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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABL2-GPR161 (FusionGDB2 ID:500)

Fusion Gene Summary for ABL2-GPR161

Fusion gene summary

Fusion gene information	Fusion gene name: ABL2-GPR161
	Fusion gene ID: 500
		Hgene	Tgene
	Gene symbol	ABL2	GPR161
	Gene ID	27	23432
	Gene name	ABL proto-oncogene 2, non-receptor tyrosine kinase	G protein-coupled receptor 161
	Synonyms	ABLL\|ARG	RE2
	Cytomap	1q25.2	1q24.2
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2	G-protein coupled receptor 161G-protein coupled receptor RE2
	Modification date	20200327	20200313
	UniProtAcc	P42684	Q8N6U8
	Ensembl transtripts involved in fusion gene	ENST00000367623, ENST00000392043, ENST00000502732, ENST00000507173, ENST00000511413, ENST00000344730, ENST00000408940, ENST00000504405, ENST00000512653,	ENST00000367835, ENST00000367838, ENST00000271357, ENST00000361697, ENST00000367836, ENST00000485232, ENST00000537209, ENST00000539777, ENST00000546300,
Fusion gene scores	* DoF score	8 X 6 X 6=288	4 X 3 X 4=48
	# samples	8	4
	** MAII score	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABL2 [Title/Abstract] AND GPR161 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABL2(179198376)-GPR161(168083787), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABL2	GO:0018108	peptidyl-tyrosine phosphorylation	15886098
Hgene	ABL2	GO:0051353	positive regulation of oxidoreductase activity	12893824

Fusion gene breakpoints across ABL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GPR161 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-77-8131-01A	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-

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Fusion Gene ORF analysis for ABL2-GPR161

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000367623	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000367623	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000392043	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000392043	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000502732	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000502732	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000507173	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000507173	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000511413	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-5UTR	ENST00000511413	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000367623	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000367623	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000367623	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000367623	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000367623	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000367623	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000367623	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000392043	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000392043	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000392043	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000392043	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000392043	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000392043	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000392043	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000502732	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000502732	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000502732	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000502732	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000502732	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000502732	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000502732	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000507173	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000507173	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000507173	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000507173	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000507173	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000507173	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000507173	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000511413	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000511413	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000511413	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000511413	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000511413	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000511413	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
5CDS-intron	ENST00000511413	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000344730	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000344730	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000408940	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000408940	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000504405	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000504405	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000512653	ENST00000367835	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-5UTR	ENST00000512653	ENST00000367838	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000344730	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000344730	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000344730	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000344730	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000344730	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000344730	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000344730	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000408940	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000408940	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000408940	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000408940	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000408940	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000408940	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000408940	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000504405	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000504405	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000504405	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000504405	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000504405	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000504405	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000504405	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000512653	ENST00000271357	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000512653	ENST00000361697	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000512653	ENST00000367836	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000512653	ENST00000485232	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000512653	ENST00000537209	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000512653	ENST00000539777	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-
intron-intron	ENST00000512653	ENST00000546300	ABL2	chr1	179198376	-	GPR161	chr1	168083787	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ABL2-GPR161

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABL2-GPR161

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:179198376/:168083787)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABL2 P42684	GPR161 Q8N6U8
FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. {ECO:0000269\|PubMed:15735735, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:18945674}.	FUNCTION: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ABL2-GPR161

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABL2-GPR161

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABL2-GPR161

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABL2-GPR161

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source