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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LSM14A-UBA2 (FusionGDB2 ID:50196)

Fusion Gene Summary for LSM14A-UBA2

Fusion gene summary

Fusion gene information	Fusion gene name: LSM14A-UBA2
	Fusion gene ID: 50196
		Hgene	Tgene
	Gene symbol	LSM14A	UBA2
	Gene ID	26065	10054
	Gene name	LSM14A mRNA processing body assembly factor	ubiquitin like modifier activating enzyme 2
	Synonyms	C19orf13\|FAM61A\|RAP55\|RAP55A	ARX\|HRIHFB2115\|SAE2
	Cytomap	19q13.11	19q13.11
	Type of gene	protein-coding	protein-coding
	Description	protein LSM14 homolog ALSM14 homolog ALSM14A, SCD6 homolog ARNA-associated protein 55RNA-associated protein 55AalphaSNBPfamily with sequence similarity 61, member AhRAP55hRAP55Aprotein SCD6 homologputative alpha-synuclein-binding protein	SUMO-activating enzyme subunit 2SUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 2UBA2, ubiquitin-activating enzyme E1 homologanthracycline-associated resistance ARXubiquitin-like 1-activating enzyme E1B
	Modification date	20200327	20200313
	UniProtAcc	Q8ND56	.
	Ensembl transtripts involved in fusion gene	ENST00000433627, ENST00000544216, ENST00000540746,	ENST00000588585, ENST00000592791, ENST00000246548, ENST00000439527,
Fusion gene scores	* DoF score	18 X 10 X 10=1800	8 X 6 X 5=240
	# samples	24	8
	** MAII score	log2(24/1800*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LSM14A [Title/Abstract] AND UBA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LSM14A(34699956)-UBA2(34942886), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LSM14A	GO:0033962	cytoplasmic mRNA processing body assembly	16484376
Tgene	UBA2	GO:0016925	protein sumoylation	20164921
Tgene	UBA2	GO:0033235	positive regulation of protein sumoylation	10187858

Fusion gene breakpoints across LSM14A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-1114-01B	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+

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Fusion Gene ORF analysis for LSM14A-UBA2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000433627	ENST00000588585	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
5CDS-intron	ENST00000433627	ENST00000592791	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
5CDS-intron	ENST00000544216	ENST00000588585	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
5CDS-intron	ENST00000544216	ENST00000592791	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
In-frame	ENST00000433627	ENST00000246548	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
In-frame	ENST00000433627	ENST00000439527	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
In-frame	ENST00000544216	ENST00000246548	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
In-frame	ENST00000544216	ENST00000439527	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
intron-3CDS	ENST00000540746	ENST00000246548	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
intron-3CDS	ENST00000540746	ENST00000439527	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
intron-intron	ENST00000540746	ENST00000588585	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+
intron-intron	ENST00000540746	ENST00000592791	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000544216

LSM14A

chr19

34699956

ENST00000246548

UBA2

chr19

34942886

2394

615

1666

540

ENST00000544216

LSM14A

chr19

34699956

ENST00000439527

UBA2

chr19

34942886

2336

615

1666

540

ENST00000433627

LSM14A

chr19

34699956

ENST00000246548

UBA2

chr19

34942886

2392

613

1664

540

ENST00000433627

LSM14A

chr19

34699956

ENST00000439527

UBA2

chr19

34942886

2334

613

1664

540

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000544216	ENST00000246548	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+	0.001268011	0.99873203
ENST00000544216	ENST00000439527	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+	0.001382001	0.998618
ENST00000433627	ENST00000246548	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+	0.001266004	0.99873406
ENST00000433627	ENST00000439527	LSM14A	chr19	34699956	+	UBA2	chr19	34942886	+	0.001381521	0.9986185

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Fusion Genomic Features for LSM14A-UBA2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LSM14A	chr19	34699956	+	UBA2	chr19	34942885	+	3.39E-06	0.99999666
LSM14A	chr19	34699956	+	UBA2	chr19	34942885	+	3.39E-06	0.99999666

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LSM14A-UBA2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34699956/chr19:34942886)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LSM14A Q8ND56	.
FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269\|PubMed:16484376, ECO:0000269\|PubMed:17074753, ECO:0000269\|PubMed:26339800, ECO:0000269\|PubMed:29510985}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LSM14A

chr19:34699956

chr19:34942886

ENST00000433627

284_320

179

1040.0

Domain

DFDF

Hgene

LSM14A

chr19:34699956

chr19:34942886

ENST00000544216

284_320

179

464.0

Domain

DFDF

Hgene

LSM14A

chr19:34699956

chr19:34942886

ENST00000433627

361_377

179

1040.0

Motif

Note=FFD box

Hgene

LSM14A

chr19:34699956

chr19:34942886

ENST00000433627

380_400

179

1040.0

Motif

Note=TFG box

Hgene

LSM14A

chr19:34699956

chr19:34942886

ENST00000544216

361_377

179

464.0

Motif

Note=FFD box

Hgene

LSM14A

chr19:34699956

chr19:34942886

ENST00000544216

380_400

179

464.0

Motif

Note=TFG box

Tgene

UBA2

chr19:34699956

chr19:34942886

ENST00000246548

117_122

290

641.0

Nucleotide binding

ATP

Tgene

UBA2

chr19:34699956

chr19:34942886

ENST00000246548

24_29

290

641.0

Nucleotide binding

ATP

Tgene

UBA2

chr19:34699956

chr19:34942886

ENST00000246548

56_59

290

641.0

Nucleotide binding

ATP

Tgene

UBA2

chr19:34699956

chr19:34942886

ENST00000246548

95_96

290

641.0

Nucleotide binding

ATP

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Fusion Gene Sequence for LSM14A-UBA2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50196_50196_1_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000433627_UBA2_chr19_34942886_ENST00000246548_length(transcript)=2392nt_BP=613nt
CGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCACC
CCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCACC
GTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACATT
ATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTCAG
TCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTCCG
AGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTACC
TTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGAGAAGAAACGAATGCA
TCAGATCAACAGAATGAACCCCAGTTAGGCCTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCATC
GAGACTTTGAGAGTTCATTTAGCAGAAAAGGGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCACC
TCTGCTGCAAACCTCAGGATGCATATTTTCAGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTGCT
ATTGCTACTACTAATGCAGTAATTGCTGGGTTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAATT
TTTTTGAATAAACAACCAAACCCAAGAAAGAAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCAGC
AAGCCAGAGGTGACTGTGCGGCTGAATGTCCATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGGTA
GCACCAGATGTCCAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGTTG
TCAGAATTTGGAATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTGAA
GACCTAGGAAAGGACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCATA
ACCAATGGCAGTGATGATGGAGCTCAGCCCTCCACCTCCACAGCTCAAGAGCAAGATGACGTTCTCATAGTTGATTCAGATGAAGAAGAT
TCTTCAAATAATGCCGACGTCAGTGAAGAAGAGAGAAGCCGCAAGAGGAAATTAGATGAGAAAGAGAATCTCAGTGCAAAGAGGTCACGT
ATAGAACAGAAGGAAGAGCTTGATGATGTCATAGCATTAGATTGAACAGAAATGCCTCTAAACAGAACCCTCTTACTATTTAGTTTATCT
GGGCAGAACCAGATTGTTATGTCCTTTGTTCCAAAGGGAAAAAATTGACAGCAGTGACTTGAAAATGATTCTGCTCCCTTTGAAAGCATT
CATTTTGCTAGAACTGTTAGACACATTGCAGTATGCTGTATTGAAAGTAGGAATATAGTTTTAAAAACCCTTTGAACAAAGTGTGTGCAT
AACCAGTCATGAGATAAAACAACACAATGCATGTTGCCTTTTTAATGTAAATACCCGTAGGTATCATTAATAGTTTCAAAATATTGTGGT
TTAGTAAAGTTGATACCTGGTTATAAATATTATGCCTTTATTTTTGGCTAGAAGAAGAATTATTTTTAGCCTAGATCTAACCATTTTCAT
ACTCTTAACTGATTGAAACAGATTCAAAGAAGTATCGAGTGCTATGCATTGAAACTTGTTTTTAAATGTTAGATGGCACTATGTATATTA
ATGTAAAACAATGTTAATTTACTCAAGTTTTCAGTTTGTACCGCCTGGTATGTCTGTGTAAGAAGCCAATTTTTGTGTATTGTTACAGTT
TCAGGTTATTTATATTCGATGTTTTGTAAAACTCAAATAACGACTATACTTATGGACCAAATAAATGGCATCTGCATTCTTGTTACACAT

>50196_50196_1_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000433627_UBA2_chr19_34942886_ENST00000246548_length(amino acids)=540AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM
KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVT
VLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDA
PEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD

--------------------------------------------------------------
>50196_50196_2_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000433627_UBA2_chr19_34942886_ENST00000439527_length(transcript)=2334nt_BP=613nt
CGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCACC
CCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCACC
GTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACATT
ATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTCAG
TCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTCCG
AGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTACC
TTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGAGAAGAAACGAATGCA
TCAGATCAACAGAATGAACCCCAGTTAGGCCTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCATC
GAGACTTTGAGAGTTCATTTAGCAGAAAAGGGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCACC
TCTGCTGCAAACCTCAGGATGCATATTTTCAGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTGCT
ATTGCTACTACTAATGCAGTAATTGCTGGGTTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAATT
TTTTTGAATAAACAACCAAACCCAAGAAAGAAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCAGC
AAGCCAGAGGTGACTGTGCGGCTGAATGTCCATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGGTA
GCACCAGATGTCCAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGTTG
TCAGAATTTGGAATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTGAA
GACCTAGGAAAGGACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCATA
ACCAATGGCAGTGATGATGGAGCTCAGCCCTCCACCTCCACAGCTCAAGAGCAAGATGACGTTCTCATAGTTGATTCAGATGAAGAAGAT
TCTTCAAATAATGCCGACGTCAGTGAAGAAGAGAGAAGCCGCAAGAGGAAATTAGATGAGAAAGAGAATCTCAGTGCAAAGAGGTCACGT
ATAGAACAGAAGGAAGAGCTTGATGATGTCATAGCATTAGATTGAACAGAAATGCCTCTAAACAGAACCCTCTTACTATTTAGTTTATCT
GGGCAGAACCAGATTGTTATGTCCTTTGTTCCAAAGGGAAAAAATTGACAGCAGTGACTTGAAAATGATTCTGCTCCCTTTGAAAGCATT
CATTTTGCTAGAACTGTTAGACACATTGCAGTATGCTGTATTGAAAGTAGGAATATAGTTTTAAAAACCCTTTGAACAAAGTGTGTGCAT
AACCAGTCATGAGATAAAACAACACAATGCATGTTGCCTTTTTAATGTAAATACCCGTAGGTATCATTAATAGTTTCAAAATATTGTGGT
TTAGTAAAGTTGATACCTGGTTATAAATATTATGCCTTTATTTTTGGCTAGAAGAAGAATTATTTTTAGCCTAGATCTAACCATTTTCAT
ACTCTTAACTGATTGAAACAGATTCAAAGAAGTATCGAGTGCTATGCATTGAAACTTGTTTTTAAATGTTAGATGGCACTATGTATATTA
ATGTAAAACAATGTTAATTTACTCAAGTTTTCAGTTTGTACCGCCTGGTATGTCTGTGTAAGAAGCCAATTTTTGTGTATTGTTACAGTT

>50196_50196_2_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000433627_UBA2_chr19_34942886_ENST00000439527_length(amino acids)=540AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM
KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVT
VLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDA
PEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD

--------------------------------------------------------------
>50196_50196_3_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000544216_UBA2_chr19_34942886_ENST00000246548_length(transcript)=2394nt_BP=615nt
AGCGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCA
CCCCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCA
CCGTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACA
TTATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTC
AGTCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTC
CGAGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTA
CCTTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGAGAAGAAACGAATG
CATCAGATCAACAGAATGAACCCCAGTTAGGCCTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCA
TCGAGACTTTGAGAGTTCATTTAGCAGAAAAGGGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCA
CCTCTGCTGCAAACCTCAGGATGCATATTTTCAGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTG
CTATTGCTACTACTAATGCAGTAATTGCTGGGTTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAA
TTTTTTTGAATAAACAACCAAACCCAAGAAAGAAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCA
GCAAGCCAGAGGTGACTGTGCGGCTGAATGTCCATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGG
TAGCACCAGATGTCCAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGT
TGTCAGAATTTGGAATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTG
AAGACCTAGGAAAGGACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCA
TAACCAATGGCAGTGATGATGGAGCTCAGCCCTCCACCTCCACAGCTCAAGAGCAAGATGACGTTCTCATAGTTGATTCAGATGAAGAAG
ATTCTTCAAATAATGCCGACGTCAGTGAAGAAGAGAGAAGCCGCAAGAGGAAATTAGATGAGAAAGAGAATCTCAGTGCAAAGAGGTCAC
GTATAGAACAGAAGGAAGAGCTTGATGATGTCATAGCATTAGATTGAACAGAAATGCCTCTAAACAGAACCCTCTTACTATTTAGTTTAT
CTGGGCAGAACCAGATTGTTATGTCCTTTGTTCCAAAGGGAAAAAATTGACAGCAGTGACTTGAAAATGATTCTGCTCCCTTTGAAAGCA
TTCATTTTGCTAGAACTGTTAGACACATTGCAGTATGCTGTATTGAAAGTAGGAATATAGTTTTAAAAACCCTTTGAACAAAGTGTGTGC
ATAACCAGTCATGAGATAAAACAACACAATGCATGTTGCCTTTTTAATGTAAATACCCGTAGGTATCATTAATAGTTTCAAAATATTGTG
GTTTAGTAAAGTTGATACCTGGTTATAAATATTATGCCTTTATTTTTGGCTAGAAGAAGAATTATTTTTAGCCTAGATCTAACCATTTTC
ATACTCTTAACTGATTGAAACAGATTCAAAGAAGTATCGAGTGCTATGCATTGAAACTTGTTTTTAAATGTTAGATGGCACTATGTATAT
TAATGTAAAACAATGTTAATTTACTCAAGTTTTCAGTTTGTACCGCCTGGTATGTCTGTGTAAGAAGCCAATTTTTGTGTATTGTTACAG
TTTCAGGTTATTTATATTCGATGTTTTGTAAAACTCAAATAACGACTATACTTATGGACCAAATAAATGGCATCTGCATTCTTGTTACAC

>50196_50196_3_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000544216_UBA2_chr19_34942886_ENST00000246548_length(amino acids)=540AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM
KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVT
VLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDA
PEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD

--------------------------------------------------------------
>50196_50196_4_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000544216_UBA2_chr19_34942886_ENST00000439527_length(transcript)=2336nt_BP=615nt
AGCGGGCGTGCGGAGCGGGCGACAGTGGCGTGGGATCTGCCTCTCTGCGAGCAGCTGGGAGCGGCGGCGGCGGCGCCATGAGCGGGGGCA
CCCCTTACATCGGCAGCAAGATCAGCCTCATCTCCAAGGCGGAGATCCGCTACGAGGGCATCCTCTACACCATCGACACCGAAAACTCCA
CCGTAGCCCTTGCCAAAGTTCGATCCTTTGGTACAGAAGACAGACCGACAGATCGTCCAATACCACCTCGAGATGAAGTCTTTGAATACA
TTATATTCCGTGGGAGTGACATTAAAGACCTTACTGTTTGTGAGCCACCAAAACCACAGTGTTCTTTGCCTCAAGACCCAGCTATTGTTC
AGTCCTCACTAGGCTCATCGACTTCTTCATTCCAGTCCATGGGTTCTTATGGACCTTTCGGCAGGATGCCCACATACAGTCAGTTCAGTC
CGAGTTCCTTAGTTGGGCAGCAGTTTGGTGCTGTTGGTGTTGCTGGAAGCTCTTTGACATCCTTTGGAACAGAAACATCAAACAGTGGTA
CCTTACCCCAAAGTAGTGCGGTTGGTTCTGCCTTTACACAGGATACAAGATCTCTAAAAACACAGTTATCTCAAGGAGAAGAAACGAATG
CATCAGATCAACAGAATGAACCCCAGTTAGGCCTGAAAGACCAGCAGGTTCTAGATGTAAAGAGCTATGCACGTCTTTTTTCAAAGAGCA
TCGAGACTTTGAGAGTTCATTTAGCAGAAAAGGGGGATGGAGCTGAGCTCATATGGGATAAGGATGACCCATCTGCAATGGATTTTGTCA
CCTCTGCTGCAAACCTCAGGATGCATATTTTCAGTATGAATATGAAGAGTAGATTTGATATCAAATCAATGGCAGGGAACATTATTCCTG
CTATTGCTACTACTAATGCAGTAATTGCTGGGTTGATAGTATTGGAAGGATTGAAGATTTTATCAGGAAAAATAGACCAGTGCAGAACAA
TTTTTTTGAATAAACAACCAAACCCAAGAAAGAAGCTTCTTGTGCCTTGTGCACTGGATCCTCCCAACCCCAATTGTTATGTATGTGCCA
GCAAGCCAGAGGTGACTGTGCGGCTGAATGTCCATAAAGTGACTGTTCTCACCTTACAAGACAAGATAGTGAAAGAAAAATTTGCTATGG
TAGCACCAGATGTCCAAATTGAAGATGGGAAAGGAACAATCCTAATATCTTCCGAAGAGGGAGAGACGGAAGCTAATAATCACAAGAAGT
TGTCAGAATTTGGAATTAGAAATGGCAGCCGGCTTCAAGCAGATGACTTCCTCCAGGACTATACTTTATTGATCAACATCCTTCATAGTG
AAGACCTAGGAAAGGACGTTGAATTTGAAGTTGTTGGTGATGCCCCGGAAAAAGTGGGGCCCAAACAAGCTGAAGATGCTGCCAAAAGCA
TAACCAATGGCAGTGATGATGGAGCTCAGCCCTCCACCTCCACAGCTCAAGAGCAAGATGACGTTCTCATAGTTGATTCAGATGAAGAAG
ATTCTTCAAATAATGCCGACGTCAGTGAAGAAGAGAGAAGCCGCAAGAGGAAATTAGATGAGAAAGAGAATCTCAGTGCAAAGAGGTCAC
GTATAGAACAGAAGGAAGAGCTTGATGATGTCATAGCATTAGATTGAACAGAAATGCCTCTAAACAGAACCCTCTTACTATTTAGTTTAT
CTGGGCAGAACCAGATTGTTATGTCCTTTGTTCCAAAGGGAAAAAATTGACAGCAGTGACTTGAAAATGATTCTGCTCCCTTTGAAAGCA
TTCATTTTGCTAGAACTGTTAGACACATTGCAGTATGCTGTATTGAAAGTAGGAATATAGTTTTAAAAACCCTTTGAACAAAGTGTGTGC
ATAACCAGTCATGAGATAAAACAACACAATGCATGTTGCCTTTTTAATGTAAATACCCGTAGGTATCATTAATAGTTTCAAAATATTGTG
GTTTAGTAAAGTTGATACCTGGTTATAAATATTATGCCTTTATTTTTGGCTAGAAGAAGAATTATTTTTAGCCTAGATCTAACCATTTTC
ATACTCTTAACTGATTGAAACAGATTCAAAGAAGTATCGAGTGCTATGCATTGAAACTTGTTTTTAAATGTTAGATGGCACTATGTATAT
TAATGTAAAACAATGTTAATTTACTCAAGTTTTCAGTTTGTACCGCCTGGTATGTCTGTGTAAGAAGCCAATTTTTGTGTATTGTTACAG

>50196_50196_4_LSM14A-UBA2_LSM14A_chr19_34699956_ENST00000544216_UBA2_chr19_34942886_ENST00000439527_length(amino acids)=540AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGEETNASDQQNEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAANLRMHIFSMNM
KSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVT
VLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDA
PEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNNADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LSM14A-UBA2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LSM14A-UBA2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LSM14A-UBA2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source