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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRRK1-ADAMTS17 (FusionGDB2 ID:50105)

Fusion Gene Summary for LRRK1-ADAMTS17

check button Fusion gene summary
Fusion gene informationFusion gene name: LRRK1-ADAMTS17
Fusion gene ID: 50105
HgeneTgene
Gene symbol

LRRK1

ADAMTS17

Gene ID

79705

170691

Gene nameleucine rich repeat kinase 1ADAM metallopeptidase with thrombospondin type 1 motif 17
SynonymsRIPK6|Roco1WMS4
Cytomap

15q26.3

15q26.3

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat serine/threonine-protein kinase 1A disintegrin and metalloproteinase with thrombospondin motifs 17a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17
Modification date2020031320200313
UniProtAcc

Q38SD2

Q8TE56

Ensembl transtripts involved in fusion geneENST00000284395, ENST00000388948, 
ENST00000532029, ENST00000532145, 
ENST00000559976, ENST00000268070, 
Fusion gene scores* DoF score5 X 4 X 3=602 X 2 X 2=8
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: LRRK1 [Title/Abstract] AND ADAMTS17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRRK1(101529603)-ADAMTS17(100591936), # samples:3
Anticipated loss of major functional domain due to fusion event.LRRK1-ADAMTS17 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LRRK1-ADAMTS17 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
LRRK1-ADAMTS17 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRRK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAMTS17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A4RW-01ALRRK1chr15

101529603

-ADAMTS17chr15

100591936

-
ChimerDB4BRCATCGA-A2-A4RW-01ALRRK1chr15

101529603

+ADAMTS17chr15

100591936

-


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Fusion Gene ORF analysis for LRRK1-ADAMTS17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000284395ENST00000559976LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-
5CDS-intronENST00000388948ENST00000559976LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-
5CDS-intronENST00000532029ENST00000559976LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-
Frame-shiftENST00000532029ENST00000268070LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-
In-frameENST00000284395ENST00000268070LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-
In-frameENST00000388948ENST00000268070LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-
intron-3CDSENST00000532145ENST00000268070LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-
intron-intronENST00000532145ENST00000559976LRRK1chr15

101529603

+ADAMTS17chr15

100591936

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000388948LRRK1chr15101529603+ENST00000268070ADAMTS17chr15100591936-492711213442113589
ENST00000284395LRRK1chr15101529603+ENST00000268070ADAMTS17chr15100591936-495911533042145613

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000388948ENST00000268070LRRK1chr15101529603+ADAMTS17chr15100591936-0.0162850450.983715
ENST00000284395ENST00000268070LRRK1chr15101529603+ADAMTS17chr15100591936-0.0135938010.98640615

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Fusion Genomic Features for LRRK1-ADAMTS17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LRRK1-ADAMTS17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:101529603/chr15:100591936)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRRK1

Q38SD2

ADAMTS17

Q8TE56


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634119_1482542016.0RepeatNote=ANK 2
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634152_1822542016.0RepeatNote=ANK 3
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634193_2222542016.0RepeatNote=ANK 4
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+63486_1162542016.0RepeatNote=ANK 1
TgeneADAMTS17chr15:101529603chr15:100591936ENST0000026807015221045_10847651096.0DomainPLAC
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522800_8607651096.0DomainTSP type-1 2
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522861_9227651096.0DomainTSP type-1 3
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522925_9687651096.0DomainTSP type-1 4
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522972_10297651096.0DomainTSP type-1 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+6341242_15252542016.0DomainProtein kinase
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634632_8262542016.0DomainRoc
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+161242_15250265.0DomainProtein kinase
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16632_8260265.0DomainRoc
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+6341248_12562542016.0Nucleotide bindingATP
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+161248_12560265.0Nucleotide bindingATP
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634279_3002542016.0RepeatNote=LRR 1
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634303_3242542016.0RepeatNote=LRR 2
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634330_3512542016.0RepeatNote=LRR 3
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634353_3742542016.0RepeatNote=LRR 4
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634381_4022542016.0RepeatNote=LRR 5
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634405_4262542016.0RepeatNote=LRR 6
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634427_4472542016.0RepeatNote=LRR 7
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634451_4722542016.0RepeatNote=LRR 8
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634474_4952542016.0RepeatNote=LRR 9
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634498_5192542016.0RepeatNote=LRR 10
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634549_5702542016.0RepeatNote=LRR 11
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634572_5942542016.0RepeatNote=LRR 12
HgeneLRRK1chr15:101529603chr15:100591936ENST00000388948+634596_6172542016.0RepeatNote=LRR 13
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16119_1480265.0RepeatNote=ANK 2
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16152_1820265.0RepeatNote=ANK 3
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16193_2220265.0RepeatNote=ANK 4
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16279_3000265.0RepeatNote=LRR 1
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16303_3240265.0RepeatNote=LRR 2
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16330_3510265.0RepeatNote=LRR 3
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16353_3740265.0RepeatNote=LRR 4
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16381_4020265.0RepeatNote=LRR 5
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16405_4260265.0RepeatNote=LRR 6
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16427_4470265.0RepeatNote=LRR 7
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16451_4720265.0RepeatNote=LRR 8
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16474_4950265.0RepeatNote=LRR 9
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16498_5190265.0RepeatNote=LRR 10
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16549_5700265.0RepeatNote=LRR 11
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16572_5940265.0RepeatNote=LRR 12
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+16596_6170265.0RepeatNote=LRR 13
HgeneLRRK1chr15:101529603chr15:100591936ENST00000532029+1686_1160265.0RepeatNote=ANK 1
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522599_7017651096.0Compositional biasNote=Cys-rich
TgeneADAMTS17chr15:101529603chr15:100591936ENST00000268070152260_1207651096.0Compositional biasNote=Arg-rich
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522232_4527651096.0DomainPeptidase M12B
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522453_5427651096.0DomainNote=Disintegrin
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522543_5987651096.0DomainTSP type-1 1
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522199_2067651096.0MotifCysteine switch
TgeneADAMTS17chr15:101529603chr15:100591936ENST000002680701522702_7797651096.0RegionNote=Spacer


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Fusion Gene Sequence for LRRK1-ADAMTS17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50105_50105_1_LRRK1-ADAMTS17_LRRK1_chr15_101529603_ENST00000284395_ADAMTS17_chr15_100591936_ENST00000268070_length(transcript)=4959nt_BP=1153nt
GCTGGCGGCGGCCTTGCTCTGCGCGCTCTTCGCGCCGCCCTCCCCGCCCGCCCGCCTCAGGATTGAGGAAGTGCGTCTGGGCCCGGCCCC
GGCGCGGGGGGCAGACGGCGGTGGGACGGCCAGGCCCCGGCCCCGCCAGTGTGTCCGCCCGGCCCCGCGTCCCGGAGCGCCCGCACCCGG
CCCCGCCGCCGCCTCAGAGCAAGAAAGCTTTCTGCTCAGCCATGGCTACGAGTCCACGCCTTAATGCACCCCACAGCCAGCGGCAGTGGC
AGTGACAACAGCGGGACCTGCCTTTGAAGATCGGCTGCTGCAAGGGTTGATGGCTGGCATGTCGCAAAGACCCCCCAGCATGTACTGGTG
TGTGGGGCCGGAGGAGTCAGCTGTGTGTCCAGAACGTGCCATGGAGACGCTTAACGGTGCCGGGGACACGGGCGGCAAGCCGTCCACGCG
GGGCGGTGACCCTGCAGCGCGGTCCCGCAGGACGGAAGGCATCCGCGCCGCGTACAGGCGGGGAGACCGCGGCGGCGCCCGGGACCTGCT
GGAGGAGGCCTGCGACCAGTGCGCGTCCCAGCTGGAAAAGGGCCAGCTTCTGAGCATCCCGGCAGCCTATGGGGATCTGGAGATGGTCCG
CTACCTACTCAGCAAGAGACTGGTGGAGCTGCCCACCGAGCCCACGGATGACAACCCAGCCGTGGTGGCAGCGTATTTTGGACACACGGC
AGTTGTGCAGGAATTGCTTGAGCCATTGACACCCAAACAAACAGAGTGGGAACAAACAGCACCCTTCAGTGGCACTTTCCCTTTGTCCTG
CCATCTCCTGCCAGGTCCCTGCAGTCCCCAGCGGCTTCTGAACTGGATGCTGGCCTTGGCTTGCCAGCGAGGGCACCTGGGGGTTGTGAA
GCTCCTGGTCCTGACGCACGGGGCTGACCCGGAGAGCTACGCTGTCAGGAAGAATGAGTTCCCTGTCATCGTGCGCTTGCCCCTGTATGC
GGCCATCAAGTCAGGGAATGAAGACATTGCAATATTCCTGCTTCGGCATGGGGCCTATTTCTGTTCCTACATCTTGCTGGATAGTCCTGA
CCCCAGCAAACATCTGCTGAGAAAGTACTTCATTGAAGCCAGTCCCTTGCCCAGCAGTTATCCGGGAAAAACAGTGTTGTTATTTCACGA
CCAAGATTATGGAATTCATTATGAATACACTGTTCCTGTAAACCGCACTGCGGAAAATCAAAGCGAACCAGAAAAACCGCAGGACTCTTT
GTTCATCTGGACCCACAGCGGCTGGGAAGGGTGCAGTGTGCAGTGCGGCGGAGGGGAGCGCAGAACCATCGTCTCGTGTACACGGATTGT
CAACAAGACCACAACTCTGGTGAACGACAGTGACTGCCCTCAAGCAAGCCGCCCAGAGCCCCAGGTCCGAAGGTGCAACTTGCACCCCTG
CCAGTCACGGTGGGTGGCAGGCCCGTGGAGCCCCTGCTCGGCGACCTGTGAGAAAGGCTTCCAGCACCGGGAGGTGACCTGCGTGTACCA
GCTGCAGAACGGCACACACGTCGCTACGCGGCCCCTCTACTGCCCGGGCCCCCGGCCGGCGGCAGTGCAGAGCTGTGAAGGCCAGGACTG
CCTGTCCATCTGGGAGGCGTCTGAGTGGTCACAGTGCTCTGCCAGCTGTGGTAAAGGGGTGTGGAAACGGACCGTGGCGTGCACCAACTC
ACAAGGGAAATGCGACGCATCCACGAGGCCGAGAGCCGAGGAGGCCTGCGAGGACTACTCAGGCTGCTACGAGTGGAAAACTGGGGACTG
GTCTACGTGCTCGTCGACCTGCGGGAAGGGCCTGCAGTCCCGGGTGGTGCAGTGCATGCACAAGGTCACAGGGCGCCACGGCAGCGAGTG
CCCCGCCCTCTCGAAGCCTGCCCCCTACAGACAGTGCTACCAGGAGGTCTGCAACGACAGGATCAACGCCAACACCATCACCTCCCCCCG
CCTTGCTGCTCTGACCTACAAATGCACACGAGACCAGTGGACGGTATATTGCCGGGTCATCCGAGAAAAGAACCTCTGCCAGGACATGCG
GTGGTACCAGCGCTGCTGCCAGACCTGCAGGGACTTCTATGCAAACAAGATGCGCCAGCCACCGCCGAACTCGTGACACGCAGTCCCAAG
GGTCGCTCAAAGCTCAGACTCAGGTCTGAAACCCACCCACCCGCAAGCCTACCAGCCTTGTGGCCACGCCCCCACCCGGCTGCCACAAGA
ATCCAACTACATAGAACATGAGCGTGGACTTGGCGTTTGCCATTAGTGCTTCCGTACTTAATATATTGTTAACAGCCACTGGCTGGCTTT
CTACAGTGAGGAGAAAGTAGGCATGAGTCACAAAGTAACTTCAATTTCTAGGATTTCAGGTACCTCGAAGGGAAGCACCTCTGGCAGACA
ACCGTCAAGAGAGAGACATCATTTAGTGTTCTTGTCTTGACTCGCTTTTGACATTTGAATTTCCAGTGCTTGGTATATCATGGAGGAAAC
ATCCCCAAAACGAGACATGCTAGAAAAGGCTTTATTCTGAAAGCCGGCGACACCATGGAGGGAGGGGCAGGTGTTGGTGAGCCTCTGCCC
GTGGCTTCTCTGGGGAGGGCCGGGCTGCTTAGCACACGTTTCTCTCCATCTACCTTCTTGACCACATGAGAACCAGGACGTTGCCTCCAT
GCCCGTCTCTGAGAACATAGTCTCTAAATCCTAGGTGTTGCCTTGGAAGTCTCGTGCGTGGAGTGTAAATCTATATATGCCAGCGAGGAC
AGCAGTGCCACGCAGTTCATACCACCCGCATGGGAAGAATGTTCCAAGAGAGTCTGGGTTTGGGGAAGCATCTAATTTTCAGAGCTCTGC
TGTCCACCGTGTAGGGAAACAGAAGGGCCTCTCTTCAAGGTGCTGTGACATAAGAAACGGTAATTGCGGTGATGGGGTTGCTTCCTAAGG
CAAAGGTAAGCTTGGGCCAGCTTCACTGGGGCGGATGGGCACCTGCCCCGCCTTCCGGGAACATCCACTCTGGCCTGCACTTCCTAAAGC
TTTGTACCTTAGAGATGCTGTACCACATCCCAGTGGCTTTCTACCGACCGTGGCCATTTATCTGAAGGTAAGACGACATTTGGGACCTCT
GAGGACACAAGCCCAGGCCTAGGATCTGTAGAGCAAGGCCTGACTGCTCTATCCTGGCACGGAGCAGCCTGATGTGCCAGGACCAGGGGA
GGAACGCCATCTGGCTGGCACTGCTGCACACCCGCCGAGCCTTCCTGTAGCCCCAGACTTTGTGGTACCCATTATCATCACGCCTGTCAT
CATTGACCCATCTTCTTGGTGGGGCAAGGATGATGCATGATGAAGGAAGGTCCTTCCCCCCTGCAGCCCCCTTACGCCTGGCAGCAGACA
AGCAGAGTGGCCTCTTTGAGAGCACAGAGGATGGTAGCACCCTACCTGCAAGGAGGCCGGGCAGGGACCCTAGATGCCAGGAGGCCTGTT
TTGCTCACCAACTTGGTGGGCATTTCATGGGTGCTTATGTTCTAGGACTTTACCGTAAATAACACCTCCTCCCTGATTTCAGACGGAAGG
TCTCACTTGGACTTCCATGGGATCATCTCCCTGTGCTTCTTGATTTATTGGTGCTGTGTTTCTGTGTTTTGTTTTGTTACATGTCACAAC
CGTAGAGTTAGCTTAAATCAGAAAGAAGCCTCTCTGCCTTCTCCACCCTGTCTTACGAGCTGTGTTTTTGTTTTTACTACCCTAGAGGCA
GAGAAGCGGTAGGGATGTCAGGGAATTTACTCACTTCCACTTGAATCAACGAGAAGTGTTGAGAAACTTCCGTGGGTGCTCTGTGGAAAG
AACCGAGGGTGTCAGGATGGAGCGGCCCACCCTCGCCCCGCGGCCTGCGCAGACTGCTGTCCTCCCCTTCAGGCCTGGCCACCAGCAGAC
TCCCATGAATTCCCATTTTCACAAAGCCCTCAAAATTTTGGGGGCGCTGAGGTTCAATTTTCTTCATCCCCAAATGAACTGTTAATTCAC
TGAAAGACATTTAGACTTTTGCAGCCAAGGAGCAGAGCCGGGCAAGCTCACTAAGGAAGCCTTAGCTTGGTCTCCTGCATGGGCCCCGGG
GCCTCCAGATATGCCCACTGTCACCCTGGCAAGGGCCCCACACCCTCAGAATGAAAAGGATTGATTGGGTTATTGTCAGATACCCCCATT
AGTTCCCCTAAAGTCTGCATCTGCAGAGCTCTTTTAGCTCATCTTTTTGTTGTCGGTGTTGTTTTTTGAGACAGAGTCTCCCTCTGTTGC
CCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCATTGAAAGCTCCGCCTCCCGGGTTCAGGCCATTCTTCTGCCTCACCCTCCCCAGTAG
CTGGGACTACAGGCGCCCACCACCACGCCCACCTACTTTTTTGTATTTTTACTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTC
GATCTCCTGACCTCATGATCCACCCGCCTCAGCCTTCCAAAGTGCTGGGATTACAGGAGTGAGCCACCGCGCCCGGCCTTTTAGCTTATC
TTGAAATCCACCAGCCTACCTTCTGTTCATGGCACGAGCAGTGATTTCAGTGAAACCATCATAAACATTCTTGTTCCACTAGATGCTGAT
CACAGCAGTGATGTTTCTGTGTTAATACCCTGTACTGTCCCTCGAGTACTGTACCTTTGTGCTTGCACACGTGTCACTAACGCACGTGTT
ACCAGAGTCTCACGACCCTACGGTGCTATTTTTATTGGTGCAAAATTAAACCCTCTCAGCTGACCGTTGCTGGATAGGATCAGAATGCAG
GAAAAGAGCCTCTATGGCAATACGATTGTCCTTTTTTCGTTTCAGAGTCAAATGTATCTATTTTCCATTCGTTAACTTGCATTACATACT

>50105_50105_1_LRRK1-ADAMTS17_LRRK1_chr15_101529603_ENST00000284395_ADAMTS17_chr15_100591936_ENST00000268070_length(amino acids)=613AA_BP=283
MLQGLMAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACDQCASQL
EKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLEPLTPKQTEWEQTAPFSGTFPLSCHLLPGPCSPQR
LLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFI
EASPLPSSYPGKTVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSD
CPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQ
CSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQ

--------------------------------------------------------------
>50105_50105_2_LRRK1-ADAMTS17_LRRK1_chr15_101529603_ENST00000388948_ADAMTS17_chr15_100591936_ENST00000268070_length(transcript)=4927nt_BP=1121nt
GCGGCCGCCGAGGGGACGCCTCGCGACGGTTCCTGGGAGAGCTGGCGGCGGCCTTGCTCTGCGCGCTCTTCGCGCCGCCCTCCCCGCCCG
CCCGCCTCAGGATTGAGGAAGTGCGTCTGGGCCCGGCCCCGGCGCGGGGGGCAGACGGCGGTGGGACGGCCAGGCCCCGGCCCCGCCAGT
GTGTCCGCCCGGCCCCGCGTCCCGGAGCGCCCGCACCCGGCCCCGCCGCCGCCTCAGAGCAAGAAAGCTTTCTGCTCAGCCATGGCTACG
AGTCCACGCCTTAATGCACCCCACAGCCAGCGGCAGTGGCAGTGACAACAGCGGGACCTGCCTTTGAAGATCGGCTGCTGCAAGGGTTGA
TGGCTGGCATGTCGCAAAGACCCCCCAGCATGTACTGGTGTGTGGGGCCGGAGGAGTCAGCTGTGTGTCCAGAACGTGCCATGGAGACGC
TTAACGGTGCCGGGGACACGGGCGGCAAGCCGTCCACGCGGGGCGGTGACCCTGCAGCGCGGTCCCGCAGGACGGAAGGCATCCGCGCCG
CGTACAGGCGGGGAGACCGCGGCGGCGCCCGGGACCTGCTGGAGGAGGCCTGCGACCAGTGCGCGTCCCAGCTGGAAAAGGGCCAGCTTC
TGAGCATCCCGGCAGCCTATGGGGATCTGGAGATGGTCCGCTACCTACTCAGCAAGAGACTGGTGGAGCTGCCCACCGAGCCCACGGATG
ACAACCCAGCCGTGGTGGCAGCGTATTTTGGACACACGGCAGTTGTGCAGGAATTGCTTGAGTCCTTACCAGGTCCCTGCAGTCCCCAGC
GGCTTCTGAACTGGATGCTGGCCTTGGCTTGCCAGCGAGGGCACCTGGGGGTTGTGAAGCTCCTGGTCCTGACGCACGGGGCTGACCCGG
AGAGCTACGCTGTCAGGAAGAATGAGTTCCCTGTCATCGTGCGCTTGCCCCTGTATGCGGCCATCAAGTCAGGGAATGAAGACATTGCAA
TATTCCTGCTTCGGCATGGGGCCTATTTCTGTTCCTACATCTTGCTGGATAGTCCTGACCCCAGCAAACATCTGCTGAGAAAGTACTTCA
TTGAAGCCAGTCCCTTGCCCAGCAGTTATCCGGGAAAAACAGTGTTGTTATTTCACGACCAAGATTATGGAATTCATTATGAATACACTG
TTCCTGTAAACCGCACTGCGGAAAATCAAAGCGAACCAGAAAAACCGCAGGACTCTTTGTTCATCTGGACCCACAGCGGCTGGGAAGGGT
GCAGTGTGCAGTGCGGCGGAGGGGAGCGCAGAACCATCGTCTCGTGTACACGGATTGTCAACAAGACCACAACTCTGGTGAACGACAGTG
ACTGCCCTCAAGCAAGCCGCCCAGAGCCCCAGGTCCGAAGGTGCAACTTGCACCCCTGCCAGTCACGGTGGGTGGCAGGCCCGTGGAGCC
CCTGCTCGGCGACCTGTGAGAAAGGCTTCCAGCACCGGGAGGTGACCTGCGTGTACCAGCTGCAGAACGGCACACACGTCGCTACGCGGC
CCCTCTACTGCCCGGGCCCCCGGCCGGCGGCAGTGCAGAGCTGTGAAGGCCAGGACTGCCTGTCCATCTGGGAGGCGTCTGAGTGGTCAC
AGTGCTCTGCCAGCTGTGGTAAAGGGGTGTGGAAACGGACCGTGGCGTGCACCAACTCACAAGGGAAATGCGACGCATCCACGAGGCCGA
GAGCCGAGGAGGCCTGCGAGGACTACTCAGGCTGCTACGAGTGGAAAACTGGGGACTGGTCTACGTGCTCGTCGACCTGCGGGAAGGGCC
TGCAGTCCCGGGTGGTGCAGTGCATGCACAAGGTCACAGGGCGCCACGGCAGCGAGTGCCCCGCCCTCTCGAAGCCTGCCCCCTACAGAC
AGTGCTACCAGGAGGTCTGCAACGACAGGATCAACGCCAACACCATCACCTCCCCCCGCCTTGCTGCTCTGACCTACAAATGCACACGAG
ACCAGTGGACGGTATATTGCCGGGTCATCCGAGAAAAGAACCTCTGCCAGGACATGCGGTGGTACCAGCGCTGCTGCCAGACCTGCAGGG
ACTTCTATGCAAACAAGATGCGCCAGCCACCGCCGAACTCGTGACACGCAGTCCCAAGGGTCGCTCAAAGCTCAGACTCAGGTCTGAAAC
CCACCCACCCGCAAGCCTACCAGCCTTGTGGCCACGCCCCCACCCGGCTGCCACAAGAATCCAACTACATAGAACATGAGCGTGGACTTG
GCGTTTGCCATTAGTGCTTCCGTACTTAATATATTGTTAACAGCCACTGGCTGGCTTTCTACAGTGAGGAGAAAGTAGGCATGAGTCACA
AAGTAACTTCAATTTCTAGGATTTCAGGTACCTCGAAGGGAAGCACCTCTGGCAGACAACCGTCAAGAGAGAGACATCATTTAGTGTTCT
TGTCTTGACTCGCTTTTGACATTTGAATTTCCAGTGCTTGGTATATCATGGAGGAAACATCCCCAAAACGAGACATGCTAGAAAAGGCTT
TATTCTGAAAGCCGGCGACACCATGGAGGGAGGGGCAGGTGTTGGTGAGCCTCTGCCCGTGGCTTCTCTGGGGAGGGCCGGGCTGCTTAG
CACACGTTTCTCTCCATCTACCTTCTTGACCACATGAGAACCAGGACGTTGCCTCCATGCCCGTCTCTGAGAACATAGTCTCTAAATCCT
AGGTGTTGCCTTGGAAGTCTCGTGCGTGGAGTGTAAATCTATATATGCCAGCGAGGACAGCAGTGCCACGCAGTTCATACCACCCGCATG
GGAAGAATGTTCCAAGAGAGTCTGGGTTTGGGGAAGCATCTAATTTTCAGAGCTCTGCTGTCCACCGTGTAGGGAAACAGAAGGGCCTCT
CTTCAAGGTGCTGTGACATAAGAAACGGTAATTGCGGTGATGGGGTTGCTTCCTAAGGCAAAGGTAAGCTTGGGCCAGCTTCACTGGGGC
GGATGGGCACCTGCCCCGCCTTCCGGGAACATCCACTCTGGCCTGCACTTCCTAAAGCTTTGTACCTTAGAGATGCTGTACCACATCCCA
GTGGCTTTCTACCGACCGTGGCCATTTATCTGAAGGTAAGACGACATTTGGGACCTCTGAGGACACAAGCCCAGGCCTAGGATCTGTAGA
GCAAGGCCTGACTGCTCTATCCTGGCACGGAGCAGCCTGATGTGCCAGGACCAGGGGAGGAACGCCATCTGGCTGGCACTGCTGCACACC
CGCCGAGCCTTCCTGTAGCCCCAGACTTTGTGGTACCCATTATCATCACGCCTGTCATCATTGACCCATCTTCTTGGTGGGGCAAGGATG
ATGCATGATGAAGGAAGGTCCTTCCCCCCTGCAGCCCCCTTACGCCTGGCAGCAGACAAGCAGAGTGGCCTCTTTGAGAGCACAGAGGAT
GGTAGCACCCTACCTGCAAGGAGGCCGGGCAGGGACCCTAGATGCCAGGAGGCCTGTTTTGCTCACCAACTTGGTGGGCATTTCATGGGT
GCTTATGTTCTAGGACTTTACCGTAAATAACACCTCCTCCCTGATTTCAGACGGAAGGTCTCACTTGGACTTCCATGGGATCATCTCCCT
GTGCTTCTTGATTTATTGGTGCTGTGTTTCTGTGTTTTGTTTTGTTACATGTCACAACCGTAGAGTTAGCTTAAATCAGAAAGAAGCCTC
TCTGCCTTCTCCACCCTGTCTTACGAGCTGTGTTTTTGTTTTTACTACCCTAGAGGCAGAGAAGCGGTAGGGATGTCAGGGAATTTACTC
ACTTCCACTTGAATCAACGAGAAGTGTTGAGAAACTTCCGTGGGTGCTCTGTGGAAAGAACCGAGGGTGTCAGGATGGAGCGGCCCACCC
TCGCCCCGCGGCCTGCGCAGACTGCTGTCCTCCCCTTCAGGCCTGGCCACCAGCAGACTCCCATGAATTCCCATTTTCACAAAGCCCTCA
AAATTTTGGGGGCGCTGAGGTTCAATTTTCTTCATCCCCAAATGAACTGTTAATTCACTGAAAGACATTTAGACTTTTGCAGCCAAGGAG
CAGAGCCGGGCAAGCTCACTAAGGAAGCCTTAGCTTGGTCTCCTGCATGGGCCCCGGGGCCTCCAGATATGCCCACTGTCACCCTGGCAA
GGGCCCCACACCCTCAGAATGAAAAGGATTGATTGGGTTATTGTCAGATACCCCCATTAGTTCCCCTAAAGTCTGCATCTGCAGAGCTCT
TTTAGCTCATCTTTTTGTTGTCGGTGTTGTTTTTTGAGACAGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCT
CATTGAAAGCTCCGCCTCCCGGGTTCAGGCCATTCTTCTGCCTCACCCTCCCCAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCAC
CTACTTTTTTGTATTTTTACTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCACCCGCCTCAG
CCTTCCAAAGTGCTGGGATTACAGGAGTGAGCCACCGCGCCCGGCCTTTTAGCTTATCTTGAAATCCACCAGCCTACCTTCTGTTCATGG
CACGAGCAGTGATTTCAGTGAAACCATCATAAACATTCTTGTTCCACTAGATGCTGATCACAGCAGTGATGTTTCTGTGTTAATACCCTG
TACTGTCCCTCGAGTACTGTACCTTTGTGCTTGCACACGTGTCACTAACGCACGTGTTACCAGAGTCTCACGACCCTACGGTGCTATTTT
TATTGGTGCAAAATTAAACCCTCTCAGCTGACCGTTGCTGGATAGGATCAGAATGCAGGAAAAGAGCCTCTATGGCAATACGATTGTCCT

>50105_50105_2_LRRK1-ADAMTS17_LRRK1_chr15_101529603_ENST00000388948_ADAMTS17_chr15_100591936_ENST00000268070_length(amino acids)=589AA_BP=259
MLQGLMAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACDQCASQL
EKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLT
HGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTVLLFHDQDYGI
HYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWV
AGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCD
ASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALT

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Fusion Gene PPI Analysis for LRRK1-ADAMTS17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRRK1-ADAMTS17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRRK1-ADAMTS17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource