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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LRRC7-RRP15 (FusionGDB2 ID:50039)

Fusion Gene Summary for LRRC7-RRP15

Fusion gene summary

Fusion gene information	Fusion gene name: LRRC7-RRP15
	Fusion gene ID: 50039
		Hgene	Tgene
	Gene symbol	LRRC7	RRP15
	Gene ID	57554	51018
	Gene name	leucine rich repeat containing 7	ribosomal RNA processing 15 homolog
	Synonyms	DENSIN	CGI-115\|KIAA0507
	Cytomap	1p31.1	1q41
	Type of gene	protein-coding	protein-coding
	Description	leucine-rich repeat-containing protein 7densin-180	RRP15-like proteinribosomal RNA-processing protein 15
	Modification date	20200313	20200313
	UniProtAcc	Q96NW7	RRP15
	Ensembl transtripts involved in fusion gene	ENST00000370958, ENST00000310961, ENST00000035383, ENST00000415775, ENST00000565615,	ENST00000491428, ENST00000366932,
Fusion gene scores	* DoF score	3 X 3 X 3=27	7 X 5 X 6=210
	# samples	3	9
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LRRC7 [Title/Abstract] AND RRP15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LRRC7(70034324)-RRP15(218504290), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LRRC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RRP15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-8257-01A	LRRC7	chr1	70034324	-	RRP15	chr1	218504290	+
ChimerDB4	PRAD	TCGA-HC-8257-01A	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
ChimerDB4	PRAD	TCGA-HC-8257	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+

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Fusion Gene ORF analysis for LRRC7-RRP15

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000370958	ENST00000491428	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
5UTR-3CDS	ENST00000310961	ENST00000366932	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
5UTR-intron	ENST00000310961	ENST00000491428	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
In-frame	ENST00000370958	ENST00000366932	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
intron-3CDS	ENST00000035383	ENST00000366932	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
intron-3CDS	ENST00000415775	ENST00000366932	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
intron-3CDS	ENST00000565615	ENST00000366932	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
intron-intron	ENST00000035383	ENST00000491428	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
intron-intron	ENST00000415775	ENST00000491428	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+
intron-intron	ENST00000565615	ENST00000491428	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000370958

LRRC7

chr1

70034324

ENST00000366932

RRP15

chr1

218504290

7228

192

5848

5450

132

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370958	ENST00000366932	LRRC7	chr1	70034324	+	RRP15	chr1	218504290	+	0.8248031	0.17519692

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Fusion Genomic Features for LRRC7-RRP15

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LRRC7	chr1	70034324	+	RRP15	chr1	218504289	+	2.72E-07	0.99999976
LRRC7	chr1	70034324	+	RRP15	chr1	218504289	+	2.72E-07	0.99999976
LRRC7	chr1	70034324	+	RRP15	chr1	218504289	+	2.72E-07	0.99999976
LRRC7	chr1	70034324	+	RRP15	chr1	218504289	+	2.72E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRC7-RRP15

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:70034324/chr1:218504290)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRRC7 Q96NW7	RRP15 RRP15
FUNCTION: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269\|PubMed:11729199}.	282

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

1445_1535

1538.0

Domain

PDZ

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

116_137

1538.0

Repeat

Note=LRR 5

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

139_161

1538.0

Repeat

Note=LRR 6

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

162_183

1538.0

Repeat

Note=LRR 7

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

185_206

1538.0

Repeat

Note=LRR 8

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

208_229

1538.0

Repeat

Note=LRR 9

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

231_253

1538.0

Repeat

Note=LRR 10

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

23_44

1538.0

Repeat

Note=LRR 1

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

254_275

1538.0

Repeat

Note=LRR 11

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

277_298

1538.0

Repeat

Note=LRR 12

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

300_321

1538.0

Repeat

Note=LRR 13

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

323_344

1538.0

Repeat

Note=LRR 14

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

346_367

1538.0

Repeat

Note=LRR 15

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

369_391

1538.0

Repeat

Note=LRR 16

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

392_413

1538.0

Repeat

Note=LRR 17

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

47_68

1538.0

Repeat

Note=LRR 2

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

70_91

1538.0

Repeat

Note=LRR 3

Hgene

LRRC7

chr1:70034324

chr1:218504290

ENST00000035383

93_114

1538.0

Repeat

Note=LRR 4

Tgene

RRP15

chr1:70034324

chr1:218504290

ENST00000366932

108_144

235

283.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for LRRC7-RRP15

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50039_50039_1_LRRC7-RRP15_LRRC7_chr1_70034324_ENST00000370958_RRP15_chr1_218504290_ENST00000366932_length(transcript)=7228nt_BP=192nt
GTCTAACGTGGCACCTTCCTGGATTCCCCTCTATCTCCTGTTCTTCCTACCTTCTACTCCTTCCCTCCTCTTCTCCTCCGAAGACCCTGG
CGCCCACTCCACTGCGGACCCCTGAACACTTAAGGAATAACCCTTGGCAGCTGCACGACTACGCTCTCCGAAACCTCATGGGCAGTTTCT
CCCGCCGGCGATACTGAAGTGAAATCAGAAGAAGGCCCAGGTTGGACGATCCTACGTGATGATTTCATGATGGGAGCATCTATGAAAGAC
TGGGACAAGGAAAGTGATGGGCCAGATGACAGCAGACCAGAATCTGCAAGTGACTCTGATACATAAAGCATCATAGGAAATACAATTGCA
GTCGTTTTATTTTTTCTAGAAAAATATGTCATCCTCTGATAGTTGGGGAATTATAAGGATACCATTTGTAAGAAAGCCAAAAGACTTTTG
CCAGATTTCATATTTCCCCTTTTCATGTACACTTTATATATACTTCATTAAAATTATATTTTAAACCCTTGTATAATTTTAAGCATTGTT
CCTCAGAACATTTGTAAAAGGATATATTTCTGCTTGACCAGCGAGATGTGCATTTTGCCAGGATCATATTGGTCATGTCTATTGGTGTAT
TATTTCAGTATCACCAATGTTTTCAGAAATACAGTACTAATTCATCATTAAACTCTTTGAAGTTAATATTTTTCTGCCTTCTAACTTATA
GACTCAACTATGTATCTGTAGTTTTTGGGAATGGTTGGTGTTTTTTGCTTTGTGTTGGGAAGTTATTGAGAAAACCTATATAATAAAATT
TAAAATTATAGTTTTTCAGATTTTGGGTCGTGATTTTAGTTTTAGGTAATCTGGAAGATATGATTTAAGAAACAACAGATTTCAACTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTGGCCCCGGATGGAATGCAGTGGCGTGATCTCGGCT
CACTGCAAGCACCGCCTCCCAGGTTCACGCCATTCTCCCACCTCAACCTCTCAAGTAGCTGGGACTACAGGTGCCTGCCACCACGCCCAG
CTAATTTTTTGTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACCCG
CCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCCAGATTTCAACTTTTATTTTATTTCCTTTCATTTATTA
AATAATATAAATAATGACAGATTTATTTTAGGTGTTAGCCTATTTTTGCATGAGAGATTTACAGAGGTGGAAATTCTCATGCTTAACTTA
TGCAATGAGACAATTTCTCAGGAAGCAAGTTTGACATGCTTTAGTCTCTCTCTTCTTTTTTTTCCTCCCAAATATTTGAGTTAGCTTAAA
TTCTTTTTTATGGACTGCCCAACCAGTGAATTGATGCACTTAGACAACAAGTAATCTGCAGCAGAATATTGCATCCAATTTGAGACTTGA
TTCCATATTATTGCCTTAAAGGCTATTAAATTGGGTGACTTTTAGTATCCAGCTGTTAAAAAGAGGAAAGACTGTTTAATATCATTCCAA
AATTTTTGTGAAATGTGGCCCAAGATCTAAAGTTTTTAAGGGAATTATTTTTAATAAATATGATCTGTCCCTTTTTGAAAAGGATCCATC
CCTTTTCATAATAAAAATAATTCCCTCCTACCACCCAGTTGCACATACTTGCATCTGTTATGTATTGAAGGATAATCCCCCCCAAAAAAA
CTATCCAAGAGCAGAGATGTTTATATTTTGAAACCCATTTGAGTGTTACAGTATTATATGACTAAAGCTGAATCAGTCTGTGGCCTGGTA
TTTGTTATCATAAAGGAAGATGTACACCTAAGGTATCAAGTGGTTAAAACAGCAAAGTACAAGATGCATTTTTGTATTTATTCTAACTTT
TGAACATTAGTGTCTTTCAGTATAAATAAATGTGAACAAATATACCTCAGTAGTAATACAGGAGAACTAAATATCCTGCTATAACTTAAT
ACAGATACATATTTCAATATGACTTAACAAACACACAATTTTGAAAAAAAAAAAAAAAAAGTGCAGCAACTTAAACACATTTTTCTCCCC
AGAACTAAGATTACACTTAATTTAATTTAATGTGTTTCTGCGTTATACTAGAGTTTTGCAGGAATTTTTCTGAATAGTACATTCACATGA
TAGATACGGATAAATACCTTATTTACTAAAATGTTTTGAAACATATTTTATAGTCCCTCATTTGATTTGAAAAAATTTGACAAGATCTTC
ACATTGAAAGTAAGGACGAGAATATTTGCAGATTTCCTTCGTTCCAAAATTATTTTATTCCAAAGAAAAATTGAGTTGCCACTATCAGGA
AAAAAAAAATGTATCACTTCTGTTAGAAGGCTATGAAGTATATATAAATTATATGACAATTTTTATCATATAGATTTGATATCTTCTATG
TATTCGTATTTTTGCATCTTGGGTATTAAGCAAAATACCATATGTATAAATATGAAACCAGGAATGTGCATATTTTAGAAACTAATTGTG
TATCTTAAGTGAATGTTTTGAGTAGTTCTGTCACCCCTATTCTAAATATTTTACCTACAACATTTAAATTATTCTGATATCAATCAGATA
AATAATCCGAGTGTATTTCATCTTTCTACATTGTCTTTGTGGTTTTTGTTTGTTTGTTTTTGAGACGGTCTCACACTGTCACCCAGGCTG
GAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCCAGCTATCCTCCCACCTCAGCCTCCCAAGTAGCTAGGACT
ACAGGTGTGCACCACCATGCCCAGCTAATTTTTTGTCTTTTTGATGTAGATGGGGTTACCCCATGTTGCCCAGGCTGGTTGTGAACTCCT
GAGCTCAAGGGATCCCCCCGCCTCTTGCCTCCCAAAGTGCTTGGATTACAGGTGTGAGCCACCATACCACCTGTCTTTGAATTTTTTAAC
GAGGGGAAAGAAAACTGCAATTCCTGCCTCCCCATTTATTTAAACATAACACCTAGGATTTTATTTTTGGTAACTACTTAGAATAATATA
GTAGGTTACTTATCTTCGGTTAGAAAGAACTATGGAAAATAGGAACCAATAATTTGGAAGTATTATTTCCTTATTTCATATATAGAAATA
ATTATCTTATTTCCTTATTTCATATATAGAATATTCTAGATACTTGGATGGCTGGGGTTGATGTTCTTAGTATTTATCATAGTTTAGCAT
TGGTTGTTATTTTTAAGCATCAGAATTTGAAAGCCAATGATAATACCTGATTAGGACTGAAAATAGAATTATCTTAGTAGTTTAGCACTT
TTTATAATGGAGTTGGAGCACTGAATTTATTTTCAAATTACCTAGAATTCTGCATTGCTCAAACATTATTCAATTGATTGCAAAATATAC
CTTGGAAACCCTTTGGATAGAACAGTTCAGAGGGTTACCACTAGTACTTAGAGCCTAAAGTCACTCAGTAGGAGGTTCTCAAAGGTCTAT
TTGAAGGCAATCCAATTTCTTTAAAATAAAATATTTTTTGCCTTTTAAAACAGATGGGTGAAGAAAGGGACGTATAAATTCTGGGAAACC
TCTTATGTTTTCCTCCCATTTCCTTCTATGTCTCCATTAATGTGCTAACTTGAAGGAATTTAACTTCAAGGAAAGTTGACTGATGAAGTT
TATGTAGAGCTGTGAATATTATAATTTGTCAATACTTTATTGATAATGTTAACTTTGTTTTTATTTGGAAACATTTTTTCCAGTTGACCA
AAGCAGAATTCATTCTGTTCTTCCCTCAAATTCATCTATTAGGATCAATGTGATTGACATTTATCTCCACTCTGCATGTCACTGATATGG
TATAGACGCTATAAGCCCTGTAGATATTATGGGTATGAAGACTATTTGAGGTGAATTGGCAGTGAGAGCAAATTTTGGAAACAGGAGAGA
GAACTACTTCGTGCCTATAAAAAGCTCTCTCACTCCTTCCCCAAGAAAACAGGAGTCTGAATTTTGGCCAGCTGGGTATTTGAATCTTAC
TGACTGTTGCAGCACTGGTAGTCCTGGTAAATTTTTTCAGTGGGCGAGCTTTTCTGAAATTTGATTAAACATATTAGTCAAGGGAATCTG
TGAATAGATTTAGAAGTAGAATGTTTGAGGTGGTTGACAAGACATTTAGAATTGTGATTAATGTTTTAATAAAATGCTAAGTTAGAATGA
ATAATCATAATTATATAGATGGAAGATATATTCTAACAGTTCTTAAATAATTTTAGATTCTCTAAATTTAGAGTGTTTTCTAGCTTAGAG
AGCAATATTAATATTTTTTACCTAGTCTACTGAACATAATTTCAGGGAGTTAGTATTTAGGACTTTTTACCTAGAGATGCGGTAAACCTT
TTAAATTTAAATTTGCTTTCTTAAAATACCTGTTCCAACATTGCTCACCTTTCTTCTCCCTCCTTTTTGCCCTCTCCTTCAGTGGGAGGA
GCACATATTCAGCTTTCTGTTAAACACTCTTTGGTTTTCAACTGAGTAAGGCAAGCAAGGATATATGTTAGAAGAGTGGGCATAATACTT
TATATTAAAATTATAGGGACTAAAAGTCTAAATCATTGCTGTCAATAGGACTTTTTTTGATGATGGAAATAATTTATGTCTGTGCTGTTC
AATATGGTAGCCACTCGCAGAGGTGACTACTGAGCATTTCACGTGTGGCTTGTGATACAGAGGAACTAAATTTTTAATTTTACTTAATTA
CTTTAAATTTTAAAAGTTACACGTGGCTAGTGGGTCTATCCCAACTATGAAGAGAATAAAGCTACAGAGCATCTATCTAGTCTAATGAAA
CAACAGTGAATTTGGGAATTGTAAATCTGTCTTAAGCTTTTTCCATAAACTTTTATTGATATAATTTAGGCATATACAAATACTGGTGAA
ATTTTATTGATTGAATTATTGTTGACTTTTTTTTCAGTATTTATATTTTTAAAAAGATATGTTTCTTTATAATTAACTTGTATTGTAGGG
TAACCATTGTCCTTAAATGTTAAGCCACTTAGTTAATAACAAATAGCATTTGGTTTTTTAGCATTATTTATCATCTGAGGCTTTCAGAAT
TAATGCACCAAACCTTAAATATTTTTGTTGTTCTCTAAAAGAATGGGTTTATGATGCACCAAAAGGACATTTTGAGAACTGCCGGAGCAA
CAGATACCACCATGTAAGGAGTGAATTCCCATGTTTTTCACTTATATCTAGAGGCCTACTTATTTAGGAGGTTTCCTAAGTAAGTGTATT
TAGTTGTAGGACCTTAGAGTTGCCTAGGTCCATTCTATTCTAGCATATACTCAACATACTGCCAGAGCAAATGTAGGTTGCAGATTCAGG
CAAAACACACACACACACACACACAAAACCCTGAAGAGCACAATGAGCATTATTAGCACAGCCAATTTAAAATGATGAGGTGTTAACCAC
ATTTGTATAAATAATAGTTTCTCTAACCCTGAATCATTATCCTGCATTTTTAATGCAATCGGTTCATAAACATCAAAGTGAAAACACCAA
ATTTGTAAGAGGTCAGGACCAACTGGGGCTCTAAATGGAGAGACAGCTGAGAGCTGTGTCCCTATGCGTGGGTGGCCTTGCAGCTGTTGA
TTCACCCTCAGGCTACCAGACAGTTGCCTCTTTGCATTTGCAGAACCAGACTTCAATCTTAGGTAAAAATGTATCCCTCCCATGGACAGG
ACATAAACAATAGATTGACATCAGCTCTGAAAACAGTGCAGCAGCCAGACTCAGCAGTTGCCCTGAAATACTGAGAAGTACCAAGCATAA
CATCAAGACTGTTTCTACACAATAATATTTGTCTTTGTACAGCAACACTGGGTTCTCTTAAGTATATTATAAATATAAAAGCTCAAAGTC
CAAAAGGTTCAATGTGATGATATCCTTCTCTACAAATGCCAGGAACACCAGGGTAGATTGCATGAGACATGACTGCCGTATCTTGGTCCT
TACTAGGATTCCCAAATATACTCCTTAATAACCAGTAAAGTTATATTTACACTGGACATTTTAAGAAATACCAGTGTTCGTTGTTAGATG
AGAGACAGCATAATTTTGGAATCACAACTGAGTTCAGAGTTCAGTTTTGAGTCCTACTAGTTTTGTTTCCTTGTGTAAGTTTCTTAACCT
TTGTAAGGCTAGCATGTAAATCAGATACAATAATATATAGTTCAGGGTGTAAAGATTGGATTAATGTATGCAGTGTCTATCTAGCACAGT
GCCTGTTATGTAGTAGCGTGTCAAGAGATGTTCTCTCTTATGCATTTGGAGGATTAGGTGCTGCACCTATAGGTTTCCATTCATTTCTCA
TCTATGTAATTCTGAGTCTTCCTTTTCTAGATAGAATTCCCCCCAACAAAAATTTAAAGTCTAACAGGTGGTAGGTGCTTATTGAGGCCC
AGCAATTCTACTTCTGGAAACCTTCCTCAGGAAAAGATTCTGATGACAGAAAATGCTGTGTGAACAGTATTATATAGAATTGTTTTTAAT
AGCAAGAAATTTTTTAAAACTTACAAGTTCAGTGATATGAGGACATTTACATAAACTATCGAACCACCAGTCTTCTGTCAATTCCTTTTA
AAATGATGGTTGTGAAGACTGATGAAAACACAGTGTCAATGATATGTTAACTGAAAAAGTAAGATTAAAAACATTATGGATAGTATAAGT
TTCTTAAATGCCAACAATGCATGAGGTGAATAGAATAAGACTTTTTTTTAAAGAATGTAATTTTTGACAGTCTGAAAAGACAGGCCTTAT
ATTTATATTGAGAAAAATGATCCTGACATTTAATGAGACACTAAAACAGTTTTTATTTTTTGCTTACTTATTCTGTTCTAGAATCCAAAC
TCTACATACTGTTTAATAGAGCATTATTGATATTAGCTGTATTAGATGACTGTATGAAGAGTCCTGTTTGCTAGAATCCTACTTTATCTT
TTAAGTTTTGCTAATTACCCTGCAATGAATGTTGAACATAAAAAATTTGACTCCCTTTCCATGTGTCCACTGTTTCCTTGTGCCTTTTGA

>50039_50039_1_LRRC7-RRP15_LRRC7_chr1_70034324_ENST00000370958_RRP15_chr1_218504290_ENST00000366932_length(amino acids)=132AA_BP=
MSMGGIHFYLRLKSGSANAKRQLSGSLRVNQQLQGHPRIGTQLSAVSPFRAPVGPDLLQIWCFHFDVYEPIALKMQDNDSGLEKLLFIQM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LRRC7-RRP15

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LRRC7-RRP15

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LRRC7-RRP15

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source