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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LRRC19-SNAPC3 (FusionGDB2 ID:49877)

Fusion Gene Summary for LRRC19-SNAPC3

Fusion gene summary

Fusion gene information	Fusion gene name: LRRC19-SNAPC3
	Fusion gene ID: 49877
		Hgene	Tgene
	Gene symbol	LRRC19	SNAPC3
	Gene ID	64922	6619
	Gene name	leucine rich repeat containing 19	small nuclear RNA activating complex polypeptide 3
	Synonyms	-	PTFbeta\|SNAP50
	Cytomap	9p21.2	9p22.3
	Type of gene	protein-coding	protein-coding
	Description	leucine-rich repeat-containing protein 19	snRNA-activating protein complex subunit 3PSE-binding factor subunit betaPTF subunit betaSNAPc 50 kDa subunitSNAPc subunit 3proximal sequence element-binding transcription factor subunit betasmall nuclear RNA activating complex, polypeptide 3, 50kD
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000380055, ENST00000482770,	ENST00000380799, ENST00000461041, ENST00000380821,
Fusion gene scores	* DoF score	1 X 2 X 1=2	3 X 4 X 2=24
	# samples	2	4
	** MAII score	log2(2/2*10)=3.32192809488736	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: LRRC19 [Title/Abstract] AND SNAPC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LRRC19(26996309)-SNAPC3(15453039), # samples:1 LRRC19(26996308)-SNAPC3(15453038), # samples:1 SNAPC3(15451400)-LRRC19(26999701), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LRRC19	GO:1901224	positive regulation of NIK/NF-kappaB signaling	19679103

Fusion gene breakpoints across LRRC19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SNAPC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-22-5489-01A	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+
ChimerDB4	LUSC	TCGA-22-5489	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+

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Fusion Gene ORF analysis for LRRC19-SNAPC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000380055	ENST00000380799	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+
5CDS-intron	ENST00000380055	ENST00000380799	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+
5CDS-intron	ENST00000380055	ENST00000461041	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+
5CDS-intron	ENST00000380055	ENST00000461041	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+
5UTR-3CDS	ENST00000482770	ENST00000380821	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+
5UTR-3CDS	ENST00000482770	ENST00000380821	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+
5UTR-intron	ENST00000482770	ENST00000380799	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+
5UTR-intron	ENST00000482770	ENST00000380799	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+
5UTR-intron	ENST00000482770	ENST00000461041	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+
5UTR-intron	ENST00000482770	ENST00000461041	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+
In-frame	ENST00000380055	ENST00000380821	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+
In-frame	ENST00000380055	ENST00000380821	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000380055

LRRC19

chr9

26996309

ENST00000380821

SNAPC3

chr9

15453039

5584

895

111

1058

315

ENST00000380055

LRRC19

chr9

26996308

ENST00000380821

SNAPC3

chr9

15453038

5584

895

111

1058

315

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000380055	ENST00000380821	LRRC19	chr9	26996309	-	SNAPC3	chr9	15453039	+	0.002157904	0.9978421
ENST00000380055	ENST00000380821	LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+	0.002157904	0.9978421

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Fusion Genomic Features for LRRC19-SNAPC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+	0.014304648	0.9856954
LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+	0.014304648	0.9856954
LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+	0.014304648	0.9856954
LRRC19	chr9	26996308	-	SNAPC3	chr9	15453038	+	0.014304648	0.9856954

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRC19-SNAPC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:26996309/chr9:15453039)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

176_227

261

371.0

Domain

LRRCT

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

176_227

261

371.0

Domain

LRRCT

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

120_143

261

371.0

Repeat

LRR 4

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

145_168

261

371.0

Repeat

LRR 5

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

46_71

261

371.0

Repeat

LRR 1

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

72_95

261

371.0

Repeat

LRR 2

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

96_119

261

371.0

Repeat

LRR 3

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

120_143

261

371.0

Repeat

LRR 4

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

145_168

261

371.0

Repeat

LRR 5

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

46_71

261

371.0

Repeat

LRR 1

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

72_95

261

371.0

Repeat

LRR 2

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

96_119

261

371.0

Repeat

LRR 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

25_270

261

371.0

Topological domain

Extracellular

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

292_370

261

371.0

Topological domain

Cytoplasmic

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

25_270

261

371.0

Topological domain

Extracellular

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

292_370

261

371.0

Topological domain

Cytoplasmic

Hgene

LRRC19

chr9:26996308

chr9:15453038

ENST00000380055

271_291

261

371.0

Transmembrane

Helical

Hgene

LRRC19

chr9:26996309

chr9:15453039

ENST00000380055

271_291

261

371.0

Transmembrane

Helical

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Fusion Gene Sequence for LRRC19-SNAPC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>49877_49877_1_LRRC19-SNAPC3_LRRC19_chr9_26996308_ENST00000380055_SNAPC3_chr9_15453038_ENST00000380821_length(transcript)=5584nt_BP=895nt
AAAACAAAGTGAAATGTAATCATACGATGTACTTTTTTTAATGCCGTTGAAACAGAGTTAATTTCCTTTAGCACACAAGTCTTAGAGACA
AAAGAAAAAAAGGTCTGCAACATGAAAGTCACAGGCATCACAATCCTCTTTTGGCCCCTCTCCATGATATTATTATCAGACAAAATCCAG
TCTTCTAAAAGAGAAGTCCAATGTAATTTTACTGAAAAAAATTATACCTTGATTCCAGCAGATATCAAGAAAGATGTTACTATACTTGAT
CTCAGTTATAACCAAATTACTCTTAATGGTACAGACACAAGAGTTCTACAGACATACTTTTTACTCACAGAGCTCTATTTGATTGAGAAC
AAGGTTACTATCTTACATAATAACGGTTTTGGTAACCTCTCCAGTCTAGAAATTTTAAATATCTGTAGAAACTCCATCTATGTAATTCAA
CAGGGTGCATTTTTAGGCTTAAATAAACTAAAACAGTTATATCTCTGCCAAAACAAAATAGAACAACTGAATGCTGATGTATTTGTGCCT
CTAAGAAGCCTAAAACTTCTGAATCTGCAAGGCAATTTGATTAGCTATTTGGATGTACCACCACTATTTCATCTGGAATTAATAACTTTA
TATGGAAACCTATGGAACTGCTCTTGCAGTCTATTTAATTTGCAGAACTGGTTGAACACATCAAATGTGACATTAGAAAATGAGAACATC
ACCATGTGTAGCTACCCCAACAGCCTGCAGAGCTACAATATCAAAACAGTACCTCATAAGGCTGAATGCCACTCAAAATTTCCTTCATCA
GTAACTGAAGATCTTTATATTCATTTTCAGCCCATCAGCAATTCAATATTTAATAGCTCTTCGAACAACTTAACAAGAAATTCAGAACTA
TCATTGAGTGGTCAGAGTCCCATGATAGAGGCTATGGAAAGTTTCAGACTGCTAGAATGGAAGATTTCACCTTCAATGACTTGTGTATTA
AACTGGGTTTTCCTTACTTATACTGTCATCAGGGAGACTGTGAACATGTCATTGTCATTACTGACATAAGGCTTGTGCATCATGATGACT
GCTTGGATAGGACATTGTATCCCCTCCTTATCAAGAAGCATTGGCTATGGACCAGAAAATGTTTTGTTTGTAAAATGTATACAGCCAGAT
GGGTGACGAACAATGACAGTTTTGCACCAGAGGACCCATGCTTCTTTTGTGATGTTTGCTTCCGAATGCTGCACTATGATTCAGAAGGCA
ACAAACTGGGGGAATTCCTTGCTTATCCTTATGTTGATCCTGGAACCTTTAATTAAGAATAGCTACACTCACAAAAATACCCCCTCATGA
AATAACTGTTCTCTTGGATGGTTACCTTATTTCTAAGAAACGCCACTGAGGAACAGGATCCACTTTGAACAGTCCGCTAAAGCTATCAAA
AAAAAGTCCAAATGACAGATTTTCTTATAATGATAGTATTTAAATGTTTATAACATAGTTTAATTTTATATTTATTCCAGATAGTATTTA
ATTTAGTGCTTTTTACCCATTTTGAGTTGAGTTGTAGTACTTTATATATTCTGACTTTAAATCCTTTGTCAGACACACATATTCTTTCTC
CCAATCCATGCCTTCCCTATTCATTCTCTGTCCAGAGTTTTTTGCTAAAGATAGAATTATTAATGATACATCAAGTAGTGGAAGTGTTTT
GAAAATTCTTTGAAGAATGTGAGAGCTACACCTTCTACCATGAGGCTTCCAAGGTAAAGATCCTTCAAATAACTGTAATGGAAACTAGGG
AGAATGAATTATTTACAAATAAGACAAAATTAATAGCTTTGGGATTATTTATTTTTTGAGACAAAATCTCGCTCTTGTTGCCCAGGCTGG
AATACAGTGGCGCAATCTCAGCTCACTGCAGCCTCCGCCTCCCGGATTCAAGTGATTCTCCTGCCACAGCCTCCTGAGTAGCTGGGATTG
CAGGCACCTGGCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTAA
CCTCAGGCGATCCACCCGCCTAAGCCTCCCAAAATTTTGGGATCACAGGCGTGAGCCACCGCGCCCGGCTGCTTTGGGGGAATTTAATCT
TAGTGTGCTGTTTAGTAATGTTAGGTTTTGTTTTGGAGGAAACTAGGCATACAAGACATGTTAATAAGACTATGTGAATAATGAATTTAA
AAAGATCTTGAGTATATACTCATAACTCCAGAAATAACATTAACTTGAAGCTTTATTTCTTGACAAAAGCTTTATGAATGTTATGAGTTT
AAAATATGTCAATTTAATACTATGATTTAAAAAACAATAGCAGATTTCGTATGACTGTGGGGACATGGAAAAATCAAGATCCTATTGATT
GCTAGCTCTGGCTCACTTATTCTCCGGTAATGATACTATTGGATATATACCAAAATTATATAAGCAAAAAGAAAAAAAATAAGTTTTCCT
GGCCCAGGTCTTCCATTCTTCTGGTCCCCTTACTATAGTAATTCTAGTTACTCTCATCTTATTCTGAGGAAAAAAAAAAAAACCAAAACT
TTTTAAACTTATTTTTTGACATAGGGTCTTACTGTGTCACCCAGGCTGGAGTACAGTGGCGTGATCTTGGCTCACTGGAGCCCTGACCTC
CCTAGGCTCAGGTGATCCTCCCACCTCAGCCTACCGAGTAGCTGAGACATGGTGGCACAGGCCACCATGGCGGGCTAATTTTTTTATTTC
TTGTAGATACAGGGTTTCACTATGTTGCGCAGAATAGTCTCGAACTCCTGACCTCAAGTGATCCATCCGCCTTGGCCTCCCAGAGTGCTG
CGATTACAGGCATGAACCACAGCGCCCAGCAAAATAAACTTTCTTTATTTTCAGGTCTAGACCATCAGATAGATTTATTCAAATATTTTC
TGGGAACCTTTATGGGTAGAACATTTAATACTGTTTAGAAGACTTTTAGGAATACTATAGATTTCAAATGCATCATTTAAAATAAATAAA
TTCCACTTTCTCTCTCCTAGGTTGTATTTAAATTTGACTGAATATCTGGATGGCTAAGAACAGACATTTATCTTACACATGGAAAACTGA
CGAAACCTATAAGCCTATGTGTTTGACAGTGAAGTATGTTTTATGGACTTAAATGCCACAAACAGTTAAGTCCATTGGCTTGGAGATGAC
AAGCACGAGTTTCTGGTATGTCTAGTGTTCTCATTCACTGATTCAGTCAGTACACAGATAATCAGTATAGAGAACTTAAGAGGCTGGCTT
ATGTTATACCTAAATTTTTACTTTCTTGTATACAACAATGCTAAAATTGAGCAGATTGATAACTGCCAGCAAACCATAGATTTAAGATAA
ATGAATGATTTACCCAACCCTAAAATTCCATGGGTAAAAATTTTGATTCCTTTATTTTCAATACTGCGTTCCTTATAGGTCTTACATGCA
TATGCAAGGATATTTTATCTTATTCATTCATTTCATACTCTCAAAACACCAAACTTCAAAAAGTTAATTATTGTCATAATGCATTATTCC
ATGTGTGGTGTCAATACATTTTAGCGGACAAAGAAGAAACATGCCAGTTAAAACATTTCTGCTACTGGGATTCTTTATTAATTATTTGAG
AATGTTATTTTGCTAGTTCTTAAGGTTAAGTTTTTCATCAAAGACTCAGGTACCTATTATTGTTCCCTGGTGAAACTGAGGAGAAAAGTT
AATCAACCAGGTTACTCCCACAGTTTGCCCGTGTGTTATGTATCAGTTATACAGGTATCCCACCAAGTTCAAGTCAAAAGAAATTCCTAA
CTTTGTATATTTCTGGAGCTATAAAACCCCTGATTTAAGACAGCTTTTCTCTTTTTTCGAGGCAGCTTTTCTTTATGCTTATTTCAATCA
AATGTAACACGCCTGTCAAATTACATGTAACACATTAGCTAATGAAGATAGGCAACTGAAAATGTTGTCATGAACATGTCAACCTGCTTG
GTAGTTGAATTTGACTTTTATATAATAGTGGATACACATGCACAGAAGTTACTAGAGAAGCAATAGCTATTTCTTTAAACATTCTTCAGG
CATCAGTACCATTTAAGGACAATTAGACATTCTAGTTTTACTAGGAGAAAGGTCAGTCATCTCTAACATTGTGTTGCAGAATTACACGAC
ACAAACATAAACACATTTCTGCCTATTAAACCAGTTTCTTTGTTTCTAAAGAGTTTAATGATACAGGTTTGCTATTTCCATTAGAGCATC
CTTTTTCTGGCCAATCGGACAAAATAGAGTTAGCAAAGCCCTCACAGCACCCTATGAAAAATCTCTGCTCTTATACAGGATTAGATGCAG
ACCTCATCTTGACCTAACATCTGTAACCAGGTAAGTGTATGAGTAGGAACACAGACAGCAGTACTGTATCAGCAAAATCTATCATATTAT
TTGAAATCACTGGATATAATATTAATTATAAAGTGTATGGTTCTCTCCAGTTGTTCACATACCAAATCCCAGTCAGTTCTCAGATTCAGA
TAGATGTATCTGCAATTTCTCCAAGCAGCTAAGAAAACCTTCAATGGTCAGTTCTGCTTGGTCATGGTATGACTCTTTTTTTTTTTTTTT
TTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAGTGGGGCAATCTCAGCTCACTGCAACCTCTGCCTCCCGGG
TTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGGAGCTGGGATTACAGGCACGTGCCACTGCGCCCGGCTGATGTATGACTCTTTTATCCA
GTAATCAAAACACATACGTACATACACACACATACCAGCCCAAAAGAGGTGTTAAAACATACATATTACACGTACTTTTTGGAGGGGTGG
GGTGGGGTGGGGTGGGGTGGGGTGGGGGTTATCTATCTCAAAATTACCTTTTGGTGCCTTGTCAAGCTGTGGAGTTTTGACCACACACAC
AAATTGAGCCAATGAACAATTTCAATGATCCTGAAAGTTCTTAAGTCTTATGAATAATTATCAAGAGTTCTGAGAAGTTATCTGTAAATC
AGCCTATGACACCATTTCTTGAGAGTTATGATTAAAGAAACAGCAATTATGCTTGAAGCGAACATACATCAACTAGTTAGAGCAAGGTCA
GCCTGTACAAGCTGACATAAATTATGAGAATGATGCTCTATCTCTAGAATTGGAATATTCTGTGGCTTCTTTGTAAAACTATAGATCTGG
TGGGTCATGGGAAGAAAGGGAGGGTGAACAAAAGATAAATATTACCTTTATTTTTTATCATCTTGAGCTTACTGTTTAGTTACCCCGTTT
CCCAAAACAGCACAACCTCTGTGACCAGTTAACTAAGAAATTATTTCCTTGGCAGCAAACCCAGAATTCCATCACTTACTCTTGTAAATA
GCAAGAAAGTAATTTACTAGCAGAGTTTGATAGAAAAATTCTTTAATGAAAACAAGTTTACACGTTGAACTTATGGCTTAACTAGAATAA

>49877_49877_1_LRRC19-SNAPC3_LRRC19_chr9_26996308_ENST00000380055_SNAPC3_chr9_15453038_ENST00000380821_length(amino acids)=315AA_BP=260
MKVTGITILFWPLSMILLSDKIQSSKREVQCNFTEKNYTLIPADIKKDVTILDLSYNQITLNGTDTRVLQTYFLLTELYLIENKVTILHN
NGFGNLSSLEILNICRNSIYVIQQGAFLGLNKLKQLYLCQNKIEQLNADVFVPLRSLKLLNLQGNLISYLDVPPLFHLELITLYGNLWNC
SCSLFNLQNWLNTSNVTLENENITMCSYPNSLQSYNIKTVPHKAECHSKFPSSVTEDLYIHFQPISNSIFNSSSNNLTRNSELSLSGQSP

--------------------------------------------------------------
>49877_49877_2_LRRC19-SNAPC3_LRRC19_chr9_26996309_ENST00000380055_SNAPC3_chr9_15453039_ENST00000380821_length(transcript)=5584nt_BP=895nt
AAAACAAAGTGAAATGTAATCATACGATGTACTTTTTTTAATGCCGTTGAAACAGAGTTAATTTCCTTTAGCACACAAGTCTTAGAGACA
AAAGAAAAAAAGGTCTGCAACATGAAAGTCACAGGCATCACAATCCTCTTTTGGCCCCTCTCCATGATATTATTATCAGACAAAATCCAG
TCTTCTAAAAGAGAAGTCCAATGTAATTTTACTGAAAAAAATTATACCTTGATTCCAGCAGATATCAAGAAAGATGTTACTATACTTGAT
CTCAGTTATAACCAAATTACTCTTAATGGTACAGACACAAGAGTTCTACAGACATACTTTTTACTCACAGAGCTCTATTTGATTGAGAAC
AAGGTTACTATCTTACATAATAACGGTTTTGGTAACCTCTCCAGTCTAGAAATTTTAAATATCTGTAGAAACTCCATCTATGTAATTCAA
CAGGGTGCATTTTTAGGCTTAAATAAACTAAAACAGTTATATCTCTGCCAAAACAAAATAGAACAACTGAATGCTGATGTATTTGTGCCT
CTAAGAAGCCTAAAACTTCTGAATCTGCAAGGCAATTTGATTAGCTATTTGGATGTACCACCACTATTTCATCTGGAATTAATAACTTTA
TATGGAAACCTATGGAACTGCTCTTGCAGTCTATTTAATTTGCAGAACTGGTTGAACACATCAAATGTGACATTAGAAAATGAGAACATC
ACCATGTGTAGCTACCCCAACAGCCTGCAGAGCTACAATATCAAAACAGTACCTCATAAGGCTGAATGCCACTCAAAATTTCCTTCATCA
GTAACTGAAGATCTTTATATTCATTTTCAGCCCATCAGCAATTCAATATTTAATAGCTCTTCGAACAACTTAACAAGAAATTCAGAACTA
TCATTGAGTGGTCAGAGTCCCATGATAGAGGCTATGGAAAGTTTCAGACTGCTAGAATGGAAGATTTCACCTTCAATGACTTGTGTATTA
AACTGGGTTTTCCTTACTTATACTGTCATCAGGGAGACTGTGAACATGTCATTGTCATTACTGACATAAGGCTTGTGCATCATGATGACT
GCTTGGATAGGACATTGTATCCCCTCCTTATCAAGAAGCATTGGCTATGGACCAGAAAATGTTTTGTTTGTAAAATGTATACAGCCAGAT
GGGTGACGAACAATGACAGTTTTGCACCAGAGGACCCATGCTTCTTTTGTGATGTTTGCTTCCGAATGCTGCACTATGATTCAGAAGGCA
ACAAACTGGGGGAATTCCTTGCTTATCCTTATGTTGATCCTGGAACCTTTAATTAAGAATAGCTACACTCACAAAAATACCCCCTCATGA
AATAACTGTTCTCTTGGATGGTTACCTTATTTCTAAGAAACGCCACTGAGGAACAGGATCCACTTTGAACAGTCCGCTAAAGCTATCAAA
AAAAAGTCCAAATGACAGATTTTCTTATAATGATAGTATTTAAATGTTTATAACATAGTTTAATTTTATATTTATTCCAGATAGTATTTA
ATTTAGTGCTTTTTACCCATTTTGAGTTGAGTTGTAGTACTTTATATATTCTGACTTTAAATCCTTTGTCAGACACACATATTCTTTCTC
CCAATCCATGCCTTCCCTATTCATTCTCTGTCCAGAGTTTTTTGCTAAAGATAGAATTATTAATGATACATCAAGTAGTGGAAGTGTTTT
GAAAATTCTTTGAAGAATGTGAGAGCTACACCTTCTACCATGAGGCTTCCAAGGTAAAGATCCTTCAAATAACTGTAATGGAAACTAGGG
AGAATGAATTATTTACAAATAAGACAAAATTAATAGCTTTGGGATTATTTATTTTTTGAGACAAAATCTCGCTCTTGTTGCCCAGGCTGG
AATACAGTGGCGCAATCTCAGCTCACTGCAGCCTCCGCCTCCCGGATTCAAGTGATTCTCCTGCCACAGCCTCCTGAGTAGCTGGGATTG
CAGGCACCTGGCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTAA
CCTCAGGCGATCCACCCGCCTAAGCCTCCCAAAATTTTGGGATCACAGGCGTGAGCCACCGCGCCCGGCTGCTTTGGGGGAATTTAATCT
TAGTGTGCTGTTTAGTAATGTTAGGTTTTGTTTTGGAGGAAACTAGGCATACAAGACATGTTAATAAGACTATGTGAATAATGAATTTAA
AAAGATCTTGAGTATATACTCATAACTCCAGAAATAACATTAACTTGAAGCTTTATTTCTTGACAAAAGCTTTATGAATGTTATGAGTTT
AAAATATGTCAATTTAATACTATGATTTAAAAAACAATAGCAGATTTCGTATGACTGTGGGGACATGGAAAAATCAAGATCCTATTGATT
GCTAGCTCTGGCTCACTTATTCTCCGGTAATGATACTATTGGATATATACCAAAATTATATAAGCAAAAAGAAAAAAAATAAGTTTTCCT
GGCCCAGGTCTTCCATTCTTCTGGTCCCCTTACTATAGTAATTCTAGTTACTCTCATCTTATTCTGAGGAAAAAAAAAAAAACCAAAACT
TTTTAAACTTATTTTTTGACATAGGGTCTTACTGTGTCACCCAGGCTGGAGTACAGTGGCGTGATCTTGGCTCACTGGAGCCCTGACCTC
CCTAGGCTCAGGTGATCCTCCCACCTCAGCCTACCGAGTAGCTGAGACATGGTGGCACAGGCCACCATGGCGGGCTAATTTTTTTATTTC
TTGTAGATACAGGGTTTCACTATGTTGCGCAGAATAGTCTCGAACTCCTGACCTCAAGTGATCCATCCGCCTTGGCCTCCCAGAGTGCTG
CGATTACAGGCATGAACCACAGCGCCCAGCAAAATAAACTTTCTTTATTTTCAGGTCTAGACCATCAGATAGATTTATTCAAATATTTTC
TGGGAACCTTTATGGGTAGAACATTTAATACTGTTTAGAAGACTTTTAGGAATACTATAGATTTCAAATGCATCATTTAAAATAAATAAA
TTCCACTTTCTCTCTCCTAGGTTGTATTTAAATTTGACTGAATATCTGGATGGCTAAGAACAGACATTTATCTTACACATGGAAAACTGA
CGAAACCTATAAGCCTATGTGTTTGACAGTGAAGTATGTTTTATGGACTTAAATGCCACAAACAGTTAAGTCCATTGGCTTGGAGATGAC
AAGCACGAGTTTCTGGTATGTCTAGTGTTCTCATTCACTGATTCAGTCAGTACACAGATAATCAGTATAGAGAACTTAAGAGGCTGGCTT
ATGTTATACCTAAATTTTTACTTTCTTGTATACAACAATGCTAAAATTGAGCAGATTGATAACTGCCAGCAAACCATAGATTTAAGATAA
ATGAATGATTTACCCAACCCTAAAATTCCATGGGTAAAAATTTTGATTCCTTTATTTTCAATACTGCGTTCCTTATAGGTCTTACATGCA
TATGCAAGGATATTTTATCTTATTCATTCATTTCATACTCTCAAAACACCAAACTTCAAAAAGTTAATTATTGTCATAATGCATTATTCC
ATGTGTGGTGTCAATACATTTTAGCGGACAAAGAAGAAACATGCCAGTTAAAACATTTCTGCTACTGGGATTCTTTATTAATTATTTGAG
AATGTTATTTTGCTAGTTCTTAAGGTTAAGTTTTTCATCAAAGACTCAGGTACCTATTATTGTTCCCTGGTGAAACTGAGGAGAAAAGTT
AATCAACCAGGTTACTCCCACAGTTTGCCCGTGTGTTATGTATCAGTTATACAGGTATCCCACCAAGTTCAAGTCAAAAGAAATTCCTAA
CTTTGTATATTTCTGGAGCTATAAAACCCCTGATTTAAGACAGCTTTTCTCTTTTTTCGAGGCAGCTTTTCTTTATGCTTATTTCAATCA
AATGTAACACGCCTGTCAAATTACATGTAACACATTAGCTAATGAAGATAGGCAACTGAAAATGTTGTCATGAACATGTCAACCTGCTTG
GTAGTTGAATTTGACTTTTATATAATAGTGGATACACATGCACAGAAGTTACTAGAGAAGCAATAGCTATTTCTTTAAACATTCTTCAGG
CATCAGTACCATTTAAGGACAATTAGACATTCTAGTTTTACTAGGAGAAAGGTCAGTCATCTCTAACATTGTGTTGCAGAATTACACGAC
ACAAACATAAACACATTTCTGCCTATTAAACCAGTTTCTTTGTTTCTAAAGAGTTTAATGATACAGGTTTGCTATTTCCATTAGAGCATC
CTTTTTCTGGCCAATCGGACAAAATAGAGTTAGCAAAGCCCTCACAGCACCCTATGAAAAATCTCTGCTCTTATACAGGATTAGATGCAG
ACCTCATCTTGACCTAACATCTGTAACCAGGTAAGTGTATGAGTAGGAACACAGACAGCAGTACTGTATCAGCAAAATCTATCATATTAT
TTGAAATCACTGGATATAATATTAATTATAAAGTGTATGGTTCTCTCCAGTTGTTCACATACCAAATCCCAGTCAGTTCTCAGATTCAGA
TAGATGTATCTGCAATTTCTCCAAGCAGCTAAGAAAACCTTCAATGGTCAGTTCTGCTTGGTCATGGTATGACTCTTTTTTTTTTTTTTT
TTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCTCCCAGGCTGGAGTGCAGTGGGGCAATCTCAGCTCACTGCAACCTCTGCCTCCCGGG
TTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGGAGCTGGGATTACAGGCACGTGCCACTGCGCCCGGCTGATGTATGACTCTTTTATCCA
GTAATCAAAACACATACGTACATACACACACATACCAGCCCAAAAGAGGTGTTAAAACATACATATTACACGTACTTTTTGGAGGGGTGG
GGTGGGGTGGGGTGGGGTGGGGTGGGGGTTATCTATCTCAAAATTACCTTTTGGTGCCTTGTCAAGCTGTGGAGTTTTGACCACACACAC
AAATTGAGCCAATGAACAATTTCAATGATCCTGAAAGTTCTTAAGTCTTATGAATAATTATCAAGAGTTCTGAGAAGTTATCTGTAAATC
AGCCTATGACACCATTTCTTGAGAGTTATGATTAAAGAAACAGCAATTATGCTTGAAGCGAACATACATCAACTAGTTAGAGCAAGGTCA
GCCTGTACAAGCTGACATAAATTATGAGAATGATGCTCTATCTCTAGAATTGGAATATTCTGTGGCTTCTTTGTAAAACTATAGATCTGG
TGGGTCATGGGAAGAAAGGGAGGGTGAACAAAAGATAAATATTACCTTTATTTTTTATCATCTTGAGCTTACTGTTTAGTTACCCCGTTT
CCCAAAACAGCACAACCTCTGTGACCAGTTAACTAAGAAATTATTTCCTTGGCAGCAAACCCAGAATTCCATCACTTACTCTTGTAAATA
GCAAGAAAGTAATTTACTAGCAGAGTTTGATAGAAAAATTCTTTAATGAAAACAAGTTTACACGTTGAACTTATGGCTTAACTAGAATAA

>49877_49877_2_LRRC19-SNAPC3_LRRC19_chr9_26996309_ENST00000380055_SNAPC3_chr9_15453039_ENST00000380821_length(amino acids)=315AA_BP=260
MKVTGITILFWPLSMILLSDKIQSSKREVQCNFTEKNYTLIPADIKKDVTILDLSYNQITLNGTDTRVLQTYFLLTELYLIENKVTILHN
NGFGNLSSLEILNICRNSIYVIQQGAFLGLNKLKQLYLCQNKIEQLNADVFVPLRSLKLLNLQGNLISYLDVPPLFHLELITLYGNLWNC
SCSLFNLQNWLNTSNVTLENENITMCSYPNSLQSYNIKTVPHKAECHSKFPSSVTEDLYIHFQPISNSIFNSSSNNLTRNSELSLSGQSP

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Top

Fusion Gene PPI Analysis for LRRC19-SNAPC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LRRC19-SNAPC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LRRC19-SNAPC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source