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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANXA11-MXI1 (FusionGDB2 ID:5011)

Fusion Gene Summary for ANXA11-MXI1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA11-MXI1
Fusion gene ID: 5011
HgeneTgene
Gene symbol

ANXA11

MXI1

Gene ID

311

4601

Gene nameannexin A11MAX interactor 1, dimerization protein
SynonymsALS23|ANX11|CAP-50|CAP50MAD2|MXD2|MXI|bHLHc11
Cytomap

10q22.3

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionannexin A1156 kDa autoantigenannexin XIannexin-11calcyclin-associated annexin 50epididymis secretory sperm binding proteinmax-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11
Modification date2020031320200313
UniProtAcc

P50995

P50539

Ensembl transtripts involved in fusion geneENST00000265447, ENST00000360615, 
ENST00000372231, ENST00000422982, 
ENST00000438331, ENST00000463657, 
ENST00000537102, ENST00000535999, 
ENST00000332674, ENST00000485566, 
ENST00000239007, ENST00000361248, 
ENST00000369612, ENST00000393134, 
Fusion gene scores* DoF score11 X 8 X 4=35217 X 10 X 9=1530
# samples 1119
** MAII scorelog2(11/352*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1530*10)=-3.00946032924907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANXA11 [Title/Abstract] AND MXI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANXA11(81965099)-MXI1(111987947), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA11

GO:0051592

response to calcium ion

9188810|12601007

TgeneMXI1

GO:0000122

negative regulation of transcription by RNA polymerase II

11875718


check buttonFusion gene breakpoints across ANXA11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MXI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01AANXA11chr10

81965099

-MXI1chr10

111987947

+


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Fusion Gene ORF analysis for ANXA11-MXI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000265447ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3CDSENST00000360615ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3CDSENST00000372231ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3CDSENST00000422982ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3CDSENST00000438331ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3CDSENST00000463657ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3CDSENST00000537102ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3UTRENST00000265447ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3UTRENST00000360615ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3UTRENST00000372231ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3UTRENST00000422982ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3UTRENST00000438331ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3UTRENST00000463657ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-3UTRENST00000537102ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000265447ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000265447ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000265447ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000265447ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000360615ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000360615ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000360615ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000360615ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000372231ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000372231ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000372231ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000372231ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000422982ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000422982ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000422982ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000422982ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000438331ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000438331ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000438331ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000438331ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000463657ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000463657ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000463657ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000463657ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000537102ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000537102ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000537102ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
5UTR-5UTRENST00000537102ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+
intron-3CDSENST00000535999ENST00000332674ANXA11chr10

81965099

-MXI1chr10

111987947

+
intron-3UTRENST00000535999ENST00000485566ANXA11chr10

81965099

-MXI1chr10

111987947

+
intron-5UTRENST00000535999ENST00000239007ANXA11chr10

81965099

-MXI1chr10

111987947

+
intron-5UTRENST00000535999ENST00000361248ANXA11chr10

81965099

-MXI1chr10

111987947

+
intron-5UTRENST00000535999ENST00000369612ANXA11chr10

81965099

-MXI1chr10

111987947

+
intron-5UTRENST00000535999ENST00000393134ANXA11chr10

81965099

-MXI1chr10

111987947

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANXA11-MXI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANXA11chr1081965094-MXI1chr10111987946+5.02E-070.9999995
ANXA11chr1081965094-MXI1chr10111987946+5.02E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANXA11-MXI1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:81965099/:111987947)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANXA11

P50995

MXI1

P50539

FUNCTION: Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis. {ECO:0000250, ECO:0000269|PubMed:15197175}.FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANXA11-MXI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANXA11-MXI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANXA11-MXI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANXA11-MXI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource