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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRFIP1-MLPH (FusionGDB2 ID:50080)

Fusion Gene Summary for LRRFIP1-MLPH

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRFIP1-MLPH
Fusion gene ID: 50080
HgeneTgene
Gene symbol

LRRFIP1

MLPH

Gene ID

9208

79083

Gene nameLRR binding FLII interacting protein 1melanophilin
SynonymsFLAP-1|FLAP1|FLIIAP1|GCF-2|GCF2|HUFI-1|TRIPSLAC2-A
Cytomap

2q37.3

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat flightless-interacting protein 1GC-binding factor 2LRR FLII-interacting protein 1NEDD8-conjugating enzymeTAR RNA-interacting proteinleucine rich repeat (in FLII) interacting protein 1melanophilinexophilin-3slp homolog lacking C2 domains asynaptotagmin-like protein 2a
Modification date2020031320200320
UniProtAcc

Q32MZ4

Q9BV36

Ensembl transtripts involved in fusion geneENST00000244815, ENST00000289175, 
ENST00000308482, ENST00000392000, 
ENST00000468950, 		ENST00000445024, 
ENST00000338530, ENST00000409373, 
ENST00000468178, ENST00000264605, 
ENST00000410032, 
Fusion gene scores* DoF score16 X 12 X 9=172812 X 13 X 9=1404
# samples 2014
** MAII scorelog2(20/1728*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1404*10)=-3.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRFIP1 [Title/Abstract] AND MLPH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRFIP1(238536383)-MLPH(238462208), # samples:1
LRRFIP1(238536383)-MLPH(238455249), # samples:1
LRRFIP1(238601164)-MLPH(238462209), # samples:1
LRRFIP1(238536383)-MLPH(238462209), # samples:1
Anticipated loss of major functional domain due to fusion event.LRRFIP1-MLPH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LRRFIP1-MLPH seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRRFIP1

GO:0000122

negative regulation of transcription by RNA polymerase II

14522076


check buttonFusion gene breakpoints across LRRFIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MLPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-IR-A3LA-01ALRRFIP1chr2

238536383

+MLPHchr2

238455249

+
ChimerDB4UCECTCGA-AJ-A3BD-01ALRRFIP1chr2

238536383

+MLPHchr2

238462209

+
ChimerDB4UCECTCGA-AJ-A3BD-01ALRRFIP1chr2

238601164

+MLPHchr2

238462209

+
ChimerDB4UCECTCGA-AJ-A3BDLRRFIP1chr2

238536383

+MLPHchr2

238462208

+


Top

Fusion Gene ORF analysis for LRRFIP1-MLPH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000244815ENST00000445024LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-3UTRENST00000289175ENST00000445024LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-3UTRENST00000308482ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
5CDS-3UTRENST00000308482ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
5CDS-3UTRENST00000308482ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
5CDS-3UTRENST00000392000ENST00000445024LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000244815ENST00000338530LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000244815ENST00000409373LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000244815ENST00000468178LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000289175ENST00000338530LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000289175ENST00000409373LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000289175ENST00000468178LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000308482ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
5CDS-intronENST00000308482ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
5CDS-intronENST00000308482ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
5CDS-intronENST00000308482ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
5CDS-intronENST00000308482ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
5CDS-intronENST00000308482ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
5CDS-intronENST00000308482ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
5CDS-intronENST00000308482ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
5CDS-intronENST00000308482ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
5CDS-intronENST00000392000ENST00000338530LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000392000ENST00000409373LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
5CDS-intronENST00000392000ENST00000468178LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
Frame-shiftENST00000244815ENST00000264605LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
Frame-shiftENST00000244815ENST00000410032LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
Frame-shiftENST00000289175ENST00000264605LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
Frame-shiftENST00000289175ENST00000410032LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
Frame-shiftENST00000308482ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
Frame-shiftENST00000308482ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
Frame-shiftENST00000308482ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
Frame-shiftENST00000308482ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
Frame-shiftENST00000392000ENST00000264605LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
Frame-shiftENST00000392000ENST00000410032LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
In-frameENST00000308482ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
In-frameENST00000308482ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000244815ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000244815ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000244815ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3CDSENST00000244815ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000244815ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000244815ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3CDSENST00000289175ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000289175ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000289175ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3CDSENST00000289175ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000289175ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000289175ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3CDSENST00000308482ENST00000264605LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-3CDSENST00000308482ENST00000410032LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-3CDSENST00000392000ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000392000ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000392000ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3CDSENST00000392000ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000392000ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000392000ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3CDSENST00000468950ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000468950ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000468950ENST00000264605LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-3CDSENST00000468950ENST00000264605LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3CDSENST00000468950ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3CDSENST00000468950ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3CDSENST00000468950ENST00000410032LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-3CDSENST00000468950ENST00000410032LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3UTRENST00000244815ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3UTRENST00000244815ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3UTRENST00000244815ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3UTRENST00000289175ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3UTRENST00000289175ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3UTRENST00000289175ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3UTRENST00000308482ENST00000445024LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-3UTRENST00000392000ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3UTRENST00000392000ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3UTRENST00000392000ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-3UTRENST00000468950ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-3UTRENST00000468950ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-3UTRENST00000468950ENST00000445024LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-3UTRENST00000468950ENST00000445024LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000244815ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000244815ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000244815ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000244815ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000244815ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000244815ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000244815ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000244815ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000244815ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000289175ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000289175ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000289175ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000289175ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000289175ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000289175ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000289175ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000289175ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000289175ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000308482ENST00000338530LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-intronENST00000308482ENST00000409373LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-intronENST00000308482ENST00000468178LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-intronENST00000392000ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000392000ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000392000ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000392000ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000392000ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000392000ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000392000ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000392000ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000392000ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000468950ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000468950ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000468950ENST00000338530LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-intronENST00000468950ENST00000338530LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000468950ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000468950ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000468950ENST00000409373LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-intronENST00000468950ENST00000409373LRRFIP1chr2

238536383

+MLPHchr2

238462208

+
intron-intronENST00000468950ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238455249

+
intron-intronENST00000468950ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462209

+
intron-intronENST00000468950ENST00000468178LRRFIP1chr2

238601164

+MLPHchr2

238462209

+
intron-intronENST00000468950ENST00000468178LRRFIP1chr2

238536383

+MLPHchr2

238462208

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LRRFIP1-MLPH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LRRFIP1chr2238601164+MLPHchr2238462208+0.051766320.94823366
LRRFIP1chr2238536383+MLPHchr2238462208+3.73E-050.9999627
LRRFIP1chr2238536383+MLPHchr2238462208+3.73E-050.9999627
LRRFIP1chr2238536383+MLPHchr2238455248+7.17E-080.9999999
LRRFIP1chr2238601164+MLPHchr2238462208+0.051766320.94823366
LRRFIP1chr2238536383+MLPHchr2238462208+3.73E-050.9999627
LRRFIP1chr2238536383+MLPHchr2238462208+3.73E-050.9999627
LRRFIP1chr2238536383+MLPHchr2238455248+7.17E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LRRFIP1-MLPH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:238536383/chr2:238462208)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRFIP1

Q32MZ4

MLPH

Q9BV36

FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.FUNCTION: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000244815+110128_2500785.0Coiled coilOntology_term=ECO:0000269
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000289175+18128_2500753.0Coiled coilOntology_term=ECO:0000269
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000308482+124128_25032641.0Coiled coilOntology_term=ECO:0000269
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000392000+111128_2500809.0Coiled coilOntology_term=ECO:0000269
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000244815+110567_5930785.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000289175+18567_5930753.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000308482+124567_59332641.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000392000+111567_5930809.0Compositional biasNote=Lys-rich
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000244815+110485_5840785.0RegionNote=DNA-binding
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000289175+18485_5840753.0RegionNote=DNA-binding
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000308482+124485_58432641.0RegionNote=DNA-binding
HgeneLRRFIP1chr2:238536383chr2:238455249ENST00000392000+111485_5840809.0RegionNote=DNA-binding
TgeneMLPHchr2:238536383chr2:238455249ENST000002646051116373_496513601.0Coiled coilOntology_term=ECO:0000255
TgeneMLPHchr2:238536383chr2:238455249ENST000003385301015373_496485573.0Coiled coilOntology_term=ECO:0000255
TgeneMLPHchr2:238536383chr2:238455249ENST00000409373813373_496393481.0Coiled coilOntology_term=ECO:0000255
TgeneMLPHchr2:238536383chr2:238455249ENST0000026460511164_124513601.0DomainRabBD
TgeneMLPHchr2:238536383chr2:238455249ENST0000033853010154_124485573.0DomainRabBD
TgeneMLPHchr2:238536383chr2:238455249ENST000004093738134_124393481.0DomainRabBD
TgeneMLPHchr2:238536383chr2:238455249ENST00000264605111664_107513601.0Zinc fingerNote=FYVE-type
TgeneMLPHchr2:238536383chr2:238455249ENST00000338530101564_107485573.0Zinc fingerNote=FYVE-type
TgeneMLPHchr2:238536383chr2:238455249ENST0000040937381364_107393481.0Zinc fingerNote=FYVE-type


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Fusion Gene Sequence for LRRFIP1-MLPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LRRFIP1-MLPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRFIP1-MLPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRFIP1-MLPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource