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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ANXA11-MBP (FusionGDB2 ID:5010)

Fusion Gene Summary for ANXA11-MBP

Fusion gene summary

Fusion gene information	Fusion gene name: ANXA11-MBP
	Fusion gene ID: 5010
		Hgene	Tgene
	Gene symbol	ANXA11	MBP
	Gene ID	311	5553
	Gene name	annexin A11	proteoglycan 2, pro eosinophil major basic protein
	Synonyms	ALS23\|ANX11\|CAP-50\|CAP50	BMPG\|MBP\|MBP1\|proMBP
	Cytomap	10q22.3	11q12.1
	Type of gene	protein-coding	protein-coding
	Description	annexin A1156 kDa autoantigenannexin XIannexin-11calcyclin-associated annexin 50epididymis secretory sperm binding protein	bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
	Modification date	20200313	20200313
	UniProtAcc	P50995	P02686
	Ensembl transtripts involved in fusion gene	ENST00000265447, ENST00000360615, ENST00000372231, ENST00000422982, ENST00000438331, ENST00000535999, ENST00000537102, ENST00000463657,	ENST00000354542, ENST00000355994, ENST00000359645, ENST00000382582, ENST00000397860, ENST00000397863, ENST00000397865, ENST00000397866, ENST00000397869, ENST00000397875, ENST00000487778, ENST00000526111, ENST00000527041, ENST00000528160, ENST00000578193, ENST00000579129, ENST00000580402,
Fusion gene scores	* DoF score	11 X 8 X 4=352	32 X 27 X 4=3456
	# samples	11	32
	** MAII score	log2(11/352*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(32/3456*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ANXA11 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANXA11(81932561)-MBP(74746752), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ANXA11	GO:0051592	response to calcium ion	9188810\|12601007

Fusion gene breakpoints across ANXA11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BM146268	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-

Top

Fusion Gene ORF analysis for ANXA11-MBP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265447	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000265447	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000360615	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000372231	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000422982	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000438331	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5CDS-intron	ENST00000535999	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
5UTR-intron	ENST00000537102	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000354542	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000355994	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000359645	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000382582	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000397860	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000397863	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000397865	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000397866	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000397869	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000397875	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000487778	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000526111	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000527041	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000528160	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000578193	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000579129	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-
intron-intron	ENST00000463657	ENST00000580402	ANXA11	chr10	81932561	-	MBP	chr18	74746752	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ANXA11-MBP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANXA11-MBP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:81932561/:74746752)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANXA11 P50995	MBP P02686
FUNCTION: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. {ECO:0000250, ECO:0000269\|PubMed:15197175}.	FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269\|PubMed:8544862}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ANXA11-MBP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANXA11-MBP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ANXA11-MBP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ANXA11-MBP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source