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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRFIP2-RAP1B (FusionGDB2 ID:50099)

Fusion Gene Summary for LRRFIP2-RAP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRFIP2-RAP1B
Fusion gene ID: 50099
HgeneTgene
Gene symbol

LRRFIP2

RAP1B

Gene ID

9209

5908

Gene nameLRR binding FLII interacting protein 2RAP1B, member of RAS oncogene family
SynonymsHUFI-2K-REV|RAL1B
Cytomap

3p22.2

12q15

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat flightless-interacting protein 2LRR FLII-interacting protein 2leucine rich repeat (in FLII) interacting protein 2ras-related protein Rap-1bGTP-binding protein smg p21BRAS-related protein RAP1BRas family small GTP binding protein RAP1Bsmall GTP binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336686, ENST00000354379, 
ENST00000396428, ENST00000421276, 
ENST00000421307, ENST00000440230, 
ENST00000490597, 		ENST00000450214, 
ENST00000463493, ENST00000378985, 
ENST00000539091, ENST00000540209, 
ENST00000543393, ENST00000541216, 
ENST00000542145, ENST00000543697, 
ENST00000250559, ENST00000341355, 
ENST00000393436, ENST00000537460, 
Fusion gene scores* DoF score15 X 15 X 8=180016 X 11 X 8=1408
# samples 1716
** MAII scorelog2(17/1800*10)=-3.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1408*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRRFIP2 [Title/Abstract] AND RAP1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRFIP2(37170553)-RAP1B(69047891), # samples:1
Anticipated loss of major functional domain due to fusion event.LRRFIP2-RAP1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LRRFIP2-RAP1B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAP1B

GO:0071320

cellular response to cAMP

21840392


check buttonFusion gene breakpoints across LRRFIP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAP1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-AF-3400-11ALRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+


Top

Fusion Gene ORF analysis for LRRFIP2-RAP1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000336686ENST00000450214LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000336686ENST00000463493LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000354379ENST00000450214LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000354379ENST00000463493LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000396428ENST00000450214LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000396428ENST00000463493LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000421276ENST00000450214LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000421276ENST00000463493LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000421307ENST00000450214LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000421307ENST00000463493LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000440230ENST00000450214LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-3UTRENST00000440230ENST00000463493LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000336686ENST00000378985LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000336686ENST00000539091LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000336686ENST00000540209LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000336686ENST00000543393LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000354379ENST00000378985LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000354379ENST00000539091LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000354379ENST00000540209LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000354379ENST00000543393LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000396428ENST00000378985LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000396428ENST00000539091LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000396428ENST00000540209LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000396428ENST00000543393LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421276ENST00000378985LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421276ENST00000539091LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421276ENST00000540209LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421276ENST00000543393LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421307ENST00000378985LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421307ENST00000539091LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421307ENST00000540209LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000421307ENST00000543393LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000440230ENST00000378985LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000440230ENST00000539091LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000440230ENST00000540209LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-5UTRENST00000440230ENST00000543393LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000336686ENST00000541216LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000336686ENST00000542145LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000336686ENST00000543697LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000354379ENST00000541216LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000354379ENST00000542145LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000354379ENST00000543697LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000396428ENST00000541216LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000396428ENST00000542145LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000396428ENST00000543697LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000421276ENST00000541216LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000421276ENST00000542145LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000421276ENST00000543697LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000421307ENST00000541216LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000421307ENST00000542145LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000421307ENST00000543697LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000440230ENST00000541216LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000440230ENST00000542145LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
5CDS-intronENST00000440230ENST00000543697LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000354379ENST00000250559LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000354379ENST00000341355LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000354379ENST00000393436LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000354379ENST00000537460LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000396428ENST00000250559LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000396428ENST00000341355LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000396428ENST00000393436LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000396428ENST00000537460LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421276ENST00000250559LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421276ENST00000341355LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421276ENST00000393436LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421276ENST00000537460LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421307ENST00000250559LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421307ENST00000341355LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421307ENST00000393436LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
Frame-shiftENST00000421307ENST00000537460LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000336686ENST00000250559LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000336686ENST00000341355LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000336686ENST00000393436LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000336686ENST00000537460LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000440230ENST00000250559LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000440230ENST00000341355LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000440230ENST00000393436LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
In-frameENST00000440230ENST00000537460LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-3CDSENST00000490597ENST00000250559LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-3CDSENST00000490597ENST00000341355LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-3CDSENST00000490597ENST00000393436LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-3CDSENST00000490597ENST00000537460LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-3UTRENST00000490597ENST00000450214LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-3UTRENST00000490597ENST00000463493LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-5UTRENST00000490597ENST00000378985LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-5UTRENST00000490597ENST00000539091LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-5UTRENST00000490597ENST00000540209LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-5UTRENST00000490597ENST00000543393LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-intronENST00000490597ENST00000541216LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-intronENST00000490597ENST00000542145LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+
intron-intronENST00000490597ENST00000543697LRRFIP2chr3

37170553

-RAP1Bchr12

69047891

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336686LRRFIP2chr337170553-ENST00000250559RAP1Bchr1269047891+197325881629182
ENST00000336686LRRFIP2chr337170553-ENST00000393436RAP1Bchr1269047891+190325881629182
ENST00000336686LRRFIP2chr337170553-ENST00000341355RAP1Bchr1269047891+63425881629182
ENST00000336686LRRFIP2chr337170553-ENST00000537460RAP1Bchr1269047891+78225881629182
ENST00000440230LRRFIP2chr337170553-ENST00000250559RAP1Bchr1269047891+25057906131161182
ENST00000440230LRRFIP2chr337170553-ENST00000393436RAP1Bchr1269047891+24357906131161182
ENST00000440230LRRFIP2chr337170553-ENST00000341355RAP1Bchr1269047891+11667906131161182
ENST00000440230LRRFIP2chr337170553-ENST00000537460RAP1Bchr1269047891+13147906131161182

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336686ENST00000250559LRRFIP2chr337170553-RAP1Bchr1269047891+0.0009971990.9990029
ENST00000336686ENST00000393436LRRFIP2chr337170553-RAP1Bchr1269047891+0.000841970.999158
ENST00000336686ENST00000341355LRRFIP2chr337170553-RAP1Bchr1269047891+0.0026981850.9973018
ENST00000336686ENST00000537460LRRFIP2chr337170553-RAP1Bchr1269047891+0.0019297370.9980703
ENST00000440230ENST00000250559LRRFIP2chr337170553-RAP1Bchr1269047891+0.0012808920.9987191
ENST00000440230ENST00000393436LRRFIP2chr337170553-RAP1Bchr1269047891+0.0013398320.9986602
ENST00000440230ENST00000341355LRRFIP2chr337170553-RAP1Bchr1269047891+0.0048191060.99518096
ENST00000440230ENST00000537460LRRFIP2chr337170553-RAP1Bchr1269047891+0.0036998240.99630016

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Fusion Genomic Features for LRRFIP2-RAP1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LRRFIP2chr337170553-RAP1Bchr1269047891+1.08E-070.9999999
LRRFIP2chr337170553-RAP1Bchr1269047891+1.08E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LRRFIP2-RAP1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:37170553/chr12:69047891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000336686-32822_4959722.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000354379-41422_4959401.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421276-41522_4959425.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421307-42922_4959722.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000440230-41522_4959425.0Coiled coilOntology_term=ECO:0000255
TgeneRAP1Bchr3:37170553chr12:69047891ENST000004502141632_4019379.3333333333333MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005390911632_4019224.33333333333334MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005421450732_400258.0MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000025055938116_11961554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000025055938147_14961554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000034135537116_11961185.0Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000034135537147_14961185.0Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000039343638116_11961534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000039343638147_14961534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000045021416116_11919379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000045021416147_14919379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000004502141657_6119379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000053746049116_11961180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000053746049147_14961180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000053909116116_11919224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000053909116147_14919224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005390911657_6119224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000054020927116_11942323.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000054020927147_14942323.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005402092757_6142323.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005421450710_180258.0Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000054214507116_1190258.0Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST0000054214507147_1490258.0Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005421450757_610258.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000336686-328349_52459722.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000336686-328566_71459722.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000354379-414349_52459401.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000354379-414566_71459401.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421276-415349_52459425.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421276-415566_71459425.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421307-429349_52459722.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421307-429566_71459722.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000440230-415349_52459425.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000440230-415566_71459425.0Coiled coilOntology_term=ECO:0000255
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000336686-328118_34259722.0Compositional biasNote=Ser-rich
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000354379-414118_34259401.0Compositional biasNote=Ser-rich
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421276-415118_34259425.0Compositional biasNote=Ser-rich
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421307-429118_34259722.0Compositional biasNote=Ser-rich
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000440230-415118_34259425.0Compositional biasNote=Ser-rich
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000336686-3281_37059722.0RegionNote=DVL3-binding
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000354379-4141_37059401.0RegionNote=DVL3-binding
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421276-4151_37059425.0RegionNote=DVL3-binding
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000421307-4291_37059722.0RegionNote=DVL3-binding
HgeneLRRFIP2chr3:37170553chr12:69047891ENST00000440230-4151_37059425.0RegionNote=DVL3-binding
TgeneRAP1Bchr3:37170553chr12:69047891ENST000002505593832_4061554.3333333333334MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003413553732_4061185.0MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003934363832_4061534.3333333333334MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005374604932_4061180.33333333333334MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005402092732_4042323.3333333333333MotifEffector region
TgeneRAP1Bchr3:37170553chr12:69047891ENST000002505593810_1861554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000002505593857_6161554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003413553710_1861185.0Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003413553757_6161185.0Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003934363810_1861534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003934363857_6161534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000004502141610_1819379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005374604910_1861180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005374604957_6161180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005390911610_1819224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005402092710_1842323.3333333333333Nucleotide bindingGTP


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Fusion Gene Sequence for LRRFIP2-RAP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50099_50099_1_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000250559_length(transcript)=1973nt_BP=258nt
TGGAAAGGAGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACT
CCTGCTTCTGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCA
AGGCTGGCAGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACA
GCAATGAGGGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGAC
CTGAGAGAACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTT
GTAGGGAAGGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAAT
GAGATCTTTTATGACCTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCATGTCAGCTGCTTTAA
TATACTAAATGCATTGTAGCTCTGAGCCAGGTCTGAAGAACTGTTGCCCAATTCAACAGTGCCAGCATTCCAACTTTGTTAAACCTACCA
ACATCTTAAATGGACTTTCCTGTGGTGGTACCCTTTAAGAGGCGGATGAAAGCTACTATATCAGTTTGCACATTCTAATCACTTTCCAGT
ATCACAAGAGAGATTTTTACTTATATAATAGTCCTAGAGTTTGCAGCTGGTAAAACCAGAGGCTACATCCAGTATTACTGCTAAGAGACA
TTCTTCATCCACCAATGTTGTACATGTATGAAAATGGTGTACTGTATACTTTAACATGCCCCATACTTTGTATTGGAGAGTACAATAATG
TAAATCCTAAAAGCACCACTATTTTAGCATAATAAAAGAAAGTCCAAAGAGCTCCTATATAGACTACTCCAGATAACTTCGCTTCTTTGA
TACTTGTAGCTTATTGTAATTTTTTTTAAGAAATTCAAGGTCATTATTATTGTACAAAATAAGCGCTTTGATTAACACAGCTATATAGTT
TTTTTAATTTTTAAAAAACCTGTGGAGACGGTGATCTTGTCTTTAAAACATGATAGTCCTTTCAGTATAATGTCTTAGATTAAAGACGTT
GCCTTTAATATCTGTTGGGAAGGAAATGTCCAGACTTTTCAAATCTCTTATTATATGTTTCCTTTTTTTGTTTACATAGGGAACAATGTT
TATAGTCGTGTGTACAGTGGGGGTCTACAACAAGAAGTGTATATTTTCAAACAATTTTTTAATGATTTAACAATTTTTGTAAATCATTTT
CAGGCTTCTGCAGCTGTAGATTCTCACTGTGAATCCCTTGCTTGCTCATGCATAAGTGTATTTGCAATACCAAATATACAGGTTTAGTAT
TTTTGCCTGTTAGTGATTGTTTCACATGTGTAACGTTTTGGTTGAGATGTTAAATGGTGGACGAGTACTGTGGATGTGAATGTGGGAAGT
AATTTTAATCATATGTAATTGGTCACAAGGCCTAATTTGCAGTAACTATTGCTGTTTTATTTAACAATGCCTTGTTGCTTTGTATGCATT
AATGTTTGGATGTAAAGATTGTGTGTCTATCCAACAGGGAGCCACAGTATTTAAATTGACCAACCTAATGTTACAACTACTTTGAGGTGG
CCAAATGTAAACTAAAAGCCTTAATTAAAGTGGTGCAATTTTGTATAACTTAGCATCAGTAGTTCAATAAATTTGGATTGCCATGCAAGG

>50099_50099_1_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000250559_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

--------------------------------------------------------------
>50099_50099_2_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000341355_length(transcript)=634nt_BP=258nt
TGGAAAGGAGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACT
CCTGCTTCTGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCA
AGGCTGGCAGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACA
GCAATGAGGGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGAC
CTGAGAGAACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTT
GTAGGGAAGGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAAT
GAGATCTTTTATGACCTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCATGTCAGCTGCTTTAA

>50099_50099_2_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000341355_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

--------------------------------------------------------------
>50099_50099_3_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000393436_length(transcript)=1903nt_BP=258nt
TGGAAAGGAGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACT
CCTGCTTCTGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCA
AGGCTGGCAGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACA
GCAATGAGGGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGAC
CTGAGAGAACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTT
GTAGGGAAGGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAAT
GAGATCTTTTATGACCTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCATGTCAGCTGCTTTAA
TATACTAAATGCATTGTAGCTCTGAGCCAGGTCTGAAGAACTGTTGCCCAATTCAACAGTGCCAGCATTCCAACTTTGTTAAACCTACCA
ACATCTTAAATGGACTTTCCTGTGGTGGTACCCTTTAAGAGGCGGATGAAAGCTACTATATCAGTTTGCACATTCTAATCACTTTCCAGT
ATCACAAGAGAGATTTTTACTTATATAATAGTCCTAGAGTTTGCAGCTGGTAAAACCAGAGGCTACATCCAGTATTACTGCTAAGAGACA
TTCTTCATCCACCAATGTTGTACATGTATGAAAATGGTGTACTGTATACTTTAACATGCCCCATACTTTGTATTGGAGAGTACAATAATG
TAAATCCTAAAAGCACCACTATTTTAGCATAATAAAAGAAAGTCCAAAGAGCTCCTATATAGACTACTCCAGATAACTTCGCTTCTTTGA
TACTTGTAGCTTATTGTAATTTTTTTTAAGAAATTCAAGGTCATTATTATTGTACAAAATAAGCGCTTTGATTAACACAGCTATATAGTT
TTTTTAATTTTTAAAAAACCTGTGGAGACGGTGATCTTGTCTTTAAAACATGATAGTCCTTTCAGTATAATGTCTTAGATTAAAGACGTT
GCCTTTAATATCTGTTGGGAAGGAAATGTCCAGACTTTTCAAATCTCTTATTATATGTTTCCTTTTTTTGTTTACATAGGGAACAATGTT
TATAGTCGTGTGTACAGTGGGGGTCTACAACAAGAAGTGTATATTTTCAAACAATTTTTTAATGATTTAACAATTTTTGTAAATCATTTT
CAGGCTTCTGCAGCTGTAGATTCTCACTGTGAATCCCTTGCTTGCTCATGCATAAGTGTATTTGCAATACCAAATATACAGGTTTAGTAT
TTTTGCCTGTTAGTGATTGTTTCACATGTGTAACGTTTTGGTTGAGATGTTAAATGGTGGACGAGTACTGTGGATGTGAATGTGGGAAGT
AATTTTAATCATATGTAATTGGTCACAAGGCCTAATTTGCAGTAACTATTGCTGTTTTATTTAACAATGCCTTGTTGCTTTGTATGCATT
AATGTTTGGATGTAAAGATTGTGTGTCTATCCAACAGGGAGCCACAGTATTTAAATTGACCAACCTAATGTTACAACTACTTTGAGGTGG
CCAAATGTAAACTAAAAGCCTTAATTAAAGTGGTGCAATTTTGTATAACTTAGCATCAGTAGTTCAATAAATTTGGATTGCCATGCAAGG

>50099_50099_3_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000393436_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

--------------------------------------------------------------
>50099_50099_4_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000537460_length(transcript)=782nt_BP=258nt
TGGAAAGGAGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACT
CCTGCTTCTGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCA
AGGCTGGCAGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACA
GCAATGAGGGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGAC
CTGAGAGAACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTT
GTAGGGAAGGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAAT
GAGATCTTTTATGACCTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCATGTCAGCTGCTTTAA
TATACTAAATGCATTGTAGCTCTGAGCCAGGTCTGAAGAACTGTTGCCCAATTCAACAGTGCCAGCATTCCAACTTTGTTAAACCTACCA

>50099_50099_4_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000336686_RAP1B_chr12_69047891_ENST00000537460_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

--------------------------------------------------------------
>50099_50099_5_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000250559_length(transcript)=2505nt_BP=790nt
GGCTGCGGCTCCTCCCGGGGCCGGTTCCCGCTGTCTCAGCCGCGGCGCAGAGGGCACATCGGCCTGACCGACTAGCCGGCTGCCAGTGCC
GGGAGCCGCCGCGTCCATCCCCGCCCGCCTGGCCGGGGACCCAGGACTGAGTCGTCCAGCTGCGCCCCTCGCCCATAGCCCCAGCGGGCG
CCGGGCGGGCGAGCAGCTCTTCGGCCCTTCCCGGACAGCGACGCAGTCGCAGCGCGCGCCCTAACACAGGTAAGGGCCGCTCCTCCCGCC
AGCCCGGTGGGAGCAGGGAGCGGGGAGTTGGGAACCTTTTTCCCGGCCTCCGCAGTCCCGTGGGATCCGCGCCGCCTCCGACCTCGGCTA
GGGGGCCGGGCTTCCCTGGGGACTGGCCGGCCCGCGGCGGGCTCCCGGGCTGGGGTCGCCCCCTGCCTGCGGCGTTCTCAGACATCCCGT
CTGATTTCTAACGCTCACCCTTCCACCGCGCTGGGGAAAAGATGTGGGAAGATAAATGAAGGGGTCTAGATGTAAATGTCAGTGGAAAGG
AGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACTCCTGCTTC
TGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCAAGGCTGGC
AGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACAGCAATGAG
GGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGACCTGAGAGA
ACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTTGTAGGGAA
GGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAATGAGATCTT
TTATGACCTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCATGTCAGCTGCTTTAATATACTAA
ATGCATTGTAGCTCTGAGCCAGGTCTGAAGAACTGTTGCCCAATTCAACAGTGCCAGCATTCCAACTTTGTTAAACCTACCAACATCTTA
AATGGACTTTCCTGTGGTGGTACCCTTTAAGAGGCGGATGAAAGCTACTATATCAGTTTGCACATTCTAATCACTTTCCAGTATCACAAG
AGAGATTTTTACTTATATAATAGTCCTAGAGTTTGCAGCTGGTAAAACCAGAGGCTACATCCAGTATTACTGCTAAGAGACATTCTTCAT
CCACCAATGTTGTACATGTATGAAAATGGTGTACTGTATACTTTAACATGCCCCATACTTTGTATTGGAGAGTACAATAATGTAAATCCT
AAAAGCACCACTATTTTAGCATAATAAAAGAAAGTCCAAAGAGCTCCTATATAGACTACTCCAGATAACTTCGCTTCTTTGATACTTGTA
GCTTATTGTAATTTTTTTTAAGAAATTCAAGGTCATTATTATTGTACAAAATAAGCGCTTTGATTAACACAGCTATATAGTTTTTTTAAT
TTTTAAAAAACCTGTGGAGACGGTGATCTTGTCTTTAAAACATGATAGTCCTTTCAGTATAATGTCTTAGATTAAAGACGTTGCCTTTAA
TATCTGTTGGGAAGGAAATGTCCAGACTTTTCAAATCTCTTATTATATGTTTCCTTTTTTTGTTTACATAGGGAACAATGTTTATAGTCG
TGTGTACAGTGGGGGTCTACAACAAGAAGTGTATATTTTCAAACAATTTTTTAATGATTTAACAATTTTTGTAAATCATTTTCAGGCTTC
TGCAGCTGTAGATTCTCACTGTGAATCCCTTGCTTGCTCATGCATAAGTGTATTTGCAATACCAAATATACAGGTTTAGTATTTTTGCCT
GTTAGTGATTGTTTCACATGTGTAACGTTTTGGTTGAGATGTTAAATGGTGGACGAGTACTGTGGATGTGAATGTGGGAAGTAATTTTAA
TCATATGTAATTGGTCACAAGGCCTAATTTGCAGTAACTATTGCTGTTTTATTTAACAATGCCTTGTTGCTTTGTATGCATTAATGTTTG
GATGTAAAGATTGTGTGTCTATCCAACAGGGAGCCACAGTATTTAAATTGACCAACCTAATGTTACAACTACTTTGAGGTGGCCAAATGT
AAACTAAAAGCCTTAATTAAAGTGGTGCAATTTTGTATAACTTAGCATCAGTAGTTCAATAAATTTGGATTGCCATGCAAGGGCTTGCAT

>50099_50099_5_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000250559_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

--------------------------------------------------------------
>50099_50099_6_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000341355_length(transcript)=1166nt_BP=790nt
GGCTGCGGCTCCTCCCGGGGCCGGTTCCCGCTGTCTCAGCCGCGGCGCAGAGGGCACATCGGCCTGACCGACTAGCCGGCTGCCAGTGCC
GGGAGCCGCCGCGTCCATCCCCGCCCGCCTGGCCGGGGACCCAGGACTGAGTCGTCCAGCTGCGCCCCTCGCCCATAGCCCCAGCGGGCG
CCGGGCGGGCGAGCAGCTCTTCGGCCCTTCCCGGACAGCGACGCAGTCGCAGCGCGCGCCCTAACACAGGTAAGGGCCGCTCCTCCCGCC
AGCCCGGTGGGAGCAGGGAGCGGGGAGTTGGGAACCTTTTTCCCGGCCTCCGCAGTCCCGTGGGATCCGCGCCGCCTCCGACCTCGGCTA
GGGGGCCGGGCTTCCCTGGGGACTGGCCGGCCCGCGGCGGGCTCCCGGGCTGGGGTCGCCCCCTGCCTGCGGCGTTCTCAGACATCCCGT
CTGATTTCTAACGCTCACCCTTCCACCGCGCTGGGGAAAAGATGTGGGAAGATAAATGAAGGGGTCTAGATGTAAATGTCAGTGGAAAGG
AGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACTCCTGCTTC
TGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCAAGGCTGGC
AGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACAGCAATGAG
GGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGACCTGAGAGA
ACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTTGTAGGGAA
GGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAATGAGATCTT

>50099_50099_6_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000341355_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

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>50099_50099_7_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000393436_length(transcript)=2435nt_BP=790nt
GGCTGCGGCTCCTCCCGGGGCCGGTTCCCGCTGTCTCAGCCGCGGCGCAGAGGGCACATCGGCCTGACCGACTAGCCGGCTGCCAGTGCC
GGGAGCCGCCGCGTCCATCCCCGCCCGCCTGGCCGGGGACCCAGGACTGAGTCGTCCAGCTGCGCCCCTCGCCCATAGCCCCAGCGGGCG
CCGGGCGGGCGAGCAGCTCTTCGGCCCTTCCCGGACAGCGACGCAGTCGCAGCGCGCGCCCTAACACAGGTAAGGGCCGCTCCTCCCGCC
AGCCCGGTGGGAGCAGGGAGCGGGGAGTTGGGAACCTTTTTCCCGGCCTCCGCAGTCCCGTGGGATCCGCGCCGCCTCCGACCTCGGCTA
GGGGGCCGGGCTTCCCTGGGGACTGGCCGGCCCGCGGCGGGCTCCCGGGCTGGGGTCGCCCCCTGCCTGCGGCGTTCTCAGACATCCCGT
CTGATTTCTAACGCTCACCCTTCCACCGCGCTGGGGAAAAGATGTGGGAAGATAAATGAAGGGGTCTAGATGTAAATGTCAGTGGAAAGG
AGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACTCCTGCTTC
TGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCAAGGCTGGC
AGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACAGCAATGAG
GGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGACCTGAGAGA
ACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTTGTAGGGAA
GGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAATGAGATCTT
TTATGACCTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCATGTCAGCTGCTTTAATATACTAA
ATGCATTGTAGCTCTGAGCCAGGTCTGAAGAACTGTTGCCCAATTCAACAGTGCCAGCATTCCAACTTTGTTAAACCTACCAACATCTTA
AATGGACTTTCCTGTGGTGGTACCCTTTAAGAGGCGGATGAAAGCTACTATATCAGTTTGCACATTCTAATCACTTTCCAGTATCACAAG
AGAGATTTTTACTTATATAATAGTCCTAGAGTTTGCAGCTGGTAAAACCAGAGGCTACATCCAGTATTACTGCTAAGAGACATTCTTCAT
CCACCAATGTTGTACATGTATGAAAATGGTGTACTGTATACTTTAACATGCCCCATACTTTGTATTGGAGAGTACAATAATGTAAATCCT
AAAAGCACCACTATTTTAGCATAATAAAAGAAAGTCCAAAGAGCTCCTATATAGACTACTCCAGATAACTTCGCTTCTTTGATACTTGTA
GCTTATTGTAATTTTTTTTAAGAAATTCAAGGTCATTATTATTGTACAAAATAAGCGCTTTGATTAACACAGCTATATAGTTTTTTTAAT
TTTTAAAAAACCTGTGGAGACGGTGATCTTGTCTTTAAAACATGATAGTCCTTTCAGTATAATGTCTTAGATTAAAGACGTTGCCTTTAA
TATCTGTTGGGAAGGAAATGTCCAGACTTTTCAAATCTCTTATTATATGTTTCCTTTTTTTGTTTACATAGGGAACAATGTTTATAGTCG
TGTGTACAGTGGGGGTCTACAACAAGAAGTGTATATTTTCAAACAATTTTTTAATGATTTAACAATTTTTGTAAATCATTTTCAGGCTTC
TGCAGCTGTAGATTCTCACTGTGAATCCCTTGCTTGCTCATGCATAAGTGTATTTGCAATACCAAATATACAGGTTTAGTATTTTTGCCT
GTTAGTGATTGTTTCACATGTGTAACGTTTTGGTTGAGATGTTAAATGGTGGACGAGTACTGTGGATGTGAATGTGGGAAGTAATTTTAA
TCATATGTAATTGGTCACAAGGCCTAATTTGCAGTAACTATTGCTGTTTTATTTAACAATGCCTTGTTGCTTTGTATGCATTAATGTTTG
GATGTAAAGATTGTGTGTCTATCCAACAGGGAGCCACAGTATTTAAATTGACCAACCTAATGTTACAACTACTTTGAGGTGGCCAAATGT
AAACTAAAAGCCTTAATTAAAGTGGTGCAATTTTGTATAACTTAGCATCAGTAGTTCAATAAATTTGGATTGCCATGCAAGGGCTTGCAT

>50099_50099_7_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000393436_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

--------------------------------------------------------------
>50099_50099_8_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000537460_length(transcript)=1314nt_BP=790nt
GGCTGCGGCTCCTCCCGGGGCCGGTTCCCGCTGTCTCAGCCGCGGCGCAGAGGGCACATCGGCCTGACCGACTAGCCGGCTGCCAGTGCC
GGGAGCCGCCGCGTCCATCCCCGCCCGCCTGGCCGGGGACCCAGGACTGAGTCGTCCAGCTGCGCCCCTCGCCCATAGCCCCAGCGGGCG
CCGGGCGGGCGAGCAGCTCTTCGGCCCTTCCCGGACAGCGACGCAGTCGCAGCGCGCGCCCTAACACAGGTAAGGGCCGCTCCTCCCGCC
AGCCCGGTGGGAGCAGGGAGCGGGGAGTTGGGAACCTTTTTCCCGGCCTCCGCAGTCCCGTGGGATCCGCGCCGCCTCCGACCTCGGCTA
GGGGGCCGGGCTTCCCTGGGGACTGGCCGGCCCGCGGCGGGCTCCCGGGCTGGGGTCGCCCCCTGCCTGCGGCGTTCTCAGACATCCCGT
CTGATTTCTAACGCTCACCCTTCCACCGCGCTGGGGAAAAGATGTGGGAAGATAAATGAAGGGGTCTAGATGTAAATGTCAGTGGAAAGG
AGAGCTACCATCACTAAGGGCTGAAAACACAGTTAAATCACTTTCAAAGTTAAAAGACTATTAAGAACACAAGATGGGGACTCCTGCTTC
TGGAAGGAAAAGAACACCTGTGAAAGACCGATTTTCTGCAGAAGATGAAGCTTTGAGTAACATTGCCAGAGAGGCAGAGGCAAGGCTGGC
AGCAAAACGGGCTGCCCGGGCAGAAGCAAGAGATATACGCATGAGAGAACTGGAACGACAACAAAAAGAGGAGCAATTTACAGCAATGAG
GGATTTATACATGAAAAATGGACAAGGATTTGCATTAGTTTATTCCATCACAGCACAGTCCACATTTAACGATTTACAAGACCTGAGAGA
ACAGATTCTTCGAGTTAAAGACACTGATGATGTTCCAATGATTCTTGTTGGTAATAAGTGTGACTTGGAAGATGAAAGAGTTGTAGGGAA
GGAACAAGGTCAAAATCTAGCAAGACAATGGAACAACTGTGCATTCTTAGAATCTTCTGCAAAATCAAAAATAAATGTTAATGAGATCTT
TTATGACCTAGTGCGGCAAATTAACAGAAAAACTCCAGTGCCTGGGAAGGCTCGCAAAAAGTCATCATGTCAGCTGCTTTAATATACTAA
ATGCATTGTAGCTCTGAGCCAGGTCTGAAGAACTGTTGCCCAATTCAACAGTGCCAGCATTCCAACTTTGTTAAACCTACCAACATCTTA

>50099_50099_8_LRRFIP2-RAP1B_LRRFIP2_chr3_37170553_ENST00000440230_RAP1B_chr12_69047891_ENST00000537460_length(amino acids)=182AA_BP=59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEEQFTAMRDLYMKNGQGFALVYSITAQSTFND
LQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQ

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Fusion Gene PPI Analysis for LRRFIP2-RAP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRAP1Bchr3:37170553chr12:69047891ENST000004502141625_6719.0379.3333333333333KRIT1
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005390911625_6719.0224.33333333333334KRIT1
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005421450725_670258.0KRIT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRAP1Bchr3:37170553chr12:69047891ENST000002505593825_6761.0554.3333333333334KRIT1
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003413553725_6761.0185.0KRIT1
TgeneRAP1Bchr3:37170553chr12:69047891ENST000003934363825_6761.0534.3333333333334KRIT1
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005374604925_6761.0180.33333333333334KRIT1
TgeneRAP1Bchr3:37170553chr12:69047891ENST000005402092725_6742.0323.3333333333333KRIT1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRFIP2-RAP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRFIP2-RAP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource