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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LSR-NLRP2 (FusionGDB2 ID:50244)

Fusion Gene Summary for LSR-NLRP2

Fusion gene summary

Fusion gene information	Fusion gene name: LSR-NLRP2
	Fusion gene ID: 50244
		Hgene	Tgene
	Gene symbol	LSR	NLRP2
	Gene ID	51599	55655
	Gene name	lipolysis stimulated lipoprotein receptor	NLR family pyrin domain containing 2
	Synonyms	ILDR3\|LISCH7	CLR19.9\|NALP2\|NBS1\|PAN1\|PYPAF2
	Cytomap	19q13.12	19q13.42
	Type of gene	protein-coding	protein-coding
	Description	lipolysis-stimulated lipoprotein receptorLISCH proteinimmunoglobulin-like domain containing receptor 3lipolysis-stimulated remnantliver-specific bHLH-Zip transcription factor	NACHT, LRR and PYD domains-containing protein 2NACHT, leucine rich repeat and PYD containing 2PYRIN domain and NACHT domain-containing protein 1PYRIN-containing APAF1-like protein 2nucleotide-binding oligomerization domain, leucine rich repeat and pyr
	Modification date	20200313	20200320
	UniProtAcc	Q86X29	Q9NX02
	Ensembl transtripts involved in fusion gene	ENST00000597933, ENST00000347609, ENST00000354900, ENST00000360798, ENST00000361790, ENST00000427250, ENST00000602122,	ENST00000263437, ENST00000339757, ENST00000391721, ENST00000427260, ENST00000448584, ENST00000537859, ENST00000538819, ENST00000543010, ENST00000586512,
Fusion gene scores	* DoF score	10 X 6 X 6=360	6 X 7 X 3=126
	# samples	11	7
	** MAII score	log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LSR [Title/Abstract] AND NLRP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LSR(35741562)-NLRP2(55481367), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NLRP2	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	15030775
Tgene	NLRP2	GO:0050718	positive regulation of interleukin-1 beta secretion	15030775

Fusion gene breakpoints across LSR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NLRP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A891-01A	LSR	chr19	35741562	-	NLRP2	chr19	55481367	+
ChimerDB4	ESCA	TCGA-L5-A891-01A	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
ChimerDB4	ESCA	TCGA-L5-A891	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
ChimerDB4	ESCA	TCGA-L5-A891	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+

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Fusion Gene ORF analysis for LSR-NLRP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-5UTR	ENST00000597933	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-5UTR	ENST00000597933	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-5UTR	ENST00000597933	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-5UTR	ENST00000597933	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-5UTR	ENST00000597933	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-5UTR	ENST00000597933	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-5UTR	ENST00000597933	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-5UTR	ENST00000597933	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-5UTR	ENST00000597933	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
3UTR-intron	ENST00000597933	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
3UTR-intron	ENST00000597933	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000347609	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000347609	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000354900	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000354900	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000360798	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000360798	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000361790	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000361790	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000427250	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000427250	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000263437	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000339757	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000391721	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000427260	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000448584	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000537859	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000538819	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-5UTR	ENST00000602122	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-5UTR	ENST00000602122	ENST00000543010	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-intron	ENST00000347609	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-intron	ENST00000347609	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-intron	ENST00000354900	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-intron	ENST00000354900	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-intron	ENST00000360798	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-intron	ENST00000360798	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-intron	ENST00000361790	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-intron	ENST00000361790	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-intron	ENST00000427250	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-intron	ENST00000427250	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+
5CDS-intron	ENST00000602122	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481367	+
5CDS-intron	ENST00000602122	ENST00000586512	LSR	chr19	35741562	+	NLRP2	chr19	55481366	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for LSR-NLRP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
LSR	chr19	35741562	+	NLRP2	chr19	55481366	+	5.61E-14	1
LSR	chr19	35741562	+	NLRP2	chr19	55481366	+	5.61E-14	1
LSR	chr19	35741562	+	NLRP2	chr19	55481366	+	5.61E-14	1
LSR	chr19	35741562	+	NLRP2	chr19	55481366	+	5.61E-14	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LSR-NLRP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35741562/:55481367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LSR Q86X29	NLRP2 Q9NX02
FUNCTION: Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). {ECO:0000250}.	FUNCTION: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. {ECO:0000269\|PubMed:15456791}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for LSR-NLRP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LSR-NLRP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for LSR-NLRP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LSR-NLRP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source