAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTATGAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTT GACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACAGAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTC ATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATAATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAA AATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTGATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACT >49835_49835_23_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000542557_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- >49835_49835_24_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000544244_length(transcript)=4591nt_BP=1579nt TCGCCGGTGAGAGAAGAGAACGCGAGAAGGGAAGATGGGGGCCGTCCTGAGGAGCCTCCTGGCCTGCAGCTTCTGTGTGCTCCTGAGAGC GGCCCCTTTGTTGCTTTATGCAAACAGACGGGACTTGCGATTGGTTGATGCTACAAATGGCAAAGAGAATGCTACGATTGTAGTTGGAGG CTTGGAGGATGCAGCTGCGGTGGACTTTGTGTTTAGTCATGGCTTGATATACTGGAGTGATGTCAGCGAAGAAGCCATTAAACGAACAGA ATTTAACAAAACTGAGAGTGTGCAGAATGTTGTTGTTTCTGGATTATTGTCCCCCGATGGGCTGGCATGTGATTGGCTTGGAGAAAAATT GTACTGGACAGATTCTGAAACTAATCGGATTGAAGTTTCTAATTTAGATGGATCTTTACGAAAAGTTTTATTTTGGCAAGAGTTGGATCA ACCCAGAGCTATTGCCTTAGATCCTTCAAGTGGGTTCATGTACTGGACAGACTGGGGAGAAGTGCCAAAGATAGAACGTGCTGGAATGGA TGGTTCAAGTCGCTTCATTATAATAAACAGTGAAATTTACTGGCCAAATGGACTGACTTTGGATTATGAAGAACAAAAGCTTTATTGGGC AGATGCAAAACTTAATTTCATCCACAAATCAAATCTGGATGGAACAAATCGGCAGGCAGTGGTTAAAGGTTCCCTTCCACATCCTTTTGC CTTGACGTTATTTGAGGACATATTGTACTGGACTGACTGGAGCACACACTCCATTTTGGCTTGCAACAAGTATACTGGTGAGGGTCTGCG TGAAATCCATTCTGACATCTTCTCTCCCATGGATATACATGCCTTCAGCCAACAGAGGCAGCCAAATGCCACAAATCCATGTGGAATTGA CAATGGGGGTTGTTCCCATTTGTGTTTGATGTCTCCAGTCAAGCCTTTTTATCAGTGTGCTTGCCCCACTGGGGTCAAACTCCTGGAGAA TGGAAAAACCTGCAAAGATGGTGCCACAGAATTATTGCTTTTAGCTCGAAGGACAGACTTGAGACGCATTTCTTTGGATACACCAGATTT TACAGACATTGTTCTGCAGTTAGAAGACATCCGTCATGCCATTGCCATAGATTACGATCCTGTGGAAGGCTACATCTACTGGACTGATGA TGAAGTGAGGGCCATACGCCGTTCATTTATAGATGGATCTGGCAGTCAGTTTGTGGTCACTGCTCAAATTGCCCATCCTGATGGTATTGC TGTGGACTGGGTTGCACGAAATCTTTATTGGACAGACACTGGCACTGATCGAATAGAAGTGACAAGGCTCAATGGGACCATGAGGAAGAT CTTGATTTCAGAGGACTTAGAGGAACCCCGGGCTATTGTGTTAGATCCCATGGTTGGGTACATGTATTGGACTGACTGGGGAGAAATTCC GAAAATTGAGCGAGCAGCTCTGGATGGTTCTGACCGTGTAGTATTGGTTAACACTTCTCTTGGTTGGCCAAATGGTTTAGCCTTGGATTA TGATGAAGGCAAAATATACTGGGGAGATGCCAAAACAGACAAGATTGAGGGATACAACTCACCCCAGGAGTATATTGCCACCCAGGGGCC ACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAAAAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAG GAGGGTGAAATGTGACCATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATTTCAGAGGAAGAGCA GGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAGATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCA TGGTGTGCCCACAGCAAATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGCAAAGGTCCCATGAT CATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCCCTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGA CATCTTAGGGCTGGTGTCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATCCATCAGTGTGTGCA ACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTCATATACGAGAATGTTAGCAAGTCCTAGTTCAGAATCCGGAGCAG TAAGTGGAGAAGAGCTCTCCACGAGTGCTCAGTCTTAGAACTATTAGAGGGGGATGTGATGGATGGGACAAAAGACAGCAGTAGCCATTT GTATTGACTCTGACTTCACATGAGTATTTCTTCCCAGCTCCTGGCCTCACATGGGTGGTCACAGGGAGAAACAAGTACTGTAGCAGATCT TTGAGTTTCAATGCACCTTGGTTGGTGTTGGCAACAAACAGGAGCTTCTGCACATCATGATGACTTTACCTCCATTCCCTCTACCCAGAA CCCTAAATTATTCTGTTATTGGATCTGTGCCTGTAATATCAGGATACTACCATCCAAATCTATCTAGATATCTTGTGCAAATATTTTATT GATTACAAGGGCTGTATACGGGGTTACAAAAAGACATGAGCTGGATTGGACACTCCTAAAACCAAAAACAACAGTGACAATAGAGTCTCA GGATAGCAGAGTCTGAAAATACCTTGGTCTCCCCCATTATGTGAGCCCTTACTTGAGAGCTTCATGAAGACACTTGTAACATATTCAACG TCCTGTACTCCAGTTTTGACTACGAGATCAGATTTTGGAGGTGTAAGTAAACTTGGCTGAGGTAACAGTAATCTGCCCATTTAGTTCAGT AAACAGACTGTAGAGTGTCTGACTATACTGGGGGAAGAGGAGCCAATGACAGGGTAGGGAGATGACAGTGGTGCATGATGGGAGAATCAT GAAAGTCTGGGAAGCATATGGACCAGTGGGAAGGATAGGATTAGCACTGCACCTCTACATCCATCAAGAGAGACAGAGCGCACAATGGAG CAGGAAGGATAAAAAATAAAGAAAGACAGAGAGAAACAAATTTGCTGGGAGAGGGAAAGACATTCAGACCCACAGAAAGGAGGCAGCACA CAGAGAAAGATGCACAGATCAACCCACATCTGCATGGGTTGTGAGACTGAGCATAGTGAGAGCAGTGGTGGAGCAATAGAAGATTGCTGT GACACCAGGCTGCTTACTGTCTTTCTTTGTCTCATTCACAGGAGAGGACATGATGTGCGCCCATCCTCCCTTGCTTCCAGATTGTTTTAG TGGGCCCTGATGGTCATTTTTCTAAACAGAGGCCCTGCTTTGTAATATGTGGCCAAGGAGATAATTTATCTCACAGAAGCACCGGGAAGA CTTAGCCTTAAAGAGCCTACAGTGTCCTTTTGGACTCTTTCACTTCGGGACATTTAATAATGGACCAAATTCAACAGAACACCAGGAAGG TCAAGACGCTCTCCAAAGGGCAGGAAGTACAGCACTTCCGAAGAGTTTAGTTGGCCCTTTGCTGGTTGGGCTGAGTTTTTTATTTTTAAG TGTTTGTTTTTCAGTGCAATAATTTTTGTGTGTGTGTGATTCTTATCAGAAAGTTGAATTGTTTTCTGCCTACACCGTTCATCAGCCCCA TAACCCAGGAAGGAACAGGCATTGTTAGCATCAGATTATACCTCATTATTAAAAGGAGGCATGGCCACACATGAAGAAATGGTCATTCTA CTTCAAAGAAATTGAGCCAGCACTATCTGTACTCCAACATTACCGGATCTGGATTGGGGAGGTTGGTCAGGGAAGAGAGGGGTTCTACCC ACAGATCAACTGTGTAATCTTTTACTATTCAAGCTATAATTCAGCTTCAAAGTAGAGTAGAAAAAAAATTGTCTTAACTGTTCTAGTTCT TGATGGTTTTCTTCCTTATTAACAGTTGGTGTTTCTTCCTTGGCCCTTTTGGACTAATGTTACTGTCCAAGTTCTTTCTCAAGAAACCAC ATCTGGTTCAGAAGAGTGTCAAGTTGGACTCTTTGAACTCTGTTGCTGTCTGAGCAATCGTGGTGCCTAGACTTTGCATTCCTTGTTCTG TTGACCTGCATACATGTGAGAGCTATTTCTTTAAGAACTATATAGGCTGTGAAAACGCACTTTCTTTCCCCCAAAGAGCTGGGAATTTAT GAAGTTATGGCAATGAACTGCAGCATGCTGGGACAATTATTTGACTACTTTTTTTTGTAATATTGTCAAATGTCTCTATGGATTCTGACA GAGATTTCTTTTTGTTTTGTTATTCTTTTGGTTGTCAGTTTCATTTTAACGAGTGTAACTAGTAACATTTTATTCTTTGGATTTTGTATA ATTACAGTACATGATTGTGTATTGTGACATGAATGCTGTCAAAATGACATTGATGGCATTGTGAAGCCTGTTACTTTGTGTCACTTCCTG ATAAATAAGAGGTGATGACATGGATATACAACAGAAAACACTTTGAGTTGAAAGTAAACACAAGCTGGCTGCTTCCCTGTGGCAACTGTG >49835_49835_24_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000544244_length(amino acids)=732AA_BP=515 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for LRP6-PTPRO |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LRP6-PTPRO |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LRP6-PTPRO |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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