FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LSM14A-LYN (FusionGDB2 ID:50191)

Fusion Gene Summary for LSM14A-LYN

check button Fusion gene summary
Fusion gene informationFusion gene name: LSM14A-LYN
Fusion gene ID: 50191
HgeneTgene
Gene symbol

LSM14A

LYN

Gene ID

26065

4067

Gene nameLSM14A mRNA processing body assembly factorLYN proto-oncogene, Src family tyrosine kinase
SynonymsC19orf13|FAM61A|RAP55|RAP55AJTK8|p53Lyn|p56Lyn
Cytomap

19q13.11

8q12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein LSM14 homolog ALSM14 homolog ALSM14A, SCD6 homolog ARNA-associated protein 55RNA-associated protein 55AalphaSNBPfamily with sequence similarity 61, member AhRAP55hRAP55Aprotein SCD6 homologputative alpha-synuclein-binding proteintyrosine-protein kinase Lynlck/Yes-related novel protein tyrosine kinasev-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Modification date2020032720200327
UniProtAcc

Q8ND56

P0DP58

Ensembl transtripts involved in fusion geneENST00000433627, ENST00000540746, 
ENST00000544216, 		ENST00000420292, 
ENST00000519728, ENST00000520220, 
Fusion gene scores* DoF score18 X 10 X 10=180013 X 14 X 7=1274
# samples 2415
** MAII scorelog2(24/1800*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1274*10)=-3.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LSM14A [Title/Abstract] AND LYN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLSM14A(34706566)-LYN(56879274), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLSM14A

GO:0033962

cytoplasmic mRNA processing body assembly

16484376

TgeneLYN

GO:0006468

protein phosphorylation

11517336

TgeneLYN

GO:0006974

cellular response to DNA damage stimulus

10891478|11517336

TgeneLYN

GO:0018108

peptidyl-tyrosine phosphorylation

7682714|11782428

TgeneLYN

GO:0046777

protein autophosphorylation

7682714

TgeneLYN

GO:0051272

positive regulation of cellular component movement

16467205

TgeneLYN

GO:0070304

positive regulation of stress-activated protein kinase signaling cascade

10891478


check buttonFusion gene breakpoints across LSM14A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LYN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ALSM14Achr19

34706566

+LYNchr8

56879274

+


Top

Fusion Gene ORF analysis for LSM14A-LYN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000433627ENST00000420292LSM14Achr19

34706566

+LYNchr8

56879274

+
5CDS-3UTRENST00000540746ENST00000420292LSM14Achr19

34706566

+LYNchr8

56879274

+
5CDS-3UTRENST00000544216ENST00000420292LSM14Achr19

34706566

+LYNchr8

56879274

+
In-frameENST00000433627ENST00000519728LSM14Achr19

34706566

+LYNchr8

56879274

+
In-frameENST00000433627ENST00000520220LSM14Achr19

34706566

+LYNchr8

56879274

+
In-frameENST00000540746ENST00000519728LSM14Achr19

34706566

+LYNchr8

56879274

+
In-frameENST00000540746ENST00000520220LSM14Achr19

34706566

+LYNchr8

56879274

+
In-frameENST00000544216ENST00000519728LSM14Achr19

34706566

+LYNchr8

56879274

+
In-frameENST00000544216ENST00000520220LSM14Achr19

34706566

+LYNchr8

56879274

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540746LSM14Achr1934706566+ENST00000519728LYNchr856879274+1987776851524479
ENST00000540746LSM14Achr1934706566+ENST00000520220LYNchr856879274+2796776851524479
ENST00000544216LSM14Achr1934706566+ENST00000519728LYNchr856879274+2069858441606520
ENST00000544216LSM14Achr1934706566+ENST00000520220LYNchr856879274+2878858441606520
ENST00000433627LSM14Achr1934706566+ENST00000519728LYNchr856879274+2067856421604520
ENST00000433627LSM14Achr1934706566+ENST00000520220LYNchr856879274+2876856421604520

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540746ENST00000519728LSM14Achr1934706566+LYNchr856879274+0.0064943710.9935056
ENST00000540746ENST00000520220LSM14Achr1934706566+LYNchr856879274+0.0031600030.99684
ENST00000544216ENST00000519728LSM14Achr1934706566+LYNchr856879274+0.0049743530.9950257
ENST00000544216ENST00000520220LSM14Achr1934706566+LYNchr856879274+0.0024533570.9975466
ENST00000433627ENST00000519728LSM14Achr1934706566+LYNchr856879274+0.0049774450.99502254
ENST00000433627ENST00000520220LSM14Achr1934706566+LYNchr856879274+0.0024408150.9975592

Top

Fusion Genomic Features for LSM14A-LYN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LSM14Achr1934706566+LYNchr856879273+5.28E-141
LSM14Achr1934706566+LYNchr856879273+5.28E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LSM14A-LYN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34706566/chr8:56879274)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LSM14A

Q8ND56

LYN

P0DP58

FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}.FUNCTION: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (PubMed:28100642). Prevents plasticity in the primary visual cortex late in life (By similarity). {ECO:0000250|UniProtKB:P0DP60, ECO:0000269|PubMed:21252236, ECO:0000269|PubMed:28100642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLYNchr19:34706566chr8:56879274ENST00000520220713247_501242492.0DomainProtein kinase
TgeneLYNchr19:34706566chr8:56879274ENST00000520220713253_261242492.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLSM14Achr19:34706566chr8:56879274ENST00000433627+611284_3202601040.0DomainDFDF
HgeneLSM14Achr19:34706566chr8:56879274ENST00000544216+610284_320260464.0DomainDFDF
HgeneLSM14Achr19:34706566chr8:56879274ENST00000433627+611361_3772601040.0MotifNote=FFD box
HgeneLSM14Achr19:34706566chr8:56879274ENST00000433627+611380_4002601040.0MotifNote=TFG box
HgeneLSM14Achr19:34706566chr8:56879274ENST00000544216+610361_377260464.0MotifNote=FFD box
HgeneLSM14Achr19:34706566chr8:56879274ENST00000544216+610380_400260464.0MotifNote=TFG box
TgeneLYNchr19:34706566chr8:56879274ENST00000519728713129_226263513.0DomainSH2
TgeneLYNchr19:34706566chr8:56879274ENST00000519728713247_501263513.0DomainProtein kinase
TgeneLYNchr19:34706566chr8:56879274ENST0000051972871363_123263513.0DomainSH3
TgeneLYNchr19:34706566chr8:56879274ENST00000520220713129_226242492.0DomainSH2
TgeneLYNchr19:34706566chr8:56879274ENST0000052022071363_123242492.0DomainSH3
TgeneLYNchr19:34706566chr8:56879274ENST00000519728713253_261263513.0Nucleotide bindingATP


Top

Fusion Gene Sequence for LSM14A-LYN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50191_50191_1_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000433627_LYN_chr8_56879274_ENST00000519728_length(transcript)=2067nt_BP=856nt
CGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCACC
CCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCACC
GTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACATT
ATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTCAG
TCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTCCG
AGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTACC
TTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGTCGCTCAAGCCCTCAG
TTAGACCCTTTGAGAAAAAGCCCAACCATGGAACAAGCAGTGCAGACCGCCTCAGCCCACTTACCTGCTCCAGCAGCTGTTGGGAGAAGG
AGTCCTGTATCAACCAGGCCTTTGCCATCTGCCAGCCAAAAGGCAGGAGAGAATCAGGAGCACAGGCGAGCTGAAGTACACAAAGTTTCA
AGGCCAGAAAATGAGCAACTCAGAAATGATAACAAGAGACAAGTAGGTTACTATAACAACAGTACCAAGGTGGCTGTGAAAACCCTGAAG
CCAGGAACTATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAGCTCGTGAGGCTCTACGCTGTG
GTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTACATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGAAGGTGGCAAA
GTGCTGCTTCCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACCTG
CGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACACA
GCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGTCC
TTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCAG
GGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGACCA
ACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGACCC
GTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCTGC
CGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTCCA
CTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACATCT
ATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCAAT

>50191_50191_1_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000433627_LYN_chr8_56879274_ENST00000519728_length(amino acids)=520AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA
EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKI

--------------------------------------------------------------
>50191_50191_2_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000433627_LYN_chr8_56879274_ENST00000520220_length(transcript)=2876nt_BP=856nt
CGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCACC
CCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCACC
GTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACATT
ATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTCAG
TCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTCCG
AGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTACC
TTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGTCGCTCAAGCCCTCAG
TTAGACCCTTTGAGAAAAAGCCCAACCATGGAACAAGCAGTGCAGACCGCCTCAGCCCACTTACCTGCTCCAGCAGCTGTTGGGAGAAGG
AGTCCTGTATCAACCAGGCCTTTGCCATCTGCCAGCCAAAAGGCAGGAGAGAATCAGGAGCACAGGCGAGCTGAAGTACACAAAGTTTCA
AGGCCAGAAAATGAGCAACTCAGAAATGATAACAAGAGACAAGTAGGTTACTATAACAACAGTACCAAGGTGGCTGTGAAAACCCTGAAG
CCAGGAACTATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAGCTCGTGAGGCTCTACGCTGTG
GTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTACATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGAAGGTGGCAAA
GTGCTGCTTCCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACCTG
CGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACACA
GCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGTCC
TTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCAG
GGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGACCA
ACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGACCC
GTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCTGC
CGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTCCA
CTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACATCT
ATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCAAT
AATTGCAGAACTAAACTCATTTATAAAGCTAAAATAACCGGATATATACATAGCATGACATTTCTTTGTGCTTTGGCTTACTTGTTTAAA
AAAAAAAAAAAACTAATCCAACCTGTTAGATTTTGCAGGTGAAGTCAGCAGCTTAAAAATGTCTTTCCCAGATTTCAATGATTTTTTTCC
CCCTACCTCCCAAAATCTGAGACTGTTAAAACATTTTTCTTCTATGAACACTGCTCAGACCTGCTAGACATGCCATAGGAGTGGCGTGCA
CATCTCTCTCTCTTCCAGCAGGAGGAGCCCGTGAGCACGCACAGCTGCCCTGTCTGCTCACCCGAAGGCACCGGGCTCACCTGGACCTCC
CAGGAAAGGGAGAAGAGCCTCAGAAACTGCTCTGTGTTTAGAAGGAATATTTTTAAGAGTCCAGCTTTTTCATTTCCACAATTTCCTATA
TCCAGATTTGTTTTGACAATGTAGTTTGGAAGAACTAAGATTCTAATCTCTGAAGAACCTTATAGGGCCTTCTAAAACATAAGAGTTTCC
TTTGTTGCTTCAAATATTTGAACATTATGTTAAAGATCAAGTATTAATTTTAGTTGTACTCTAGAAAGCTAAAGTGCCACATTCGGGGCT
ATTTTTATGATTCAGCAATCTTTTCTAAATTGTGTAGCATGTGTATGAGACTATTTATACCCAAGGATATGAAGGAACATAAGTGACTAC
AAGGCTCTAATAAGCCACGGTGGCAGGAGGTTCAAGCGGTTCTGTTCACTAAATTTTTCTCCTGTAAGCTTTGAATGGAAACTTCTGTAT

>50191_50191_2_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000433627_LYN_chr8_56879274_ENST00000520220_length(amino acids)=520AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA
EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKI

--------------------------------------------------------------
>50191_50191_3_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000540746_LYN_chr8_56879274_ENST00000519728_length(transcript)=1987nt_BP=776nt
ATGTTGGGTCTGAAGCGGCTGCTGTAGGCGCCGACGGAGCGAGCGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCG
AGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCACCCCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCG
CTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCACCGTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGAC
AGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACATTATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACC
AAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTCAGTCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTA
TGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTCCGAGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGGTCGCTC
AAGCCCTCAGTTAGACCCTTTGAGAAAAAGCCCAACCATGGAACAAGCAGTGCAGACCGCCTCAGCCCACTTACCTGCTCCAGCAGCTGT
TGGGAGAAGGAGTCCTGTATCAACCAGGCCTTTGCCATCTGCCAGCCAAAAGGCAGGAGAGAATCAGGAGCACAGGCGAGCTGAAGTACA
CAAAGTTTCAAGGCCAGAAAATGAGCAACTCAGAAATGATAACAAGAGACAAGTAGGTTACTATAACAACAGTACCAAGGTGGCTGTGAA
AACCCTGAAGCCAGGAACTATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAGCTCGTGAGGCT
CTACGCTGTGGTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTACATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGA
AGGTGGCAAAGTGCTGCTTCCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCA
CCGGGACCTGCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAA
TGAGTACACAGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGA
TGTGTGGTCCTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGC
CCTGTCCCAGGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGA
AGAGAGACCAACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCAC
AGGGAGACCCGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGG
GATCATCTGCCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGAT
GGATTCTCCACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAA
GAAAACATCTATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATG
AATCCCCAATAATTGCAGAACTAAACTCATTTATAAAGCTAAAATAACCGGATATATACATAGCATGACATTTCTTTGTGCTTTGGCTTA

>50191_50191_3_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000540746_LYN_chr8_56879274_ENST00000519728_length(amino acids)=479AA_BP=230
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV
RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE
DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK

--------------------------------------------------------------
>50191_50191_4_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000540746_LYN_chr8_56879274_ENST00000520220_length(transcript)=2796nt_BP=776nt
ATGTTGGGTCTGAAGCGGCTGCTGTAGGCGCCGACGGAGCGAGCGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCG
AGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCACCCCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCG
CTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCACCGTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGAC
AGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACATTATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACC
AAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTCAGTCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTA
TGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTCCGAGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGGTCGCTC
AAGCCCTCAGTTAGACCCTTTGAGAAAAAGCCCAACCATGGAACAAGCAGTGCAGACCGCCTCAGCCCACTTACCTGCTCCAGCAGCTGT
TGGGAGAAGGAGTCCTGTATCAACCAGGCCTTTGCCATCTGCCAGCCAAAAGGCAGGAGAGAATCAGGAGCACAGGCGAGCTGAAGTACA
CAAAGTTTCAAGGCCAGAAAATGAGCAACTCAGAAATGATAACAAGAGACAAGTAGGTTACTATAACAACAGTACCAAGGTGGCTGTGAA
AACCCTGAAGCCAGGAACTATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAGCTCGTGAGGCT
CTACGCTGTGGTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTACATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGA
AGGTGGCAAAGTGCTGCTTCCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCA
CCGGGACCTGCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAA
TGAGTACACAGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGA
TGTGTGGTCCTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGC
CCTGTCCCAGGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGA
AGAGAGACCAACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCAC
AGGGAGACCCGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGG
GATCATCTGCCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGAT
GGATTCTCCACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAA
GAAAACATCTATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATG
AATCCCCAATAATTGCAGAACTAAACTCATTTATAAAGCTAAAATAACCGGATATATACATAGCATGACATTTCTTTGTGCTTTGGCTTA
CTTGTTTAAAAAAAAAAAAAAACTAATCCAACCTGTTAGATTTTGCAGGTGAAGTCAGCAGCTTAAAAATGTCTTTCCCAGATTTCAATG
ATTTTTTTCCCCCTACCTCCCAAAATCTGAGACTGTTAAAACATTTTTCTTCTATGAACACTGCTCAGACCTGCTAGACATGCCATAGGA
GTGGCGTGCACATCTCTCTCTCTTCCAGCAGGAGGAGCCCGTGAGCACGCACAGCTGCCCTGTCTGCTCACCCGAAGGCACCGGGCTCAC
CTGGACCTCCCAGGAAAGGGAGAAGAGCCTCAGAAACTGCTCTGTGTTTAGAAGGAATATTTTTAAGAGTCCAGCTTTTTCATTTCCACA
ATTTCCTATATCCAGATTTGTTTTGACAATGTAGTTTGGAAGAACTAAGATTCTAATCTCTGAAGAACCTTATAGGGCCTTCTAAAACAT
AAGAGTTTCCTTTGTTGCTTCAAATATTTGAACATTATGTTAAAGATCAAGTATTAATTTTAGTTGTACTCTAGAAAGCTAAAGTGCCAC
ATTCGGGGCTATTTTTATGATTCAGCAATCTTTTCTAAATTGTGTAGCATGTGTATGAGACTATTTATACCCAAGGATATGAAGGAACAT
AAGTGACTACAAGGCTCTAATAAGCCACGGTGGCAGGAGGTTCAAGCGGTTCTGTTCACTAAATTTTTCTCCTGTAAGCTTTGAATGGAA
ACTTCTGTATCACATGATGTGTTTCACTTATGCTGTTGTGTATATACCTAATATTTCTATTTTTGATTTTATTTTAATACACCTCGTCCA

>50191_50191_4_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000540746_LYN_chr8_56879274_ENST00000520220_length(amino acids)=479AA_BP=230
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV
RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE
DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK

--------------------------------------------------------------
>50191_50191_5_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000544216_LYN_chr8_56879274_ENST00000519728_length(transcript)=2069nt_BP=858nt
AGCGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCA
CCCCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCA
CCGTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACA
TTATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTC
AGTCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTC
CGAGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTA
CCTTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGTCGCTCAAGCCCTC
AGTTAGACCCTTTGAGAAAAAGCCCAACCATGGAACAAGCAGTGCAGACCGCCTCAGCCCACTTACCTGCTCCAGCAGCTGTTGGGAGAA
GGAGTCCTGTATCAACCAGGCCTTTGCCATCTGCCAGCCAAAAGGCAGGAGAGAATCAGGAGCACAGGCGAGCTGAAGTACACAAAGTTT
CAAGGCCAGAAAATGAGCAACTCAGAAATGATAACAAGAGACAAGTAGGTTACTATAACAACAGTACCAAGGTGGCTGTGAAAACCCTGA
AGCCAGGAACTATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAGCTCGTGAGGCTCTACGCTG
TGGTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTACATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGAAGGTGGCA
AAGTGCTGCTTCCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACC
TGCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACA
CAGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGT
CCTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCC
AGGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGAC
CAACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGAC
CCGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCT
GCCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTC
CACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACAT
CTATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCA

>50191_50191_5_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000544216_LYN_chr8_56879274_ENST00000519728_length(amino acids)=520AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA
EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKI

--------------------------------------------------------------
>50191_50191_6_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000544216_LYN_chr8_56879274_ENST00000520220_length(transcript)=2878nt_BP=858nt
AGCGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCA
CCCCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCA
CCGTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACA
TTATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTC
AGTCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTC
CGAGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTA
CCTTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGTCGCTCAAGCCCTC
AGTTAGACCCTTTGAGAAAAAGCCCAACCATGGAACAAGCAGTGCAGACCGCCTCAGCCCACTTACCTGCTCCAGCAGCTGTTGGGAGAA
GGAGTCCTGTATCAACCAGGCCTTTGCCATCTGCCAGCCAAAAGGCAGGAGAGAATCAGGAGCACAGGCGAGCTGAAGTACACAAAGTTT
CAAGGCCAGAAAATGAGCAACTCAGAAATGATAACAAGAGACAAGTAGGTTACTATAACAACAGTACCAAGGTGGCTGTGAAAACCCTGA
AGCCAGGAACTATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAGCTCGTGAGGCTCTACGCTG
TGGTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTACATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGAAGGTGGCA
AAGTGCTGCTTCCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAGAACTACATTCACCGGGACC
TGCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGCAAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACA
CAGCAAGGGAAGGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACTATTAAGTCTGATGTGTGGT
CCTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAAATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCC
AGGGCTACAGGATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAAGAAAAGGCAGAAGAGAGAC
CAACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTACACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAGAGCACAGGGAGAC
CCGTCCATTTGGCAGGGGTGGCTGCCTCATTTAGAGAGGAAAAGTAACCATCACTGGTTGCACTTATGATTTCATGTGCGGGGATCATCT
GCCGTGCCTGGATCCTGAAATAGAGGCTAAATTACTCAGGAAGAACACCCTCTAAATGGGAAAGTATTCTGTACTCTTAGATGGATTCTC
CACTCAGTTGCAACTTGGACTTGTCCTCAGCAGCTGGTAATCTTGCTCTGCTTGACAACATCTGAGTGCAGCCGTTTGAGAAGAAAACAT
CTATTCTCTCCAAAAATGCACCCAACTAGCTCTATGTTTACAAATGGACATAGGACTCAAAGTTTCAGAGACCATTGCAATGAATCCCCA
ATAATTGCAGAACTAAACTCATTTATAAAGCTAAAATAACCGGATATATACATAGCATGACATTTCTTTGTGCTTTGGCTTACTTGTTTA
AAAAAAAAAAAAAACTAATCCAACCTGTTAGATTTTGCAGGTGAAGTCAGCAGCTTAAAAATGTCTTTCCCAGATTTCAATGATTTTTTT
CCCCCTACCTCCCAAAATCTGAGACTGTTAAAACATTTTTCTTCTATGAACACTGCTCAGACCTGCTAGACATGCCATAGGAGTGGCGTG
CACATCTCTCTCTCTTCCAGCAGGAGGAGCCCGTGAGCACGCACAGCTGCCCTGTCTGCTCACCCGAAGGCACCGGGCTCACCTGGACCT
CCCAGGAAAGGGAGAAGAGCCTCAGAAACTGCTCTGTGTTTAGAAGGAATATTTTTAAGAGTCCAGCTTTTTCATTTCCACAATTTCCTA
TATCCAGATTTGTTTTGACAATGTAGTTTGGAAGAACTAAGATTCTAATCTCTGAAGAACCTTATAGGGCCTTCTAAAACATAAGAGTTT
CCTTTGTTGCTTCAAATATTTGAACATTATGTTAAAGATCAAGTATTAATTTTAGTTGTACTCTAGAAAGCTAAAGTGCCACATTCGGGG
CTATTTTTATGATTCAGCAATCTTTTCTAAATTGTGTAGCATGTGTATGAGACTATTTATACCCAAGGATATGAAGGAACATAAGTGACT
ACAAGGCTCTAATAAGCCACGGTGGCAGGAGGTTCAAGCGGTTCTGTTCACTAAATTTTTCTCCTGTAAGCTTTGAATGGAAACTTCTGT

>50191_50191_6_LSM14A-LYN_LSM14A_chr19_34706566_ENST00000544216_LYN_chr8_56879274_ENST00000520220_length(amino acids)=520AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA
EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LSM14A-LYN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LSM14A-LYN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LSM14A-LYN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource