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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRFIP1-CARD10 (FusionGDB2 ID:50074)

Fusion Gene Summary for LRRFIP1-CARD10

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRFIP1-CARD10
Fusion gene ID: 50074
HgeneTgene
Gene symbol

LRRFIP1

CARD10

Gene ID

9208

29775

Gene nameLRR binding FLII interacting protein 1caspase recruitment domain family member 10
SynonymsFLAP-1|FLAP1|FLIIAP1|GCF-2|GCF2|HUFI-1|TRIPBIMP1|CARMA3
Cytomap

2q37.3

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat flightless-interacting protein 1GC-binding factor 2LRR FLII-interacting protein 1NEDD8-conjugating enzymeTAR RNA-interacting proteinleucine rich repeat (in FLII) interacting protein 1caspase recruitment domain-containing protein 10Bcl10 binding protein and activator of NFKBCARD-containing MAGUK 3 proteinCARD-containing MAGUK protein 3carma 3
Modification date2020031320200313
UniProtAcc

Q32MZ4

Q9BWT7

Ensembl transtripts involved in fusion geneENST00000244815, ENST00000289175, 
ENST00000308482, ENST00000392000, 
ENST00000468950, 		ENST00000251973, 
ENST00000403299, ENST00000406271, 
ENST00000494166, 
Fusion gene scores* DoF score16 X 12 X 9=17284 X 4 X 3=48
# samples 203
** MAII scorelog2(20/1728*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/48*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRFIP1 [Title/Abstract] AND CARD10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRFIP1(238668848)-CARD10(37915224), # samples:1
LRRFIP1(238668848)-CARD10(37912305), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRRFIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

14522076

TgeneCARD10

GO:0007250

activation of NF-kappaB-inducing kinase activity

11259443


check buttonFusion gene breakpoints across LRRFIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CARD10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THYMTCGA-XU-A92V-01ALRRFIP1chr2

238668848

-CARD10chr22

37912305

-
ChimerDB4THYMTCGA-XU-A92V-01ALRRFIP1chr2

238668848

+CARD10chr22

37915224

-


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Fusion Gene ORF analysis for LRRFIP1-CARD10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000244815ENST00000251973LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-5UTRENST00000244815ENST00000403299LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-5UTRENST00000289175ENST00000251973LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-5UTRENST00000289175ENST00000403299LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-5UTRENST00000308482ENST00000251973LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-5UTRENST00000308482ENST00000403299LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-5UTRENST00000392000ENST00000251973LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-5UTRENST00000392000ENST00000403299LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000244815ENST00000251973LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000244815ENST00000406271LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000244815ENST00000406271LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000244815ENST00000494166LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000244815ENST00000494166LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000289175ENST00000251973LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000289175ENST00000406271LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000289175ENST00000406271LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000289175ENST00000494166LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000289175ENST00000494166LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000308482ENST00000251973LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000308482ENST00000406271LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000308482ENST00000406271LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000308482ENST00000494166LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000308482ENST00000494166LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000392000ENST00000251973LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000392000ENST00000406271LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000392000ENST00000406271LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
5CDS-intronENST00000392000ENST00000494166LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
5CDS-intronENST00000392000ENST00000494166LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
In-frameENST00000244815ENST00000403299LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
In-frameENST00000289175ENST00000403299LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
In-frameENST00000308482ENST00000403299LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
In-frameENST00000392000ENST00000403299LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
intron-3CDSENST00000468950ENST00000403299LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
intron-5UTRENST00000468950ENST00000251973LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
intron-5UTRENST00000468950ENST00000403299LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
intron-intronENST00000468950ENST00000251973LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
intron-intronENST00000468950ENST00000406271LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
intron-intronENST00000468950ENST00000406271LRRFIP1chr2

238668848

+CARD10chr22

37915224

-
intron-intronENST00000468950ENST00000494166LRRFIP1chr2

238668848

-CARD10chr22

37912305

-
intron-intronENST00000468950ENST00000494166LRRFIP1chr2

238668848

+CARD10chr22

37915224

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308482LRRFIP1chr2238668848-ENST00000403299CARD10chr2237912305-505115282742531408
ENST00000289175LRRFIP1chr2238668848-ENST00000403299CARD10chr2237912305-4555103231137571148
ENST00000244815LRRFIP1chr2238668848-ENST00000403299CARD10chr2237912305-4580105724037821180
ENST00000392000LRRFIP1chr2238668848-ENST00000403299CARD10chr2237912305-4529100611737311204

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308482ENST00000403299LRRFIP1chr2238668848-CARD10chr2237912305-0.0036065050.9963935
ENST00000289175ENST00000403299LRRFIP1chr2238668848-CARD10chr2237912305-0.0066134120.99338657
ENST00000244815ENST00000403299LRRFIP1chr2238668848-CARD10chr2237912305-0.0065121850.99348783
ENST00000392000ENST00000403299LRRFIP1chr2238668848-CARD10chr2237912305-0.005934610.9940654

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Fusion Genomic Features for LRRFIP1-CARD10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRFIP1-CARD10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:238668848/chr22:37915224)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRFIP1

Q32MZ4

CARD10

Q9BWT7

FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.FUNCTION: Activates NF-kappa-B via BCL10 and IKK.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000244815-910128_250272785.0Coiled coilOntology_term=ECO:0000269
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000308482-1924128_250486641.0Coiled coilOntology_term=ECO:0000269
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000392000-1011128_250296809.0Coiled coilOntology_term=ECO:0000269
TgeneCARD10chr2:238668848chr22:37912305ENST00000251973120138_4561241033.0Coiled coilOntology_term=ECO:0000255
TgeneCARD10chr2:238668848chr22:37912305ENST00000403299221138_4561241033.0Coiled coilOntology_term=ECO:0000255
TgeneCARD10chr2:238668848chr22:37912305ENST00000251973120567_5741241033.0Compositional biasNote=Poly-Ser
TgeneCARD10chr2:238668848chr22:37912305ENST00000403299221567_5741241033.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000289175-78128_250240753.0Coiled coilOntology_term=ECO:0000269
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000244815-910567_593272785.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000289175-78567_593240753.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000308482-1924567_593486641.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000392000-1011567_593296809.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000244815-910485_584272785.0RegionNote=DNA-binding
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000289175-78485_584240753.0RegionNote=DNA-binding
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000308482-1924485_584486641.0RegionNote=DNA-binding
HgeneLRRFIP1chr2:238668848chr22:37912305ENST00000392000-1011485_584296809.0RegionNote=DNA-binding
TgeneCARD10chr2:238668848chr22:37912305ENST0000025197312023_1151241033.0DomainCARD
TgeneCARD10chr2:238668848chr22:37912305ENST0000040329922123_1151241033.0DomainCARD


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Fusion Gene Sequence for LRRFIP1-CARD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50074_50074_1_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000244815_CARD10_chr22_37912305_ENST00000403299_length(transcript)=4580nt_BP=1057nt
CCGAGCCCGACTCAGCCCGCGGCCACCTGCGCCCCGCCCCTGTCGGCCGCGCCCGAGCCCAGCGCCGCGAGCCGCTCCCCGGCGGGCTGG
CTCCTGGCCCCGGAAGCGCGAGCGTTCACTTAGCGGCGAGTGGCTCCGTCTCCGCGGACAGAGCGCGCGCCCCCTGGCCCGGCCCGCGAG
GGGCTCCCGGCGCGGTCCCCGAGCATTTCCCGCCGGGTGGAGCGGGCCGAGCCCGGCAGGATGACCAGCCCCGCGGCCGCTCAAAGCCGG
GAGATCGACTGTTTGAGCCCGGAAGCGCAGAAGCTGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATC
CGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAA
GACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATG
CCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAG
GCATCCATCAGGGAAATCAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAA
AAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAA
GAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGA
GAGGAAATGCTCGAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATAC
CAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGATGAGGAGGGGCCTGAGGGCCTG
ACCCAATTCTTGATGACAGAGGTGCGACGGCTGCGGGAAGCTCGCAAGAGCCAGCTGCAGCGGGAGCAGCAACTGCAGGCCCGGGGCCGG
GTGCTCGAGGAGGAGCGGGCAGGGCTGGAGCAGCGGCTGCGGGACCAGCAGCAGGCTCAGGAGCGCTGTCAACGGCTGCGGGAGGACTGG
GAGGCGGGCAGCCTGGAGCTGCTGCGGCTCAAGGATGAGAACTACATGATCGCCATGCGCCTGGCACAGCTCAGTGAGGAGAAGAACTCG
GCTGTACTTCGCAGCCGTGACCTGCAGCTGGCGGTGGATCAGCTCAAGCTCAAAGTGAGTCGGCTGGAGGAAGAGTGTGCACTGCTTCGA
AGGGCCAGGGGCCCGCCCCCTGGGGCAGAGGAGAAGGAGAAGGAGAAGGAGAAGGAGAAGGAGCCAGACAATGTGGACCTTGTCTCTGAG
CTGCGTGCTGAGAACCAGCGGCTGACGGCGTCACTGCGGGAGTTGCAGGAGGGCCTGCAGCAGGAGGCGAGCCGGCCGGGGGCCCCGGGC
TCCGAGCGCATCCTGCTGGACATCCTAGAGCATGACTGGCGGGAGGCGCAGGACAGCAGGCAGGAGCTGTGCCAGAAGCTGCATGCCGTG
CAGGGGGAGCTGCAGTGGGCCGAGGAGCTGCGCGACCAGTACCTGCAGGAGATGGAAGACCTGCGGCTCAAGCACCGCACGCTGCAGAAG
GACTGTGACCTGTACAAGCACCGCATGGCCACTGTCCTGGCCCAACTGGAGGAGATTGAGAAGGAGCGAGACCAGGCCATCCAGAGCCGT
GACCGGATCCAGTTGCAGTACTCACAGAGCCTCATCGAGAAGGACCAGTACCGCAAGCAGGTGCGGGGCCTGGAGGCGGAGCGGGATGAG
CTGCTGACAACGCTCACCAGCCTGGAGGGCACCAAGGCTCTGCTGGAGGTTCAGCTGCAGCGGGCCCAGGGTGGCACCTGCCTCAAGGCC
TGTGCCTCCTCCCATTCCCTGTGCTCCAACCTCAGCAGCACTTGGAGCCTGAGCGAGTTCCCCTCCCCTCTGGGAGGCCCAGAAGCAACT
GGGGAGGCAGCTGTCATGGGGGGACCTGAGCCTCACAACTCGGAGGAAGCCACAGACAGTGAAAAGGAGATCAATCGGCTCTCCATCCTG
CCCTTCCCCCCCAGTGCCGGCTCCATCCTCCGCCGGCAGCGTGAGGAAGACCCCGCACCCCCTAAGAGATCCTTCAGCAGCATGTCAGAC
ATCACAGGGAGTGTGACACTTAAGCCCTGGTCCCCTGGCCTCTCTTCGTCCTCATCCTCTGACAGCGTGTGGCCTTTGGGAAAGCCGGAA
GGCCTCCTGGCTCGGGGCTGTGGCCTGGACTTCCTCAACAGGTCTCTGGCTATTCGGGTGTCTGGCCGGAGCCCCCCAGGGGGCCCAGAG
CCGCAGGACAAGGGACCAGATGGACTGTCGTTTTATGGGGACAGATGGTCTGGGGCTGTGGTGCGCAGGGTGCTGTCTGGGCCTGGGTCC
GCCAGGATGGAACCAAGAGAGCAAAGGGTGGAAGCTGCTGGTCTGGAGGGGGCGTGCCTGGAAGCCGAGGCCCAGCAGAGAACCTTGCTC
TGGAATCAGGGGTCCACACTCCCCTCCCTGATGGACTCGAAGGCCTGCCAGTCCTTCCACGAGGCCCTAGAAGCCTGGGCAAAGGGACCA
GGTGCCGAGCCCTTCTACATTCGTGCCAACCTCACCTTGCCTGAGAGGGCAGATCCCCATGCCCTTTGCGTGAAAGCCCAAGAGATCCTT
CGACTGGTGGACTCGGCATACAAGCGGAGGCAGGAATGGTTCTGCACCCGGGTTGACCCCCTCACTCTGCGGGACCTGGACCGGGGCACC
GTGCCCAATTATCAGAGAGCCCAGCAGCTCCTAGAAGTTCAGGAGAAATGCCTGCCCTCCAGCCGGCACCGAGGCCCCCGCAGTAATCTG
AAGAAGAGAGCCCTGGACCAGCTGCGGCTGGTGAGGCCCAAGCCCGTGGGGGCGCCTGCAGGGGACTCCCCGGATCAGCTGCTGCTGGAG
CCCTGTGCAGAGCCGGAGCGGAGCCTCAGACCCTACAGTTTGGTGCGGCCGCTACTGGTGTCTGCCCTGCGGCCCGTGGTGCTGTTGCCT
GAGTGCCTGGCGCCCCGGCTCATCCGTAACCTGCTAGACCTGCCCAGCTCCCGGCTGGACTTCCAAGTGTGCCCAGCGGAAAGCCTCTCT
GGGGAGGAACTGTGCCCATCCTCAGCGCCTGGAGCCCCCAAGGCTCAGCCTGCCACCCCTGGGCTAGGCAGCAGGATCCGGGCCATCCAG
GAGTCTGTTGGGAAGAAGCACTGCCTGCTGGAGCTGGGTGCTCGGGGTGTGCGGGAGCTGGTGCAGAACGAGATCTACCCCATCGTCATC
CACGTGGAGGTGACTGAGAAGAATGTCCGGGAAGTCAGGGGTCTGCTGGGCCGGCCGGGCTGGCGGGACTCAGAGCTGCTGCGGCAGTGC
CGTGGCTCAGAGCAGGTGCTCTGGGGGCTGCCCTGCTCCTGGGTGCAGGTGCCCGCCCATGAGTGGGGACACGCAGAGGAGCTGGCCAAG
GTGGTGCGCGGCCGCATCCTGCAGGAGCAGGCCCGCCTCGTGTGGGTGGAGTGCGGCAGCAGCAGAGGCTGCCCCAGCAGCAGTGAGGCC
TGAGGCTCATCTGATACCTGCACCTTCTCCCCAAGCCAGCGTGGACCCTGGTGTCTATGGTGAAGCTGGGCCCTCCCACCCTGAGCCTTC
CTAGACCCTTGGACTCTCAGATGCAGGGCCCTTGGCTCTGGCCTCTCACCCCCAAGGCTGTCTCTGGCCCTGCCGAGCCTATGGGAGTCC
CGGGACAGAGTGCCCACTCCCCTCTACTTGCTGCTCTGGGCCTCCCCACCTTTCCTGGGGTCTCCACATTCCCACTAGTGGGTCTTATGT
GTGTCTGTGTCTTCTCCTTAAACACTCGCCCTGGAGTCTGTTCTCACACCTGTGCGCAGGTTTGCACACTCAAGTTCTCATGGGCAGGCT
CAGGTCTGTCCCGCTGCCCTGGGCACGAGGTCTCCTGAGGACCTGGGCCTGTTCTGCTCCTAGGAGACCTGAGCCCGTTACCGCGTGACT
CCCACCATCCAGCTCGCGCTCCTCGTGGATTCAGCCATGCATGGACTGGGGTGTTCCCTGGCCCATGGTCACCTGTGCCCCTCGTGTCTC
CTCACATGGGTGTCTGTGGTTCTCTCCTGTGTAAATGTCACGCCCCACCCCTGTTTCATGTGGGCACTAACACGTGTGCGTTCCTGGCGG
GCACACTCAGGACCGTGCCTCACAGGGCCCACTCCCTGCCTATGCCTCCCTCTTGGGGGGCCGAGGAGGGCGGCTGCTCTGTCATGAGAA

>50074_50074_1_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000244815_CARD10_chr22_37912305_ENST00000403299_length(amino acids)=1180AA_BP=272
MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEK
DFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEE
QLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDG
TLDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMR
LAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQ
QEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIE
KERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEF
PSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSS
DSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACL
EAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDP
LTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLV
SALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVREL
VQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGS

--------------------------------------------------------------
>50074_50074_2_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000289175_CARD10_chr22_37912305_ENST00000403299_length(transcript)=4555nt_BP=1032nt
GCGTGGGGGGCGGGGCGGGCCGTGGGACGGGCGGAGGCGCCCGAGTCCCGCTTCCCCGGCGCCCTTCCACCCCGAGCCCGACTCAGCCCG
CGGCCACCTGCGCCCCGCCCCTGTCGGCCGCGCCCGAGCCCAGCGCCGCGAGCCGCTCCCCGGCGGGCTGGCTCCTGGCCCCGGAAGCGC
GAGCGTTCACTTAGCGGCGAGTGGCTCCGTCTCCGCGGACAGAGCGCGCGCCCCCTGGCCCGGCCCGCGAGGGGCTCCCGGCGCGGTCCC
CGAGCATTTCCCGCCGGGTGGAGCGGGCCGAGCCCGGCAGGATGACCAGCCCCGCGGCCGCTCAAAGCCGGGAGATCGACTGTTTGAGCC
CGGAAGCGCAGAAGCTGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGC
GGCAGCAGAAGGAGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGG
CCTCTCTGGGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGACT
CTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTG
ATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGG
AAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGAAACATGGAA
TAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAG
AAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGATGAGGAGGGGCCTGAGGGCCTGACCCAATTCTTGATGACAGAGGTGC
GACGGCTGCGGGAAGCTCGCAAGAGCCAGCTGCAGCGGGAGCAGCAACTGCAGGCCCGGGGCCGGGTGCTCGAGGAGGAGCGGGCAGGGC
TGGAGCAGCGGCTGCGGGACCAGCAGCAGGCTCAGGAGCGCTGTCAACGGCTGCGGGAGGACTGGGAGGCGGGCAGCCTGGAGCTGCTGC
GGCTCAAGGATGAGAACTACATGATCGCCATGCGCCTGGCACAGCTCAGTGAGGAGAAGAACTCGGCTGTACTTCGCAGCCGTGACCTGC
AGCTGGCGGTGGATCAGCTCAAGCTCAAAGTGAGTCGGCTGGAGGAAGAGTGTGCACTGCTTCGAAGGGCCAGGGGCCCGCCCCCTGGGG
CAGAGGAGAAGGAGAAGGAGAAGGAGAAGGAGAAGGAGCCAGACAATGTGGACCTTGTCTCTGAGCTGCGTGCTGAGAACCAGCGGCTGA
CGGCGTCACTGCGGGAGTTGCAGGAGGGCCTGCAGCAGGAGGCGAGCCGGCCGGGGGCCCCGGGCTCCGAGCGCATCCTGCTGGACATCC
TAGAGCATGACTGGCGGGAGGCGCAGGACAGCAGGCAGGAGCTGTGCCAGAAGCTGCATGCCGTGCAGGGGGAGCTGCAGTGGGCCGAGG
AGCTGCGCGACCAGTACCTGCAGGAGATGGAAGACCTGCGGCTCAAGCACCGCACGCTGCAGAAGGACTGTGACCTGTACAAGCACCGCA
TGGCCACTGTCCTGGCCCAACTGGAGGAGATTGAGAAGGAGCGAGACCAGGCCATCCAGAGCCGTGACCGGATCCAGTTGCAGTACTCAC
AGAGCCTCATCGAGAAGGACCAGTACCGCAAGCAGGTGCGGGGCCTGGAGGCGGAGCGGGATGAGCTGCTGACAACGCTCACCAGCCTGG
AGGGCACCAAGGCTCTGCTGGAGGTTCAGCTGCAGCGGGCCCAGGGTGGCACCTGCCTCAAGGCCTGTGCCTCCTCCCATTCCCTGTGCT
CCAACCTCAGCAGCACTTGGAGCCTGAGCGAGTTCCCCTCCCCTCTGGGAGGCCCAGAAGCAACTGGGGAGGCAGCTGTCATGGGGGGAC
CTGAGCCTCACAACTCGGAGGAAGCCACAGACAGTGAAAAGGAGATCAATCGGCTCTCCATCCTGCCCTTCCCCCCCAGTGCCGGCTCCA
TCCTCCGCCGGCAGCGTGAGGAAGACCCCGCACCCCCTAAGAGATCCTTCAGCAGCATGTCAGACATCACAGGGAGTGTGACACTTAAGC
CCTGGTCCCCTGGCCTCTCTTCGTCCTCATCCTCTGACAGCGTGTGGCCTTTGGGAAAGCCGGAAGGCCTCCTGGCTCGGGGCTGTGGCC
TGGACTTCCTCAACAGGTCTCTGGCTATTCGGGTGTCTGGCCGGAGCCCCCCAGGGGGCCCAGAGCCGCAGGACAAGGGACCAGATGGAC
TGTCGTTTTATGGGGACAGATGGTCTGGGGCTGTGGTGCGCAGGGTGCTGTCTGGGCCTGGGTCCGCCAGGATGGAACCAAGAGAGCAAA
GGGTGGAAGCTGCTGGTCTGGAGGGGGCGTGCCTGGAAGCCGAGGCCCAGCAGAGAACCTTGCTCTGGAATCAGGGGTCCACACTCCCCT
CCCTGATGGACTCGAAGGCCTGCCAGTCCTTCCACGAGGCCCTAGAAGCCTGGGCAAAGGGACCAGGTGCCGAGCCCTTCTACATTCGTG
CCAACCTCACCTTGCCTGAGAGGGCAGATCCCCATGCCCTTTGCGTGAAAGCCCAAGAGATCCTTCGACTGGTGGACTCGGCATACAAGC
GGAGGCAGGAATGGTTCTGCACCCGGGTTGACCCCCTCACTCTGCGGGACCTGGACCGGGGCACCGTGCCCAATTATCAGAGAGCCCAGC
AGCTCCTAGAAGTTCAGGAGAAATGCCTGCCCTCCAGCCGGCACCGAGGCCCCCGCAGTAATCTGAAGAAGAGAGCCCTGGACCAGCTGC
GGCTGGTGAGGCCCAAGCCCGTGGGGGCGCCTGCAGGGGACTCCCCGGATCAGCTGCTGCTGGAGCCCTGTGCAGAGCCGGAGCGGAGCC
TCAGACCCTACAGTTTGGTGCGGCCGCTACTGGTGTCTGCCCTGCGGCCCGTGGTGCTGTTGCCTGAGTGCCTGGCGCCCCGGCTCATCC
GTAACCTGCTAGACCTGCCCAGCTCCCGGCTGGACTTCCAAGTGTGCCCAGCGGAAAGCCTCTCTGGGGAGGAACTGTGCCCATCCTCAG
CGCCTGGAGCCCCCAAGGCTCAGCCTGCCACCCCTGGGCTAGGCAGCAGGATCCGGGCCATCCAGGAGTCTGTTGGGAAGAAGCACTGCC
TGCTGGAGCTGGGTGCTCGGGGTGTGCGGGAGCTGGTGCAGAACGAGATCTACCCCATCGTCATCCACGTGGAGGTGACTGAGAAGAATG
TCCGGGAAGTCAGGGGTCTGCTGGGCCGGCCGGGCTGGCGGGACTCAGAGCTGCTGCGGCAGTGCCGTGGCTCAGAGCAGGTGCTCTGGG
GGCTGCCCTGCTCCTGGGTGCAGGTGCCCGCCCATGAGTGGGGACACGCAGAGGAGCTGGCCAAGGTGGTGCGCGGCCGCATCCTGCAGG
AGCAGGCCCGCCTCGTGTGGGTGGAGTGCGGCAGCAGCAGAGGCTGCCCCAGCAGCAGTGAGGCCTGAGGCTCATCTGATACCTGCACCT
TCTCCCCAAGCCAGCGTGGACCCTGGTGTCTATGGTGAAGCTGGGCCCTCCCACCCTGAGCCTTCCTAGACCCTTGGACTCTCAGATGCA
GGGCCCTTGGCTCTGGCCTCTCACCCCCAAGGCTGTCTCTGGCCCTGCCGAGCCTATGGGAGTCCCGGGACAGAGTGCCCACTCCCCTCT
ACTTGCTGCTCTGGGCCTCCCCACCTTTCCTGGGGTCTCCACATTCCCACTAGTGGGTCTTATGTGTGTCTGTGTCTTCTCCTTAAACAC
TCGCCCTGGAGTCTGTTCTCACACCTGTGCGCAGGTTTGCACACTCAAGTTCTCATGGGCAGGCTCAGGTCTGTCCCGCTGCCCTGGGCA
CGAGGTCTCCTGAGGACCTGGGCCTGTTCTGCTCCTAGGAGACCTGAGCCCGTTACCGCGTGACTCCCACCATCCAGCTCGCGCTCCTCG
TGGATTCAGCCATGCATGGACTGGGGTGTTCCCTGGCCCATGGTCACCTGTGCCCCTCGTGTCTCCTCACATGGGTGTCTGTGGTTCTCT
CCTGTGTAAATGTCACGCCCCACCCCTGTTTCATGTGGGCACTAACACGTGTGCGTTCCTGGCGGGCACACTCAGGACCGTGCCTCACAG
GGCCCACTCCCTGCCTATGCCTCCCTCTTGGGGGGCCGAGGAGGGCGGCTGCTCTGTCATGAGAATGTACGGCCCGTGGATGATTAACGG

>50074_50074_2_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000289175_CARD10_chr22_37912305_ENST00000403299_length(amino acids)=1148AA_BP=240
MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGD
TSISIDTEASIREIKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAE
VKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDEEGPEGLTQFLMTEVRRLREARKSQLQRE
QQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRL
EEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQE
LCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVR
GLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEK
EINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSG
RSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEA
LEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSR
HRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQ
VCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWR

--------------------------------------------------------------
>50074_50074_3_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000308482_CARD10_chr22_37912305_ENST00000403299_length(transcript)=5051nt_BP=1528nt
GGGGCCGGGCCGGGGCGGCGCGAGCGGCTGGAGCAACGGGCCCCGCGGCAGCTGCGGGCGACGCGGTCGATGGACATGGGCACCCAGGGA
TCGGGGCGCAAGCGGCTCCCCAACCGGGAGCGGCTCACGGCGGAGGACGACGCGCTCAACCAGATCGCGCGGGAGGCGGAAGCCCGGCTC
GCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAGATCTATCAGGTCCAAAAG
AAATATTATGGGCTGGATACAAAATGGGGTGACATCGAGCAGTGGATGGAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACA
TCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGCCTGAGGTCGCAGCCTGACTTGGAGTATGGGGGTCCTTACGCC
TGGACAAATGGTTATGATGGAGAATTGTATGGATCACAGTCCCTGAATAGAAGATCTGGCAGGCCCTCCTGTCTGTACAGCGCTGCCCGG
CCTTCGGGGAGTTACCGGGCGTCTGTGTTGGATGAAGGCAGCTTCGGTGGGACCCGACGGGGCAGCACCTCCGGCTCCCGTGCTCCCTCG
GAGTACAGCGGCCACCTCAACTCCAGCTCCCGCGCCTCCTCCAGGGCCAGCTCGGCCCGGGCCAGCCCTGTGGTAGAAGAGAGACCAGAA
AAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTGGGTGGGACTTCCTCTCGGAGAGGC
AGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAGTTAAAGGACCAGATTCAGGATGTA
GAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATATAAGAAGGCTATGGTTTCCAATGCT
CAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAGCTTGAAGAACAGCTGGCTGAATCT
AGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAATTTCAGTTTGCTGAAGTCAAGGAG
GCCCTGAAGCAAAGAGAGGAAATGCTCGAGGAAATCCGACAGCTACAGCAGAAACAGGCGAGTTCTATCAGGGAGATTTCTGATCTTCAG
GAAACAATAGAGTGGAAAGACAAAAAGATAGGGGCATTAGAGAGGCAGAAAGAGTTCTTTGATTCCGTAAGGAGTGAACGGGATGATCTT
AGAGAAGAAGTAGTCATGCTGAAAGAGGAATTAAAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACCAATGGAGAGACTTCCGAC
ACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACAGGGGATGGGACCCTAGAT
GAGGAGGGGCCTGAGGGCCTGACCCAATTCTTGATGACAGAGGTGCGACGGCTGCGGGAAGCTCGCAAGAGCCAGCTGCAGCGGGAGCAG
CAACTGCAGGCCCGGGGCCGGGTGCTCGAGGAGGAGCGGGCAGGGCTGGAGCAGCGGCTGCGGGACCAGCAGCAGGCTCAGGAGCGCTGT
CAACGGCTGCGGGAGGACTGGGAGGCGGGCAGCCTGGAGCTGCTGCGGCTCAAGGATGAGAACTACATGATCGCCATGCGCCTGGCACAG
CTCAGTGAGGAGAAGAACTCGGCTGTACTTCGCAGCCGTGACCTGCAGCTGGCGGTGGATCAGCTCAAGCTCAAAGTGAGTCGGCTGGAG
GAAGAGTGTGCACTGCTTCGAAGGGCCAGGGGCCCGCCCCCTGGGGCAGAGGAGAAGGAGAAGGAGAAGGAGAAGGAGAAGGAGCCAGAC
AATGTGGACCTTGTCTCTGAGCTGCGTGCTGAGAACCAGCGGCTGACGGCGTCACTGCGGGAGTTGCAGGAGGGCCTGCAGCAGGAGGCG
AGCCGGCCGGGGGCCCCGGGCTCCGAGCGCATCCTGCTGGACATCCTAGAGCATGACTGGCGGGAGGCGCAGGACAGCAGGCAGGAGCTG
TGCCAGAAGCTGCATGCCGTGCAGGGGGAGCTGCAGTGGGCCGAGGAGCTGCGCGACCAGTACCTGCAGGAGATGGAAGACCTGCGGCTC
AAGCACCGCACGCTGCAGAAGGACTGTGACCTGTACAAGCACCGCATGGCCACTGTCCTGGCCCAACTGGAGGAGATTGAGAAGGAGCGA
GACCAGGCCATCCAGAGCCGTGACCGGATCCAGTTGCAGTACTCACAGAGCCTCATCGAGAAGGACCAGTACCGCAAGCAGGTGCGGGGC
CTGGAGGCGGAGCGGGATGAGCTGCTGACAACGCTCACCAGCCTGGAGGGCACCAAGGCTCTGCTGGAGGTTCAGCTGCAGCGGGCCCAG
GGTGGCACCTGCCTCAAGGCCTGTGCCTCCTCCCATTCCCTGTGCTCCAACCTCAGCAGCACTTGGAGCCTGAGCGAGTTCCCCTCCCCT
CTGGGAGGCCCAGAAGCAACTGGGGAGGCAGCTGTCATGGGGGGACCTGAGCCTCACAACTCGGAGGAAGCCACAGACAGTGAAAAGGAG
ATCAATCGGCTCTCCATCCTGCCCTTCCCCCCCAGTGCCGGCTCCATCCTCCGCCGGCAGCGTGAGGAAGACCCCGCACCCCCTAAGAGA
TCCTTCAGCAGCATGTCAGACATCACAGGGAGTGTGACACTTAAGCCCTGGTCCCCTGGCCTCTCTTCGTCCTCATCCTCTGACAGCGTG
TGGCCTTTGGGAAAGCCGGAAGGCCTCCTGGCTCGGGGCTGTGGCCTGGACTTCCTCAACAGGTCTCTGGCTATTCGGGTGTCTGGCCGG
AGCCCCCCAGGGGGCCCAGAGCCGCAGGACAAGGGACCAGATGGACTGTCGTTTTATGGGGACAGATGGTCTGGGGCTGTGGTGCGCAGG
GTGCTGTCTGGGCCTGGGTCCGCCAGGATGGAACCAAGAGAGCAAAGGGTGGAAGCTGCTGGTCTGGAGGGGGCGTGCCTGGAAGCCGAG
GCCCAGCAGAGAACCTTGCTCTGGAATCAGGGGTCCACACTCCCCTCCCTGATGGACTCGAAGGCCTGCCAGTCCTTCCACGAGGCCCTA
GAAGCCTGGGCAAAGGGACCAGGTGCCGAGCCCTTCTACATTCGTGCCAACCTCACCTTGCCTGAGAGGGCAGATCCCCATGCCCTTTGC
GTGAAAGCCCAAGAGATCCTTCGACTGGTGGACTCGGCATACAAGCGGAGGCAGGAATGGTTCTGCACCCGGGTTGACCCCCTCACTCTG
CGGGACCTGGACCGGGGCACCGTGCCCAATTATCAGAGAGCCCAGCAGCTCCTAGAAGTTCAGGAGAAATGCCTGCCCTCCAGCCGGCAC
CGAGGCCCCCGCAGTAATCTGAAGAAGAGAGCCCTGGACCAGCTGCGGCTGGTGAGGCCCAAGCCCGTGGGGGCGCCTGCAGGGGACTCC
CCGGATCAGCTGCTGCTGGAGCCCTGTGCAGAGCCGGAGCGGAGCCTCAGACCCTACAGTTTGGTGCGGCCGCTACTGGTGTCTGCCCTG
CGGCCCGTGGTGCTGTTGCCTGAGTGCCTGGCGCCCCGGCTCATCCGTAACCTGCTAGACCTGCCCAGCTCCCGGCTGGACTTCCAAGTG
TGCCCAGCGGAAAGCCTCTCTGGGGAGGAACTGTGCCCATCCTCAGCGCCTGGAGCCCCCAAGGCTCAGCCTGCCACCCCTGGGCTAGGC
AGCAGGATCCGGGCCATCCAGGAGTCTGTTGGGAAGAAGCACTGCCTGCTGGAGCTGGGTGCTCGGGGTGTGCGGGAGCTGGTGCAGAAC
GAGATCTACCCCATCGTCATCCACGTGGAGGTGACTGAGAAGAATGTCCGGGAAGTCAGGGGTCTGCTGGGCCGGCCGGGCTGGCGGGAC
TCAGAGCTGCTGCGGCAGTGCCGTGGCTCAGAGCAGGTGCTCTGGGGGCTGCCCTGCTCCTGGGTGCAGGTGCCCGCCCATGAGTGGGGA
CACGCAGAGGAGCTGGCCAAGGTGGTGCGCGGCCGCATCCTGCAGGAGCAGGCCCGCCTCGTGTGGGTGGAGTGCGGCAGCAGCAGAGGC
TGCCCCAGCAGCAGTGAGGCCTGAGGCTCATCTGATACCTGCACCTTCTCCCCAAGCCAGCGTGGACCCTGGTGTCTATGGTGAAGCTGG
GCCCTCCCACCCTGAGCCTTCCTAGACCCTTGGACTCTCAGATGCAGGGCCCTTGGCTCTGGCCTCTCACCCCCAAGGCTGTCTCTGGCC
CTGCCGAGCCTATGGGAGTCCCGGGACAGAGTGCCCACTCCCCTCTACTTGCTGCTCTGGGCCTCCCCACCTTTCCTGGGGTCTCCACAT
TCCCACTAGTGGGTCTTATGTGTGTCTGTGTCTTCTCCTTAAACACTCGCCCTGGAGTCTGTTCTCACACCTGTGCGCAGGTTTGCACAC
TCAAGTTCTCATGGGCAGGCTCAGGTCTGTCCCGCTGCCCTGGGCACGAGGTCTCCTGAGGACCTGGGCCTGTTCTGCTCCTAGGAGACC
TGAGCCCGTTACCGCGTGACTCCCACCATCCAGCTCGCGCTCCTCGTGGATTCAGCCATGCATGGACTGGGGTGTTCCCTGGCCCATGGT
CACCTGTGCCCCTCGTGTCTCCTCACATGGGTGTCTGTGGTTCTCTCCTGTGTAAATGTCACGCCCCACCCCTGTTTCATGTGGGCACTA
ACACGTGTGCGTTCCTGGCGGGCACACTCAGGACCGTGCCTCACAGGGCCCACTCCCTGCCTATGCCTCCCTCTTGGGGGGCCGAGGAGG
GCGGCTGCTCTGTCATGAGAATGTACGGCCCGTGGATGATTAACGGGCCTTTTTCACTTAGAAGCTGCACATTATGGAGCATTAAACACT

>50074_50074_3_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000308482_CARD10_chr22_37912305_ENST00000403299_length(amino acids)=1408AA_BP=500
MEQRAPRQLRATRSMDMGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKW
GDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASV
LDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISID
TEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNK
EFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKE
ELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVL
EEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRA
RGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQG
ELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELL
TTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPF
PPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQ
DKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGA
EPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKK
RALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGE
ELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRG

--------------------------------------------------------------
>50074_50074_4_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000392000_CARD10_chr22_37912305_ENST00000403299_length(transcript)=4529nt_BP=1006nt
CGGCGAGTGGCTCCGTCTCCGCGGACAGAGCGCGCGCCCCCTGGCCCGGCCCGCGAGGGGCTCCCGGCGCGGTCCCCGAGCATTTCCCGC
CGGGTGGAGCGGGCCGAGCCCGGCAGGATGACCAGCCCCGCGGCCGCTCAAAGCCGGGAGATCGACTGTTTGAGCCCGGAAGCGCAGAAG
CTGGCGGAAGCCCGGCTCGCTGCAAAACGGGCGGCCCGCGCGGAGGCTCGCGAGATCCGCATGAAGGAGCTGGAGCGGCAGCAGAAGGAG
GAAGACAGTGAGCGCTACTCTCGTAGATCCAGAAGAAACACATCGGCTTCTGATGAAGACGAGCGCATGTCAGTGGGTAGTCGTGGAAGC
CTGAGGGTAGAAGAGAGACCAGAAAAAGATTTTACTGAGAAGGGGTCTCGTAACATGCCGGGCCTGTCTGCAGCCACGCTGGCCTCTCTG
GGTGGGACTTCCTCTCGGAGAGGCAGCGGAGACACCTCCATCTCCATCGACACCGAGGCATCCATCAGGGAAATCAAGGAACTCAATGAG
TTAAAGGACCAGATTCAGGATGTAGAAGGCAAATACATGCAGGGATTGAAAGAGATGAAGGACTCTCTAGCAGAAGTTGAAGAGAAATAT
AAGAAGGCTATGGTTTCCAATGCTCAGCTAGACAATGAAAAGACAAACTTCATGTACCAGGTTGATACCCTAAAAGATATGTTGCTGGAG
CTTGAAGAACAGCTGGCTGAATCTAGGCGGCAGTACGAAGAGAAAAACAAAGAATTTGAAAGGGAAAAACACGCCCACAGTATACTGCAA
TTTCAGTTTGCTGAAGTCAAGGAGGCCCTGAAGCAAAGAGAGGAAATGCTCGAGAAACATGGAATAATCCTAAATTCAGAAATAGCTACC
AATGGAGAGACTTCCGACACCCTCAATAATGTTGGATACCAAGGTCCTACCAAGATGACAAAAGAAGAGTTAAATGCCCTCAAGTCGACA
GGGGATGGGACCCTAGATGAGGAGGGGCCTGAGGGCCTGACCCAATTCTTGATGACAGAGGTGCGACGGCTGCGGGAAGCTCGCAAGAGC
CAGCTGCAGCGGGAGCAGCAACTGCAGGCCCGGGGCCGGGTGCTCGAGGAGGAGCGGGCAGGGCTGGAGCAGCGGCTGCGGGACCAGCAG
CAGGCTCAGGAGCGCTGTCAACGGCTGCGGGAGGACTGGGAGGCGGGCAGCCTGGAGCTGCTGCGGCTCAAGGATGAGAACTACATGATC
GCCATGCGCCTGGCACAGCTCAGTGAGGAGAAGAACTCGGCTGTACTTCGCAGCCGTGACCTGCAGCTGGCGGTGGATCAGCTCAAGCTC
AAAGTGAGTCGGCTGGAGGAAGAGTGTGCACTGCTTCGAAGGGCCAGGGGCCCGCCCCCTGGGGCAGAGGAGAAGGAGAAGGAGAAGGAG
AAGGAGAAGGAGCCAGACAATGTGGACCTTGTCTCTGAGCTGCGTGCTGAGAACCAGCGGCTGACGGCGTCACTGCGGGAGTTGCAGGAG
GGCCTGCAGCAGGAGGCGAGCCGGCCGGGGGCCCCGGGCTCCGAGCGCATCCTGCTGGACATCCTAGAGCATGACTGGCGGGAGGCGCAG
GACAGCAGGCAGGAGCTGTGCCAGAAGCTGCATGCCGTGCAGGGGGAGCTGCAGTGGGCCGAGGAGCTGCGCGACCAGTACCTGCAGGAG
ATGGAAGACCTGCGGCTCAAGCACCGCACGCTGCAGAAGGACTGTGACCTGTACAAGCACCGCATGGCCACTGTCCTGGCCCAACTGGAG
GAGATTGAGAAGGAGCGAGACCAGGCCATCCAGAGCCGTGACCGGATCCAGTTGCAGTACTCACAGAGCCTCATCGAGAAGGACCAGTAC
CGCAAGCAGGTGCGGGGCCTGGAGGCGGAGCGGGATGAGCTGCTGACAACGCTCACCAGCCTGGAGGGCACCAAGGCTCTGCTGGAGGTT
CAGCTGCAGCGGGCCCAGGGTGGCACCTGCCTCAAGGCCTGTGCCTCCTCCCATTCCCTGTGCTCCAACCTCAGCAGCACTTGGAGCCTG
AGCGAGTTCCCCTCCCCTCTGGGAGGCCCAGAAGCAACTGGGGAGGCAGCTGTCATGGGGGGACCTGAGCCTCACAACTCGGAGGAAGCC
ACAGACAGTGAAAAGGAGATCAATCGGCTCTCCATCCTGCCCTTCCCCCCCAGTGCCGGCTCCATCCTCCGCCGGCAGCGTGAGGAAGAC
CCCGCACCCCCTAAGAGATCCTTCAGCAGCATGTCAGACATCACAGGGAGTGTGACACTTAAGCCCTGGTCCCCTGGCCTCTCTTCGTCC
TCATCCTCTGACAGCGTGTGGCCTTTGGGAAAGCCGGAAGGCCTCCTGGCTCGGGGCTGTGGCCTGGACTTCCTCAACAGGTCTCTGGCT
ATTCGGGTGTCTGGCCGGAGCCCCCCAGGGGGCCCAGAGCCGCAGGACAAGGGACCAGATGGACTGTCGTTTTATGGGGACAGATGGTCT
GGGGCTGTGGTGCGCAGGGTGCTGTCTGGGCCTGGGTCCGCCAGGATGGAACCAAGAGAGCAAAGGGTGGAAGCTGCTGGTCTGGAGGGG
GCGTGCCTGGAAGCCGAGGCCCAGCAGAGAACCTTGCTCTGGAATCAGGGGTCCACACTCCCCTCCCTGATGGACTCGAAGGCCTGCCAG
TCCTTCCACGAGGCCCTAGAAGCCTGGGCAAAGGGACCAGGTGCCGAGCCCTTCTACATTCGTGCCAACCTCACCTTGCCTGAGAGGGCA
GATCCCCATGCCCTTTGCGTGAAAGCCCAAGAGATCCTTCGACTGGTGGACTCGGCATACAAGCGGAGGCAGGAATGGTTCTGCACCCGG
GTTGACCCCCTCACTCTGCGGGACCTGGACCGGGGCACCGTGCCCAATTATCAGAGAGCCCAGCAGCTCCTAGAAGTTCAGGAGAAATGC
CTGCCCTCCAGCCGGCACCGAGGCCCCCGCAGTAATCTGAAGAAGAGAGCCCTGGACCAGCTGCGGCTGGTGAGGCCCAAGCCCGTGGGG
GCGCCTGCAGGGGACTCCCCGGATCAGCTGCTGCTGGAGCCCTGTGCAGAGCCGGAGCGGAGCCTCAGACCCTACAGTTTGGTGCGGCCG
CTACTGGTGTCTGCCCTGCGGCCCGTGGTGCTGTTGCCTGAGTGCCTGGCGCCCCGGCTCATCCGTAACCTGCTAGACCTGCCCAGCTCC
CGGCTGGACTTCCAAGTGTGCCCAGCGGAAAGCCTCTCTGGGGAGGAACTGTGCCCATCCTCAGCGCCTGGAGCCCCCAAGGCTCAGCCT
GCCACCCCTGGGCTAGGCAGCAGGATCCGGGCCATCCAGGAGTCTGTTGGGAAGAAGCACTGCCTGCTGGAGCTGGGTGCTCGGGGTGTG
CGGGAGCTGGTGCAGAACGAGATCTACCCCATCGTCATCCACGTGGAGGTGACTGAGAAGAATGTCCGGGAAGTCAGGGGTCTGCTGGGC
CGGCCGGGCTGGCGGGACTCAGAGCTGCTGCGGCAGTGCCGTGGCTCAGAGCAGGTGCTCTGGGGGCTGCCCTGCTCCTGGGTGCAGGTG
CCCGCCCATGAGTGGGGACACGCAGAGGAGCTGGCCAAGGTGGTGCGCGGCCGCATCCTGCAGGAGCAGGCCCGCCTCGTGTGGGTGGAG
TGCGGCAGCAGCAGAGGCTGCCCCAGCAGCAGTGAGGCCTGAGGCTCATCTGATACCTGCACCTTCTCCCCAAGCCAGCGTGGACCCTGG
TGTCTATGGTGAAGCTGGGCCCTCCCACCCTGAGCCTTCCTAGACCCTTGGACTCTCAGATGCAGGGCCCTTGGCTCTGGCCTCTCACCC
CCAAGGCTGTCTCTGGCCCTGCCGAGCCTATGGGAGTCCCGGGACAGAGTGCCCACTCCCCTCTACTTGCTGCTCTGGGCCTCCCCACCT
TTCCTGGGGTCTCCACATTCCCACTAGTGGGTCTTATGTGTGTCTGTGTCTTCTCCTTAAACACTCGCCCTGGAGTCTGTTCTCACACCT
GTGCGCAGGTTTGCACACTCAAGTTCTCATGGGCAGGCTCAGGTCTGTCCCGCTGCCCTGGGCACGAGGTCTCCTGAGGACCTGGGCCTG
TTCTGCTCCTAGGAGACCTGAGCCCGTTACCGCGTGACTCCCACCATCCAGCTCGCGCTCCTCGTGGATTCAGCCATGCATGGACTGGGG
TGTTCCCTGGCCCATGGTCACCTGTGCCCCTCGTGTCTCCTCACATGGGTGTCTGTGGTTCTCTCCTGTGTAAATGTCACGCCCCACCCC
TGTTTCATGTGGGCACTAACACGTGTGCGTTCCTGGCGGGCACACTCAGGACCGTGCCTCACAGGGCCCACTCCCTGCCTATGCCTCCCT
CTTGGGGGGCCGAGGAGGGCGGCTGCTCTGTCATGAGAATGTACGGCCCGTGGATGATTAACGGGCCTTTTTCACTTAGAAGCTGCACAT

>50074_50074_4_LRRFIP1-CARD10_LRRFIP1_chr2_238668848_ENST00000392000_CARD10_chr22_37912305_ENST00000403299_length(amino acids)=1204AA_BP=296
MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEK
DFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ
LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLN
NVGYQGPTKMTKEELNALKSTGDGTLDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRL
REDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVD
LVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHR
TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGT
CLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFS
SMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLS
GPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKA
QEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQ
LLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRI
RAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAE

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Fusion Gene PPI Analysis for LRRFIP1-CARD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRFIP1-CARD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRFIP1-CARD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource