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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LSM12-TIA1 (FusionGDB2 ID:50180)

Fusion Gene Summary for LSM12-TIA1

Fusion gene summary

Fusion gene information	Fusion gene name: LSM12-TIA1
	Fusion gene ID: 50180
		Hgene	Tgene
	Gene symbol	LSM12	TIA1
	Gene ID	124801	7072
	Gene name	LSM12 homolog	TIA1 cytotoxic granule associated RNA binding protein
	Synonyms	PNAS-135	TIA-1\|WDM
	Cytomap	17q21.31	2p13.3
	Type of gene	protein-coding	protein-coding
	Description	protein LSM12 homolog	nucleolysin TIA-1 isoform p40nucleolysin TIA-1T-cell-restricted intracellular antigen-1p40-TIA-1 (containing p15-TIA-1)
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000293406, ENST00000585388, ENST00000591247,	ENST00000416149, ENST00000482876, ENST00000282574, ENST00000415783, ENST00000433529, ENST00000445587,
Fusion gene scores	* DoF score	5 X 5 X 5=125	11 X 6 X 6=396
	# samples	6	11
	** MAII score	log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LSM12 [Title/Abstract] AND TIA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LSM12(42141168)-TIA1(70444126), # samples:1
Anticipated loss of major functional domain due to fusion event.	LSM12-TIA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TIA1	GO:0048024	regulation of mRNA splicing, via spliceosome	11106748

Fusion gene breakpoints across LSM12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TIA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A43C	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-

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Fusion Gene ORF analysis for LSM12-TIA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000293406	ENST00000416149	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
5CDS-5UTR	ENST00000293406	ENST00000482876	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
5CDS-5UTR	ENST00000585388	ENST00000416149	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
5CDS-5UTR	ENST00000585388	ENST00000482876	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
5CDS-5UTR	ENST00000591247	ENST00000416149	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
5CDS-5UTR	ENST00000591247	ENST00000482876	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
Frame-shift	ENST00000591247	ENST00000282574	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
Frame-shift	ENST00000591247	ENST00000415783	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
Frame-shift	ENST00000591247	ENST00000433529	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
Frame-shift	ENST00000591247	ENST00000445587	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000293406	ENST00000282574	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000293406	ENST00000415783	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000293406	ENST00000433529	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000293406	ENST00000445587	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000585388	ENST00000282574	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000585388	ENST00000415783	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000585388	ENST00000433529	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-
In-frame	ENST00000585388	ENST00000445587	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000293406	LSM12	chr17	42141168	-	ENST00000433529	TIA1	chr2	70444126	-	4368	406	85	1092	335
ENST00000293406	LSM12	chr17	42141168	-	ENST00000415783	TIA1	chr2	70444126	-	4368	406	85	1092	335
ENST00000293406	LSM12	chr17	42141168	-	ENST00000282574	TIA1	chr2	70444126	-	3605	406	85	1089	334
ENST00000293406	LSM12	chr17	42141168	-	ENST00000445587	TIA1	chr2	70444126	-	1225	406	85	822	245
ENST00000585388	LSM12	chr17	42141168	-	ENST00000433529	TIA1	chr2	70444126	-	4292	330	9	1016	335
ENST00000585388	LSM12	chr17	42141168	-	ENST00000415783	TIA1	chr2	70444126	-	4292	330	9	1016	335
ENST00000585388	LSM12	chr17	42141168	-	ENST00000282574	TIA1	chr2	70444126	-	3529	330	9	1013	334
ENST00000585388	LSM12	chr17	42141168	-	ENST00000445587	TIA1	chr2	70444126	-	1149	330	9	746	245

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000293406	ENST00000433529	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.000235388	0.9997646
ENST00000293406	ENST00000415783	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.000235388	0.9997646
ENST00000293406	ENST00000282574	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.000362651	0.99963737
ENST00000293406	ENST00000445587	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.001619516	0.9983804
ENST00000585388	ENST00000433529	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.000244404	0.99975556
ENST00000585388	ENST00000415783	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.000244404	0.99975556
ENST00000585388	ENST00000282574	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.000385868	0.9996141
ENST00000585388	ENST00000445587	LSM12	chr17	42141168	-	TIA1	chr2	70444126	-	0.001495405	0.99850464

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Fusion Genomic Features for LSM12-TIA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LSM12-TIA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:42141168/chr2:70444126)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TIA1

chr17:42141168

chr2:70444126

ENST00000415783

214_286

147

376.0

Domain

RRM 3

Tgene

TIA1

chr17:42141168

chr2:70444126

ENST00000433529

214_286

158

387.0

Domain

RRM 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TIA1

chr17:42141168

chr2:70444126

ENST00000415783

106_184

147

376.0

Domain

RRM 2

Tgene

TIA1

chr17:42141168

chr2:70444126

ENST00000415783

7_83

147

376.0

Domain

RRM 1

Tgene

TIA1

chr17:42141168

chr2:70444126

ENST00000433529

106_184

158

387.0

Domain

RRM 2

Tgene

TIA1

chr17:42141168

chr2:70444126

ENST00000433529

7_83

158

387.0

Domain

RRM 1

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Fusion Gene Sequence for LSM12-TIA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50180_50180_1_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000282574_length(transcript)=3605nt_BP=406nt
AGGATCCCGCCCCAACCAGCGCCAGGCCACGCCCCGGCGTGTGACGCAAGCACGCTCCGTGCGCGCCGTCGCGTCGCGGCGCTCACTGGG
GGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGCGAGTACTTCAGCGT
TGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCCAAAATGCTGGCTTT
AAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTGGAAATAATTAATGA
CCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGTGGCCAGTGGCTTGG
TGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAACAGCTATCATATGA
TGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAACTAATGCGTCAGAC
TTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGGTTCAATTCCCATGAAAGTGCAGC
ACATGCAATTGTTTCTGTTAATGGTACTACCATTGAAGGTCATGTTGTGAAATGCTATTGGGGCAAAGAAACTCTTGATATGATAAATCC
CGTGCAACAGAATCAAATTGGATATCCCCAACCTTATGGCCAGTGGGGCCAGTGGTATGGAAATGCACAACAAATTGGCCAGTATATGCC
TAATGGTTGGCAAGTTCCTGCATATGGAATGTATGGCCAGGCATGGAACCAGCAAGGATTTAATCAGACACAGTCTTCTGCACCATGGAT
GGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTATCGAGTGGCAGGGTATGA
AACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGTTTACTTAAAGATTTATC
AAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTATCATCCACATTGTTTTAA
AAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTTGTTTCAAACACAAATGC
AGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTAGTGTGCAGTTCTAGTTT
GCATTCCTGATATGATTTAAAACATGTAATATAAAGATGTTAAAAAAAAAAACCAAAACTGTGCAGAGTCTAGAAGTTGTTTGTCATCTT
CAGCTTGTGCACAATTCTGTTTTAGGTTAAAAAAAGGCATTGTTTGAGCTGTCCCATCTCCACTGTTATCCCTTTGGGGTTTTTTAATAT
AAATTATTAGTTTACATCATTTTTGTATCTACATCTTTTTTCACAAATTTGTCTTGCCTTATTAAAGTTCTGTAAAATATACTTAAATGG
AAAAAATGATGTTCATTTAGATTGAAAACTTTTCTCAGATGGATTGATAATTGCATTCATCTTGTGTTTTATATGAGAAGGTGCCTCAAG
AATTTCCTGTTGGATTTGTTTAAAAGGATTTTTATCTTTCGTGATAAACTTTGCTGTGTACCAGGAACTATAAAAACAAAAACTTGTTAC
TAAAGAAAATATCTGAAATGTGATAAGTTCTTATGCCATGTTAATTTCATGTGTCAACTTCAACATTTACATGTATTATTTCATTATGTA
AAATGTTTTAGCAATTTAATATTTTGCACAGTTAGCAAACTTTGTATGTCATTTCCTTCAAGGCATCATGCAGAGTTGACATGAGATTTA
TAAGGTTTTAAGTTGTTTGCATGTGAAAATCAAATACATACTTTGGTAGTCTTTGAATACAAAGTCATCTGCTCTTGTTTTTCAAGAATT
TTGAGACACAAAGTTGTATGTAAAGGAATATATTAATTTGCCGTTTTCTAGGTAGATTTGCTCAAAAAGAGTGAATCAACTTAATATGTA
CAAATGATAGCTGTGAAACTGTAGAATATCTTTGTGTCAGGCTTGGAGTTCATTGTGACCTCCAAATTTTGCCTGAAGGACCAGCTGGGC
AAAGCATCTTTTAAATGTTCAGAGGCCAAAAGATAAACAAAAAAAAAACCTTAAAATCCTACCTCTTTAAACAGCCTTCAGATAAGAGAA
TCCTCAGTGCAATCATTATTTTGATTCGTTTGGTACCTGTTTTCCTGGAGTTCCCGATTTTATTATTTTGGGGTGGCTCCAAGCATTAAG
AGGTTTAATCTTTGATGGCATTGTTCTAGTTTTGAAATTTCTAGTATATTTCAGAGTCTCTTAGAAGACTTGTGTGGGAAGTTTCACTTT
GTTTTCAGTGAAGATCACAAACCTCCTTCTTCCTTTACTCAAGAGGAAAGGTCCCAGTATACATATTTGAATGGTTGATGGTTTTCAAGA
CCTTCAGGGAGCTCCCTGCATTTTACCTAGAAACAGAAAAGGCCCGCAAAATCTTAAGTTTCCTGGCCTGCATTTCCCGGGTAGGGGCAA
ATGACTCCAAGCTGGTCTCTAAGCCAATACCCTTATAAACCAGAGCCCAGGAAAGACAGCTCGAGTGTATAATTCTCTGGAGCTCAATTC
TATGCAGTTGTGCTGATATTTCATTAAGTCACTGTGTATTTTTAAGTGTTGATACATTAAAAGTCGCTTTATGGAAGATGAGTAAATTTT
TTAAATACTTGGAAATTTTATTTCCTTGTTAACTTCTACAGATCAGGGCATGCAACCAAAAGCAGCTTAAATGAAATATTTTAAAATAAA
ATATCAGGAAGCTATTTTTAGATTTCTTCTGGCTTATGTTTCTACTTTAGGACCCTCATTGTTCTCTTATTAAAAAAAATTATTTCCTGT
GCATCTCATGGACTGCAGGGTAAATTATTTGGGCATAAATAATTTAAATAGTTTTCTTTCATTTTGACTATCTCCAGTAATAACAGTTTT
TATTATCCAGCATATTGGCTTATTGCACAAATCTTAAAATGTACATTGACTACTTTCTGAGAAGAAAGTGGTATCAGTACTCATGATGAA
AAGGTTACTACTGAACAAATTCACATTTCAGGAACACCTCTATCTTTGGTTTAAATCTTACTCTTAGTTTTTCCGTCTAAAAATCATACT
GGTATTAGTATCAGGTAAGGAAATTAAAGTTTTTAAAATGGTTTCATTCTCTGCAATATGCAAAATTTAGATTTTACTTTCTGGTACTGT
AAAGAACCTGAAGTGATTTACACTTAATGGGTGATTAATCCAGTATTCTTTACCCTGAATGTTTGGATATTAAAGTTCCTTTATGTTTTC

>50180_50180_1_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000282574_length(amino acids)=334AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR
QTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQNQIGYPQPYGQWGQWYGNAQQIGQY

--------------------------------------------------------------
>50180_50180_2_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000415783_length(transcript)=4368nt_BP=406nt
AGGATCCCGCCCCAACCAGCGCCAGGCCACGCCCCGGCGTGTGACGCAAGCACGCTCCGTGCGCGCCGTCGCGTCGCGGCGCTCACTGGG
GGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGCGAGTACTTCAGCGT
TGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCCAAAATGCTGGCTTT
AAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTGGAAATAATTAATGA
CCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGTGGCCAGTGGCTTGG
TGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAACAGCTATCATATGA
TGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAACTAATGCGTCAGAC
TTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGGTTCAATTCCCATGAAAGTGCAGC
ACATGCAATTGTTTCTGTTAATGGTACTACCATTGAAGGTCATGTTGTGAAATGCTATTGGGGCAAAGAAACTCTTGATATGATAAATCC
CGTGCAACAGCAGAATCAAATTGGATATCCCCAACCTTATGGCCAGTGGGGCCAGTGGTATGGAAATGCACAACAAATTGGCCAGTATAT
GCCTAATGGTTGGCAAGTTCCTGCATATGGAATGTATGGCCAGGCATGGAACCAGCAAGGATTTAATCAGACACAGTCTTCTGCACCATG
GATGGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTATCGAGTGGCAGGGTA
TGAAACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGTTTACTTAAAGATTT
ATCAAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTATCATCCACATTGTTT
TAAAAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTTGTTTCAAACACAAA
TGCAGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTAGTGTGCAGTTCTAG
TTTGCATTCCTGATATGATTTAAAACATGTAATATAAAGATGTTAAAAAAAAAAACCAAAACTGTGCAGAGTCTAGAAGTTGTTTGTCAT
CTTCAGCTTGTGCACAATTCTGTTTTAGGTTAAAAAAAGGCATTGTTTGAGCTGTCCCATCTCCACTGTTATCCCTTTGGGGTTTTTTAA
TATAAATTATTAGTTTACATCATTTTTGTATCTACATCTTTTTTCACAAATTTGTCTTGCCTTATTAAAGTTCTGTAAAATATACTTAAA
TGGAAAAAATGATGTTCATTTAGATTGAAAACTTTTCTCAGATGGATTGATAATTGCATTCATCTTGTGTTTTATATGAGAAGGTGCCTC
AAGAATTTCCTGTTGGATTTGTTTAAAAGGATTTTTATCTTTCGTGATAAACTTTGCTGTGTACCAGGAACTATAAAAACAAAAACTTGT
TACTAAAGAAAATATCTGAAATGTGATAAGTTCTTATGCCATGTTAATTTCATGTGTCAACTTCAACATTTACATGTATTATTTCATTAT
GTAAAATGTTTTAGCAATTTAATATTTTGCACAGTTAGCAAACTTTGTATGTCATTTCCTTCAAGGCATCATGCAGAGTTGACATGAGAT
TTATAAGGTTTTAAGTTGTTTGCATGTGAAAATCAAATACATACTTTGGTAGTCTTTGAATACAAAGTCATCTGCTCTTGTTTTTCAAGA
ATTTTGAGACACAAAGTTGTATGTAAAGGAATATATTAATTTGCCGTTTTCTAGGTAGATTTGCTCAAAAAGAGTGAATCAACTTAATAT
GTACAAATGATAGCTGTGAAACTGTAGAATATCTTTGTGTCAGGCTTGGAGTTCATTGTGACCTCCAAATTTTGCCTGAAGGACCAGCTG
GGCAAAGCATCTTTTAAATGTTCAGAGGCCAAAAGATAAACAAAAAAAAAACCTTAAAATCCTACCTCTTTAAACAGCCTTCAGATAAGA
GAATCCTCAGTGCAATCATTATTTTGATTCGTTTGGTACCTGTTTTCCTGGAGTTCCCGATTTTATTATTTTGGGGTGGCTCCAAGCATT
AAGAGGTTTAATCTTTGATGGCATTGTTCTAGTTTTGAAATTTCTAGTATATTTCAGAGTCTCTTAGAAGACTTGTGTGGGAAGTTTCAC
TTTGTTTTCAGTGAAGATCACAAACCTCCTTCTTCCTTTACTCAAGAGGAAAGGTCCCAGTATACATATTTGAATGGTTGATGGTTTTCA
AGACCTTCAGGGAGCTCCCTGCATTTTACCTAGAAACAGAAAAGGCCCGCAAAATCTTAAGTTTCCTGGCCTGCATTTCCCGGGTAGGGG
CAAATGACTCCAAGCTGGTCTCTAAGCCAATACCCTTATAAACCAGAGCCCAGGAAAGACAGCTCGAGTGTATAATTCTCTGGAGCTCAA
TTCTATGCAGTTGTGCTGATATTTCATTAAGTCACTGTGTATTTTTAAGTGTTGATACATTAAAAGTCGCTTTATGGAAGATGAGTAAAT
TTTTTAAATACTTGGAAATTTTATTTCCTTGTTAACTTCTACAGATCAGGGCATGCAACCAAAAGCAGCTTAAATGAAATATTTTAAAAT
AAAATATCAGGAAGCTATTTTTAGATTTCTTCTGGCTTATGTTTCTACTTTAGGACCCTCATTGTTCTCTTATTAAAAAAAATTATTTCC
TGTGCATCTCATGGACTGCAGGGTAAATTATTTGGGCATAAATAATTTAAATAGTTTTCTTTCATTTTGACTATCTCCAGTAATAACAGT
TTTTATTATCCAGCATATTGGCTTATTGCACAAATCTTAAAATGTACATTGACTACTTTCTGAGAAGAAAGTGGTATCAGTACTCATGAT
GAAAAGGTTACTACTGAACAAATTCACATTTCAGGAACACCTCTATCTTTGGTTTAAATCTTACTCTTAGTTTTTCCGTCTAAAAATCAT
ACTGGTATTAGTATCAGGTAAGGAAATTAAAGTTTTTAAAATGGTTTCATTCTCTGCAATATGCAAAATTTAGATTTTACTTTCTGGTAC
TGTAAAGAACCTGAAGTGATTTACACTTAATGGGTGATTAATCCAGTATTCTTTACCCTGAATGTTTGGATATTAAAGTTCCTTTATGTT
TTCTATAACCTGTGGGATCTTCTTGCAGTGATTATTGTGTGTGAGATTTTTTTTCTTTTTGGTCTATCCATATTGTTATATTCACTCAGG
TATTTTTTTTTTAATCTTATTCCAGAATCAGTGGTTTATATTGGGTTACTGTTTAACACCAAATGGAATTGGCATTCTGCAGATTTAATT
AATTATGAAACCAGGGTCTCATTTTCCTTGCTGATACTTGTTGAAAATGAGATTCACATTCTAGTCTTTATTTTCCTCCTGTTTTGTCCC
TGTGCTTGTACATCTTCCTTTTATTTGTGTGTTATAGTTCTATTCCATTTGAGAAGGCAGTTGGTAAGAACTAGATTGCATGTACAAAGA
CAGGTTTACTAAGTGCTGTACAGTGGTCCTGAGGTTACAGTTGAATTAGAAAAACGAAATGTACTTACAGGAAATAAGAAAGCAAACCTT
TCAAATGAGAGTGATGATTTCTTTAAAAAAAATCAGTTTTTTTCTCTCAAATAATGTTCTTTATTTCACGAAATCGTCAATCTTAAGCAT
GAGCAGGGATAAACAACTCCTAGAAGGAACTCAATTCATTCTTCCTGGATTTTCTCTGTTGTTAAATCACAAAAATGATAGTCCCCAATC
GTTTCTTTATAGGAGGTTATTACATTTCATTACAGTCACTGCATTTTGACTGTTGTGTTTAGAATTTGAATGTACATCCAAAATGATGAG

>50180_50180_2_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000415783_length(amino acids)=335AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR
QTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQIGQ

--------------------------------------------------------------
>50180_50180_3_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000433529_length(transcript)=4368nt_BP=406nt
AGGATCCCGCCCCAACCAGCGCCAGGCCACGCCCCGGCGTGTGACGCAAGCACGCTCCGTGCGCGCCGTCGCGTCGCGGCGCTCACTGGG
GGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGCGAGTACTTCAGCGT
TGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCCAAAATGCTGGCTTT
AAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTGGAAATAATTAATGA
CCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGTGGCCAGTGGCTTGG
TGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAACAGCTATCATATGA
TGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAACTAATGCGTCAGAC
TTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGGTTCAATTCCCATGAAAGTGCAGC
ACATGCAATTGTTTCTGTTAATGGTACTACCATTGAAGGTCATGTTGTGAAATGCTATTGGGGCAAAGAAACTCTTGATATGATAAATCC
CGTGCAACAGCAGAATCAAATTGGATATCCCCAACCTTATGGCCAGTGGGGCCAGTGGTATGGAAATGCACAACAAATTGGCCAGTATAT
GCCTAATGGTTGGCAAGTTCCTGCATATGGAATGTATGGCCAGGCATGGAACCAGCAAGGATTTAATCAGACACAGTCTTCTGCACCATG
GATGGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTATCGAGTGGCAGGGTA
TGAAACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGTTTACTTAAAGATTT
ATCAAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTATCATCCACATTGTTT
TAAAAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTTGTTTCAAACACAAA
TGCAGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTAGTGTGCAGTTCTAG
TTTGCATTCCTGATATGATTTAAAACATGTAATATAAAGATGTTAAAAAAAAAAACCAAAACTGTGCAGAGTCTAGAAGTTGTTTGTCAT
CTTCAGCTTGTGCACAATTCTGTTTTAGGTTAAAAAAAGGCATTGTTTGAGCTGTCCCATCTCCACTGTTATCCCTTTGGGGTTTTTTAA
TATAAATTATTAGTTTACATCATTTTTGTATCTACATCTTTTTTCACAAATTTGTCTTGCCTTATTAAAGTTCTGTAAAATATACTTAAA
TGGAAAAAATGATGTTCATTTAGATTGAAAACTTTTCTCAGATGGATTGATAATTGCATTCATCTTGTGTTTTATATGAGAAGGTGCCTC
AAGAATTTCCTGTTGGATTTGTTTAAAAGGATTTTTATCTTTCGTGATAAACTTTGCTGTGTACCAGGAACTATAAAAACAAAAACTTGT
TACTAAAGAAAATATCTGAAATGTGATAAGTTCTTATGCCATGTTAATTTCATGTGTCAACTTCAACATTTACATGTATTATTTCATTAT
GTAAAATGTTTTAGCAATTTAATATTTTGCACAGTTAGCAAACTTTGTATGTCATTTCCTTCAAGGCATCATGCAGAGTTGACATGAGAT
TTATAAGGTTTTAAGTTGTTTGCATGTGAAAATCAAATACATACTTTGGTAGTCTTTGAATACAAAGTCATCTGCTCTTGTTTTTCAAGA
ATTTTGAGACACAAAGTTGTATGTAAAGGAATATATTAATTTGCCGTTTTCTAGGTAGATTTGCTCAAAAAGAGTGAATCAACTTAATAT
GTACAAATGATAGCTGTGAAACTGTAGAATATCTTTGTGTCAGGCTTGGAGTTCATTGTGACCTCCAAATTTTGCCTGAAGGACCAGCTG
GGCAAAGCATCTTTTAAATGTTCAGAGGCCAAAAGATAAACAAAAAAAAAACCTTAAAATCCTACCTCTTTAAACAGCCTTCAGATAAGA
GAATCCTCAGTGCAATCATTATTTTGATTCGTTTGGTACCTGTTTTCCTGGAGTTCCCGATTTTATTATTTTGGGGTGGCTCCAAGCATT
AAGAGGTTTAATCTTTGATGGCATTGTTCTAGTTTTGAAATTTCTAGTATATTTCAGAGTCTCTTAGAAGACTTGTGTGGGAAGTTTCAC
TTTGTTTTCAGTGAAGATCACAAACCTCCTTCTTCCTTTACTCAAGAGGAAAGGTCCCAGTATACATATTTGAATGGTTGATGGTTTTCA
AGACCTTCAGGGAGCTCCCTGCATTTTACCTAGAAACAGAAAAGGCCCGCAAAATCTTAAGTTTCCTGGCCTGCATTTCCCGGGTAGGGG
CAAATGACTCCAAGCTGGTCTCTAAGCCAATACCCTTATAAACCAGAGCCCAGGAAAGACAGCTCGAGTGTATAATTCTCTGGAGCTCAA
TTCTATGCAGTTGTGCTGATATTTCATTAAGTCACTGTGTATTTTTAAGTGTTGATACATTAAAAGTCGCTTTATGGAAGATGAGTAAAT
TTTTTAAATACTTGGAAATTTTATTTCCTTGTTAACTTCTACAGATCAGGGCATGCAACCAAAAGCAGCTTAAATGAAATATTTTAAAAT
AAAATATCAGGAAGCTATTTTTAGATTTCTTCTGGCTTATGTTTCTACTTTAGGACCCTCATTGTTCTCTTATTAAAAAAAATTATTTCC
TGTGCATCTCATGGACTGCAGGGTAAATTATTTGGGCATAAATAATTTAAATAGTTTTCTTTCATTTTGACTATCTCCAGTAATAACAGT
TTTTATTATCCAGCATATTGGCTTATTGCACAAATCTTAAAATGTACATTGACTACTTTCTGAGAAGAAAGTGGTATCAGTACTCATGAT
GAAAAGGTTACTACTGAACAAATTCACATTTCAGGAACACCTCTATCTTTGGTTTAAATCTTACTCTTAGTTTTTCCGTCTAAAAATCAT
ACTGGTATTAGTATCAGGTAAGGAAATTAAAGTTTTTAAAATGGTTTCATTCTCTGCAATATGCAAAATTTAGATTTTACTTTCTGGTAC
TGTAAAGAACCTGAAGTGATTTACACTTAATGGGTGATTAATCCAGTATTCTTTACCCTGAATGTTTGGATATTAAAGTTCCTTTATGTT
TTCTATAACCTGTGGGATCTTCTTGCAGTGATTATTGTGTGTGAGATTTTTTTTCTTTTTGGTCTATCCATATTGTTATATTCACTCAGG
TATTTTTTTTTTAATCTTATTCCAGAATCAGTGGTTTATATTGGGTTACTGTTTAACACCAAATGGAATTGGCATTCTGCAGATTTAATT
AATTATGAAACCAGGGTCTCATTTTCCTTGCTGATACTTGTTGAAAATGAGATTCACATTCTAGTCTTTATTTTCCTCCTGTTTTGTCCC
TGTGCTTGTACATCTTCCTTTTATTTGTGTGTTATAGTTCTATTCCATTTGAGAAGGCAGTTGGTAAGAACTAGATTGCATGTACAAAGA
CAGGTTTACTAAGTGCTGTACAGTGGTCCTGAGGTTACAGTTGAATTAGAAAAACGAAATGTACTTACAGGAAATAAGAAAGCAAACCTT
TCAAATGAGAGTGATGATTTCTTTAAAAAAAATCAGTTTTTTTCTCTCAAATAATGTTCTTTATTTCACGAAATCGTCAATCTTAAGCAT
GAGCAGGGATAAACAACTCCTAGAAGGAACTCAATTCATTCTTCCTGGATTTTCTCTGTTGTTAAATCACAAAAATGATAGTCCCCAATC
GTTTCTTTATAGGAGGTTATTACATTTCATTACAGTCACTGCATTTTGACTGTTGTGTTTAGAATTTGAATGTACATCCAAAATGATGAG

>50180_50180_3_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000433529_length(amino acids)=335AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR
QTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQIGQ

--------------------------------------------------------------
>50180_50180_4_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000445587_length(transcript)=1225nt_BP=406nt
AGGATCCCGCCCCAACCAGCGCCAGGCCACGCCCCGGCGTGTGACGCAAGCACGCTCCGTGCGCGCCGTCGCGTCGCGGCGCTCACTGGG
GGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGCGAGTACTTCAGCGT
TGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCCAAAATGCTGGCTTT
AAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTGGAAATAATTAATGA
CCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGTGGCCAGTGGCTTGG
TGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAACAGCTATCATATGA
TGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAACTAATGCGTCAGAC
TTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGTCAGACACAGTCTTCTGCACCATG
GATGGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTATCGAGTGGCAGGGTA
TGAAACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGTTTACTTAAAGATTT
ATCAAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTATCATCCACATTGTTT
TAAAAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTTGTTTCAAACACAAA
TGCAGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTAGTGTGCAGTTCTAG

>50180_50180_4_LSM12-TIA1_LSM12_chr17_42141168_ENST00000293406_TIA1_chr2_70444126_ENST00000445587_length(amino acids)=245AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR

--------------------------------------------------------------
>50180_50180_5_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000282574_length(transcript)=3529nt_BP=330nt
CGGCGCTCACTGGGGGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGC
GAGTACTTCAGCGTTGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCC
AAAATGCTGGCTTTAAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTG
GAAATAATTAATGACCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGT
GGCCAGTGGCTTGGTGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAA
CAGCTATCATATGATGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAA
CTAATGCGTCAGACTTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGGTTCAATTCC
CATGAAAGTGCAGCACATGCAATTGTTTCTGTTAATGGTACTACCATTGAAGGTCATGTTGTGAAATGCTATTGGGGCAAAGAAACTCTT
GATATGATAAATCCCGTGCAACAGAATCAAATTGGATATCCCCAACCTTATGGCCAGTGGGGCCAGTGGTATGGAAATGCACAACAAATT
GGCCAGTATATGCCTAATGGTTGGCAAGTTCCTGCATATGGAATGTATGGCCAGGCATGGAACCAGCAAGGATTTAATCAGACACAGTCT
TCTGCACCATGGATGGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTATCGA
GTGGCAGGGTATGAAACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGTTTA
CTTAAAGATTTATCAAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTATCAT
CCACATTGTTTTAAAAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTTGTT
TCAAACACAAATGCAGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTAGTG
TGCAGTTCTAGTTTGCATTCCTGATATGATTTAAAACATGTAATATAAAGATGTTAAAAAAAAAAACCAAAACTGTGCAGAGTCTAGAAG
TTGTTTGTCATCTTCAGCTTGTGCACAATTCTGTTTTAGGTTAAAAAAAGGCATTGTTTGAGCTGTCCCATCTCCACTGTTATCCCTTTG
GGGTTTTTTAATATAAATTATTAGTTTACATCATTTTTGTATCTACATCTTTTTTCACAAATTTGTCTTGCCTTATTAAAGTTCTGTAAA
ATATACTTAAATGGAAAAAATGATGTTCATTTAGATTGAAAACTTTTCTCAGATGGATTGATAATTGCATTCATCTTGTGTTTTATATGA
GAAGGTGCCTCAAGAATTTCCTGTTGGATTTGTTTAAAAGGATTTTTATCTTTCGTGATAAACTTTGCTGTGTACCAGGAACTATAAAAA
CAAAAACTTGTTACTAAAGAAAATATCTGAAATGTGATAAGTTCTTATGCCATGTTAATTTCATGTGTCAACTTCAACATTTACATGTAT
TATTTCATTATGTAAAATGTTTTAGCAATTTAATATTTTGCACAGTTAGCAAACTTTGTATGTCATTTCCTTCAAGGCATCATGCAGAGT
TGACATGAGATTTATAAGGTTTTAAGTTGTTTGCATGTGAAAATCAAATACATACTTTGGTAGTCTTTGAATACAAAGTCATCTGCTCTT
GTTTTTCAAGAATTTTGAGACACAAAGTTGTATGTAAAGGAATATATTAATTTGCCGTTTTCTAGGTAGATTTGCTCAAAAAGAGTGAAT
CAACTTAATATGTACAAATGATAGCTGTGAAACTGTAGAATATCTTTGTGTCAGGCTTGGAGTTCATTGTGACCTCCAAATTTTGCCTGA
AGGACCAGCTGGGCAAAGCATCTTTTAAATGTTCAGAGGCCAAAAGATAAACAAAAAAAAAACCTTAAAATCCTACCTCTTTAAACAGCC
TTCAGATAAGAGAATCCTCAGTGCAATCATTATTTTGATTCGTTTGGTACCTGTTTTCCTGGAGTTCCCGATTTTATTATTTTGGGGTGG
CTCCAAGCATTAAGAGGTTTAATCTTTGATGGCATTGTTCTAGTTTTGAAATTTCTAGTATATTTCAGAGTCTCTTAGAAGACTTGTGTG
GGAAGTTTCACTTTGTTTTCAGTGAAGATCACAAACCTCCTTCTTCCTTTACTCAAGAGGAAAGGTCCCAGTATACATATTTGAATGGTT
GATGGTTTTCAAGACCTTCAGGGAGCTCCCTGCATTTTACCTAGAAACAGAAAAGGCCCGCAAAATCTTAAGTTTCCTGGCCTGCATTTC
CCGGGTAGGGGCAAATGACTCCAAGCTGGTCTCTAAGCCAATACCCTTATAAACCAGAGCCCAGGAAAGACAGCTCGAGTGTATAATTCT
CTGGAGCTCAATTCTATGCAGTTGTGCTGATATTTCATTAAGTCACTGTGTATTTTTAAGTGTTGATACATTAAAAGTCGCTTTATGGAA
GATGAGTAAATTTTTTAAATACTTGGAAATTTTATTTCCTTGTTAACTTCTACAGATCAGGGCATGCAACCAAAAGCAGCTTAAATGAAA
TATTTTAAAATAAAATATCAGGAAGCTATTTTTAGATTTCTTCTGGCTTATGTTTCTACTTTAGGACCCTCATTGTTCTCTTATTAAAAA
AAATTATTTCCTGTGCATCTCATGGACTGCAGGGTAAATTATTTGGGCATAAATAATTTAAATAGTTTTCTTTCATTTTGACTATCTCCA
GTAATAACAGTTTTTATTATCCAGCATATTGGCTTATTGCACAAATCTTAAAATGTACATTGACTACTTTCTGAGAAGAAAGTGGTATCA
GTACTCATGATGAAAAGGTTACTACTGAACAAATTCACATTTCAGGAACACCTCTATCTTTGGTTTAAATCTTACTCTTAGTTTTTCCGT
CTAAAAATCATACTGGTATTAGTATCAGGTAAGGAAATTAAAGTTTTTAAAATGGTTTCATTCTCTGCAATATGCAAAATTTAGATTTTA
CTTTCTGGTACTGTAAAGAACCTGAAGTGATTTACACTTAATGGGTGATTAATCCAGTATTCTTTACCCTGAATGTTTGGATATTAAAGT

>50180_50180_5_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000282574_length(amino acids)=334AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR
QTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQNQIGYPQPYGQWGQWYGNAQQIGQY

--------------------------------------------------------------
>50180_50180_6_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000415783_length(transcript)=4292nt_BP=330nt
CGGCGCTCACTGGGGGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGC
GAGTACTTCAGCGTTGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCC
AAAATGCTGGCTTTAAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTG
GAAATAATTAATGACCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGT
GGCCAGTGGCTTGGTGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAA
CAGCTATCATATGATGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAA
CTAATGCGTCAGACTTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGGTTCAATTCC
CATGAAAGTGCAGCACATGCAATTGTTTCTGTTAATGGTACTACCATTGAAGGTCATGTTGTGAAATGCTATTGGGGCAAAGAAACTCTT
GATATGATAAATCCCGTGCAACAGCAGAATCAAATTGGATATCCCCAACCTTATGGCCAGTGGGGCCAGTGGTATGGAAATGCACAACAA
ATTGGCCAGTATATGCCTAATGGTTGGCAAGTTCCTGCATATGGAATGTATGGCCAGGCATGGAACCAGCAAGGATTTAATCAGACACAG
TCTTCTGCACCATGGATGGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTAT
CGAGTGGCAGGGTATGAAACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGT
TTACTTAAAGATTTATCAAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTAT
CATCCACATTGTTTTAAAAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTT
GTTTCAAACACAAATGCAGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTA
GTGTGCAGTTCTAGTTTGCATTCCTGATATGATTTAAAACATGTAATATAAAGATGTTAAAAAAAAAAACCAAAACTGTGCAGAGTCTAG
AAGTTGTTTGTCATCTTCAGCTTGTGCACAATTCTGTTTTAGGTTAAAAAAAGGCATTGTTTGAGCTGTCCCATCTCCACTGTTATCCCT
TTGGGGTTTTTTAATATAAATTATTAGTTTACATCATTTTTGTATCTACATCTTTTTTCACAAATTTGTCTTGCCTTATTAAAGTTCTGT
AAAATATACTTAAATGGAAAAAATGATGTTCATTTAGATTGAAAACTTTTCTCAGATGGATTGATAATTGCATTCATCTTGTGTTTTATA
TGAGAAGGTGCCTCAAGAATTTCCTGTTGGATTTGTTTAAAAGGATTTTTATCTTTCGTGATAAACTTTGCTGTGTACCAGGAACTATAA
AAACAAAAACTTGTTACTAAAGAAAATATCTGAAATGTGATAAGTTCTTATGCCATGTTAATTTCATGTGTCAACTTCAACATTTACATG
TATTATTTCATTATGTAAAATGTTTTAGCAATTTAATATTTTGCACAGTTAGCAAACTTTGTATGTCATTTCCTTCAAGGCATCATGCAG
AGTTGACATGAGATTTATAAGGTTTTAAGTTGTTTGCATGTGAAAATCAAATACATACTTTGGTAGTCTTTGAATACAAAGTCATCTGCT
CTTGTTTTTCAAGAATTTTGAGACACAAAGTTGTATGTAAAGGAATATATTAATTTGCCGTTTTCTAGGTAGATTTGCTCAAAAAGAGTG
AATCAACTTAATATGTACAAATGATAGCTGTGAAACTGTAGAATATCTTTGTGTCAGGCTTGGAGTTCATTGTGACCTCCAAATTTTGCC
TGAAGGACCAGCTGGGCAAAGCATCTTTTAAATGTTCAGAGGCCAAAAGATAAACAAAAAAAAAACCTTAAAATCCTACCTCTTTAAACA
GCCTTCAGATAAGAGAATCCTCAGTGCAATCATTATTTTGATTCGTTTGGTACCTGTTTTCCTGGAGTTCCCGATTTTATTATTTTGGGG
TGGCTCCAAGCATTAAGAGGTTTAATCTTTGATGGCATTGTTCTAGTTTTGAAATTTCTAGTATATTTCAGAGTCTCTTAGAAGACTTGT
GTGGGAAGTTTCACTTTGTTTTCAGTGAAGATCACAAACCTCCTTCTTCCTTTACTCAAGAGGAAAGGTCCCAGTATACATATTTGAATG
GTTGATGGTTTTCAAGACCTTCAGGGAGCTCCCTGCATTTTACCTAGAAACAGAAAAGGCCCGCAAAATCTTAAGTTTCCTGGCCTGCAT
TTCCCGGGTAGGGGCAAATGACTCCAAGCTGGTCTCTAAGCCAATACCCTTATAAACCAGAGCCCAGGAAAGACAGCTCGAGTGTATAAT
TCTCTGGAGCTCAATTCTATGCAGTTGTGCTGATATTTCATTAAGTCACTGTGTATTTTTAAGTGTTGATACATTAAAAGTCGCTTTATG
GAAGATGAGTAAATTTTTTAAATACTTGGAAATTTTATTTCCTTGTTAACTTCTACAGATCAGGGCATGCAACCAAAAGCAGCTTAAATG
AAATATTTTAAAATAAAATATCAGGAAGCTATTTTTAGATTTCTTCTGGCTTATGTTTCTACTTTAGGACCCTCATTGTTCTCTTATTAA
AAAAAATTATTTCCTGTGCATCTCATGGACTGCAGGGTAAATTATTTGGGCATAAATAATTTAAATAGTTTTCTTTCATTTTGACTATCT
CCAGTAATAACAGTTTTTATTATCCAGCATATTGGCTTATTGCACAAATCTTAAAATGTACATTGACTACTTTCTGAGAAGAAAGTGGTA
TCAGTACTCATGATGAAAAGGTTACTACTGAACAAATTCACATTTCAGGAACACCTCTATCTTTGGTTTAAATCTTACTCTTAGTTTTTC
CGTCTAAAAATCATACTGGTATTAGTATCAGGTAAGGAAATTAAAGTTTTTAAAATGGTTTCATTCTCTGCAATATGCAAAATTTAGATT
TTACTTTCTGGTACTGTAAAGAACCTGAAGTGATTTACACTTAATGGGTGATTAATCCAGTATTCTTTACCCTGAATGTTTGGATATTAA
AGTTCCTTTATGTTTTCTATAACCTGTGGGATCTTCTTGCAGTGATTATTGTGTGTGAGATTTTTTTTCTTTTTGGTCTATCCATATTGT
TATATTCACTCAGGTATTTTTTTTTTAATCTTATTCCAGAATCAGTGGTTTATATTGGGTTACTGTTTAACACCAAATGGAATTGGCATT
CTGCAGATTTAATTAATTATGAAACCAGGGTCTCATTTTCCTTGCTGATACTTGTTGAAAATGAGATTCACATTCTAGTCTTTATTTTCC
TCCTGTTTTGTCCCTGTGCTTGTACATCTTCCTTTTATTTGTGTGTTATAGTTCTATTCCATTTGAGAAGGCAGTTGGTAAGAACTAGAT
TGCATGTACAAAGACAGGTTTACTAAGTGCTGTACAGTGGTCCTGAGGTTACAGTTGAATTAGAAAAACGAAATGTACTTACAGGAAATA
AGAAAGCAAACCTTTCAAATGAGAGTGATGATTTCTTTAAAAAAAATCAGTTTTTTTCTCTCAAATAATGTTCTTTATTTCACGAAATCG
TCAATCTTAAGCATGAGCAGGGATAAACAACTCCTAGAAGGAACTCAATTCATTCTTCCTGGATTTTCTCTGTTGTTAAATCACAAAAAT
GATAGTCCCCAATCGTTTCTTTATAGGAGGTTATTACATTTCATTACAGTCACTGCATTTTGACTGTTGTGTTTAGAATTTGAATGTACA

>50180_50180_6_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000415783_length(amino acids)=335AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR
QTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQIGQ

--------------------------------------------------------------
>50180_50180_7_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000433529_length(transcript)=4292nt_BP=330nt
CGGCGCTCACTGGGGGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGC
GAGTACTTCAGCGTTGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCC
AAAATGCTGGCTTTAAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTG
GAAATAATTAATGACCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGT
GGCCAGTGGCTTGGTGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAA
CAGCTATCATATGATGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAA
CTAATGCGTCAGACTTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGGTTCAATTCC
CATGAAAGTGCAGCACATGCAATTGTTTCTGTTAATGGTACTACCATTGAAGGTCATGTTGTGAAATGCTATTGGGGCAAAGAAACTCTT
GATATGATAAATCCCGTGCAACAGCAGAATCAAATTGGATATCCCCAACCTTATGGCCAGTGGGGCCAGTGGTATGGAAATGCACAACAA
ATTGGCCAGTATATGCCTAATGGTTGGCAAGTTCCTGCATATGGAATGTATGGCCAGGCATGGAACCAGCAAGGATTTAATCAGACACAG
TCTTCTGCACCATGGATGGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTAT
CGAGTGGCAGGGTATGAAACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGT
TTACTTAAAGATTTATCAAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTAT
CATCCACATTGTTTTAAAAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTT
GTTTCAAACACAAATGCAGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTA
GTGTGCAGTTCTAGTTTGCATTCCTGATATGATTTAAAACATGTAATATAAAGATGTTAAAAAAAAAAACCAAAACTGTGCAGAGTCTAG
AAGTTGTTTGTCATCTTCAGCTTGTGCACAATTCTGTTTTAGGTTAAAAAAAGGCATTGTTTGAGCTGTCCCATCTCCACTGTTATCCCT
TTGGGGTTTTTTAATATAAATTATTAGTTTACATCATTTTTGTATCTACATCTTTTTTCACAAATTTGTCTTGCCTTATTAAAGTTCTGT
AAAATATACTTAAATGGAAAAAATGATGTTCATTTAGATTGAAAACTTTTCTCAGATGGATTGATAATTGCATTCATCTTGTGTTTTATA
TGAGAAGGTGCCTCAAGAATTTCCTGTTGGATTTGTTTAAAAGGATTTTTATCTTTCGTGATAAACTTTGCTGTGTACCAGGAACTATAA
AAACAAAAACTTGTTACTAAAGAAAATATCTGAAATGTGATAAGTTCTTATGCCATGTTAATTTCATGTGTCAACTTCAACATTTACATG
TATTATTTCATTATGTAAAATGTTTTAGCAATTTAATATTTTGCACAGTTAGCAAACTTTGTATGTCATTTCCTTCAAGGCATCATGCAG
AGTTGACATGAGATTTATAAGGTTTTAAGTTGTTTGCATGTGAAAATCAAATACATACTTTGGTAGTCTTTGAATACAAAGTCATCTGCT
CTTGTTTTTCAAGAATTTTGAGACACAAAGTTGTATGTAAAGGAATATATTAATTTGCCGTTTTCTAGGTAGATTTGCTCAAAAAGAGTG
AATCAACTTAATATGTACAAATGATAGCTGTGAAACTGTAGAATATCTTTGTGTCAGGCTTGGAGTTCATTGTGACCTCCAAATTTTGCC
TGAAGGACCAGCTGGGCAAAGCATCTTTTAAATGTTCAGAGGCCAAAAGATAAACAAAAAAAAAACCTTAAAATCCTACCTCTTTAAACA
GCCTTCAGATAAGAGAATCCTCAGTGCAATCATTATTTTGATTCGTTTGGTACCTGTTTTCCTGGAGTTCCCGATTTTATTATTTTGGGG
TGGCTCCAAGCATTAAGAGGTTTAATCTTTGATGGCATTGTTCTAGTTTTGAAATTTCTAGTATATTTCAGAGTCTCTTAGAAGACTTGT
GTGGGAAGTTTCACTTTGTTTTCAGTGAAGATCACAAACCTCCTTCTTCCTTTACTCAAGAGGAAAGGTCCCAGTATACATATTTGAATG
GTTGATGGTTTTCAAGACCTTCAGGGAGCTCCCTGCATTTTACCTAGAAACAGAAAAGGCCCGCAAAATCTTAAGTTTCCTGGCCTGCAT
TTCCCGGGTAGGGGCAAATGACTCCAAGCTGGTCTCTAAGCCAATACCCTTATAAACCAGAGCCCAGGAAAGACAGCTCGAGTGTATAAT
TCTCTGGAGCTCAATTCTATGCAGTTGTGCTGATATTTCATTAAGTCACTGTGTATTTTTAAGTGTTGATACATTAAAAGTCGCTTTATG
GAAGATGAGTAAATTTTTTAAATACTTGGAAATTTTATTTCCTTGTTAACTTCTACAGATCAGGGCATGCAACCAAAAGCAGCTTAAATG
AAATATTTTAAAATAAAATATCAGGAAGCTATTTTTAGATTTCTTCTGGCTTATGTTTCTACTTTAGGACCCTCATTGTTCTCTTATTAA
AAAAAATTATTTCCTGTGCATCTCATGGACTGCAGGGTAAATTATTTGGGCATAAATAATTTAAATAGTTTTCTTTCATTTTGACTATCT
CCAGTAATAACAGTTTTTATTATCCAGCATATTGGCTTATTGCACAAATCTTAAAATGTACATTGACTACTTTCTGAGAAGAAAGTGGTA
TCAGTACTCATGATGAAAAGGTTACTACTGAACAAATTCACATTTCAGGAACACCTCTATCTTTGGTTTAAATCTTACTCTTAGTTTTTC
CGTCTAAAAATCATACTGGTATTAGTATCAGGTAAGGAAATTAAAGTTTTTAAAATGGTTTCATTCTCTGCAATATGCAAAATTTAGATT
TTACTTTCTGGTACTGTAAAGAACCTGAAGTGATTTACACTTAATGGGTGATTAATCCAGTATTCTTTACCCTGAATGTTTGGATATTAA
AGTTCCTTTATGTTTTCTATAACCTGTGGGATCTTCTTGCAGTGATTATTGTGTGTGAGATTTTTTTTCTTTTTGGTCTATCCATATTGT
TATATTCACTCAGGTATTTTTTTTTTAATCTTATTCCAGAATCAGTGGTTTATATTGGGTTACTGTTTAACACCAAATGGAATTGGCATT
CTGCAGATTTAATTAATTATGAAACCAGGGTCTCATTTTCCTTGCTGATACTTGTTGAAAATGAGATTCACATTCTAGTCTTTATTTTCC
TCCTGTTTTGTCCCTGTGCTTGTACATCTTCCTTTTATTTGTGTGTTATAGTTCTATTCCATTTGAGAAGGCAGTTGGTAAGAACTAGAT
TGCATGTACAAAGACAGGTTTACTAAGTGCTGTACAGTGGTCCTGAGGTTACAGTTGAATTAGAAAAACGAAATGTACTTACAGGAAATA
AGAAAGCAAACCTTTCAAATGAGAGTGATGATTTCTTTAAAAAAAATCAGTTTTTTTCTCTCAAATAATGTTCTTTATTTCACGAAATCG
TCAATCTTAAGCATGAGCAGGGATAAACAACTCCTAGAAGGAACTCAATTCATTCTTCCTGGATTTTCTCTGTTGTTAAATCACAAAAAT
GATAGTCCCCAATCGTTTCTTTATAGGAGGTTATTACATTTCATTACAGTCACTGCATTTTGACTGTTGTGTTTAGAATTTGAATGTACA

>50180_50180_7_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000433529_length(amino acids)=335AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR
QTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQIGQ

--------------------------------------------------------------
>50180_50180_8_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000445587_length(transcript)=1149nt_BP=330nt
CGGCGCTCACTGGGGGCCCGGCTTTCGCCCGCTGCTGCCGCCGCCGCCGCCGGCCGCGGCTGCACTCCCAAGATGGCGGCTCCTCCGGGC
GAGTACTTCAGCGTTGGGAGCCAGGTGTCGTGCCGGACGTGCCAGGAGCAGCGGCTGCAGGGCGAGGTGGTAGCCTTTGACTACCAATCC
AAAATGCTGGCTTTAAAATGTCCCTCTTCCAGTGGAAAGCCCAACCATGCAGACATCTTGCTCATAAACTTACAGTATGTTTCAGAAGTG
GAAATAATTAATGACCGAACAGAAACCCCTCCTCCCCTAGCTTCACTCAATGTTAGTAAGGATGCTGAAAACGCCATTCAACAGATGGGT
GGCCAGTGGCTTGGTGGAAGACAAATCAGAACTAACTGGGCAACCCGAAAGCCTCCCGCTCCAAAGAGTACATATGAGTCAAATACCAAA
CAGCTATCATATGATGAGGTTGTAAATCAGTCTAGTCCAAGCAACTGTACTGTATACTGTGGAGGTGTTACTTCTGGGCTAACAGAACAA
CTAATGCGTCAGACTTTTTCACCATTTGGACAAATAATGGAAATTCGAGTCTTTCCAGATAAAGGATATTCATTTGTTCGTCAGACACAG
TCTTCTGCACCATGGATGGGACCAAATTATGGAGTGCAACCGCCTCAAGGGCAAAATGGCAGCATGTTGCCCAATCAGCCTTCTGGGTAT
CGAGTGGCAGGGTATGAAACCCAGTGAATAAGGACTCCAGAATCTAAAGCCAGTGGCTTGAGGCTACAGGGAGTGTAGTAAAGCCGTTGT
TTACTTAAAGATTTATCAAATCAGTCAGTGCAAATGTCAGATACAATGTATTTATTTAAAAGATTCATTTTTAATCATGAAATTACTTAT
CATCCACATTGTTTTAAAAAGAAACAAGATGCTGGATGTCTGCCAATTTTTGCCTTCATTACCTTTTTTGATAAAGTTTCTCAGATCCTT
GTTTCAAACACAAATGCAGGGATTGCTGCCACTTTTTAACTATTAAGAGGCAGAAAATTGCACAATATTGAACTTTTTTCCACTGAAGTA

>50180_50180_8_LSM12-TIA1_LSM12_chr17_42141168_ENST00000585388_TIA1_chr2_70444126_ENST00000445587_length(amino acids)=245AA_BP=107
MGARLSPAAAAAAAGRGCTPKMAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEII
NDRTETPPPLASLNVSKDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LSM12-TIA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LSM12-TIA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LSM12-TIA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source